ATE483815T1 - Expressionskonstrukte mit mehreren rna-polymerase-iii-promotoren - Google Patents
Expressionskonstrukte mit mehreren rna-polymerase-iii-promotorenInfo
- Publication number
- ATE483815T1 ATE483815T1 AT05810305T AT05810305T ATE483815T1 AT E483815 T1 ATE483815 T1 AT E483815T1 AT 05810305 T AT05810305 T AT 05810305T AT 05810305 T AT05810305 T AT 05810305T AT E483815 T1 ATE483815 T1 AT E483815T1
- Authority
- AT
- Austria
- Prior art keywords
- polymerase iii
- expression constructs
- iii promoters
- rna polymerase
- multiple rna
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60362204P | 2004-08-23 | 2004-08-23 | |
US62994204P | 2004-11-22 | 2004-11-22 | |
PCT/US2005/029976 WO2006033756A2 (en) | 2004-08-23 | 2005-08-23 | Multiple rna polymerase iii promoter expression constructs |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE483815T1 true ATE483815T1 (de) | 2010-10-15 |
Family
ID=36090440
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05810305T ATE483815T1 (de) | 2004-08-23 | 2005-08-23 | Expressionskonstrukte mit mehreren rna-polymerase-iii-promotoren |
Country Status (8)
Country | Link |
---|---|
US (2) | US7985581B2 (de) |
EP (3) | EP2169072A1 (de) |
JP (1) | JP4804467B2 (de) |
AT (1) | ATE483815T1 (de) |
AU (1) | AU2005287365B2 (de) |
CA (1) | CA2577519A1 (de) |
DE (1) | DE602005024015D1 (de) |
WO (1) | WO2006033756A2 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8575327B2 (en) | 2003-06-12 | 2013-11-05 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
JP4980716B2 (ja) * | 2003-06-12 | 2012-07-18 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 遺伝子サイレンシングに有用な保存されたhbv及びhcv配列 |
AU2016202897A1 (en) * | 2004-12-22 | 2016-05-19 | Alnylam Pharmaceuticals, Inc. | Conserved HBV and HCV sequences useful for gene silencing |
ATE507293T1 (de) * | 2004-12-22 | 2011-05-15 | Alnylam Pharmaceuticals Inc | Zum gen-silencing geeignete konservierte hbv- und hcv-sequenzen |
JP2008237023A (ja) * | 2005-07-15 | 2008-10-09 | Univ Of Tokyo | 多重shRNA発現ベクター |
WO2008147430A2 (en) * | 2006-10-11 | 2008-12-04 | Nucleonics, Inc. | Microrna-formatted multitarget interfering rna vector constructs and methods of using the same |
ES2434169T3 (es) | 2006-11-08 | 2013-12-13 | Veritas Bio, Llc | Entrega in vivo de ARN bicatenario a una célula objetivo |
WO2008148068A1 (en) * | 2007-05-23 | 2008-12-04 | Mannkind Corporation | Multicistronic vectors and methods for their design |
HUE044815T2 (hu) | 2010-08-17 | 2019-11-28 | Sirna Therapeutics Inc | Hepatitisz B vírus (HBV) génexpressziójának RNS-interferencia közvetített gátlása, rövid interferáló nukleinsav (SINS) alkalmazásával |
CA2839896A1 (en) | 2011-06-21 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Assays and methods for determining activity of a therapeutic agent in a subject |
WO2013036879A1 (en) * | 2011-09-08 | 2013-03-14 | Gradalis, Inc. | Compositions and methods for treating prostate cancer |
WO2013067050A1 (en) | 2011-10-31 | 2013-05-10 | University Of Utah Research Foundation | Genetic alterations in glioblastoma |
CN104394892B (zh) * | 2012-05-15 | 2020-02-14 | 北京命码生科科技有限公司 | 植物作为功能microRNA和/或功能siRNA运载体、制备方法及其应用 |
WO2015048690A1 (en) * | 2013-09-27 | 2015-04-02 | The Regents Of The University Of California | Optimized small guide rnas and methods of use |
US11141493B2 (en) | 2014-03-10 | 2021-10-12 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
US11339437B2 (en) * | 2014-03-10 | 2022-05-24 | Editas Medicine, Inc. | Compositions and methods for treating CEP290-associated disease |
DK3116997T3 (da) | 2014-03-10 | 2019-08-19 | Editas Medicine Inc | Crispr/cas-relaterede fremgangsmåder og sammensætninger til behandling af lebers kongenitale amaurose 10 (lca10) |
WO2016030863A1 (en) | 2014-08-29 | 2016-03-03 | Glaxosmithkline Intellectual Property Development Limited | Compounds and methods for treating viral infections |
US20180291382A1 (en) * | 2014-11-05 | 2018-10-11 | The Regents Of The University Of California | Methods for Autocatalytic Genome Editing and Neutralizing Autocatalytic Genome Editing |
JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
WO2016141243A1 (en) * | 2015-03-03 | 2016-09-09 | The Regents Of The University Of California | Enzymatic modification of nucleic acids |
TWI554608B (zh) * | 2015-03-27 | 2016-10-21 | Univ China Medical | A nucleic acid sequence segment for enhancing protein expression, an expression vector comprising a sequence segment thereof, and a kit comprising its expression vector |
WO2017177029A1 (en) * | 2016-04-06 | 2017-10-12 | Duke University | Compositions and methods for enhanced gene expression and viral replication |
AU2017305404B2 (en) | 2016-08-02 | 2023-11-30 | Editas Medicine, Inc. | Compositions and methods for treating CEP290 associated disease |
EP3496727A4 (de) * | 2016-08-12 | 2020-03-18 | The Regents of the University of California | Konstrukte und verfahren zur signalverstärkung |
EP4035659A1 (de) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosome zur ausgabe von therapeutischen wirkstoffen |
US11324820B2 (en) | 2017-04-18 | 2022-05-10 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis b virus (HBV) infection |
DK3768846T3 (da) * | 2018-03-21 | 2023-07-24 | Aldevron L L C | Virale og ikke-virale nanoplasmidvektorer med forbedret produktion |
AR114551A1 (es) | 2018-08-13 | 2020-09-16 | Alnylam Pharmaceuticals Inc | COMPOSICIONES DE AGENTES DE ARNhd CONTRA EL VIRUS DE HEPATITIS B (HBV) Y MÉTODOS PARA SU USO |
WO2020160121A1 (en) * | 2019-01-29 | 2020-08-06 | The General Hospital Corporation | Oligonucleotides and methods for the treatment of age-related macular degeneration |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
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US5643771A (en) | 1980-05-19 | 1997-07-01 | The Board Of Trustees Of The Leland Stanford Junior University | Non-reverting live bacterial vaccines |
US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5279833A (en) | 1990-04-04 | 1994-01-18 | Yale University | Liposomal transfection of nucleic acids into animal cells |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US5283185A (en) | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
US5547862A (en) | 1993-07-29 | 1996-08-20 | Ambion Inc. | Vectors containing multiple promoters in the same orientation |
US5624803A (en) | 1993-10-14 | 1997-04-29 | The Regents Of The University Of California | In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides derived therefrom |
EP0728202A4 (de) | 1993-11-12 | 1997-04-23 | Univ Case Western Reserve | Episomales expressionsvektor für die menschliche gentherapy |
US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
US5585263A (en) | 1994-05-20 | 1996-12-17 | University Of Alabama At Birmingham Research Foundation | Purified retroviral constitutive transport enhancer and its use to facilitate mRNA transport, and to produce recombinant, attenuated HIV |
US5837533A (en) | 1994-09-28 | 1998-11-17 | American Home Products Corporation | Complexes comprising a nucleic acid bound to a cationic polyamine having an endosome disruption agent |
US5877159A (en) | 1995-05-03 | 1999-03-02 | University Of Maryland At Baltimore | Method for introducing and expressing genes in animal cells and live invasive bacterial vectors for use in the same |
US5932241A (en) | 1995-06-07 | 1999-08-03 | Valentis, Incorporated | Cationic lipid DNA complexes for gene targeting |
US5824538A (en) | 1995-09-06 | 1998-10-20 | The United States Of America As Represented By The Secretary Of The Army | Shigella vector for delivering DNA to a mammalian cell |
AU7450496A (en) | 1995-10-20 | 1997-05-07 | Collagen Corporation | Production of recombinant procollagen in yeast |
US5851804A (en) | 1996-05-06 | 1998-12-22 | Apollon, Inc. | Chimeric kanamycin resistance gene |
DE69738514D1 (de) * | 1996-11-08 | 2008-03-27 | Neose Technologies Inc | Verbesserte expressionsvektoren |
US5874242A (en) * | 1997-03-19 | 1999-02-23 | University Of Georgia Research Foundation, Inc. | Efficient translation in eukaryotic and prokaryotic systems |
CA2306733A1 (en) | 1997-10-28 | 1999-05-06 | American Home Products Corporation | Compositions and methods for delivery of genetic material |
US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
CA2323179A1 (en) | 1998-03-16 | 1999-09-23 | The Procter & Gamble Company | Method of reducing cellulite in mammalian skin |
KR20070118315A (ko) | 1999-04-21 | 2007-12-14 | 와이어쓰 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물 |
US20020132257A1 (en) | 2001-01-31 | 2002-09-19 | Tony Giordano | Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell |
JP2003269028A (ja) | 2002-03-18 | 2003-09-25 | Aisin Seiki Co Ltd | ドアロック解除装置 |
JP4868739B2 (ja) | 2002-05-06 | 2012-02-01 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 核酸の送達法 |
WO2004011624A2 (en) | 2002-07-31 | 2004-02-05 | Nucleonics, Inc. | Double stranded rna structures and constructs, and methods for generating and using the same |
US7303906B2 (en) | 2002-09-06 | 2007-12-04 | Wisconsin Alumni Research Foundation | Competent bacteria |
AU2003284323A1 (en) | 2002-10-18 | 2004-05-04 | Alnylam Pharmaceuticals Inc | Double-stranded rna structures and constructs, and methods for generating and using the same |
AU2004214954A1 (en) | 2003-02-27 | 2004-09-10 | Alnylam Pharmaceuticals, Inc. | Methods and constructs for evaluation of RNAi targets and effector molecules |
JP4980716B2 (ja) | 2003-06-12 | 2012-07-18 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 遺伝子サイレンシングに有用な保存されたhbv及びhcv配列 |
US20050130184A1 (en) | 2003-07-18 | 2005-06-16 | University Of Massachusetts | Enhanced promoters for synthesis of small hairpin RNA |
US20050130919A1 (en) | 2003-07-18 | 2005-06-16 | University Of Massachusetts | Regulatable promoters for synthesis of small hairpin RNA |
CA2536026A1 (en) | 2003-08-22 | 2005-05-06 | Nucleonics Inc. | Eukariotic expression systems for expression of inhibitory rna in multiple intracellular compartments |
US20060171924A1 (en) | 2003-10-03 | 2006-08-03 | Ke Luo | Bidirectional promoters for small RNA expression |
WO2005111219A1 (en) | 2004-04-16 | 2005-11-24 | University Of Washington | METHODS AND VECTORS FOR EXPRESSING siRNA |
-
2005
- 2005-08-23 EP EP09015841A patent/EP2169072A1/de not_active Withdrawn
- 2005-08-23 EP EP05810305A patent/EP1784492B1/de active Active
- 2005-08-23 AU AU2005287365A patent/AU2005287365B2/en active Active
- 2005-08-23 AT AT05810305T patent/ATE483815T1/de not_active IP Right Cessation
- 2005-08-23 WO PCT/US2005/029976 patent/WO2006033756A2/en active Search and Examination
- 2005-08-23 EP EP10011039A patent/EP2270161A3/de not_active Withdrawn
- 2005-08-23 CA CA002577519A patent/CA2577519A1/en not_active Abandoned
- 2005-08-23 DE DE602005024015T patent/DE602005024015D1/de active Active
- 2005-08-23 US US11/660,937 patent/US7985581B2/en active Active
- 2005-08-23 JP JP2007530052A patent/JP4804467B2/ja active Active
-
2011
- 2011-06-15 US US13/160,774 patent/US20120028348A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4804467B2 (ja) | 2011-11-02 |
DE602005024015D1 (de) | 2010-11-18 |
EP1784492A2 (de) | 2007-05-16 |
EP2270161A2 (de) | 2011-01-05 |
EP2169072A1 (de) | 2010-03-31 |
EP1784492B1 (de) | 2010-10-06 |
CA2577519A1 (en) | 2006-03-30 |
US7985581B2 (en) | 2011-07-26 |
US20090298909A1 (en) | 2009-12-03 |
US20120028348A1 (en) | 2012-02-02 |
WO2006033756A3 (en) | 2007-01-18 |
JP2008510489A (ja) | 2008-04-10 |
AU2005287365B2 (en) | 2011-02-10 |
AU2005287365A1 (en) | 2006-03-30 |
WO2006033756A2 (en) | 2006-03-30 |
EP2270161A3 (de) | 2011-02-02 |
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