PL3344758T3 - Sposób in vitro różnicowania populacji ludzkich pluripotentnych komórek macierzystych w populację komórek kardiomiocytów - Google Patents

Sposób in vitro różnicowania populacji ludzkich pluripotentnych komórek macierzystych w populację komórek kardiomiocytów

Info

Publication number
PL3344758T3
PL3344758T3 PL16767044T PL16767044T PL3344758T3 PL 3344758 T3 PL3344758 T3 PL 3344758T3 PL 16767044 T PL16767044 T PL 16767044T PL 16767044 T PL16767044 T PL 16767044T PL 3344758 T3 PL3344758 T3 PL 3344758T3
Authority
PL
Poland
Prior art keywords
cell population
differentiating
pluripotent stem
vitro method
human pluripotent
Prior art date
Application number
PL16767044T
Other languages
English (en)
Inventor
Stefan Robbert BRAAM
Ana Catarina Martins GRANDELA
Original Assignee
Ncardia B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ncardia B.V. filed Critical Ncardia B.V.
Publication of PL3344758T3 publication Critical patent/PL3344758T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/36—Lipids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/105—Insulin-like growth factors [IGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/375—Thyroid stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/415—Wnt; Frizzeled
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL16767044T 2015-09-01 2016-08-31 Sposób in vitro różnicowania populacji ludzkich pluripotentnych komórek macierzystych w populację komórek kardiomiocytów PL3344758T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL2015385 2015-09-01
EP16767044.7A EP3344758B1 (en) 2015-09-01 2016-08-31 An in vitro method of differentiating a human pluripotent stem cell population into a cardiomyocyte cell population
PCT/NL2016/050609 WO2017039445A1 (en) 2015-09-01 2016-08-31 An in vitro method of differentiating a human pluripotent stem cell population into a cardiomyocyte cell population

Publications (1)

Publication Number Publication Date
PL3344758T3 true PL3344758T3 (pl) 2022-01-03

Family

ID=56117922

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16767044T PL3344758T3 (pl) 2015-09-01 2016-08-31 Sposób in vitro różnicowania populacji ludzkich pluripotentnych komórek macierzystych w populację komórek kardiomiocytów

Country Status (8)

Country Link
US (2) US11136551B2 (pl)
EP (2) EP3344758B1 (pl)
DK (1) DK3344758T3 (pl)
ES (1) ES2895676T3 (pl)
HU (1) HUE057135T2 (pl)
PL (1) PL3344758T3 (pl)
PT (1) PT3344758T (pl)
WO (1) WO2017039445A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016131137A1 (en) 2015-02-17 2016-08-25 University Health Network Methods for making and using sinoatrial node-like pacemaker cardiomyocytes and ventricular-like cardiomyocytes
NL2019618B1 (en) 2017-09-22 2019-03-28 Ncardia B V In vitro method for providing stem cell derived cardiomyocytes
CN108913655B (zh) * 2018-07-16 2022-07-15 浙江大学 基于多能干细胞技术建立“人源性”心肌肥大模型的方法
JP2021530232A (ja) * 2018-07-17 2021-11-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California 免疫改変された多能性細胞から分化させた細胞
CA3139072A1 (en) 2019-05-03 2020-11-12 University Health Network Cardiomyocyte compositions and use thereof
US11162079B2 (en) 2019-05-10 2021-11-02 The Regents Of The University Of California Blood type O Rh-hypo-immunogenic pluripotent cells
AU2023204829A1 (en) * 2022-01-10 2024-07-11 Sana Biotechnology, Inc. Hypoimmune beta cells differentiated from pluripotent stem cells and related uses and methods
WO2024004960A1 (ja) * 2022-06-27 2024-01-04 武田薬品工業株式会社 細胞の培養方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0346429B1 (en) 1987-12-24 1994-12-28 Gropep Pty. Ltd. Peptide analogues of insulin-like growth factor 1 (igf-1) or factor 2 (igf-2)
DE69021335T2 (de) 1989-06-09 1996-04-11 Gropep Pty. Ltd., Adelaide Wachstumshormonfusionsproteine.
EP2206724A1 (en) 2005-12-13 2010-07-14 Kyoto University Nuclear reprogramming factor
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
US9683232B2 (en) 2007-12-10 2017-06-20 Kyoto University Efficient method for nuclear reprogramming
UA103918C2 (en) 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
EP4364797A3 (en) 2009-10-19 2024-07-10 FUJIFILM Cellular Dynamics, Inc. Cardiomyocyte production
JP5930205B2 (ja) 2010-08-26 2016-06-08 国立大学法人京都大学 多能性幹細胞の心筋分化促進剤
BR112013030166A2 (pt) 2011-06-09 2017-03-21 Hoffmann La Roche método de diferenciação de células haste pluripotentes em células leito vasculares, células endoteliais ou células dos músculos moles vasculares, banco biológico e uso de células endoteliais ou células dos músculos moles vasculares, composição terapêutica, métodos e usos.
WO2013019661A1 (en) 2011-07-29 2013-02-07 Cellular Dynamics International, Inc. Metabolic maturation in stem cell-derived tissue cells
WO2013056072A1 (en) * 2011-10-13 2013-04-18 Wisconsin Alumni Research Foundation Generation of cardiomyocytes from human pluripotent stem cells
WO2014078414A1 (en) 2012-11-13 2014-05-22 Joseph Wu Chemically defined production of cardiomyocytes from pluripotent stem cells
US9783550B2 (en) 2013-05-14 2017-10-10 The Board Of Regents Of The University Of Texas System Highly potent inhibitors of porcupine
EP3008172B1 (en) 2013-06-11 2020-05-06 Ncardia B.V. Culture medium compositions for maturating cardiomyocytes derived from pluripotent mammalian stem cells
US11001807B2 (en) 2013-07-02 2021-05-11 National University Of Singapore Differentiation of pluripotent stem cells and cardiac progenitor cells into striated cardiomyocyte fibers using laminins LN-511, LN-521 and LN-221
DK3047019T3 (da) * 2013-09-20 2019-08-26 Georg August Univ Goettingen Stiftung Oeffentlichen Rechts Univsmedizin Fremgangsmåde til at lede differentiering af pluripotente stamceller til funktionel hjertemuskel

Also Published As

Publication number Publication date
HUE057135T2 (hu) 2022-04-28
WO2017039445A1 (en) 2017-03-09
EP3344758A1 (en) 2018-07-11
EP3344758B1 (en) 2021-09-29
ES2895676T3 (es) 2022-02-22
US11136551B2 (en) 2021-10-05
EP3964565A1 (en) 2022-03-09
PT3344758T (pt) 2021-10-28
DK3344758T3 (da) 2021-11-01
US20220025333A1 (en) 2022-01-27
US20180251734A1 (en) 2018-09-06

Similar Documents

Publication Publication Date Title
PL3344758T3 (pl) Sposób in vitro różnicowania populacji ludzkich pluripotentnych komórek macierzystych w populację komórek kardiomiocytów
EP3344755A4 (en) PREPARATION SYSTEM FOR PLURIPOTENTE STEM CELLS AND METHOD FOR THE PRODUCTION OF INDUCED PLURIPOTENTAL STEM CELLS
EP3334820C0 (en) EXPANDED AND INDUCED PLURIPOTENT STEM CELLS, METHODS OF MANUFACTURE AND USE
EP3472304A4 (en) NEW AND EFFICIENT METHOD FOR REPROGRAMMING BLOOD IN INDUCED PLURIPOTENT STEM CELLS
SG11201701844YA (en) Methods of differentiating stem cells into liver cell lineages
EP3384007C0 (en) IMPROVED METHODS FOR REPROGRAMMING NON-PLURIPOTENT CELLS INTO PLURIPOTENT STEM CELLS
EP2966163A4 (en) CULTURE SYSTEM FOR PLURIPOTENT STEM CELLS AND METHOD FOR SUB-CULTURE OF PLURIPOTENT STEM CELLS
SG11201603047PA (en) Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
EP3272858A4 (en) Method for producing naïve pluripotent stem cells
HK1220487A1 (zh) 全能幹細胞的誘導方法、及用該方法製備的全能幹細胞
SG11201609916RA (en) Culture method and cell mass
SG11201706090SA (en) Cell culturing method and kit
EP3369809A4 (en) Method for obtaining leydig cells by carrying out induced differentiation on human induced pluripotent stem cells, and use of leydig cells
EP3070159A4 (en) METHOD AND PLANT FOR CURING PLURIPOTENT STEM CELLS
IL254156A0 (en) Methods for producing neural stem cells and their use
EP2949746A4 (en) METHOD OF SUB-CULTURE OF PLURIPOTENT STEM CELLS
LT3064573T (lt) Pliuripotentinių kamieninių ląstelių, indikuotų iš mezenchiminių kamieninių ląstelių, diferenciacijos į neuronus būdas
EP3196297A4 (en) Method for producing cardiomyocyte population from pluripotent stem cells
EP3202896A4 (en) Method for culturing pluripotent stem cells
IL263557B (en) Differentiation of pluripotent stem cells into iris cells
EP3702444A4 (en) METHOD FOR INDUCING THE DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN HEPATOCYTE
IL256093B (en) Method for multiplying and/or differentiating hematopoietic stem cells into progenitors and uses thereof
EP3088415A4 (en) Method for inducing differentiation of pluripotent stem cells into endodermal cells
EP3495471A4 (en) METHOD FOR INDUCING THE DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN VITRO
LT3156481T (lt) Indukuotų pluripotentinių kamieninių ląstelių gamybos būdas iš riebalinio audinio kilusių mezenchiminių kamieninių ląstelių ir tuo pačiu būdu pagamintos indukuotos pluripotentinės kamieninės ląstelės