BR112013019803A2 - método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf) - Google Patents

método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf)

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Publication number
BR112013019803A2
BR112013019803A2 BR112013019803A BR112013019803A BR112013019803A2 BR 112013019803 A2 BR112013019803 A2 BR 112013019803A2 BR 112013019803 A BR112013019803 A BR 112013019803A BR 112013019803 A BR112013019803 A BR 112013019803A BR 112013019803 A2 BR112013019803 A2 BR 112013019803A2
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BR
Brazil
Prior art keywords
ctgf
hypertrophic scars
connective tissue
antisense compounds
tissue development
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Application number
BR112013019803A
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English (en)
Inventor
Hardee Gregory
Gordon Foulkes J
Young Leroy
Krochmal Lincoln
Jewell Mark
O'donnell Niall
M Dean Nicholas
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Excaliard Pharmaceuticals Inc
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Application filed by Excaliard Pharmaceuticals Inc filed Critical Excaliard Pharmaceuticals Inc
Publication of BR112013019803A2 publication Critical patent/BR112013019803A2/pt

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Abstract

método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf) a presente invenção proporciona métodos de evitar formação de, ou tratar, lesões fibróticas, incluindo cicatrizes da pele tais como queloides e cicatrizes hipertróficas que compreendem administrar ao indivíduo por uma ou mais injeção um composto que compreende um oligonucleotídeo modificado, tal como um oligonucleotídeo anti-sentido modificado, sirna, ou oligodeoxiribonucleotídeo, que inibe a expressão de proteína envolvida em fibrose. a dosagem do anti-sentido usando uma técnica com giro intradérmica é também descrita.
BR112013019803A 2011-02-02 2012-02-02 método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf) BR112013019803A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161438879P 2011-02-02 2011-02-02
US201161488666P 2011-05-20 2011-05-20
US201161527821P 2011-08-26 2011-08-26
PCT/US2012/023620 WO2012106508A1 (en) 2011-02-02 2012-02-02 Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (ctgf)

Publications (1)

Publication Number Publication Date
BR112013019803A2 true BR112013019803A2 (pt) 2019-06-11

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Application Number Title Priority Date Filing Date
BR112013019803A BR112013019803A2 (pt) 2011-02-02 2012-02-02 método de tratar quelóides ou cicatrizes hipertróficas usando os compostos anti-sentido objetivando fator de desenvolvimento de tecido conjuntivo (ctgf)

Country Status (19)

Country Link
US (3) US9173894B2 (pt)
EP (1) EP2670411B1 (pt)
JP (3) JP6177692B2 (pt)
KR (1) KR101697396B1 (pt)
CN (1) CN103635197A (pt)
AU (4) AU2012212110A1 (pt)
BR (1) BR112013019803A2 (pt)
CA (1) CA2825059A1 (pt)
DK (1) DK2670411T3 (pt)
ES (1) ES2729956T3 (pt)
HU (1) HUE044178T2 (pt)
IL (1) IL227714B (pt)
MX (1) MX365647B (pt)
PL (1) PL2670411T3 (pt)
PT (1) PT2670411T (pt)
RU (1) RU2608655C2 (pt)
SI (1) SI2670411T1 (pt)
TW (1) TWI593416B (pt)
WO (1) WO2012106508A1 (pt)

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CN110840894B (zh) * 2019-12-19 2020-06-02 温州医科大学附属第一医院 一种复合抗疤痕硅酮喷雾剂及其制备方法
CN111208223B (zh) * 2020-01-13 2023-01-17 浙江大学 心脏死亡后捐献受体术前预警移植肾延迟复功的代谢物
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EP2670411A4 (en) 2014-07-16
IL227714A0 (en) 2013-09-30
SI2670411T1 (sl) 2019-06-28
TW201244724A (en) 2012-11-16
PT2670411T (pt) 2019-06-18
US20170022501A1 (en) 2017-01-26
US9173894B2 (en) 2015-11-03
MX2013008963A (es) 2014-01-08
MX365647B (es) 2019-06-10
PL2670411T3 (pl) 2019-09-30
IL227714B (en) 2018-11-29

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