WO1989010758A1
(en)
*
|
1988-05-02 |
1989-11-16 |
Zynaxis Technologies, Inc. |
Compounds, compositions and method for binding bio-affecting substances to surface membranes of bio-particles
|
US6867195B1
(en)
|
1989-03-21 |
2005-03-15 |
Vical Incorporated |
Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
|
DE69034078T2
(de)
*
|
1989-03-21 |
2004-04-01 |
Vical, Inc., San Diego |
Expression von exogenen Polynukleotidsequenzen in Wirbeltieren
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
US6214804B1
(en)
|
1989-03-21 |
2001-04-10 |
Vical Incorporated |
Induction of a protective immune response in a mammal by injecting a DNA sequence
|
US6706694B1
(en)
|
1990-03-21 |
2004-03-16 |
Vical Incorporated |
Expression of exogenous polynucleotide sequences in a vertebrate
|
US6228844B1
(en)
|
1991-11-12 |
2001-05-08 |
Vical Incorporated |
Stimulating vascular growth by administration of DNA sequences encoding VEGF
|
US5543389A
(en)
*
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University, A Non Profit Organization |
Covalent polar lipid-peptide conjugates for use in salves
|
US5827819A
(en)
*
|
1990-11-01 |
1998-10-27 |
Oregon Health Sciences University |
Covalent polar lipid conjugates with neurologically active compounds for targeting
|
US5256641A
(en)
*
|
1990-11-01 |
1993-10-26 |
State Of Oregon |
Covalent polar lipid-peptide conjugates for immunological targeting
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
US6605712B1
(en)
*
|
1990-12-20 |
2003-08-12 |
Arch Development Corporation |
Gene transcription and ionizing radiation: methods and compositions
|
US6156304A
(en)
*
|
1990-12-20 |
2000-12-05 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Gene transfer for studying and treating a connective tissue of a mammalian host
|
US20020123476A1
(en)
*
|
1991-03-19 |
2002-09-05 |
Emanuele R. Martin |
Therapeutic delivery compositions and methods of use thereof
|
US7202225B1
(en)
*
|
1993-10-15 |
2007-04-10 |
Emanuele R Martin |
Therapeutic delivery compositions and methods of use thereof
|
US5693769A
(en)
*
|
1991-12-13 |
1997-12-02 |
Transcell Technologies, Inc. |
Glycosylated steroid derivatives for transport across biological membranes and process for making and using same
|
US5795870A
(en)
*
|
1991-12-13 |
1998-08-18 |
Trustees Of Princeton University |
Compositions and methods for cell transformation
|
WO1993012240A1
(en)
|
1991-12-17 |
1993-06-24 |
The Regents Of The University Of California |
Gene therapy for cystic fibrosis transmembrane conductance regulator activity (cftr)
|
US5756353A
(en)
*
|
1991-12-17 |
1998-05-26 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol-and liposome-based delivery
|
US5858784A
(en)
*
|
1991-12-17 |
1999-01-12 |
The Regents Of The University Of California |
Expression of cloned genes in the lung by aerosol- and liposome-based delivery
|
US6627615B1
(en)
|
1991-12-17 |
2003-09-30 |
The Regents Of The University Of California |
Methods and compositions for in vivo gene therapy
|
EP0625049A4
(en)
*
|
1992-01-23 |
1995-07-12 |
Vical Inc |
EX VIVO GENTRANSFER.
|
US5885970A
(en)
*
|
1992-03-16 |
1999-03-23 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides against human protein kinase C
|
US6113946A
(en)
*
|
1992-04-03 |
2000-09-05 |
The Regents Of The University Of California |
Self-assembling polynucleotide delivery system comprising dendrimer polycations
|
CA2133323C
(en)
*
|
1992-04-03 |
2010-10-26 |
Francis C. Szoka, Jr. |
Self-assembling polynucleotide delivery system
|
US5792751A
(en)
*
|
1992-04-13 |
1998-08-11 |
Baylor College Of Medicine |
Tranformation of cells associated with fluid spaces
|
US20020108136A1
(en)
*
|
1997-03-21 |
2002-08-08 |
Sri |
Transgenic animals produced by homologous sequence targeting
|
US6806084B1
(en)
*
|
1992-06-04 |
2004-10-19 |
The Regents Of The University Of California |
Methods for compositions for in vivo gene delivery
|
AU4528493A
(en)
*
|
1992-06-04 |
1994-01-04 |
Regents Of The University Of California, The |
In vivo gene therapy with intron-free sequence of interest
|
WO1994001131A1
(en)
*
|
1992-07-13 |
1994-01-20 |
Eukarion, Inc. |
Transvascular and intracellular delivery of lipidized proteins
|
US7105574B1
(en)
|
1999-03-26 |
2006-09-12 |
Vical Incorporated |
Adjuvant compositions and methods for enhancing immune responses to polynucleotide-based vaccines
|
US5334761A
(en)
*
|
1992-08-28 |
1994-08-02 |
Life Technologies, Inc. |
Cationic lipids
|
IL107150A0
(en)
*
|
1992-09-29 |
1993-12-28 |
Isis Pharmaceuticals Inc |
Oligonucleotides having a conserved g4 core sequence
|
US5329029A
(en)
*
|
1992-11-05 |
1994-07-12 |
Wan Barbara Y |
Phosphatidylalkanolamine derivatives and their use in generating phospholipid conjugates
|
US5552155A
(en)
*
|
1992-12-04 |
1996-09-03 |
The Liposome Company, Inc. |
Fusogenic lipsomes and methods for making and using same
|
US5705655A
(en)
*
|
1992-12-17 |
1998-01-06 |
Megabios Corporation |
Amphiphilic nitrogen containing imidazolinium derivative compounds and uses
|
US5631237A
(en)
*
|
1992-12-22 |
1997-05-20 |
Dzau; Victor J. |
Method for producing in vivo delivery of therapeutic agents via liposomes
|
US5578709A
(en)
*
|
1993-03-09 |
1996-11-26 |
Middlesex Sciences, Inc. |
Macromolecular microparticles and methods of production
|
US6090925A
(en)
|
1993-03-09 |
2000-07-18 |
Epic Therapeutics, Inc. |
Macromolecular microparticles and methods of production and use
|
JPH09500013A
(ja)
*
|
1993-06-01 |
1997-01-07 |
ライフ・テクノロジーズ・インコーポレイテッド |
カチオン性脂質による遺伝子免疫
|
WO1995002698A1
(en)
*
|
1993-07-12 |
1995-01-26 |
Life Technologies, Inc. |
Composition and methods for transfecting eukaryotic cells
|
US5563111A
(en)
*
|
1993-08-03 |
1996-10-08 |
Kao Corporation |
Agricultural chemical composition comprising amine surfactants with at least one ester or amide linkage
|
US6348449B1
(en)
|
1993-09-21 |
2002-02-19 |
The Trustees Of The University Of Pennsylvania |
Methods of inducing mucosal immunity
|
NZ276975A
(en)
*
|
1993-11-24 |
1998-04-27 |
Megabios Corp |
Guanidine based amphiphiles and their use in liposomes for delivering genetic material intracellularly
|
US5665879A
(en)
*
|
1993-11-24 |
1997-09-09 |
Megabios Corporation |
Amphiphilic derivatives of piperazine
|
KR960705798A
(ko)
*
|
1993-11-24 |
1996-11-08 |
벤자민 에프 맥그로우 |
피페라진의 양쪽친화성 유도체(amphiphilic derivatives of piperazine)
|
US6613351B1
(en)
*
|
1993-12-20 |
2003-09-02 |
Biotech Tools S.A. |
Compound capable of introducing at least one molecule into a cell
|
US5674908A
(en)
|
1993-12-20 |
1997-10-07 |
Life Technologies, Inc. |
Highly packed polycationic ammonium, sulfonium and phosphonium lipids
|
US6057299A
(en)
*
|
1994-01-13 |
2000-05-02 |
Calydon, Inc. |
Tissue-specific enhancer active in prostate
|
US5830686A
(en)
*
|
1994-01-13 |
1998-11-03 |
Calydon |
Tissue-specific enhancer active in prostate
|
US5928944A
(en)
*
|
1994-02-04 |
1999-07-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Method of adenoviral-medicated cell transfection
|
US6075012A
(en)
*
|
1994-02-11 |
2000-06-13 |
Life Technologies, Inc. |
Reagents for intracellular delivery of macromolecules
|
US6989434B1
(en)
|
1994-02-11 |
2006-01-24 |
Invitrogen Corporation |
Reagents for intracellular delivery of macromolecules
|
US6074840A
(en)
|
1994-02-18 |
2000-06-13 |
The Regents Of The University Of Michigan |
Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
|
US5942496A
(en)
|
1994-02-18 |
1999-08-24 |
The Regent Of The University Of Michigan |
Methods and compositions for multiple gene transfer into bone cells
|
US5962427A
(en)
|
1994-02-18 |
1999-10-05 |
The Regent Of The University Of Michigan |
In vivo gene transfer methods for wound healing
|
US5763416A
(en)
|
1994-02-18 |
1998-06-09 |
The Regent Of The University Of Michigan |
Gene transfer into bone cells and tissues
|
US6995008B1
(en)
|
1994-03-07 |
2006-02-07 |
Merck & Co., Inc. |
Coordinate in vivo gene expression
|
US6551618B2
(en)
|
1994-03-15 |
2003-04-22 |
University Of Birmingham |
Compositions and methods for delivery of agents for neuronal regeneration and survival
|
US5651981A
(en)
*
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
US5739118A
(en)
|
1994-04-01 |
1998-04-14 |
Apollon, Inc. |
Compositions and methods for delivery of genetic material
|
WO1995027496A1
(en)
*
|
1994-04-07 |
1995-10-19 |
Proteinix Company |
Vasoactive intestinal polypeptide
|
WO1995031183A1
(en)
*
|
1994-05-16 |
1995-11-23 |
Washington University |
Cell membrane fusion composition and method
|
WO1995035301A1
(en)
*
|
1994-06-22 |
1995-12-28 |
Megabios Corporation |
Cationic amphiphiles
|
US5777153A
(en)
*
|
1994-07-08 |
1998-07-07 |
Gilead Sciences, Inc. |
Cationic lipids
|
FR2722506B1
(fr)
*
|
1994-07-13 |
1996-08-14 |
Rhone Poulenc Rorer Sa |
Composition contenant des acides nucleiques, preparation et utilisations
|
DE4426429A1
(de)
*
|
1994-07-26 |
1996-02-01 |
Boehringer Ingelheim Int |
Verfahren zum Einführen von DNA in höhere eukaryotische Zellen
|
US7592317B1
(en)
*
|
1994-08-11 |
2009-09-22 |
The University Of Chicago |
Constitutive gene expression in conjuction with ionizing radiation
|
AUPM747694A0
(en)
*
|
1994-08-16 |
1994-09-08 |
Commonwealth Scientific And Industrial Research Organisation |
Delivery of nucleic acids and peptides
|
US5892071A
(en)
*
|
1994-09-30 |
1999-04-06 |
The Reagents Of The University Of California |
Cationic transport reagents
|
US5527928A
(en)
*
|
1994-09-30 |
1996-06-18 |
Nantz; Michael H. |
Cationic transport reagents
|
US5837533A
(en)
*
|
1994-09-28 |
1998-11-17 |
American Home Products Corporation |
Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent
|
EP1179340A3
(en)
*
|
1994-09-30 |
2003-05-07 |
INEX Pharmaceutical Corp. |
Compositions for the introduction of polyanionic materials into cells
|
US5753613A
(en)
*
|
1994-09-30 |
1998-05-19 |
Inex Pharmaceuticals Corporation |
Compositions for the introduction of polyanionic materials into cells
|
US6911216B1
(en)
|
1994-10-12 |
2005-06-28 |
Genzyme Corporation |
Targeted delivery via biodegradable polymers
|
US5641665A
(en)
|
1994-11-28 |
1997-06-24 |
Vical Incorporated |
Plasmids suitable for IL-2 expression
|
US5767099A
(en)
*
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
US5650096A
(en)
*
|
1994-12-09 |
1997-07-22 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
US5747471A
(en)
*
|
1994-12-09 |
1998-05-05 |
Genzyme Corporation |
Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules
|
US5910487A
(en)
*
|
1994-12-09 |
1999-06-08 |
Genzyme Corporation |
Cationic amphiphiles and plasmids for intracellular delivery of therapeutic molecules
|
US5939401A
(en)
*
|
1994-12-09 |
1999-08-17 |
Genzyme Corporation |
Cationic amphiphile compositions for intracellular delivery of therapeutic molecules
|
US5719131A
(en)
*
|
1994-12-09 |
1998-02-17 |
Genzyme Corporation |
Cationic amphiphiles containing dialkylamine lipophilic groups for intracellular delivery of therapeutic molecules
|
US5840710A
(en)
*
|
1994-12-09 |
1998-11-24 |
Genzyme Corporation |
Cationic amphiphiles containing ester or ether-linked lipophilic groups for intracellular delivery of therapeutic molecules
|
US5948767A
(en)
*
|
1994-12-09 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphile/DNA complexes
|
US6331524B1
(en)
|
1994-12-09 |
2001-12-18 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile / DNA complexes for gene therapy
|
US6383814B1
(en)
|
1994-12-09 |
2002-05-07 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
US6071890A
(en)
*
|
1994-12-09 |
2000-06-06 |
Genzyme Corporation |
Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy
|
US6630455B1
(en)
|
1995-01-13 |
2003-10-07 |
Vanderbilt University |
Methods for inducing mucosal immune responses
|
US5795587A
(en)
|
1995-01-23 |
1998-08-18 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
US6008202A
(en)
*
|
1995-01-23 |
1999-12-28 |
University Of Pittsburgh |
Stable lipid-comprising drug delivery complexes and methods for their production
|
US5929043A
(en)
*
|
1995-01-31 |
1999-07-27 |
Pangene Corporation |
Recombinase mediated DNA therapies
|
US5830430A
(en)
*
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
US20030148968A1
(en)
*
|
1995-02-28 |
2003-08-07 |
Hammond H. Kirk |
Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
|
US6752987B1
(en)
|
1995-02-28 |
2004-06-22 |
The Regents Of The University Of California |
Adenovirus encoding human adenylylcyclase (AC) VI
|
EP0760682A4
(en)
|
1995-02-28 |
1998-09-09 |
Univ California |
ANGIOGENIC THERAPY BY GENE TRANSFER
|
US5962428A
(en)
*
|
1995-03-30 |
1999-10-05 |
Apollon, Inc. |
Compositions and methods for delivery of genetic material
|
US20020183288A1
(en)
*
|
1995-04-03 |
2002-12-05 |
Bone Care International, Inc. |
Method for treating and preventing hyperparathyroidism
|
US6242434B1
(en)
*
|
1997-08-08 |
2001-06-05 |
Bone Care International, Inc. |
24-hydroxyvitamin D, analogs and uses thereof
|
US20040043971A1
(en)
*
|
1995-04-03 |
2004-03-04 |
Bone Care International, Inc. |
Method of treating and preventing hyperparathyroidism with active vitamin D analogs
|
EP0826063A1
(en)
*
|
1995-04-25 |
1998-03-04 |
Vical Incorporated |
Single-vial formulations of dna/lipid complexes
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
US5711964A
(en)
*
|
1995-06-07 |
1998-01-27 |
United States Of America |
Method for the intracellular delivery of biomolecules using liposomes containing cationic lipids and vitamin D
|
US5705385A
(en)
*
|
1995-06-07 |
1998-01-06 |
Inex Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
US5759519A
(en)
*
|
1995-06-07 |
1998-06-02 |
Gen-Probe Incorporated |
Method for the intracellular delivery of biomolecules using thiocationic lipids
|
US20030069173A1
(en)
*
|
1998-03-16 |
2003-04-10 |
Life Technologies, Inc. |
Peptide-enhanced transfections
|
US5739271A
(en)
*
|
1995-06-07 |
1998-04-14 |
Gen-Probe Incorporated |
Thiocationic lipids
|
CA2222586A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Gen-Probe Incorporated |
Thiocationic lipids, pharmaceutical compositions and methods of use thereof
|
US5869040A
(en)
*
|
1995-06-07 |
1999-02-09 |
Biogen, Inc |
Gene therapy methods and compositions
|
US7422902B1
(en)
|
1995-06-07 |
2008-09-09 |
The University Of British Columbia |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
AU5979296A
(en)
*
|
1995-06-07 |
1996-12-30 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
US5756352A
(en)
*
|
1995-06-07 |
1998-05-26 |
Gen-Probe Incorporated |
Thiocationic lipid-nucleic acid conjugates
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
US6051429A
(en)
|
1995-06-07 |
2000-04-18 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
US5851548A
(en)
*
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
US5994315A
(en)
*
|
1995-06-07 |
1999-11-30 |
East Carolina University |
Low adenosine agent, composition, kit and method for treatment of airway disease
|
EP0830368A1
(en)
|
1995-06-07 |
1998-03-25 |
Genta Incorporated |
Novel carbamate-based cationic lipids
|
CA2223179A1
(en)
*
|
1995-06-07 |
1996-12-19 |
Bob Dale Brown |
Phosphonic acid-based cationic lipids
|
IL122290A0
(en)
*
|
1995-06-07 |
1998-04-05 |
Inex Pharmaceuticals Corp |
Lipid-nucleic acid complex its preparation and use
|
DE19521412A1
(de)
*
|
1995-06-14 |
1996-12-19 |
Boehringer Mannheim Gmbh |
Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung
|
US5931809A
(en)
*
|
1995-07-14 |
1999-08-03 |
Depotech Corporation |
Epidural administration of therapeutic compounds with sustained rate of release
|
US6339173B1
(en)
|
1996-07-22 |
2002-01-15 |
Promega Biosciences, Inc. |
Amide-based cationic lipids
|
WO1997003939A1
(en)
*
|
1995-07-21 |
1997-02-06 |
Genta Incorporated |
Novel amide-based cationic lipids
|
US5855911A
(en)
*
|
1995-08-29 |
1999-01-05 |
Board Of Regents, The University Of Texas System |
Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides
|
NO953680D0
(no)
*
|
1995-09-18 |
1995-09-18 |
Hans Prydz |
Cellesyklusenzymer
|
US6120794A
(en)
|
1995-09-26 |
2000-09-19 |
University Of Pittsburgh |
Emulsion and micellar formulations for the delivery of biologically active substances to cells
|
AU7078396A
(en)
*
|
1995-09-27 |
1997-04-30 |
Regents Of The University Of California, The |
Polyfunctional cationic cytofectins, formulations and methods for generating active cytofectin:polynucleotide transfection complexes
|
US5869715A
(en)
*
|
1995-09-27 |
1999-02-09 |
The Reagents Of The University Of California |
Polyfunctional cationic cytofectins
|
US6086913A
(en)
*
|
1995-11-01 |
2000-07-11 |
University Of British Columbia |
Liposomal delivery of AAV vectors
|
CA2237316C
(en)
*
|
1995-11-30 |
2012-06-26 |
Vical Incorporated |
Complex cationic lipids
|
US6537776B1
(en)
|
1999-06-14 |
2003-03-25 |
Diversa Corporation |
Synthetic ligation reassembly in directed evolution
|
US6126964A
(en)
*
|
1996-01-04 |
2000-10-03 |
Mirus Corporation |
Process of making a compound by forming a polymer from a template drug
|
AUPN741696A0
(en)
*
|
1996-01-05 |
1996-01-25 |
Commonwealth Scientific And Industrial Research Organisation |
Delivery of nucleic acids ii
|
US7002027B1
(en)
*
|
1996-01-08 |
2006-02-21 |
Canji, Inc. |
Compositions and methods for therapeutic use
|
US6392069B2
(en)
*
|
1996-01-08 |
2002-05-21 |
Canji, Inc. |
Compositions for enhancing delivery of nucleic acids to cells
|
US5789244A
(en)
*
|
1996-01-08 |
1998-08-04 |
Canji, Inc. |
Compositions and methods for the treatment of cancer using recombinant viral vector delivery systems
|
US20040014709A1
(en)
*
|
1996-01-08 |
2004-01-22 |
Canji, Inc. |
Methods and compositions for interferon therapy
|
JP4512882B2
(ja)
*
|
1996-02-09 |
2010-07-28 |
チェング ピー―ワン |
受容体リガンドにより促進される生物活性分子の送達
|
US5783566A
(en)
*
|
1996-05-10 |
1998-07-21 |
California Institute Of Technology |
Method for increasing or decreasing transfection efficiency
|
AU2214597A
(en)
*
|
1996-03-18 |
1997-10-10 |
California Institute Of Technology |
Methods for increasing or decreasing transfection efficiency
|
US5994317A
(en)
*
|
1996-04-09 |
1999-11-30 |
Vical Incorporated |
Quaternary cytofectins
|
US5798250A
(en)
*
|
1996-04-15 |
1998-08-25 |
Icn Pharmaceuticals, Inc. |
Facilitating hepatitus virus infection in cell culture using a membrane stressor
|
DE69736981D1
(de)
*
|
1996-05-01 |
2007-01-04 |
Imarx Pharmaceutical Corp |
In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
|
HUP9901790A3
(en)
*
|
1996-05-08 |
2010-11-29 |
Nika Health Products Ltd |
Cationic virosomes as transfer system for genetic material
|
WO1997042819A1
(en)
*
|
1996-05-13 |
1997-11-20 |
Alberto Haces |
Cationic lipids for transfection of negatively charged or neutral molecules into living cells
|
US5980935A
(en)
*
|
1996-05-15 |
1999-11-09 |
Kirpotin; Dmitri |
Cationic lipids and methods of use therefor
|
US8323963B2
(en)
*
|
1996-05-29 |
2012-12-04 |
University Of Southern California |
Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
|
US6274136B1
(en)
*
|
1996-05-29 |
2001-08-14 |
University Of Southern California |
Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
|
US5935936A
(en)
*
|
1996-06-03 |
1999-08-10 |
Genzyme Corporation |
Compositions comprising cationic amphiphiles and co-lipids for intracellular delivery of therapeutic molecules
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
US6093816A
(en)
*
|
1996-06-27 |
2000-07-25 |
Isis Pharmaceuticals, Inc. |
Cationic lipids
|
AU3514197A
(en)
*
|
1996-07-03 |
1998-01-21 |
Genetics Institute Inc. |
Protease fmh-1, an ice/ced-like protease
|
JPH11514009A
(ja)
*
|
1996-07-23 |
1999-11-30 |
オレゴン ヘルス サイエンスィズ ユニヴァースティ |
軟膏において用いるための、生物学的に活性の成分との共有結合極性脂質結合体
|
US7384923B2
(en)
*
|
1999-05-14 |
2008-06-10 |
Lipoxen Technologies Limited |
Liposomes
|
ES2305157T3
(es)
*
|
1996-09-13 |
2008-11-01 |
Lipoxen Technologies Limited |
Liposomas.
|
SG94355A1
(en)
|
1996-10-01 |
2003-02-18 |
Geron Corp |
Human telomerase catalytic subunit
|
US5861397A
(en)
*
|
1996-10-03 |
1999-01-19 |
Vical Incorporated |
Piperazine based cytofectins
|
US6977244B2
(en)
|
1996-10-04 |
2005-12-20 |
Board Of Regents, The University Of Texas Systems |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
FR2754828B1
(fr)
*
|
1996-10-23 |
1998-12-24 |
Univ Toulouse |
Structure membranaire artificielle, procede et polymere pour sa preparation, procede de preparation de ce polymere, particule et film comprenant cette structure
|
US6210707B1
(en)
|
1996-11-12 |
2001-04-03 |
The Regents Of The University Of California |
Methods of forming protein-linked lipidic microparticles, and compositions thereof
|
US6071533A
(en)
*
|
1996-11-12 |
2000-06-06 |
The Regents Of The University Of California |
Preparation of stable formulations of lipid-nucleic acid complexes for efficient in vivo delivery
|
US5965441A
(en)
*
|
1996-11-13 |
1999-10-12 |
The General Hospital Coporation |
HSV/AAV hybrid amplicon vectors
|
US7008776B1
(en)
|
1996-12-06 |
2006-03-07 |
Aventis Pharmaceuticals Inc. |
Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
|
BR9713847A
(pt)
|
1996-12-06 |
2000-02-29 |
Rhone Poulenc Rorer Pharma |
Polipeptìdeo isolado codificado por um gene semelhante a lipase, composição, composição farmacêutica, fragmento antigênico, ácido nucleico isolado, vetor, célula recombinante, anticorpo, célula de hibridoma, processos para preparar um polipeptìdeo, para triar agonistas ou antagonistas de atividade llg, para a hidrólise enzimática de um éster de fosfatidilcolina, e para melhorar o perfil de lipìdeo no soro de um humano ou outro animal tendo um perfil de lipìdeo indesejável, e, camundongo transgênico.
|
EP0958380A4
(en)
*
|
1996-12-06 |
2004-03-17 |
Univ California |
MACROMOLECUL LIPID COMPLEX AND METHOD FOR THE PRODUCTION AND USE THEREOF
|
US20020128240A1
(en)
*
|
1996-12-30 |
2002-09-12 |
Bone Care International, Inc. |
Treatment of hyperproliferative diseases using active vitamin D analogues
|
US6527716B1
(en)
|
1997-12-30 |
2003-03-04 |
Altea Technologies, Inc. |
Microporation of tissue for delivery of bioactive agents
|
US6929797B2
(en)
*
|
1997-02-13 |
2005-08-16 |
Bone Care International, Inc. |
Targeted therapeutic delivery of vitamin D compounds
|
US20030129194A1
(en)
*
|
1997-02-13 |
2003-07-10 |
Bone Care International, Inc. |
Targeted therapeutic delivery of vitamin D compounds
|
FR2760193B1
(fr)
*
|
1997-02-28 |
1999-05-28 |
Transgene Sa |
Lipides et complexes de lipides cationiques et de substances actives, notamment pour la transfection de cellules
|
US7112338B2
(en)
*
|
1997-03-12 |
2006-09-26 |
The Regents Of The University Of California |
Cationic liposome delivery of taxanes to angiogenic blood vessels
|
US5837283A
(en)
*
|
1997-03-12 |
1998-11-17 |
The Regents Of The University Of California |
Cationic lipid compositions targeting angiogenic endothelial cells
|
US5965542A
(en)
*
|
1997-03-18 |
1999-10-12 |
Inex Pharmaceuticals Corp. |
Use of temperature to control the size of cationic liposome/plasmid DNA complexes
|
US5948653A
(en)
*
|
1997-03-21 |
1999-09-07 |
Pati; Sushma |
Sequence alterations using homologous recombination
|
US5925628A
(en)
*
|
1997-03-31 |
1999-07-20 |
Genzyme Corporation |
Cationic amphiphiles for intracellular delivery of therapeutic molecules
|
US6235310B1
(en)
|
1997-04-04 |
2001-05-22 |
Valentis, Inc. |
Methods of delivery using cationic lipids and helper lipids
|
US5912239A
(en)
*
|
1997-04-04 |
1999-06-15 |
Genzyme Corporation |
Imidazole-containing cationic amphiphiles for intracellular delivery of therapeutic molecules
|
US5958894A
(en)
*
|
1997-04-04 |
1999-09-28 |
Megabios Corporation |
Amphiphilic biguanide derivatives
|
FR2761912B1
(fr)
*
|
1997-04-14 |
1999-07-02 |
Capsulis |
Procede destine a faire adherer un produit sur une surface
|
BR9808697A
(pt)
|
1997-04-28 |
2000-07-11 |
Rhone Poulenc Rorer Sa |
Processo para inibir o crescimento de um tumor, vetor de adenovìrus defeituoso, vetor de vìrus, uso do mesmo, e, composição farmacêutica
|
AU749410B2
(en)
*
|
1997-04-30 |
2002-06-27 |
Regents Of The University Of Minnesota |
In vivo use of recombinagenic oligonucleobases to correct genetic lesions in hepatocytes
|
US5948925A
(en)
*
|
1997-05-06 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphiles containing linkers derived from neutral or positively charged amino acids
|
US5952516A
(en)
*
|
1997-05-08 |
1999-09-14 |
Genzyme Corporation |
Cationic amphiphiles containing multiplesteroid lipophilic groups
|
US5942634A
(en)
*
|
1997-05-09 |
1999-08-24 |
Genzyme Corporation |
Cationic amphiphiles for cell transfections
|
WO1998051278A2
(en)
|
1997-05-14 |
1998-11-19 |
Inex Pharmaceuticals Corporation |
High efficiency encapsulation of charged therapeutic agents in lipid vesicles
|
US20030104044A1
(en)
*
|
1997-05-14 |
2003-06-05 |
Semple Sean C. |
Compositions for stimulating cytokine secretion and inducing an immune response
|
US6835395B1
(en)
|
1997-05-14 |
2004-12-28 |
The University Of British Columbia |
Composition containing small multilamellar oligodeoxynucleotide-containing lipid vesicles
|
AU8569698A
(en)
*
|
1997-07-11 |
1999-02-08 |
Brandeis University |
Method of inducing apoptosis by reducing the level of thiamin
|
US20090239940A1
(en)
*
|
1997-07-22 |
2009-09-24 |
Del Monte Federica |
Treating heart failure and ventricular arrhythmias
|
WO1999006563A1
(en)
|
1997-07-30 |
1999-02-11 |
Emory University |
Novel bone mineralization proteins, dna, vectors, expression systems
|
US7923250B2
(en)
|
1997-07-30 |
2011-04-12 |
Warsaw Orthopedic, Inc. |
Methods of expressing LIM mineralization protein in non-osseous cells
|
WO1999006576A1
(en)
|
1997-08-04 |
1999-02-11 |
Calydon, Inc. |
A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof
|
DE69840216D1
(de)
*
|
1997-08-08 |
2008-12-24 |
Celmed Oncology Usa Inc |
Verfahren und Zubereitungen um Resistenz gegen biologische oder chemische Therapien zu Überwinden
|
AU745958B2
(en)
*
|
1997-08-13 |
2002-04-11 |
Biontex Laboratories Gmbh |
Novel lipopolyamines, and the preparation and use thereof
|
US6818627B1
(en)
|
1997-08-14 |
2004-11-16 |
The Trustees Of The University Of Pennsylvania |
Functional fragments of HIV-1 Vpr protein and methods of using the same
|
US7704962B1
(en)
|
1997-10-03 |
2010-04-27 |
Board Of Regents, The University Of Texas System |
Small oligonucleotides with anti-tumor activity
|
US7285288B1
(en)
|
1997-10-03 |
2007-10-23 |
Board Of Regents, The University Of Texas System |
Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides
|
US6884842B2
(en)
|
1997-10-14 |
2005-04-26 |
Alnis Biosciences, Inc. |
Molecular compounds having complementary surfaces to targets
|
US6875606B1
(en)
|
1997-10-23 |
2005-04-05 |
The United States Of America As Represented By The Department Of Veterans Affairs |
Human α-7 nicotinic receptor promoter
|
US5998482A
(en)
*
|
1997-11-10 |
1999-12-07 |
David; Sunil A. |
Use of synthetic polycationic amphiphilic substances with fatty acid or hydrocarbon substituents as anti-sepsis agents
|
WO1999026663A2
(en)
*
|
1997-11-20 |
1999-06-03 |
Vical, Inc. |
Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor
|
ATE293994T1
(de)
*
|
1997-12-01 |
2005-05-15 |
Fang Fang |
Multivalente rekombinante antikörper zur behandlung von hrv infektionen
|
US7179892B2
(en)
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
US7964192B1
(en)
|
1997-12-02 |
2011-06-21 |
Janssen Alzheimer Immunotherapy |
Prevention and treatment of amyloidgenic disease
|
TWI239847B
(en)
|
1997-12-02 |
2005-09-21 |
Elan Pharm Inc |
N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease
|
FR2772047B1
(fr)
*
|
1997-12-05 |
2004-04-09 |
Ct Nat D Etudes Veterinaires E |
Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
|
US20010003580A1
(en)
|
1998-01-14 |
2001-06-14 |
Poh K. Hui |
Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
|
WO1999036514A1
(en)
*
|
1998-01-16 |
1999-07-22 |
California Pacific Medical Center Research Institute |
Methods and compositions for gene delivery
|
US7462605B2
(en)
*
|
1998-01-23 |
2008-12-09 |
Celmed Oncology (Usa), Inc. |
Phosphoramidate compounds and methods of use
|
PT1045897E
(pt)
|
1998-01-23 |
2002-07-31 |
Newbiotics Inc |
Agentes terapeuticos por catalise enzimatica
|
US6410328B1
(en)
*
|
1998-02-03 |
2002-06-25 |
Protiva Biotherapeutics Inc. |
Sensitizing cells to compounds using lipid-mediated gene and compound delivery
|
AU3072799A
(en)
|
1998-03-19 |
1999-10-11 |
Human Genome Sciences, Inc. |
Cytokine receptor common gamma chain like
|
US6271209B1
(en)
*
|
1998-04-03 |
2001-08-07 |
Valentis, Inc. |
Cationic lipid formulation delivering nucleic acid to peritoneal tumors
|
US6043390A
(en)
|
1998-04-03 |
2000-03-28 |
The Regents Of The University Of California |
Pentaerythritol lipid derivatives and nucleic-acid complexes
|
EP1075519B1
(en)
|
1998-05-06 |
2005-11-09 |
Vlaams Interuniversitair Instituut voor Biotechnologie vzw. |
Inhibitors of nf-kb activation
|
US6225456B1
(en)
|
1998-05-07 |
2001-05-01 |
University Technololy Corporation |
Ras suppressor SUR-5
|
US6506889B1
(en)
|
1998-05-19 |
2003-01-14 |
University Technology Corporation |
Ras suppressor SUR-8 and related compositions and methods
|
WO1999061590A1
(en)
*
|
1998-05-29 |
1999-12-02 |
The Scripps Research Institute |
Methods and compositions useful for modulation of angiogenesis using tyrosine kinase src
|
US6726925B1
(en)
|
1998-06-18 |
2004-04-27 |
Duke University |
Temperature-sensitive liposomal formulation
|
US6200598B1
(en)
*
|
1998-06-18 |
2001-03-13 |
Duke University |
Temperature-sensitive liposomal formulation
|
US20040077603A1
(en)
*
|
1998-08-28 |
2004-04-22 |
Wilhelm Stoffel |
Synthetic tear fluid
|
PT1832657E
(pt)
*
|
1998-09-09 |
2013-01-08 |
Genzyme Corp |
Metilação de vectores plasmídicos
|
US6135976A
(en)
|
1998-09-25 |
2000-10-24 |
Ekos Corporation |
Method, device and kit for performing gene therapy
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
WO2000027795A1
(en)
|
1998-11-12 |
2000-05-18 |
Invitrogen Corporation |
Transfection reagents
|
AU1828100A
(en)
|
1998-11-25 |
2000-06-13 |
Gene Therapy Systems, Inc. |
Amphiphilic polyamine compounds
|
WO2000030444A1
(en)
*
|
1998-11-25 |
2000-06-02 |
Vanderbilt University |
Cationic liposomes for gene transfer
|
US20030035798A1
(en)
*
|
2000-08-16 |
2003-02-20 |
Fang Fang |
Humanized antibodies
|
US7868162B2
(en)
|
1998-12-30 |
2011-01-11 |
Lakewood-Amedex, Inc. |
Antimicrobial and antiviral compounds and methods for their use
|
US20020032164A1
(en)
|
1998-12-30 |
2002-03-14 |
Dale Roderic M. K. |
Antimicrobial compounds and methods for their use
|
US6627215B1
(en)
|
1998-12-30 |
2003-09-30 |
Oligos Etc. Inc. |
Devices for improved wound management
|
US6441156B1
(en)
|
1998-12-30 |
2002-08-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Calcium channel compositions and methods of use thereof
|
US6570003B1
(en)
*
|
2001-01-09 |
2003-05-27 |
Lexion Genetics Incorporated |
Human 7TM proteins and polynucleotides encoding the same
|
EP1147204A1
(en)
*
|
1999-01-28 |
2001-10-24 |
Medical College Of Georgia Research Institute, Inc. |
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
|
DE50000562D1
(de)
|
1999-02-25 |
2002-10-31 |
Von Strandmann Elke Pogge |
Mittel zur behandlung von pigmentierungsstörungen
|
JP2002538090A
(ja)
|
1999-03-03 |
2002-11-12 |
ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア |
ワクチンおよび遺伝子治療組成物およびその作製および使用法
|
US7393548B2
(en)
*
|
1999-03-22 |
2008-07-01 |
J.P. M.E.D. Ltd. |
Nano oil in glycerin emulsion
|
EP1163359A4
(en)
|
1999-03-24 |
2005-01-26 |
Gene Therapy Systems Inc |
PROCESS FOR PRODUCING TRANSCRIPTIONALLY ACTIVE DNA FRAGMENTS
|
ES2308069T3
(es)
|
1999-03-26 |
2008-12-01 |
Vical Incorporated |
Composiciones adyuvantes para realzar inmunorespuestas a las vacunas polinucleotido-basadas.
|
US6379698B1
(en)
|
1999-04-06 |
2002-04-30 |
Isis Pharmaceuticals, Inc. |
Fusogenic lipids and vesicles
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
WO2000073263A1
(en)
*
|
1999-05-28 |
2000-12-07 |
Vical Incorporated |
Cytofectin dimers and methods of use thereof
|
US6696424B1
(en)
|
1999-05-28 |
2004-02-24 |
Vical Incorporated |
Cytofectin dimers and methods of use thereof
|
UA81216C2
(en)
|
1999-06-01 |
2007-12-25 |
|
Prevention and treatment of amyloid disease
|
US6943152B1
(en)
|
1999-06-10 |
2005-09-13 |
Merial |
DNA vaccine-PCV
|
US20010048940A1
(en)
*
|
1999-06-18 |
2001-12-06 |
Jennifer D. Tousignant |
Cationic amphiphile micellar complexes
|
FR2797402B1
(fr)
|
1999-07-15 |
2004-03-12 |
Biomerieux Stelhys |
Utilisation d'un polypeptide pour detecter, prevenir ou traiter un etat pathologique associe a une maladie degenerative, neurologique ou autoimmune
|
US6683061B1
(en)
|
1999-07-22 |
2004-01-27 |
Newbiotics, Inc. |
Enzyme catalyzed therapeutic activation
|
EP1200130A2
(en)
|
1999-07-22 |
2002-05-02 |
Newbiotics, Inc. |
Methods for treating therapy-resistant tumors
|
US20030078499A1
(en)
*
|
1999-08-12 |
2003-04-24 |
Eppstein Jonathan A. |
Microporation of tissue for delivery of bioactive agents
|
US20050249794A1
(en)
*
|
1999-08-27 |
2005-11-10 |
Semple Sean C |
Compositions for stimulating cytokine secretion and inducing an immune response
|
AUPQ259399A0
(en)
*
|
1999-09-01 |
1999-09-23 |
Lustre Investments Pte Ltd |
Therapeutic agents
|
US20050153323A1
(en)
*
|
2000-07-28 |
2005-07-14 |
Yi Hu |
Novel human proteases and polynucleotides encoding the same
|
US20020165376A1
(en)
*
|
1999-12-22 |
2002-11-07 |
Walke D. Wade |
Novel human proteases and polynucleotides encoding the same
|
US20030050464A1
(en)
*
|
2000-07-28 |
2003-03-13 |
Yi Hu |
Novel human proteases and polynucleotides encoding the same
|
US6448388B1
(en)
|
2000-08-16 |
2002-09-10 |
Lexicon Genetics Incorporated |
Human proteases and polynucleotides encoding the same
|
US20080003673A1
(en)
*
|
1999-09-02 |
2008-01-03 |
Alejandro Abuin |
Novel human proteases and polynucleotides encoding the same
|
US6716614B1
(en)
|
1999-09-02 |
2004-04-06 |
Lexicon Genetics Incorporated |
Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
|
ES2258471T3
(es)
*
|
1999-09-09 |
2006-09-01 |
The Regents Of The University Of California |
Suministro de liposomas cationicos de taxanos a vasos sanguineos angiogenicos.
|
US20020107382A1
(en)
*
|
2000-09-27 |
2002-08-08 |
Friddle Carl Johan |
Novel human protease inhibitor proteins and polynucleotides encoding the same
|
US6867291B1
(en)
*
|
2000-09-15 |
2005-03-15 |
Lexicon Genetics Incorporated |
Human hemicentin proteins and polynucleotides encoding the same
|
US6790660B1
(en)
*
|
2001-09-18 |
2004-09-14 |
Lexicon Genetics Incorporated |
Human kielin-like proteins and polynucleotides encoding the same
|
US6797510B1
(en)
*
|
2001-05-24 |
2004-09-28 |
Lexicon Genetics Incorporated |
Human kinases and polynucleotides encoding the same
|
US6864079B2
(en)
|
2001-04-06 |
2005-03-08 |
Lexicon Genetics Incorporated |
Human kinase and polynucleotides encoding the same
|
US6720173B1
(en)
|
1999-11-08 |
2004-04-13 |
Lexicon Genetics Incorporated |
Human kinase protein and polynucleotides encoding the same
|
US6586230B1
(en)
*
|
2000-10-27 |
2003-07-01 |
Lexicon Genetics Incorporated |
Human kinase and polynucleotides encoding the same
|
US6841377B1
(en)
*
|
2001-06-13 |
2005-01-11 |
Lexicon Genetics Incorporated |
Human kinase and polynucleotides encoding the same
|
US20080050809A1
(en)
*
|
1999-09-28 |
2008-02-28 |
Alejandro Abuin |
Novel human kinases and polynucleotides encoding the same
|
US6541252B1
(en)
|
2000-05-19 |
2003-04-01 |
Lexicon Genetics Incorporated |
Human kinases and polynucleotides encoding the same
|
US6511840B1
(en)
|
2000-06-15 |
2003-01-28 |
Lexicon Genetics Incorporated |
Human kinase proteins and polynucleotides encoding the same
|
US7892541B1
(en)
|
1999-09-30 |
2011-02-22 |
Tumor Biology Investment Group, Inc. |
Soluble epidermal growth factor receptor isoforms
|
US20030013865A1
(en)
*
|
2001-03-12 |
2003-01-16 |
Yu Xuanchuan (Sean) |
Novel human EGF-family proteins and polynucleotides encoding the same
|
US20080213878A1
(en)
*
|
1999-10-19 |
2008-09-04 |
Gregory Donoho |
Novel human membrane proteins and polynucleotides encoding the same
|
CA2390650A1
(en)
|
1999-11-12 |
2001-05-17 |
Lexicon Genetics Incorporated |
Novel human proteases and polynucleotides encoding the same
|
WO2001036469A2
(en)
*
|
1999-11-19 |
2001-05-25 |
Lexicon Genetics Incorporated |
Human ceruloplasmin
|
ES2170622B1
(es)
*
|
1999-12-03 |
2004-05-16 |
Consejo Superior De Investigaciones Cientificas |
Clones y vectores infectivos derivados de coronavirus y sus aplicaciones.
|
CA2393332A1
(en)
|
1999-12-07 |
2001-06-14 |
Lexicon Genetics Incorporated |
Novel human kinase proteins and polynucleotides encoding the same
|
JP2003527838A
(ja)
*
|
1999-12-07 |
2003-09-24 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒト膜タンパクおよびそれをコードするポリヌクレオチド
|
AU784376B2
(en)
*
|
1999-12-13 |
2006-03-23 |
Lexicon Pharmaceuticals, Inc. |
Novel human transferase proteins and polynucleotides encoding the same
|
US20030008813A1
(en)
*
|
1999-12-17 |
2003-01-09 |
Felgner Philip L. |
Intracellular protein delivery compositions and methods of use
|
CA2395247A1
(en)
*
|
1999-12-22 |
2001-06-28 |
Lexicon Genetics Incorporated |
Novel human membrane proteins and polynucleotides encoding the same
|
FR2802925B1
(fr)
*
|
1999-12-23 |
2002-03-22 |
Commissariat Energie Atomique |
Amphiphiles cationiques, leurs applications et leur procede de synthese
|
WO2001048164A2
(en)
*
|
1999-12-27 |
2001-07-05 |
The Regents Of The University Of California |
Modified adenylylcyclase type vi useful in gene therapy for congestive heart failure
|
AU3366901A
(en)
*
|
1999-12-30 |
2001-07-16 |
Novartis Ag |
Novel colloid synthetic vectors for gene therapy
|
CA2402360A1
(en)
*
|
2000-01-06 |
2001-07-12 |
Lexicon Genetics Incorporated |
Novel human proteases and polynucleotides encoding the same
|
JP2004504804A
(ja)
*
|
2000-01-18 |
2004-02-19 |
レキシコン・ジェネティクス・インコーポレーテッド |
ヒト新規キナーゼタンパクおよびそれをコードするポリヌクレオチド
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
US6852705B2
(en)
|
2000-01-21 |
2005-02-08 |
Merial |
DNA vaccines for farm animals, in particular bovines and porcines
|
US20040002472A1
(en)
*
|
2000-01-21 |
2004-01-01 |
Audonnet Jean-Christophe Francis |
Vaccination or immunization using a prime-boost regimen
|
US7078388B2
(en)
*
|
2000-01-21 |
2006-07-18 |
Merial |
DNA vaccines for farm animals, in particular bovines and porcines
|
AU2001253117B8
(en)
*
|
2000-01-26 |
2006-08-03 |
Lexicon Pharmaceuticals, Inc. |
Human neurexin-like proteins and polynucleotides encoding the same
|
WO2001055394A1
(en)
*
|
2000-01-28 |
2001-08-02 |
Lexicon Genetics Incorporated |
Human membrane proteins and polynucleotides encoding the same
|
WO2001094566A2
(en)
*
|
2000-01-28 |
2001-12-13 |
Lexicon Genetics Incorporated |
Human enzymes and polynucleotides encoding the same
|
WO2001057220A2
(en)
*
|
2000-02-04 |
2001-08-09 |
Lexicon Genetics Incorporated |
Human enzymes and polynucleotides encoding the same
|
WO2001057086A2
(en)
*
|
2000-02-04 |
2001-08-09 |
Lexicon Genetics Incorporated |
Novel human g protein coupled receptor proteins and polynucleotides encoding the same
|
ATE483970T1
(de)
|
2000-02-08 |
2010-10-15 |
Sangamo Biosciences Inc |
Zellen zur entdeckung von medikamenten
|
CA2399876A1
(en)
|
2000-02-11 |
2001-08-16 |
Lexicon Genetics Incorporated |
Human proteases and polynucleotides encoding the same
|
CN1280103C
(zh)
|
2000-02-16 |
2006-10-18 |
精工爱普生株式会社 |
喷墨打印机用连接组件及喷墨打印机
|
AU2001238503A1
(en)
|
2000-02-17 |
2001-08-27 |
Lexicon Genetics Incorporated |
Novel human thrombospondin repeat proteins and polynucleotides encoding the same
|
WO2001064903A2
(en)
*
|
2000-02-29 |
2001-09-07 |
Lexicon Genetics Incorporated |
Novel human transferase proteins and polynucleotides encoding the same
|
CA2401645A1
(en)
*
|
2000-02-29 |
2001-09-07 |
Lexicon Genetics Incorporated |
Novel human transporter proteins and polynucleotides encoding the same
|
US20020082405A1
(en)
*
|
2000-03-06 |
2002-06-27 |
Gregory Donoho |
Novel human transporter proteins and polynucleotides encoding the same
|
AU4352101A
(en)
|
2000-03-10 |
2001-09-24 |
Lexicon Genetics Inc |
Novel human g-coupled protein receptor kinases and polynucleotides encoding the same
|
AU4739501A
(en)
*
|
2000-03-13 |
2001-09-24 |
Lexicon Genetics Inc |
Novel human phospholipases and polynucleotides encoding the same
|
DK1274464T3
(da)
|
2000-03-13 |
2012-01-23 |
Engene Inc |
Sammensætninger og fremgangsmåder til regulering af proteinekspression i tarm
|
ES2368419T3
(es)
|
2000-03-13 |
2011-11-17 |
Cornell Research Foundation, Inc. |
Bloqueo de la migración de leucocitos y de la inflamación por interferencia con cd99/hec2.
|
EP1268538A2
(en)
*
|
2000-03-20 |
2003-01-02 |
Lexicon Genetics Incorporated |
Human secreted proteins and polynucleotides encoding the same
|
AU2001249389A1
(en)
*
|
2000-03-22 |
2001-10-03 |
The Children's Hospital Of Philadelphia |
Modified blood clotting factors and methods of use
|
US20040033600A1
(en)
*
|
2001-03-21 |
2004-02-19 |
Palli Subba Reddy |
Ecdysone receptor-based inducible gene expression system
|
GB0018307D0
(en)
|
2000-07-26 |
2000-09-13 |
Aventis Pharm Prod Inc |
Polypeptides
|
CA2404896A1
(en)
|
2000-04-03 |
2001-10-11 |
Lexicon Genetics Incorporated |
Human ion channel protein and polynucleotides encoding the same
|
EP1278544A4
(en)
|
2000-04-12 |
2004-08-18 |
Human Genome Sciences Inc |
ALBUMIN FUSION PROTEINS
|
EP1272644A1
(en)
*
|
2000-04-12 |
2003-01-08 |
Lexicon Genetics Incorporated |
Human metalloprotease and polynucleotides encoding the same
|
WO2001079299A1
(en)
|
2000-04-13 |
2001-10-25 |
The Rockefeller University |
Enhancement of antibody-mediated immune responses
|
US7189705B2
(en)
|
2000-04-20 |
2007-03-13 |
The University Of British Columbia |
Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
|
WO2001080897A2
(en)
*
|
2000-04-21 |
2001-11-01 |
Vical Incorporated |
Compositions and methods for in vivo delivery of polynucleotide-based therapeutics
|
AU2001257195B2
(en)
|
2000-04-25 |
2006-10-05 |
Lexicon Pharmaceuticals, Inc. |
Novel human kinase proteins and polynucleotides encoding the same
|
WO2001088134A2
(en)
*
|
2000-05-12 |
2001-11-22 |
Lexicon Genetics Incorporated |
Novel human lipocalin homologs and polynucleotides encoding the same
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
WO2001088133A2
(en)
*
|
2000-05-18 |
2001-11-22 |
Lexicon Genetics Incorporated |
Human semaphorin homologs and polynucleotides encoding the same
|
AU2001274923A1
(en)
*
|
2000-05-23 |
2001-12-03 |
Lexicon Genetics Incorporated |
Novel human thrombospondin-like proteins and polynucleotides encoding the same
|
US6790667B1
(en)
*
|
2000-05-30 |
2004-09-14 |
Lexicon Genetics Incorporated |
Human mitochondrial proteins and polynucleotides encoding the same
|
EP2298799B1
(en)
|
2000-06-05 |
2017-11-15 |
The Brigham and Women's Hospital, Inc. |
A gene encoding a multidrug resistance human p-glycoprotein homologue on chromosome 7p15-21 and uses thereof
|
US6703495B2
(en)
*
|
2000-06-07 |
2004-03-09 |
Lexicon Genetics Incorporated |
Polynucleotides encoding human transporter protein
|
US20040204379A1
(en)
*
|
2000-06-19 |
2004-10-14 |
Cheng Seng H. |
Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases
|
DK1295611T3
(da)
*
|
2000-06-20 |
2010-10-04 |
Dainippon Sumitomo Pharma Co |
Oligonukleotid-transformerende forbindelser
|
AU7151601A
(en)
*
|
2000-06-27 |
2002-01-08 |
Lexicon Genetics Inc |
Novel human gaba receptors and polynucleotides encoding the same
|
EP1301479A2
(en)
*
|
2000-07-18 |
2003-04-16 |
Bone Care International, Inc. |
STABILIZED 1$g(a)-HYDROXY VITAMIN D
|
AU2002224553A1
(en)
*
|
2000-07-21 |
2002-02-05 |
Incyte Genomics, Inc. |
Human proteases
|
US6887685B1
(en)
*
|
2000-07-25 |
2005-05-03 |
Lexicon Genetics Incorporated |
Human thymosin protein and polynucleotides encoding the same
|
AU8467201A
(en)
*
|
2000-07-27 |
2002-02-13 |
Univ Pennsylvania |
Compositions for and methods of using herpes simplex virus glycoprotein d to suppress immune responses
|
US20020076780A1
(en)
*
|
2000-08-16 |
2002-06-20 |
Turner C. Alexander |
Novel human ion channel proteins and polynucleotides encoding the same
|
EP1311690B1
(en)
*
|
2000-08-22 |
2006-07-26 |
Lexicon Genetics Incorporated |
Human proteases and polynucleotides encoding the same
|
AU2001286792A1
(en)
*
|
2000-08-22 |
2002-03-04 |
Lexicon Genetics Incorporated |
Novel human 7TM proteins and polynucleotides encoding the same
|
BR0113512A
(pt)
|
2000-08-25 |
2005-05-10 |
Basf Plant Science Gmbh |
Polinucleotìdeos de planta que codificam novas prenil proteases
|
AU2001285326A1
(en)
*
|
2000-08-31 |
2002-03-13 |
Lexicon Genetics Incorporated |
Human kinase proteins and polynucleotides encoding the same
|
WO2002020753A2
(en)
*
|
2000-09-01 |
2002-03-14 |
Lexicon Genetics Incorporated |
Human gaba transporter protein and polynucleotides encoding the same
|
ATE326533T1
(de)
*
|
2000-09-27 |
2006-06-15 |
Lexicon Genetics Inc |
Menschliche ionenaustauschproteine und dafür kodierende polynukleotiden
|
US6777232B1
(en)
*
|
2000-10-02 |
2004-08-17 |
Lexicon Genetics Incorporated |
Human membrane proteins and polynucleotides encoding the same
|
US8105825B2
(en)
*
|
2000-10-03 |
2012-01-31 |
Intrexon Corporation |
Multiple inducible gene regulation system
|
US20050059031A1
(en)
|
2000-10-06 |
2005-03-17 |
Quantum Dot Corporation |
Method for enhancing transport of semiconductor nanocrystals across biological membranes
|
AU2002213183A1
(en)
|
2000-10-12 |
2002-04-22 |
Lexicon Genetics Incorporated |
Human kinases and polynucleotides encoding the same
|
US7001763B1
(en)
|
2000-10-17 |
2006-02-21 |
Lexicon Genetics Incorporated |
Human semaphorin proteins and polynucleotides encoding the same
|
US6831059B2
(en)
|
2000-10-20 |
2004-12-14 |
Allergan, Inc. |
Compositions and methods for treating gonadotrophin related illnesses
|
WO2002034879A2
(en)
*
|
2000-10-27 |
2002-05-02 |
Invitrogen Corporation |
Method for introducing antisense oligonucleotides into eucaryotic cells
|
WO2002070705A2
(en)
*
|
2000-10-27 |
2002-09-12 |
Lexicon Genetics Incorporated |
Human 7tm proteins and polynucleotides encoding them
|
JP2004531209A
(ja)
*
|
2000-10-30 |
2004-10-14 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒト7tmタンパクおよびそれをコードするポリヌクレオチド
|
US7060442B2
(en)
*
|
2000-10-30 |
2006-06-13 |
Regents Of The University Of Michigan |
Modulators on Nod2 signaling
|
DE60122389T2
(de)
*
|
2000-11-01 |
2007-08-02 |
Lexicon Genetics Inc., The Woodlands |
Polynukleotide die für humane meltrin beta (adam19) metalloendopeptidasen kodieren
|
JP2004535154A
(ja)
*
|
2000-11-15 |
2004-11-25 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒト分泌タンパク質およびそれをコードするポリヌクレオチド
|
WO2002042438A2
(en)
*
|
2000-11-20 |
2002-05-30 |
Lexicon Genetics Incorporated |
Human kinases and polynucleotides encoding the same
|
BR0115795A
(pt)
*
|
2000-11-29 |
2003-08-12 |
Pci Biotech As |
Métodos para introduzir uma molécula no citosol de uma célula, para o tratamento ou prevenção de uma doença, distúrbio ou infecção em um paciente, para estimular uma resposta imune, célula, e, uso de uma molécula de transferência e/ou um agente fotossensibilizante
|
TWI255272B
(en)
|
2000-12-06 |
2006-05-21 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
JP2004517622A
(ja)
|
2000-12-11 |
2004-06-17 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒトキナーゼ及び該キナーゼをコードするポリヌクレオチド
|
WO2002048333A2
(en)
*
|
2000-12-12 |
2002-06-20 |
Lexicon Genetics Incorporated |
Novel human kinases and uses thereof
|
US6583269B1
(en)
*
|
2000-12-18 |
2003-06-24 |
Lexicon Genetics Incorporated |
Human protease inhibitor and polynucleotides encoding the same
|
US6852844B1
(en)
*
|
2000-12-20 |
2005-02-08 |
Lexicon Genetics Incorporated |
Human protocadherin proteins and polynucleotides encoding the same
|
CA2432737A1
(en)
*
|
2000-12-20 |
2002-06-27 |
Lexicon Genetics Incorporated |
Human ion channel protein and polynucleotides encoding the same
|
DE10064870B4
(de)
*
|
2000-12-27 |
2004-10-07 |
G.O.T. Gesellschaft Zur Therapieoptimierung Und Targeting Entwicklungs Mbh |
Schwefelhaltige Amphiphile für den Transfer von biologisch aktiven Molekülen in Zellen
|
AU2002246858A1
(en)
*
|
2000-12-27 |
2002-08-06 |
Lexicon Genetics Incorporated |
Human kinases and polynucleotides encoding the same
|
EP1355918B9
(en)
|
2000-12-28 |
2012-01-25 |
Wyeth LLC |
Recombinant protective protein from $i(streptococcus pneumoniae)
|
US20020115844A1
(en)
*
|
2001-01-05 |
2002-08-22 |
Yu Xuanchuan Sean |
Novel human lipase and polynucleotides encoding the same
|
WO2002053754A2
(en)
*
|
2001-01-08 |
2002-07-11 |
Lexicon Genetics Incorporated |
Human protease and polynucleotides encoding the same
|
CA2441350A1
(en)
*
|
2001-01-19 |
2002-07-25 |
Newbiotics, Inc. |
Methods to treat autoimmune and inflammatory conditions
|
JP2004524835A
(ja)
*
|
2001-01-23 |
2004-08-19 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒトキナーゼおよびそれをコードするポリヌクレオチド
|
JP2005502311A
(ja)
*
|
2001-01-24 |
2005-01-27 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒトリパーゼ及び該リパーゼをコードするポリヌクレオチド
|
EP1229134A3
(en)
*
|
2001-01-31 |
2004-01-28 |
Nucleonics, Inc |
Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
|
WO2002063002A2
(en)
*
|
2001-02-02 |
2002-08-15 |
Lexicon Genetics Incorporated |
Novel human transporter protein and polynucleotides encoding the same
|
EP1373470B1
(en)
|
2001-02-20 |
2013-04-24 |
Intrexon Corporation |
Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
JP4955904B2
(ja)
|
2001-02-20 |
2012-06-20 |
イントレキソン コーポレーション |
新規エクジソン受容体/無脊椎動物レチノイドx受容体−ベースの誘導性遺伝子発現システム
|
JP2004529623A
(ja)
*
|
2001-02-20 |
2004-09-30 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規プロテアーゼおよびそれをコードするポリヌクレオチド
|
CA2438119C
(en)
|
2001-02-20 |
2014-12-16 |
Rheogene Holdings, Inc. |
Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
|
ES2390070T3
(es)
|
2001-02-20 |
2012-11-06 |
Intrexon Corporation |
Nuevos receptores mutantes de sustitución y su uso en un sistema de expresión génica inducible basado en receptores nucleares
|
JP2005508134A
(ja)
|
2001-03-02 |
2005-03-31 |
ザ ロックフェラー ユニヴァーシティ |
天然アレルゲンの免疫原性を保持する、アレルゲン性が低下した組み換えハイブリッドアレルゲン構築体
|
JP3929250B2
(ja)
*
|
2001-03-08 |
2007-06-13 |
株式会社ルネサステクノロジ |
半導体装置
|
US20020164627A1
(en)
*
|
2001-03-12 |
2002-11-07 |
Wilganowski Nathaniel L. |
Novel human transporter proteins and polynucleotides encoding the same
|
AU2002245593A1
(en)
*
|
2001-03-12 |
2002-09-24 |
Lexicon Genetics Incorporated |
Novel human dectin proteins and polynucleotides encoding the same
|
US20030091544A1
(en)
*
|
2001-03-13 |
2003-05-15 |
Vical Incorporated |
Interferon-Beta polynucleotide therapy for autoimmune and inflammatory diseases
|
US6994995B1
(en)
|
2001-03-16 |
2006-02-07 |
Lexicon Genetics Incorporated |
Human synaptotagmin and polynucleotides encoding the same
|
WO2002074932A2
(en)
|
2001-03-20 |
2002-09-26 |
Lexicon Genetics Incorporated |
Novel human kinase and polynucleotides encoding the same
|
US6613534B2
(en)
|
2001-03-20 |
2003-09-02 |
Wake Forest University Health Sciences |
MAP-2 as a determinant of metastatic potential
|
US7294511B2
(en)
|
2001-03-22 |
2007-11-13 |
Chromos Molecular Systems, Inc. |
Methods for delivering nucleic acid molecules into cells and assessment thereof
|
US20030186390A1
(en)
*
|
2001-03-22 |
2003-10-02 |
De Jong Gary |
Methods for delivering nucleic acid molecules into cells and assessment thereof
|
US6936469B2
(en)
*
|
2001-03-22 |
2005-08-30 |
Chromos Molecular Systems Inc. |
Methods for delivering nucleic acid molecules into cells and assessment thereof
|
US20030096414A1
(en)
|
2001-03-27 |
2003-05-22 |
Invitrogen Corporation |
Culture medium for cell growth and transfection
|
US20040028651A1
(en)
*
|
2001-03-29 |
2004-02-12 |
Karrupiah Muthumani |
Composition and methods of using hiv vpr
|
WO2002080849A2
(en)
*
|
2001-04-06 |
2002-10-17 |
University Of Chicago |
Chemotherapeutic induction of egr-1 promoter activity
|
US20040242523A1
(en)
*
|
2003-03-06 |
2004-12-02 |
Ana-Farber Cancer Institue And The Univiersity Of Chicago |
Chemo-inducible cancer gene therapy
|
US8034791B2
(en)
|
2001-04-06 |
2011-10-11 |
The University Of Chicago |
Activation of Egr-1 promoter by DNA damaging chemotherapeutics
|
EP1383879A4
(en)
*
|
2001-04-06 |
2005-05-11 |
Lexicon Genetics Inc |
HUMAN KINASES AND POLYNUCLEOTIDES ENCODING SAME
|
US6644173B2
(en)
*
|
2001-04-11 |
2003-11-11 |
Keuring, Incorporated |
Beverage filter cartridge holder
|
JP2004536579A
(ja)
|
2001-04-13 |
2004-12-09 |
ヒューマン ジノーム サイエンシーズ, インコーポレイテッド |
血管内皮増殖因子2
|
US20070128229A1
(en)
*
|
2002-04-12 |
2007-06-07 |
Wyeth |
Surface proteins of Streptococcus pyogenes
|
IL158328A0
(en)
*
|
2001-04-13 |
2004-05-12 |
Wyeth Corp |
Surface proteins of streptococcus pyogenes
|
US6607895B2
(en)
|
2001-04-16 |
2003-08-19 |
Lexicon Genetics Incorporated |
Human adenylsuccinate synthetase and polynucleotides encoding the same
|
US20020165175A1
(en)
*
|
2001-04-17 |
2002-11-07 |
Xiaowu Liang |
Fast and enzymeless cloning of nucleic acid fragments
|
CA2445947A1
(en)
*
|
2001-04-30 |
2002-11-07 |
Targeted Genetics Corporation |
Lipid-comprising drug delivery complexes and methods for their production
|
WO2002088313A2
(en)
*
|
2001-04-30 |
2002-11-07 |
Lexicon Genetics Incorporated |
Novel human nuclear transporters and polynucleotides encoding the same
|
WO2002087541A1
(en)
*
|
2001-04-30 |
2002-11-07 |
Protiva Biotherapeutics Inc. |
Lipid-based formulations for gene transfer
|
CA2446967A1
(en)
*
|
2001-05-09 |
2002-11-14 |
Lexicon Genetics Incorporated |
Novel human kinases and polynucleotides encoding the same
|
US20020193585A1
(en)
*
|
2001-05-25 |
2002-12-19 |
Walke D. Wade |
Novel human transporter proteins and polynucleotides encoding the same
|
JP2005500829A
(ja)
|
2001-05-29 |
2005-01-13 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒト水酸化酵素及び該酵素をコードするポリヌクレオチド
|
US7744882B2
(en)
|
2001-05-31 |
2010-06-29 |
Tumor Biology Investment Group, Inc. |
Soluble ErbB3 methods of detection and antibodies
|
US7745398B2
(en)
*
|
2001-05-31 |
2010-06-29 |
Tumor Biology Investment Group, Inc. |
Soluble ErbB3 and treatment of cancer
|
EP1406645A4
(en)
*
|
2001-06-14 |
2005-02-16 |
Lexicon Genetics Inc |
NOVEL HUMAN TRANSPORTER PROTEINS AND POLYNUCLEOTIDES ENCODING THESE PROTEINS
|
ES2324525T3
(es)
*
|
2001-06-20 |
2009-08-10 |
Dainippon Sumitomo Pharma Co., Ltd. |
Metodo para promover transferencia de acidos nucleicos.
|
CA2633413C
(en)
|
2001-06-20 |
2012-08-21 |
Genentech, Inc. |
Antibodies against tumor-associated antigenic target (tat) polypeptides
|
US7803915B2
(en)
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
CA2790034A1
(en)
|
2001-06-21 |
2003-01-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
WO2003000280A2
(en)
|
2001-06-22 |
2003-01-03 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
Abin-mediated hepatitis protection
|
WO2003000174A2
(en)
*
|
2001-06-26 |
2003-01-03 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Compositions and methods for intracellular delivery
|
WO2003004609A2
(en)
*
|
2001-07-03 |
2003-01-16 |
Lexicon Genetics Incorporated |
Novel human kielin-like proteins and polynucleotides encoding the same
|
IL159722A0
(en)
|
2001-07-10 |
2004-06-20 |
Oligos Etc Inc |
Pharmaceutical compositions containing oligonucleotides
|
JP2005522192A
(ja)
|
2001-07-19 |
2005-07-28 |
パーラン セラピューティクス, インコーポレイテッド |
マルチマータンパク質およびマルチマータンパク質を作製および使用する方法
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
EP1572885A2
(en)
*
|
2001-08-08 |
2005-09-14 |
Genzyme Corporation |
Methods for treating diabetes and other blood sugar disorders
|
US20040143104A1
(en)
*
|
2001-08-08 |
2004-07-22 |
Wadsworth Samuel C. |
Methods of treating diabetes and other blood sugar disorders
|
JP2005500060A
(ja)
*
|
2001-08-14 |
2005-01-06 |
レキシコン・ジェネティクス・インコーポレーテッド |
新規ヒトコラーゲンタンパクおよびそれをコードするポリヌクレオチド
|
ATE516042T1
(de)
|
2001-09-18 |
2011-07-15 |
Genentech Inc |
Zusammensetzungen und verfahren zur behandlung und diagnose von tumoren
|
CA2461290C
(en)
|
2001-09-24 |
2014-11-25 |
Sangamo Biosciences, Inc. |
Modulation of stem cells using zinc finger proteins
|
US7177763B2
(en)
*
|
2001-09-25 |
2007-02-13 |
Werner Keber |
Method and device for preventing unpermitted approach of airplanes to objects on the ground which are to be protected
|
US7563879B2
(en)
*
|
2001-09-26 |
2009-07-21 |
Intrexon Corporation |
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
|
MXPA04002808A
(es)
*
|
2001-09-26 |
2005-06-06 |
Rheogene Holdings Inc |
Acidos nucleicos receptores de ecdisona de mosca blanca, polipeptidos, y sus usos.
|
US20040023910A1
(en)
*
|
2001-09-28 |
2004-02-05 |
Zhiming Zhang |
Use of cyr61 in the treatment and diagnosis of human uterine leiomyomas
|
US7906102B2
(en)
|
2001-10-03 |
2011-03-15 |
Vanderbilt University |
Ligands to radiation-induced molecules
|
EP1453548A4
(en)
*
|
2001-10-05 |
2005-10-26 |
Univ Pennsylvania |
COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF SIRS (SUPPRESSOR OF IMMUNE RESPONSES FACTOR) / SEPSIS
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
AU2002334895B2
(en)
|
2001-10-09 |
2006-10-19 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
MX339524B
(es)
|
2001-10-11 |
2016-05-30 |
Wyeth Corp |
Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
|
AU2002348163A1
(en)
*
|
2001-11-02 |
2003-05-19 |
Intradigm Corporation |
Therapeutic methods for nucleic acid delivery vehicles
|
IL161733A0
(en)
|
2001-11-02 |
2005-11-20 |
Insert Therapeutics Inc |
Methods and compositions for therapeutic use of rna interference
|
US7488313B2
(en)
*
|
2001-11-29 |
2009-02-10 |
Boston Scientific Scimed, Inc. |
Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
CA2469799A1
(en)
*
|
2001-12-14 |
2003-06-26 |
Transgene S.A. |
Use of a lysolipid for the preparation of a composition for transfection of a polynucleotide into a cell
|
MXPA04005942A
(es)
*
|
2001-12-20 |
2005-05-16 |
Schering Corp |
Composiciones y metodos de sintaxina 3.
|
US7255874B1
(en)
|
2001-12-21 |
2007-08-14 |
Closure Medical Corporation |
Biocompatible polymers and adhesives: compositions, methods of making and uses related thereto
|
EP2277910A1
(en)
|
2001-12-21 |
2011-01-26 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
EP2067472A1
(en)
|
2002-01-02 |
2009-06-10 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
WO2003057728A1
(en)
|
2002-01-10 |
2003-07-17 |
Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw |
A novel splice variant of myd88 and uses thereof
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
US20040014956A1
(en)
|
2002-02-01 |
2004-01-22 |
Sequitur, Inc. |
Double-stranded oligonucleotides
|
CA2476452A1
(en)
*
|
2002-02-15 |
2003-08-28 |
Zycos Inc. |
Electroporation methods for introducing bioactive agents into cells
|
DE10207177A1
(de)
*
|
2002-02-19 |
2003-09-04 |
Novosom Ag |
Fakultativ kationische Lipide
|
JP2005530704A
(ja)
*
|
2002-03-05 |
2005-10-13 |
トランセイブ, インク. |
細胞内感染を予防及び治療するための吸入システム
|
ES2612779T3
(es)
|
2002-03-11 |
2017-05-18 |
Nitto Denko Corporation |
Sistema de parches transdérmicos de administración de fármacos, método de fabricación del mismo y método de uso del mismo
|
US9918665B2
(en)
|
2002-03-11 |
2018-03-20 |
Nitto Denko Corporation |
Transdermal porator and patch system and method for using same
|
US8116860B2
(en)
|
2002-03-11 |
2012-02-14 |
Altea Therapeutics Corporation |
Transdermal porator and patch system and method for using same
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
AU2003230874A1
(en)
|
2002-04-16 |
2003-11-03 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
US20040180438A1
(en)
*
|
2002-04-26 |
2004-09-16 |
Pachuk Catherine J. |
Methods and compositions for silencing genes without inducing toxicity
|
US20040267355A1
(en)
*
|
2002-04-30 |
2004-12-30 |
Neal Scott |
Mechanical apparatus and method for dilating and delivering a therapeutic agent to a site of treatment
|
CA2495787A1
(en)
*
|
2002-05-01 |
2003-11-13 |
Chromos Molecular Systems, Inc. |
Methods for delivering nucleic acid molecules into cells and assessment thereof
|
EP2298358A1
(en)
*
|
2002-05-06 |
2011-03-23 |
Alnylam Pharmaceuticals Inc. |
Methods for delivery of nucleic acids
|
US7598421B2
(en)
*
|
2002-05-08 |
2009-10-06 |
Ucl Biomedica Plc |
Materials for the delivery of biologically-active material to cells
|
US20040013649A1
(en)
*
|
2002-05-10 |
2004-01-22 |
Inex Pharmaceuticals Corporation |
Cancer vaccines and methods of using the same
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
CA2486967A1
(en)
*
|
2002-05-24 |
2003-12-04 |
Neopharm, Inc. |
Cardiolipin compositions their methods of preparation and use
|
EA200401565A1
(ru)
*
|
2002-05-24 |
2005-04-28 |
Неофарм, Инк. |
Способ получения кардиолипина или аналога кардиолипина (варианты), способ получения липосомы и композиция кардиолипина для лечения заболеваний (варианты)
|
JP4563171B2
(ja)
|
2002-05-24 |
2010-10-13 |
シェーリング コーポレイション |
中和ヒト抗igfr抗体
|
CA2491164C
(en)
|
2002-06-28 |
2012-05-08 |
Cory Giesbrecht |
Method and apparatus for producing liposomes
|
US7473527B2
(en)
*
|
2002-07-02 |
2009-01-06 |
The Uab Research Foundation |
Compounds promoting delivery of genes
|
CN100340289C
(zh)
|
2002-07-05 |
2007-10-03 |
利普生技术有限公司 |
增强核酸接种免疫应答的方法
|
US7375093B2
(en)
|
2002-07-05 |
2008-05-20 |
Intrexon Corporation |
Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
EP1540004A4
(en)
*
|
2002-07-31 |
2007-10-03 |
Nucleonics Inc |
DOUBLE-STRING RNA STRUCTURES AND CONSTRUCTS AND METHOD FOR THE PRODUCTION AND USE THEREOF
|
US20040034336A1
(en)
*
|
2002-08-08 |
2004-02-19 |
Neal Scott |
Charged liposomes/micelles with encapsulted medical compounds
|
US7785608B2
(en)
*
|
2002-08-30 |
2010-08-31 |
Wyeth Holdings Corporation |
Immunogenic compositions for the prevention and treatment of meningococcal disease
|
US7135324B2
(en)
|
2002-09-04 |
2006-11-14 |
The University Of Connecticut |
Viral recombinases, related articles, and methods of use thereof
|
AU2003273271A1
(en)
*
|
2002-09-09 |
2004-03-29 |
The Brigham And Women's Hospital, Inc. |
Genes and proteins altering tau-related neurodegeneration
|
EP1575505A4
(en)
*
|
2002-09-10 |
2007-01-24 |
Vical Inc |
CODON OPTIMIZATION-BASED POLYNUCLEOTIDE VACCINES AGAINST BACILLUS ANTHRACIS INFECTION
|
AU2003267785C1
(en)
|
2002-09-13 |
2009-12-24 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
US20040053895A1
(en)
*
|
2002-09-18 |
2004-03-18 |
Bone Care International, Inc. |
Multi-use vessels for vitamin D formulations
|
US7148211B2
(en)
*
|
2002-09-18 |
2006-12-12 |
Genzyme Corporation |
Formulation for lipophilic agents
|
WO2004053056A2
(en)
*
|
2002-09-24 |
2004-06-24 |
University Of Kentucky Research Foundation |
Nanoparticle-based vaccine delivery system containing adjuvant
|
EP1549767A4
(en)
|
2002-09-26 |
2006-06-07 |
Amgen Inc |
MODULATION OF FORKHEAD BOX O1A GENE EXPRESSION
|
US9809654B2
(en)
|
2002-09-27 |
2017-11-07 |
Vaccinex, Inc. |
Targeted CD1d molecules
|
US20050277611A1
(en)
*
|
2002-10-16 |
2005-12-15 |
Neopharm, Inc. |
Cationic cardiolipin analoges and its use thereof
|
US6863731B2
(en)
*
|
2002-10-18 |
2005-03-08 |
Controls Corporation Of America |
System for deposition of inert barrier coating to increase corrosion resistance
|
CN1747738B
(zh)
*
|
2002-10-29 |
2010-11-24 |
川塞夫有限公司 |
缓释抗感染剂
|
US7879351B2
(en)
*
|
2002-10-29 |
2011-02-01 |
Transave, Inc. |
High delivery rates for lipid based drug formulations, and methods of treatment thereof
|
JP3447009B1
(ja)
*
|
2002-10-29 |
2003-09-16 |
實 平垣 |
構築物用構成体およびその製造方法
|
US7718189B2
(en)
*
|
2002-10-29 |
2010-05-18 |
Transave, Inc. |
Sustained release of antiinfectives
|
TW200509968A
(en)
|
2002-11-01 |
2005-03-16 |
Elan Pharm Inc |
Prevention and treatment of synucleinopathic disease
|
US8506959B2
(en)
|
2002-11-01 |
2013-08-13 |
Neotope Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
AU2003287502B2
(en)
|
2002-11-05 |
2010-12-09 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
EP1560839A4
(en)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
CHIMERIC OLIGOMER COMPOUNDS AND THEIR USE IN GENE MODULATION
|
EP2336319A1
(en)
|
2002-11-13 |
2011-06-22 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
CA2505801A1
(en)
|
2002-11-13 |
2004-05-27 |
Rosanne Crooke |
Antisense modulation of apolipoprotein b expression
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
EP1903056A3
(en)
|
2002-12-10 |
2008-05-07 |
Idm Pharma, Inc. |
HLA-A1, -A2 -A3, -A24, -B7, and -B44 binding peptides comprising tumor associated antigen epitopes, and compositions thereof
|
AU2003293195A1
(en)
*
|
2002-12-23 |
2004-07-29 |
Vical Incorporated |
Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
|
PT2311848E
(pt)
|
2002-12-23 |
2013-10-03 |
Vical Inc |
Vacinas à base de polinucleótido optimizadas por codão contra a infecção do citomegalovírus humano
|
US7381422B2
(en)
*
|
2002-12-23 |
2008-06-03 |
Vical Incorporated |
Method for producing sterile polynucleotide based medicaments
|
US20040138154A1
(en)
*
|
2003-01-13 |
2004-07-15 |
Lei Yu |
Solid surface for biomolecule delivery and high-throughput assay
|
US20070269891A9
(en)
*
|
2003-01-13 |
2007-11-22 |
Yasunobu Tanaka |
Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
|
WO2004065551A2
(en)
*
|
2003-01-21 |
2004-08-05 |
Bristol-Myers Squibb Company |
Polynucleotide encoding a novel acyl coenzyme a, monoacylglycerol acyltransferase-3 (mgat3), and uses thereof
|
US7304161B2
(en)
|
2003-02-10 |
2007-12-04 |
Intrexon Corporation |
Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
|
WO2004072284A1
(en)
|
2003-02-11 |
2004-08-26 |
Antisense Therapeutics Ltd |
Modulation of insulin like growth factor i receptor expression
|
WO2004074314A2
(en)
*
|
2003-02-14 |
2004-09-02 |
University Of South Florida |
Chistosan-microparticles for ifn gene delivery
|
US7456315B2
(en)
|
2003-02-28 |
2008-11-25 |
Intrexon Corporation |
Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
CA2518475C
(en)
|
2003-03-07 |
2014-12-23 |
Alnylam Pharmaceuticals, Inc. |
Irna agents comprising asymmetrical modifications
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
WO2004092329A2
(en)
*
|
2003-04-08 |
2004-10-28 |
Galenica Pharmaceuticals, Inc. |
Semi-synthetic saponin analogs with carrier and immune stimulatory activities for dna and rna vaccines
|
WO2004094596A2
(en)
*
|
2003-04-16 |
2004-11-04 |
Wyeth Holdings Corporation |
Novel immunogenic compositions for the prevention and treatment of meningococcal disease
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
JP4597976B2
(ja)
|
2003-04-17 |
2010-12-15 |
アルナイラム ファーマシューティカルズ インコーポレイテッド |
修飾iRNA剤
|
AU2004231740A1
(en)
*
|
2003-04-17 |
2004-11-04 |
The Trustees Of Columbia University In The City Ofnew York |
Desmoglein 4 is a novel gene involved in hair growth
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
US8080642B2
(en)
|
2003-05-16 |
2011-12-20 |
Vical Incorporated |
Severe acute respiratory syndrome DNA compositions and methods of use
|
JP4846588B2
(ja)
*
|
2003-05-22 |
2011-12-28 |
モレキュラー、トランスファー、インコーポレイテッド |
核酸のトランスフェクションのための新規脂質
|
CN1984921B
(zh)
|
2003-06-03 |
2010-06-16 |
Isis药物公司 |
存活蛋白表达的调节
|
CN101396555A
(zh)
*
|
2003-06-04 |
2009-04-01 |
坎基股份有限公司 |
用于干扰素治疗的方法和组合物
|
CN1836042A
(zh)
|
2003-06-12 |
2006-09-20 |
原子核物理公司 |
用于基因沉默的hbv和hcv保守序列
|
US20060078560A1
(en)
*
|
2003-06-23 |
2006-04-13 |
Neopharm, Inc. |
Method of inducing apoptosis and inhibiting cardiolipin synthesis
|
US7261882B2
(en)
|
2003-06-23 |
2007-08-28 |
Reagents Of The University Of Colorado |
Methods for treating neuropathic pain by administering IL-10 polypeptides
|
JP4951338B2
(ja)
*
|
2003-07-16 |
2012-06-13 |
プロチバ バイオセラピューティクス インコーポレイティッド |
脂質に封入された干渉rna
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
EP2927318B1
(en)
|
2003-08-08 |
2020-05-20 |
Sangamo Therapeutics, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
US7330851B2
(en)
*
|
2003-08-18 |
2008-02-12 |
Eaglehawk, Limited |
Data security through dissembly of data elements or connections between elements
|
WO2005040388A2
(en)
*
|
2003-08-22 |
2005-05-06 |
Nucleonics Inc. |
Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments
|
WO2005023292A1
(en)
|
2003-09-03 |
2005-03-17 |
The General Hospital Corporation |
Methods of treating restenosis
|
WO2005026372A1
(en)
*
|
2003-09-15 |
2005-03-24 |
Protiva Biotherapeutics, Inc. |
Polyethyleneglycol-modified lipid compounds and uses thereof
|
EP2256200A3
(en)
|
2003-09-18 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E expression
|
CA2539439C
(en)
|
2003-09-19 |
2012-10-23 |
Sangamo Biosciences, Inc. |
Engineered zinc finger proteins for regulation of gene expression
|
JP2007507430A
(ja)
|
2003-10-10 |
2007-03-29 |
メディテック リサーチ リミテッド |
疾患の治療におけるヒアルロナン合成および分解の調節法
|
DE10347710B4
(de)
|
2003-10-14 |
2006-03-30 |
Johannes-Gutenberg-Universität Mainz |
Rekombinante Impfstoffe und deren Verwendung
|
AU2003284327A1
(en)
*
|
2003-10-22 |
2005-06-08 |
Neal Scott |
Charged liposomes/micelles with encapsulated medical compounds
|
US8016811B2
(en)
|
2003-10-24 |
2011-09-13 |
Altea Therapeutics Corporation |
Method for transdermal delivery of permeant substances
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
ITMI20032185A1
(it)
*
|
2003-11-12 |
2005-05-13 |
Chemi Spa |
Processo per la sintesi di lipidi cationici.
|
CA2747871C
(en)
|
2003-11-17 |
2018-04-10 |
Genentech, Inc. |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
US20050107318A1
(en)
*
|
2003-11-17 |
2005-05-19 |
Samuel Wadsworth |
Methods of treating diabetes and other blood sugar disorders
|
EP1696034A4
(en)
*
|
2003-12-19 |
2006-12-27 |
Dainippon Sumitomo Pharma Co |
NUCLEIC ACID TRANSFER METHOD
|
SE0303588D0
(sv)
|
2003-12-30 |
2003-12-30 |
Bioactive Polymers Ab C O Lund |
Surface protection of exposed biological tissues
|
US20050164271A1
(en)
|
2004-01-20 |
2005-07-28 |
Sanjay Bhanot |
Modulation of glucocorticoid receptor expression
|
US7468431B2
(en)
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
US7432057B2
(en)
*
|
2004-01-30 |
2008-10-07 |
Michigan State University |
Genetic test for PSE-susceptible turkeys
|
AU2005214091B2
(en)
*
|
2004-02-24 |
2010-08-12 |
Abbvie B.V. |
Method for determining the risk of developing a neurological disease
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
US8790919B2
(en)
|
2004-03-15 |
2014-07-29 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of RNA by RNase H
|
WO2005098049A2
(en)
|
2004-03-25 |
2005-10-20 |
California Institute Of Technology |
Hybridization chain reaction
|
DK1730280T3
(en)
*
|
2004-03-26 |
2019-02-04 |
Curis Inc |
RNA interference modulators for hedgehog signaling and applications thereof
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
ES2527528T3
(es)
|
2004-04-08 |
2015-01-26 |
Sangamo Biosciences, Inc. |
Métodos y composiciones para modular la contractilidad cardiaca
|
US20050260652A1
(en)
*
|
2004-04-15 |
2005-11-24 |
The General Hospital Corporation |
Compositions and methods that modulate RNA interference
|
CA2605574A1
(en)
|
2004-04-20 |
2005-11-03 |
Galapagos N.V. |
Methods, compositions and compound assays for inhibiting amyloid-beta protein production
|
MXPA06012162A
(es)
|
2004-04-27 |
2007-03-30 |
Galapagos Nv |
Metodos, agentes y ensayos de seleccion de compuestos para inducir diferenciacion de celulas de mamifero no diferenciadas, en osteoblastos.
|
US7935510B2
(en)
*
|
2004-04-30 |
2011-05-03 |
Intrexon Corporation |
Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
|
US7303881B2
(en)
*
|
2004-04-30 |
2007-12-04 |
Pds Biotechnology Corporation |
Antigen delivery compositions and methods of use
|
ES2967961T3
(es)
|
2004-05-03 |
2024-05-06 |
Ipsen Biopharm Ltd |
Liposomas útiles en la administración de fármacos
|
US20060024670A1
(en)
|
2004-05-18 |
2006-02-02 |
Luke Catherine J |
Influenza virus vaccine composition and methods of use
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
JP4764426B2
(ja)
|
2004-06-07 |
2011-09-07 |
プロチバ バイオセラピューティクス インコーポレイティッド |
カチオン性脂質および使用方法
|
CA2569664C
(en)
*
|
2004-06-07 |
2013-07-16 |
Protiva Biotherapeutics, Inc. |
Lipid encapsulated interfering rna
|
CA2569511A1
(en)
|
2004-06-14 |
2005-12-22 |
Galapagos N.V. |
Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases
|
EP2386856B1
(en)
|
2004-06-21 |
2013-07-24 |
Galapagos N.V. |
Methods and means for treatment of osteoarthritis
|
US7094775B2
(en)
|
2004-06-30 |
2006-08-22 |
Bone Care International, Llc |
Method of treating breast cancer using a combination of vitamin D analogues and other agents
|
CA2572439A1
(en)
*
|
2004-07-02 |
2006-01-12 |
Protiva Biotherapeutics, Inc. |
Immunostimulatory sirna molecules and uses therefor
|
CA2573176A1
(en)
*
|
2004-07-09 |
2006-01-19 |
Bc Cancer Agency |
Nup98-hox fusions for expansion of hemopoietic stem cells
|
US7604798B2
(en)
*
|
2004-07-15 |
2009-10-20 |
Northwestern University |
Methods and compositions for importing nucleic acids into cell nuclei
|
JP4772045B2
(ja)
|
2004-07-16 |
2011-09-14 |
アメリカ合衆国 |
Cmv/r核酸コンストラクトを含むaidsに対するワクチン
|
WO2006007712A1
(en)
*
|
2004-07-19 |
2006-01-26 |
Protiva Biotherapeutics, Inc. |
Methods comprising polyethylene glycol-lipid conjugates for delivery of therapeutic agents
|
MX2007001679A
(es)
|
2004-08-09 |
2007-05-23 |
Elan Pharm Inc |
Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica.
|
ATE483815T1
(de)
|
2004-08-23 |
2010-10-15 |
Alnylam Pharmaceuticals Inc |
Expressionskonstrukte mit mehreren rna-polymerase-iii-promotoren
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
CA2579677A1
(en)
|
2004-09-16 |
2006-03-30 |
Sangamo Biosciences, Inc. |
Compositions and methods for protein production
|
CA2824308A1
(en)
|
2004-09-24 |
2006-04-06 |
Alnylam Pharmaceuticals, Inc. |
Targeting opposite strand replication intermediates of single-stranded viruses by rnai
|
EP1799825B1
(en)
|
2004-10-05 |
2011-06-29 |
The California Institute of Technology |
Aptamer regulated nucleic acids and uses thereof
|
US7485468B2
(en)
|
2004-10-15 |
2009-02-03 |
Galapagos Bv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
|
WO2006044984A1
(en)
*
|
2004-10-18 |
2006-04-27 |
Mount Sinai School Of Medicine Of New York University |
Inhibition of tumor growth and metastasis by atf2-derived peptides
|
CN101048139A
(zh)
*
|
2004-10-28 |
2007-10-03 |
艾德克斯实验室公司 |
药物活性化合物的控释组合物
|
US20060147449A1
(en)
*
|
2004-11-15 |
2006-07-06 |
Brass Lawrence F |
Method of using CD100 (or Sema4D) to mediate platelet activation and inflammatory responses
|
EP2199298A1
(en)
*
|
2004-11-17 |
2010-06-23 |
Protiva Biotherapeutics Inc. |
Sirna silencing of Apolipoprotein B
|
DE102004057303A1
(de)
*
|
2004-11-26 |
2006-06-01 |
Merck Patent Gmbh |
Stabile Kristallmodifikationen von DOTAP Chlorid
|
WO2006060723A2
(en)
*
|
2004-12-03 |
2006-06-08 |
Vical Incorporated |
Methods for producing block copolymer/amphiphilic particles
|
DE602005027747D1
(de)
|
2004-12-22 |
2011-06-09 |
Alnylam Pharmaceuticals Inc |
Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen
|
US9034650B2
(en)
|
2005-02-02 |
2015-05-19 |
Intrexon Corporation |
Site-specific serine recombinases and methods of their use
|
CA2596506C
(en)
|
2005-02-09 |
2021-04-06 |
Avi Biopharma, Inc. |
Antisense composition and method for treating muscle atrophy
|
EP2314614B1
(en)
|
2005-02-28 |
2015-11-25 |
Sangamo BioSciences, Inc. |
Anti-angiogenic methods and compositions
|
US7727721B2
(en)
*
|
2005-03-08 |
2010-06-01 |
California Institute Of Technology |
Hybridization chain reaction amplification for in situ imaging
|
ZA200707490B
(en)
|
2005-03-10 |
2008-12-31 |
Genentech Inc |
Methods and compositions for modulatiing vascular integrity
|
US20090062184A1
(en)
*
|
2005-03-24 |
2009-03-05 |
Dainippon Sumitomo Pharma Co., Ltd. |
Fine particulate preparation comprising complex of nucleic acid molecule and collagen
|
AU2006230436B2
(en)
|
2005-03-31 |
2011-11-24 |
Calando Pharmaceuticals, Inc. |
Inhibitors of ribonucleotide reductase subunit 2 and uses thereof
|
US20070026061A1
(en)
*
|
2005-05-25 |
2007-02-01 |
Nahid Ali |
Liposomal formulation and use thereof
|
SI2816118T1
(sl)
|
2005-05-31 |
2019-01-31 |
The Regents Of The University Of Colorado, A Body Corporate |
Metode za dostavo genov
|
US8044022B2
(en)
|
2005-06-08 |
2011-10-25 |
Tadeusz Kolodka |
Hyaluronic acid binding peptides enhance host defense against pathogenic bacteria
|
WO2007005898A2
(en)
*
|
2005-07-05 |
2007-01-11 |
Cornell Research Foundation, Inc. |
Blocking leukocyte emigration and inflammation by interfering with cd99l2
|
AU2006272634B2
(en)
|
2005-07-26 |
2013-01-24 |
Sangamo Therapeutics, Inc. |
Targeted integration and expression of exogenous nucleic acid sequences
|
US20070054873A1
(en)
*
|
2005-08-26 |
2007-03-08 |
Protiva Biotherapeutics, Inc. |
Glucocorticoid modulation of nucleic acid-mediated immune stimulation
|
WO2007028147A2
(en)
*
|
2005-09-01 |
2007-03-08 |
Philadelphia Health & Education Corporation D.B.A. Drexel University College Of Medicin |
Identification of a prostatic intraepithelial neoplasia (pin)-specific gene and protein (pin-1) useful as a diagnostic treatment for prostate cancer
|
CN101268194A
(zh)
|
2005-09-20 |
2008-09-17 |
巴斯福植物科学有限公司 |
使用ta-siRNA调控基因表达的方法
|
DE102005046490A1
(de)
|
2005-09-28 |
2007-03-29 |
Johannes-Gutenberg-Universität Mainz |
Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
|
US7312079B1
(en)
|
2005-10-06 |
2007-12-25 |
Lexicon Pharmaceuticals, Inc. |
Variants of FAM3C
|
ATE526975T1
(de)
|
2005-10-07 |
2011-10-15 |
California Inst Of Techn |
Pkr-aktivierung mittels hybridisierungskettenreaktion
|
ES2577535T3
(es)
|
2005-10-21 |
2016-07-15 |
Regents Of The University Of California |
Mutaciones del oncogén de C-kit en melanomas
|
WO2007051303A1
(en)
|
2005-11-02 |
2007-05-10 |
Protiva Biotherapeutics, Inc. |
MODIFIED siRNA MOLECULES AND USES THEREOF
|
US7754679B2
(en)
*
|
2005-11-16 |
2010-07-13 |
Idexx Laboratories, Inc. |
Pharmaceutical compositions for the administration of aptamers
|
US8114440B2
(en)
|
2005-11-16 |
2012-02-14 |
Idexx Laboratories Inc. |
Pharmaceutical compositions for the administration of aptamers
|
WO2007062380A2
(en)
|
2005-11-21 |
2007-05-31 |
Isis Pharmaceuticals, Inc. |
Modulation of eif4e-bp2 expression
|
TWI461436B
(zh)
|
2005-11-25 |
2014-11-21 |
Kyowa Hakko Kirin Co Ltd |
人類cd134(ox40)之人類單株抗體及其製造及使用方法
|
US8226975B2
(en)
|
2005-12-08 |
2012-07-24 |
Insmed Incorporated |
Lipid-based compositions of antiinfectives for treating pulmonary infections and methods of use thereof
|
US10647960B2
(en)
*
|
2005-12-13 |
2020-05-12 |
The Trustees Of The University Of Pennsylvania |
Transcriptome transfer produces cellular phenotype conversion
|
WO2007070705A2
(en)
|
2005-12-15 |
2007-06-21 |
The Trustees Of The University Of Pennsylvania |
Cationic lipid-mediated vectors
|
US8669418B2
(en)
|
2005-12-22 |
2014-03-11 |
Vib Vzw |
Means and methods for mediating protein interference
|
BRPI0620125B1
(pt)
|
2005-12-22 |
2022-05-17 |
Vrije Universiteit Brussel |
Método para regulação de redução da função biológica de uma proteína, e método para isolar uma proteína de uma amostra
|
US20090221684A1
(en)
*
|
2005-12-22 |
2009-09-03 |
Trustees Of Boston University |
Molecules for Gene Delivery and Gene Therapy, and Methods of Use Thereof
|
EP2428227B1
(en)
|
2006-01-26 |
2016-06-22 |
Ionis Pharmaceuticals, Inc. |
Compositions and their uses directed to Huntingtin
|
US8278483B2
(en)
*
|
2006-02-07 |
2012-10-02 |
Council Of Scientific & Industrial Research |
Process for synthesis of glycomimicking cationic amphiphiles
|
AU2007221470B2
(en)
|
2006-02-10 |
2013-02-14 |
The University Of Cincinnati |
Phosphatase inhibitor Protein-1 as a regulator of cardiac function
|
EP2614839A3
(en)
|
2006-04-05 |
2015-01-28 |
Genentech, Inc. |
Method for using BOC/CDO to modulate hedgehog signaling
|
EP2015785A4
(en)
*
|
2006-04-24 |
2009-07-15 |
Shantha West Inc |
ANTIGEN AGRM2
|
MX2008014005A
(es)
|
2006-05-03 |
2009-01-27 |
Baltic Technology Dev Ltd |
Agentes antisentido que combinan un oligonucleotido modificado con base fuertemente unida y nucleasa artificial.
|
NZ572564A
(en)
|
2006-05-05 |
2011-10-28 |
Molecular Transfer Inc |
Novel reagents for transfection of eukaryotic cells
|
JP5266210B2
(ja)
|
2006-05-25 |
2013-08-21 |
サンガモ バイオサイエンシズ インコーポレイテッド |
改変開裂ハーフドメイン
|
GB0610636D0
(en)
|
2006-05-30 |
2006-07-05 |
Univ London |
Materials and complexes for the delivery of biologically-active material to cells
|
WO2008042024A2
(en)
|
2006-06-01 |
2008-04-10 |
Elan Pharmaceuticals, Inc. |
Neuroactive fragments of app
|
US7915399B2
(en)
*
|
2006-06-09 |
2011-03-29 |
Protiva Biotherapeutics, Inc. |
Modified siRNA molecules and uses thereof
|
US7572618B2
(en)
|
2006-06-30 |
2009-08-11 |
Bristol-Myers Squibb Company |
Polynucleotides encoding novel PCSK9 variants
|
US20080004410A1
(en)
*
|
2006-06-30 |
2008-01-03 |
Yu-Chin Lai |
Hydrophilic macromonomers having alpha,beta-conjugated carboxylic terminal group and medical devices incorporating same
|
JP5072275B2
(ja)
|
2006-07-03 |
2012-11-14 |
テルモ株式会社 |
閉鎖小胞の分離方法、製剤の製造方法および評価方法
|
US8198253B2
(en)
|
2006-07-19 |
2012-06-12 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to HBXIP
|
BRPI0714981A2
(pt)
*
|
2006-07-28 |
2013-08-13 |
Sanofi Aventis |
composiÇço, mÉtodo para fazer a mesma a qual compreende um inibidor que inibe a atividade de uma proteÍna do complexo iii, um veÍculo e um membro da superfamÍlia da fator de necrose de tumor, mÉtodo para conduzir um ensaio para determinar se um composto É um inibidor de atividade de supressço de tnf de uma proteÍna do complexo iii e uso de um composto
|
CN101588816B
(zh)
|
2006-10-19 |
2013-06-19 |
Csl有限公司 |
白介素-13受体α1的高亲和性抗体拮抗物
|
EP2068922B1
(en)
|
2006-10-19 |
2012-06-27 |
CSL Limited |
Anti-il-13r alpha 1 antibodies and their uses thereof
|
US8466154B2
(en)
*
|
2006-10-27 |
2013-06-18 |
The Board Of Regents Of The University Of Texas System |
Methods and compositions related to wrapping of dehydrons
|
WO2008058291A2
(en)
|
2006-11-09 |
2008-05-15 |
California Institute Of Technology |
Modular aptamer-regulated ribozymes
|
US20080199475A1
(en)
|
2006-11-27 |
2008-08-21 |
Patrys Limited |
Novel glycosylated peptide target in neoplastic cells
|
EP1938843A1
(en)
*
|
2006-12-19 |
2008-07-02 |
Novosom AG |
Lipids and lipid assemblies comrising transfection enhancer elements
|
AR064642A1
(es)
*
|
2006-12-22 |
2009-04-15 |
Wyeth Corp |
Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi
|
US8048998B2
(en)
*
|
2007-01-19 |
2011-11-01 |
Exiqon A/S |
Mediated cellular delivery of LNA oligonucleotides
|
EP2641971A1
(en)
|
2007-01-29 |
2013-09-25 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating protein expression
|
WO2009045469A2
(en)
|
2007-10-02 |
2009-04-09 |
Amgen Inc. |
Increasing erythropoietin using nucleic acids hybridizable to micro-rna and precursors thereof
|
EP2112930B1
(en)
|
2007-02-21 |
2017-01-11 |
Vaccinex, Inc. |
Modulation of nkt cell activity with antigen-loaded cdid molecules
|
BRPI0807635A2
(pt)
|
2007-02-22 |
2014-06-03 |
Genentech Inc |
Métodos para detecção de doença inflamatória intestinal
|
EP2118300B1
(en)
|
2007-02-23 |
2015-05-27 |
Prothena Biosciences Limited |
Prevention and treatment of synucleinopathic and amyloidogenic disease
|
HUE028731T2
(en)
|
2007-02-23 |
2016-12-28 |
Prothena Biosciences Ltd |
Prevention and treatment of synucleinopathic and amyloidogenic diseases
|
US8318921B2
(en)
|
2007-03-01 |
2012-11-27 |
California Institute Of Technology |
Triggered RNAi
|
US20080299182A1
(en)
*
|
2007-03-01 |
2008-12-04 |
Shuyuan Zhang |
Methods and formulations for topical gene therapy
|
US8877206B2
(en)
*
|
2007-03-22 |
2014-11-04 |
Pds Biotechnology Corporation |
Stimulation of an immune response by cationic lipids
|
DE102007015598A1
(de)
*
|
2007-03-29 |
2008-10-02 |
Heinrich-Heine-Universität Düsseldorf |
Verwendung von fluorhaltigen Verbindungen zu Diagnosezwecken mit Hilfe bildgebender Verfahren
|
US8895002B2
(en)
|
2007-04-09 |
2014-11-25 |
The General Hospital Corporation |
Hemojuvelin fusion proteins and uses thereof
|
LT2494993T
(lt)
|
2007-05-04 |
2018-12-27 |
Marina Biotech, Inc. |
Aminorūgščių lipidai ir jų panaudojimas
|
WO2008137717A1
(en)
|
2007-05-04 |
2008-11-13 |
Transave, Inc. |
Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
|
US9114081B2
(en)
|
2007-05-07 |
2015-08-25 |
Insmed Incorporated |
Methods of treating pulmonary disorders with liposomal amikacin formulations
|
US9119783B2
(en)
|
2007-05-07 |
2015-09-01 |
Insmed Incorporated |
Method of treating pulmonary disorders with liposomal amikacin formulations
|
US9333214B2
(en)
|
2007-05-07 |
2016-05-10 |
Insmed Incorporated |
Method for treating pulmonary disorders with liposomal amikacin formulations
|
US9217151B2
(en)
|
2007-05-16 |
2015-12-22 |
California Institute Of Technology |
Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
|
JP2010526542A
(ja)
|
2007-05-16 |
2010-08-05 |
エムエーティー・マルタ・アドヴァンスト・テクノロジーズ・リミテッド |
インフルエンザの治療および予防
|
EP2167480A2
(en)
|
2007-05-23 |
2010-03-31 |
Vical Incorporated |
Cationic lipids compositions and methods for enhancing immune responses to vaccines
|
CA2689137C
(en)
|
2007-05-29 |
2017-05-02 |
Intrexon Corporation |
Chiral diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
|
US20080312174A1
(en)
*
|
2007-06-05 |
2008-12-18 |
Nitto Denko Corporation |
Water soluble crosslinked polymers
|
EP2162747B1
(en)
|
2007-06-20 |
2014-04-30 |
Galapagos N.V. |
Molecular targets and methods to identify compounds for treating bone and joint degenerative diseases
|
US20090069266A1
(en)
*
|
2007-06-27 |
2009-03-12 |
Northwestern University |
Methods and compositions for nucleic acid transfer into cells
|
JP5770471B2
(ja)
|
2007-07-12 |
2015-08-26 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
α−1,6−フコシルトランスフェラーゼ(FUT8)遺伝子発現を不活性化するための方法および組成物
|
US20090082217A1
(en)
*
|
2007-07-16 |
2009-03-26 |
California Institute Of Technology |
Selection of nucleic acid-based sensor domains within nucleic acid switch platform
|
US8828960B2
(en)
*
|
2007-07-17 |
2014-09-09 |
Idexx Laboratories, Inc. |
Amino acid vitamin ester compositions for controlled delivery of pharmaceutically active compounds
|
KR20100049084A
(ko)
|
2007-08-23 |
2010-05-11 |
인트렉손 코포레이션 |
질병 진단을 위한 방법 및 조성물
|
US8367815B2
(en)
|
2007-08-28 |
2013-02-05 |
California Institute Of Technology |
Modular polynucleotides for ligand-controlled regulatory systems
|
US20120165387A1
(en)
|
2007-08-28 |
2012-06-28 |
Smolke Christina D |
General composition framework for ligand-controlled RNA regulatory systems
|
US8865667B2
(en)
|
2007-09-12 |
2014-10-21 |
California Institute Of Technology |
Higher-order cellular information processing devices
|
JP2010538647A
(ja)
*
|
2007-09-17 |
2010-12-16 |
ローム アンド ハース カンパニー |
植物における生理的応答を改変するための組成物および方法
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
NZ584848A
(en)
|
2007-09-28 |
2012-09-28 |
Intrexon Corp |
Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
|
AU2008308509B2
(en)
|
2007-10-04 |
2014-10-23 |
Zymogenetics, Inc. |
B7 family member zB7H6 and related compositions and methods
|
MX2010003720A
(es)
*
|
2007-10-08 |
2010-10-20 |
Intrexon Corp |
Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.
|
GB0720486D0
(en)
*
|
2007-10-19 |
2007-11-28 |
Univ Edinburgh |
Cationic lipids
|
CA2739011A1
(en)
*
|
2007-10-29 |
2009-05-07 |
The Regents Of The University Of California |
Osteoarthritis gene therapy
|
US8097712B2
(en)
|
2007-11-07 |
2012-01-17 |
Beelogics Inc. |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
|
DE102007056488A1
(de)
|
2007-11-22 |
2009-07-23 |
Biontex Laboratories Gmbh |
Steigerung von Transfektionseffizienzen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
DE102008016275A1
(de)
|
2008-03-28 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Blockierung des angeborenen Immunsystems
|
EP2212425A2
(de)
|
2007-11-22 |
2010-08-04 |
Biontex Laboratories Gmbh |
Verbesserung von transfektionsergebnissen nicht-viraler genliefersysteme durch beeinflussung des angeborenen immunsystems
|
DE102008023913A1
(de)
|
2008-05-16 |
2009-11-19 |
Biontex Laboratories Gmbh |
Verbesserung von Transfektionsergebnissen nicht-viraler Genliefersysteme durch Beeinflussung des angeborenen Immunsystems
|
EP4074344A1
(en)
|
2007-12-04 |
2022-10-19 |
Arbutus Biopharma Corporation |
Targeting lipids
|
US9029524B2
(en)
|
2007-12-10 |
2015-05-12 |
California Institute Of Technology |
Signal activated RNA interference
|
EP2584038B1
(en)
|
2007-12-11 |
2014-06-25 |
The Scripps Research Institute |
Compositions and methods related to mRNA translational enhancer elements
|
US8779088B2
(en)
|
2007-12-17 |
2014-07-15 |
Marfl Ab |
Vaccine for the treatment of Mycobacterium related disorders
|
CA2710713C
(en)
|
2007-12-27 |
2017-09-19 |
Protiva Biotherapeutics, Inc. |
Silencing of polo-like kinase expression using interfering rna
|
CA2710984C
(en)
|
2007-12-28 |
2018-05-29 |
Elan Pharmaceuticals, Inc. |
Treatment and prophylaxis of amyloidosis
|
WO2009102427A2
(en)
|
2008-02-11 |
2009-08-20 |
Rxi Pharmaceuticals Corp. |
Modified rnai polynucleotides and uses thereof
|
US8497364B2
(en)
*
|
2008-02-27 |
2013-07-30 |
California Institute Of Technology |
Triggered RNAi
|
US20110045001A1
(en)
*
|
2008-03-28 |
2011-02-24 |
Biontex Laboratories Gmbh |
Transfection results of non-viral gene delivery systems by influencing of the innate immune system
|
CA2720473A1
(en)
|
2008-04-04 |
2009-10-08 |
Calando Pharmaceuticals, Inc. |
Compositions and use of epas1 inhibitors
|
EP3604533A1
(en)
|
2008-04-11 |
2020-02-05 |
Arbutus Biopharma Corporation |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
CA2721333C
(en)
|
2008-04-15 |
2020-12-01 |
Protiva Biotherapeutics, Inc. |
Novel lipid formulations for nucleic acid delivery
|
AU2009236219B8
(en)
|
2008-04-15 |
2015-06-25 |
Arbutus Biopharma Corporation |
Silencing of CSN5 gene expression using interfering RNA
|
JP5971945B2
(ja)
|
2008-04-17 |
2016-08-17 |
ピーディーエス バイオテクノロジー コーポレイションPds Biotechnology Corporation |
カチオン性脂質の鏡像異性体による免疫応答の刺激
|
US20100021904A1
(en)
*
|
2008-05-21 |
2010-01-28 |
Pierce Niles A |
Shielded cross-linking probes
|
US8241854B2
(en)
*
|
2008-05-22 |
2012-08-14 |
California Institute Of Technology |
Triggered RNAi
|
US20100021901A1
(en)
*
|
2008-05-22 |
2010-01-28 |
Peng Yin |
Compositions and methods for detecting analytes
|
CA2726187A1
(en)
|
2008-05-30 |
2009-12-23 |
Yale University |
Targeted oligonucleotide compositions for modifying gene expression
|
CA2893175C
(en)
|
2008-06-10 |
2016-09-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for generation of bax- and bak-deficient cell lines
|
EP2303318A2
(en)
|
2008-06-20 |
2011-04-06 |
Wyeth LLC |
Compositions and methods of use of orf1358 from beta-hemolytic streptococcal strains
|
WO2010008582A2
(en)
|
2008-07-18 |
2010-01-21 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell drug delivery system
|
JP5908725B2
(ja)
|
2008-08-22 |
2016-04-26 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
標的一本鎖開裂および標的組込みのための方法、並びに組成物
|
EP2331141B1
(en)
|
2008-08-25 |
2016-01-06 |
Excaliard Pharmaceuticals, Inc. |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
WO2010029118A1
(en)
|
2008-09-11 |
2010-03-18 |
Biofocus Dpi B.V. |
Method for identifying compounds useful for increasing the functional activity and cell surface expression of cf-associated mutant cystic fibrosis transmembrane conductance regulator
|
EP2949752B1
(en)
|
2008-09-22 |
2017-12-20 |
RXi Pharmaceuticals Corporation |
Reduced size self-delivering rnai compounds
|
PL2350043T3
(pl)
|
2008-10-09 |
2014-09-30 |
Tekmira Pharmaceuticals Corp |
Ulepszone aminolipidy i sposoby dostarczania kwasów nukleinowych
|
EP2902013A1
(en)
|
2008-10-16 |
2015-08-05 |
Marina Biotech, Inc. |
Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics
|
RU2478396C2
(ru)
*
|
2008-11-05 |
2013-04-10 |
ВАЙЕТ ЭлЭлСи |
МНОГОКОМПОНЕНТНАЯ ИММУНОГЕННАЯ КОМПОЗИЦИЯ ДЛЯ ПРЕДУПРЕЖДЕНИЯ ЗАБОЛЕВАНИЯ, ВЫЗВАННОГО β-ГЕМОЛИТИЧЕСКИМИ СТРЕПТОКОККАМИ (БГС)
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
CA2745031C
(en)
|
2008-12-04 |
2018-08-14 |
Sangamo Biosciences, Inc. |
Genome editing in rats using zinc-finger nucleases
|
EP2370579B1
(en)
|
2008-12-04 |
2017-03-29 |
CuRNA, Inc. |
Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
|
KR20110091796A
(ko)
|
2008-12-04 |
2011-08-12 |
오피케이오 큐알엔에이, 엘엘씨 |
종양 억제 유전자에 대한 천연 안티센스 전사체의 억제에 의해 종양 억제 유전자 관련된 질환의 치료
|
CN108042560A
(zh)
|
2008-12-04 |
2018-05-18 |
库尔纳公司 |
通过抑制针对沉默调节蛋白1的天然反义转录物来治疗沉默调节蛋白1相关的疾病
|
WO2010078536A1
(en)
|
2009-01-05 |
2010-07-08 |
Rxi Pharmaceuticals Corporation |
Inhibition of pcsk9 through rnai
|
US20100233270A1
(en)
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
FR2941152B1
(fr)
*
|
2009-01-20 |
2013-10-18 |
Centre Nat Rech Scient |
Vecteurs comprenant une macromolecule anionique et un lipide cationique pour l'administration de petits acides nucleiques.
|
US8551945B2
(en)
|
2009-02-04 |
2013-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating neuropathies
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
KR101682735B1
(ko)
|
2009-02-12 |
2016-12-06 |
큐알엔에이, 인크. |
뇌 유래된 신경영양성 인자 (bdnf)에 대한 자연 안티센스 전사체의 저해에 의한 뇌 유래된 신경영양성 인자 (bdnf) 관련된 질환의 치료
|
JP6066035B2
(ja)
|
2009-02-12 |
2017-01-25 |
クルナ・インコーポレーテッド |
グリア細胞由来神経栄養因子(gdnf)関連疾病の、gdnfに対する天然アンチセンス転写物の抑制による治療
|
WO2010096561A1
(en)
|
2009-02-18 |
2010-08-26 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Synthetic hiv/siv gag proteins and uses thereof
|
US8329882B2
(en)
|
2009-02-18 |
2012-12-11 |
California Institute Of Technology |
Genetic control of mammalian cells with synthetic RNA regulatory systems
|
US20120004160A1
(en)
|
2009-02-19 |
2012-01-05 |
Glaxo Group Ltd. |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
JP2012518181A
(ja)
|
2009-02-19 |
2012-08-09 |
ガラパゴス・ナムローゼ・フェンノートシャップ |
炎症を包含する疾患の診断及び治療に有用な同定方法及び化合物
|
EP2398481A2
(en)
|
2009-02-19 |
2011-12-28 |
Galapagos N.V. |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
US20110319317A1
(en)
|
2009-03-04 |
2011-12-29 |
Opko Curna, Llc |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt1
|
CN102482677B
(zh)
|
2009-03-16 |
2017-10-17 |
库尔纳公司 |
通过抑制nrf2的天然反义转录物治疗核因子(红细胞衍生2)‑样2(nrf2)相关疾病
|
JP5904935B2
(ja)
|
2009-03-17 |
2016-04-20 |
クルナ・インコーポレーテッド |
デルタ様1ホモログ(dlk1)に対する天然アンチセンス転写物の抑制によるdlk1関連疾患の治療
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
WO2010115825A2
(en)
|
2009-03-31 |
2010-10-14 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
JP2012522977A
(ja)
|
2009-04-01 |
2012-09-27 |
ガラパゴス・ナムローゼ・フェンノートシャップ |
変形性関節症の治療のための方法及び手段
|
US9145555B2
(en)
|
2009-04-02 |
2015-09-29 |
California Institute Of Technology |
Integrated—ligand-responsive microRNAs
|
CA2756833C
(en)
|
2009-04-09 |
2019-11-19 |
Sangamo Biosciences, Inc. |
Targeted integration into stem cells
|
ES2571235T3
(es)
|
2009-04-10 |
2016-05-24 |
Kyowa Hakko Kirin Co Ltd |
Procedimiento para el tratamiento de un tumor sanguíneo que utiliza el anticuerpo anti-TIM-3
|
EP2419121B1
(en)
|
2009-04-17 |
2018-07-18 |
New York University |
Peptides targeting tnf family receptors and antagonizing tnf action, compositions, methods and uses thereof
|
EP3248618A1
(en)
|
2009-04-22 |
2017-11-29 |
Massachusetts Institute Of Technology |
Innate immune suppression enables repeated delivery of long rna molecules
|
US20100273203A1
(en)
*
|
2009-04-23 |
2010-10-28 |
Board Of Trustees Of The University Of Arkansas |
Methods and compositions for detecting metabolites
|
CN102459342B
(zh)
|
2009-04-27 |
2015-01-07 |
协和发酵麒麟株式会社 |
用于治疗血液肿瘤的抗il-3ra抗体
|
US8044215B2
(en)
*
|
2009-04-29 |
2011-10-25 |
Juvaris Biotherapeutics, Inc. |
Methods for the preparation of amphillic nitrogen containing imidazolinium derivative compounds
|
EP2424987B1
(en)
|
2009-05-01 |
2017-11-15 |
CuRNA, Inc. |
Treatment of hemoglobin (hbf/hbg) related diseases by inhibition of natural antisense transcript to hbf/hbg
|
CA2761142C
(en)
|
2009-05-06 |
2021-06-08 |
Opko Curna, Llc |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
CA2761152A1
(en)
|
2009-05-06 |
2010-11-11 |
Opko Curna, Llc |
Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
|
CN102985548B
(zh)
|
2009-05-16 |
2016-10-26 |
崔坤元 |
用于递送治疗分子的包含阳离子两亲物和辅脂质的组合物
|
KR101749356B1
(ko)
|
2009-05-18 |
2017-07-06 |
큐알엔에이, 인크. |
재편성 인자에 대한 천연 안티센스 전사체의 억제에 의한 재편성 인자 관련된 질환의 치료
|
KR101703695B1
(ko)
|
2009-05-22 |
2017-02-08 |
큐알엔에이, 인크. |
전사 인자 e3(tfe3)에 대한 천연 안티센스 전사체의 억제에 의해 tfe3 및 인슐린 수용체 기질 2(irs2)의 치료
|
EP2435571B1
(en)
|
2009-05-28 |
2016-12-14 |
CuRNA, Inc. |
Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene
|
AU2010260145B2
(en)
|
2009-06-15 |
2015-08-20 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of Myotubular Myopathy using chimeric polypeptides comprising myotubularin 1 (MTM1) polypeptides
|
KR101801404B1
(ko)
|
2009-06-16 |
2017-12-20 |
큐알엔에이, 인크. |
콜라겐 유전자에 대한 천연 안티센스 전사체의 억제에 의한 콜라겐 유전자 관련된 질환의 치료
|
KR101702689B1
(ko)
|
2009-06-16 |
2017-02-06 |
큐알엔에이, 인크. |
Pon1에 대한 천연 안티센스 전사체의 억제에 의한 파라옥소나제 1(pon1) 관련된 질환의 치료
|
ES2618894T3
(es)
|
2009-06-24 |
2017-06-22 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con el receptor del factor de necrosis tumoral 2 (tnfr2) por inhibición del transcrito natural antisentido para tnfr2
|
CN102482672B
(zh)
|
2009-06-26 |
2016-11-09 |
库尔纳公司 |
通过抑制唐氏综合征基因的天然反义转录物治疗唐氏综合征基因相关疾病
|
WO2011000106A1
(en)
|
2009-07-01 |
2011-01-06 |
Protiva Biotherapeutics, Inc. |
Improved cationic lipids and methods for the delivery of therapeutic agents
|
JP5766188B2
(ja)
|
2009-07-01 |
2015-08-19 |
プロチバ バイオセラピューティクス インコーポレイティッド |
固形腫瘍に治療剤を送達するための脂質製剤
|
US9018187B2
(en)
|
2009-07-01 |
2015-04-28 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
BR212012000255U2
(pt)
|
2009-07-09 |
2015-11-03 |
Marina Biotech Inc |
lipossomas anfotéricos compreendendo imino lípidos.
|
US8716464B2
(en)
|
2009-07-20 |
2014-05-06 |
Thomas W. Geisbert |
Compositions and methods for silencing Ebola virus gene expression
|
WO2011016840A2
(en)
|
2009-07-28 |
2011-02-10 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating trinucleotide repeat disorders
|
ES2550202T3
(es)
|
2009-08-03 |
2015-11-05 |
Recombinetics, Inc. |
Métodos y composiciones para la modificación dirigida de genes
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
CN102762731B
(zh)
|
2009-08-05 |
2018-06-22 |
库尔纳公司 |
通过抑制针对胰岛素基因(ins)的天然反义转录物来治疗胰岛素基因(ins)相关的疾病
|
US8410064B2
(en)
*
|
2009-08-24 |
2013-04-02 |
The Board Of Trustees Of The University Of Arkansas |
Classical cannabinoid metabolites and methods of use thereof
|
EP2470657B1
(en)
|
2009-08-25 |
2019-10-23 |
CuRNA, Inc. |
Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
|
DK2473522T3
(en)
|
2009-09-02 |
2016-11-28 |
Genentech Inc |
Smoothened MUTANT AND METHODS OF USING THE SAME
|
EP2480668A2
(en)
|
2009-09-23 |
2012-08-01 |
Protiva Biotherapeutics Inc. |
Compositions and methods for silencing genes expressed in cancer
|
EP2488210A4
(en)
|
2009-10-12 |
2014-04-30 |
Smith Holdings Llc |
METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING IN VITO OR IN VITRO-ADMINISTERED OLIGONUCLEOTIDE MEDICAMENTS
|
US8962584B2
(en)
|
2009-10-14 |
2015-02-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Compositions for controlling Varroa mites in bees
|
KR20120105446A
(ko)
|
2009-10-22 |
2012-09-25 |
제넨테크, 인크. |
대식세포-자극 단백질의 헵신 활성화를 조정하기 위한 방법 및 조성물
|
WO2011056682A1
(en)
|
2009-10-27 |
2011-05-12 |
The University Of British Columbia |
Reverse head group lipids, lipid particle compositions comprising reverse headgroup lipids, and methods for the delivery of nucleic acids
|
WO2011056234A1
(en)
|
2009-11-06 |
2011-05-12 |
Fibrogen, Inc. |
Treatment for radiation-induced disorders
|
US9556272B2
(en)
|
2009-11-11 |
2017-01-31 |
The Trustees Of The University Of Pennsylvania |
Anti-TEM1 antibodies and uses thereof
|
NZ599707A
(en)
|
2009-11-30 |
2014-07-25 |
Genentech Inc |
Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid2 )
|
NZ716192A
(en)
|
2009-12-01 |
2017-07-28 |
Shire Human Genetic Therapies |
Delivery of mrna for the augmentation of proteins and enzymes in human genetic diseases
|
AU2010329847A1
(en)
|
2009-12-11 |
2012-07-26 |
Genecode As |
Methods of facilitating neural cell survival using GDNF family ligand (GFL) mimetics or RET signaling pathway activators
|
RU2639550C2
(ru)
|
2009-12-16 |
2017-12-21 |
Курна, Инк. |
Лечение заболеваний, связанных с сайт-1 мембраносвязанной пептидазой транскрипционных факторов (mbtps1), путем ингибирования природного антисмыслового транскрипта к mbtps1
|
EP2515947B1
(en)
|
2009-12-23 |
2021-10-06 |
CuRNA, Inc. |
Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
|
RU2609631C2
(ru)
|
2009-12-23 |
2017-02-02 |
Курна, Инк. |
Лечение заболеваний, связанных с фактором роста гепатоцитов (фрг), посредством ингибирования природного антисмыслового транскрипта к фрг
|
KR101838305B1
(ko)
|
2009-12-29 |
2018-03-13 |
큐알엔에이, 인크. |
NRF1(Nuclear Respiratory Factor 1)에 대한 천연 안티센스 전사체의 억제에 의한 핵 호흡 인자 1 관련된 질환의 치료
|
CN102770540B
(zh)
|
2009-12-29 |
2017-06-23 |
库尔纳公司 |
通过抑制肿瘤蛋白63(p63)的天然反义转录物而治疗p63相关疾病
|
CN102906264B
(zh)
|
2010-01-04 |
2017-08-04 |
库尔纳公司 |
通过抑制干扰素调节因子8(irf8)的天然反义转录物而治疗irf8相关疾病
|
WO2011085066A2
(en)
|
2010-01-06 |
2011-07-14 |
Curna, Inc. |
Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
|
US9200277B2
(en)
|
2010-01-11 |
2015-12-01 |
Curna, Inc. |
Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG
|
EP2525808A2
(en)
|
2010-01-19 |
2012-11-28 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for male reproductive disorders
|
KR101866578B1
(ko)
|
2010-01-22 |
2018-06-11 |
다우 아그로사이언시즈 엘엘씨 |
표적화된 게놈 교체
|
ES2671877T3
(es)
|
2010-01-25 |
2018-06-11 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la RNASA (H1) mediante inhibición del transcrito antisentido natural a RNASA H1
|
JP6137596B2
(ja)
|
2010-02-08 |
2017-05-31 |
サンガモ セラピューティクス, インコーポレイテッド |
遺伝子操作された切断ハーフドメイン
|
CA2788850C
(en)
|
2010-02-09 |
2019-06-25 |
Sangamo Biosciences, Inc. |
Targeted genomic modification with partially single-stranded donor molecules
|
KR101838308B1
(ko)
|
2010-02-22 |
2018-03-13 |
큐알엔에이, 인크. |
피롤린-5-카르복실레이트 환원효소 1(pycr1)에 대한 천연 안티센스 전사체의 억제에 의한 pycr1과 관련된 질환의 치료
|
WO2011106297A2
(en)
|
2010-02-23 |
2011-09-01 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
WO2011109427A2
(en)
|
2010-03-01 |
2011-09-09 |
Alnylam Pharmaceuticals, Inc. |
Improving the biological activity of sirna through modulation of its thermodynamic profile
|
ES2809679T3
(es)
|
2010-03-08 |
2021-03-05 |
Monsanto Technology Llc |
Moléculas polinucleotídicas para la regulación génica en plantas
|
AU2011227050B2
(en)
|
2010-03-19 |
2016-12-08 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
TW201823463A
(zh)
|
2010-03-23 |
2018-07-01 |
美商英翠克頌公司 |
條件性表現治療性蛋白質之載體、包含該載體之宿主細胞及彼等之用途
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
CN110042099A
(zh)
|
2010-03-24 |
2019-07-23 |
菲奥医药公司 |
皮肤与纤维化症候中的rna干扰
|
RU2615143C2
(ru)
|
2010-03-24 |
2017-04-04 |
Адвирна |
Самодоставляющие PHKi соединения уменьшенного размера
|
EP2549859B1
(en)
|
2010-03-24 |
2017-06-21 |
Institut National de la Santé et de la Recherche Medicale |
Primate model from the family Cercopithecidae infected by a HBV strain of human genotype
|
ES2625406T3
(es)
|
2010-03-25 |
2017-07-19 |
Oregon Health & Science University |
Glicoproteínas de CMV y vectores recombinantes
|
WO2011120023A1
(en)
|
2010-03-26 |
2011-09-29 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting survivin gene expression uses thereof
|
US8883218B2
(en)
*
|
2010-03-26 |
2014-11-11 |
The Board Of Trustees Of The University Of Arkansas |
Anti-cancer nanoparticle compositions and methods of use
|
KR101900962B1
(ko)
|
2010-04-09 |
2018-09-20 |
큐알엔에이, 인크. |
섬유아세포 성장 인자 21 (fgf21)에 대한 자연 안티센스 전사체의 저해에 의한 섬유아세포 성장 인자 21 (fgf21) 관련된 질환의 치료
|
US8790621B2
(en)
*
|
2010-04-12 |
2014-07-29 |
Iowa State University Research Foundation, Inc. |
Nanoparticles and nanoparticle compositions
|
US20130116171A1
(en)
|
2010-04-16 |
2013-05-09 |
Salk Institute For Biological Studies |
Methods for treating metabolic disorders using fgf
|
WO2011133584A2
(en)
|
2010-04-19 |
2011-10-27 |
Marina Biotech, Inc. |
Nucleic acid compounds for inhibiting hras gene expression and uses thereof
|
WO2011139843A2
(en)
|
2010-04-28 |
2011-11-10 |
Marina Biotech, Inc. |
Multi-sirna compositions for reducing gene expression
|
US20130129811A1
(en)
|
2010-04-28 |
2013-05-23 |
Takeshi Kuboyama |
Cationic lipid
|
EP2567951B1
(en)
|
2010-04-28 |
2018-09-19 |
Kyowa Hakko Kirin Co., Ltd. |
Cationic lipid
|
PT2563920T
(pt)
|
2010-04-29 |
2017-05-26 |
Ionis Pharmaceuticals Inc |
Modulação da expressão de transtirretina
|
CN107090045A
(zh)
|
2010-05-03 |
2017-08-25 |
霍夫曼-拉罗奇有限公司 |
用于肿瘤诊断和治疗的组合物和方法
|
US9089588B2
(en)
|
2010-05-03 |
2015-07-28 |
Curna, Inc. |
Treatment of sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a sirtuin (SIRT)
|
DK2569430T3
(en)
|
2010-05-12 |
2019-02-04 |
Univ Columbia |
PROCEDURES FOR MANUFACTURING ENTEROENDOCRIN CELLS WHICH MANUFACTURE AND SECRET INSULIN
|
US10077232B2
(en)
|
2010-05-12 |
2018-09-18 |
Arbutus Biopharma Corporation |
Cyclic cationic lipids and methods of use
|
EP2569276B1
(en)
|
2010-05-12 |
2021-02-24 |
Arbutus Biopharma Corporation |
Novel cationic lipids and methods of use thereof
|
TWI531370B
(zh)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
藉由抑制par4天然反股轉錄本治療par4相關疾病
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス, インコーポレイテッド |
新規のdna結合タンパク質及びその使用
|
US8658780B2
(en)
|
2010-05-18 |
2014-02-25 |
California Institute Of Technology |
Triggered covalent probes for imaging and silencing genetic expression
|
DK2576783T3
(en)
|
2010-05-26 |
2018-03-12 |
Curna Inc |
TREATMENT OF ATONAL HOMOLOGY 1- (ATOH1) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS AT ATOH1
|
CA2802017A1
(en)
|
2010-06-09 |
2011-12-15 |
Zymogenetics, Inc. |
Dimeric vstm3 fusion proteins and related compositions and methods
|
US20130164380A1
(en)
|
2010-06-17 |
2013-06-27 |
Actogenix Nv |
Compositions and methods for treating inflammatory conditions
|
WO2012000104A1
(en)
|
2010-06-30 |
2012-01-05 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
ES2586580T3
(es)
|
2010-07-06 |
2016-10-17 |
Glaxosmithkline Biologicals Sa |
Inmunización de mamíferos grandes con dosis bajas de ARN
|
PL2590626T3
(pl)
|
2010-07-06 |
2016-04-29 |
Glaxosmithkline Biologicals Sa |
Liposomy z lipidami o korzystnej wartości pka do dostarczania rna
|
EP3449910A1
(en)
|
2010-07-06 |
2019-03-06 |
GlaxoSmithKline Biologicals S.A. |
Cationic oil-in-water emulsions
|
EP2590670B1
(en)
|
2010-07-06 |
2017-08-23 |
GlaxoSmithKline Biologicals SA |
Methods of raising an immune response by delivery of rna
|
EP2593547B1
(en)
|
2010-07-14 |
2017-11-15 |
CuRNA, Inc. |
Treatment of discs large homolog (dlg) related diseases by inhibition of natural antisense transcript to dlg
|
US8877438B2
(en)
|
2010-07-20 |
2014-11-04 |
California Institute Of Technology |
Self-assembled polynucleotide structure
|
US9834439B2
(en)
|
2010-07-20 |
2017-12-05 |
California Institute Of Technology |
Biomolecular self-assembly
|
US8962241B2
(en)
|
2010-07-20 |
2015-02-24 |
California Institute Of Technology |
Triggered molecular geometry based bioimaging probes
|
US9057057B2
(en)
|
2010-07-27 |
2015-06-16 |
The Johns Hopkins University |
Obligate heterodimer variants of foki cleavage domain
|
EP3246044B2
(en)
|
2010-08-23 |
2024-04-10 |
Wyeth LLC |
Stable formulations of neisseria meningitidis rlp2086 antigens
|
ES2938866T3
(es)
|
2010-08-31 |
2023-04-17 |
Glaxosmithkline Biologicals Sa |
Liposomas pegilados para la administración de ARN que codifica para inmunógeno
|
ES2864635T3
(es)
|
2010-09-10 |
2021-10-14 |
Wyeth Llc |
Variantes no lipidadas de antígenos ORF2086 de Neisseria meningitidis
|
EP2616431B1
(en)
|
2010-09-14 |
2016-11-09 |
Council of Scientific & Industrial Research |
Novel cationic amphiphiles with mannose-mimicking head-groups and a process for the preparation thereof
|
EP2622090B1
(en)
|
2010-09-27 |
2019-06-19 |
Sangamo Therapeutics, Inc. |
Compositions for inhibiting viral entry into cells
|
US8481680B2
(en)
|
2010-10-05 |
2013-07-09 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
US8993533B2
(en)
|
2010-10-06 |
2015-03-31 |
Curna, Inc. |
Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4
|
JP2013544504A
(ja)
|
2010-10-11 |
2013-12-19 |
ノバルティス アーゲー |
抗原送達プラットフォーム
|
CA2815212A1
(en)
|
2010-10-22 |
2012-04-26 |
Curna, Inc. |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
RU2611195C2
(ru)
|
2010-10-27 |
2017-02-21 |
Курна, Инк. |
Лечение заболеваний, связанных с интерферон- связанным регулятором развития 1 (ifrd1), путем ингибирования природного антисмыслового транскрипта к ifrd1
|
WO2012061811A2
(en)
|
2010-11-05 |
2012-05-10 |
Fibrogen, Inc. |
Treatment method for lung remodeling diseases
|
KR102010598B1
(ko)
|
2010-11-23 |
2019-08-13 |
큐알엔에이, 인크. |
Nanog에 대한 자연 안티센스 전사체의 저해에 의한 nanog 관련된 질환의 치료
|
CA2819635A1
(en)
|
2010-12-01 |
2012-06-07 |
Spinal Modulation, Inc. |
Directed delivery of agents to neural anatomy
|
EP2648706A4
(en)
|
2010-12-06 |
2014-07-23 |
Penn State Res Found |
COMPOSITIONS AND METHODS RELATING TO PROLIFERATIVE DISEASES
|
CN107090441A
(zh)
|
2010-12-09 |
2017-08-25 |
巴斯德研究所 |
用于获得高产量重组蛋白表达的基于mgmt的方法
|
US9095598B2
(en)
|
2010-12-28 |
2015-08-04 |
The Board Of Trustees Of The University Of Arkansas |
Stilbenoid derivatives and their uses
|
US9428565B2
(en)
|
2011-01-31 |
2016-08-30 |
The General Hospital Corporation |
Treatment and bioluminescent visualization using multimodal TRAIL molecules
|
BR112013019803A2
(pt)
|
2011-02-02 |
2019-06-11 |
Excaliard Pharmaceuticals Inc |
método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf)
|
WO2012109495A1
(en)
|
2011-02-09 |
2012-08-16 |
Metabolic Solutions Development Company, Llc |
Cellular targets of thiazolidinediones
|
EP2492279A1
(en)
|
2011-02-25 |
2012-08-29 |
Laboratorios Del. Dr. Esteve, S.A. |
Rapid immunogen selection method using lentiviral display
|
EP3450568A3
(en)
|
2011-03-04 |
2019-04-24 |
Intrexon Corporation |
Vectors conditionally expressing protein
|
AU2012236099A1
(en)
|
2011-03-31 |
2013-10-03 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
US9458456B2
(en)
|
2011-04-01 |
2016-10-04 |
University Of South Alabama |
Methods and compositions for the diagnosis, classification, and treatment of cancer
|
JP5951752B2
(ja)
|
2011-04-13 |
2016-07-13 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
Ptp1b発現のアンチセンス調節
|
US20130101628A1
(en)
*
|
2011-04-29 |
2013-04-25 |
Northwestern University |
Novel vegf mimetic peptide-based scaffolds for therapeutic angiogenesis and methods for their use
|
MX361369B
(es)
*
|
2011-05-20 |
2018-12-05 |
Merck Patent Gmbh |
Modificaciones cristalinas estables de cloruro de dotap.
|
HUE062102T2
(hu)
|
2011-05-24 |
2023-09-28 |
BioNTech SE |
Individualizált vakcinák a rák ellen
|
DK2717893T3
(da)
|
2011-06-08 |
2019-07-22 |
Translate Bio Inc |
Lipid nanopartikelsammensætninger og fremgangsmåder til mrna-levering
|
JP6188686B2
(ja)
|
2011-06-09 |
2017-08-30 |
カッパーアールエヌエー,インコーポレイテッド |
フラタキシン(fxn)への天然アンチセンス転写物の阻害によるfxn関連疾患の治療
|
SI2691530T1
(en)
|
2011-06-10 |
2018-08-31 |
Oregon Health & Science University |
CMV glycoproteins and recombinant vectors
|
EP2721156B1
(en)
|
2011-06-16 |
2016-12-21 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
EP2723758B1
(en)
|
2011-06-21 |
2018-06-20 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compostions and methods of use thereof
|
WO2013006838A1
(en)
|
2011-07-06 |
2013-01-10 |
Novartis Ag |
Immunogenic combination compositions and uses thereof
|
MX350198B
(es)
|
2011-07-06 |
2017-08-30 |
Novartis Ag |
Emulsiones aceite en agua que contienen acidos nucleicos.
|
JP6120839B2
(ja)
|
2011-07-06 |
2017-04-26 |
ノバルティス アーゲー |
カチオン性水中油型エマルジョン
|
JP6214530B2
(ja)
|
2011-07-15 |
2017-10-18 |
ザ ジェネラル ホスピタル コーポレイション |
転写活性化因子様エフェクターの組立て方法
|
EP2546358A1
(en)
|
2011-07-15 |
2013-01-16 |
Laboratorios Del. Dr. Esteve, S.A. |
Methods and reagents for efficient control of HIV progression
|
AU2012333134B2
(en)
|
2011-07-22 |
2017-05-25 |
John Paul Guilinger |
Evaluation and improvement of nuclease cleavage specificity
|
US20130189754A1
(en)
|
2011-09-12 |
2013-07-25 |
International Aids Vaccine Initiative |
Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
|
US10829828B2
(en)
|
2011-09-13 |
2020-11-10 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
US10760086B2
(en)
|
2011-09-13 |
2020-09-01 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
US10806146B2
(en)
|
2011-09-13 |
2020-10-20 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
EP2755466A4
(en)
|
2011-09-13 |
2015-04-15 |
Monsanto Technology Llc |
METHODS AND COMPOSITIONS FOR CONTROLLING WEEDS
|
SG10201703771WA
(en)
|
2011-09-19 |
2017-06-29 |
Axon Neuroscience Se |
Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
|
WO2013043569A1
(en)
|
2011-09-20 |
2013-03-28 |
Vical Incorporated |
Synergistic anti-tumor efficacy using alloantigen combination immunotherapy
|
CA2849273C
(en)
|
2011-09-20 |
2020-07-21 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of gcgr expression
|
EP2760463B1
(en)
|
2011-09-20 |
2018-11-21 |
The University of North Carolina At Chapel Hill |
Regulation of sodium channels by plunc proteins
|
US9150847B2
(en)
|
2011-09-21 |
2015-10-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for regulation of transgene expression
|
US20130085139A1
(en)
|
2011-10-04 |
2013-04-04 |
Royal Holloway And Bedford New College |
Oligomers
|
WO2013053765A1
(en)
|
2011-10-11 |
2013-04-18 |
Proyecto De Biomedicina Cima, S.L. |
A non-human animal model of mucosa-associated lymphoid tissue (malt) lymphoma
|
AU2012328680A1
(en)
|
2011-10-25 |
2014-05-01 |
Ionis Pharmaceuticals, Inc. |
Antisense modulation of GCCR expression
|
US9402894B2
(en)
|
2011-10-27 |
2016-08-02 |
International Aids Vaccine Initiative |
Viral particles derived from an enveloped virus
|
JP2013095755A
(ja)
|
2011-11-02 |
2013-05-20 |
Kyowa Hakko Kirin Co Ltd |
カチオン性脂質
|
DK3366775T3
(da)
|
2011-11-18 |
2022-08-01 |
Alnylam Pharmaceuticals Inc |
Modificerede rnai-midler
|
DK3301177T3
(da)
|
2011-11-18 |
2020-06-15 |
Alnylam Pharmaceuticals Inc |
Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme
|
EP2788316B1
(en)
*
|
2011-12-07 |
2019-04-24 |
Alnylam Pharmaceuticals, Inc. |
Branched alkyl and cycloalkyl terminated biodegradable lipids for the delivery of active agents
|
WO2013086354A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Biodegradable lipids for the delivery of active agents
|
JP6215223B2
(ja)
|
2011-12-09 |
2017-10-18 |
アンスティテュ・パストゥール |
マルチプレックス免疫スクリーニングアッセイ
|
JP6182457B2
(ja)
|
2011-12-12 |
2017-08-16 |
協和発酵キリン株式会社 |
カチオン性脂質を含有するドラックデリバリーシステムのための脂質ナノ粒子
|
EP2792368A4
(en)
|
2011-12-12 |
2015-09-30 |
Kyowa Hakko Kirin Co Ltd |
LIPID NANOPARTICLES WITH COMBINATIONS OF CATIONIC LIPIDES
|
DK2791160T3
(da)
*
|
2011-12-16 |
2022-05-30 |
Modernatx Inc |
Modificerede mrna-sammensætninger
|
US9035039B2
(en)
|
2011-12-22 |
2015-05-19 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing SMAD4
|
US9073960B2
(en)
|
2011-12-22 |
2015-07-07 |
Alios Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
WO2013103401A1
(en)
|
2012-01-06 |
2013-07-11 |
University Of South Alabama |
Methods and compositions for the treatment of cancer
|
JP6416627B2
(ja)
|
2012-01-09 |
2018-10-31 |
セルピン ファーマ リミテッド ライアビリティ カンパニー |
ペプチドおよびその使用法
|
KR102075810B1
(ko)
|
2012-02-24 |
2020-02-10 |
아뷰터스 바이오파마 코포레이션 |
트리알킬 양이온성 지질 및 그의 사용 방법
|
WO2013130824A1
(en)
|
2012-02-29 |
2013-09-06 |
Sangamo Biosciences, Inc. |
Methods and compositions for treating huntington's disease
|
SA115360586B1
(ar)
|
2012-03-09 |
2017-04-12 |
فايزر انك |
تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها
|
MY167723A
(en)
|
2012-03-09 |
2018-09-21 |
Pfizer |
Neisseria meningitidis compositions and methods thereof
|
DK2825648T3
(en)
|
2012-03-15 |
2018-10-15 |
Curna Inc |
TREATMENT OF BRAIN-DERIVATIVE NEUROTROPHIC FACTOR (BDNF) -related DISEASES BY INHIBITATION OF NATURAL ANTISENCE TRANSCRIPTION TO BDNF
|
US9441007B2
(en)
|
2012-03-21 |
2016-09-13 |
Alios Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
USRE48171E1
(en)
|
2012-03-21 |
2020-08-25 |
Janssen Biopharma, Inc. |
Substituted nucleosides, nucleotides and analogs thereof
|
WO2013143555A1
(en)
|
2012-03-26 |
2013-10-03 |
Biontech Ag |
Rna formulation for immunotherapy
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
DE18200782T1
(de)
|
2012-04-02 |
2021-10-21 |
Modernatx, Inc. |
Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen
|
US9878056B2
(en)
|
2012-04-02 |
2018-01-30 |
Modernatx, Inc. |
Modified polynucleotides for the production of cosmetic proteins and peptides
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
US9783610B2
(en)
|
2012-04-27 |
2017-10-10 |
The Trustees Of The University Of Pennsylvania |
Anti-tumor endothelial marker-1 (TEM1) antibody variants and uses thereof
|
EP4005576B1
(en)
|
2012-05-21 |
2023-12-13 |
Insmed Incorporated |
Systems for treating pulmonary infections
|
US10240162B2
(en)
|
2012-05-24 |
2019-03-26 |
A.B. Seeds Ltd. |
Compositions and methods for silencing gene expression
|
US9890364B2
(en)
|
2012-05-29 |
2018-02-13 |
The General Hospital Corporation |
TAL-Tet1 fusion proteins and methods of use thereof
|
EP3489220B9
(en)
*
|
2012-06-08 |
2021-11-10 |
Nitto Denko Corporation |
Lipids for therapeutic agent delivery formulations
|
WO2013185067A1
(en)
|
2012-06-08 |
2013-12-12 |
Shire Human Genetic Therapies, Inc. |
Nuclease resistant polynucleotides and uses thereof
|
EP2679596B1
(en)
|
2012-06-27 |
2017-04-12 |
International Aids Vaccine Initiative |
HIV-1 env glycoprotein variant
|
TW201408625A
(zh)
|
2012-07-06 |
2014-03-01 |
Kyowa Hakko Kirin Co Ltd |
陽離子性脂質
|
HUE051612T2
(hu)
|
2012-07-11 |
2021-03-01 |
Sangamo Therapeutics Inc |
Eljárások és készítmények lizoszomális tárolási betegségek kezelésére
|
JP6329537B2
(ja)
|
2012-07-11 |
2018-05-23 |
サンガモ セラピューティクス, インコーポレイテッド |
生物学的薬剤の送達のための方法および組成物
|
CA2878314A1
(en)
|
2012-07-16 |
2014-01-23 |
Kyowa Hakko Kirin Co., Ltd. |
Rnai pharmaceutical composition for suppressing expression of kras gene
|
AU2013296321B2
(en)
|
2012-08-03 |
2019-05-16 |
Alnylam Pharmaceuticals, Inc. |
Modified RNAi agents
|
EP2698377A1
(en)
|
2012-08-17 |
2014-02-19 |
Laboratorios Del. Dr. Esteve, S.A. |
Enhanced rapid immunogen selection method for HIV gp120 variants
|
SG10201701601WA
(en)
|
2012-08-29 |
2017-04-27 |
Sangamo Biosciences Inc |
Methods and compositions for treatment of a genetic condition
|
WO2014035474A1
(en)
|
2012-08-30 |
2014-03-06 |
The General Hospital Corporation |
Compositions and methods for treating cancer
|
US9365856B2
(en)
|
2012-09-14 |
2016-06-14 |
The Board Of Trustees Of The University Of Arkansas |
Methods of using a serum response factor isoform
|
WO2014041179A1
(en)
|
2012-09-17 |
2014-03-20 |
Chemedest Ltd. |
Treatment of peripheral neuropathy using gfr(alpha)3 type receptor agonists
|
WO2014047533A1
(en)
|
2012-09-21 |
2014-03-27 |
Frank Bedu-Addo |
Improved vaccine compositions and methods of use
|
EP2906684B8
(en)
|
2012-10-10 |
2020-09-02 |
Sangamo Therapeutics, Inc. |
T cell modifying compounds and uses thereof
|
EP2906602B1
(en)
|
2012-10-12 |
2019-01-16 |
The General Hospital Corporation |
Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
|
WO2014082729A1
(en)
|
2012-11-28 |
2014-06-05 |
Biontech Ag |
Individualized vaccines for cancer
|
AU2013352259B2
(en)
|
2012-11-29 |
2018-06-14 |
Insmed Incorporated |
Stabilized vancomycin formulations
|
BR112015013105B1
(pt)
|
2012-12-05 |
2022-02-08 |
Alnylam Pharmaceuticals, Inc |
Agente de rnai de fita dupla capaz de inibir a expressão de pcsk9, seus usos, composição farmacêutica e método de inibição da expressão de pcsk9 em uma célula in vitro
|
EP2928303A4
(en)
|
2012-12-07 |
2016-07-13 |
Haplomics Inc |
FACTOR VIII MUTATION REPAIR AND TOLERANCE INDUCTION
|
EP3825401A1
(en)
|
2012-12-12 |
2021-05-26 |
The Broad Institute, Inc. |
Crispr-cas component systems, methods and compositions for sequence manipulation
|
ES2598115T3
(es)
|
2012-12-12 |
2017-01-25 |
The Broad Institute, Inc. |
Ingeniería de sistemas, métodos y composiciones de guía optimizadas para manipulación de secuencias
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
DK2921557T3
(en)
|
2012-12-12 |
2016-11-07 |
Broad Inst Inc |
Design of systems, methods and optimized sequence manipulation guide compositions
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
US8993233B2
(en)
|
2012-12-12 |
2015-03-31 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
AU2013359212B2
(en)
|
2012-12-12 |
2017-01-19 |
Massachusetts Institute Of Technology |
Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
ES2658401T3
(es)
|
2012-12-12 |
2018-03-09 |
The Broad Institute, Inc. |
Suministro, modificación y optimización de sistemas, métodos y composiciones para la manipulación de secuencias y aplicaciones terapéuticas
|
CN105358695B
(zh)
|
2013-01-01 |
2019-07-12 |
A.B.种子有限公司 |
将dsRNA引入植物种子以调节基因表达的方法
|
US10683505B2
(en)
|
2013-01-01 |
2020-06-16 |
Monsanto Technology Llc |
Methods of introducing dsRNA to plant seeds for modulating gene expression
|
WO2014107739A1
(en)
|
2013-01-07 |
2014-07-10 |
Eleven Biotherapeutics, Inc. |
Antibodies against pcsk9
|
WO2014113493A1
(en)
|
2013-01-16 |
2014-07-24 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
CA2900338A1
(en)
|
2013-02-07 |
2014-08-14 |
The General Hospital Corporation |
Tale transcriptional activators
|
JP2016514091A
(ja)
|
2013-02-08 |
2016-05-19 |
ミスフォールディング ダイアグノスティクス, インコーポレイテッド |
トランスサイレチン抗体およびその使用
|
US9371352B2
(en)
|
2013-02-08 |
2016-06-21 |
Vaccinex, Inc. |
Modified glycolipids and methods of making and using the same
|
CA2901978A1
(en)
|
2013-02-20 |
2014-08-28 |
Valerion Therapeutics, Llc |
Methods and compositions for treatment of pompe disease
|
ES2685894T3
(es)
|
2013-03-08 |
2018-10-15 |
Pfizer Inc. |
Polipéptidos de fusión inmunogénicos
|
US10981961B2
(en)
|
2013-03-11 |
2021-04-20 |
University Of Florida Research Foundation, Incorporated |
Delivery of card protein as therapy for occular inflammation
|
ES2853935T3
(es)
|
2013-03-12 |
2021-09-20 |
Massachusetts Gen Hospital |
Proteínas modificadas de sustancia inhibidora muleriana (MIS) y usos de las mismas para el tratamiento de enfermedades
|
US10612019B2
(en)
|
2013-03-13 |
2020-04-07 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
SG10201707855YA
(en)
|
2013-03-13 |
2017-10-30 |
Prothena Biosciences Ltd |
Tau immunotherapy
|
US10609930B2
(en)
|
2013-03-13 |
2020-04-07 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
US9952202B2
(en)
|
2013-03-14 |
2018-04-24 |
Galapagos Nv |
Methods of identifying compounds for the treatment of fibrosis by using S1PR5
|
EA201591707A1
(ru)
|
2013-03-14 |
2016-03-31 |
Элнилэм Фармасьютикалз, Инк. |
КОМПОЗИЦИИ иРНК КОМПОНЕНТА КОМПЛЕМЕНТА C5 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
DK3467108T3
(da)
|
2013-03-14 |
2024-06-10 |
Translate Bio Inc |
Fremgangsmåder til oprensning af messenger-RNA
|
WO2014139883A1
(en)
|
2013-03-14 |
2014-09-18 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases
|
EP2972381A2
(en)
|
2013-03-14 |
2016-01-20 |
Galapagos NV |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
UA117008C2
(uk)
|
2013-03-14 |
2018-06-11 |
Шир Хьюман Дженетік Терапіс, Інк. |
IN VITRO ТРАНСКРИБОВАНА мРНК ТА КОМПОЗИЦІЯ, ЩО ЇЇ МІСТИТЬ, ДЛЯ ЗАСТОСУВАННЯ В ЛІКУВАННІ МУКОВІСЦИДОЗУ В ССАВЦЯ
|
US10568328B2
(en)
|
2013-03-15 |
2020-02-25 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
BR112015022994A2
(pt)
|
2013-03-15 |
2017-11-14 |
Intrexon Corp |
diacilhidrazinas contendo boro
|
US10010504B2
(en)
|
2013-03-15 |
2018-07-03 |
The Penn State Research Foundation |
Compositions and methods including celecoxib and plumbagin relating to treatment of cancer
|
CA2905696A1
(en)
|
2013-03-15 |
2014-09-18 |
The Penn State Research Foundation |
Compositions and methods including leelamine and arachidonyl trifluoromethyl ketone relating to treatment of cancer
|
WO2014145042A1
(en)
|
2013-03-15 |
2014-09-18 |
Loma Linda University |
Treatment of autoimmune diseases
|
US10052364B2
(en)
|
2013-03-15 |
2018-08-21 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for cognitive disorders
|
WO2014180490A1
(en)
|
2013-05-10 |
2014-11-13 |
Biontech Ag |
Predicting immunogenicity of t cell epitopes
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
KR102486617B1
(ko)
|
2013-05-22 |
2023-01-12 |
알닐람 파마슈티칼스 인코포레이티드 |
Tmprss6 조성물 및 이의 사용 방법
|
CA2913234A1
(en)
|
2013-05-22 |
2014-11-27 |
Northwestern University |
Rna-directed dna cleavage and gene editing by cas9 enzyme from neisseria meningitidis
|
PT2999785T
(pt)
|
2013-05-22 |
2018-07-09 |
Alnylam Pharmaceuticals Inc |
Composições de irna de serpina1 e métodos de uso das mesmas
|
WO2014193800A2
(en)
|
2013-05-28 |
2014-12-04 |
The Johns Hopkins University |
Aptamers for the treatment of sickle cell disease
|
AU2014280847B2
(en)
|
2013-06-13 |
2019-07-04 |
Antisense Therapeutics Ltd |
Combination therapy
|
DK3011032T3
(da)
|
2013-06-17 |
2020-01-20 |
Broad Inst Inc |
Fremføring, modificering og optimering af systemer, fremgangsmåder og sammensætninger til målretning mod og modellering af sygdomme og forstyrrelser i postmitotiske celler
|
CN106062197A
(zh)
|
2013-06-17 |
2016-10-26 |
布罗德研究所有限公司 |
用于序列操纵的串联指导系统、方法和组合物的递送、工程化和优化
|
RU2716420C2
(ru)
|
2013-06-17 |
2020-03-11 |
Те Брод Инститьют Инк. |
Доставка и применение систем crispr-cas, векторов и композиций для целенаправленного воздействия и терапии в печени
|
WO2014204729A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components
|
AU2014281027A1
(en)
|
2013-06-17 |
2016-01-28 |
Massachusetts Institute Of Technology |
Optimized CRISPR-Cas double nickase systems, methods and compositions for sequence manipulation
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
EP3013945B1
(en)
|
2013-06-25 |
2020-05-27 |
Temple University Of The Commonwealth System Of Higher Education |
Cortical bone-derived stem cells
|
US9856472B2
(en)
|
2013-07-01 |
2018-01-02 |
California Institute Of Technology |
Small conditional RNAs
|
US9850496B2
(en)
|
2013-07-19 |
2017-12-26 |
Monsanto Technology Llc |
Compositions and methods for controlling Leptinotarsa
|
BR112016000555B1
(pt)
|
2013-07-19 |
2022-12-27 |
Monsanto Technology Llc |
Método para controlar uma infestação da espécie de leptinotarsa em uma planta, composição inseticida e construção de dna recombinante
|
EP3677567A1
(en)
|
2013-07-23 |
2020-07-08 |
Arbutus Biopharma Corporation |
Compositions and methods for delivering messenger rna
|
CA2919268C
(en)
|
2013-07-25 |
2023-09-05 |
Exicure, Inc. |
Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
US10568898B2
(en)
*
|
2013-08-13 |
2020-02-25 |
Northwestern University |
Lipophilic nanoparticles for drug delivery
|
EP3039136B8
(en)
|
2013-08-28 |
2020-12-16 |
Sangamo Therapeutics, Inc. |
Compositions for linking dna-binding domains and cleavage domains
|
WO2015031645A1
(en)
|
2013-08-28 |
2015-03-05 |
Washington University |
Monoclonal antibodies to human 14-3-3 epsilon and human 14-3-3 epsilon sv
|
US20150197534A1
(en)
|
2013-09-05 |
2015-07-16 |
Sarepta Therapeutics, Inc. |
Antisense-induced exon2 inclusion in acid alpha-glucosidase
|
EP2848937A1
(en)
|
2013-09-05 |
2015-03-18 |
International Aids Vaccine Initiative |
Methods of identifying novel HIV-1 immunogens
|
US9340800B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
Extended DNA-sensing GRNAS
|
WO2015033251A2
(en)
|
2013-09-08 |
2015-03-12 |
Pfizer Inc. |
Neisseria meningitidis compositions and methods thereof
|
US10036020B2
(en)
|
2013-09-19 |
2018-07-31 |
The United States Of America, As Represented By The Secretary, Department Of Health & Human Services |
Compositions and methods for inhibiting JC virus (JCV)
|
WO2015042564A1
(en)
|
2013-09-23 |
2015-03-26 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing transthyretin (ttr) associated diseases
|
WO2015048115A1
(en)
|
2013-09-25 |
2015-04-02 |
Zoetis Llc |
Pcv2b divergent vaccine composition and methods of use
|
US10058604B2
(en)
|
2013-10-07 |
2018-08-28 |
International Aids Vaccine Initiative |
Soluble HIV-1 envelope glycoprotein trimers
|
CA3194037A1
(en)
|
2013-10-17 |
2015-04-23 |
Sangamo Biosciences, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
EP3060303B1
(en)
|
2013-10-22 |
2018-11-14 |
Translate Bio, Inc. |
Mrna therapy for argininosuccinate synthetase deficiency
|
EA201992208A1
(ru)
|
2013-10-22 |
2020-07-31 |
Транслейт Био, Инк. |
ЛЕЧЕНИЕ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК
|
RU2694950C2
(ru)
|
2013-11-04 |
2019-07-18 |
Монсанто Текнолоджи Ллс |
Композиции и способы для борьбы с членистоногими паразитами и заражениями вредителями
|
US9469650B2
(en)
|
2013-11-08 |
2016-10-18 |
Board Of Trustees Of The University Of Arkansas |
Melampomagnolide B derivatives
|
US9487536B2
(en)
|
2013-11-08 |
2016-11-08 |
Board Of Trustees Of The University Of Arkansas |
Melampomagnolide B derivatives
|
JP2016537341A
(ja)
|
2013-11-11 |
2016-12-01 |
サンガモ バイオサイエンシーズ, インコーポレイテッド |
ハンチントン病を処置するための方法および組成物
|
PL3068881T3
(pl)
|
2013-11-13 |
2019-08-30 |
Children's Medical Center Corporation |
Regulacja ekspresji genów, w której pośredniczą nukleazy
|
CN112107693B
(zh)
|
2013-12-03 |
2023-05-26 |
西北大学 |
脂质体颗粒、制备所述脂质体颗粒的方法以及其用途
|
CA2932753A1
(en)
|
2013-12-04 |
2015-06-11 |
Rxi Pharmaceuticals Corporation |
Methods for treatment of wound healing utilizing chemically modified oligonucleotides
|
CA3229275A1
(en)
|
2013-12-09 |
2015-06-18 |
Sangamo Biosciences, Inc. |
Methods and compositions for genome engineering
|
UA119253C2
(uk)
|
2013-12-10 |
2019-05-27 |
Біолоджикс, Інк. |
Спосіб боротьби із вірусом у кліща varroa та у бджіл
|
WO2015089321A2
(en)
|
2013-12-11 |
2015-06-18 |
The General Hospital Corporation |
Use of mullerian inhibiting substance (mis) proteins for contraception and ovarian reserve preservation
|
AU2014361784A1
(en)
|
2013-12-12 |
2016-06-23 |
Massachusetts Institute Of Technology |
Delivery, use and therapeutic applications of the CRISPR-Cas systems and compositions for HBV and viral diseases and disorders
|
EP3080271B1
(en)
|
2013-12-12 |
2020-02-12 |
The Broad Institute, Inc. |
Systems, methods and compositions for sequence manipulation with optimized functional crispr-cas systems
|
EP3079726B1
(en)
|
2013-12-12 |
2018-12-05 |
The Broad Institute, Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using particle delivery components
|
JP7103750B2
(ja)
|
2013-12-12 |
2022-07-20 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
ゲノム編集のためのCRISPR-Cas系及び組成物の送達、使用及び治療適用
|
WO2015089368A2
(en)
|
2013-12-12 |
2015-06-18 |
Alnylam Pharmaceuticals, Inc. |
Complement component irna compositions and methods of use thereof
|
US10119136B2
(en)
|
2014-01-09 |
2018-11-06 |
Alnylam Pharmaceuticals, Inc. |
RNAi agents modified at the 4′-C position
|
BR112016016337A2
(pt)
|
2014-01-15 |
2017-10-03 |
Monsanto Technology Llc |
Composição e métodos para controlar crescimento, desenvolvimento ou a capacidade de reprodução de uma planta, e para sensibilizar uma planta para um herbicida inibidor de epsps
|
WO2015116902A1
(en)
|
2014-01-31 |
2015-08-06 |
Genentech, Inc. |
G-protein coupled receptors in hedgehog signaling
|
DK3102673T3
(da)
|
2014-02-03 |
2020-07-06 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandling af beta-talassæmi
|
ES2694857T3
(es)
|
2014-02-04 |
2018-12-27 |
Genentech, Inc. |
Smoothened mutante y métodos de uso de la misma
|
JP6594902B2
(ja)
|
2014-02-11 |
2019-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ケトヘキソキナーゼ(KHK)iRNA組成物及びその使用方法
|
US11053291B2
(en)
|
2014-02-19 |
2021-07-06 |
University Of Florida Research Foundation, Incorporated |
Delivery of Nrf2 as therapy for protection against reactive oxygen species
|
WO2015130584A2
(en)
|
2014-02-25 |
2015-09-03 |
Merck Sharp & Dohme Corp. |
Lipid nanoparticle vaccine adjuvants and antigen delivery systems
|
KR101605421B1
(ko)
|
2014-03-05 |
2016-03-23 |
국립암센터 |
B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
|
EP3929279A1
(en)
|
2014-03-18 |
2021-12-29 |
Sangamo Therapeutics, Inc. |
Methods and compositions for regulation of zinc finger protein expression
|
US11091770B2
(en)
|
2014-04-01 |
2021-08-17 |
Monsanto Technology Llc |
Compositions and methods for controlling insect pests
|
JP6571679B2
(ja)
|
2014-04-25 |
2019-09-04 |
トランスレイト バイオ, インコーポレイテッド |
メッセンジャーrnaの精製方法
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
WO2015168605A1
(en)
|
2014-05-01 |
2015-11-05 |
Rxi Pharmaceuticals Corporation |
Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules
|
CN106456699B
(zh)
|
2014-05-05 |
2021-07-02 |
生物风险投资有限责任公司 |
作为抗老化剂抑制抗凋亡的Bcl-2蛋白的组合物和方法
|
WO2015171918A2
(en)
|
2014-05-07 |
2015-11-12 |
Louisiana State University And Agricultural And Mechanical College |
Compositions and uses for treatment thereof
|
AU2015255877B2
(en)
|
2014-05-08 |
2020-03-26 |
Chdi Foundation, Inc. |
Methods and compositions for treating huntington's disease
|
US9895385B2
(en)
|
2014-05-15 |
2018-02-20 |
Insmed Incorporated |
Methods for treating pulmonary non-tuberculous mycobacterial infections
|
AU2015264038B2
(en)
|
2014-05-22 |
2021-02-11 |
Alnylam Pharmaceuticals, Inc. |
Angiotensinogen (AGT) iRNA compositions and methods of use thereof
|
AU2015266776A1
(en)
|
2014-05-30 |
2016-12-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods of delivering treatments for latent viral infections
|
EP3508198A1
(en)
|
2014-06-04 |
2019-07-10 |
Exicure, Inc. |
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
|
JP6930834B2
(ja)
|
2014-06-16 |
2021-09-01 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
H1プロモーターを用いるcrisprガイドrnaの発現のための組成物および方法
|
CN106795515B
(zh)
|
2014-06-23 |
2021-06-08 |
孟山都技术公司 |
用于经由rna干扰调控基因表达的组合物和方法
|
EP3161138A4
(en)
|
2014-06-25 |
2017-12-06 |
Monsanto Technology LLC |
Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
|
CA2985344A1
(en)
|
2014-06-26 |
2015-12-30 |
The Trustees Of Columbia University In The City Of New York |
Inhibition of serotonin expression in gut enteroendocrine cells results in conversion to insulin-positive cells
|
WO2016011203A1
(en)
|
2014-07-15 |
2016-01-21 |
Life Technologies Corporation |
Compositions with lipid aggregates and methods for efficient delivery of molecules to cells
|
KR20170032406A
(ko)
|
2014-07-15 |
2017-03-22 |
주노 쎄러퓨티크스 인코퍼레이티드 |
입양 세포 치료를 위한 조작된 세포
|
AU2015292710A1
(en)
|
2014-07-22 |
2017-02-16 |
Bioventures, Llc. |
Compositions and methods for selectively depleting senescent cells
|
WO2016014939A1
(en)
|
2014-07-24 |
2016-01-28 |
Washington University |
Compositions targeting radiation-induced molecules and methods of use thereof
|
KR102330593B1
(ko)
|
2014-07-28 |
2021-11-26 |
에스케이이노베이션 주식회사 |
신규 이소프렌 신타아제 및 이를 이용한 이소프렌의 제조방법
|
US10378012B2
(en)
|
2014-07-29 |
2019-08-13 |
Monsanto Technology Llc |
Compositions and methods for controlling insect pests
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
ES2780904T3
(es)
|
2014-08-17 |
2020-08-27 |
Broad Inst Inc |
Edición genómica usando nickasas Cas9
|
EP3812462A1
(en)
|
2014-08-20 |
2021-04-28 |
Alnylam Pharmaceuticals, Inc. |
Modified double-stranded rna agents
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
US10900039B2
(en)
|
2014-09-05 |
2021-01-26 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
|
UA121222C2
(uk)
|
2014-09-10 |
2020-04-27 |
Вашингтон Юніверсіті |
Композиції та способи для лікування передракових уражень шкіри
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
PT3194570T
(pt)
|
2014-09-16 |
2021-08-06 |
Sangamo Therapeutics Inc |
Métodos e composições para manipulação e correção de genoma mediada por nuclease em células estaminais hematopoiéticas
|
AU2015317862A1
(en)
|
2014-09-17 |
2017-04-06 |
Intrexon Corporation |
Boron-containing diacylhydrazine compounds
|
WO2016049163A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Use and production of chd8+/- transgenic animals with behavioral phenotypes characteristic of autism spectrum disorder
|
WO2016049251A1
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling mutations in leukocytes
|
WO2016049024A2
(en)
|
2014-09-24 |
2016-03-31 |
The Broad Institute Inc. |
Delivery, use and therapeutic applications of the crispr-cas systems and compositions for modeling competition of multiple cancer mutations in vivo
|
WO2016045732A1
(en)
|
2014-09-25 |
2016-03-31 |
Biontech Rna Pharmaceuticals Gmbh |
Stable formulations of lipids and liposomes
|
SG11201702662UA
(en)
|
2014-10-02 |
2017-04-27 |
Protiva Biotherapeutics Inc |
Compositions and methods for silencing hepatitis b virus gene expression
|
WO2016057549A1
(en)
|
2014-10-06 |
2016-04-14 |
Aurasense Therapeutics, Llc |
Anti-tnf compounds
|
US20170304459A1
(en)
|
2014-10-10 |
2017-10-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhalation delivery of conjugated oligonucleotide
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
WO2016064832A1
(en)
|
2014-10-20 |
2016-04-28 |
The Curators Of The University Of Missouri |
Method for treating lymphedema
|
WO2016069694A2
(en)
|
2014-10-30 |
2016-05-06 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
JP2017535552A
(ja)
|
2014-11-17 |
2017-11-30 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
アポリポタンパク質C3(APOC3)iRNA組成物およびその使用方法
|
WO2016081728A1
(en)
|
2014-11-19 |
2016-05-26 |
The Trustees Of Columbia University In The City Of New York |
Osteocalcin as a treatment for frailty associated with aging
|
WO2016085986A1
(en)
|
2014-11-24 |
2016-06-02 |
Northwestern University |
High density lipoprptein nanoparticles for inflammation
|
US9981990B2
(en)
|
2014-12-03 |
2018-05-29 |
Bioventures, Llc |
Melampomagnolide B dimers
|
JP6583682B2
(ja)
*
|
2014-12-08 |
2019-10-02 |
日油株式会社 |
カチオン性脂質の製造方法
|
WO2016094874A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Escorted and functionalized guides for crispr-cas systems
|
EP3230452A1
(en)
|
2014-12-12 |
2017-10-18 |
The Broad Institute Inc. |
Dead guides for crispr transcription factors
|
WO2016094867A1
(en)
|
2014-12-12 |
2016-06-16 |
The Broad Institute Inc. |
Protected guide rnas (pgrnas)
|
EP3233192B1
(en)
|
2014-12-15 |
2021-04-14 |
Washington University |
Compositions and methods for targeted cytokine delivery
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
AU2015369725A1
(en)
|
2014-12-24 |
2017-06-29 |
Massachusetts Institute Of Technology |
CRISPR having or associated with destabilization domains
|
WO2016108926A1
(en)
|
2014-12-30 |
2016-07-07 |
The Broad Institute Inc. |
Crispr mediated in vivo modeling and genetic screening of tumor growth and metastasis
|
CN108064288B
(zh)
|
2015-01-22 |
2021-11-26 |
孟山都技术公司 |
用于控制叶甲属的组合物和方法
|
KR20190112855A
(ko)
|
2015-01-28 |
2019-10-07 |
파이어니어 하이 부렛드 인터내쇼날 인코포레이팃드 |
Crispr 하이브리드 dna/rna 폴리뉴클레오티드 및 사용 방법
|
WO2016128060A1
(en)
|
2015-02-12 |
2016-08-18 |
Biontech Ag |
Predicting t cell epitopes useful for vaccination
|
AU2016219263B2
(en)
|
2015-02-13 |
2022-12-01 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (PNPLA3) iRNA compositions and methods of use thereof
|
KR20190049940A
(ko)
|
2015-02-19 |
2019-05-09 |
화이자 인코포레이티드 |
나이세리아 메닌지티디스 조성물 및 그의 방법
|
CN107530291A
(zh)
*
|
2015-03-03 |
2018-01-02 |
奎尔波特股份有限公司 |
双重负载的脂质体药物制剂
|
CN107530283A
(zh)
|
2015-03-03 |
2018-01-02 |
奎尔波特股份有限公司 |
组合脂质体药物制剂
|
MA41795A
(fr)
|
2015-03-18 |
2018-01-23 |
Sarepta Therapeutics Inc |
Exclusion d'un exon induite par des composés antisens dans la myostatine
|
US10174292B2
(en)
|
2015-03-20 |
2019-01-08 |
International Aids Vaccine Initiative |
Soluble HIV-1 envelope glycoprotein trimers
|
US9931394B2
(en)
|
2015-03-23 |
2018-04-03 |
International Aids Vaccine Initiative |
Soluble HIV-1 envelope glycoprotein trimers
|
EP3277823B1
(en)
|
2015-04-03 |
2023-09-13 |
Dana-Farber Cancer Institute, Inc. |
Composition and methods of genome editing of b-cells
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
WO2016168601A1
(en)
|
2015-04-17 |
2016-10-20 |
Khalid Shah |
Agents, systems and methods for treating cancer
|
HRP20220138T1
(hr)
|
2015-05-01 |
2022-05-27 |
Onl Therapeutics, Inc. |
Peptidni pripravci i postupci uporabe
|
BR112017021967A2
(pt)
|
2015-05-06 |
2018-07-31 |
Alnylam Pharmaceuticals Inc |
composições do fator xii (fator hageman) (f12), kallikrein b, plasma (fator fletcher) 1 (klkb1), e kininogen 1 (kng1) irna e métodos de uso dos mesmos
|
EP3298134B8
(en)
|
2015-05-16 |
2023-06-21 |
Genzyme Corporation |
Gene editing of deep intronic mutations
|
US10716827B2
(en)
|
2015-05-20 |
2020-07-21 |
Syracuse University |
Compositions and methods for enhancing peptide stability against protease digestion
|
US20180154007A1
(en)
|
2015-05-20 |
2018-06-07 |
Syracuse University |
Glycemic Control Using Intrinsic Factor Bound to A Vitamin B12 Conjugate of a Glucagon-Like Peptide-1 Receptor Agonist
|
JP6949728B2
(ja)
|
2015-05-29 |
2021-10-13 |
ジュノー セラピューティクス インコーポレイテッド |
遺伝子操作された細胞における阻害相互作用を調節するための組成物および方法
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
JP6873052B2
(ja)
|
2015-06-01 |
2021-05-19 |
サレプタ セラピューティクス,インコーポレイテッド |
Vii型コラーゲンにおけるアンチセンス誘導エクソン排除
|
EP3302053B1
(en)
|
2015-06-02 |
2021-03-17 |
Monsanto Technology LLC |
Compositions and methods for delivery of a polynucleotide into a plant
|
WO2016196782A1
(en)
|
2015-06-03 |
2016-12-08 |
Monsanto Technology Llc |
Methods and compositions for introducing nucleic acids into plants
|
WO2016197132A1
(en)
|
2015-06-04 |
2016-12-08 |
Protiva Biotherapeutics Inc. |
Treating hepatitis b virus infection using crispr
|
WO2016201301A1
(en)
|
2015-06-12 |
2016-12-15 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
TW201710503A
(zh)
|
2015-06-12 |
2017-03-16 |
長庚醫療財團法人林口長庚紀念醫院 |
新穎多核苷酸、載體、醫藥組成物以及其用途
|
WO2016205728A1
(en)
|
2015-06-17 |
2016-12-22 |
Massachusetts Institute Of Technology |
Crispr mediated recording of cellular events
|
WO2016205749A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
FI3430134T3
(fi)
|
2015-06-18 |
2023-01-13 |
|
Uusia CRISPR-entsyymejä ja järjestelmiä
|
WO2016205323A1
(en)
|
2015-06-18 |
2016-12-22 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotde agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
EP3862005A1
(en)
|
2015-07-06 |
2021-08-11 |
Phio Pharmaceuticals Corp. |
Nucleic acid molecules targeting superoxide dismutase 1 (sod1)
|
WO2017011286A1
(en)
|
2015-07-10 |
2017-01-19 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof
|
CA2991301A1
(en)
|
2015-07-13 |
2017-01-19 |
Sangamo Therapeutics, Inc. |
Delivery methods and compositions for nuclease-mediated genome engineering
|
CN108136008A
(zh)
|
2015-07-15 |
2018-06-08 |
华盛顿大学 |
针对具有末端GlcNAcβ残基的肿瘤相关复合N-聚糖的抗体及其使用方法
|
MA42895A
(fr)
|
2015-07-15 |
2018-05-23 |
Juno Therapeutics Inc |
Cellules modifiées pour thérapie cellulaire adoptive
|
WO2017019891A2
(en)
|
2015-07-29 |
2017-02-02 |
Protiva Biotherapeutics, Inc. |
Compositions and methods for silencing hepatitis b virus gene expression
|
WO2017024317A2
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Methods to induce targeted protein degradation through bifunctional molecules
|
CA2995995A1
(en)
|
2015-08-24 |
2017-03-02 |
Halo-Bio Rnai Therapeutics, Inc. |
Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
|
WO2017040287A1
(en)
|
2015-08-28 |
2017-03-09 |
Serpin Pharma, Llc |
Methods for treatment of diseases
|
KR20180051550A
(ko)
|
2015-09-02 |
2018-05-16 |
알닐람 파마슈티칼스 인코포레이티드 |
프로그램된 세포사 1 리간드 1 (PD-L1) iRNA 조성물 및 그의 사용 방법
|
EP3350328A1
(en)
|
2015-09-14 |
2018-07-25 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
|
AU2016328279A1
(en)
|
2015-09-24 |
2018-05-10 |
The University Of North Carolina At Chapel Hill |
Methods and compositions for reducing metastases
|
US10954300B2
(en)
|
2015-09-28 |
2021-03-23 |
The Trustees Of Columbia University In The City Of New York |
Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
|
WO2017059902A1
(en)
|
2015-10-07 |
2017-04-13 |
Biontech Rna Pharmaceuticals Gmbh |
3' utr sequences for stabilization of rna
|
EP3858993A1
(en)
|
2015-10-09 |
2021-08-04 |
Sarepta Therapeutics, Inc. |
Compositions and methods for treating duchenne muscular dystrophy and related disorders
|
CA3000917A1
(en)
|
2015-10-09 |
2017-04-13 |
Monsanto Technology Llc |
Rna-guided nucleases and uses thereof
|
US20190062394A1
(en)
|
2015-10-10 |
2019-02-28 |
Intrexon Corporation |
Improved Therapeutic Control of Proteolytically Sensitive, Destabilized Forms of Interleukin-12
|
BR122021024957B1
(pt)
|
2015-10-16 |
2023-12-12 |
Ipsen Biopharm Ltd |
Processos de produção de uma composição de irinotecano lipossômico estabilizado em armazenamento
|
EP3365446A4
(en)
|
2015-10-19 |
2019-06-26 |
Phio Pharmaceuticals Corp. |
SELF ADMINISTRATION-REDUCED SIZE NUCLEIC ACID COMPOUNDS TARGETING LONGS NON-CODING LONGS
|
WO2017070605A1
(en)
|
2015-10-22 |
2017-04-27 |
The Broad Institute Inc. |
Type vi-b crispr enzymes and systems
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
WO2017075670A1
(en)
|
2015-11-05 |
2017-05-11 |
Children's Hospital Los Angeles |
"mobilizing leukemia cells"
|
US20180319815A1
(en)
|
2015-11-05 |
2018-11-08 |
Board Of Trustees Of The University Of Arkansas |
Hetero-substituted cyclic lactone analogues and uses thereof
|
WO2017083820A1
(en)
|
2015-11-13 |
2017-05-18 |
Pds Biotechnology Corporation |
Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy
|
EP3386593A4
(en)
|
2015-12-09 |
2019-07-24 |
Admedus Vaccines Pty Ltd |
IMMUNOMODULATING COMPOSITION FOR TREATMENT
|
JP2018536689A
(ja)
|
2015-12-10 |
2018-12-13 |
アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. |
ステロール調節エレメント結合タンパク質(SREBP)シャペロン(SCAP)iRNA組成物およびその使用方法
|
AU2016374253B2
(en)
|
2015-12-18 |
2021-10-21 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the MHC cell receptor
|
US11352631B2
(en)
|
2015-12-18 |
2022-06-07 |
Sangamo Therapeutics, Inc. |
Targeted disruption of the T cell receptor
|
US20190233814A1
(en)
|
2015-12-18 |
2019-08-01 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
WO2017106926A1
(en)
|
2015-12-23 |
2017-06-29 |
Queensland University Of Technology |
Nucleic acid oligomers and uses therefor
|
TW201726614A
(zh)
|
2015-12-25 |
2017-08-01 |
Kyowa Hakko Kirin Co Ltd |
作為陽離子性脂質之化合物
|
WO2017120589A1
(en)
|
2016-01-08 |
2017-07-13 |
Washington University |
Compositions comprising chemerin and methods of use thereof
|
JP6930052B2
(ja)
|
2016-01-15 |
2021-09-01 |
サンガモ セラピューティクス, インコーポレイテッド |
神経性疾患の処置のための方法および組成物
|
EP3407885A4
(en)
|
2016-01-29 |
2019-06-19 |
BioVentures, LLC |
TRIAZOLE DERIVATIVES OF MELAMPOMAGNOLIDE B AND METHODS OF USE THEREOF
|
AU2016391970B2
(en)
|
2016-02-02 |
2024-02-22 |
Sangamo Therapeutics, Inc. |
Compositions for linking DNA-binding domains and cleavage domains
|
CA3019952A1
(en)
|
2016-02-04 |
2017-08-10 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
AU2017213659B2
(en)
|
2016-02-05 |
2024-04-18 |
Washington University |
Compositions and methods for targeted cytokine delivery
|
DK3653709T3
(da)
|
2016-02-22 |
2021-03-08 |
Caribou Biosciences Inc |
Fremgangsmåder til modulering af dna-reparationsresultater
|
GB201604235D0
(en)
|
2016-03-11 |
2016-04-27 |
Ucl Business Plc |
Lipids and complexes for the delivery of biologically-active material to cells
|
EP3433263A4
(en)
|
2016-03-24 |
2019-10-23 |
Marquette University |
QUANTITATIVE FLAGELLAR FLUORESCENT MARKERS AND STANDARDS
|
US10213448B2
(en)
|
2016-03-25 |
2019-02-26 |
Novazoi Theranostics |
Ethanolamine-based lipid biosynthetic compounds, method of making and use thereof
|
US11060089B2
(en)
|
2016-04-18 |
2021-07-13 |
Sarepta Therapeutics, Inc. |
Antisense oligomers and methods of using the same for treating diseases associated with the acid alpha-glucosidase gene
|
EP3445856A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
EP3445853A1
(en)
|
2016-04-19 |
2019-02-27 |
The Broad Institute, Inc. |
Cpf1 complexes with reduced indel activity
|
WO2017184768A1
(en)
|
2016-04-19 |
2017-10-26 |
The Broad Institute Inc. |
Novel crispr enzymes and systems
|
CA3018991A1
(en)
|
2016-04-21 |
2017-10-26 |
Bioventures, Llc |
Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof
|
CA3022673A1
(en)
|
2016-05-02 |
2017-11-09 |
Prothena Biosciences Limited |
Tau immunotherapy
|
BR112018072394A2
(pt)
|
2016-05-02 |
2019-02-19 |
Prothena Biosciences Limited |
anticorpos que reconhecem a tau
|
EP3452508A1
(en)
|
2016-05-02 |
2019-03-13 |
Prothena Biosciences Limited |
Antibodies recognizing tau
|
WO2017193087A1
(en)
|
2016-05-06 |
2017-11-09 |
Exicure, Inc. |
Liposomal spherical nucleic acid (sna) constructs prsenting antisense oligonucleotides(aso) for specific knockdown of interleukin 17 receptor mrna
|
EP3469083A1
(en)
|
2016-06-10 |
2019-04-17 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
JP2020511931A
(ja)
|
2016-06-16 |
2020-04-23 |
オスロ ウニヴェルスィテーツスィーケフース ハーエフOslo Universitetssykehus Hf |
改良された遺伝子編集
|
US11788083B2
(en)
|
2016-06-17 |
2023-10-17 |
The Broad Institute, Inc. |
Type VI CRISPR orthologs and systems
|
US20210222164A1
(en)
|
2016-06-29 |
2021-07-22 |
The Broad Institute, Inc. |
Crispr-cas systems having destabilization domain
|
CN109563511A
(zh)
|
2016-06-30 |
2019-04-02 |
阿布特斯生物制药公司 |
用于递送信使rna的组合物和方法
|
IL302802A
(en)
|
2016-07-05 |
2023-07-01 |
California Inst Of Techn |
Hybridization chain reaction based on a minimal initiator
|
CN109844116A
(zh)
|
2016-07-05 |
2019-06-04 |
约翰霍普金斯大学 |
包括使用h1启动子对crispr指导rna的改进的组合物和方法
|
AU2017295720B2
(en)
|
2016-07-13 |
2021-07-22 |
Vertex Pharmaceuticals Incorporated |
Methods, compositions and kits for increasing genome editing efficiency
|
EP3485023B1
(en)
|
2016-07-15 |
2023-11-15 |
Salk Institute for Biological Studies |
Methods and compositions for genome editing in non-dividing cells
|
CA2937157A1
(en)
|
2016-07-25 |
2018-01-25 |
Ucl Business Plc |
Protein-based t-cell receptor knockdown
|
CA3032699A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harvard College |
Adenosine nucleobase editors and uses thereof
|
JP2019528312A
(ja)
|
2016-08-07 |
2019-10-10 |
ノバルティス アーゲー |
mRNA媒介性の免疫化方法
|
WO2018031683A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
CN110114461A
(zh)
|
2016-08-17 |
2019-08-09 |
博德研究所 |
新型crispr酶和系统
|
US20200283743A1
(en)
|
2016-08-17 |
2020-09-10 |
The Broad Institute, Inc. |
Novel crispr enzymes and systems
|
JP7203014B2
(ja)
|
2016-08-24 |
2023-01-12 |
サンガモ セラピューティクス, インコーポレイテッド |
工学操作されたヌクレアーゼを使用した遺伝子発現の調節
|
EP3504327B1
(en)
|
2016-08-24 |
2021-10-06 |
Sangamo Therapeutics, Inc. |
Engineered target specific nucleases
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
IL264831B
(en)
|
2016-08-30 |
2022-09-01 |
California Inst Of Techn |
Immunohistochemistry by hybridization chain reaction
|
US20210284998A1
(en)
*
|
2016-10-03 |
2021-09-16 |
Precision Nanosystems Inc. |
Compositions for Transfecting Resistant Cell Types
|
EP3523422A1
(en)
|
2016-10-05 |
2019-08-14 |
FUJIFILM Cellular Dynamics, Inc. |
Generating mature lineages from induced pluripotent stem cells with mecp2 disruption
|
CA3037387A1
(en)
|
2016-10-13 |
2018-04-19 |
Juno Therapeutics, Inc. |
Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators
|
EP3526320A1
(en)
|
2016-10-14 |
2019-08-21 |
President and Fellows of Harvard College |
Aav delivery of nucleobase editors
|
JP7042263B2
(ja)
|
2016-10-20 |
2022-03-25 |
サンガモ セラピューティクス, インコーポレイテッド |
ファブリー病の治療のための方法および組成物
|
US20190314486A1
(en)
|
2016-10-21 |
2019-10-17 |
Merck Sharp & Dohme Corp. |
Influenza hemagglutinin protein vaccines
|
WO2018081388A1
(en)
|
2016-10-26 |
2018-05-03 |
Washington University |
Compositions comprising desaminotyrosine and uses thereof to enhance type i interferon stimulation
|
EP3532106A4
(en)
|
2016-10-31 |
2020-06-24 |
Sangamo Therapeutics, Inc. |
GENE CORRECTION OF SCID-RELATED GENES IN HEMATOPOIETIC AND PROGENITANT STEM CELLS
|
EP3538660A1
(en)
|
2016-11-09 |
2019-09-18 |
Intrexon Corporation |
Frataxin expression constructs
|
US10011848B2
(en)
|
2016-11-09 |
2018-07-03 |
City University Of Hong Kong |
System and method for delivery of substance into mammalian cells
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法
|
CA3045323A1
(en)
|
2016-12-02 |
2018-06-07 |
Juno Therapeutics, Inc. |
Engineered b cells and related compositions and methods
|
MA49610A
(fr)
|
2016-12-08 |
2020-05-27 |
Univ Case Western Reserve |
Procédés et compositions pour améliorer la production de myéline fonctionnelle
|
KR20230166146A
(ko)
|
2016-12-16 |
2023-12-06 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물을 사용하여 TTR-관련 질병을 치료하거나 예방하는 방법
|
ES2962711T3
(es)
|
2016-12-20 |
2024-03-20 |
Bristol Myers Squibb Co |
Métodos para aumentar la eficacia de la reparación dirigida por homología (HDR) en el genoma celular
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
AU2018215585B2
(en)
|
2017-01-31 |
2022-03-17 |
Pfizer Inc. |
Neisseria meningitidis compositions and methods thereof
|
US11352436B2
(en)
|
2017-02-10 |
2022-06-07 |
Washington University |
Antibodies to TIP1 and methods of use thereof
|
CA3054062A1
(en)
|
2017-02-27 |
2018-08-30 |
Translate Bio, Inc. |
Novel codon-optimized cftr mrna
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
US11795192B2
(en)
|
2017-03-10 |
2023-10-24 |
Lakewood Amedex, Inc. |
Antimicrobial compounds, compositions, and uses thereof
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
KR102185464B1
(ko)
|
2017-03-15 |
2020-12-03 |
매사추세츠 인스티튜트 오브 테크놀로지 |
신규 cas13b 오르소로그 crispr 효소 및 시스템
|
KR102687373B1
(ko)
|
2017-03-23 |
2024-07-23 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
EP3985113A1
(en)
|
2017-03-28 |
2022-04-20 |
Locanabio, Inc. |
Crispr-associated (cas) protein
|
CA3059757A1
(en)
|
2017-04-12 |
2018-10-18 |
The Broad Institute, Inc. |
Novel type vi crispr orthologs and systems
|
SG11201909572QA
(en)
|
2017-04-18 |
2019-11-28 |
Alnylam Pharmaceuticals Inc |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
WO2018201091A1
(en)
|
2017-04-27 |
2018-11-01 |
Washington University |
Chemokine decoy receptors of rodent gammaherpesviruses and uses thereof
|
WO2018201088A1
(en)
|
2017-04-27 |
2018-11-01 |
Washington University |
Activation of natural cytotoxicity receptor 2 (ncr2)
|
FI3615674T3
(fi)
|
2017-04-28 |
2024-06-18 |
Univ Colorado Regents |
Menetelmiä reumatoidin artriitin hoitoon HLA-geenin RNA-ohjattua genomin muokkausta käyttämällä
|
US11696954B2
(en)
|
2017-04-28 |
2023-07-11 |
Exicure Operating Company |
Synthesis of spherical nucleic acids using lipophilic moieties
|
IL270375B1
(en)
|
2017-05-02 |
2024-08-01 |
Prothena Biosciences Ltd |
Antibodies that recognize tau
|
CN110621688A
(zh)
|
2017-05-09 |
2019-12-27 |
非营利性组织佛兰芒综合大学生物技术研究所 |
用于治疗细菌感染的手段和方法
|
WO2018208910A1
(en)
|
2017-05-09 |
2018-11-15 |
The Broad Institute Inc. |
Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases
|
US11013905B2
(en)
|
2017-05-11 |
2021-05-25 |
Tci Llc |
Thermal interconnect for implantable blood pump
|
WO2018209288A1
(en)
|
2017-05-12 |
2018-11-15 |
Massachusetts Institute Of Technology |
Argonaute protein-double stranded rna complexes and uses related thereto
|
WO2018209320A1
(en)
|
2017-05-12 |
2018-11-15 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation
|
EP3624824B1
(en)
|
2017-05-16 |
2024-07-10 |
Translate Bio, Inc. |
Codon-optimized mrna encoding cftr for use in treating cystic fibrosis
|
EP3638304B1
(en)
|
2017-06-12 |
2024-07-31 |
Washington University |
Engineered oncolytic zika virus for use in the treatment of cancer
|
LT3538645T
(lt)
|
2017-06-20 |
2021-04-26 |
Institut Curie |
Suv39h1 atžvilgiu defektyvios imuninės ląstelės
|
MX2019015047A
(es)
|
2017-06-23 |
2020-08-03 |
Inscripta Inc |
Nucleasas guiadas por acidos nucleicos.
|
EP3645054A4
(en)
|
2017-06-26 |
2021-03-31 |
The Broad Institute, Inc. |
COMPOSITIONS BASED ON CRISPR / CAS-ADENIN-DEAMINASE, SYSTEMS AND METHODS FOR TARGETED NUCLEIC ACID EDITING
|
KR20200028997A
(ko)
|
2017-07-13 |
2020-03-17 |
노오쓰웨스턴 유니버시티 |
올리고뉴클레오타이드-작용화된 금속-유기 프레임워크 나노입자를 제조하는 일반적이고 직접적인 방법
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
EP3661506A4
(en)
|
2017-07-31 |
2021-04-21 |
Washington University |
PIRFENIDONE DERIVATIVES FOR MODULATION OF B LYMPHOCYTE ACTIVITY AND ORGAN PROTECTION
|
EP3668497A4
(en)
|
2017-08-14 |
2021-04-28 |
Washington University |
METHODS AND COMPOSITIONS FOR TREATMENT OF CANCER, INFLAMMATION, OR IMMUNE-REACTION-ASSOCIATED DISEASES
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
US11097018B2
(en)
|
2017-09-06 |
2021-08-24 |
Washington University |
Organomedicinals for imaging and treatment of neurodegenerative disorders
|
WO2019055460A1
(en)
|
2017-09-13 |
2019-03-21 |
The Children's Medical Center Corporation |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TRANSPOSON-ASSOCIATED DISEASES
|
US11618896B2
(en)
|
2017-09-21 |
2023-04-04 |
The Broad Institute, Inc. |
Systems, methods, and compositions for targeted nucleic acid editing
|
CN111757937A
(zh)
|
2017-10-16 |
2020-10-09 |
布罗德研究所股份有限公司 |
腺苷碱基编辑器的用途
|
EP3697910A4
(en)
|
2017-10-18 |
2021-07-14 |
Sarepta Therapeutics, Inc. |
ANTISENSE OLIGOMERIC COMPOUNDS
|
WO2019089922A1
(en)
|
2017-11-01 |
2019-05-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
US11851679B2
(en)
|
2017-11-01 |
2023-12-26 |
Juno Therapeutics, Inc. |
Method of assessing activity of recombinant antigen receptors
|
CN107827762B
(zh)
*
|
2017-11-14 |
2020-10-02 |
苏州东南药业股份有限公司 |
一种(2,3-二油酰基-丙基)三甲基氯化铵及其制备方法和用途
|
SG11202004457XA
(en)
|
2017-11-17 |
2020-06-29 |
Iovance Biotherapeutics Inc |
Til expansion from fine needle aspirates and small biopsies
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
CA3083118A1
(en)
|
2017-11-22 |
2019-05-31 |
Iovance Biotherapeutics, Inc. |
Expansion of peripheral blood lymphocytes (pbls) from peripheral blood
|
WO2019118806A1
(en)
|
2017-12-14 |
2019-06-20 |
Solid Biosciences Inc. |
Non-viral production and delivery of genes
|
AU2018392782B2
(en)
|
2017-12-21 |
2023-08-31 |
Alnylam Pharmaceuticals, Inc. |
Chirally-enriched double-stranded RNA agents
|
US11713446B2
(en)
|
2018-01-08 |
2023-08-01 |
Iovance Biotherapeutics, Inc. |
Processes for generating TIL products enriched for tumor antigen-specific T-cells
|
EP3737743A1
(en)
|
2018-01-08 |
2020-11-18 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
WO2019136459A1
(en)
|
2018-01-08 |
2019-07-11 |
Iovance Biotherapeutics, Inc. |
Processes for generating til products enriched for tumor antigen-specific t-cells
|
BR112020013626A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
compostos de quinoxalinona, composições, métodos e kits para aumentar a eficiência de edição de genoma
|
BR112020014140A2
(pt)
|
2018-01-17 |
2020-12-01 |
Vertex Pharmaceuticals Incorporated |
inibidores de dna-pk
|
IL276080B2
(en)
|
2018-01-17 |
2023-10-01 |
Vertex Pharma |
DNA-PK suppressor compounds, UTP-containing preparations and their uses
|
WO2019144117A1
(en)
|
2018-01-22 |
2019-07-25 |
Bioventures, Llc |
Bcl-2 proteins degraders for cancer treatment
|
KR20200115567A
(ko)
|
2018-01-29 |
2020-10-07 |
머크 샤프 앤드 돔 코포레이션 |
안정화된 rsv f 단백질 및 그의 용도
|
CN108129338A
(zh)
*
|
2018-02-01 |
2018-06-08 |
爱斯特(成都)生物制药股份有限公司 |
一种阳性脂质体dotap的制备方法
|
WO2019160383A1
(ko)
|
2018-02-19 |
2019-08-22 |
고려대학교 산학협력단 |
열충격단백질의 에피토프를 포함하는 백신 및 이의 용도
|
EP3539975A1
(en)
|
2018-03-15 |
2019-09-18 |
Fundació Privada Institut d'Investigació Oncològica de Vall-Hebron |
Micropeptides and uses thereof
|
JP7460534B2
(ja)
|
2018-03-30 |
2024-04-02 |
インスメッド インコーポレイテッド |
リポソーム医薬品の連続製造方法
|
CN112272516B
(zh)
|
2018-04-06 |
2023-05-30 |
儿童医疗中心有限公司 |
用于体细胞重新编程和调整印记的组合物和方法
|
US20210363547A1
(en)
|
2018-05-06 |
2021-11-25 |
Emendobio Inc. |
Differential knockout of an allele of a heterozygous elane gene
|
US12084423B2
(en)
|
2018-05-18 |
2024-09-10 |
Bioventures, Llc |
Piperlongumine analogues and uses thereof
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
EP3802807A1
(en)
|
2018-06-05 |
2021-04-14 |
Lifeedit, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
WO2020033601A1
(en)
|
2018-08-07 |
2020-02-13 |
The Broad Institute, Inc. |
Novel cas12b enzymes and systems
|
US20210317461A1
(en)
|
2018-08-09 |
2021-10-14 |
Verseau Therapeutics, Inc. |
Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
|
KR20210043623A
(ko)
|
2018-08-10 |
2021-04-21 |
주식회사 유틸렉스 |
Hla-dr에 결합하는 키메라 항원 수용체 및 car-t 세포
|
US20210317429A1
(en)
|
2018-08-20 |
2021-10-14 |
The Broad Institute, Inc. |
Methods and compositions for optochemical control of crispr-cas9
|
CN118421617A
(zh)
|
2018-08-24 |
2024-08-02 |
川斯勒佰尔公司 |
用于纯化信使rna的方法
|
KR20210060533A
(ko)
|
2018-09-18 |
2021-05-26 |
상가모 테라퓨틱스, 인코포레이티드 |
프로그램화된 세포 사멸 1 (pd1) 특이적 뉴클레아제
|
WO2020060986A1
(en)
|
2018-09-18 |
2020-03-26 |
Alnylam Pharmaceuticals, Inc. |
Ketohexokinase (khk) irna compositions and methods of use thereof
|
WO2020069029A1
(en)
|
2018-09-26 |
2020-04-02 |
Emendobio Inc. |
Novel crispr nucleases
|
AU2019347666A1
(en)
|
2018-09-28 |
2021-03-25 |
President And Fellows Of Harvard College |
Cellular reprogramming to reverse aging and promote organ and tissue regeneration
|
GB201815820D0
(en)
|
2018-09-28 |
2018-11-14 |
Univ Wageningen |
Off-target activity inhibitors for guided endonucleases
|
EP3867375A1
(en)
|
2018-10-15 |
2021-08-25 |
Fondazione Telethon |
Genome editing methods and constructs
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
JP2022506508A
(ja)
|
2018-11-05 |
2022-01-17 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
Akt経路阻害剤を利用したtilの拡大培養
|
CN112969469A
(zh)
|
2018-11-05 |
2021-06-15 |
艾欧凡斯生物治疗公司 |
抗pd-1抗体难治性nsclc患者的治疗
|
PE20211292A1
(es)
|
2018-11-05 |
2021-07-20 |
Iovance Biotherapeutics Inc |
Procesos para la produccion de linfocitos infiltrantes de tumor y usos de estos en inmunoterapia
|
BR112021008266A2
(pt)
|
2018-11-05 |
2022-01-04 |
Iovance Biotherapeutics Inc |
Métodos para expandir linfócitos infiltrantes de tumor em uma população terapêutica de linfócitos infiltrantes de tumor e para tratar um sujeito com câncer, e, população terapêutica de linfócitos infiltrantes de tumor
|
US20220282275A1
(en)
|
2018-11-15 |
2022-09-08 |
The Broad Institute, Inc. |
G-to-t base editors and uses thereof
|
WO2020117840A2
(en)
|
2018-12-05 |
2020-06-11 |
Empirico Inc. |
Process to inhibit or eliminate eosinophilic diseases of the airway and related conditions
|
CA3124110A1
(en)
|
2018-12-17 |
2020-06-25 |
The Broad Institute, Inc. |
Crispr-associated transposase systems and methods of use thereof
|
JP2022514023A
(ja)
|
2018-12-19 |
2022-02-09 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
操作されたサイトカイン受容体対を使用して腫瘍浸潤リンパ球を拡大培養する方法及びその使用
|
JP2022515744A
(ja)
|
2018-12-20 |
2022-02-22 |
プラクシス プレシジョン メディシンズ, インコーポレイテッド |
Kcnt1関連障害の治療のための組成物及び方法
|
BR112021012665A2
(pt)
|
2018-12-27 |
2021-11-03 |
Lifeedit Therapeutics Inc |
Polipeptídeos úteis para edição de genes e métodos de uso
|
US11116778B2
(en)
|
2019-01-15 |
2021-09-14 |
Empirico Inc. |
Prodrugs of ALOX-15 inhibitors and methods of using the same
|
WO2020163379A1
(en)
|
2019-02-05 |
2020-08-13 |
Emendobio Inc. |
Crispr compositions and methods for promoting gene editing of ribosomal protein s19 (rps19) gene
|
WO2020163017A1
(en)
|
2019-02-06 |
2020-08-13 |
Klogenix Llc |
Dna binding proteins and uses thereof
|
US20220154157A1
(en)
|
2019-02-06 |
2022-05-19 |
Emendobio Inc. |
New engineered high fidelity cas9
|
US20230053540A1
(en)
|
2019-02-19 |
2023-02-23 |
Massachusetts Institute Of Technology |
Treatment of liver injury
|
JP2022522473A
(ja)
|
2019-03-01 |
2022-04-19 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
液性腫瘍からの腫瘍浸潤リンパ球の拡大培養及びその治療的使用
|
TW202100550A
(zh)
|
2019-03-03 |
2021-01-01 |
愛爾蘭商普羅帝納生物科學公司 |
識別tau之抗體
|
WO2020181193A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenosine methylation
|
WO2020181195A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through adenine excision
|
WO2020181180A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to c:g base editors and uses thereof
|
WO2020181202A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
A:t to t:a base editing through adenine deamination and oxidation
|
WO2020181178A1
(en)
|
2019-03-06 |
2020-09-10 |
The Broad Institute, Inc. |
T:a to a:t base editing through thymine alkylation
|
EP3935077A1
(en)
|
2019-03-08 |
2022-01-12 |
Obsidian Therapeutics, Inc. |
Cd40l compositions and methods for tunable regulation
|
GB201903499D0
(en)
|
2019-03-14 |
2019-05-01 |
Ucl Business Plc |
Minimal promoter
|
WO2020191102A1
(en)
|
2019-03-18 |
2020-09-24 |
The Broad Institute, Inc. |
Type vii crispr proteins and systems
|
WO2020191249A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
WO2020205838A1
(en)
|
2019-04-02 |
2020-10-08 |
Sangamo Therapeutics, Inc. |
Methods for the treatment of beta-thalassemia
|
US11964001B2
(en)
|
2019-04-09 |
2024-04-23 |
Washington University |
Compositions for treating or preventing respiratory tract infections and method of use thereof
|
KR20210154176A
(ko)
|
2019-04-09 |
2021-12-20 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
표적화된 생체내 후성유전학적 억제에 의한 장기지속성 진통
|
WO2020210751A1
(en)
|
2019-04-12 |
2020-10-15 |
The Broad Institute, Inc. |
System for genome editing
|
EP3956349A1
(en)
|
2019-04-17 |
2022-02-23 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
CA3137727A1
(en)
|
2019-04-22 |
2020-10-29 |
The Penn State Research Foundation |
Methods and compositions relating to inhibition of aldehyde dehydrogenases for treatment of cancer
|
US20220213469A1
(en)
|
2019-04-30 |
2022-07-07 |
The Broad Institute, Inc. |
Methods and compositions for barcoding nucleic acid libraries and cell populations
|
WO2020232029A1
(en)
|
2019-05-13 |
2020-11-19 |
Iovance Biotherapeutics, Inc. |
Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy
|
US20220249701A1
(en)
|
2019-05-14 |
2022-08-11 |
The Broad Institute, Inc. |
Compositions and methods for targeting multinucleated cells
|
AU2020279101A1
(en)
|
2019-05-17 |
2021-11-18 |
Alnylam Pharmaceuticals, Inc. |
Oral delivery of oligonucleotides
|
WO2020236982A1
(en)
|
2019-05-20 |
2020-11-26 |
The Broad Institute, Inc. |
Aav delivery of nucleobase editors
|
US20220220469A1
(en)
|
2019-05-20 |
2022-07-14 |
The Broad Institute, Inc. |
Non-class i multi-component nucleic acid targeting systems
|
US20220226464A1
(en)
|
2019-05-28 |
2022-07-21 |
Massachusetts Institute Of Technology |
Methods and compositions for modulating immune responses
|
EP4166671A1
(en)
|
2019-05-29 |
2023-04-19 |
Altria Client Services LLC |
Compositions and methods for producing tobacco plants and products having reduced or eliminated suckers
|
WO2020243485A1
(en)
|
2019-05-29 |
2020-12-03 |
Massachusetts Institute Of Technology |
Hiv-1 specific immunogen compositions and methods of use
|
PE20220256A1
(es)
|
2019-06-07 |
2022-02-21 |
Scribe Therapeutics Inc |
Sistemas de casx artificiales
|
GB201909597D0
(en)
|
2019-07-03 |
2019-08-14 |
Univ Wageningen |
Crispr type v-u1 system from mycobacterium mucogenicum and uses thereof
|
MX2022000922A
(es)
|
2019-07-23 |
2022-05-03 |
Mnemo Therapeutics |
Celulas inmunes defectuosas para suv39h1.
|
US20220315906A1
(en)
|
2019-08-08 |
2022-10-06 |
The Broad Institute, Inc. |
Base editors with diversified targeting scope
|
US20220364074A1
(en)
|
2019-08-12 |
2022-11-17 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
EP4013870A1
(en)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
|
WO2021030666A1
(en)
|
2019-08-15 |
2021-02-18 |
The Broad Institute, Inc. |
Base editing by transglycosylation
|
CN115023499A
(zh)
|
2019-08-16 |
2022-09-06 |
麻省理工学院 |
使用CRISPR/Cas13的靶向反式剪接
|
KR102099342B1
(ko)
|
2019-09-03 |
2020-04-10 |
주식회사 제노포커스 |
Crm197 단백질 발현 방법
|
WO2021072328A1
(en)
|
2019-10-10 |
2021-04-15 |
The Broad Institute, Inc. |
Methods and compositions for prime editing rna
|
JP2022553642A
(ja)
|
2019-10-10 |
2022-12-26 |
アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー |
タバコにおける淡黄色遺伝子座およびその応用
|
TW202132567A
(zh)
|
2019-11-01 |
2021-09-01 |
美商阿尼拉製藥公司 |
亨汀頓蛋白(HTT)iRNA劑組成物及其使用方法
|
EP4051322A1
(en)
|
2019-11-01 |
2022-09-07 |
Sangamo Therapeutics, Inc. |
Compositions and methods for genome engineering
|
CN115135765A
(zh)
|
2019-11-08 |
2022-09-30 |
菲奥医药公司 |
用于免疫治疗的靶向含布罗莫结构域之蛋白4(brd4)的经化学修饰的寡核苷酸
|
EP4061945A1
(en)
|
2019-11-22 |
2022-09-28 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
US20230086199A1
(en)
|
2019-11-26 |
2023-03-23 |
The Broad Institute, Inc. |
Systems and methods for evaluating cas9-independent off-target editing of nucleic acids
|
CA3161104A1
(en)
|
2019-12-11 |
2021-06-17 |
Cecile Chartier-Courtaud |
Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same
|
TW202140509A
(zh)
|
2019-12-13 |
2021-11-01 |
美商阿尼拉製藥公司 |
人類染色體9開讀框72(C9ORF72)iRNA劑組成物及其使用方法
|
KR20220143005A
(ko)
|
2019-12-20 |
2022-10-24 |
노바록 바이오테라퓨틱스 리미티드 |
항-인터루킨-23 p19 항체 및 이의 사용 방법
|
WO2021138247A1
(en)
|
2019-12-30 |
2021-07-08 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
EP4085136A1
(en)
|
2019-12-31 |
2022-11-09 |
Phio Pharmaceuticals Corp. |
Chemically modified oligonucleotides with improved systemic delivery
|
JP2023509770A
(ja)
|
2020-01-08 |
2023-03-09 |
オブシディアン セラピューティクス, インコーポレイテッド |
転写の調節可能な制御のための組成物及び方法
|
GB202000934D0
(en)
|
2020-01-22 |
2020-03-04 |
Ucl Business Ltd |
Engineered immune cells
|
EP4097124A1
(en)
|
2020-01-28 |
2022-12-07 |
The Broad Institute Inc. |
Base editors, compositions, and methods for modifying the mitochondrial genome
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
US20230235309A1
(en)
|
2020-02-05 |
2023-07-27 |
The Broad Institute, Inc. |
Adenine base editors and uses thereof
|
WO2021158999A1
(en)
|
2020-02-05 |
2021-08-12 |
The Broad Institute, Inc. |
Gene editing methods for treating spinal muscular atrophy
|
WO2021163191A1
(en)
|
2020-02-10 |
2021-08-19 |
Board Of Regents, The University Of Texas System |
Methods for rapid cloning and expression of hla class i cells
|
EP4103687A4
(en)
|
2020-02-11 |
2024-03-20 |
Tenza, Inc. |
BIOTHERAPEUTICS FOR THE DETECTION, DIAGNOSIS AND TREATMENT OF DISEASES ASSOCIATED WITH MUCOUS BLEEDING
|
WO2021163002A1
(en)
|
2020-02-14 |
2021-08-19 |
Merck Sharp & Dohme Corp. |
Hpv vaccine
|
US11752199B1
(en)
|
2020-02-25 |
2023-09-12 |
Mallinckrodt Ard Ip Unlimited Company |
Methods of modulating pericytes
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
EP3885440A1
(en)
|
2020-03-26 |
2021-09-29 |
Splicebio, S.L. |
Split inteins and their uses
|
JP2023519274A
(ja)
|
2020-03-26 |
2023-05-10 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
コロナウイルスiRNA組成物およびその使用方法
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
TW202208626A
(zh)
|
2020-04-24 |
2022-03-01 |
美商生命編輯公司 |
Rna引導核酸酶及其活性片段與變體,以及使用方法
|
BR112022021813A2
(pt)
|
2020-04-27 |
2023-01-17 |
Alnylam Pharmaceuticals Inc |
Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
|
WO2021222318A1
(en)
|
2020-04-28 |
2021-11-04 |
The Broad Institute, Inc. |
Targeted base editing of the ush2a gene
|
TW202208617A
(zh)
|
2020-05-04 |
2022-03-01 |
美商艾歐凡斯生物治療公司 |
用於產生腫瘤浸潤性淋巴球的過程及其在免疫療法中的用途
|
CN111393595A
(zh)
*
|
2020-05-06 |
2020-07-10 |
东莞市竤穗实业投资有限公司 |
一种具有温敏特性的生物基聚碳化二亚胺交联剂及其制备方法
|
EP4146284A1
(en)
|
2020-05-06 |
2023-03-15 |
Cellectis S.A. |
Methods to genetically modify cells for delivery of therapeutic proteins
|
JP2023525513A
(ja)
|
2020-05-06 |
2023-06-16 |
セレクティス ソシエテ アノニム |
細胞ゲノムにおける外因性配列の標的化挿入のための方法
|
MX2022014008A
(es)
|
2020-05-08 |
2023-02-09 |
Broad Inst Inc |
Métodos y composiciones para la edición simultánea de ambas cadenas de una secuencia de nucleótidos de doble cadena objetivo.
|
WO2021231437A1
(en)
|
2020-05-11 |
2021-11-18 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleic acid binding proteins and active fragments and variants thereof and methods of use
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
EP4150087A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
WO2021231691A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi)
|
WO2021231675A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
WO2021231673A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
EP4150078A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
WO2021231692A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
EP4150077A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
KR20230037501A
(ko)
|
2020-05-19 |
2023-03-16 |
오타이르 프로테나 리미티드 |
알츠하이머병 치료용 멀티에피토프 백신
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
IL299329A
(en)
|
2020-06-24 |
2023-02-01 |
Prothena Biosciences Ltd |
Antibodies recognizing sortilin
|
AU2021305665A1
(en)
|
2020-07-10 |
2023-02-23 |
Centre National De La Recherche Scientifique |
Methods and compositions for treating epilepsy
|
JP2023534693A
(ja)
|
2020-07-15 |
2023-08-10 |
ライフエディット セラピューティクス,インコーポレイティド |
ウラシル安定化タンパク質並びにその活性断片及びバリアント並びに使用方法
|
AU2021316727A1
(en)
|
2020-07-30 |
2023-03-02 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Immune cells defective for SOCS1
|
WO2022034374A2
(en)
|
2020-08-11 |
2022-02-17 |
University Of Oslo |
Improved gene editing
|
WO2022046760A2
(en)
|
2020-08-25 |
2022-03-03 |
Kite Pharma, Inc. |
T cells with improved functionality
|
JP2023540526A
(ja)
|
2020-09-04 |
2023-09-25 |
ノヴァロック バイオセラピューティクス, リミテッド |
ネクチン-4抗体およびそれの使用
|
AU2021338707A1
(en)
|
2020-09-10 |
2023-04-06 |
Monsanto Technology Llc |
Increasing gene editing and site-directed integration events utilizing meiotic and germline promoters
|
KR20230084505A
(ko)
|
2020-09-11 |
2023-06-13 |
라이프에디트 테라퓨틱스, 인크. |
Dna 변형 효소 및 그의 활성 단편 및 변이체 및 사용 방법
|
US20230348892A1
(en)
|
2020-09-17 |
2023-11-02 |
Northwestern University |
Engineered mamalian genetic circuits and methods of using the same
|
WO2022066847A1
(en)
|
2020-09-24 |
2022-03-31 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
EP3973978A1
(en)
|
2020-09-25 |
2022-03-30 |
Mallinckrodt Ard IP Unlimited Company |
Methods of modulating corticosteroid response
|
JP2023544413A
(ja)
|
2020-10-05 |
2023-10-23 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
Gタンパク質共役受容体75(GPR75)iRNA組成物およびその使用方法
|
JP2023546359A
(ja)
|
2020-10-06 |
2023-11-02 |
アイオバンス バイオセラピューティクス,インコーポレイテッド |
腫瘍浸潤リンパ球療法によるnsclc患者の治療
|
WO2022076606A1
(en)
|
2020-10-06 |
2022-04-14 |
Iovance Biotherapeutics, Inc. |
Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
|
US20230390371A1
(en)
|
2020-10-16 |
2023-12-07 |
Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis |
Anti-tumor immunity induces the presentation of aberrant peptides
|
CA3198823A1
(en)
|
2020-10-21 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
WO2022087329A1
(en)
|
2020-10-23 |
2022-04-28 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
EP4251170A1
(en)
|
2020-11-25 |
2023-10-04 |
Akagera Medicines, Inc. |
Lipid nanoparticles for delivery of nucleic acids, and related methods of use
|
WO2022119873A1
(en)
|
2020-12-01 |
2022-06-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
AU2021401302A1
(en)
|
2020-12-17 |
2023-07-06 |
Iovance Biotherapeutics, Inc. |
Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
|
EP4262827A1
(en)
|
2020-12-17 |
2023-10-25 |
Iovance Biotherapeutics, Inc. |
Treatment of cancers with tumor infiltrating lymphocytes
|
CA3203876A1
(en)
|
2021-01-11 |
2022-07-14 |
David R. Liu |
Prime editor variants, constructs, and methods for enhancing prime editing efficiency and precision
|
EP4284925A1
(en)
|
2021-01-26 |
2023-12-06 |
California Institute of Technology |
Allosteric conditional guide rnas for cell-selective regulation of crispr/cas
|
EP4284923A1
(en)
|
2021-01-29 |
2023-12-06 |
Wageningen Universiteit |
Crispr-associated base-editing of the complementary strand
|
JP2024505756A
(ja)
|
2021-02-03 |
2024-02-07 |
アルトリア クライアント サーヴィシーズ リミテッド ライアビリティ カンパニー |
植物毛状突起における毛状突起密度の増加および代謝物の輸送の改善の方法
|
TW202245835A
(zh)
|
2021-02-04 |
2022-12-01 |
美商默沙東有限責任公司 |
用於肺炎球菌結合物疫苗之奈米乳化液佐劑組合物
|
KR20230146048A
(ko)
|
2021-02-12 |
2023-10-18 |
알닐람 파마슈티칼스 인코포레이티드 |
슈퍼옥사이드 디스뮤타제 1(sod1) irna 조성물 및 슈퍼옥사이드 디스뮤타제 1- (sod1-) 관련 신경퇴행성 질환을 치료하거나 예방하기 위한 이의 사용 방법
|
WO2022182864A1
(en)
|
2021-02-25 |
2022-09-01 |
Alnylam Pharmaceuticals, Inc. |
Prion protein (prnp) irna compositions and methods and methods of use thereof
|
EP4305169A1
(en)
|
2021-03-12 |
2024-01-17 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
WO2022192789A1
(en)
|
2021-03-12 |
2022-09-15 |
Synthego Corporation |
Genetically modified cells expressing antigen-containing fusion proteins and uses thereof
|
US20240301385A1
(en)
|
2021-03-22 |
2024-09-12 |
LifeEDIT Therapeutics, Inc. |
Dna modifying enzymes and active fragments and variants thereof and methods of use
|
MX2023011466A
(es)
|
2021-03-29 |
2024-02-01 |
Alnylam Pharmaceuticals Inc |
Composiciones de agentes de ácido ribonucleico de interferencia (arni) de huntingtina (htt) y métodos de uso de estas.
|
CA3215830A1
(en)
|
2021-04-19 |
2022-10-27 |
Rafael CUBAS |
Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
|
WO2022226291A1
(en)
|
2021-04-22 |
2022-10-27 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for treating cancer
|
EP4330396A1
(en)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
EP4341401A1
(en)
|
2021-05-18 |
2024-03-27 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
US20240263177A1
(en)
|
2021-05-20 |
2024-08-08 |
Korro Bio, Inc. |
Methods and Compositions for Adar-Mediated Editing
|
AU2022277649A1
(en)
|
2021-05-21 |
2023-11-30 |
Cellectis S.A. |
Enhancing efficacy of t-cell-mediated immunotherapy by modulating cancer-associated fibroblasts in solid tumors
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
KR20240017911A
(ko)
|
2021-06-04 |
2024-02-08 |
알닐람 파마슈티칼스 인코포레이티드 |
인간 염색체 9 개방 해독 프레임 72(C9orf72) iRNA 제제 조성물 및 이의 사용 방법
|
US20240287487A1
(en)
|
2021-06-11 |
2024-08-29 |
The Broad Institute, Inc. |
Improved cytosine to guanine base editors
|
EP4352215A1
(en)
|
2021-06-11 |
2024-04-17 |
LifeEDIT Therapeutics, Inc. |
Rna polymerase iii promoters and methods of use
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
EP4363574A1
(en)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
WO2023288288A1
(en)
|
2021-07-15 |
2023-01-19 |
Turn Biotechnologies, Inc. |
Synthetic, persistent rna constructs with on/off mechanism for controlled expression and methods of use
|
WO2023288285A1
(en)
|
2021-07-15 |
2023-01-19 |
Turn Biotechnologies, Inc. |
Polycistronic expression vectors
|
WO2023288287A2
(en)
|
2021-07-15 |
2023-01-19 |
Turn Biotechnologies, Inc. |
Synthetic, persistent rna constructs and methods of use for cell rejuvenation and for treatment
|
GB202110644D0
(en)
|
2021-07-23 |
2021-09-08 |
Sisaf Ltd |
Improved nucleic acid vector particles
|
GB202110646D0
(en)
|
2021-07-23 |
2021-09-08 |
Sisaf Ltd |
Nucleic acid vector compositions
|
TW202325312A
(zh)
|
2021-07-23 |
2023-07-01 |
美商艾拉倫製藥股份有限公司 |
β-鏈蛋白(CTNNB1)iRNA組成物及其使用方法
|
WO2023009716A1
(en)
|
2021-07-28 |
2023-02-02 |
Iovance Biotherapeutics, Inc. |
Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
|
WO2023015264A1
(en)
|
2021-08-04 |
2023-02-09 |
Phio Pharmaceuticals Corp. |
Immunotherapy of cancer utilizing natural killer cells treated with chemically modified oligonucleotides
|
JP2024529025A
(ja)
|
2021-08-04 |
2024-08-01 |
フィオ ファーマシューティカルズ コーポレーション |
化学修飾されたオリゴヌクレオチド
|
JP2024530487A
(ja)
|
2021-08-06 |
2024-08-21 |
ザ ブロード インスティテュート,インコーポレーテッド |
改善されたプライムエディターおよび使用方法
|
WO2023023152A1
(en)
|
2021-08-19 |
2023-02-23 |
Merck Sharp & Dohme Llc |
Thermostable lipid nanoparticle and methods of use thereof
|
CN118302185A
(zh)
|
2021-10-01 |
2024-07-05 |
荷兰皇家科学院 |
哺乳动物心脏再生
|
KR20240090727A
(ko)
|
2021-10-22 |
2024-06-21 |
세일 바이오메디슨스, 인크. |
Mrna 백신 조성물
|
AU2022370009A1
(en)
|
2021-10-22 |
2024-05-16 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
WO2023076898A1
(en)
|
2021-10-25 |
2023-05-04 |
The Broad Institute, Inc. |
Methods and compositions for editing a genome with prime editing and a recombinase
|
AR127482A1
(es)
|
2021-10-27 |
2024-01-31 |
Iovance Biotherapeutics Inc |
Sistemas y métodos para coordinar la fabricación de células para inmunoterapia específica de paciente
|
EP4423272A2
(en)
|
2021-10-29 |
2024-09-04 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
AU2022375820A1
(en)
|
2021-11-01 |
2024-06-13 |
Tome Biosciences, Inc. |
Single construct platform for simultaneous delivery of gene editing machinery and nucleic acid cargo
|
CN114015674B
(zh)
|
2021-11-02 |
2024-08-30 |
辉大(上海)生物科技有限公司 |
一种CRISPR-Cas12i系统
|
WO2023080788A1
(en)
|
2021-11-05 |
2023-05-11 |
Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis |
Tryptophan depletion induces production and presentation of tryptophan to phenylalanine substitutions
|
WO2023086803A1
(en)
|
2021-11-10 |
2023-05-19 |
Iovance Biotherapeutics, Inc. |
Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes
|
WO2023096858A1
(en)
|
2021-11-23 |
2023-06-01 |
Senda Biosciences, Inc. |
A bacteria-derived lipid composition and use thereof
|
WO2023096494A1
(en)
|
2021-11-26 |
2023-06-01 |
Synvolux Ip B.V. |
Conserved coronavirus t cell epitopes
|
WO2023122080A1
(en)
|
2021-12-20 |
2023-06-29 |
Senda Biosciences, Inc. |
Compositions comprising mrna and lipid reconstructed plant messenger packs
|
IL313660A
(en)
|
2021-12-22 |
2024-08-01 |
Camp4 Therapeutics Corp |
Modulation of gene transcription using antisense oligonucleotides targeting regulatory RNAs
|
WO2023122764A1
(en)
|
2021-12-22 |
2023-06-29 |
Tome Biosciences, Inc. |
Co-delivery of a gene editor construct and a donor template
|
WO2023126458A1
(en)
|
2021-12-28 |
2023-07-06 |
Mnemo Therapeutics |
Immune cells with inactivated suv39h1 and modified tcr
|
AU2023208961A1
(en)
|
2022-01-24 |
2024-09-12 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
WO2023150637A1
(en)
|
2022-02-02 |
2023-08-10 |
Inscripta, Inc. |
Nucleic acid-guided nickase fusion proteins
|
WO2023196802A1
(en)
|
2022-04-04 |
2023-10-12 |
The Broad Institute, Inc. |
Cas9 variants having non-canonical pam specificities and uses thereof
|
WO2023196818A1
(en)
|
2022-04-04 |
2023-10-12 |
The Regents Of The University Of California |
Genetic complementation compositions and methods
|
WO2023196851A1
(en)
|
2022-04-06 |
2023-10-12 |
President And Fellows Of Harvard College |
Reversing aging of the central nervous system
|
WO2023201369A1
(en)
|
2022-04-15 |
2023-10-19 |
Iovance Biotherapeutics, Inc. |
Til expansion processes using specific cytokine combinations and/or akti treatment
|
WO2023205744A1
(en)
|
2022-04-20 |
2023-10-26 |
Tome Biosciences, Inc. |
Programmable gene insertion compositions
|
WO2023212715A1
(en)
|
2022-04-28 |
2023-11-02 |
The Broad Institute, Inc. |
Aav vectors encoding base editors and uses thereof
|
WO2023215831A1
(en)
|
2022-05-04 |
2023-11-09 |
Tome Biosciences, Inc. |
Guide rna compositions for programmable gene insertion
|
WO2023220603A1
(en)
|
2022-05-09 |
2023-11-16 |
Regeneron Pharmaceuticals, Inc. |
Vectors and methods for in vivo antibody production
|
WO2023220459A1
(en)
|
2022-05-13 |
2023-11-16 |
Northwestern University |
Active loading of cargo entity into lipid bilayer particles using dimerization domains
|
WO2023220457A1
(en)
|
2022-05-13 |
2023-11-16 |
Northwestern University |
Receptor engagement-mediated enhancement of biologics delivery
|
WO2023220392A1
(en)
|
2022-05-13 |
2023-11-16 |
Northwestern University |
Synthetic modular extracellular sensors that employ natural receptor ligand-binding domains
|
WO2023225670A2
(en)
|
2022-05-20 |
2023-11-23 |
Tome Biosciences, Inc. |
Ex vivo programmable gene insertion
|
EP4279085A1
(en)
|
2022-05-20 |
2023-11-22 |
Mnemo Therapeutics |
Compositions and methods for treating a refractory or relapsed cancer or a chronic infectious disease
|
WO2023230433A1
(en)
|
2022-05-23 |
2023-11-30 |
Altria Client Services Llc |
Methods and compositions for regulating alkaloids in tobacco field
|
US12064479B2
(en)
|
2022-05-25 |
2024-08-20 |
Akagera Medicines, Inc. |
Lipid nanoparticles for delivery of nucleic acids and methods of use thereof
|
WO2023230613A1
(en)
|
2022-05-27 |
2023-11-30 |
The Broad Institute, Inc. |
Improved mitochondrial base editors and methods for editing mitochondrial dna
|
WO2023235392A1
(en)
|
2022-06-02 |
2023-12-07 |
Perkinelmer Health Sciences, Inc. |
Electrophoresis-mediated characterization of dna content of adeno-associated virus capsids
|
WO2023235818A2
(en)
|
2022-06-02 |
2023-12-07 |
Scribe Therapeutics Inc. |
Engineered class 2 type v crispr systems
|
TW202405175A
(zh)
|
2022-06-07 |
2024-02-01 |
美商斯奎柏治療公司 |
用於靶向pcsk9的組合物及方法
|
TW202413643A
(zh)
|
2022-06-07 |
2024-04-01 |
美商斯奎柏治療公司 |
用於靶向pcsk9的組合物及方法
|
WO2023240137A1
(en)
|
2022-06-08 |
2023-12-14 |
The Board Institute, Inc. |
Evolved cas14a1 variants, compositions, and methods of making and using same in genome editing
|
WO2023240277A2
(en)
|
2022-06-10 |
2023-12-14 |
Camp4 Therapeutics Corporation |
Methods of modulating progranulin expression using antisense oligonucleotides targeting regulatory rnas
|
CN115557851B
(zh)
*
|
2022-06-27 |
2023-04-18 |
上海云沂生物医药科技有限公司 |
一种氨基脂质、其合成方法、颗粒及用途
|
WO2024003334A1
(en)
|
2022-06-30 |
2024-01-04 |
Cellectis S.A. |
Enhancing safety of t-cell-mediated immunotherapy
|
WO2024015383A1
(en)
|
2022-07-12 |
2024-01-18 |
Northwestern University |
Engineered hypoxia biosensors and methods of using the same
|
WO2024020587A2
(en)
|
2022-07-22 |
2024-01-25 |
Tome Biosciences, Inc. |
Pleiopluripotent stem cell programmable gene insertion
|
WO2024026474A1
(en)
|
2022-07-29 |
2024-02-01 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
|
WO2024031038A1
(en)
|
2022-08-05 |
2024-02-08 |
Altria Client Services Llc |
Methods and compositions for regulating alkaloids in tobacco
|
WO2024033901A1
(en)
|
2022-08-12 |
2024-02-15 |
LifeEDIT Therapeutics, Inc. |
Rna-guided nucleases and active fragments and variants thereof and methods of use
|
WO2024040083A1
(en)
|
2022-08-16 |
2024-02-22 |
The Broad Institute, Inc. |
Evolved cytosine deaminases and methods of editing dna using same
|
WO2024042489A1
(en)
|
2022-08-25 |
2024-02-29 |
LifeEDIT Therapeutics, Inc. |
Chemical modification of guide rnas with locked nucleic acid for rna guided nuclease-mediated gene editing
|
WO2024047587A1
(en)
|
2022-08-31 |
2024-03-07 |
Regel Therapeutics, Inc. |
Cas-phi compositions and methods of use
|
WO2024059165A1
(en)
|
2022-09-15 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
|
WO2024094775A1
(en)
|
2022-11-03 |
2024-05-10 |
Cellectis S.A. |
Enhancing efficacy and safety of t-cell-mediated immunotherapy
|
WO2024098024A1
(en)
|
2022-11-04 |
2024-05-10 |
Iovance Biotherapeutics, Inc. |
Expansion of tumor infiltrating lymphocytes from liquid tumors and therapeutic uses thereof
|
WO2024095245A2
(en)
|
2022-11-04 |
2024-05-10 |
LifeEDIT Therapeutics, Inc. |
Evolved adenine deaminases and rna-guided nuclease fusion proteins with internal insertion sites and methods of use
|
US20240182561A1
(en)
|
2022-11-04 |
2024-06-06 |
Regeneron Pharmaceuticals, Inc. |
Calcium voltage-gated channel auxiliary subunit gamma 1 (cacng1) binding proteins and cacng1-mediated delivery to skeletal muscle
|
WO2024102434A1
(en)
|
2022-11-10 |
2024-05-16 |
Senda Biosciences, Inc. |
Rna compositions comprising lipid nanoparticles or lipid reconstructed natural messenger packs
|
US20240173426A1
(en)
|
2022-11-14 |
2024-05-30 |
Regeneron Pharmaceuticals, Inc. |
Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
|
WO2024119145A1
(en)
|
2022-12-01 |
2024-06-06 |
Camp4 Therapeutics Corporation |
Modulation of syngap1 gene transcription using antisense oligonucleotides targeting regulatory rnas
|
WO2024127369A1
(en)
|
2022-12-16 |
2024-06-20 |
LifeEDIT Therapeutics, Inc. |
Guide rnas that target foxp3 gene and methods of use
|
WO2024127370A1
(en)
|
2022-12-16 |
2024-06-20 |
LifeEDIT Therapeutics, Inc. |
Guide rnas that target trac gene and methods of use
|
GB202219855D0
(en)
|
2022-12-30 |
2023-02-15 |
Univ Oxford Innovation Ltd |
Affinity capture reagents for mass spectrometry
|
WO2024155597A1
(en)
|
2023-01-17 |
2024-07-25 |
Inscripta, Inc. |
Methods and compositions of co-expression of t7rna polymerase and inhibitory rna aptamers
|
GB202300915D0
(en)
|
2023-01-20 |
2023-03-08 |
Sisaf Ltd |
mRNA COMPOSITIONS
|
WO2024159172A1
(en)
|
2023-01-27 |
2024-08-02 |
Senda Biosciences, Inc. |
A modified lipid composition and uses thereof
|
WO2024163862A2
(en)
|
2023-02-03 |
2024-08-08 |
The Broad Institute, Inc. |
Gene editing methods, systems, and compositions for treating spinal muscular atrophy
|