JP5622392B2 - 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置 - Google Patents

大規模ｆｅｔアレイを用いた分析物測定のための方法および装置 Download PDF

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JP5622392B2
JP5622392B2 JP2009541416A JP2009541416A JP5622392B2 JP 5622392 B2 JP5622392 B2 JP 5622392B2 JP 2009541416 A JP2009541416 A JP 2009541416A JP 2009541416 A JP2009541416 A JP 2009541416A JP 5622392 B2 JP5622392 B2 JP 5622392B2
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array
isfet
pixel
column
sensor
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JP2010513869A5 (https=
JP2010513869A (ja
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ロスバーグ，ジョナサン，エム．
ヒンズ，ヴォルフガング
ジョンソン，キム，エル．
ビュステイロ，ジェームス
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ライフ テクノロジーズ コーポレーション
ライフ テクノロジーズ コーポレーション
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4148—Integrated circuits therefor, e.g. fabricated by CMOS processing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D30/00—Field-effect transistors [FET]
    • H10D30/60—Insulated-gate field-effect transistors [IGFET]
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D84/00—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers
    • H10D84/80—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers characterised by the integration of at least one component covered by groups H10D12/00 or H10D30/00, e.g. integration of IGFETs
    • H10D84/82—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers characterised by the integration of at least one component covered by groups H10D12/00 or H10D30/00, e.g. integration of IGFETs of only field-effect components
    • H10D84/83—Integrated devices formed in or on semiconductor substrates that comprise only semiconducting layers, e.g. on Si wafers or on GaAs-on-Si wafers characterised by the integration of at least one component covered by groups H10D12/00 or H10D30/00, e.g. integration of IGFETs of only field-effect components of only insulated-gate FETs [IGFET]
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D30/00—Field-effect transistors [FET]
    • H10D30/60—Insulated-gate field-effect transistors [IGFET]
    • H10D30/68—Floating-gate IGFETs
    • H10D30/6891—Floating-gate IGFETs characterised by the shapes, relative sizes or dispositions of the floating gate electrode
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/22—Hydrogen, per se

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
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  • Biotechnology (AREA)
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  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Computer Hardware Design (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
JP2009541416A 2006-12-14 2007-12-14 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置 Expired - Fee Related JP5622392B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US87007306P 2006-12-14 2006-12-14
US60/870,073 2006-12-14
US94874807P 2007-07-10 2007-07-10
US60/948,748 2007-07-10
US95632407P 2007-08-16 2007-08-16
US60/956,324 2007-08-16
PCT/US2007/025721 WO2008076406A2 (en) 2006-12-14 2007-12-14 Methods and apparatus for measuring analytes using large scale fet arrays

Related Child Applications (5)

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JP2012246413A Division JP5563044B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246415A Division JP5622825B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246416A Division JP5643276B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246414A Division JP5662407B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246417A Division JP5643277B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置

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JP2010513869A JP2010513869A (ja) 2010-04-30
JP2010513869A5 JP2010513869A5 (https=) 2011-04-07
JP5622392B2 true JP5622392B2 (ja) 2014-11-12

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JP2009541416A Expired - Fee Related JP5622392B2 (ja) 2006-12-14 2007-12-14 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246417A Expired - Fee Related JP5643277B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246413A Active JP5563044B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246415A Expired - Fee Related JP5622825B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246416A Expired - Fee Related JP5643276B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246414A Expired - Fee Related JP5662407B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2014245830A Expired - Fee Related JP6125485B2 (ja) 2006-12-14 2014-12-04 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2017030653A Pending JP2017127308A (ja) 2006-12-14 2017-02-22 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置

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JP2012246413A Active JP5563044B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246415A Expired - Fee Related JP5622825B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246416A Expired - Fee Related JP5643276B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2012246414A Expired - Fee Related JP5662407B2 (ja) 2006-12-14 2012-11-08 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2014245830A Expired - Fee Related JP6125485B2 (ja) 2006-12-14 2014-12-04 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置
JP2017030653A Pending JP2017127308A (ja) 2006-12-14 2017-02-22 大規模ｆｅｔアレイを用いた分析物測定のための方法および装置

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US (37) US7948015B2 (https=)
EP (10) EP2639578B1 (https=)
JP (8) JP5622392B2 (https=)
CN (1) CN101669026B (https=)
AU (1) AU2007334393A1 (https=)
CA (1) CA2672315A1 (https=)
ES (1) ES2923759T3 (https=)
GB (2) GB2457851B (https=)
WO (1) WO2008076406A2 (https=)

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