DE69132521T2 - Homogenes testsystem - Google Patents

Homogenes testsystem

Info

Publication number
DE69132521T2
DE69132521T2 DE69132521T DE69132521T DE69132521T2 DE 69132521 T2 DE69132521 T2 DE 69132521T2 DE 69132521 T DE69132521 T DE 69132521T DE 69132521 T DE69132521 T DE 69132521T DE 69132521 T2 DE69132521 T2 DE 69132521T2
Authority
DE
Germany
Prior art keywords
test system
nucleic acid
sequence variants
homogeneous test
identify
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69132521T
Other languages
English (en)
Other versions
DE69132521T3 (de
DE69132521D1 (de
Inventor
H Gelfand
M Holland
K Saiki
M Watson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24251781&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69132521(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69132521D1 publication Critical patent/DE69132521D1/de
Publication of DE69132521T2 publication Critical patent/DE69132521T2/de
Publication of DE69132521T3 publication Critical patent/DE69132521T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6823—Release of bound markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
DE69132521T 1990-08-06 1991-08-06 Homogenes testsystem Expired - Lifetime DE69132521T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US563758 1990-08-06
US07/563,758 US5210015A (en) 1990-08-06 1990-08-06 Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
PCT/US1991/005571 WO1992002638A1 (en) 1990-08-06 1991-08-06 Homogeneous assay system

Publications (3)

Publication Number Publication Date
DE69132521D1 DE69132521D1 (de) 2001-03-01
DE69132521T2 true DE69132521T2 (de) 2001-09-06
DE69132521T3 DE69132521T3 (de) 2007-07-05

Family

ID=24251781

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69133574T Expired - Lifetime DE69133574T2 (de) 1990-08-06 1991-08-06 Verfahren zur Unterscheidung von Sequenz Varianten
DE69133329T Expired - Lifetime DE69133329T3 (de) 1990-08-06 1991-08-06 Markierte Oligonukleotide
DE69132521T Expired - Lifetime DE69132521T3 (de) 1990-08-06 1991-08-06 Homogenes testsystem

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE69133574T Expired - Lifetime DE69133574T2 (de) 1990-08-06 1991-08-06 Verfahren zur Unterscheidung von Sequenz Varianten
DE69133329T Expired - Lifetime DE69133329T3 (de) 1990-08-06 1991-08-06 Markierte Oligonukleotide

Country Status (10)

Country Link
US (6) US5210015A (de)
EP (3) EP1302549B1 (de)
JP (1) JP2825976B2 (de)
AT (3) ATE365812T1 (de)
AU (1) AU666837B2 (de)
CA (1) CA2088683C (de)
DE (3) DE69133574T2 (de)
DK (3) DK1302549T3 (de)
ES (3) ES2155058T5 (de)
WO (1) WO1992002638A1 (de)

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CA2088683C (en) 2000-03-28
DK0543942T4 (da) 2007-02-19
EP1302549B1 (de) 2007-06-27
ES2289190T3 (es) 2008-02-01
CA2088683A1 (en) 1992-02-07
US7445900B2 (en) 2008-11-04
EP0919565B2 (de) 2008-11-12
DK0919565T4 (da) 2009-01-12
JP2825976B2 (ja) 1998-11-18
US7141377B2 (en) 2006-11-28
WO1992002638A1 (en) 1992-02-20
US5487972A (en) 1996-01-30
ES2155058T5 (es) 2007-06-16
DE69133574D1 (de) 2007-08-09
EP0919565B1 (de) 2003-10-15
EP1302549A3 (de) 2004-01-14
EP0543942A1 (de) 1993-06-02
EP0919565A3 (de) 2000-11-15
DE69132521T3 (de) 2007-07-05
AU8651091A (en) 1992-03-02
AU666837B2 (en) 1996-02-29
US6214979B1 (en) 2001-04-10
EP0543942B2 (de) 2006-11-15
DK0919565T3 (da) 2004-02-16
US5210015A (en) 1993-05-11
JPH06500021A (ja) 1994-01-06
EP1302549A2 (de) 2003-04-16
DE69133329D1 (de) 2003-11-20
US20080171315A1 (en) 2008-07-17
ES2155058T3 (es) 2001-05-01
ATE198912T1 (de) 2001-02-15
DE69133329T2 (de) 2004-08-05
DE69132521D1 (de) 2001-03-01
ES2209033T3 (es) 2004-06-16
US20050255499A1 (en) 2005-11-17
EP0543942B1 (de) 2001-01-24
US5804375A (en) 1998-09-08
EP0919565A2 (de) 1999-06-02
DK0543942T3 (da) 2001-06-18
ATE252110T1 (de) 2003-11-15
DK1302549T3 (da) 2007-10-01
DE69133574T2 (de) 2008-03-06
ES2209033T5 (es) 2009-04-16
DE69133329T3 (de) 2009-07-09
ATE365812T1 (de) 2007-07-15

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