HK1125131A1 - Nuclear reprogramming factor - Google Patents

Nuclear reprogramming factor

Info

Publication number
HK1125131A1
HK1125131A1 HK09102406.5A HK09102406A HK1125131A1 HK 1125131 A1 HK1125131 A1 HK 1125131A1 HK 09102406 A HK09102406 A HK 09102406A HK 1125131 A1 HK1125131 A1 HK 1125131A1
Authority
HK
Hong Kong
Prior art keywords
cell
reprogramming factor
nuclear reprogramming
family gene
gene
Prior art date
Application number
HK09102406.5A
Other languages
English (en)
Inventor
Shinya Yamanaka
Original Assignee
Univ Kyoto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38162968&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1125131(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Kyoto filed Critical Univ Kyoto
Publication of HK1125131A1 publication Critical patent/HK1125131A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/605—Nanog
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
HK09102406.5A 2005-12-13 2009-03-12 Nuclear reprogramming factor HK1125131A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2005359537 2005-12-13
PCT/JP2006/324881 WO2007069666A1 (ja) 2005-12-13 2006-12-06 核初期化因子

Publications (1)

Publication Number Publication Date
HK1125131A1 true HK1125131A1 (en) 2009-07-31

Family

ID=38162968

Family Applications (2)

Application Number Title Priority Date Filing Date
HK09102406.5A HK1125131A1 (en) 2005-12-13 2009-03-12 Nuclear reprogramming factor
HK09103541.9A HK1125967A1 (en) 2005-12-13 2009-04-17 Nuclear reprogramming factor

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK09103541.9A HK1125967A1 (en) 2005-12-13 2009-04-17 Nuclear reprogramming factor

Country Status (18)

Country Link
US (1) US8048999B2 (ja)
EP (6) EP2206778B1 (ja)
JP (8) JP5098028B2 (ja)
KR (1) KR101420740B1 (ja)
CN (4) CN103113463B (ja)
AU (1) AU2006325975B2 (ja)
BR (1) BRPI0619794B8 (ja)
CA (1) CA2632142C (ja)
DK (1) DK1970446T3 (ja)
EA (2) EA014166B1 (ja)
ES (1) ES2367525T3 (ja)
HK (2) HK1125131A1 (ja)
IL (1) IL191903A (ja)
MX (2) MX2008007654A (ja)
NZ (1) NZ569530A (ja)
PT (1) PT1970446E (ja)
WO (1) WO2007069666A1 (ja)
ZA (1) ZA200804673B (ja)

Families Citing this family (570)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20030376A1 (it) 2003-07-31 2005-02-01 Univ Roma Procedimento per l'isolamento e l'espansione di cellule staminali cardiache da biopsia.
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
US9945840B2 (en) 2004-04-07 2018-04-17 Axiogenesis Ag Non-invasive, in vitro functional tissue assay systems
WO2005108598A1 (en) 2004-05-11 2005-11-17 Axiogenesis Ag Assay for drug discovery based on in vitro differentiated cells
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
US20100167404A1 (en) * 2005-08-03 2010-07-01 Advanced Cell Technology, Inc. Methods of Reprogramming Animal Somatic Cells
US9012219B2 (en) * 2005-08-23 2015-04-21 The Trustees Of The University Of Pennsylvania RNA preparations comprising purified modified RNA for reprogramming cells
US9157066B2 (en) 2005-12-13 2015-10-13 The Trustees Of The University Of Pennsylvania Transcriptome transfer produces cellular phenotype conversion
DK3467112T3 (da) 2005-12-13 2020-11-30 Univ Pennsylvania Fremgangsmåder til transfektion af nukleinsyrer til levende celler
MX2008007654A (es) 2005-12-13 2008-09-26 Univ Kyoto Factor de reprogramacion nuclear.
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US10647960B2 (en) * 2005-12-13 2020-05-12 The Trustees Of The University Of Pennsylvania Transcriptome transfer produces cellular phenotype conversion
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
US8173374B2 (en) 2006-03-06 2012-05-08 Agency For Science, Technology And Research Human embryonic stem cell methods and PODXL expression
WO2008102602A1 (ja) * 2007-02-22 2008-08-28 The University Of Tokyo Ｂｌａｓｔｏｃｙｓｔ ｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法
JP5813321B2 (ja) 2007-03-23 2015-11-17 ウィスコンシン アラムニ リサーチ ファンデーション 体細胞の再プログラム化
AU2008236629B2 (en) * 2007-04-07 2014-03-06 Whitehead Institute For Biomedical Research Reprogramming of somatic cells
AU2016216711B2 (en) * 2007-04-07 2018-01-25 Whitehead Institute For Biomedical Research Reprogramming of somatic cells
WO2008150814A2 (en) * 2007-05-29 2008-12-11 Reid Christopher B Methods for production and uses of multipotent cell populations
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) * 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
CA2695225C (en) 2007-07-31 2021-06-01 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic endocrine
US20120282229A1 (en) * 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
CN101855338B (zh) 2007-08-31 2013-07-17 怀特黑德生物医学研究所 在程序重排体细胞中的wnt途径刺激
WO2009057831A1 (ja) * 2007-10-31 2009-05-07 Kyoto University 核初期化方法
JP5710264B2 (ja) 2007-11-27 2015-04-30 ライフスキャン・インコーポレイテッドＬｉｆｅｓｃａｎ，Ｉｎｃ． ヒト胚性幹細胞の分化
EP2227540A4 (en) * 2007-11-29 2011-11-02 Children S Hospital Of Orange County DIFFERENTIATION OF HUMAN CELLS
JP5626619B2 (ja) * 2008-12-08 2014-11-19 国立大学法人京都大学 効率的な核初期化方法
AU2008286249B2 (en) 2007-12-10 2013-10-10 Kyoto University Efficient method for nuclear reprogramming
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
EP2235161A1 (en) 2007-12-11 2010-10-06 Research Development Foundation Small molecules for neuronal differentiation of embryonic stem cells
EP2072618A1 (en) * 2007-12-14 2009-06-24 Johannes Gutenberg-Universität Mainz Use of RNA for reprogramming somatic cells
KR101481164B1 (ko) * 2008-01-30 2015-01-09 주식회사 미래셀바이오 체세포 유래 다능성 줄기세포의 제조 방법
WO2009096049A1 (ja) * 2008-02-01 2009-08-06 Kyoto University 人工多能性幹細胞由来分化細胞
CA2959401C (en) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Methods, surface modified plates and compositions for cell attachment, cultivation and detachment
US20110067125A1 (en) * 2008-02-22 2011-03-17 The University Of Tokyo Method for producing founder animal for reproducing animal having lethal phenotype caused by gene modification
JP2009215191A (ja) 2008-03-07 2009-09-24 Keio Gijuku 神経損傷治療剤及び神経損傷治療方法
EP2100954A1 (en) * 2008-03-10 2009-09-16 Assistance Publique - Hopitaux de Paris Method for generating primate cardiac progenitor cells for clinical use from primate embryonic stem cells, and their applications
AU2015201026B2 (en) * 2008-03-17 2017-03-16 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
BRPI0908708A2 (pt) * 2008-03-17 2019-09-24 Scripps Research Inst métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desdiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de células tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de célula tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, composição, e, kit
WO2009114949A1 (en) * 2008-03-20 2009-09-24 UNIVERSITé LAVAL Methods for deprogramming somatic cells and uses thereof
US8765465B2 (en) 2008-03-26 2014-07-01 Kyoto University Efficient production and use of highly cardiogenic progenitors and cardiomyocytes from embryonic and induced pluripotent stem cells
WO2009119105A1 (ja) * 2008-03-28 2009-10-01 国立大学法人東京大学 ＧＰＩｂα＋ＧＰＶ＋ＧＰＶＩ＋血小板のインビトロ調製法
US20110117645A1 (en) * 2008-03-31 2011-05-19 Oriental Yeast Co., Ltd. Method for proliferation of pluripotent stem cells
JP5617631B2 (ja) * 2008-04-01 2014-11-05 国立大学法人東京大学 ｉＰＳ細胞からの血小板の調製方法
WO2009146098A2 (en) * 2008-04-02 2009-12-03 President And Fellows Of Harvard College Stem cells and uses thereof
JP2011522514A (ja) * 2008-04-07 2011-08-04 ニューポテンシャル，インコーポレイテッド Ｒｎａ干渉を介する多能性遺伝子の誘発による細胞の再プログラミング
US20100021437A1 (en) * 2008-04-07 2010-01-28 The McLean Hospital Corporation Whitehead Institute for Biomedical Research Neural stem cells derived from induced pluripotent stem cells
US8623648B2 (en) * 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
KR101481165B1 (ko) * 2008-04-25 2015-01-09 주식회사 미래셀바이오 인간 체세포 유래 다능성 줄기세포의 제조 방법
CA2695522C (en) 2008-05-02 2019-01-15 Kyoto University Method of nuclear reprogramming
WO2009136867A1 (en) * 2008-05-06 2009-11-12 Agency For Science, Technology And Research Method of effecting de-differentiation of a cell
CA2723820A1 (en) * 2008-05-09 2009-11-12 Vistagen Therapeutics, Inc. Pancreatic endocrine progenitor cells derived from pluripotent stem cells
WO2009142717A2 (en) * 2008-05-19 2009-11-26 President And Fellows Of Harvard College Methods and products for dedifferentiation of cells
EP2128245A1 (en) * 2008-05-27 2009-12-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Generation of induced pluripotent stem (iPS) cells
JP2011160661A (ja) * 2008-06-02 2011-08-25 Kyowa Hakko Kirin Co Ltd 血球細胞の初期化法
EP3447128A1 (en) * 2008-06-04 2019-02-27 FUJIFILM Cellular Dynamics, Inc. Methods for the production of ips cells using non-viral approach
AU2015202237B2 (en) * 2008-06-13 2017-09-28 Whitehead Institute For Biomedical Research Programming and reprogramming of cells
SG191673A1 (en) * 2008-06-13 2013-07-31 Whitehead Biomedical Inst Programming and reprogramming of cells
WO2010008486A2 (en) 2008-06-24 2010-01-21 Parkinsons Institute Pluripotent cell lines and methods of use thereof
WO2009157610A1 (en) * 2008-06-26 2009-12-30 Pusan National University Industry-University Cooperation Foundation Selenium dedifferentiated cell, preparation method and usage thereof
JP2011525794A (ja) * 2008-06-26 2011-09-29 国立大学法人大阪大学 ｉＰＳ細胞の製造方法および製造キット
KR101606943B1 (ko) * 2008-06-27 2016-03-28 고쿠리츠 다이가쿠 호진 교토 다이가쿠 유도된 다능성 줄기 세포의 효율적인 확립 방법
US20100015711A1 (en) 2008-06-30 2010-01-21 Janet Davis Differentiation of Pluripotent Stem Cells
CN104962583B (zh) 2008-07-16 2019-11-01 株式会社爱迪药业 使用染色体非整合型病毒载体制造经初始化的细胞的方法
US9528092B2 (en) * 2008-07-30 2016-12-27 Kyoto University Methods of efficiently establishing induced pluripotent stem cells under hypoxic conditions
KR101372752B1 (ko) * 2008-07-31 2014-03-14 고꾸리츠 다이가꾸호오징 기후다이가꾸 유도된 다능성 줄기 세포의 효율적인 확립 방법
JP5671737B2 (ja) 2008-08-05 2015-02-18 学校法人慶應義塾 分化細胞由来多能性幹細胞由来の二次ニューロスフェアの選択方法、その選択方法によって選択されたクローン、及びそのクローンの使用方法
EP2315829B1 (en) * 2008-08-08 2015-02-11 Mayo Foundation For Medical Education And Research Induced pluripotent stem cells
KR101773345B1 (ko) * 2008-08-12 2017-08-31 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 ｉＰＳ 세포의 생산 방법
JP2012500801A (ja) * 2008-08-21 2012-01-12 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ Ｃｎｓ疾患の治療法
US20110258715A1 (en) * 2008-08-22 2011-10-20 The University Of Tokyo ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION
EP2333050A4 (en) 2008-09-04 2013-07-03 Riken IPS CELLS FROM LYMPHOCYTES B AND APPLICATION THEREOF
US20110293578A1 (en) * 2008-09-04 2011-12-01 Case Western Reserve University Use of Stem Cells to Prevent Neuronal Dieback
US8945922B2 (en) 2008-09-08 2015-02-03 Riken Generating a mature NKT cell from a reprogrammed somatic cell with a T-cell antigen receptor α-chain region rearranged to uniform Va-Ja in a NKT-cell specific way
EP2344646A2 (en) * 2008-09-12 2011-07-20 Scarab Genomics, LLC Clean genome bactofection
CN101492676B (zh) * 2008-09-16 2011-02-16 中国科学院广州生物医药与健康研究院 用脑膜细胞生成诱导的多能性干细胞的方法及其用途
SG160248A1 (en) * 2008-09-18 2010-04-29 Agency Science Tech & Res Use of novel monoclonal antibodies targeting human embryonic stem cells to characterize and kill induced pluripotent stem cells
US8703413B2 (en) 2008-09-22 2014-04-22 Children's Medical Center Corporation Detection of human somatic cell reprogramming
US20110207215A1 (en) * 2008-10-24 2011-08-25 Kuraray Co., Ltd. Cell storage method and cell transport method
WO2010050626A1 (en) * 2008-10-30 2010-05-06 Kyoto University Method for producing induced pluripotent stem cells
CA2742267C (en) 2008-10-31 2019-06-04 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
RU2522001C2 (ru) 2008-10-31 2014-07-10 Сентокор Орто Байотек Инк. Дифференцирование человеческих эмбриональных стволовых клеток в линию панкреатических эндокринных клеток
JP5608645B2 (ja) 2008-11-05 2014-10-15 学校法人慶應義塾 神経幹細胞製造方法
EP2366021B1 (en) 2008-11-20 2017-08-02 Janssen Biotech, Inc. Pluripotent stem cell culture on micro-carriers
AU2009316583B2 (en) 2008-11-20 2016-04-21 Janssen Biotech, Inc. Methods and compositions for cell attachment and cultivation on planar substrates
EP2881461A1 (en) * 2008-11-21 2015-06-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Reprogramming cells toward a pluripotent state
JP6093110B2 (ja) * 2008-12-17 2017-03-08 ザ スクリプス リサーチ インスティテュート 幹細胞の作製と維持
CA2688804A1 (en) 2008-12-17 2010-06-17 The Uab Research Foundation Polycistronic vector for human induced pluripotent stem cell production
EP2377926A4 (en) * 2008-12-18 2011-12-14 New Ind Res Organization CHONDROCYTE TYPE CELL, AND PROCESS FOR PRODUCING THE SAME
US8470308B2 (en) * 2009-01-03 2013-06-25 Ray C. Wasielewski Enhanced medical implant comprising disrupted tooth pulp and tooth particles
US10328103B2 (en) 2009-01-03 2019-06-25 Ray C. Wasielewski Medical treatment composition comprising mammalian dental pulp stem cells
KR20110106468A (ko) 2009-02-03 2011-09-28 각고호우징 게이오기주크 인간 분화 세포-유래 다능성 줄기세포로부터 유래된 배아체 및/또는 신경 줄기세포의 배양방법
US20100209404A1 (en) * 2009-02-10 2010-08-19 University Of Dayton Enhanced method for producing stem-like cells from somatic cells
KR101764100B1 (ko) * 2009-02-27 2017-08-02 고쿠리츠 다이가쿠 호진 교토 다이가쿠 신규한 핵 재프로그래밍 물질
ES2900277T3 (es) * 2009-03-20 2022-03-16 Mesoblast Inc Producción de células pluripotentes reprogramadas
JP5637354B2 (ja) * 2009-03-30 2014-12-10 独立行政法人産業技術総合研究所 精製転写因子の調製法と細胞導入技術
CN101613717B (zh) * 2009-04-17 2012-01-11 中国科学院广州生物医药与健康研究院 用猪成纤维细胞生成诱导的多能性干细胞的方法
JPWO2010119819A1 (ja) 2009-04-17 2012-10-22 国立大学法人東北大学 ヒト肺組織幹細胞の調製方法及びヒト肺胞上皮細胞への分化誘導方法
CN101580816B (zh) * 2009-04-23 2012-02-29 中国科学院广州生物医药与健康研究院 诱导多能性干细胞快速高效产生的新型无血清培养基以及使用其的方法
JP2010268789A (ja) 2009-04-24 2010-12-02 Kumamoto Univ 細胞医薬の製造方法
EP2253700A1 (en) 2009-05-13 2010-11-24 Helmholtz-Zentrum für Infektionsforschung GmbH A method for producing test systems from donors suffering from adverse effects of medicaments and /or medical treatments, and uses of said systems
JP5922017B2 (ja) 2009-05-18 2016-05-24 クルナ・インコーポレーテッド リプログラミング因子に対する天然アンチセンス転写物の抑制によるリプログラミング因子関連疾患の治療
US9045738B2 (en) 2009-05-29 2015-06-02 Kyoto University Method for producing induced pluripotent stem cells and method for culturing the same
WO2010137348A1 (en) 2009-05-29 2010-12-02 Keio University Method for selecting clone of induced pluripotent stem cells
US9365866B2 (en) 2009-06-03 2016-06-14 National Institute Of Advanced Industrial Science And Technology Vectors for generating pluripotent stem cells and methods of producing pluripotent stem cells using the same
US20110002897A1 (en) * 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
US9399758B2 (en) 2009-07-15 2016-07-26 Mari Dezawa SSEA3(+) pluripotent stem cell that can be isolated from body tissue
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
KR102058901B1 (ko) 2009-07-20 2019-12-24 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
WO2011010449A1 (ja) * 2009-07-21 2011-01-27 国立大学法人京都大学 画像処理装置、培養観察装置、及び画像処理方法
JP5376478B2 (ja) * 2009-08-07 2013-12-25 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
JP5751548B2 (ja) 2009-08-07 2015-07-22 国立大学法人京都大学 イヌｉＰＳ細胞及びその製造方法
CN101993495B (zh) 2009-08-12 2013-07-24 上海近岸科技有限公司 一种蛋白质混合物及其制备方法
ES2590036T3 (es) 2009-08-12 2016-11-17 Kyoto University Método para inducir la diferenciación de células madre pluripotentes en células precursoras neurales
WO2011021706A1 (ja) 2009-08-19 2011-02-24 国立大学法人東北大学 角膜移植用シート
ES2972747T3 (es) 2009-08-22 2024-06-14 Ares Trading Sa Obtención de imágenes y evaluación de embriones, ovocitos y células madre
US20110052549A1 (en) * 2009-08-27 2011-03-03 The Regents Of The University Of California Cell culture device to differentiate stem cells in a specific orientation
JP5514215B2 (ja) 2009-08-31 2014-06-04 国立大学法人大阪大学 口腔粘膜由来細胞を利用した誘導多能性幹細胞の効率的な製造方法
WO2011028880A2 (en) 2009-09-04 2011-03-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods for enhancing genome stability and telomere elongation in embryonic stem cells
GB0915523D0 (en) * 2009-09-07 2009-10-07 Genome Res Ltd Cells and methods for obtaining them
US8741644B2 (en) 2009-09-08 2014-06-03 Kyoto University Method for producing mast cells from pluripotent stem cells
US20120263689A1 (en) * 2009-09-10 2012-10-18 The Salk Institute For Biological Studies Adipose-derived induced pluripotent stem cells
AU2014240253B2 (en) * 2009-09-15 2017-08-03 The University Of Tokyo Novel Method for Producing Differentiated Cells
WO2011034073A1 (ja) * 2009-09-15 2011-03-24 国立大学法人東京大学 分化細胞の新規製造法
JP5773393B2 (ja) 2009-09-24 2015-09-02 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
WO2011040887A1 (en) 2009-09-30 2011-04-07 Agency For Science, Technology And Research A nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells
AU2010306627B2 (en) 2009-10-16 2014-07-17 The Scripps Research Institute Induction of pluripotent cells
AU2010312291A1 (en) * 2009-10-29 2012-06-21 Mcmaster University Generating induced pluripotent stem cells and progenitor cells from fibroblasts
GB0919773D0 (en) 2009-11-12 2009-12-30 Univ Nottingham Induced pluripotent stem cell
EP3633025B1 (en) 2009-11-12 2022-09-14 Technion Research & Development Foundation Ltd. Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
JP2013510563A (ja) 2009-11-13 2013-03-28 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 操作された微小胞を用いた真核細胞のリプログラミング
EP2501803B1 (en) 2009-11-19 2020-12-23 Agency For Science, Technology And Research Methods of enhancing pluripotentcy
EP2511366A4 (en) 2009-12-09 2014-04-30 Univ Kyoto NITROVINE MEDICINE FOR PROMOTING THE DIFFERENTIATION OF PLURIPOTENTAL STEM CELLS IN HEART MUSCLES
JP2011121949A (ja) 2009-12-14 2011-06-23 Kyoto Univ 筋萎縮性側索硬化症の予防および治療用医薬組成物
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
JP2011135864A (ja) * 2009-12-30 2011-07-14 Korea Univ Research & Business Foundation Ｏｃｔ４及びＢｍｉ１、またはその上位調節子を用いて体細胞から胚幹細胞類似細胞への逆分化を誘導する組成物及びこれを用いた胚幹細胞類似細胞の製造方法
KR101485840B1 (ko) 2010-01-06 2015-01-23 도쿠리츠 다이가쿠 호우진 돗토리 다이가쿠 마우스 인공염색체 벡터
US9005967B2 (en) 2010-01-22 2015-04-14 Kyoto University Myc variants improve induced pluripotent stem cell generation efficiency
EP2532741B1 (en) 2010-02-03 2018-04-04 Tetsuya Ishikawa Induced hepatic stem cell and process for production thereof, and applications of the cell
CA2789749C (en) 2010-02-16 2018-09-04 Kyoto University Method of efficiently establishing induced pluripotent stem cells
JP5840119B2 (ja) 2010-02-18 2016-01-06 国立大学法人大阪大学 誘導多能性幹細胞の製造方法
CN102791851B (zh) 2010-03-01 2017-07-14 詹森生物科技公司 纯化衍生自多能干细胞的细胞的方法
WO2011109026A1 (en) 2010-03-05 2011-09-09 Tissue Genesis, Inc. Methods and compositions to support tissue integration and inosculation of transplanted tissue and transplanted engineered penile tissue with adipose stromal cells
JP2013521760A (ja) * 2010-03-10 2013-06-13 国立大学法人京都大学 人工多能性幹細胞の選別方法
EP2553086B1 (en) 2010-03-31 2017-04-19 The Scripps Research Institute Reprogramming cells
CA2796599A1 (en) 2010-04-16 2011-10-20 Keio University Method for producing induced pluripotent stem cells
WO2011133661A2 (en) 2010-04-21 2011-10-27 Research Development Foundation Methods and compositions related to dopaminergic neuronal cells
US9845457B2 (en) 2010-04-30 2017-12-19 Cedars-Sinai Medical Center Maintenance of genomic stability in cultured stem cells
US9249392B2 (en) 2010-04-30 2016-02-02 Cedars-Sinai Medical Center Methods and compositions for maintaining genomic stability in cultured stem cells
CN102242146B (zh) * 2010-05-10 2015-11-25 高丽大学校产学协力团 组合物和用其产生诱导全能干细胞的方法
SG10201503652WA (en) 2010-05-12 2015-08-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
CN102906249A (zh) 2010-05-25 2013-01-30 独立行政法人国立癌症研究中心 能够在体外自我复制的诱导性前癌干细胞或诱导性恶性干细胞，这些细胞的制备方法，及这些细胞的应用
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
US8932857B2 (en) 2010-06-15 2015-01-13 Kyoto University Method for selecting reduced differentiation resistance human induced pluripotent stem cells
JP6039551B2 (ja) * 2010-06-18 2016-12-07 セルラー ダイナミクス インターナショナル， インコーポレイテッド 透析された血清を有する心筋細胞培地
EP2594643B1 (en) 2010-07-12 2017-04-12 National University Corporation Tottori University Method for producing novel hipsc by means of sirna introduction
EP2596096B1 (en) 2010-07-21 2018-01-31 Kyoto University Method for inducing differentiation of human pluripotent stem cell into intermediate mesoderm cell
WO2012019168A2 (en) 2010-08-06 2012-02-09 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
EP2603583B1 (en) 2010-08-13 2016-10-05 Kyoto University Method of inducing differentiation from pluripotent stem cells to germ cells
CA2838330C (en) 2010-08-23 2021-01-26 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
JP5930205B2 (ja) 2010-08-26 2016-06-08 国立大学法人京都大学 多能性幹細胞の心筋分化促進剤
KR20130093624A (ko) 2010-08-30 2013-08-22 디나벡크 가부시키가이샤 다능성 줄기 세포를 유도하기 위한 조성물 및 그의 사용
WO2012030540A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
CA2809303C (en) 2010-08-31 2024-04-09 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
RU2620938C2 (ru) 2010-08-31 2017-05-30 Янссен Байотек, Инк. Дифференцирование эмбриональных стволовых клеток человека
US9856210B2 (en) 2010-09-02 2018-01-02 Kyoto University Pharmaceutical composition for prevention and treatment of amyotrophic lateral sclerosis
EP2616540A4 (en) 2010-09-14 2014-02-19 Univ Kyoto METHOD OF EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
US20130296183A1 (en) 2010-09-17 2013-11-07 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
EP2622064B1 (en) 2010-10-01 2019-05-29 Modernatx, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
US20130295064A1 (en) * 2010-10-14 2013-11-07 University Of Central Florida Research Foundation, Inc. Cardiac induced pluripotent stem cells and methods of use in repair and regeneration of myocardium
WO2012054896A1 (en) 2010-10-22 2012-04-26 Biotime Inc. Methods of modifying transcriptional regulatory networks in stem cells
JP6044932B2 (ja) * 2010-10-25 2016-12-14 公立大学法人横浜市立大学 幹細胞の安定的維持、複製を制御するためのペプチジルプロリルイソメラーゼＰｉｎ１の利用
CN103459591B (zh) 2010-11-02 2016-05-04 国立大学法人熊本大学 肠细胞的制造方法
WO2012060473A1 (en) * 2010-11-04 2012-05-10 Kyoto University Method of efficiently establishing induced pluripotent stem cells
US20130225443A1 (en) 2010-11-05 2013-08-29 Kyoto University Method of examining polycystic kidney disease and method of screening for therapeutic agent of the disease
WO2012063817A1 (ja) * 2010-11-09 2012-05-18 独立行政法人産業技術総合研究所 末梢血単球由来多能性幹細胞作製方法
US9074188B2 (en) 2010-11-17 2015-07-07 Kyoto University Cardiomyocyte- and/or cardiac progenitor cell-proliferating agent and method for proliferating cardiomyocytes and/or cardiac progenitor cells
WO2012074116A1 (ja) 2010-12-02 2012-06-07 独立行政法人理化学研究所 アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体（TCR）遺伝子のα鎖領域が均一なVα-Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング
EP2647698A4 (en) 2010-12-03 2015-10-07 Univ Kyoto PROCESS FOR PRODUCING EOSINOPHILES FROM PLURIPOTENT STEM CELLS
EP2647699B1 (en) * 2010-12-03 2020-04-01 Kyoto University Efficient method for establishing induced pluripotent stem cells
JP5888852B2 (ja) * 2010-12-08 2016-03-22 学校法人近畿大学 免疫不全動物を用いた細胞の製法
CA2822638C (en) 2010-12-22 2021-02-16 Fate Therapeutics, Inc. Cell culture platform for single cell sorting and enhanced reprogramming of ipscs
US9850466B2 (en) 2011-01-19 2017-12-26 The Regents Of The University Of California Somatic cells with innate potential for pluripotency
WO2012098260A1 (en) 2011-01-21 2012-07-26 Axiogenesis Ag A non-viral system for the generation of induced pluripotent stem (ips) cells
WO2012112458A2 (en) * 2011-02-14 2012-08-23 The Regents Of The University Of California Compositions and methods for increasing reprogramming efficiency
EP2678425B1 (en) 2011-02-23 2017-08-23 Kyoto University Method for producing dendritic cells from pluripotent stem cells
US9879307B2 (en) 2011-02-23 2018-01-30 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
GB201103600D0 (en) 2011-03-01 2011-04-13 Isis Innovation Dendritic cells
JP2014514921A (ja) 2011-03-30 2014-06-26 独立行政法人理化学研究所 機能性核酸分子、及びその利用
US9156900B2 (en) 2011-03-31 2015-10-13 Riken Control agent for controlling undifferentiated state and use thereof
US8710200B2 (en) 2011-03-31 2014-04-29 Moderna Therapeutics, Inc. Engineered nucleic acids encoding a modified erythropoietin and their expression
JP6025067B2 (ja) 2011-03-31 2016-11-16 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 新規心筋細胞マーカー
EP3415616B1 (en) 2011-04-08 2024-05-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Method for rejuvenating cells
CN103649112B (zh) 2011-04-08 2017-07-18 国立大学法人大阪大学 改造层粘连蛋白及其利用
WO2012141181A1 (ja) * 2011-04-11 2012-10-18 国立大学法人京都大学 核初期化物質
CN103492555A (zh) 2011-04-20 2014-01-01 国立大学法人大阪大学 角膜上皮分化取向性iPS细胞
CA2835825C (en) 2011-05-13 2021-03-23 Minoru S.H. Ko Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells
WO2012168434A1 (en) 2011-06-08 2012-12-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Partial reprogramming of somatic cells to induced tissue stem (its) cells
GB201110331D0 (en) 2011-06-16 2011-08-03 Isis Innovation Method of cryopreserving pluripotent stem cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
WO2013014057A1 (en) 2011-07-22 2013-01-31 Centre National De La Recherche Scientifique Use of cellular extracts for obtaining pluripotent stem cells
US20130029416A1 (en) 2011-07-22 2013-01-31 Tayaramma Thatava Differentiating induced pluripotent stem cells into glucose-responsive, insulin-secreting progeny
US9677141B2 (en) 2011-07-25 2017-06-13 Kyoto University Method for screening induced pluripotent stem cells
WO2013031826A1 (ja) * 2011-08-29 2013-03-07 国立大学法人京都大学 核初期化物質
US9145547B2 (en) 2011-08-30 2015-09-29 Riken Nuclear reprogrammed cells generated by introduction of a histone H2aa or TH2A gene, a histone H2ba or TH2B gene, or a phosphorylation-mimic of histone chaperon Npm2 gene, an Oct family gene and a klf family gene into a mammalian somatic cell
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
JP6028236B2 (ja) 2011-09-12 2016-11-16 国立大学法人 熊本大学 物質のスクリーニング方法
EP2762560A4 (en) * 2011-09-29 2015-05-20 Univ Tokyo PROCESS FOR INDUCING OREXINE NEURONES
US9480695B2 (en) 2011-09-29 2016-11-01 The University Of Tokyo Methods for inducing orexin neurons and agent for treating narcolepsy or eating disorder
HRP20220250T1 (hr) 2011-10-03 2022-04-29 Modernatx, Inc. Modificirani nukleozidi, nukleotidi i nukleinske kiseline, te njihove uporabe
EP2770051B1 (en) 2011-10-21 2017-09-27 ARKRAY, Inc. Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow
GB2496375A (en) 2011-10-28 2013-05-15 Kymab Ltd A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof
US8945876B2 (en) 2011-11-23 2015-02-03 University Of Hawaii Auto-processing domains for polypeptide expression
EP2784153B1 (en) 2011-11-25 2018-01-03 Kyoto University Method for culturing pluripotent stem cell
CA2853645A1 (en) 2011-11-30 2013-06-06 National Cancer Center Induced malignant stem cells
GB201122047D0 (en) 2011-12-21 2012-02-01 Kymab Ltd Transgenic animals
US8497124B2 (en) 2011-12-05 2013-07-30 Factor Bioscience Inc. Methods and products for reprogramming cells to a less differentiated state
BR112014013664A2 (pt) 2011-12-05 2020-11-03 Factor Bioscience Inc. métodos e produtos para transfectar células
EP2791160B1 (en) 2011-12-16 2022-03-02 ModernaTX, Inc. Modified mrna compositions
EP2794860B1 (en) 2011-12-19 2017-05-03 Kyoto University Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells
EP2794857A4 (en) 2011-12-22 2015-07-08 Janssen Biotech Inc DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS IN SINGLE INSULIN POSITIVE CELLS
CN104039954B (zh) 2011-12-27 2017-03-15 国立大学法人大阪大学 可抑制iPS细胞的肿瘤化的分化诱导方法
EP2804944A1 (en) 2012-01-15 2014-11-26 Yeda Research and Development Co. Ltd. Induction of dedifferentiation of mesenchymal stromal cells
JP6274510B2 (ja) 2012-01-27 2018-02-07 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
MX354775B (es) 2012-03-07 2018-03-20 Janssen Biotech Inc Medios definidos para la expansion y el mantenimiento de celulas madre pluripotentes.
JP5920741B2 (ja) 2012-03-15 2016-05-18 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法
WO2013140927A1 (ja) 2012-03-21 2013-09-26 国立大学法人京都大学 アルツハイマー病の治療薬および/または予防薬のスクリーニング方法
EP2828381A1 (en) 2012-03-21 2015-01-28 Rheinische Friedrich-Wilhelms-Universität Bonn Induced neural stem cells
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
EP2834259A4 (en) 2012-04-02 2016-08-24 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES
JP6112733B2 (ja) 2012-04-06 2017-04-12 国立大学法人京都大学 エリスロポエチン産生細胞の誘導方法
US10195229B2 (en) * 2012-04-19 2019-02-05 Elsa R. Flores Generation of human induced pluripotent stem cells using nucleic acid sequences that inhibit Δ-NP63 and DGCR8
CA2874259C (en) 2012-05-23 2021-02-09 Kyoto University Highly efficient method for establishing induced pluripotent stem cell
ES2636902T3 (es) 2012-05-25 2017-10-10 The Regents Of The University Of California Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN
CA2875038A1 (en) 2012-05-31 2013-12-05 Auxogyn, Inc. In vitro embryo blastocyst prediction methods
US9884076B2 (en) 2012-06-05 2018-02-06 Capricor, Inc. Optimized methods for generation of cardiac stem cells from cardiac tissue and their use in cardiac therapy
AU2013271581B2 (en) 2012-06-08 2018-08-09 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
JP2015528001A (ja) 2012-07-11 2015-09-24 ティッシュテック，インク． Ｈｃ−ｈａ／ｐｔｘ３複合体を含む組成物およびその使用方法
WO2014014119A1 (en) 2012-07-17 2014-01-23 Kyoto University Novel cardiomyocyte marker
KR102055438B1 (ko) 2012-07-31 2019-12-19 에이지엑스 쎄라퓨틱스, 인크. Hla g-변형된 세포 및 방법
AU2013302799B2 (en) 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
US20150267174A1 (en) * 2012-10-09 2015-09-24 Nakanobu Hayashi Reprogramming peptide and use thereof
JP2014082956A (ja) 2012-10-19 2014-05-12 Somar Corp 細胞培養基材、およびそれを用いた細胞培養方法並びに多能性幹細胞の分化誘導方法
SG11201503167XA (en) * 2012-10-23 2015-05-28 Univ Kyoto Method of efficiently establishing induced pluripotent stem cells
CA2889232C (en) 2012-10-30 2018-05-15 Daiichi Sankyo Company, Limited Mait-like cells and their preparation method
CA3150985A1 (en) 2012-11-01 2014-05-08 Factor Bioscience Inc. Methods and products for expressing proteins in cells
ES2921623T3 (es) 2012-11-26 2022-08-30 Modernatx Inc ARN modificado terminalmente
GB201222693D0 (en) * 2012-12-17 2013-01-30 Babraham Inst Novel method
WO2014103137A1 (ja) 2012-12-27 2014-07-03 ソニー株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
WO2014104364A1 (ja) 2012-12-28 2014-07-03 国立大学法人京都大学 人工多能性幹細胞、心筋細胞又はその前駆細胞の製造方法
CN105008518B (zh) 2012-12-31 2020-08-07 詹森生物科技公司 在空气-液体界面处培养人胚胎干细胞以用于分化成胰腺内分泌细胞
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
RU2684215C2 (ru) 2012-12-31 2019-04-04 Янссен Байотек, Инк. Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток
WO2014106141A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
EP2947157B1 (en) 2013-01-16 2017-09-13 Universal Bio Research Co., Ltd. Method for identifying cells
US10241108B2 (en) 2013-02-01 2019-03-26 Ares Trading S.A. Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower development potential
CA2899865C (en) 2013-02-01 2023-10-10 Kapil BHARTI Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)
WO2014124087A1 (en) 2013-02-06 2014-08-14 University Of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
WO2014123242A1 (ja) 2013-02-08 2014-08-14 国立大学法人京都大学 巨核球及び血小板の製造方法
JP6494903B2 (ja) 2013-02-14 2019-04-03 ソニー株式会社 分析システム、分析プログラム及び分析方法
WO2014133170A1 (ja) 2013-03-01 2014-09-04 株式会社Ｃｌｉｏ 多能性幹細胞を損傷部位に誘導する遊走因子を含む医薬組成物
WO2014136581A1 (ja) 2013-03-06 2014-09-12 国立大学法人京都大学 多能性幹細胞の培養システム及び多能性幹細胞の継代方法
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
EP2970897B1 (en) 2013-03-14 2019-11-27 The Regents of The University of California In vitro production of medial ganglionic eminence precursor cells
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP2977449B1 (en) 2013-03-21 2020-02-26 Kyoto University Pluripotent stem cell for neuronal differentiation induction
EP2980207B1 (en) 2013-03-25 2018-12-05 Foundation for Biomedical Research and Innovation at Kobe Cell sorting method
GB201306589D0 (en) 2013-04-11 2013-05-29 Abeterno Ltd Live cell imaging
CA2909230C (en) 2013-04-12 2021-06-15 Kyoto University Method for inducing alveolar epithelial progenitor cells
EP2998391B1 (en) 2013-05-14 2020-02-19 Kyoto University Efficient myocardial cell induction method
JP5862915B2 (ja) 2013-05-31 2016-02-16 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 ハイドロゲルを組み込んだ積層化細胞シート
WO2014200905A2 (en) 2013-06-10 2014-12-18 President And Fellows Of Harvard College Early developmental genomic assay for characterizing pluripotent stem cell utility and safety
CA2915085C (en) 2013-06-11 2021-04-27 Kyoto University Method for producing renal progenitor cells and drug comprising the same
JP6493881B2 (ja) 2013-06-12 2019-04-03 国立大学法人京都大学 人工多能性幹細胞の選別方法および血球への分化誘導方法
EP3031905A4 (en) 2013-08-07 2017-04-26 Kyoto University Method for producing pancreatic hormone-producing cell
WO2015025959A1 (ja) 2013-08-23 2015-02-26 独立行政法人理化学研究所 蛍光特性を示すポリペプチド、およびその利用
JP6617231B2 (ja) 2013-08-28 2019-12-11 国立大学法人岐阜大学 人工多能性幹細胞の作製方法
JPWO2015030149A1 (ja) 2013-08-29 2017-03-02 国立大学法人鳥取大学 細胞のアンチエイジングに関連する生体分子群
EP3042194B1 (en) 2013-09-05 2019-11-27 Tempo Bioscience Inc. Human cellular models with biosensors
SG11201601720RA (en) 2013-09-05 2016-04-28 Univ Kyoto New method for inducing dopamine-producing neural precursor cells
WO2015037535A1 (ja) 2013-09-12 2015-03-19 株式会社カネカ 人工多能性幹細胞の分化誘導方法及び選別方法
EP3045451B1 (en) 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
WO2015046229A1 (ja) 2013-09-24 2015-04-02 ディナベック株式会社 多能性幹細胞の誘導効率を改善する方法
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
EP3052521A1 (en) 2013-10-03 2016-08-10 Moderna Therapeutics, Inc. Polynucleotides encoding low density lipoprotein receptor
WO2015064754A1 (ja) 2013-11-01 2015-05-07 国立大学法人京都大学 新規軟骨細胞誘導方法
WO2015066488A2 (en) 2013-11-01 2015-05-07 New England Biolabs, Inc. Method for producing induced pluripotent stem cells
WO2015068329A1 (ja) 2013-11-08 2015-05-14 ソニー株式会社 細胞分析システム、細胞分析プログラム及び細胞分析方法
US11767507B2 (en) 2013-11-08 2023-09-26 The Mclean Hospital Corporation Methods for efficient generation of GABAergic interneurons from pluripotent stem cells
CN104630136B (zh) * 2013-11-15 2019-10-01 中国科学院广州生物医药与健康研究院 一种制备诱导多能性干细胞的方法以及该方法中所使用的组合物及其应用
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
US20160298096A1 (en) 2013-11-18 2016-10-13 Crispr Therapeutics Ag Crispr-cas system materials and methods
JP6536871B2 (ja) 2013-12-02 2019-07-03 国立大学法人京都大学 Ｆｇｆｒ３病の予防および治療剤ならびにそのスクリーニング方法
KR102070967B1 (ko) * 2013-12-10 2020-01-29 한국한의학연구원 사군자탕을 유효성분으로 포함하는, 세포의 유도만능줄기세포로의 리프로그래밍 촉진용 조성물 및 이를 이용한 유도만능줄기세포의 제조방법
JP2017504311A (ja) 2013-12-11 2017-02-09 ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ 網膜色素上皮細胞を生成する方法
EP3835419A1 (en) 2013-12-12 2021-06-16 The Regents of The University of California Methods and compositions for modifying a single stranded target nucleic acid
US10100284B2 (en) 2013-12-25 2018-10-16 Toagosei Co. Ltd. Method for inducing differentiation of pluripotent stem cells into endodermal cells
EP2896688A1 (en) 2014-01-20 2015-07-22 Centre National de la Recherche Scientifique (CNRS) A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide
EP4249036A3 (en) 2014-01-31 2023-10-25 Factor Bioscience Inc. Methods and products for nucleic acid production and delivery
JP6722108B2 (ja) 2014-03-04 2020-07-15 フェイト セラピューティクス，インコーポレイテッド 改善された再プログラム方法及び細胞培養基盤
WO2015140257A1 (en) 2014-03-19 2015-09-24 INSERM (Institut National de la Santé et de la Recherche Médicale) A method for inducing human cholangiocyte differentiation
WO2015141827A1 (ja) 2014-03-20 2015-09-24 国立大学法人京都大学 心筋細胞の選別方法
WO2015143350A1 (en) 2014-03-20 2015-09-24 Auxogyn, Inc. Quantitative measurement of human blastocyst and morula morphology developmental kinetics
JP6197947B2 (ja) * 2014-03-31 2017-09-20 味の素株式会社 幹細胞用培地
BR112016026626A2 (pt) 2014-05-16 2017-08-15 Janssen Biotech Inc Uso de moléculas pequenas para melhorar a expressão de mafa em células pancreáticas endócrinas
JP6730608B2 (ja) 2014-05-21 2020-07-29 国立大学法人京都大学 膵芽細胞の製造方法および膵芽細胞を含む膵疾患治療剤
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
US9518103B2 (en) 2014-06-18 2016-12-13 President And Fellows Of Harvard College Optogenetic probes for measuring membrane potential
EP3159354B1 (en) 2014-06-23 2020-09-09 Toagosei Co., Ltd. Novel synthetic peptide and use thereof
WO2016010002A1 (ja) 2014-07-14 2016-01-21 中外製薬株式会社 タンパク質のエピトープを同定するための方法
WO2016036754A1 (en) 2014-09-02 2016-03-10 The Regents Of The University Of California Methods and compositions for rna-directed target dna modification
JP6452107B2 (ja) 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
WO2016054591A1 (en) 2014-10-03 2016-04-07 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
JP6598185B2 (ja) 2014-11-07 2019-10-30 国立大学法人京都大学 軟骨過形成疾患の予防および治療剤ならびにそのスクリーニング方法
AU2015353853B2 (en) 2014-11-25 2020-10-15 President And Fellows Of Harvard College Methods for generation of podocytes from pluripotent stem cells and cells produced by the same
PL3233129T3 (pl) 2014-12-17 2020-11-02 Fundacion Para La Investigacion Medica Aplicada Konstrukty kwasu nukleinowego i wektory terapii genowej do zastosowania w leczeniu choroby Wilsona i innych schorzeń
ES2876412T3 (es) 2014-12-17 2021-11-12 Fundacion Para La Investig Medica Aplicada Construcciones de ácido nucleico y vectores de terapia génica para su uso en el tratamiento de la enfermedad de Wilson
US10711249B2 (en) 2014-12-26 2020-07-14 Kyoto University Method for inducing hepatocytes
US10077463B2 (en) 2015-01-15 2018-09-18 President And Fellows Of Harvard College Optical selection of cells
TWI696700B (zh) 2015-01-16 2020-06-21 國立研究開發法人產業技術總合研究所 使用具有匿跡性之ｒｎａ的基因表現系統及含有該ｒｎａ的基因導入、表現載體
EP3256585A4 (en) 2015-02-13 2018-08-15 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
SI3059307T2 (sl) 2015-02-20 2022-08-31 Inserm(Institut National De La Sante Et De La Recherche Medicale) Uporaba laminina za diferenciacijo pluripotentnih celic v hepatocite
WO2016143803A1 (ja) 2015-03-06 2016-09-15 国立大学法人京都大学 肺胞上皮細胞の分化誘導法
WO2016148253A1 (ja) 2015-03-18 2016-09-22 小野薬品工業株式会社 ナイーブ型多能性幹細胞の製造方法
EP3283510B1 (en) 2015-04-14 2020-08-05 UAB Ferentis Collagen mimetic peptide
CN107709543B (zh) * 2015-04-14 2021-11-09 国立大学法人京都大学 制造适于向体细胞分化诱导的干细胞克隆的方法
EP3081638A1 (en) 2015-04-16 2016-10-19 Kyoto University Method for producing pseudo-islets
JP6935654B2 (ja) 2015-04-28 2021-09-15 東亞合成株式会社 合成ペプチドを用いた心筋細胞の生産方法
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
FR3037338B1 (fr) 2015-06-12 2020-02-28 Philippe Nirde Procede de greffe de cellule cardiaque sur la membrane choriallantoide d'œuf feconde
WO2017002300A1 (en) 2015-06-30 2017-01-05 Sony Corporation Information processing apparatus, information processing system, and information processing method
JP6746945B2 (ja) 2015-06-30 2020-08-26 ソニー株式会社 情報処理装置、情報処理システム及び情報処理方法
KR20180029976A (ko) * 2015-07-10 2018-03-21 하트 시드 가부시키가이샤 고품질 iPS 세포의 제조 방법
WO2017014165A1 (ja) 2015-07-17 2017-01-26 国立大学法人京都大学 血管内皮細胞の誘導方法
US11286454B2 (en) 2015-08-31 2022-03-29 I Peace, Inc. Pluripotent stem cell manufacturing system and method for producing induced pluripotent stem cells
PL3344758T3 (pl) 2015-09-01 2022-01-03 Ncardia B.V. Sposób in vitro różnicowania populacji ludzkich pluripotentnych komórek macierzystych w populację komórek kardiomiocytów
US11162070B2 (en) 2015-09-08 2021-11-02 FUJIFILM Cellular Dynamics, Inc. MACS-based purification of stem cell-derived retinal pigment epithelium
EP4345160A3 (en) 2015-09-08 2024-07-03 The United States of America, as represented by The Secretary, Department of Health and Human Services Method for reproducible differentiation of clinical-grade retinal pigment epithelium cells
CA2998096C (en) 2015-09-11 2024-01-30 Astellas Pharma Inc. Method for producing renal progenitor cells
CA2998287A1 (en) 2015-09-24 2017-04-20 Crispr Therapeutics Ag Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
JP6691756B2 (ja) 2015-09-29 2020-05-13 東亞合成株式会社 合成ペプチドを用いた神経幹細胞の生産方法
WO2017059241A1 (en) 2015-10-02 2017-04-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lentiviral protein delivery system for rna-guided genome editing
WO2017062401A1 (en) 2015-10-05 2017-04-13 ORIG3N Inc. Diagnosis and treatment of parkinson's disease based on identification and amelioration of liver dysfunction
US11441126B2 (en) 2015-10-16 2022-09-13 Fate Therapeutics, Inc. Platform for the induction and maintenance of ground state pluripotency
CA3002157A1 (en) 2015-10-20 2017-04-27 FUJIFILM Cellular Dynamics, Inc. Methods for directed differentiation of pluripotent stem cells to immune cells
JP2016011317A (ja) * 2015-10-21 2016-01-21 加治佐　功 ゲノム編集用クリスパーキャス９による老化遺伝子切り取り若返り経口不老不死薬７
EP3377635A4 (en) 2015-11-18 2019-05-08 Orbis Health Solutions LLC VIRAL VECTOR SYSTEM ALPHA T7
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
GB201601503D0 (en) 2016-01-27 2016-03-09 Isis Innovation Dendritic cells
EP3417061B1 (en) 2016-02-18 2022-10-26 The Regents of the University of California Methods and compositions for gene editing in stem cells
WO2017159862A1 (ja) 2016-03-18 2017-09-21 国立大学法人京都大学 多能性幹細胞由来心筋細胞の凝集体の凍結方法
US11773375B2 (en) 2016-03-25 2023-10-03 Ncardia B.V. In vivo method for differentiating human pluripotent stem cells into atrial cardiomyocytes
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
AU2017248985B2 (en) 2016-04-15 2023-01-12 Kyoto University Method for inducing antigen specific CD8 positive T cells
IL262475B2 (en) 2016-04-22 2023-11-01 Univ Kyoto A method for the production of neural precursor cells that produce dopamine
CA3024518C (en) 2016-05-16 2022-02-15 National University Corporation Nagoya University Amelioration and treatment of perinatal brain damage with pluripotent stem cells
US11351200B2 (en) 2016-06-03 2022-06-07 Cedars-Sinai Medical Center CDC-derived exosomes for treatment of ventricular tachyarrythmias
WO2017216771A2 (en) 2016-06-17 2017-12-21 Genesis Technologies Limited Crispr-cas system, materials and methods
WO2018005975A1 (en) 2016-07-01 2018-01-04 Research Development Foundation Elimination of proliferating cells from stem cell-derived grafts
EP3491134B1 (en) 2016-08-01 2023-10-11 University of Pittsburgh - of The Commonwealth System of Higher Education Human induced pluripotent stem cells for high efficiency genetic engineering
CN109689074A (zh) 2016-08-03 2019-04-26 株式会社生命科学研究院 采用多能干细胞的缺血再灌注肺损伤的减轻及治疗
EP3494978A4 (en) 2016-08-03 2020-03-11 National University Corporation Nagoya University IMPROVEMENT AND TREATMENT OF CHRONIC PULMONARY DISEASES USING PLURIPOTENT STEM CELLS
US10373109B2 (en) 2016-08-04 2019-08-06 Fanuc Corporation System and method for iPS cell bank using media
US10354218B2 (en) 2016-08-04 2019-07-16 Fanuc Corporation System and method for iPS cell bank using internet technology
US11259520B2 (en) 2016-08-04 2022-03-01 Fanuc Corporation Stem cell manufacturing system, stem cell information management system, cell transport apparatus, and stem cell frozen storage apparatus
AU2017312113B2 (en) 2016-08-17 2023-05-25 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
US11473057B2 (en) 2016-09-02 2022-10-18 Takara Bio Inc. Method for obtaining microglia from pluripotent stem cells
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
AU2017340634B2 (en) 2016-10-05 2022-06-02 FUJIFILM Cellular Dynamics, Inc. Generating mature lineages from induced pluripotent stem cells with MECP2 disruption
WO2018079857A1 (ja) 2016-10-31 2018-05-03 国立大学法人鳥取大学 ヒト抗体産生非ヒト動物及びそれを用いたヒト抗体作製法
CA3043194A1 (en) 2016-11-09 2018-05-17 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services 3d vascularized human ocular tissue for cell therapy and drug discovery
WO2018124118A1 (ja) 2016-12-27 2018-07-05 住友化学株式会社 人工多能性幹細胞の評価方法及び選抜方法、並びに人工多能性幹細胞の製造方法
WO2018135646A1 (ja) 2017-01-20 2018-07-26 国立大学法人京都大学 ＣＤ８α＋β＋細胞傷害性Ｔ細胞の製造方法
EP3575392A4 (en) 2017-01-26 2020-08-26 Osaka University MEDIUM FOR INDUCING THE DIFFERENTIATION OF STEM CELLS INTO MESODERMAL CELLS AND METHOD FOR PRODUCING MESODERMAL CELLS
CN110234754B (zh) 2017-01-27 2024-02-20 株式会社钟化 内胚层细胞团、和由多能细胞制造三胚层中的任意胚层的细胞团的方法
EP3578650A4 (en) 2017-02-06 2021-03-24 National Cancer Center Japan NEW T-LYMPHOCYTE RECEPTOR
EP3583201B1 (en) 2017-02-14 2024-01-17 University of Pittsburgh - Of the Commonwealth System of Higher Education Methods of engineering human induced pluripotent stem cells to produce liver tissue
US10828330B2 (en) 2017-02-22 2020-11-10 IO Bioscience, Inc. Nucleic acid constructs comprising gene editing multi-sites and uses thereof
CA3054119A1 (en) 2017-02-24 2018-08-30 I Peace, Inc. Cell treatment device, suspension culture vessel, and stem cell induction method
SG11201907406WA (en) 2017-02-27 2019-09-27 Koji Tanabe Cell processing system and cell processing device
JP6480093B2 (ja) 2017-02-27 2019-03-06 剛士 田邊 体細胞製造システム
US20190390169A1 (en) 2017-03-03 2019-12-26 Kyoto University Pancreatic progenitor cell production method
US11559548B2 (en) 2017-03-14 2023-01-24 Kyoto University Method for producing helper T cells from pluripotent stem cells
EP3604503A4 (en) 2017-03-28 2020-12-30 Ajinomoto Co., Inc. ADDITIVE FOR DE-DIFFERENTIATION SUPPORT MEDIUM
EP4083063A3 (en) 2017-04-18 2023-01-04 FUJIFILM Cellular Dynamics, Inc. Antigen-specific immune effector cells
US11759482B2 (en) 2017-04-19 2023-09-19 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
US20200197442A1 (en) * 2017-04-26 2020-06-25 Nsage Corp. Pharmaceutical composition for prevention or treatment of alzheimer's disease, comprising stem cell secreting srage
WO2018203499A1 (ja) 2017-05-02 2018-11-08 剛士 田邊 医薬品組成物及び化粧品組成物
KR102594102B1 (ko) 2017-05-25 2023-10-25 고쿠리츠 다이가쿠 호진 교토 다이가쿠 중간 중배엽 세포로부터 신장 전구 세포로의 분화 유도 방법 및 다능성 줄기세포로부터 신장 전구 세포로의 분화 유도 방법
EP3406712A1 (en) 2017-05-26 2018-11-28 Fundación Centro Nacional De Investigaciones Oncológicas Carlos III Method for expanding stemness and differentiation potential of pluripotent cells
WO2018230588A1 (ja) 2017-06-14 2018-12-20 武田薬品工業株式会社 細胞封入デバイス
EP3643780A4 (en) 2017-06-19 2021-04-07 Foundation for Biomedical Research and Innovation at Kobe METHOD FOR PREDICTING THE DIFFERENTIATION CAPACITY OF PLURIPOTENT STEM CELLS, AND ASSOCIATED REAGENT
JP6758631B2 (ja) 2017-06-19 2020-09-23 国立大学法人大阪大学 角膜内皮細胞マーカー及びその利用
AU2018289947A1 (en) 2017-06-20 2020-01-30 Life Science Institute, Inc. Amelioration and treatment of brain disorder resulting from fetal growth retardation using pluripotent stem cells
US10660523B2 (en) 2017-07-07 2020-05-26 Hideo Ando Light-source unit, measurement apparatus, near-infrared microscopic apparatus, optical detection method, imaging method, calculation method, functional bio-related substance, state management method, and manufacturing method
JP7140400B2 (ja) 2017-10-17 2022-09-21 国立大学法人京都大学 多能性幹細胞から人工神経筋接合部を得る方法
SG11202003507QA (en) 2017-10-17 2020-05-28 Univ Hiroshima Pluripotent stem cells inducing osteochondral repair
WO2019088257A1 (ja) 2017-11-02 2019-05-09 国立大学法人鳥取大学 哺乳類人工染色体ベクターを利用するタンパク質の高生産方法
WO2019092505A1 (en) 2017-11-09 2019-05-16 Casebia Therapeutics Llp Self-inactivating (sin) crispr/cas or crispr/cpf1 systems and uses thereof
JP7428653B2 (ja) 2017-11-15 2024-02-06 バーテックス ファーマシューティカルズ インコーポレイテッド 島細胞製造組成物および使用方法
TW201940693A (zh) 2017-11-30 2019-10-16 國立大學法人京都大學 細胞之培養方法
MA51138A (fr) 2017-12-14 2020-10-21 Bayer Healthcare Llc Nouveaux systèmes d'endonucléases arn-programmables et leurs utilisations dans l'édition de génome et d'autres applications
EP3727351A4 (en) 2017-12-20 2021-10-06 Cedars-Sinai Medical Center MODIFIED EXTRACELLULAR VESICLES FOR IMPROVED TISSUE DELIVERY
US11624049B2 (en) 2017-12-22 2023-04-11 Orizuru Therapeutics, Inc. Cell culturing apparatus, culture solution aspirator, and cell culturing method
EP3766980A4 (en) 2018-03-16 2021-05-05 National University Corporation Tottori University ARTIFICIAL CHROMOSOME VECTOR FROM THE MOUSE AND ITS USE
JPWO2019182157A1 (ja) 2018-03-19 2021-03-18 国立大学法人京都大学 ハイドロゲルカプセル
AU2019239957A1 (en) 2018-03-19 2020-09-10 Bayer Healthcare Llc Novel RNA-programmable endonuclease systems and uses thereof
US20210010030A1 (en) 2018-03-22 2021-01-14 Nserm (Institut National De La Santé Et De La Recherche Médicale) Method for reprogramming somatic cells
TWI820104B (zh) 2018-03-30 2023-11-01 日商千紙鶴治療公司 雜環化合物
WO2019189554A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 心筋細胞成熟促進剤
WO2019189758A1 (ja) 2018-03-30 2019-10-03 味の素株式会社 ポリリジン類縁体を含む、細胞増殖促進用組成物
WO2019189545A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 細胞の製造方法
US11268070B2 (en) 2018-04-16 2022-03-08 Cellular Engineering Technologies, Inc. Methods for creating integration-free, virus-free, exogenous oncogene-free IPS cells and compositions for use in such methods
AU2019256723A1 (en) 2018-04-20 2020-11-05 FUJIFILM Cellular Dynamics, Inc. Method for differentiation of ocular cells and use thereof
AU2019261083A1 (en) 2018-04-23 2020-11-12 Orizuru Therapeutics, Inc. Growth inhibitor
JP7311116B2 (ja) 2018-04-27 2023-07-19 株式会社カネカ 膵臓β細胞の製造方法
US20210254006A1 (en) 2018-06-06 2021-08-19 Ideaya Biosciences, Inc. Methods of culturing and/or expanding stem cells and/or lineage committed progenitor cells using lactam compounds
EP3806861A1 (en) 2018-06-18 2021-04-21 University of Rochester Methods of treating schizophrenia and other neuropsychiatric disorders
EP3810184A2 (en) 2018-06-21 2021-04-28 University of Rochester Methods of treating or inhibiting onset of huntington's disease
SG11202100260QA (en) 2018-07-13 2021-02-25 Univ Kyoto METHOD FOR PRODUCING γδ T CELLS
JP7285015B2 (ja) 2018-07-19 2023-06-01 国立大学法人京都大学 多能性幹細胞由来の板状軟骨およびその製造方法
WO2020022261A1 (ja) 2018-07-23 2020-01-30 国立大学法人京都大学 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法
CA3108679A1 (en) 2018-08-03 2020-02-06 Kyoto University Cell production method
CN112567025A (zh) 2018-08-10 2021-03-26 国立大学法人京都大学 Cd3阳性细胞的制造方法
AU2019320072A1 (en) 2018-08-10 2021-02-25 Vertex Pharmaceuticals Incorporated Stem cell derived islet differentiation
TW202035697A (zh) 2018-08-10 2020-10-01 國立大學法人京都大學 使用陽離子性脂質對心肌細胞進行轉染的方法
US20210177909A1 (en) 2018-08-14 2021-06-17 National Center For Global Health And Medicine Supernatant of brown adipocytes, method for preparing same and utilization thereof
EP3842513A4 (en) 2018-08-20 2022-06-29 I Peace, Inc. Cell incubator
US20210198635A1 (en) 2018-08-20 2021-07-01 I Peace, Inc. Cell culture or induction method
US20210198624A1 (en) 2018-08-22 2021-07-01 Kyoto University Method for producing enteric neural precursors
EP3845654A4 (en) 2018-08-31 2022-05-11 Noile-Immune Biotech, Inc. CAR-EXPRESSING T CELLS AND CAR-EXPRESSION VECTOR
JP7295576B2 (ja) 2018-09-19 2023-06-21 オリヅルセラピューティクス株式会社 インスリン産生細胞
EP3800246A4 (en) 2018-10-10 2022-04-20 National University Corporation Tottori University METHOD FOR THE PRODUCTION OF HUMAN INDUCED PLURIPOTENT STEM CELLS CONTAINING AN EXOGENOUS CHROMOSOME
WO2020075823A1 (ja) 2018-10-10 2020-04-16 国立大学法人鳥取大学 微小核細胞融合法による目的ｄｎａを含む動物細胞の作製方法
US20210292791A1 (en) 2018-10-12 2021-09-23 Vivet Therapeutics Codon-optimized transgene for the treatment of progressive familiar intrahepatic cholestasis type 3 (pfic3)
JPWO2020080270A1 (ja) 2018-10-15 2021-09-16 公立大学法人横浜市立大学 栄養組成物
WO2020090903A1 (ja) 2018-10-31 2020-05-07 国立大学法人京都大学 中内胚葉系への分化抵抗性が解除された多能性幹細胞の作製方法
BR112021008434A2 (pt) 2018-11-07 2021-09-28 Vivet Therapeutics Transgene abcb11 otimizado por códon para o tratamento de colestase intra-hepática familiar progressiva tipo 2 (pfic2)
US20210369870A1 (en) 2018-11-16 2021-12-02 Encoded Therapeutics, Inc. Compositions and methods for treating wilson's disease
JP2022513073A (ja) 2018-11-19 2022-02-07 ザ ユナイテッド ステイツ オブ アメリカ アズ リプリゼンテッド バイ ザ セクレタリー、デパートメント オブ ヘルス アンド ヒューマン サービシーズ 生分解性組織置換インプラントおよびその使用
KR20210096638A (ko) 2018-11-28 2021-08-05 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 억제성 환경에 대한 기능 및 내성을 증진시키기 위한 면역 세포의 멀티플렉스 게놈 편집
US20220017867A1 (en) 2018-12-06 2022-01-20 Kirin Holdings Kabushiki Kaisha Production method for t cells or nk cells, medium for culturing t cells or nk cells, method for culturing t cells or nk cells, method for maintaining undifferentiated state of undifferentiated t cells, and growth-accelerating agent for t cells or nk cells
AU2019396450A1 (en) 2018-12-11 2021-06-24 University Of Rochester Methods of treating schizophrenia and other neuropsychiatric disorders
EP3900787A4 (en) 2018-12-21 2022-02-23 Kyoto University CARTILAGE-LIKE TISSUE WITH LOCALIZED LUBRICINE, METHOD FOR THE PRODUCTION THEREOF, AND COMPOSITION COMPRISING IT FOR THE TREATMENT OF ARTICULAR CARTILAGE LESIONS
WO2020138371A1 (ja) 2018-12-26 2020-07-02 キリンホールディングス株式会社 改変ｔｃｒ及びその製造方法
KR20210109000A (ko) 2018-12-27 2021-09-03 고쿠리츠 다이가쿠 호진 교토 다이가쿠 T-세포 수용체 개변체
WO2020158914A1 (ja) 2019-02-01 2020-08-06 国立大学法人京都大学 細胞の検出方法
EP3923962A2 (en) 2019-02-13 2021-12-22 University of Rochester Gene networks that mediate remyelination of the human brain
JPWO2020175592A1 (ja) 2019-02-26 2020-09-03
JP2020141588A (ja) 2019-03-05 2020-09-10 ファナック株式会社 細胞製造システム
WO2020181101A1 (en) 2019-03-07 2020-09-10 The Regents Of The University Of California Crispr-cas effector polypeptides and methods of use thereof
WO2020209959A1 (en) 2019-03-08 2020-10-15 Crispr Therapeutics Ag Nucleobase-editing fusion protein systems, compositions, and uses thereof
EP3937963A2 (en) 2019-03-12 2022-01-19 CRISPR Therapeutics AG Novel high fidelity rna-programmable endonuclease systems and uses thereof
WO2020203538A1 (ja) 2019-03-29 2020-10-08 株式会社カネカ 多能性幹細胞を含む細胞集団及びその製造方法
EP3950953A4 (en) 2019-03-29 2023-04-19 Public University Corporation Yokohama City University SCREENING PROCEDURES AND TOXICITY ASSESSMENT PROCEDURES
KR20210151903A (ko) 2019-04-10 2021-12-14 오리즈루 세라퓨틱스 가부시키가이샤 생체 조직형 구조체의 제조 방법
EP3957722A4 (en) 2019-04-17 2023-01-18 Keio University PRODUCTION PROCEDURE AND KIT OF INDUCED PLURIPOTENTS STEM CELLS
US20210047649A1 (en) 2019-05-08 2021-02-18 Vertex Pharmaceuticals Incorporated Crispr/cas all-in-two vector systems for treatment of dmd
CN113811316A (zh) 2019-05-15 2021-12-17 味之素株式会社 神经嵴细胞或角膜上皮细胞的纯化方法
CA3141455A1 (en) 2019-05-20 2020-11-26 Ajinomoto Co., Inc. Expansion culture method for cartilage or bone precursor cells
CN113785049A (zh) 2019-06-10 2021-12-10 爱平世股份有限公司 红细胞除去装置、单核细胞回收器、细胞培养装置、细胞培养系统、细胞培养方法及单核细胞的回收方法
CN113874488A (zh) 2019-06-10 2021-12-31 爱平世股份有限公司 红细胞除去装置、单核细胞回收器、细胞培养装置、细胞培养系统、细胞培养方法及单核细胞的回收方法
EP3985104A4 (en) 2019-06-11 2023-04-12 Kyoto University PROCEDURE FOR GENERATING A KIDNEY INTERSTITIAL CELL
EP3990624A1 (en) 2019-06-25 2022-05-04 Vertex Pharmaceuticals Incorporated Enhanced differentiation of beta cells
US20220234043A1 (en) 2019-06-28 2022-07-28 I Peace, Inc. Cell mass dissociator, method for manufacturing cell mass dissociator, and method for dissociating cell mass
EP3992277A4 (en) 2019-06-28 2023-10-04 I Peace, Inc. CELL CULTURE CONTAINER AND CELL CULTURE APPARATUS
JP7344421B2 (ja) 2019-07-19 2023-09-14 東京エレクトロン株式会社 細胞の分化状態の評価方法
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
WO2021030424A1 (en) 2019-08-13 2021-02-18 Semma Therapeutics, Inc. Pancreatic differentiation
WO2021033699A1 (ja) 2019-08-20 2021-02-25 国立大学法人京都大学 心筋細胞の富化方法
US20230038829A1 (en) 2019-08-29 2023-02-09 Fanuc Corporation Cell production device and cell production method
WO2021038998A1 (ja) 2019-08-29 2021-03-04 ファナック株式会社 細胞製造装置及びそのシステム
CN114341337A (zh) 2019-08-29 2022-04-12 发那科株式会社 细胞制造装置
EP4043553A4 (en) 2019-10-01 2023-11-22 Kyoto University METHOD FOR ISOLATING URETERAL NODLE CELLS
JPWO2021079874A1 (ja) 2019-10-21 2021-04-29
EP4052718A1 (en) 2019-10-31 2022-09-07 Life Science Institute, Inc. Therapy for interstitial cystitis by pluripotent stem cells
CN114729318A (zh) 2019-11-01 2022-07-08 国立大学法人京都大学 T细胞的制备方法
WO2021090767A1 (ja) 2019-11-06 2021-05-14 アイ ピース， インコーポレイテッド 細胞培養装置
JPWO2021095811A1 (ja) 2019-11-12 2021-05-20
BR112022009181A2 (pt) 2019-11-25 2022-07-26 Univ Kyoto Sistema para prover um produto de célula t, métodos para produzir um produto de célula t, para construir um banco celular e uma coleção de produto de célula t e para prover um produto de célula t, banco celular, coleções de banco celular e de produto de célula t, e, produto de célula t
JP7058431B2 (ja) 2019-12-12 2022-04-22 国立大学法人千葉大学 巨核球および血小板を含む凍結乾燥製剤
FR3105260A1 (fr) 2019-12-20 2021-06-25 Centre National De La Recherche Scientifique (Cnrs) Modèle organoïde cardiaque vascularisé apres incorporation de cardiomyocytes dérivés de cellules souches pluripotentes induites humaines
CN115427555A (zh) 2020-02-28 2022-12-02 武田药品工业株式会社 由多能干细胞产生自然杀伤细胞的方法
JP2023516484A (ja) 2020-03-11 2023-04-19 ビット バイオ リミテッド 肝細胞作製方法
JP2023517112A (ja) 2020-03-13 2023-04-21 ゴーリヴァー・セラピューティクス 劇症肝障害を処置及び／又は防止するための肝幹細胞様細胞
EP4123010A4 (en) 2020-03-18 2024-03-27 Fanuc Corporation MICROSCOPE OBSERVATION SYSTEM
BR112022018640A2 (pt) 2020-03-19 2022-11-08 Orizuru Therapeutics Inc Métodos para produzir uma população de células compreendendo cardiomiócitos e para purificar cardiomiócitos, população de células contendo cardiomiócitos, e, agente para terapia de transplante de células
WO2021187602A1 (ja) 2020-03-19 2021-09-23 国立大学法人京都大学 心筋細胞の精製方法
JPWO2021193360A1 (ja) 2020-03-24 2021-09-30
EP4129339A1 (en) 2020-03-31 2023-02-08 Sky Pharma Co., Ltd. Method for screening for, method for producing, and method for designing drug active ingredients
US20230159891A1 (en) 2020-03-31 2023-05-25 Kyoto University T cell progenitor production method
CA3185067A1 (en) 2020-05-26 2021-12-02 Kouichi Tamura Hypoimmunogenic cells
EP4159838A4 (en) 2020-05-28 2024-07-17 Orizuru Therapeutics Inc METHOD FOR MASS PRODUCTION OF CELL AGGREGATE OF UNIFORM SIZE
AU2021280332A1 (en) 2020-05-29 2022-12-01 FUJIFILM Cellular Dynamics, Inc. Bilayer of retinal pigmented epithelium and photoreceptors and use thereof
IL298085A (en) 2020-05-29 2023-01-01 Fujifilm Cellular Dynamics Inc Retinal pigment epithelium and bicellular photoreceptor aggregates and methods of using them
US20230235319A1 (en) 2020-06-12 2023-07-27 Bayer Aktiengesellschaft Crispr-cas12a directed random mutagenesis agents and methods
JPWO2021256522A1 (ja) 2020-06-17 2021-12-23
JP7429294B2 (ja) 2020-07-13 2024-02-07 国立大学法人京都大学 骨格筋前駆細胞及びその精製方法、筋原性疾患を治療するための組成物、並びに骨格筋前駆細胞を含む細胞群の製造方法
EP4180514A1 (en) 2020-07-20 2023-05-17 Aichi Medical University Composition for undifferentiated maintenance culture of pluripotent cells, medium for undifferentiated maintenance culture of pluripotent cells, maintenance culture method in undifferentiated state of pluripotent cells, and method for producing pluripotent cells
US20230265456A1 (en) 2020-08-10 2023-08-24 Fundacion Para La Investigacion Medica Aplicada Gene therapy vector expressing cyp27a1 for the treatment of cerebrotendinous xanthomatosis
JPWO2022039279A1 (ja) 2020-08-18 2022-02-24
CN116018402A (zh) 2020-09-04 2023-04-25 心脏康复株式会社 iPS细胞的品质改善剂、iPS细胞的制备方法、iPS细胞、及iPS细胞制备用组合物
WO2022069598A1 (en) 2020-09-29 2022-04-07 Genethon Enhancing utrophin expression in cell by inducing mutations within utrophin regulatory elements and therapeutic use thereof
WO2022104109A1 (en) 2020-11-13 2022-05-19 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
TW202237818A (zh) 2020-11-20 2022-10-01 日商千紙鶴治療公司 成熟化劑
EP4251645A1 (en) 2020-11-25 2023-10-04 Catamaran Bio, Inc. Cellular therapeutics engineered with signal modulators and methods of use thereof
EP4263818A1 (en) 2020-12-16 2023-10-25 Universitat Pompeu Fabra Therapeutic lama2 payload for treatment of congenital muscular dystrophy
JP2022099262A (ja) 2020-12-22 2022-07-04 アイ ピース，インコーポレイテッド 細胞の培養器及び細胞の培養方法
CN116583595A (zh) 2020-12-23 2023-08-11 三井化学株式会社 培养构件及其用途
WO2022136616A1 (en) 2020-12-23 2022-06-30 Vivet Therapeutics Minimal bile acid inducible promoters for gene therapy
US20240060051A1 (en) 2020-12-25 2024-02-22 Kyoto University Method for Producing Naive Human IPS Cells From Somatic Cells
JPWO2022163466A1 (ja) * 2021-01-26 2022-08-04
CN116829697A (zh) 2021-02-09 2023-09-29 千纸鹤治疗公司 促熟剂
EP4306633A1 (en) 2021-03-09 2024-01-17 National University Corporation Tokyo Medical and Dental University Cell cluster production method
EP4310176A1 (en) 2021-03-17 2024-01-24 Astellas Pharma Inc. Pericyte having basic fibroblast growth factor (bfgf) gene introduced therein
EP4060026A1 (en) 2021-03-19 2022-09-21 Technische Universität Dresden Ex-vivo proliferation of human phagocytic cells
AU2022240974A1 (en) 2021-03-19 2023-09-07 Centre National De La Recherche Scientifique (Cnrs) Human macrophages resistant to tumor-induced repolarization
EP4134086A1 (en) 2021-08-12 2023-02-15 Technische Universität Dresden Human macrophages resistant to tumor-induced repolarization
WO2022207889A1 (en) 2021-04-01 2022-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Liver organoid manufacturing methods, liver organoids obtained with the same, and uses thereof
AR125306A1 (es) 2021-04-08 2023-07-05 Takeda Pharmaceuticals Co Método para la activación de las células t
JPWO2022230919A1 (ja) 2021-04-28 2022-11-03
EP4331673A1 (en) 2021-04-30 2024-03-06 Riken Cord-like aggregates of retinal pigment epithelial cells, device and production method for producing same, and therapeutic agent comprising said cord-like aggregates
WO2022236187A1 (en) 2021-05-07 2022-11-10 Children's Hospital Los Angeles Methods for making stem cell-derived enteric neural crest cells and their use in enteric neuropathy treatment
EP4347796A1 (en) 2021-05-26 2024-04-10 Fujifilm Cellular Dynamics, Inc. Methods to prevent rapid silencing of genes in pluripotent stem cells
WO2022251477A1 (en) 2021-05-28 2022-12-01 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Biodegradable tissue scaffold with secondary matrix to host weakly adherent cells
AU2022280062A1 (en) 2021-05-28 2023-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Methods to generate macular, central and peripheral retinal pigment epithelial cells
EP4352205A1 (en) 2021-06-07 2024-04-17 Institut National de la Santé et de la Recherche Médicale (INSERM) Method for generating highly functional hepatocytes by differentiating hepatoblasts
CA3222761A1 (en) 2021-06-10 2022-12-15 Ajinomoto Co., Inc. Method for producing mesenchymal stem cells
AU2022290382A1 (en) 2021-06-11 2023-11-23 Bayer Aktiengesellschaft Type v rna programmable endonuclease systems
EP4101928A1 (en) 2021-06-11 2022-12-14 Bayer AG Type v rna programmable endonuclease systems
TW202317755A (zh) 2021-06-15 2023-05-01 日商武田藥品工業股份有限公司 用於自多能幹細胞產生自然殺手細胞之方法
JPWO2023277195A1 (ja) 2021-06-29 2023-01-05
EP4372079A1 (en) 2021-07-15 2024-05-22 Astellas Pharma Inc. Pericyte-like cells expressing vascular endothelial growth factor (vegf) at high level
EP4372080A1 (en) 2021-07-15 2024-05-22 Astellas Pharma Inc. Pericyte-like cell expressing vascular endothelial growth factor (vegf) at high level
JPWO2023003025A1 (ja) 2021-07-21 2023-01-26
WO2023017848A1 (ja) 2021-08-11 2023-02-16 国立大学法人京都大学 腎間質前駆細胞の製造方法並びにエリスロポエチン産生細胞、およびレニン産生細胞の製造方法
EP4144841A1 (en) 2021-09-07 2023-03-08 Bayer AG Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof
AU2022343749A1 (en) 2021-09-13 2024-03-28 FUJIFILM Cellular Dynamics, Inc. Methods for the production of committed cardiac progenitor cells
AU2022349176A1 (en) 2021-09-27 2024-04-11 Kyoto University Method for producing t cell
WO2023053220A1 (ja) 2021-09-28 2023-04-06 公益財団法人京都大学ｉＰＳ細胞研究財団 多能性幹細胞の製造方法
WO2023069979A1 (en) 2021-10-20 2023-04-27 University Of Rochester Isolated glial progenitor cells for use in the competition treatment of age-related white matter loss
US20230292719A1 (en) 2021-10-20 2023-09-21 University Of Rochester Humanized chimeras for the prospective assessment of cell addition and replacement therapies
CA3233935A1 (en) 2021-10-20 2023-04-27 University Of Rochester Method for rejuvenating glial progenitor cells and rejuvenated glial progenitor cells per se
WO2023070019A1 (en) 2021-10-21 2023-04-27 Vertex Pharmaceuticals Incorporated Hypoimmune cells
US11992506B2 (en) 2021-11-01 2024-05-28 Vertex Pharmaceuticals Incorporated Stem cell derived pancreatic islet differentiation
WO2023081633A1 (en) 2021-11-02 2023-05-11 University Of Rochester Tcf7l2 mediated remyelination in the brain
WO2023085356A1 (ja) 2021-11-11 2023-05-19 株式会社ヘリオス 遺伝子改変多能性幹細胞、それ由来の免疫担当細胞、それらの製造方法及びそれらの用途
WO2023085433A1 (ja) 2021-11-15 2023-05-19 国立大学法人鳥取大学 ヒト細胞内でヒト人工染色体ベクターを作製する方法
KR20240099271A (ko) 2021-11-16 2024-06-28 각코 호진 도쿄 약카 다이가쿠 프로모터 활성화 서열, 그 프로모터 활성화 서열을 포함하는 발현 벡터, 및 그 발현 벡터를 포함하는 포유 동물 세포
JPWO2023090361A1 (ja) 2021-11-16 2023-05-25
WO2023118068A1 (en) 2021-12-23 2023-06-29 Bayer Aktiengesellschaft Novel small type v rna programmable endonuclease systems
WO2023150557A1 (en) 2022-02-01 2023-08-10 University Of Rochester Methods of generating a population of neurons from human glial progenitor cells and genetic constructs for carrying out such methods
WO2023167986A1 (en) 2022-03-02 2023-09-07 Lineage Cell Therapeutics, Inc. Methods and compositions for treating hearing loss
WO2023172514A1 (en) 2022-03-07 2023-09-14 Catamaran Bio, Inc. Engineered immune cell therapeutics targeted to her2 and methods of use thereof
WO2023211857A1 (en) 2022-04-25 2023-11-02 Lineage Cell Therapeutics, Inc. Methods and compositions for treating vision loss
WO2023215455A1 (en) 2022-05-05 2023-11-09 University Of Rochester Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease
WO2023237587A1 (en) 2022-06-10 2023-12-14 Bayer Aktiengesellschaft Novel small type v rna programmable endonuclease systems
WO2023247532A1 (en) 2022-06-21 2023-12-28 Institut National de la Santé et de la Recherche Médicale A method for producing a bioengineered mammal induced pluripotent stem cell-derived cardiac organoid
US20240003871A1 (en) 2022-06-29 2024-01-04 FUJIFILM Cellular Dynamics, Inc. Ipsc-derived astrocytes and methods of use thereof
EP4338745A1 (en) 2022-09-14 2024-03-20 Technische Universität Dresden Allogeneic human macrophages for cell therapy
US20240139256A1 (en) 2022-09-30 2024-05-02 FUJIFILM Cellular Dynamics, Inc. Methods for the production of cardiac fibroblasts
WO2024129743A2 (en) 2022-12-13 2024-06-20 Bluerock Therapeutics Lp Engineered type v rna programmable endonucleases and their uses

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US70292A (en) * 1867-10-29 Petess
US4650761A (en) * 1981-11-27 1987-03-17 Eli Lilly And Company Method for stabilizing and selecting recombinant DNA containing host cell
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4861719A (en) * 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US4937190A (en) * 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US6140111A (en) * 1987-12-11 2000-10-31 Whitehead Institute For Biomedical Research Retroviral gene therapy vectors and therapeutic methods based thereon
US5591624A (en) * 1988-03-21 1997-01-07 Chiron Viagene, Inc. Retroviral packaging cell lines
US7070994B2 (en) * 1988-03-21 2006-07-04 Oxford Biomedica (Uk) Ltd. Packaging cells
JP2886547B2 (ja) 1988-07-26 1999-04-26 協和醗酵工業株式会社 ノイラミニダーゼの製造法
JP3082204B2 (ja) * 1988-09-01 2000-08-28 ホワイトヘッド・インスティチュート・フォー・バイオメディカル・リサーチ 両栄養性および環境栄養性宿主域を持つ組換え体レトロウイルス
US5266491A (en) * 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
JP3051411B2 (ja) * 1989-03-14 2000-06-12 持田製薬株式会社 新規ｄｎａならびにそれを含有する発現プラスミド
JP2897295B2 (ja) * 1989-12-14 1999-05-31 味の素株式会社 レトロウィルス高生産用ｄｎａ構築物及びレトロウィルス高生産用細胞株
US5670617A (en) * 1989-12-21 1997-09-23 Biogen Inc Nucleic acid conjugates of tat-derived transport polypeptides
US5817491A (en) * 1990-09-21 1998-10-06 The Regents Of The University Of California VSV G pseusdotyped retroviral vectors
US5288514A (en) * 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5834256A (en) * 1993-06-11 1998-11-10 Cell Genesys, Inc. Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells
FR2707091B1 (fr) 1993-06-30 1997-04-04 Cohen Haguenauer Odile Vecteur rétroviral pour le transfert et l'expression de gènes dans des cellules eucaryotes.
US5534423A (en) 1993-10-08 1996-07-09 Regents Of The University Of Michigan Methods of increasing rates of infection by directing motion of vectors
US5519134A (en) * 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US6013517A (en) * 1994-05-09 2000-01-11 Chiron Corporation Crossless retroviral vectors
US5525735A (en) * 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) * 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
PT787200E (pt) * 1994-10-28 2005-08-31 Univ Pennsylvania Adenovirus melhorado e metodos para a sua utilizacao
US5843780A (en) * 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5637456A (en) * 1995-02-17 1997-06-10 The University Of Texas, Board Of Regents Rapid test for determining the amount of functionally inactive gene in a gene therapy vector preparation
US5707618A (en) * 1995-03-24 1998-01-13 Genzyme Corporation Adenovirus vectors for gene therapy
US5830725A (en) * 1995-04-28 1998-11-03 The Board Of Trustees For The Leland Stanford Junior University Rapid, stable high-titre production of recombing retrovirus
US5744320A (en) * 1995-06-07 1998-04-28 Promega Corporation Quenching reagents and assays for enzyme-mediated luminescence
CA2227786A1 (en) * 1995-07-28 1997-02-13 Marie Curie Cancer Care Transport proteins and their uses
JP4053595B2 (ja) * 1995-09-22 2008-02-27 メディカル・リサーチ・カウンシル 核酸の突然変異誘発におけるまたはそれに関する改良
US5910434A (en) * 1995-12-15 1999-06-08 Systemix, Inc. Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant
FR2751345B1 (fr) * 1996-07-16 1998-09-18 Univ Paris Curie Lignees d'encapsidation hautement productrices
US6255071B1 (en) * 1996-09-20 2001-07-03 Cold Spring Harbor Laboratory Mammalian viral vectors and their uses
US6025192A (en) * 1996-09-20 2000-02-15 Cold Spring Harbor Laboratory Modified retroviral vectors
US6017735A (en) * 1997-01-23 2000-01-25 Marie Curie Cancer Care Materials and methods for intracellular transport and their uses
US6416959B1 (en) * 1997-02-27 2002-07-09 Kenneth Giuliano System for cell-based screening
AU9200398A (en) * 1997-08-22 1999-03-16 Yale University A process to study changes in gene expression in granulocytic cells
JPH11115328A (ja) * 1997-10-16 1999-04-27 Dainippon Printing Co Ltd 熱転写受像シート及びその製造方法
US6835567B1 (en) * 1998-04-14 2004-12-28 Signal Pharmaceuticals, Inc. PNS cell lines and methods of use therefor
US20020174013A1 (en) 1998-04-17 2002-11-21 Viztec Inc., A Florida Corporation Chip card advertising method and system
US6146874A (en) * 1998-05-27 2000-11-14 University Of Florida Method of preparing recombinant adeno-associated virus compositions
KR20000006334A (ko) * 1998-06-26 2000-01-25 이선경 바이러스코딩염기서열이전혀없는고효율레트로바이러스벡터
US6485959B1 (en) 1998-10-07 2002-11-26 Cedars Sinai Medical Center Cell preconditioning and cryopresevation medium
AU6339399A (en) 1998-10-16 2000-05-08 Novartis Ag Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
WO2000027995A1 (en) 1998-11-09 2000-05-18 Monash University Embryonic stem cells
US6376246B1 (en) * 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6153432A (en) * 1999-01-29 2000-11-28 Zen-Bio, Inc Methods for the differentiation of human preadipocytes into adipocytes
US6312949B1 (en) 1999-03-26 2001-11-06 The Salk Institute For Biological Studies Regulation of tyrosine hydroxylase expression
US6773920B1 (en) * 1999-03-31 2004-08-10 Invitrogen Corporation Delivery of functional protein sequences by translocating polypeptides
EP1186655B1 (en) * 1999-06-01 2008-04-09 Chugai Seiyaku Kabushiki Kaisha Packaging cell
US7015037B1 (en) * 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
AU7473500A (en) * 1999-09-01 2001-03-26 University Of Pittsburgh Identification of peptides that facilitate uptake and cytoplasmic and/or nucleartransport of proteins, dna and viruses
US20030161817A1 (en) * 2001-03-28 2003-08-28 Young Henry E. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
WO2001021767A2 (en) 1999-09-24 2001-03-29 Morphogen Pharmaceuticals, Inc. Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
US6280718B1 (en) 1999-11-08 2001-08-28 Wisconsin Alumni Reasearch Foundation Hematopoietic differentiation of human pluripotent embryonic stem cells
US7544509B2 (en) * 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
US6395546B1 (en) 2000-02-01 2002-05-28 Neurogeneration, Inc. Generation of dopaminergic neurons from human nervous system stem cells
US7439064B2 (en) * 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
WO2001088104A2 (en) 2000-05-17 2001-11-22 Geron Corporation Neural progenitor cell populations
AU6842001A (en) * 2000-06-15 2001-12-24 Tanja Dominko Pluripotent mammalian cells
DE10031179A1 (de) 2000-06-27 2002-01-31 Amaxa Gmbh Verfahren zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms
US6841535B2 (en) * 2000-07-31 2005-01-11 Active Motif Peptide-mediated transfection agents and methods of use
JP2002065261A (ja) 2000-08-30 2002-03-05 Mitsubishi Kasei Institute Of Life Sciences 生殖細胞の取得方法
AU2001289852A1 (en) * 2000-08-31 2002-03-13 Edwin Lundgren Control device for a steering kite on a boat
US20020127715A1 (en) 2000-11-27 2002-09-12 Nissim Benvenisty Transfection of human embryonic stem cells
US20080268054A1 (en) 2000-12-04 2008-10-30 Eugene Bell Dermal derived human stem cells and compositions and methods thereof
RU2338544C2 (ru) 2001-01-02 2008-11-20 Стемрон Инк. Способ получения популяции гомозиготных стволовых клеток с предварительно отобранным иммунотипом и/или генотипом, клетки, подходящие для получения из них трансплантата, и материалы и способы их получения
WO2002061052A2 (en) * 2001-01-31 2002-08-08 Interface Biotech A/S An improved in vitro method of culturing mammalian cells for autologous cell implantation/transplantation methods
JP2003009854A (ja) 2001-04-09 2003-01-14 Kyowa Hakko Kogyo Co Ltd エンブリオイドボディ形成方法及びその用途
DE10119901A1 (de) 2001-04-23 2002-10-24 Amaxa Gmbh Schaltungsanordnung zur Einbringung von Nukleinsäuren und anderen biologisch aktiven Molekülen in den Kern höherer eukaryontischer Zellen mit Hilfe elektrischen Stroms
CN1302115C (zh) 2001-04-23 2007-02-28 埃麦克萨有限公司 电穿孔用缓冲溶液及上述溶液的使用方法
JP4183614B2 (ja) * 2001-05-31 2008-11-19 伸弥 山中 Ｅｓ細胞特異的発現遺伝子
US20030044976A1 (en) 2001-08-27 2003-03-06 Advanced Cell Technology De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
EP1437406A4 (en) * 2001-09-20 2004-12-15 Kyowa Hakko Kogyo Kk TOTIPOTENT STEM CELLS FROM SKELETAL MUSCLE INTESTINAL TISSUES
JP2004248505A (ja) * 2001-09-21 2004-09-09 Norio Nakatsuji 移植抗原の一部または全てを欠除したｅｓ細胞由来の未分化な体細胞融合細胞およびその製造
CA2461185A1 (en) 2001-09-21 2003-04-03 Japan Science And Technology Corporation Method of screening reprogramming factor, reprogramming factor screened by the method, method of using the reprogramming factor, method of differentiating undifferentiated fused cells and method of constructing cell, tissues and organs
US7588937B2 (en) * 2001-10-03 2009-09-15 Wisconsin Alumni Research Foundation Method of in vitro differentiation of neural stem cells, motor neurons and dopamine neurons from primate embryonic stem cells
DE10162080A1 (de) * 2001-12-10 2003-06-26 Albrecht Mueller Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential
WO2003055989A2 (en) * 2001-12-21 2003-07-10 Mount Sinai Hospital Cellular compositions and methods of making and using them
AU2003238620B2 (en) * 2002-01-31 2008-11-06 Asahi Techno Glass Corporation Liquid for frozen storage of primate embryo stem cells and frozen storage method
EP1482787A4 (en) * 2002-02-13 2006-02-15 Anthrogenesis Corp EMBRYONIC TYPE DERIVED STEM CELLS DERIVED FROM MAMMALIAN POST-PARTUM PLACENTA, USES THEREOF, AND METHODS OF TREATMENT BASED ON CELLS OF THIS TYPE
ES2198216B1 (es) * 2002-07-02 2005-04-16 Juan Carlos Instituto Cientifico Y Tecnologico De Navarra, S.A.(67%). Medio de cultivo de celulas madre-progenitoras autologas humanas y sus aplicaciones.
US7422736B2 (en) 2002-07-26 2008-09-09 Food Industry Research And Development Institute Somatic pluripotent cells
US20040048297A1 (en) * 2002-07-30 2004-03-11 Gene Logic, Inc. Nucleic acid detection assay control genes
JP3736517B2 (ja) 2002-11-13 2006-01-18 学校法人近畿大学 体細胞核初期化因子
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
EP1619242A4 (en) * 2003-03-25 2006-09-06 Japan Science & Tech Agency CONTROL OF INDUCTION OF DIFFERENTIATION OF STEM CELLS AND DIFFERENTIATION CAPACITY
CN1536076A (zh) * 2003-04-09 2004-10-13 中国人民解放军军事医学科学院野战输 成年人骨髓间充质干细胞体外扩增和定向诱导分化为心肌样细胞的方法
US9567591B2 (en) 2003-05-15 2017-02-14 Mello Biotechnology, Inc. Generation of human embryonic stem-like cells using intronic RNA
JPWO2004101775A1 (ja) * 2003-05-16 2006-07-13 協和醗酵工業株式会社 新規な成体組織由来の幹細胞およびその用途
WO2005010524A1 (en) * 2003-06-04 2005-02-03 Curis, Inc. Stem cell-based methods for identifying and characterizing agents
FR2859219B1 (fr) * 2003-09-02 2005-10-14 Alain Privat Procede de production de neurones a partir de cellules d'une lignee cellulaire
JP2005095027A (ja) 2003-09-22 2005-04-14 Reprocell Inc 細胞の未分化状態マーカープロモーターおよびその利用
JPWO2005035741A1 (ja) 2003-10-09 2006-12-21 協和醗酵工業株式会社 ゲノムが改変された細胞
JP4976852B2 (ja) 2003-11-10 2012-07-18 ザ スクリプス リサーチ インスティチュート 細胞脱分化を誘導するための組成物および方法
US7682828B2 (en) * 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
CA2549158A1 (en) 2003-12-01 2005-06-16 Technion Research And Development Foundation Ltd. Methods of generating stem cells and embryonic bodies carrying disease-causing mutations and methods of using same for studying genetic disorders
WO2005065354A2 (en) * 2003-12-31 2005-07-21 The Burnham Institute Defined media for pluripotent stem cell culture
US7964401B2 (en) 2004-02-19 2011-06-21 Kyoto University Screening method for somatic cell nuclear reprogramming substance affecting ECAT2 and ECAT3
BRPI0509179A (pt) 2004-03-23 2007-09-18 Daiichi Asubio Pharma Co Ltd método de crescimento de célula tronco pluripotente
JP4314372B2 (ja) * 2004-03-30 2009-08-12 国立大学法人京都大学 精巣細胞由来多能性幹細胞の製造方法
WO2005117557A2 (en) * 2004-06-01 2005-12-15 San Diego State University Foundation Expression system
WO2006006692A1 (ja) * 2004-07-08 2006-01-19 Japan Science And Technology Agency 低血清培養で選択的に増殖する動物組織遍在性の分化多能性細胞
WO2006084229A2 (en) 2004-07-15 2006-08-10 Primegen Biotech, Llc Use of nuclear material to therapeutically reprogram differentiated cells
WO2006017476A2 (en) * 2004-08-02 2006-02-16 The Research Foundation Of State University Of New York Amino functionalized ormosil nanoparticles as delivery vehicles
US7803920B2 (en) 2004-09-29 2010-09-28 Shinya Yamanaka ECAT16 gene expressed specifically in ES cells and utilization of the same
US20060095319A1 (en) * 2004-10-29 2006-05-04 Cardwell Carlzo B Marketing and compensation method
WO2006088867A2 (en) 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
WO2006093172A1 (ja) * 2005-02-28 2006-09-08 Foundation For Biomedical Research And Innovation 成体幹細胞の体外増幅方法
US20070033061A1 (en) * 2005-04-05 2007-02-08 Achaogen, Inc. Business methods for commercializing antimicrobial and cytotoxic compounds
WO2007026255A2 (en) 2005-06-22 2007-03-08 Universitetet I Oslo Dedifferentiated cells and methods of making and using dedifferentiated cells
JP4395193B2 (ja) * 2005-08-01 2010-01-06 ニューポテンシャル，インコーポレイテッド 回復能を有する再プログラムされた細胞の作製
AU2006313518A1 (en) 2005-11-11 2007-05-18 The University Court Of University Of Edinburgh Reprogramming and genetic modification of cells
US20090227032A1 (en) * 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8129187B2 (en) * 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
MX2008007654A (es) 2005-12-13 2008-09-26 Univ Kyoto Factor de reprogramacion nuclear.
US8278104B2 (en) * 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
CN101389761A (zh) 2006-02-27 2009-03-18 银怎株式会社 使用bmi-1使星形胶质细胞去分化成为神经干细胞
US20090252711A1 (en) 2006-05-11 2009-10-08 Andrew Craig Boquest Stem Cells And Methods Of Making And Using Stem Cells
WO2008030610A2 (en) 2006-09-08 2008-03-13 Michigan State University Human transcriptome corresponding to human oocytes and use of said genes or the corresponding polypeptides to trans-differentiate somatic cells
JP2008099662A (ja) 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research 幹細胞の培養方法
US20080132803A1 (en) * 2006-11-30 2008-06-05 Hyman Friedlander Method and system for doing business by mining the placental-chord complex
JP5419279B2 (ja) 2007-01-17 2014-02-19 ウィスコンシン アラムニ リサーチ ファンデーション 改良された幹細胞の培養
EP2132225A4 (en) 2007-02-27 2010-06-09 Procell Therapeutics Inc COMBINED USE OF NANOG AND OCT4 PERMEABLE TO CELLS TO INCREASE SELF-RENEWAL AND DELETE DIFFERENTIATION OF STEM CELLS
WO2008105566A1 (en) 2007-02-27 2008-09-04 Korea Stem Cell Bank System for providing stem cell services using internet and method thereof
JP5813321B2 (ja) 2007-03-23 2015-11-17 ウィスコンシン アラムニ リサーチ ファンデーション 体細胞の再プログラム化
AU2008236629B2 (en) 2007-04-07 2014-03-06 Whitehead Institute For Biomedical Research Reprogramming of somatic cells
WO2008150814A2 (en) 2007-05-29 2008-12-11 Reid Christopher B Methods for production and uses of multipotent cell populations
CN101802172A (zh) * 2007-05-30 2010-08-11 通用医疗公司 由体细胞产生多能细胞的方法
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US20120282229A1 (en) 2007-08-01 2012-11-08 Christian Kannemeier Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
US20090191160A1 (en) 2007-08-10 2009-07-30 University Of Dayton Methods of producing pluripotent stem-like cells
CN101855338B (zh) 2007-08-31 2013-07-17 怀特黑德生物医学研究所 在程序重排体细胞中的wnt途径刺激
WO2009057831A1 (ja) 2007-10-31 2009-05-07 Kyoto University 核初期化方法
US20110151447A1 (en) 2007-11-06 2011-06-23 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells
US9005966B2 (en) 2007-11-19 2015-04-14 The Regents Of The University Of California Generation of pluripotent cells from fibroblasts
AU2008286249B2 (en) * 2007-12-10 2013-10-10 Kyoto University Efficient method for nuclear reprogramming
US9683232B2 (en) * 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
US20090191171A1 (en) * 2008-01-18 2009-07-30 Yupo Ma Reprogramming of Differentiated Progenitor or Somatic Cells Using Homologous Recombination
KR101481164B1 (ko) 2008-01-30 2015-01-09 주식회사 미래셀바이오 체세포 유래 다능성 줄기세포의 제조 방법
US20110014164A1 (en) 2008-02-15 2011-01-20 President And Fellows Of Harvard College Efficient induction of pluripotent stem cells using small molecule compounds
BRPI0908708A2 (pt) * 2008-03-17 2019-09-24 Scripps Research Inst métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desdiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de células tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, métodos para produzir células tronco pluripotentes induzidas a partir de células não pluripotentes de mamífero, para triar quanto a agentes que induzam a reprogramação ou desiferenciação de células de mamífero dentro das células tronco pluripotentes, para triar quanto a células de mamífero com características de célula tronco pluripotente, para induzir a expressão de oct4 em uma célula e para induzir células não pluripotentes em células pluripotentes, mistura, célula de mamífero, composição, e, kit
US20110061118A1 (en) 2008-03-17 2011-03-10 Helmholtz Zentrum Munchen Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination
CN101250502A (zh) 2008-04-01 2008-08-27 中国科学院上海生命科学研究院 一种诱导的多潜能干细胞的制备方法
CN101550406B (zh) * 2008-04-03 2016-02-10 北京大学 制备多潜能干细胞的方法,试剂盒及用途
US20100021437A1 (en) * 2008-04-07 2010-01-28 The McLean Hospital Corporation Whitehead Institute for Biomedical Research Neural stem cells derived from induced pluripotent stem cells
CA2695522C (en) 2008-05-02 2019-01-15 Kyoto University Method of nuclear reprogramming
EP2128245A1 (en) 2008-05-27 2009-12-02 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Generation of induced pluripotent stem (iPS) cells
EP3447128A1 (en) * 2008-06-04 2019-02-27 FUJIFILM Cellular Dynamics, Inc. Methods for the production of ips cells using non-viral approach
KR101372752B1 (ko) 2008-07-31 2014-03-14 고꾸리츠 다이가꾸호오징 기후다이가꾸 유도된 다능성 줄기 세포의 효율적인 확립 방법
US20100062534A1 (en) * 2008-09-09 2010-03-11 The General Hospital Corporation Inducible lentiviral vectors for reprogramming somatic cells
ES2959327T3 (es) 2008-10-24 2024-02-23 Wisconsin Alumni Res Found Células madre pluripotentes obtenidas mediante reprogramación no vírica

Also Published As

Publication number Publication date
JP4183742B1 (ja) 2008-11-19
MX352337B (es) 2017-11-21
AU2006325975A1 (en) 2007-06-21
CA2632142C (en) 2013-08-06
EP1970446B1 (en) 2011-08-03
PT1970446E (pt) 2011-09-01
EP2208786B1 (en) 2018-08-01
JP4411362B2 (ja) 2010-02-10
JPWO2007069666A1 (ja) 2009-05-21
IL191903A (en) 2011-11-30
EP1970446A1 (en) 2008-09-17
JP5467223B2 (ja) 2014-04-09
EP4223769A3 (en) 2023-11-01
CN103113463A (zh) 2013-05-22
EA200870046A1 (ru) 2009-12-30
CN101864392B (zh) 2016-03-23
JP4411363B2 (ja) 2010-02-10
EP2208786A1 (en) 2010-07-21
ZA200804673B (en) 2009-11-25
JP2009165478A (ja) 2009-07-30
KR20080095852A (ko) 2008-10-29
EA201000858A1 (ru) 2011-02-28
BRPI0619794B1 (pt) 2020-09-15
CN101356270A (zh) 2009-01-28
JP2008283972A (ja) 2008-11-27
EP2206724A1 (en) 2010-07-14
JP5603282B2 (ja) 2014-10-08
EP2206778B1 (en) 2018-08-01
US20090068742A1 (en) 2009-03-12
BRPI0619794A2 (pt) 2011-10-18
CN101356270B (zh) 2014-02-12
JP5098028B2 (ja) 2012-12-12
CN101864392A (zh) 2010-10-20
CA2632142A1 (en) 2007-06-21
JP2009165480A (ja) 2009-07-30
EA014166B1 (ru) 2010-10-29
JP5248371B2 (ja) 2013-07-31
NZ569530A (en) 2011-07-29
EA018039B1 (ru) 2013-05-30
MX2008007654A (es) 2008-09-26
EP2206778A1 (en) 2010-07-14
ES2367525T3 (es) 2011-11-04
EP4223769A2 (en) 2023-08-09
JP2014000083A (ja) 2014-01-09
EP3418297A1 (en) 2018-12-26
KR101420740B1 (ko) 2014-07-17
BRPI0619794B8 (pt) 2022-06-14
CN103773804A (zh) 2014-05-07
DK1970446T3 (da) 2011-10-24
US8048999B2 (en) 2011-11-01
JP5943324B2 (ja) 2016-07-05
IL191903A0 (en) 2008-12-29
JP2009165479A (ja) 2009-07-30
EP1970446A4 (en) 2009-04-08
HK1125967A1 (en) 2009-08-21
JP2009165481A (ja) 2009-07-30
AU2006325975B2 (en) 2011-12-08
WO2007069666A1 (ja) 2007-06-21
JP2011188860A (ja) 2011-09-29
EP3418297B1 (en) 2023-04-05
CN103113463B (zh) 2015-02-18

Similar Documents

Publication Publication Date Title
HK1125131A1 (en) Nuclear reprogramming factor
EP2896690A3 (en) Use of RNA for reprogramming somatic cells
EP1812556A4 (en) NEURONAL PRECURSORS OF FEEDER-FREE HUMAN EMBRYONIC STEM CELL CULTURE
IL267371B (en) Prolipotent stem cell growth medium, containing human serum, and without a nutrient layer
WO2006070370A3 (en) Stem cells culture systems
GB2449772A (en) Large scale production of stem cells
ZA201606403B (en) Pluripotent stem cell culture on micro-carriers
WO2010120785A3 (en) Methods and compositions for stem cell cultures
EP1572984B8 (en) Feeder-free, xeno-free culture system for human embryonic stem cells
IL190322A0 (en) Nutrient medium for the cultivation of a cell culture
EP2046946B8 (en) Pluripotent stem cell culture
WO2008151058A3 (en) Methods of generating pluripotent cells from somatic cells
WO2007098150A3 (en) Photobioreactor and uses therefor
IL178232A0 (en) Methods for growing pluripotent stem cells
ZA201000715B (en) Single pluripotent stem cell culture
WO2009132063A3 (en) Pluripotent cells
EP2344632A4 (en) METHOD FOR INDUCING PLURIPOTENCE IN CELLS
WO2011062963A3 (en) Induced puripotent stem cells and related methods
PH12015500618A1 (en) Plant regulatory elements and uses thereof
WO2009073523A3 (en) De-differentiation of human cells
GB0801215D0 (en) Cell re-programming
CR8547A (es) Composiciones y metodos relacionados con el cultivo de celulas madre neurales con celulas estromales de medula osea
WO2007022348A3 (en) Amplification of cell polulations from embryonic stem cells
EP3133150A3 (en) Derivation of embryonic stem cells and embryo-derived cells
WO2006088747A3 (en) Serum-free reagents for the isolation, cultivation, and cryopreservation of postnatal pluripotent epiblast-like stem cells