ATE88761T1 - Kompetitiver homogener test. - Google Patents

Kompetitiver homogener test.

Info

Publication number
ATE88761T1
ATE88761T1 AT87300195T AT87300195T ATE88761T1 AT E88761 T1 ATE88761 T1 AT E88761T1 AT 87300195 T AT87300195 T AT 87300195T AT 87300195 T AT87300195 T AT 87300195T AT E88761 T1 ATE88761 T1 AT E88761T1
Authority
AT
Austria
Prior art keywords
probe
sample
polynucleotide
deriv
aminoalkyl
Prior art date
Application number
AT87300195T
Other languages
English (en)
Inventor
Larry Edward Morrison
Original Assignee
Amoco Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25671322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE88761(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amoco Corp filed Critical Amoco Corp
Application granted granted Critical
Publication of ATE88761T1 publication Critical patent/ATE88761T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Steroid Compounds (AREA)
AT87300195T 1986-01-10 1987-01-09 Kompetitiver homogener test. ATE88761T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81784186A 1986-01-10 1986-01-10
EP87300195A EP0232967B1 (de) 1986-01-10 1987-01-09 Kompetitiver homogener Test
CA000535665A CA1296242C (en) 1986-01-10 1987-04-27 Competitive homogeneous assay

Publications (1)

Publication Number Publication Date
ATE88761T1 true ATE88761T1 (de) 1993-05-15

Family

ID=25671322

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87300195T ATE88761T1 (de) 1986-01-10 1987-01-09 Kompetitiver homogener test.

Country Status (6)

Country Link
US (1) US5928862A (de)
EP (1) EP0232967B1 (de)
JP (1) JP2619866B2 (de)
AT (1) ATE88761T1 (de)
CA (1) CA1296242C (de)
DE (1) DE3785591T2 (de)

Families Citing this family (205)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA877772B (en) * 1986-10-23 1988-04-20 Amoco Corporation Target and background capture methods and apparatus for affinity assays
KR960002234B1 (ko) * 1987-07-31 1996-02-13 젠-프로우브 인코오퍼레이티드 바람직하지 못한 교차반응을 제거하기 위한 올리고뉴클레오티드를 사용하는 폴리뉴클레오티드에 대한 측정방법
CA1338526C (en) * 1988-03-18 1996-08-20 Charles Thomas Caskey Mutation detection by competitive oligonucleotide priming
US5324829A (en) * 1988-12-16 1994-06-28 Ortho Diagnostic Systems, Inc. High specific activity nucleic acid probes having target recognition and signal generating moieties
GB8902689D0 (en) * 1989-02-07 1989-03-30 Ici Plc Assay method
EP0481999B1 (de) * 1989-03-10 1997-07-23 VYSIS, Inc. Interferenzverhinderung mit affinitätseinfangschemas
AU5269590A (en) 1989-03-10 1990-10-09 Gene-Trak Systems Immobilized oligonucleotide probes and uses therefor
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5800992A (en) 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
EP0529070A1 (de) * 1991-02-27 1993-03-03 Amoco Corporation Verfahren zur verbesserung der empfindlichkeit von hybridisierungsassays
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5340716A (en) * 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
GB9114525D0 (en) * 1991-07-05 1991-08-21 Delnatte Sabine Homogeneous nucleic acids probe based tests and substances
ES2159282T3 (es) * 1991-11-07 2001-10-01 Nanotronics Inc Hibridacion de polinucleotidos conjugados con cromoforas y fluoroforos con el fin de generar sistemas de transferencia de energia de donador a donador.
JP3939338B2 (ja) 1991-11-22 2007-07-04 アフィメトリックス, インコーポレイテッド ポリマー合成に対する組合わせの戦略
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US6864101B1 (en) 1991-11-22 2005-03-08 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
DK0653066T3 (da) * 1992-07-31 1998-09-23 Dade Behring Marburg Gmbh Fotoaktiverbare kemiluminescerende matricer
ATE319853T1 (de) * 1992-11-27 2006-03-15 Canon Kk Verfahren und sonde zum nachweis von nukleinsäuren
JPH06153997A (ja) * 1992-11-27 1994-06-03 Canon Inc 検出信号増幅による標的核酸の検出方法
EP0601889A2 (de) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nukleinsäure-Sonden
JP3247001B2 (ja) * 1992-12-21 2002-01-15 キヤノン株式会社 ピリリウム化合物を用いた2本鎖核酸の検出方法、ピリリウム化合物を含有するプローブ及びそれを用いた標的核酸の検出方法、新規ピリリウム化合物
CA2143428A1 (en) * 1993-07-09 1995-01-19 Takanori Oka Method of nucleic acid-differentiation and assay kit for nucleic acid-differentiation
US5861124A (en) * 1993-07-15 1999-01-19 Hamamatsu Photonics Kk Method and apparatus for detecting denaturation of nucleic acid
CA2126391C (en) * 1993-09-13 2002-01-08 Nobuko Yamamoto Determination of nucleic acid by pcr, measurement of number of microbial cells, genes, or gene-copies by pcr, and measuring-kit employed for the same
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
DK1921169T3 (da) * 1993-11-12 2012-06-04 Phri Properties Inc Hybridiseringssonder til nukleinsyredetektion, universelle stamceller, fremgangsmåder og kits
US6821727B1 (en) 1993-11-15 2004-11-23 Applera Corporation Hybridization assay using self-quenching fluorescence probe
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
JPH07233065A (ja) 1993-12-27 1995-09-05 Canon Inc ピリリウム塩又はピリリウム類似塩を含む光化学治療薬
WO1995032306A1 (en) * 1994-05-23 1995-11-30 Biotronics Corporation Method for detecting a target nucleic acid
DE69532255D1 (de) * 1994-05-26 2004-01-22 Canon Kk Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
EP0826066B1 (de) 1995-05-05 2000-09-13 The Perkin-Elmer Corporation Methoden and reagentien fuer die kombination einer pcr-amplifizierung mit einem hybridisierungs-assay
WO1997023647A1 (en) * 1995-12-22 1997-07-03 Behringwerke Aktiengesellschaft Homogeneous amplification and detection of nucleic acids
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US5716784A (en) * 1996-02-05 1998-02-10 The Perkin-Elmer Corporation Fluorescence detection assay for homogeneous PCR hybridization systems
AU713667B2 (en) * 1996-04-12 1999-12-09 Phri Properties, Inc. Detection probes, kits and assays
AU2735797A (en) * 1996-04-12 1998-03-26 Public Health Research Institute Of The City Of New York, Inc., The Detection probes, kits and assays
ATE318327T1 (de) * 1996-06-04 2006-03-15 Univ Utah Res Found Fluoreszenz-donor-akzeptor paar
EP0912767B1 (de) * 1996-07-16 2006-09-13 Gen-Probe Incorporated Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm)
US7070925B1 (en) 1996-07-16 2006-07-04 Gen-Probe Incorporated Method for determining the presence of an RNA analyte in a sample using a modified oligonucleotide probe
US5853990A (en) 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
ATE230801T1 (de) 1996-10-03 2003-01-15 Canon Kk Verfahren zur detektion von zielnukleinsäure, verfahren zu ihrer quantifizierung und pyrylium- verbindungen zur chemilumineszenz-analyse
US6451530B1 (en) * 1996-12-13 2002-09-17 The United States Of America As Represented By The Department Of Health And Human Services Fluorescent nucleotide analog hairpin formation for detection of nucleic acid hybridization
US6060242A (en) * 1997-02-27 2000-05-09 Lorne Park Research, Inc. PNA diagnostic methods
US6251591B1 (en) 1997-02-27 2001-06-26 Lorne Park Research, Inc. Quantitative method for detecting nucleotide concentration
US6046004A (en) * 1997-02-27 2000-04-04 Lorne Park Research, Inc. Solution hybridization of nucleic acids with antisense probes having modified backbones
ATE241018T1 (de) * 1997-02-27 2003-06-15 Ingeneus Corp Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden
US5846729A (en) * 1997-02-27 1998-12-08 Lorne Park Research, Inc. Assaying nucleotides in solution using a fluorescent intensity quenching effect
US7803528B1 (en) 1997-02-28 2010-09-28 Quest Diagnostics Incorporated Fluorescence energy transfer by competitive hybridization
US6103536A (en) 1997-05-02 2000-08-15 Silver Lake Research Corporation Internally referenced competitive assays
JPH1189598A (ja) * 1997-09-18 1999-04-06 Hitachi Software Eng Co Ltd 蛍光標識プローブ及びハイブリダイゼーション検出方法
US5935791A (en) 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
EP0988400A1 (de) * 1998-02-18 2000-03-29 Dade Behring Inc. Methoden zur quantifizierung von nukleinsäuren
US6255050B1 (en) 1998-05-22 2001-07-03 Lorne Park Research, Inc. Dynamic hybridization system
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
DE69941333D1 (de) 1998-07-02 2009-10-08 Gen Probe Inc Molekulare fackeln
US6037130A (en) * 1998-07-28 2000-03-14 The Public Health Institute Of The City Of New York, Inc. Wavelength-shifting probes and primers and their use in assays and kits
WO2000034521A1 (en) * 1998-12-08 2000-06-15 Boston Probes, Inc. Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices
DK1471926T3 (da) 1999-06-01 2011-02-28 Baylor College Medicine Sammensætninger og fremgangsmåder til terapeutisk anvendelse af en atonal-associeret sekvens
US6645733B1 (en) 1999-06-25 2003-11-11 Ingeneus Corporation Fluorescent intensity method for assaying binding between proteins or peptides
EP1226115A4 (de) 1999-10-04 2006-03-15 Univ New Jersey Med Carbamate und harnstoffe
US6376177B1 (en) 1999-10-06 2002-04-23 Virtual Pro, Inc. Apparatus and method for the analysis of nucleic acids hybridization on high density NA chips
DE19952568C2 (de) * 1999-11-02 2003-05-22 Noxxon Pharma Ag Fluoreszenzmarkierte Nukleinsäure-Liganden
GB2359625B (en) * 1999-12-10 2004-10-20 Molecular Light Tech Res Ltd Monitoring oligonucleotide binding process using chemiluminescence quenching
FI20000333A0 (fi) 2000-02-16 2000-02-16 Jussi Nurmi Homogeeninen menetelmä polynukleotidin havaitsemiseksi
CN1348096A (zh) 2000-10-10 2002-05-08 栾国彦 一种均相特异性检测核酸的探针及应用方法
US20060073530A1 (en) * 2001-08-15 2006-04-06 Olaf Schneewind Methods and compositions involving sortase B
US6593091B2 (en) 2001-09-24 2003-07-15 Beckman Coulter, Inc. Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
EP1478656B1 (de) 2002-02-01 2009-09-16 Life Technologies Corporation Oligonukleotidzusammensetzungen mit verbesserter effizienz
WO2003064621A2 (en) 2002-02-01 2003-08-07 Ambion, Inc. HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
EP1509624A2 (de) * 2002-05-31 2005-03-02 Secretary, Department Of Atomic Energy Methode für den nukleinsäurenachweis basierend auf met/fret wobei sich die fluorophoren gruppen auf komplementären strängen befinden
AU2003253651C1 (en) * 2002-06-14 2010-06-03 Gen-Probe Incorporated Compositions and methods for detecting hepatitis B virus
WO2004001074A1 (en) * 2002-06-21 2003-12-31 Lynx Therapeutics, Inc. Method for detecting foreign dna in a host genome
KR20120002613A (ko) 2002-08-12 2012-01-06 제네렉스, 인코포레이티드 폭스바이러스 및 암과 관련된 방법 및 조성물
AU2003269522A1 (en) * 2002-10-11 2004-05-04 Ahram Biosystems Inc. Target detection system having a conformationally sensitive probe comprising a nucleic acid based signal transducer
GB0303453D0 (en) * 2003-02-14 2003-03-19 Thermo Clinical Labsystems Oy Automated sample analyzer and cuvette
JP2006522329A (ja) 2003-03-07 2006-09-28 ラクセル・バイオサイエンシズ・リミテッド 酸素感受性プローブ
US7381811B2 (en) 2003-05-19 2008-06-03 Gen-Probe Incorporated Compositions and methods for detecting Trichomonas vaginalis in a sample
US7202036B2 (en) * 2003-06-12 2007-04-10 Los Alamos National Security, Llc Quenching methods for background reduction in luminescence-based probe-target binding assays
GB0320235D0 (en) * 2003-08-29 2003-10-01 Molecular Light Tech Res Ltd Estimation of activity or inhibition of processes involved in nucleic acid modification using chemiluminescence quenching
CA2548205C (en) * 2003-12-03 2017-06-27 Abbott Laboratories Double stranded linear nucleic acid probe and uses thereof
DE602004026111D1 (de) 2003-12-19 2010-04-29 Nat Inst Of Advanced Ind Scien Verfahren zum testen von nukleinsäuren unter verwendung davon sowie dafür zu verwendende nukleinsäuresonde
WO2006016978A1 (en) * 2004-06-30 2006-02-16 Applera Corporation Analog probe complexes
AU2005280162B2 (en) 2004-08-27 2012-04-26 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
DE602005021525D1 (de) 2004-09-14 2010-07-08 Univ Colorado R behandlung mit bucindolol
EP2348320B1 (de) 2005-03-10 2024-05-01 Gen-Probe Incorporated Verfahren und Systeme zur Erkennung mehrerer Fluoreszenzemissionssignale
US7932081B2 (en) 2005-03-10 2011-04-26 Gen-Probe Incorporated Signal measuring system for conducting real-time amplification assays
US8980246B2 (en) 2005-09-07 2015-03-17 Sillajen Biotherapeutics, Inc. Oncolytic vaccinia virus cancer therapy
DE06814528T1 (de) 2005-09-12 2012-01-05 The Regent Of The University Of Michigan Wiederkehrende genfusionen bei prostatakrebs
US9957569B2 (en) * 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
EP1945821B1 (de) 2006-06-06 2011-01-19 Gen-Probe Incorporated Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
EP2038432B1 (de) * 2006-06-30 2017-02-08 Rosetta Genomics Ltd Verfahren zum nachweis und zur quantifizierung von durch rt-pcr von mirna erzeugte ziel-nukleinsäuren
US8481023B2 (en) 2006-09-15 2013-07-09 Ottawa Hospital Research Institute Oncolytic rhabdovirus
PT1911852E (pt) * 2006-10-12 2009-10-09 Bio Rad Pasteur Sondas de cadeia dupla para a detecção fluorescente de ácidos nucleicos
US9273345B2 (en) * 2006-12-28 2016-03-01 Conceptual Mindworks, Inc. Methods and compositions for processes of rapid selection and production of nucleic acid aptamers
EP2126114B1 (de) * 2007-02-01 2016-09-28 Abacus Diagnostica OY Verfahren zum nachweis des vorliegens von zielpolynukleotid in proben
CN105441549A (zh) * 2007-03-30 2016-03-30 霍夫曼-拉罗奇有限公司 烷基胺改进甲醛固定的生物样品组分的检测
CA2691197C (en) 2007-06-21 2013-03-12 Gen-Probe Incorporated Instrument and receptacles for use in performing processes
JP5433572B2 (ja) 2007-07-06 2014-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン Mipol1−etv1遺伝子再編成
JP5529732B2 (ja) 2007-07-06 2014-06-25 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 前立腺癌における再発性遺伝子融合
US8790877B2 (en) * 2007-07-12 2014-07-29 The United States Of America As Represented By The Secretary Of The Air Force Using DNA aptamers and quantum dots for the detection of proteins or other targets
CA2719247C (en) * 2008-03-25 2017-03-21 The Regents Of The University Of Michigan Ikki inhibitor therapies and screening methods, and related ikki diagnostics
JP5252270B2 (ja) * 2008-04-25 2013-07-31 独立行政法人科学技術振興機構 核酸応答性ゲルおよびその製造方法ならびにその利用
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
EP2291553A4 (de) 2008-05-28 2011-12-14 Genomedx Biosciences Inc Systeme und verfahren zur expressionsbasierten unterscheidung unterschiedlicher klinischer krankheitsstadien bei prostatakrebs
US8034569B2 (en) * 2008-06-06 2011-10-11 Biotex, Inc. Methods for molecular detection
GB0909333D0 (en) 2009-06-01 2009-07-15 Fu Guoliang Multiplex amplification and detection
EP2307574B1 (de) 2008-07-31 2012-09-19 Oxitec Limited Multiple amplifikation und nachweis
EP2331703A2 (de) * 2008-09-12 2011-06-15 Promega Corporation Beurteilen der expression endogener und exogener gene
WO2010067055A1 (en) 2008-12-09 2010-06-17 Oxitec Ltd. Enhanced taqman probe based amplification
JP2012514475A (ja) 2009-01-09 2012-06-28 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 癌における再現性の遺伝子融合物
CA2750900C (en) 2009-01-30 2017-03-28 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
JP2010178716A (ja) * 2009-02-09 2010-08-19 Olympus Corp 標的核酸分子の定量方法及び標的核酸分子定量キット
WO2010114842A1 (en) 2009-03-30 2010-10-07 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
EP2430187A2 (de) * 2009-05-12 2012-03-21 Abacus Diagnostica OY Verfahren zum nachweis von nukleinsäuren
EP2449104B1 (de) 2009-06-29 2014-06-04 Luminex Corporation Chimäre primer mit haarnadel-konformationen und verwendungsverfahren dafür
US9409983B2 (en) 2009-07-23 2016-08-09 The Board Of Trustess Of The University Of Illinois Methods and compositions involving PBEF inhibitors for lung inflammation conditions and diseases
WO2011032088A1 (en) 2009-09-11 2011-03-17 Arca Biopharma, Inc. Polymorphisms in the pde3a gene
DK2477499T3 (en) 2009-09-14 2018-06-06 Sillajen Biotherapeutics Inc COMBINATION CANCER THERAPY WITH ONCOLYTIC VACCINIA VIRUS
AU2010295689B2 (en) * 2009-09-17 2014-02-13 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
EP2905332B1 (de) 2009-11-19 2018-09-12 Solis BioDyne OÜ Zusammensetzungen zur erhöhung der polypeptidstabilität und -aktivität und zugehörige verfahren
JP6025255B2 (ja) 2009-12-10 2016-11-16 ターンストーン リミテッド パートナーシップ 腫瘍退縮性ラブドウイルス
CA2822747A1 (en) 2009-12-23 2011-06-30 Arca Biopharma, Inc. Use of s-(6-nitro-oxi-hexahydro-furo[3,2-b]thioacetate in the treatment of cardiovascular disorders associated with oxide synthase dysfunction
US8383793B2 (en) 2010-04-15 2013-02-26 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
DE102010025161A1 (de) * 2010-06-25 2011-12-29 Qiagen Gmbh Verfahren zum Nachweis von Ribonukleinsäuren
DK2591363T3 (en) 2010-07-07 2017-12-11 Univ Michigan Regents DIAGNOSIS AND TREATMENT OF BREAST CANCER
CA2811333C (en) 2010-09-16 2020-05-12 Gen-Probe Incorporated Capture probes immobilizable via l-nucleotide tail
US20150218639A1 (en) 2014-01-17 2015-08-06 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10233501B2 (en) 2010-10-19 2019-03-19 Northwestern University Biomarkers predictive of predisposition to depression and response to treatment
US10093981B2 (en) 2010-10-19 2018-10-09 Northwestern University Compositions and methods for identifying depressive disorders
US20150225792A1 (en) 2014-01-17 2015-08-13 Northwestern University Compositions and methods for identifying depressive disorders
GB201017978D0 (en) 2010-10-25 2010-12-08 Oxitec Ltd Multiplex amplification and detection
US20130267443A1 (en) 2010-11-19 2013-10-10 The Regents Of The University Of Michigan ncRNA AND USES THEREOF
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
EP3336200A1 (de) 2010-11-19 2018-06-20 The Regents Of The University Of Michigan Prostatakrebs-ncrna und verwendungen davon
AU2012204467B2 (en) 2011-01-04 2016-08-18 Sillajen, Inc. Generation of antibodies to tumor antigens and generation of tumor specific complement dependent cytotoxicity by administration of oncolytic vaccinia virus
EP2675275B1 (de) 2011-02-14 2017-12-20 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur behandlung von adipositas und damit zusammenhängenden erkrankungen
US8718948B2 (en) 2011-02-24 2014-05-06 Gen-Probe Incorporated Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector
US20140057295A1 (en) 2011-02-28 2014-02-27 Barbara J. Stegmann Anti-mullerian hormone changes in pregnancy and prediction of adverse pregnancy outcomes and gender
CA2829300A1 (en) 2011-03-08 2012-09-13 King Abdullah University Of Science And Technology Molecular biomarker set for early detection of ovarian cancer
WO2012167382A1 (en) 2011-06-08 2012-12-13 Children's Hospital Of Eastern Ontario Research Institute Inc. Compositions and methods for glioblastoma treatment
US10040853B2 (en) 2011-09-09 2018-08-07 Fred Hutchinson Cancer Research Center Methods and compositions involving NKG2D inhibitors and cancer
WO2013044097A1 (en) 2011-09-21 2013-03-28 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
EP3848474A1 (de) 2011-11-04 2021-07-14 Gen-Probe Incorporated Molekulartestreagenzien und -verfahren
US10308980B2 (en) 2011-11-04 2019-06-04 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
WO2013096460A1 (en) 2011-12-20 2013-06-27 The Regents Of The University Of Michigan Pseudogenes and uses thereof
US9334491B2 (en) 2011-12-22 2016-05-10 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids from cellular samples
US9803188B2 (en) 2011-12-22 2017-10-31 Ibis Biosciences, Inc. Systems and methods for isolating nucleic acids
US9970061B2 (en) 2011-12-27 2018-05-15 Ibis Biosciences, Inc. Bioagent detection oligonucleotides
CA2860594A1 (en) 2012-01-09 2013-07-18 Oslo Universitetssykehus Hf Methods and biomarkers for analysis of colorectal cancer
KR101912401B1 (ko) 2012-02-03 2018-10-26 캘리포니아 인스티튜트 오브 테크놀로지 다중화된 생화학적 분석에서의 시그널 인코딩 및 디코딩
CN104220876A (zh) 2012-02-21 2014-12-17 奥斯陆大学医院 用于宫颈癌的检测和预后的方法和生物标志物
EP2823059A2 (de) 2012-03-06 2015-01-14 Oslo Universitetssykehus HF Gensignaturen in zusammenhang mit der wirksamkeit einer postmastektomie-strahlentherapie bei brustkrebs
EP2834370B1 (de) 2012-04-03 2019-01-02 The Regents Of The University Of Michigan Biomarker im zusammenhang mit dem reizdarmsyndrom und morbus crohn
WO2014005076A2 (en) 2012-06-29 2014-01-03 The Regents Of The University Of Michigan Methods and biomarkers for detection of kidney disorders
WO2014022827A1 (en) 2012-08-03 2014-02-06 California Institute Of Technology Multiplexing and quantification in pcr with reduced hardware and requirements
DK3435084T3 (da) 2012-08-16 2023-05-30 Mayo Found Medical Education & Res Prostatakræftprognose under anvendelse af biomarkører
EP2943587A1 (de) * 2013-01-10 2015-11-18 Roche Diagnostics GmbH Verbesserte kalibrierung von hochauflösenden schmelzungen
WO2014116721A1 (en) 2013-01-22 2014-07-31 The Arizona Board Of Regents For And On Behalf Of Arizona State University Geminiviral vector for expression of rituximab
MX377363B (es) 2013-02-21 2025-03-10 Turnstone Lp Composición de vacuna.
CN105378108A (zh) 2013-03-13 2016-03-02 雅培分子公司 用于分离核酸的系统和方法
AU2013202788B2 (en) 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
AU2013202805B2 (en) 2013-03-14 2015-07-16 Gen-Probe Incorporated System and method for extending the capabilities of a diagnostic analyzer
CN105378107A (zh) 2013-03-14 2016-03-02 雅培分子公司 多重甲基化-特异性扩增系统和方法
ES2727898T3 (es) 2013-05-02 2019-10-21 Univ Michigan Regents Amlexanox deuterado con estabilidad metabólica mejorada
JP2016532168A (ja) 2013-05-23 2016-10-13 アイフィノタイプ エルエルシー 表現型を統合したソーシャル検索データベースおよび方法
SG11201602540XA (en) 2013-10-03 2016-04-28 Oklahoma Med Res Found Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US9909181B2 (en) 2013-12-13 2018-03-06 Northwestern University Biomarkers for post-traumatic stress states
EP3151733B1 (de) 2014-06-06 2020-04-15 The Regents Of The University Of Michigan Zusammensetzungen und verfahren zur charakterisierung und diagnose von parodontaler erkrankung
EP3224362B1 (de) 2014-11-26 2024-09-25 The Regents of The University of California Therapeutische zusammensetzungen mit transkriptionsfaktoren sowie verfahren zur herstellung und verwendung davon
WO2016196478A1 (en) 2015-06-01 2016-12-08 St. Jude Children's Research Hospital Methods and compositions for prognostications and/or clinical management of graft-versus-host disease and transplant rejection
CN109526227A (zh) 2016-01-25 2019-03-26 生物辐射欧洲有限公司 数字微生物学
US10214536B2 (en) 2016-01-29 2019-02-26 The Regents Of The University Of Michigan Amlexanox analogs
WO2017173035A1 (en) 2016-04-01 2017-10-05 Chromacode Inc. Competitive probes for engineering signal generation
US10066263B2 (en) 2016-06-17 2018-09-04 California Institute Of Technology Nucleic acid reactions and related methods and compositions
WO2018013509A1 (en) 2016-07-11 2018-01-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for diagnosing and treating arrhythmias
WO2018039490A1 (en) 2016-08-24 2018-03-01 Genomedx Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
WO2018127786A1 (en) 2017-01-06 2018-07-12 Oslo Universitetssykehus Hf Compositions and methods for determining a treatment course of action
EP3571322B9 (de) 2017-01-20 2023-10-04 VERACYTE SD, Inc. Molekulare untertypisierung, prognose und behandlung von blasenkrebs
CA3049778C (en) 2017-01-26 2024-06-18 Oklahoma Medical Research Foundation Biomarkers for systemic lupus erythematosus disease activity, and intensity and flare
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
AU2018266733A1 (en) 2017-05-12 2020-01-16 Veracyte, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
US12140592B2 (en) 2017-06-16 2024-11-12 Oklahoma Medical Research Foundation Biomarkers for assessing risk of transitioning to systemic lupus erythematosus classification and disease pathogenesis
AU2018372906B2 (en) 2017-11-22 2025-04-03 The Regents Of The University Of Michigan Compositions and methods for treating cancer
EP3781710A4 (de) 2018-04-17 2022-01-05 Chromacode, Inc. Verfahren und systeme zur multiplex-analyse
BR112020021218A2 (pt) 2018-04-18 2021-03-02 St. Jude Children's Research Hospital ensaios de genotipagem para identificar mutações em xaf1
EP3788377A1 (de) 2018-05-04 2021-03-10 Abbott Laboratories Hbv-diagnostische, prognostische und therapeutische verfahren und produkte
US12203129B2 (en) 2018-07-03 2025-01-21 ChromaCode, Inc. Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays
WO2020081204A1 (en) 2018-10-18 2020-04-23 Oklahoma Medical Research Foundation Biomarkers for a systemic lupus erythematosus (sle) disease activity immune index that characterizes disease activity
AU2019371161A1 (en) 2018-10-31 2021-06-17 Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers and methods of use for radiation-induced lung injury
US12139764B2 (en) 2018-11-14 2024-11-12 Arizona Board Of Regents On Behalf Of The University Of Arizona Systems and methods for characterizing and treating breast cancer
US20220296622A1 (en) 2019-09-16 2022-09-22 The Children's Hospital Of Philadelphia Compositions and methods for the treatment of swi-snf mutant tumors
WO2023021330A1 (en) 2021-08-16 2023-02-23 University Of Oslo Compositions and methods for determining a treatment course of action
WO2023023673A2 (en) 2021-08-20 2023-02-23 Kasa Bio, L.L.C. Compositions and methods for multiplex detection of mirna and other polynucelotides

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4407942A (en) * 1981-01-29 1983-10-04 Atomic Energy Of Canada Limited Fluorescent detection of DNA damage
US4562159A (en) * 1981-03-31 1985-12-31 Albert Einstein College Of Medicine, A Division Of Yeshiva Univ. Diagnostic test for hepatitis B virus
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
GB8311905D0 (en) * 1983-04-29 1983-06-02 Cox R A Isolation and detection of nucleotide sequence
US4626501A (en) * 1983-09-02 1986-12-02 Integrated Genetics, Inc. Labeled DNA
JPS60166695A (ja) * 1984-02-09 1985-08-29 Wakunaga Seiyaku Kk オリゴヌクレオチド誘導体およびその製造法
CA1254114A (en) * 1984-05-07 1989-05-16 Allied Corporation Displacement polynucleotide assay employing recombination protein and diagnostic kit
US4670379A (en) * 1984-12-19 1987-06-02 E. I. Du Pont De Nemours And Company Polynucleotide hydridization assays employing catalyzed luminescence
CA1273552A (en) * 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
US4868103A (en) * 1986-02-19 1989-09-19 Enzo Biochem, Inc. Analyte detection by means of energy transfer

Also Published As

Publication number Publication date
EP0232967A3 (en) 1989-05-24
JPS62244399A (ja) 1987-10-24
EP0232967B1 (de) 1993-04-28
EP0232967A2 (de) 1987-08-19
DE3785591T2 (de) 1993-09-02
DE3785591D1 (de) 1993-06-03
US5928862A (en) 1999-07-27
JP2619866B2 (ja) 1997-06-11
CA1296242C (en) 1992-02-25

Similar Documents

Publication Publication Date Title
ATE88761T1 (de) Kompetitiver homogener test.
DE68901285D1 (de) Verfahren zum nachweis von nukleotid-sequenzen.
FI911536A7 (fi) Nukleiinihappokoettimet, jotka sisältävät parannetun molekyylikytkimen , sekä niitä sisältävät määritysmenetelmät ja testipakkaukset
DE3480487D1 (en) Nucleic acid hybridization assay
EP0139489A3 (de) Sandwichhybridisierungsverfahren zum Nachweis von Nukleinsäuren
DE3586659D1 (de) Hybridizierungstest fuer nukleinsaeure.
CA2118913A1 (en) Nucleic acids extension assay
SE8600011D0 (sv) Metod for identifiering av nukleinsyror
ATE65092T1 (de) Verstaerkung von hybridisierungssignalen durch verwendung von komplementarischen dns-straengen.
DE68913086D1 (de) Qualitativer Enzymtest zur visuellen Auswertung.
ATE123577T1 (de) Vaginale probe, test und reagenzien.
ATE82773T1 (de) Diagnostischer test unter verwendung von nucleinsaeure-sonden.
EP0305145A3 (de) Verfahren und Sonden zur Bestimmung von Nukleinsäuren
EP0237833A3 (de) Flüssigphase-Hybridizierungstest zum Nachweis von Polynukleotid-Sequenzen
DE69529691D1 (de) Differenziertes timingsverfahren zum nachweiss multiple analyte in eine testprobe
GB9119650D0 (en) Homogeneous nucleic acids probe-based test & substances
EP0194789A3 (de) Apparat und Verfahren für mehrfache gleichzeitige Untersuchung
IT1207783B (it) Cestello rotante per macchine lavabiancheria con un motore elettrico coassiale.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties