AU6339399A - Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors - Google Patents

Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors

Info

Publication number
AU6339399A
AU6339399A AU63393/99A AU6339399A AU6339399A AU 6339399 A AU6339399 A AU 6339399A AU 63393/99 A AU63393/99 A AU 63393/99A AU 6339399 A AU6339399 A AU 6339399A AU 6339399 A AU6339399 A AU 6339399A
Authority
AU
Australia
Prior art keywords
renewal
promotion
self
stem cells
hematopoietic stem
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU63393/99A
Inventor
Beth Louise Hill
Judy Carol Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of AU6339399A publication Critical patent/AU6339399A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/145—Thrombopoietin [TPO]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/2306—Interleukin-6 (IL-6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]
    • C12N2501/235—Leukemia inhibitory factor [LIF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
AU63393/99A 1998-10-16 1999-10-14 Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors Abandoned AU6339399A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US17363398A 1998-10-16 1998-10-16
US09173633 1998-10-16
US13247699P 1999-05-04 1999-05-04
US60132476 1999-05-04
PCT/EP1999/007741 WO2000023567A2 (en) 1998-10-16 1999-10-14 Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors

Publications (1)

Publication Number Publication Date
AU6339399A true AU6339399A (en) 2000-05-08

Family

ID=26830391

Family Applications (1)

Application Number Title Priority Date Filing Date
AU63393/99A Abandoned AU6339399A (en) 1998-10-16 1999-10-14 Promotion of self-renewal and improved gene transduction of hematopoietic stem cells by histone deacetylase inhibitors

Country Status (5)

Country Link
EP (1) EP1129175A2 (en)
JP (1) JP2002527101A (en)
AU (1) AU6339399A (en)
CA (1) CA2346152A1 (en)
WO (1) WO2000023567A2 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032669A (en) * 1990-05-01 1991-07-16 University Of Massachusetts At Amherst Liquid crystalline polyesters formed by reaction of bis(hydroxyalkoxy) biphenyls with terephthaloyl chloride
AU2002243231A1 (en) 2000-11-21 2002-07-24 Wake Forest University Method of treating autoimmune diseases
DE10162080A1 (en) * 2001-12-10 2003-06-26 Albrecht Mueller Process for the production of stem cells with increased development potential
ATE458047T1 (en) 2002-03-07 2010-03-15 Univ Delaware METHOD FOR ENHANCING OLIGONUCLEOTIDE-MEDIATED NUCLEIC ACID SEQUENCE CHANGE USING COMPOSITIONS CONTAINING A HYDROXYUREA
DE602004031283D1 (en) * 2004-05-05 2011-03-17 Zorica Becker-Kojic Use of glycoprotein ACA antibodies to obtain or maintain pluripotent non-embryonic stem cells
ATE527341T1 (en) * 2004-10-27 2011-10-15 Univ Bruxelles HEPATIC DIFFERENTIATION OF STEM CELLS
JP2009501236A (en) 2005-07-14 2009-01-15 タケダ サン ディエゴ インコーポレイテッド Histone deacetylase inhibitor
US8129187B2 (en) 2005-12-13 2012-03-06 Kyoto University Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
CN101864392B (en) 2005-12-13 2016-03-23 国立大学法人京都大学 Nuclear reprogramming factor
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
US9213999B2 (en) 2007-06-15 2015-12-15 Kyoto University Providing iPSCs to a customer
EP2268809B1 (en) 2008-05-02 2019-02-06 Kyoto University Method of nuclear reprogramming
WO2012046727A1 (en) 2010-10-05 2012-04-12 タカラバイオ株式会社 Method for producing virus vector
CN108220246B (en) 2011-09-30 2022-07-12 蓝鸟生物公司 Compounds for improving viral transduction
WO2013141133A1 (en) 2012-03-22 2013-09-26 タカラバイオ株式会社 Method for producing viral vector
WO2013146480A1 (en) * 2012-03-29 2013-10-03 タカラバイオ株式会社 Gene introduction method
JP6551963B2 (en) * 2014-05-14 2019-07-31 国立大学法人京都大学 Method for producing megakaryocyte precursor cells
WO2018088821A1 (en) * 2016-11-10 2018-05-17 울산대학교 산학협력단 Composition for promoting stem cell activity, comprising histone deacetylase inhibitor and priming factor as active ingredients
KR102097191B1 (en) * 2016-11-10 2020-04-06 울산대학교 산학협력단 Composition for enforcing the priming effect of stem cell comprising histone deacetylase inhibitor and priming factors
WO2021207673A1 (en) * 2020-04-09 2021-10-14 The Regents of the University of Colorodo, a body corporate Compositions, methods and uses for production of hematopoietic stem cells (hscs)
WO2021224633A1 (en) 2020-05-06 2021-11-11 Orchard Therapeutics (Europe) Limited Treatment for neurodegenerative diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ314644A (en) * 1993-05-24 2000-11-24 Immunex Corp Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue
US6060052A (en) * 1995-10-30 2000-05-09 Systemix, Inc. Methods for use of Mpl ligands with primitive human hematopoietic stem cells
EP0827742A1 (en) * 1996-09-04 1998-03-11 Vrije Universiteit Brussel Use of histone deacetylase inhibitors for treating fribosis or cirrhosis

Also Published As

Publication number Publication date
CA2346152A1 (en) 2000-04-27
JP2002527101A (en) 2002-08-27
WO2000023567A2 (en) 2000-04-27
EP1129175A2 (en) 2001-09-05
WO2000023567A3 (en) 2000-07-27

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase