IL104461A - Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them - Google Patents

Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them

Info

Publication number
IL104461A
IL104461A IL10446193A IL10446193A IL104461A IL 104461 A IL104461 A IL 104461A IL 10446193 A IL10446193 A IL 10446193A IL 10446193 A IL10446193 A IL 10446193A IL 104461 A IL104461 A IL 104461A
Authority
IL
Israel
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
oligonucleotide analogs
oligonucleotide
Prior art date
Application number
IL10446193A
Other versions
IL104461D0 (en
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE4201662 priority Critical
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of IL104461D0 publication Critical patent/IL104461D0/en
Publication of IL104461A publication Critical patent/IL104461A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11Compounds covalently bound to a solid support
IL10446193A 1992-01-22 1993-01-20 Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them IL104461A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE4201662 1992-01-22

Publications (2)

Publication Number Publication Date
IL104461D0 IL104461D0 (en) 1993-05-13
IL104461A true IL104461A (en) 2001-05-20

Family

ID=6450030

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10446193A IL104461A (en) 1992-01-22 1993-01-20 Oligonucleotide analogs, their preparation and pharmaceutical compositions containing them

Country Status (16)

Country Link
EP (1) EP0552766B1 (en)
JP (1) JP3717081B2 (en)
AT (1) AT217880T (en)
AU (1) AU661365B2 (en)
CA (1) CA2087818C (en)
DE (1) DE59310285D1 (en)
DK (1) DK0552766T3 (en)
ES (1) ES2177532T3 (en)
FI (1) FI115214B (en)
HU (1) HU227794B1 (en)
IL (1) IL104461A (en)
NO (1) NO308215B1 (en)
NZ (1) NZ245720A (en)
PL (1) PL172257B1 (en)
PT (1) PT552766E (en)
ZA (1) ZA9300422B (en)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378825A (en) * 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
DE59306170D1 (en) * 1992-09-24 1997-05-22 Hoechst Ag Oligoribonucleotid- and ribozyme analogues with terminal 3'-3'-bzw.5'-5 'linkages
EP0602524A1 (en) * 1992-12-15 1994-06-22 Hoechst Aktiengesellschaft Chemiluminescence marked sequences and their use in sequence testing
AT150464T (en) * 1993-01-08 1997-04-15 Hybridon Inc Synthesis of dimer-blocks and their use in the composition of oligonucleotides
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
AT138384T (en) * 1993-01-25 1996-06-15 Hybridon Inc Olionukleotidalkylphosphonate and - phosphonothioate
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US5532130A (en) * 1993-07-20 1996-07-02 Dyad Pharmaceutical Corporation Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
DE4331670A1 (en) * 1993-09-17 1995-03-23 Hoechst Ag Antisense oligonucleotides against HSV-1 and the preparation thereof
DE4338704A1 (en) 1993-11-12 1995-05-18 Hoechst Ag Stabilized oligonucleotides and their use
US6919441B2 (en) 1994-03-14 2005-07-19 Aventis Pharma Deutschland Gmbh Polyamide-oligonucleotide derivatives, their preparation and use
DE4408528A1 (en) * 1994-03-14 1995-09-28 Hoechst Ag Peptide-oligonucleotide derivatives, their preparation and use
US5726297A (en) * 1994-03-18 1998-03-10 Lynx Therapeutics, Inc. Oligodeoxyribonucleotide N3' P5' phosphoramidates
US5599922A (en) * 1994-03-18 1997-02-04 Lynx Therapeutics, Inc. Oligonucleotide N3'-P5' phosphoramidates: hybridization and nuclease resistance properties
JP3482209B2 (en) * 1994-03-18 2003-12-22 ジェロン・コーポレーション Oligonucleotides n3 '→ p5' phosphoramidate Synthesis and compounds; hybridization and nuclease resistance properties
DE4415370A1 (en) * 1994-05-02 1995-11-09 Hoechst Ag Modified oligonucleotides, their preparation and their use
US5986076A (en) * 1994-05-11 1999-11-16 Trustees Of Boston University Photocleavable agents and conjugates for the detection and isolation of biomolecules
US5696248A (en) * 1994-06-15 1997-12-09 Hoechst Aktiengesellschaft 3'-modified oligonucleotide derivatives
US6326487B1 (en) 1995-06-05 2001-12-04 Aventis Pharma Deutschland Gmbh 3 modified oligonucleotide derivatives
DE4438918A1 (en) * 1994-11-04 1996-05-09 Hoechst Ag Modified oligonucleotides, their preparation and their use
US6150510A (en) * 1995-11-06 2000-11-21 Aventis Pharma Deutschland Gmbh Modified oligonucleotides, their preparation and their use
DE19502912A1 (en) 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilized oligonucleotides
ES2165446T3 (en) * 1995-03-13 2002-03-16 Aventis Pharma Gmbh Fosfonomonoester-nucleic acids, process for their preparation and their use.
US5859233A (en) * 1996-02-21 1999-01-12 Lynx Therapeutics, Inc. Synthons for synthesis of oligonucleotide N3-P5 phosphoramidates
US5684143A (en) * 1996-02-21 1997-11-04 Lynx Therapeutics, Inc. Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
GB9606158D0 (en) * 1996-03-23 1996-05-29 Ciba Geigy Ag Chemical compounds
DE69729145D1 (en) * 1996-05-24 2004-06-24 Aventis Pharma Gmbh Reagent and method for inhibition of N-RAS Expression
DE19627898A1 (en) * 1996-07-11 1998-01-15 Hoechst Ag Solid phase synthesis of oligonucleotides
CN1304572C (en) * 1997-05-05 2007-03-14 萨诺费-阿文蒂斯德国有限公司 Modified antisense nucleotides complementary to section of human Ha-Ras gene
WO1999019474A1 (en) * 1997-10-14 1999-04-22 Sankyo Company, Limited Modified oligodeoxyribonucleotides having tggg sequence
EP1004661A1 (en) 1998-11-11 2000-05-31 DALLI-WERKE WÄSCHE- und KÖRPERPFLEGE GmbH & Co. KG High density granule, method for production thereof, and its use as disintegrant in tablets
DE19935302A1 (en) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Conjugates and methods for their preparation and their use for the transport of molecules across biological membranes
DE19935303A1 (en) 1999-07-28 2001-02-08 Aventis Pharma Gmbh Oligonucleotides for inhibiting the expression of human Eg5
DE10133915A1 (en) 2001-07-12 2003-02-06 Aventis Pharma Gmbh New oligoribonucleotide derivatives for targeted inhibition of gene expression
EP2338995A3 (en) 2003-08-28 2012-01-11 Novartis AG Interfering RNA duplex having blunt-ends and 3'-modifications
GB0608838D0 (en) 2006-05-04 2006-06-14 Novartis Ag Organic compounds
CN104975020A (en) 2008-02-11 2015-10-14 阿克赛医药公司 Modified Rnai Polynucleotides And Uses Thereof
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
JP2012502991A (en) 2008-09-22 2012-02-02 アールエックスアイ ファーマシューティカルズ コーポレーション rna interference in the skin applied
WO2010059226A2 (en) 2008-11-19 2010-05-27 Rxi Pharmaceuticals Corporation Inhibition of map4k4 through rnai
US9745574B2 (en) 2009-02-04 2017-08-29 Rxi Pharmaceuticals Corporation RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
CN103200945B (en) 2010-03-24 2016-07-06 雷克西制药公司 rna interference in ocular symptoms
RU2615143C2 (en) 2010-03-24 2017-04-04 Адвирна Self-delivered rnai compounds of reduced size
US9340786B2 (en) 2010-03-24 2016-05-17 Rxi Pharmaceuticals Corporation RNA interference in dermal and fibrotic indications
WO2015125845A1 (en) * 2014-02-20 2015-08-27 塩野義製薬株式会社 Phosphate site modification of nucleic acid containing nitrogen-containing non-aromatic heterocycle

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3239888A1 (en) * 1982-10-28 1984-05-03 Hubert Prof Dr Koester A process for preparing oligonucleosidphosphonaten
US4739044A (en) * 1985-06-13 1988-04-19 Amgen Method for derivitization of polynucleotides
WO1988003149A1 (en) * 1986-10-30 1988-05-05 Daicel Chemical Industries, Ltd. Process for synthesizing oligonucleotides and compounds for forming high-molecular protective group
US4816571A (en) * 1987-06-04 1989-03-28 Applied Biosystems, Inc. Chemical capping by phosphitylation during oligonucleotide synthesis
CA2071510C (en) * 1989-10-24 2004-07-06 Chris A. Buhr 2' modified oligonucleotides
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
GB9021625D0 (en) * 1990-10-04 1990-11-21 Ici Plc Synthesis of oligonucleotides

Also Published As

Publication number Publication date
EP0552766A2 (en) 1993-07-28
PT552766E (en) 2002-10-31
FI930220A (en) 1993-07-23
DK0552766T3 (en) 2002-08-19
AU661365B2 (en) 1995-07-20
FI115214B (en) 2005-03-31
EP0552766A3 (en) 1994-09-07
HU227794B1 (en) 2012-03-28
NZ245720A (en) 1995-12-21
CA2087818C (en) 2007-07-10
NO930199L (en) 1993-07-23
PL172257B1 (en) 1997-08-29
FI115214B1 (en)
NO308215B1 (en) 2000-08-14
HUT63173A (en) 1993-07-28
JPH05310779A (en) 1993-11-22
NO930199D0 (en) 1993-01-21
HU9300162D0 (en) 1993-04-28
AT217880T (en) 2002-06-15
AU3191093A (en) 1993-07-29
FI930220D0 (en)
ES2177532T3 (en) 2002-12-16
CA2087818A1 (en) 1993-07-23
DE59310285D1 (en) 2002-06-27
EP0552766B1 (en) 2002-05-22
FI930220A0 (en) 1993-01-20
PL297515A1 (en) 1993-09-06
IL104461D0 (en) 1993-05-13
ZA9300422B (en) 1993-09-16
JP3717081B2 (en) 2005-11-16

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