MX2010003720A - Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer. - Google Patents

Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.

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Publication number
MX2010003720A
MX2010003720A MX2010003720A MX2010003720A MX2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A MX 2010003720 A MX2010003720 A MX 2010003720A
Authority
MX
Mexico
Prior art keywords
dendritic cells
cancer
treatment
engineered dendritic
provides
Prior art date
Application number
MX2010003720A
Other languages
English (en)
Inventor
J Mark Braughler
Prasanna Kumar
Walter J Storkus
Hideho Okada
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of MX2010003720A publication Critical patent/MX2010003720A/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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    • A—HUMAN NECESSITIES
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Abstract

Esta invención proporciona el campo de productos terapéuticos. De manera más específica, la presente invención proporciona métodos para generar in vitro células dendríticas creadas por ingeniería genética que expresan de manera condicional interleucina-12 (IL-12) bajo el control de un sistema de modulación de expresión génica en la presencia del ligando activador y usos para propósitos terapéuticos en animales incluyendo humanos.
MX2010003720A 2007-10-08 2008-10-08 Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer. MX2010003720A (es)

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US97839407P 2007-10-08 2007-10-08
US97822407P 2007-10-08 2007-10-08
US97850907P 2007-10-09 2007-10-09
US97948007P 2007-10-12 2007-10-12
US97948507P 2007-10-12 2007-10-12
US99016707P 2007-11-26 2007-11-26
US99068907P 2007-11-28 2007-11-28
US99180707P 2007-12-03 2007-12-03
US1908908P 2008-01-04 2008-01-04
PCT/US2008/011563 WO2009048560A1 (en) 2007-10-08 2008-10-08 Engineered dendritic cells and uses for the treatment of cancer

Publications (1)

Publication Number Publication Date
MX2010003720A true MX2010003720A (es) 2010-10-20

Family

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Application Number Title Priority Date Filing Date
MX2010003720A MX2010003720A (es) 2007-10-08 2008-10-08 Celulas dendriticas creadas por ingenieria genetica y usos para el tratamiento de cancer.

Country Status (17)

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US (4) US20090123441A1 (es)
EP (2) EP2207874B1 (es)
JP (3) JP2010539993A (es)
KR (3) KR101740205B1 (es)
CN (1) CN101883845B (es)
AU (1) AU2008311292B9 (es)
BR (1) BRPI0818287A2 (es)
CA (1) CA2702058A1 (es)
ES (2) ES2531522T3 (es)
HK (1) HK1146300A1 (es)
HU (2) HUE035406T2 (es)
IL (1) IL204841A (es)
MX (1) MX2010003720A (es)
NZ (1) NZ585190A (es)
RU (3) RU2484132C2 (es)
WO (1) WO2009048560A1 (es)
ZA (1) ZA201003163B (es)

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MX2010001993A (es) * 2007-08-23 2010-03-11 Intrexon Corp Metodos y composiciones para diagnosticar una enfermedad.
CA2715080C (en) * 2007-09-28 2021-09-28 Intrexon Corporation Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof
EP2207874B1 (en) * 2007-10-08 2014-12-03 Intrexon Corporation Engineered dendritic cells and uses for the treatment of cancer
BRPI0920679A2 (pt) 2008-10-08 2022-05-17 Intrexon Corp Células construídas expressando múltiplos imunomoduladores e usos das mesmas
PL2534242T3 (pl) * 2010-02-10 2016-11-30 Polepszona kompozycja do hamowania proliferacji komórek nowotworowych
TWI688395B (zh) * 2010-03-23 2020-03-21 英翠克頌公司 條件性表現治療性蛋白質之載體、包含該載體之宿主細胞及彼等之用途
EP3238782A3 (en) * 2010-04-06 2018-01-03 ExoCyte Therapeutics Pte, LTD Methods of treating cancer
CN102026031B (zh) * 2010-12-28 2013-09-04 张朝晖 一种机顶盒
CN102174479B (zh) * 2011-03-02 2013-04-03 北京锤特生物科技有限公司 靶向性治疗人肿瘤的溶肿瘤腺病毒及其应用
EP2681327B1 (en) * 2011-03-04 2018-11-21 Intrexon Corporation Vectors conditionally expressing protein
TWI586640B (zh) * 2011-09-08 2017-06-11 英翠克頌公司 結晶狀二醯基肼及其用途
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