BRPI0920679A2 - Células construídas expressando múltiplos imunomoduladores e usos das mesmas - Google Patents
Células construídas expressando múltiplos imunomoduladores e usos das mesmasInfo
- Publication number
- BRPI0920679A2 BRPI0920679A2 BRPI0920679A BRPI0920679A BRPI0920679A2 BR PI0920679 A2 BRPI0920679 A2 BR PI0920679A2 BR PI0920679 A BRPI0920679 A BR PI0920679A BR PI0920679 A BRPI0920679 A BR PI0920679A BR PI0920679 A2 BRPI0920679 A2 BR PI0920679A2
- Authority
- BR
- Brazil
- Prior art keywords
- immunomodulators
- expressing multiple
- cells constructed
- constructed expressing
- multiple immunomodulators
- Prior art date
Links
- 239000002955 immunomodulating agent Substances 0.000 title abstract 3
- 229940121354 immunomodulator Drugs 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 102000013462 Interleukin-12 Human genes 0.000 abstract 1
- 108010065805 Interleukin-12 Proteins 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000014509 gene expression Effects 0.000 abstract 1
- 210000002865 immune cell Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 229940117681 interleukin-12 Drugs 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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Abstract
células construídas expressando múltiplos imunomoduladores e usos das mesmas. esta invenção refere-se ao campo de produtos terapêuticos. mais especificamente, a invenção fornece métodos de gerar células imunes construídas in vitro, as quais expressam condicionalmente interleucina-12 (il-12) e um ou mais imunomoduladores sob o controle de um sistema de modulação de expressão gênica na presença de ligante de ativação e usos para propósitos terapêuticos em animais.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10381008P | 2008-10-08 | 2008-10-08 | |
PCT/US2009/005510 WO2010042189A2 (en) | 2008-10-08 | 2009-10-08 | Engineered cells expressing multiple immunomodulators and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0920679A2 true BRPI0920679A2 (pt) | 2022-05-17 |
Family
ID=42101134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0920679A BRPI0920679A2 (pt) | 2008-10-08 | 2009-10-08 | Células construídas expressando múltiplos imunomoduladores e usos das mesmas |
Country Status (12)
Country | Link |
---|---|
US (4) | US9492482B2 (pt) |
EP (1) | EP2356219A4 (pt) |
JP (3) | JP2012504959A (pt) |
KR (2) | KR101629071B1 (pt) |
CN (1) | CN102575227A (pt) |
AU (3) | AU2009302804B2 (pt) |
BR (1) | BRPI0920679A2 (pt) |
CA (1) | CA2739902A1 (pt) |
IL (3) | IL212184A (pt) |
MX (1) | MX340972B (pt) |
RU (1) | RU2573912C2 (pt) |
WO (1) | WO2010042189A2 (pt) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090136465A1 (en) | 2007-09-28 | 2009-05-28 | Intrexon Corporation | Therapeutic Gene-Switch Constructs and Bioreactors for the Expression of Biotherapeutic Molecules, and Uses Thereof |
JP2013527753A (ja) * | 2010-03-23 | 2013-07-04 | イントレキソン コーポレーション | 治療タンパク質を条件的に発現するベクター、該ベクターを含む宿主細胞およびそれらの使用 |
JP6189754B2 (ja) * | 2011-03-04 | 2017-08-30 | イントレキソン コーポレーション | タンパク質を条件的に発現するベクター |
BR112014005509B1 (pt) | 2011-09-08 | 2022-11-29 | Intrexon Corporation | Diacil-hidrazina cristalina e composição, uso, método para produzir e kit da mesma |
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US11951157B2 (en) | 2011-10-11 | 2024-04-09 | Universitat Zurich | Methods of treating malignant tumour with IL-12 and anti-PD-1 antibody |
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