SG10201503652WA - Differentiation of human embryonic stem cells - Google Patents

Differentiation of human embryonic stem cells

Info

Publication number
SG10201503652WA
SG10201503652WA SG10201503652WA SG10201503652WA SG10201503652WA SG 10201503652W A SG10201503652W A SG 10201503652WA SG 10201503652W A SG10201503652W A SG 10201503652WA SG 10201503652W A SG10201503652W A SG 10201503652WA SG 10201503652W A SG10201503652W A SG 10201503652WA
Authority
SG
Singapore
Prior art keywords
differentiation
stem cells
embryonic stem
human embryonic
human
Prior art date
Application number
SG10201503652WA
Inventor
Jean Xu
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US33383110P priority Critical
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of SG10201503652WA publication Critical patent/SG10201503652WA/en

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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/54Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0603Embryonic cells ; Embryoid bodies
    • C12N5/0606Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/117Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/15Transforming growth factor beta (TGF-β)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/155Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/41Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70Enzymes
    • C12N2501/72Transferases (EC 2.)
    • C12N2501/727Kinases (EC 2.7.)
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/998Proteins not provided for elsewhere
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
SG10201503652WA 2010-05-12 2011-05-11 Differentiation of human embryonic stem cells SG10201503652WA (en)

Priority Applications (1)

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US33383110P true 2010-05-12 2010-05-12

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SG10201503652WA true SG10201503652WA (en) 2015-08-28

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SG2012082855A SG185511A1 (en) 2010-05-12 2011-05-11 Differentiation of human embryonic stem cells

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Country Status (16)

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US (2) US9752125B2 (en)
EP (2) EP2569419B1 (en)
JP (3) JP6050225B2 (en)
KR (2) KR101903562B1 (en)
CN (2) CN102884176B (en)
AR (1) AR081040A1 (en)
AU (1) AU2011250912A1 (en)
BR (1) BR112012028855A2 (en)
CA (1) CA2800610A1 (en)
DK (1) DK2569419T3 (en)
MX (1) MX351515B (en)
PH (1) PH12018500672A1 (en)
RU (2) RU2663339C1 (en)
SG (2) SG10201503652WA (en)
WO (1) WO2011143299A2 (en)
ZA (1) ZA201209383B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
CN107574142A (en) 2007-11-27 2018-01-12 生命扫描有限公司 Differentiation of human embryonic stem cells
MX2010009251A (en) 2008-02-21 2010-11-25 Centocor Ortho Biotech Inc Methods, surface modified plates and compositions for cell attachment, cultivation and detachment.
JP5734183B2 (en) 2008-06-30 2015-06-17 ヤンセン バイオテツク,インコーポレーテツド Differentiation of pluripotent stem cells
JP2012507289A (en) 2008-10-31 2012-03-29 ヤンセン バイオテツク,インコーポレーテツド Differentiation into pancreatic endocrine system of human embryonic stem cells
AU2009308967C1 (en) 2008-10-31 2017-04-20 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
CA2744234C (en) 2008-11-20 2018-11-06 Centocor Ortho Biotech Inc. Pluripotent stem cell culture on micro-carriers
KR101687344B1 (en) 2008-11-20 2016-12-16 얀센 바이오테크 인코포레이티드 Methods and compositions for cell attachment and cultivation on planar substrates
AU2010276438B2 (en) 2009-07-20 2015-06-11 Janssen Biotech Inc. Differentiation of human embryonic stem cells
AU2010333839C1 (en) 2009-12-23 2016-07-21 Janssen Biotech Inc. Differentiation of human embryonic stem cells
AU2011223900A1 (en) 2010-03-01 2012-09-13 Janssen Biotech, Inc. Methods for purifying cells derived from pluripotent stem cells
SG10201503652WA (en) 2010-05-12 2015-08-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
WO2012030538A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
EP2611910B1 (en) 2010-08-31 2018-01-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN105143446A (en) * 2011-12-22 2015-12-09 詹森生物科技公司 Differentiation of human embryonic stem cells into single hormonal insulin positive cells
WO2013134378A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
RU2018108847A3 (en) 2012-06-08 2019-02-26
AU2013280698B2 (en) * 2012-06-26 2019-01-17 Seraxis, Inc. Stem cells and pancreatic cells useful for the treatment of insulin-dependent diabetes mellitus
EP2893000B1 (en) 2012-09-03 2019-04-10 Novo Nordisk A/S Generation of pancreatic endoderm from pluripotent stem cells using small molecules
GB201216796D0 (en) * 2012-09-20 2012-11-07 Cambridge Entpr Ltd In vitro pancreatic differentiation
KR101942769B1 (en) * 2012-12-31 2019-01-28 얀센 바이오테크 인코포레이티드 Differentiation of human embryonic stem cells into pancreatic endocrine cells using hb9 regulators
BR112015015770A2 (en) * 2012-12-31 2017-07-11 Janssen Biotech Inc culturing human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
WO2015002724A2 (en) * 2013-06-11 2015-01-08 President And Fellows Of Harvard College SC-β CELLS AND COMPOSITIONS AND METHODS FOR GENERATING THE SAME
EP2896688A1 (en) * 2014-01-20 2015-07-22 Centre National de la Recherche Scientifique (CNRS) A method of producing beta pancreatic cells from progenitor cells through the use of hydrogen peroxide
KR20170002630A (en) 2014-05-16 2017-01-06 얀센 바이오테크 인코포레이티드 Use of small molecules to enhance mafa expression in pancreatic endocrine cells
EP3191583A1 (en) * 2014-09-08 2017-07-19 Fundación Pública Andaluza Progreso Y Salud Method for obtaining pancreatic beta cell surrogates by increasing pancreatic and duodenal homeobox 1 (pdx-1) expression
US10253298B2 (en) 2014-12-18 2019-04-09 President And Fellows Of Harvard College Methods for generating stem cell-derived beta cells and methods of use thereof
EP3234110A4 (en) 2014-12-18 2018-06-27 President and Fellows of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF
WO2016100921A1 (en) * 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF

Family Cites Families (241)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US709392A (en) 1902-05-06 1902-09-16 Haydn Brown Suture-clamp.
US2232142A (en) 1940-09-27 1941-02-18 Schumann Seymour Wound clip
US2814296A (en) 1954-04-15 1957-11-26 S & R J Everett & Co Ltd Surgical needles
US3209652A (en) 1961-03-30 1965-10-05 Burgsmueller Karl Thread whirling method
AT326803B (en) 1968-08-26 1975-12-29 Binder Fa G Knit fabric and method for making same
US3935067A (en) 1974-11-22 1976-01-27 Wyo-Ben Products, Inc. Inorganic support for culture media
CA1201400A (en) 1982-04-16 1986-03-04 Joel L. Williams Chemically specific surfaces for influencing cell activity during culture
US4499802A (en) 1982-09-29 1985-02-19 Container Graphics Corporation Rotary cutting die with scrap ejection
US4537773A (en) 1983-12-05 1985-08-27 E. I. Du Pont De Nemours And Company α-Aminoboronic acid derivatives
US4557264A (en) 1984-04-09 1985-12-10 Ethicon Inc. Surgical filament from polypropylene blended with polyethylene
US5089396A (en) 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5215893A (en) 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US4737578A (en) 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
US5863531A (en) 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5567612A (en) 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
US5759830A (en) 1986-11-20 1998-06-02 Massachusetts Institute Of Technology Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US4898156A (en) 1987-05-18 1990-02-06 Mitek Surgical Products, Inc. Suture anchor
NZ229354A (en) 1988-07-01 1990-09-26 Becton Dickinson Co Treating polymer surfaces with a gas plasma and then applying a layer of endothelial cells to the surface
EP0363125A3 (en) 1988-10-03 1990-08-16 Hana Biologics Inc. Proliferated pancreatic endocrine cell product and process
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
EP0628639B1 (en) 1991-04-25 1999-06-23 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
US5449383A (en) 1992-03-18 1995-09-12 Chatelier; Ronald C. Cell growth substrates
GB9206861D0 (en) 1992-03-28 1992-05-13 Univ Manchester Wound healing and treatment of fibrotic disorders
CA2114282A1 (en) 1993-01-28 1994-07-29 Lothar Schilder Multi-layered implant
JP3525221B2 (en) 1993-02-17 2004-05-10 味の素株式会社 Immunosuppressive agents
US5341922A (en) 1993-02-24 1994-08-30 Ethicon, Inc. Peelable foil suture packaging
WO1994023572A1 (en) 1993-04-08 1994-10-27 Human Cell Cultures, Inc. Cell culturing method and medium
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
GB9310557D0 (en) 1993-05-21 1993-07-07 Smithkline Beecham Plc Novel process and apparatus
TW257671B (en) 1993-11-19 1995-09-21 Ciba Geigy
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US5834308A (en) 1994-04-28 1998-11-10 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of Langerhans
WO2001023528A1 (en) 1999-09-27 2001-04-05 University Of Florida Research Foundation Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US6001647A (en) 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
ES2170815T5 (en) 1994-12-29 2012-11-14 Chugai Seiyaku Kabushiki Kaisha Using a PM-1 antibody or antibody MH166 for potentiating the antitumor effect of cisplatin or carboplatin
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5718922A (en) 1995-05-31 1998-02-17 Schepens Eye Research Institute, Inc. Intravitreal microsphere drug delivery and method of preparation
US5908782A (en) 1995-06-05 1999-06-01 Osiris Therapeutics, Inc. Chemically defined medium for human mesenchymal stem cells
BR9808998A (en) 1997-04-24 2000-08-08 Ortho Mcneil Pharm Inc Substituted imidazoles useful in the treatment of inflammatory diseases
AT358493T (en) 1997-07-03 2007-04-15 Osiris Therapeutics Inc Human mesenchymal stem cells from peripheral blood
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
DE69841578D1 (en) 1997-09-16 2010-05-06 Centocor Inc Methods for complete chemical synthesis and composition of genes and genomes
JP3880795B2 (en) 1997-10-23 2007-02-14 ジェロン・コーポレーションGeron Corporation In culture free of feeder cells, a method for growing primate-derived primordial stem cells
CO4980885A1 (en) 1997-12-29 2000-11-27 Ortho Mcneil Pharm Inc Triphenylpropanamide compounds useful in treating inflammation and methods for preparing said compound
EP1066052B1 (en) 1998-03-18 2006-02-01 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
MY132496A (en) 1998-05-11 2007-10-31 Vertex Pharma Inhibitors of p38
US6413773B1 (en) 1998-06-01 2002-07-02 The Regents Of The University Of California Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
US6610540B1 (en) 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
US6413556B1 (en) 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
IL144359D0 (en) 1999-01-21 2002-05-23 Vitro Diagnostics Inc Immortalized cell lines and methods of making the same
US6815203B1 (en) 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6685936B2 (en) 1999-10-12 2004-02-03 Osiris Therapeutics, Inc. Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
US20030082155A1 (en) 1999-12-06 2003-05-01 Habener Joel F. Stem cells of the islets of langerhans and their use in treating diabetes mellitus
WO2001042789A1 (en) 1999-12-13 2001-06-14 The Scripps Research Institute MARKERS FOR IDENTIFICATION AND ISOLATION OF PANCREATIC ISLET α AND β CELL PROGENITORS
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US7439064B2 (en) 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
KR100947577B1 (en) 2000-06-26 2010-03-15 가부시끼가이샤 히다치 세이사꾸쇼 Cell fraction containing cells capable of differentiating into nervous system cells
AT521353T (en) 2000-10-23 2011-09-15 Glaxosmithkline Llc New trisubstitutiertes 8h-pyridoä2,3- düpyrimidin-7-one derivative for treatment of CSBP / p38kinase mediated diseases
MXPA03005139A (en) 2000-12-08 2004-01-29 Ortho Mcneil Pharm Inc Macroheterocylic compounds useful as kinase inhibitors.
WO2002046183A2 (en) 2000-12-08 2002-06-13 Ortho-Mcneil Pharmaceutical, Inc. Indazolyl-substituted pyrroline compounds as kinase inhibitors
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
CA2435826A1 (en) 2001-01-24 2002-08-01 The Government Of The United States Of America Differentiation of stem cells to pancreatic endocrine cells
JP2004517932A (en) 2001-01-25 2004-06-17 アメリカ合衆国 Boronic acid compound formulation
US6656488B2 (en) 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
DE10290025T1 (en) 2001-04-19 2003-10-09 Develogen Ag A process for the differentiation of stem cells into insulin-producing cells
CN100516204C (en) 2001-04-24 2009-07-22 味之素株式会社 Stem cells and method of separating the same
JP2004531262A (en) 2001-05-15 2004-10-14 ラッパポート ファミリー インスチチュート フォア リサーチ イン ザ メディカル サイエンシズ Human embryonic stem cell-derived insulin-producing cells
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
KR100418195B1 (en) 2001-07-05 2004-02-11 주식회사 우리기술 Apparatus and method for multi-testing insulation of power cables
GB0117583D0 (en) 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
AU2002319780A1 (en) 2001-08-06 2003-02-24 Bresagen, Ltd. Alternative compositions and methods for the culture of stem cells
US6617152B2 (en) 2001-09-04 2003-09-09 Corning Inc Method for creating a cell growth surface on a polymeric substrate
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
JP2005506074A (en) 2001-10-18 2005-03-03 イクシオン・バイオテクノロジー・インコーポレーテッド Conversion of the stem and progenitor cells of the liver to the pancreas functional cells
AT438708T (en) 2001-11-15 2009-08-15 Childrens Medical Center A process for the isolation, expansion and differentiation of fetal stem cells from chorionzotte, amniotic fluid and the placenta, and therapeutic uses thereof
US20030161816A1 (en) 2001-12-07 2003-08-28 Fraser John K. Systems and methods for treating patients with processed lipoaspirate cells
IL162131D0 (en) 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
AU2002218893A1 (en) 2001-12-21 2003-07-09 Thromb-X Nv Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability
CA2471540A1 (en) 2001-12-28 2003-07-10 Cellartis Ab A method for the establishment of a pluripotent human blastocyst-derived stem cell line
US20030162290A1 (en) 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
CA2482716A1 (en) 2002-04-17 2003-10-23 Otsuka Pharmaceutical Co., Ltd. Method of forming pancreatic .beta. cells from mesenchymal cells
US20040161419A1 (en) 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
DE60319364T2 (en) 2002-05-08 2009-02-19 Janssen Pharmaceutica N.V. Substituted -pyrrolines as kinase inhibitors
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
US20090203141A1 (en) 2003-05-15 2009-08-13 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents
JP2006512046A (en) 2002-05-28 2006-04-13 ノボセル インコーポレイテッド Methods for the growth and transdifferentiation into insulin-producing cells of the human pancreatic acinar cells in invitro
BR0311821A (en) 2002-06-05 2005-04-05 Janssen Pharmaceutica Nv bisindolil-maleimid derivatives as kinase inhibitors
GB0212976D0 (en) 2002-06-06 2002-07-17 Tonejet Corp Pty Ltd Ejection method and apparatus
CN1171991C (en) 2002-07-08 2004-10-20 徐如祥 Culture process for human nerve stem cell
US6877147B2 (en) 2002-07-22 2005-04-05 Broadcom Corporation Technique to assess timing delay by use of layout quality analyzer comparison
US7838290B2 (en) 2002-07-25 2010-11-23 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
CA2494040A1 (en) 2002-07-29 2004-02-05 Es Cell International Pte Ltd. Multi-step method for the differentiation of insulin positive, glucose
US20040063204A1 (en) 2002-08-14 2004-04-01 Lijun Yang Bone marrow cell differentiation
US7371576B2 (en) 2002-09-06 2008-05-13 Reneuron, Inc. CD56 positive human adult pancreatic endocrine progenitor cells
US9969977B2 (en) 2002-09-20 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US20040062753A1 (en) 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
AU2003285172A1 (en) 2002-11-08 2004-06-03 The Johns Hopkins University Human embryonic stem cell cultures, and compositions and methods for growing same
US7144999B2 (en) 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
US20060040385A1 (en) 2002-12-05 2006-02-23 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
ES2571355T3 (en) 2002-12-16 2016-05-24 Technion Res & Dev Foundation Culture system without feeder cells or xenocontaminantes human embryonic stem cells
RU2359671C2 (en) 2003-01-29 2009-06-27 Такеда Фармасьютикал Компани Лимитед Method of obtaining of preparation with covering
BRPI0407074A (en) 2003-01-29 2006-01-24 Takeda Pharmaceutical Method for producing a coated preparation, coated preparation and method for improving the dissolution of pioglitazone hydrochloride in a preparation coated with pioglitazone hydrochloride
WO2005045001A2 (en) 2003-02-14 2005-05-19 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20070155661A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Standord Junior University Methods and compositions for modulating the development of stem cells
WO2004087885A2 (en) 2003-03-27 2004-10-14 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway
US20060194315A1 (en) 2003-03-31 2006-08-31 Condie Brian G Compositions and methods for the control, differentiaton and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway
CA2530533C (en) 2003-06-27 2015-02-10 Ethicon, Incorporated Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
IL161903D0 (en) 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
ITRM20030395A1 (en) 2003-08-12 2005-02-13 Istituto Naz Per Le Malattie Infettive Lazz Culture medium for the maintenance, proliferation and differentiation of mammalian cells.
WO2005017117A2 (en) 2003-08-14 2005-02-24 Martin Haas Multipotent amniotic fetal stem cells (mafsc) and banking of same
US7157275B2 (en) 2003-08-15 2007-01-02 Becton, Dickinson And Company Peptides for enhanced cell attachment and growth
US20060205072A1 (en) 2003-08-27 2006-09-14 Nobuko Uchida Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US6939633B2 (en) 2003-09-17 2005-09-06 General Motors Corporation Fuel cell shutdown and startup using a cathode recycle loop
JP2007515433A (en) 2003-12-17 2007-06-14 アラーガン インコーポレイテッドAllergan,Incorporated Cyp26a and methods of treatment selective inhibitors retinoid responsive disorder that use of cyp26b
US20060030042A1 (en) 2003-12-19 2006-02-09 Ali Brivanlou Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
CA2549605C (en) 2003-12-23 2013-05-07 Cythera, Inc. Definitive endoderm
CN109628371A (en) 2003-12-23 2019-04-16 维亚希特公司 Definitive entoderm
EP1740612A2 (en) 2004-04-27 2007-01-10 Cythera Inc. Pdx1 expressing endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
EP1786896B1 (en) 2004-07-09 2018-01-10 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
US20050233446A1 (en) 2003-12-31 2005-10-20 Parsons Xuejun H Defined media for stem cell culture
TWI334443B (en) 2003-12-31 2010-12-11 Ind Tech Res Inst Method of single cell culture of undifferentiated human embryonic stem cells
WO2005071066A1 (en) 2004-01-23 2005-08-04 Board Of Regents, The University Of Texas System Methods and compositions for preparing pancreatic insulin secreting cells
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
US20070298453A1 (en) 2004-02-12 2007-12-27 University Of Newcastle Upon Tyne Stem Cells
WO2005080598A1 (en) 2004-02-19 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. Method of screening somatic cell nucleus initializer
CA2581424A1 (en) 2004-03-09 2005-09-22 Gang Xu Methods for generating insulin-producing cells
CA2558486A1 (en) 2004-03-10 2005-09-22 Alberto Hayek Compositions and methods for growth of embryonic stem cells
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
JP4491014B2 (en) 2004-04-01 2010-06-30 ウイスコンシン アラムニ リサーチ ファンデーション Differentiation into endoderm and pancreatic lineage of stem cells
GB0410011D0 (en) * 2004-05-05 2004-06-09 Novartis Forschungsstiftung Neural cell differentiation method
KR20070083559A (en) 2004-08-13 2007-08-24 더 유니버시티 오브 죠지아 리서치 파운데이션, 인코포레이티드 Compositions and methods for self-renewal and differentiation in human embryonic stem cells
WO2006026473A2 (en) 2004-08-25 2006-03-09 University Of Georgia Research Foundation, Inc. METHODS AND COMPOSITIONS UTILIZING MYC AND GSK3ß TO MANIPULATE THE PLURIPOTENCY OF EMBRYONIC STEM CELLS
DE102004043256B4 (en) 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Scalable process for cultivating undifferentiated stem cells in suspension
BRPI0514778B1 (en) 2004-09-08 2018-07-10 Wisconsin Alumni Research Foundation Medium for culturing embryonic stem cells
AU2005282414C1 (en) 2004-09-08 2011-04-07 Wisconsin Alumni Research Foundation Culturing human embryonic stem cells
JP2008528038A (en) 2005-01-31 2008-07-31 エス セル インターナショナル ピーティーイー リミテッド Directed differentiation and use of embryonic stem cells
WO2006094286A2 (en) 2005-03-04 2006-09-08 John O'neil Adult pancreatic derived stromal cells
GB0505970D0 (en) 2005-03-23 2005-04-27 Univ Edinburgh Culture medium containing kinase inhibitor, and uses thereof
US7998938B2 (en) 2005-04-15 2011-08-16 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
CN100425694C (en) 2005-04-15 2008-10-15 北京大学 Method of inducing embryo stem cell to differentiate toward pancreatic cell
US20080208351A1 (en) 2005-04-26 2008-08-28 Aarhus Universitet Biocompatible Material for Surgical Implants and Cell Guiding Tissue Culture Surfaces
JP4557797B2 (en) 2005-05-20 2010-10-06 株式会社日立エルジーデータストレージ Optical disk device
KR20080024194A (en) 2005-06-10 2008-03-17 더 스크립스 리서치 인스티튜트 Compounds that maintain pluripotency of embryonic stem cells
WO2006138433A2 (en) 2005-06-14 2006-12-28 The Regents Of The University Of California Induction of cell differentiation by class i bhlh polypeptides
EP1931764A1 (en) 2005-06-21 2008-06-18 GE Healthcare Bio-Sciences AB Method for cell culture
EP1910516B1 (en) 2005-06-22 2019-06-19 Asterias Biotherapeutics, Inc. Suspension culture of human embryonic stem cells
US8778919B2 (en) 2005-06-30 2014-07-15 Janssen Pharmaceutica Nv Cyclic anilino—pyridinotriazines
US20080194021A1 (en) 2005-07-29 2008-08-14 Mays Robert W Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells
WO2007012144A1 (en) 2005-07-29 2007-02-01 Australian Stem Cell Centre Limited Compositions and methods for growth of pluripotent cells
WO2007025234A2 (en) 2005-08-26 2007-03-01 The Trustees Of Columbia University In The City Of New York Generation of pancreatic endocrine cells from primary duct cell cultures and methods of use for treatment of diabetes
CN101341244A (en) 2005-09-02 2009-01-07 新加坡科技研究局 Method of deriving mesenchymal stem cells
GB2444686B (en) 2005-09-12 2010-08-25 Es Cell Int Pte Ltd Differentiation of pluripotent stem cells using p38 MAPK inhibitors or prostaglandins
AU2006304318B2 (en) 2005-10-14 2012-12-06 Regents Of The University Of Minnesota Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype
ES2687233T3 (en) 2005-10-27 2018-10-24 Viacyte, Inc. Endoderm of dorsal and ventral foregut expressing PDX-1
JP5098028B2 (en) 2005-12-13 2012-12-12 国立大学法人京都大学 Nuclear reprogramming factor
WO2007082963A1 (en) 2006-01-18 2007-07-26 Fundación Instituto Valenciano De Infertilidad Human embryo stem-cell lines and methods for using same
DK2420565T3 (en) 2006-02-23 2017-12-04 Viacyte Inc Useful compositions and methods for culturing the differentiable cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
WO2008013664A2 (en) 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
EP1999253B1 (en) 2006-03-02 2019-05-22 Viacyte, Inc. Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
AU2007244675A1 (en) 2006-04-28 2007-11-08 Lifescan, Inc. Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
WO2007130474A2 (en) 2006-05-02 2007-11-15 Wisconsin Alumni Research Foundation Method of differentiating stem cells into cells of the endoderm and pancreatic lineage
US7964402B2 (en) 2006-05-25 2011-06-21 Sanford-Burnham Medical Research Institute Methods for culture and production of single cell populations of human embryonic stem cells
CN101541953A (en) 2006-06-02 2009-09-23 佐治亚大学研究基金会 Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
AU2007254766A1 (en) 2006-06-02 2007-12-13 University Of Georgia Research Foundation, Inc. Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
CN100494359C (en) 2006-06-23 2009-06-03 中日友好医院 Method for in vitro amplifying and in 3D solid culturing for nerve stem cell
ES2610812T3 (en) 2006-06-26 2017-05-03 Lifescan, Inc. Culturing pluripotent stem cells
US20080003676A1 (en) 2006-06-26 2008-01-03 Millipore Corporation Growth of embryonic stem cells
GB2454386B (en) 2006-07-06 2011-07-06 Es Cell Int Pte Ltd Method for embryonic stem cell culture on a positively charged support surface
KR101331510B1 (en) 2006-08-30 2013-11-20 재단법인서울대학교산학협력재단 Media compostions containing low concentrations of glucose useful for human embryonic stem cells, differentiation method of human embryonic stem cells into insulin-producing cells or cell clusters using thereof, and insulin-producing cells or cell clusters differentiated thereby
JP2008099662A (en) 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research Method for culturing stem cell
WO2008039521A2 (en) 2006-09-26 2008-04-03 Nmt Medical, Inc. Method for modifying a medical implant surface for promoting tissue growth
US20100323442A1 (en) 2006-10-17 2010-12-23 Emmanuel Edward Baetge Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
AU2007311026B2 (en) 2006-10-17 2012-05-17 Stiefel Laboratories, Inc. Talarazole metabolites
WO2008048671A1 (en) 2006-10-18 2008-04-24 University Of Illinois Embryonic-like stem cells derived from adult human peripheral blood and methods of use
EP2088190A4 (en) 2006-11-09 2011-01-05 Japan Government Method for culture and passage of primate embryonic stem cell, and method for induction of differentiation of the embryonic stem cell
EP2084269A2 (en) * 2006-11-20 2009-08-05 Octagene GmbH Genetic ablation of the prp gene cells using a targeted promoter trap strategy for production of serum-free recombinant proteins as therapeuticals
TW200836749A (en) 2007-01-09 2008-09-16 Vioquest Pharmaceuticals Inc Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
EP2126045A4 (en) 2007-01-30 2010-05-26 Univ Georgia Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
GB0703188D0 (en) 2007-02-19 2007-03-28 Roger Land Building Large scale production of stem cells
US7688908B2 (en) 2007-03-12 2010-03-30 Samsung Electronics Co., Ltd. System and method for processing wireless high definition video data using a shortened last codeword
WO2008148105A1 (en) 2007-05-25 2008-12-04 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
WO2009012428A2 (en) 2007-07-18 2009-01-22 Lifescan, Inc. Differentiation of human embryonic stem cells
CA2695225A1 (en) 2007-07-31 2009-02-05 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic endocrine
ES2648128T3 (en) 2007-07-31 2017-12-28 Lifescan, Inc. Differentiation of pluripotent stem cells using human feeder cells
KR101544498B1 (en) 2007-08-24 2015-08-17 스티칭 허트 네덜란드 칸커 인스티튜트 Compositions for the treatment of neoplastic diseases
WO2009061442A1 (en) 2007-11-06 2009-05-14 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells
CN107574142A (en) * 2007-11-27 2018-01-12 生命扫描有限公司 Differentiation of human embryonic stem cells
SG154367A1 (en) 2008-01-31 2009-08-28 Es Cell Int Pte Ltd Method of differentiating stem cells
WO2009096049A1 (en) 2008-02-01 2009-08-06 Kyoto University Differentiated cells originating in artificial pluripotent stem cells
US20100330677A1 (en) 2008-02-11 2010-12-30 Cambridge Enterprise Limited Improved Reprogramming of Mammalian Cells, and Cells Obtained
MX2010009251A (en) 2008-02-21 2010-11-25 Centocor Ortho Biotech Inc Methods, surface modified plates and compositions for cell attachment, cultivation and detachment.
WO2009110215A1 (en) 2008-03-03 2009-09-11 独立行政法人 科学技術振興機構 Method for induction of ciliated cell differentiation
US8716018B2 (en) 2008-03-17 2014-05-06 Agency For Science, Technology And Research Microcarriers for stem cell culture
EP2727998B1 (en) 2008-04-21 2019-06-12 Viacyte, Inc. Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells
US8338170B2 (en) * 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8728812B2 (en) * 2008-04-22 2014-05-20 President And Fellows Of Harvard College Compositions and methods for promoting the generation of PDX1+ pancreatic cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
DK2297319T3 (en) 2008-06-03 2015-10-19 Viacyte Inc Growth factors for the preparation of the definitive endoderm
US20090298178A1 (en) 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
JP5734183B2 (en) 2008-06-30 2015-06-17 ヤンセン バイオテツク,インコーポレーテツド Differentiation of pluripotent stem cells
DE102008032236A1 (en) 2008-06-30 2010-04-01 Eberhard-Karls-Universität Tübingen Isolation and / or identification of stem cells with adipozytärem, chondrozytärem and pancreatic differentiation potential
US20100028307A1 (en) 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
JP2012507289A (en) 2008-10-31 2012-03-29 ヤンセン バイオテツク,インコーポレーテツド Differentiation into pancreatic endocrine system of human embryonic stem cells
AU2009308967C1 (en) 2008-10-31 2017-04-20 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
CN102361970B (en) 2008-11-04 2018-03-27 韦尔赛特公司 Stem cell aggregates suspended composition and method for differentiation
CN102282254B (en) 2008-11-14 2015-12-16 维赛特公司 Pancreatic cells derived from human pluripotent stem cells encapsulated
CA2744234C (en) 2008-11-20 2018-11-06 Centocor Ortho Biotech Inc. Pluripotent stem cell culture on micro-carriers
WO2010063848A1 (en) 2008-12-05 2010-06-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Method and medium for neural differentiation of pluripotent cells
WO2010091241A2 (en) * 2009-02-06 2010-08-12 President And Fellows Of Harvard College Compositions and methods for promoting the generation of definitive endoderm
AU2010276438B2 (en) 2009-07-20 2015-06-11 Janssen Biotech Inc. Differentiation of human embryonic stem cells
RU2540016C2 (en) 2009-07-20 2015-01-27 Янссен Байотек, Инк. Differentiating human embryonic stem cells
FI20096288A0 (en) 2009-12-04 2009-12-04 Kristiina Rajala Formulations and Methods for Culturing Stem Cells
AU2010333839C1 (en) 2009-12-23 2016-07-21 Janssen Biotech Inc. Differentiation of human embryonic stem cells
EP2542666A4 (en) 2010-03-02 2014-05-07 Univ Singapore Culture additives to boost stem cell proliferation and differentiation response
CN105176930A (en) 2010-03-31 2015-12-23 斯克里普斯研究所 Reprogramming cells
JP2013524836A (en) 2010-04-25 2013-06-20 マウント・シナイ・スクール・オブ・メディスン Generation of front foregut endoderm from pluripotent cells
SG10201503652WA (en) 2010-05-12 2015-08-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
KR101829488B1 (en) 2010-08-05 2018-02-14 위스콘신 얼럼나이 리서어치 화운데이션 Simplified basic media for human pluripotent cell culture
CA2809305C (en) 2010-08-31 2019-06-11 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
WO2012117333A1 (en) 2011-02-28 2012-09-07 Stempeutics Research Malaysia Sdn Bhd Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof
WO2013055834A2 (en) 2011-10-11 2013-04-18 The New York Stem Cell Foundation Er stress relievers in beta cell protection
CN105143446A (en) 2011-12-22 2015-12-09 詹森生物科技公司 Differentiation of human embryonic stem cells into single hormonal insulin positive cells
US20130224156A1 (en) 2012-02-29 2013-08-29 Riken Method of producing human retinal pigment epithelial cells
RU2018108847A3 (en) 2012-06-08 2019-02-26
WO2014152321A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof

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