TWI394582B - 抗體調配物 - Google Patents
抗體調配物 Download PDFInfo
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- TWI394582B TWI394582B TW094136752A TW94136752A TWI394582B TW I394582 B TWI394582 B TW I394582B TW 094136752 A TW094136752 A TW 094136752A TW 94136752 A TW94136752 A TW 94136752A TW I394582 B TWI394582 B TW I394582B
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Cited By (1)
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| TWI835773B (zh) * | 2018-01-26 | 2024-03-21 | 美商建南德克公司 | 組合物及使用方法 |
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| US20040013667A1 (en) * | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| US20030228309A1 (en) * | 2000-11-08 | 2003-12-11 | Theodora Salcedo | Antibodies that immunospecifically bind to TRAIL receptors |
| US20060062786A1 (en) * | 2000-11-08 | 2006-03-23 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| JP4414142B2 (ja) | 2001-05-11 | 2010-02-10 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 特異的結合タンパク質およびその使用 |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| US20050129616A1 (en) * | 2001-05-25 | 2005-06-16 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US20050214209A1 (en) * | 2001-05-25 | 2005-09-29 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to TRAIL receptors |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
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| CN1610696A (zh) * | 2001-12-20 | 2005-04-27 | 人体基因组科学有限公司 | 免疫特异性结合trail受体的抗体 |
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| DK1776136T3 (da) | 2004-06-24 | 2012-12-03 | Biogen Idec Inc | Behandling af tilstande, der involverer demyelinisering |
| KR20190126461A (ko) | 2004-07-22 | 2019-11-11 | 제넨테크, 인크. | Her2 항체 조성물 |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CN101115849A (zh) * | 2004-12-07 | 2008-01-30 | 健泰科生物技术公司 | 选择her抑制剂疗法的患者 |
| KR20200058588A (ko) | 2005-01-21 | 2020-05-27 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
| US8029783B2 (en) * | 2005-02-02 | 2011-10-04 | Genentech, Inc. | DR5 antibodies and articles of manufacture containing same |
| MY152164A (en) * | 2005-02-23 | 2014-08-15 | Genentech Inc | Extending time to disease progression or survival in cancer patients |
| NZ560844A (en) | 2005-03-08 | 2008-08-29 | Pharmacia & Upjohn Co Llc | Anti-MAdCAM antibody compositions |
| BRPI0613387A2 (pt) | 2005-07-08 | 2011-01-11 | Biogen Idec Inc | anticorpo isolado ou fragmento de ligação de antìgeno deste e o seu uso, polinucleotìdeo isolado, composição, vetor, célula hospedeira, anticorpo anti-sp35 e método para a produção do mesmo, polipeptìdeo isolado, método in vitro para redução da inibição do crescimento axonal e método in vitro para inibição do crescimento do colapso do cone |
| PE20070207A1 (es) * | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| WO2007024743A2 (en) * | 2005-08-19 | 2007-03-01 | Centocor, Inc. | Proteolysis resistant antibody preparations |
| US20070212397A1 (en) * | 2005-09-15 | 2007-09-13 | Roth Daniel B | Pharmaceutical delivery device and method for providing ocular treatment |
| EP1965827B1 (en) | 2005-12-02 | 2015-02-25 | Biogen Idec MA Inc. | Treatment of conditions involving demyelination |
| ES2439641T3 (es) | 2005-12-20 | 2014-01-24 | Bristol-Myers Squibb Company | Composiciones y procedimientos de producción de una composición |
| PE20071063A1 (es) | 2005-12-20 | 2007-10-24 | Bristol Myers Squibb Co | Formulaciones de proteinas estables |
| AR058568A1 (es) | 2005-12-20 | 2008-02-13 | Bristol Myers Squibb Co | Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo |
| US9309316B2 (en) | 2005-12-20 | 2016-04-12 | Bristol-Myers Squibb Company | Stable subcutaneous protein formulations and uses thereof |
| CA2654369C (en) | 2006-06-21 | 2014-10-14 | Ge Healthcare Limited | Radiopharmaceutical products |
| AU2013202392B2 (en) * | 2006-12-20 | 2016-02-25 | Mmrglobal, Inc. | Antibodies and methods for making and using them |
| CN101675074B (zh) | 2006-12-20 | 2016-02-24 | Mmr全球公司 | 抗体及其制备和使用方法 |
| US8128926B2 (en) | 2007-01-09 | 2012-03-06 | Biogen Idec Ma Inc. | Sp35 antibodies and uses thereof |
| CN104013956B (zh) | 2007-01-25 | 2018-12-18 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| KR20150039212A (ko) | 2007-03-02 | 2015-04-09 | 제넨테크, 인크. | 낮은 her3 발현을 기초로 한 her 이량체화 억제제에 대한 반응 예측 |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| NZ598881A (en) * | 2007-03-29 | 2013-11-29 | Abbvie Inc | Crystalline anti-human il-12 antibodies |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| CL2008002886A1 (es) | 2007-09-26 | 2009-12-04 | Chugai Pharmaceutical Co Ltd | Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende. |
| CA2701189C (en) * | 2007-10-11 | 2017-05-16 | Biogen Idec Ma Inc. | Methods for treating pressure induced optic neuropathy, preventing neuronal degeneration and promoting neuronal cell survival via administration of lingo-1 antagonists and trkb agonists |
| AU2008325107B2 (en) * | 2007-11-08 | 2015-04-23 | Biogen Ma Inc. | Use of LINGO-4 antagonists in the treatment of conditions involving demyelination |
| US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
| US20090162359A1 (en) | 2007-12-21 | 2009-06-25 | Christian Klein | Bivalent, bispecific antibodies |
| DK2234600T3 (da) * | 2007-12-21 | 2014-09-08 | Hoffmann La Roche | Antistofformulering |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| UA100255C2 (uk) * | 2007-12-28 | 2012-12-10 | Біоінвент Інтернешенл Аб | Фармацевтична композиція |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
| CA2725390C (en) * | 2008-04-08 | 2014-09-23 | Syndax Pharmaceuticals, Inc. | Use of a hdac inhibitor and a her-2 inhibitor in the treatment of breast cancer |
| CA2722466A1 (en) | 2008-04-29 | 2009-11-05 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| EP2297208A4 (en) | 2008-06-03 | 2012-07-11 | Abbott Lab | DUAL VARIABLE DOMAIN IMMUNOGLOBULINS AND ITS USES |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| KR20110031369A (ko) | 2008-07-08 | 2011-03-25 | 아보트 러보러터리즈 | 프로스타글란딘 e2 이원 가변 도메인 면역글로불린 및 이의 용도 |
| US8058406B2 (en) * | 2008-07-09 | 2011-11-15 | Biogen Idec Ma Inc. | Composition comprising antibodies to LINGO or fragments thereof |
| TW201438738A (zh) | 2008-09-16 | 2014-10-16 | 建南德克公司 | 治療進展型多發性硬化症之方法 |
| JP5642683B2 (ja) * | 2008-09-19 | 2014-12-17 | ファイザー・インク | 安定な液体抗体配合物 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| US8268314B2 (en) | 2008-10-08 | 2012-09-18 | Hoffmann-La Roche Inc. | Bispecific anti-VEGF/anti-ANG-2 antibodies |
| CN102438652B (zh) * | 2008-11-12 | 2014-08-13 | 米迪缪尼有限公司 | 抗体制剂 |
| KR101676887B1 (ko) * | 2008-11-20 | 2016-11-16 | 제넨테크, 인크. | 치료 단백질 제형 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| WO2010075249A2 (en) | 2008-12-22 | 2010-07-01 | Genentech, Inc. | A method for treating rheumatoid arthritis with b-cell antagonists |
| FR2944448B1 (fr) | 2008-12-23 | 2012-01-13 | Adocia | Composition pharmaceutique stable comprenant au moins un anticorps monodonal et au moins un polysacharide amphiphile comprenant des substituants derives d'alcools hydrofobes ou d'amines hydrophobes. |
| PL2391419T3 (pl) | 2009-01-29 | 2019-12-31 | Forsight Vision4, Inc. | Dostarczanie leku do tylnego odcinka |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| EP2403873A1 (en) | 2009-03-05 | 2012-01-11 | Ablynx N.V. | Novel antigen binding dimer-complexes, methods of making/avoiding and uses thereof |
| US9265834B2 (en) | 2009-03-05 | 2016-02-23 | Ablynx N.V. | Stable formulations of polypeptides and uses thereof |
| SG174258A1 (en) * | 2009-03-06 | 2011-10-28 | Genentech Inc | Antibody formulation |
| WO2010106812A1 (en) * | 2009-03-19 | 2010-09-23 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical formulation containing improved antibody molecules |
| CA2756244A1 (en) | 2009-04-02 | 2010-10-07 | Roche Glycart Ag | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| ES2537100T3 (es) | 2009-04-07 | 2015-06-02 | Roche Glycart Ag | Anticuerpos biespecíficos trivalentes |
| WO2010129469A1 (en) * | 2009-05-04 | 2010-11-11 | Abbott Biotechnology Ltd. | Stable high protein concentration formulations of human anti-tnf-alpha-antibodies |
| WO2010146059A2 (en) | 2009-06-16 | 2010-12-23 | F. Hoffmann-La Roche Ag | Biomarkers for igf-1r inhibitor therapy |
| US9676845B2 (en) | 2009-06-16 | 2017-06-13 | Hoffmann-La Roche, Inc. | Bispecific antigen binding proteins |
| WO2010148223A2 (en) * | 2009-06-17 | 2010-12-23 | Facet Biotech Corporation | Anti-vegf antibodies and their uses |
| US8703132B2 (en) * | 2009-06-18 | 2014-04-22 | Hoffmann-La Roche, Inc. | Bispecific, tetravalent antigen binding proteins |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| AU2013202020B2 (en) * | 2009-07-31 | 2014-11-27 | F. Hoffmann-La Roche Ag | Subcutaneous anti-HER2 antibody formulation |
| US8221753B2 (en) | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
| FI3725330T3 (fi) * | 2009-09-03 | 2025-11-14 | Ablynx Nv | Polypeptidien stabiilit valmisteet ja niiden käyttötarkoitukset |
| WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
| AR078161A1 (es) * | 2009-09-11 | 2011-10-19 | Hoffmann La Roche | Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento. |
| AU2010296018B2 (en) | 2009-09-16 | 2016-05-05 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| US8937159B2 (en) * | 2009-12-16 | 2015-01-20 | Abbvie Biotherapeutics Inc. | Anti-HER2 antibodies and their uses |
| CN102770158B (zh) * | 2009-12-21 | 2016-10-19 | 霍夫曼-拉罗奇有限公司 | 抗体配制剂 |
| FR2958646B1 (fr) | 2010-04-07 | 2012-05-18 | Adocia | Polysaccharides comportant des groupes fonctionnels carboxyles substitues par un derive d'acide hydrophobe. |
| AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
| US9120855B2 (en) | 2010-02-10 | 2015-09-01 | Novartis Ag | Biologic compounds directed against death receptor 5 |
| ES2519348T3 (es) | 2010-02-18 | 2014-11-06 | Genentech, Inc. | Antagonistas de neurregulina y uso de los mismos en el tratamiento del cáncer |
| DK3345615T3 (da) | 2010-03-01 | 2020-01-20 | Bayer Healthcare Llc | Optimerede monoklonale antistoffer mod inhibitor af vævsfaktoraktiveringsvejen (tfpi) |
| MX354867B (es) * | 2010-03-22 | 2018-03-23 | Genentech Inc Star | Composiciones y métodos útiles para estabilizar formulaciones que contienen proteína. |
| EP2550295A1 (en) | 2010-03-24 | 2013-01-30 | F. Hoffmann-La Roche AG | Anti-lrp6 antibodies |
| AR080793A1 (es) | 2010-03-26 | 2012-05-09 | Roche Glycart Ag | Anticuerpos biespecificos |
| WO2011147834A1 (en) | 2010-05-26 | 2011-12-01 | Roche Glycart Ag | Antibodies against cd19 and uses thereof |
| NZ604003A (en) | 2010-05-27 | 2015-04-24 | Genmab As | Monoclonal antibodies against her2 |
| TW201204388A (en) | 2010-06-18 | 2012-02-01 | Genentech Inc | Anti-Axl antibodies and methods of use |
| WO2011161119A1 (en) | 2010-06-22 | 2011-12-29 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof |
| WO2011161189A1 (en) | 2010-06-24 | 2011-12-29 | F. Hoffmann-La Roche Ag | Anti-hepsin antibodies and methods of use |
| CA2802756C (en) * | 2010-06-24 | 2021-05-04 | Genentech, Inc. | Compositions and methods for stabilizing protein-containing formulations |
| EP2399604A1 (en) * | 2010-06-25 | 2011-12-28 | F. Hoffmann-La Roche AG | Novel antibody formulation |
| JOP20190250A1 (ar) * | 2010-07-14 | 2017-06-16 | Regeneron Pharma | صيغ مستقرة تحتوي على الأجسام المضادة لمضاد عامل نمو الأعصاب |
| WO2012007495A1 (en) | 2010-07-15 | 2012-01-19 | F. Hoffmann-La Roche Ag | Antibodies specifically binding to human tslpr and methods of use |
| WO2012010582A1 (en) | 2010-07-21 | 2012-01-26 | Roche Glycart Ag | Anti-cxcr5 antibodies and methods of use |
| EP2601218A4 (en) | 2010-08-03 | 2015-02-18 | Abbvie Inc | VARIABLE DOUBLE DOMAIN IMMUNOGLOBULINS AND USES THEREOF |
| EP2600812B1 (en) | 2010-08-05 | 2021-09-22 | ForSight Vision4, Inc. | Apparatus to treat an eye |
| US9033911B2 (en) | 2010-08-05 | 2015-05-19 | Forsight Vision4, Inc. | Injector apparatus and method for drug delivery |
| BR112013002532A2 (pt) | 2010-08-05 | 2016-05-31 | Hoffmann La Roche | proteína de fusão de citocina anti-viral do anticorpo anti-mhc |
| EP2600876B1 (en) | 2010-08-05 | 2015-04-29 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
| RU2584597C2 (ru) | 2010-08-13 | 2016-05-20 | Рош Гликарт Аг | Антитела против а2 тенасцина с и способы их применения |
| RU2013110844A (ru) | 2010-08-13 | 2014-09-20 | Дженентек, Инк. | АНТИТЕЛА ПРОТИВ IL-1β И IL-18, ИСПОЛЬЗУЕМЫЕ ДЛЯ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЙ |
| HUE036077T2 (hu) | 2010-08-13 | 2018-06-28 | Roche Glycart Ag | Anti-FAP ellenanyagok és alkalmazásukra szolgáló eljárások |
| EP2609111B1 (en) | 2010-08-24 | 2017-11-01 | F. Hoffmann-La Roche AG | Bispecific antibodies comprising a disulfide stabilized-fv fragment |
| WO2012025536A1 (en) | 2010-08-25 | 2012-03-01 | F. Hoffmann-La Roche Ag | Antibodies against il-18r1 and uses thereof |
| BR112013004581A2 (pt) | 2010-08-26 | 2017-06-27 | Abbvie Inc | imunoglobulinas de domínio variável dual e seus usos |
| EA027353B1 (ru) | 2010-09-17 | 2017-07-31 | Баксалта Инкорпорейтид | СТАБИЛИЗАЦИЯ ИММУНОГЛОБУЛИНОВ С ПОМОЩЬЮ ВОДНОГО СОСТАВА С ГИСТИДИНОМ ПРИ pH ОТ СЛАБОКИСЛОГО ДО НЕЙТРАЛЬНОГО |
| JP2013543384A (ja) | 2010-10-05 | 2013-12-05 | ノバルティス アーゲー | 抗−il12rベータ1抗体ならびに自己免疫性および炎症性疾患の処置おけるその使用 |
| CN106267189B (zh) * | 2010-10-06 | 2021-02-26 | 瑞泽恩制药公司 | 含有抗白介素-4受体(il-4r)的抗体的稳定制剂 |
| PT2635601T (pt) | 2010-11-04 | 2016-09-27 | Boehringer Ingelheim Int | Anticorpos anti-il-23 |
| TW201300417A (zh) | 2010-11-10 | 2013-01-01 | Genentech Inc | 用於神經疾病免疫療法之方法及組合物 |
| HRP20161753T1 (hr) | 2010-11-11 | 2017-02-10 | Abbvie Biotechnology Ltd | Tekuće formulacije protutijela anti-tnf-alfa s visokom koncentracijom |
| WO2012068549A2 (en) | 2010-11-19 | 2012-05-24 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| WO2012076670A2 (en) * | 2010-12-10 | 2012-06-14 | Novartis Ag | Antibody formulation |
| RU2737245C2 (ru) | 2010-12-16 | 2020-11-26 | Дженентек, Инк. | Способы диагностики и лечения, связанные с ингибированием тн2 |
| EP3296321B1 (en) | 2010-12-20 | 2020-07-15 | F. Hoffmann-La Roche AG | Anti-mesothelin antibodies and immunoconjugates |
| EA201390929A1 (ru) | 2010-12-22 | 2013-12-30 | Дженентек, Инк. | Антитела к pcsk9 и способы их применения |
| WO2012085111A1 (en) | 2010-12-23 | 2012-06-28 | F. Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| EP2471554A1 (en) * | 2010-12-28 | 2012-07-04 | Hexal AG | Pharmaceutical formulation comprising a biopharmaceutical drug |
| CA2822481A1 (en) | 2011-01-03 | 2012-07-12 | F. Hoffmann-La Roche Ag | A pharmaceutical composition of a complex of an anti-dig antibody and digoxigenin that is conjugated to a peptide |
| MX366458B (es) | 2011-01-28 | 2019-07-10 | Sanofi Biotechnology | Composiciones farmaceuticas que comprenden anticuerpos humanos frente a pcsk9. |
| MX2013009151A (es) | 2011-02-10 | 2013-08-29 | Roche Glycart Ag | Inmunoterapia mejorada. |
| CA2824824A1 (en) | 2011-02-28 | 2012-09-07 | F. Hoffmann-La Roche Ag | Monovalent antigen binding proteins |
| BR112013019975A2 (pt) | 2011-02-28 | 2017-08-01 | Hoffmann La Roche | proteínas de ligação de antígeno, composição farmacêutica, uso de uma proteína de ligação de antígeno, método para o tratamento de um paciente e método para a preparação de uma proteína de ligação de antígeno, ácido nucleico, vetor e célula hospedeira" |
| KR20160044598A (ko) | 2011-03-29 | 2016-04-25 | 로슈 글리카트 아게 | 항체 Fc 변이체 |
| RU2563346C2 (ru) | 2011-03-31 | 2015-09-20 | Мерк Шарп И Доум Корп. | Стабильные составы антител против рецептора программируемой смерти pd-1 человека и относящиеся к ним способы лечения |
| WO2012138975A1 (en) | 2011-04-07 | 2012-10-11 | Genentech, Inc. | Anti-fgfr4 antibodies and methods of use |
| US20140170148A1 (en) * | 2011-04-20 | 2014-06-19 | Genmab A/S | Bispecific antibodies against her2 |
| MX2013012071A (es) | 2011-04-20 | 2014-01-20 | Roche Glycart Ag | Metodo y constructos para el pasaje dependiente del ph de la barrera hematoencefalica. |
| AU2012245116A1 (en) | 2011-04-20 | 2013-11-07 | Genmab A/S | Bispecific antibodies against HER2 and CD3 |
| WO2012146630A1 (en) | 2011-04-29 | 2012-11-01 | F. Hoffmann-La Roche Ag | N-terminal acylated polypeptides, methods for their production and uses thereof |
| US10040855B2 (en) * | 2011-05-02 | 2018-08-07 | Millennium Pharmaceuticals, Inc. | Formulation for anti-α4β7 antibody |
| LT2710035T (lt) | 2011-05-16 | 2017-06-26 | F. Hoffmann-La Roche Ag | Fgfr1 agonistai ir jų naudojimo būdai |
| KR101629073B1 (ko) | 2011-06-15 | 2016-06-09 | 에프. 호프만-라 로슈 아게 | 항-인간 에리스로포이에틴 수용체 항체 및 이의 사용 방법 |
| ES2667864T3 (es) | 2011-06-22 | 2018-05-14 | F. Hoffmann-La Roche Ag | Eliminación de células diana mediante linfocitos T citotóxicos específicos de virus en circulación usando complejos que comprenden MHC de clase I |
| EP2726016B1 (en) | 2011-06-28 | 2023-07-19 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
| RU2013155695A (ru) | 2011-06-30 | 2015-08-10 | Дженентек, Инк. | Препараты антител против с-мет |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE |
| WO2013025853A1 (en) | 2011-08-17 | 2013-02-21 | Genentech, Inc. | Neuregulin antibodies and uses thereof |
| KR101723273B1 (ko) | 2011-08-23 | 2017-04-04 | 로슈 글리카트 아게 | 2 개의 fab 단편을 포함하는 fc-부재 항체 및 이용 방법 |
| KR20140048292A (ko) | 2011-08-23 | 2014-04-23 | 로슈 글리카트 아게 | 항-mcsp 항체 |
| US20130058936A1 (en) | 2011-08-23 | 2013-03-07 | Peter Bruenker | Bispecific antibodies specific for t-cell activating antigens and a tumor antigen and methods of use |
| CA2845179A1 (en) | 2011-08-31 | 2013-03-07 | Genentech, Inc. | Diagnostic markers |
| EP2756300A1 (en) | 2011-09-15 | 2014-07-23 | F.Hoffmann-La Roche Ag | Methods of promoting differentiation |
| EP2755600B1 (en) | 2011-09-16 | 2021-03-17 | ForSight Vision4, Inc. | Fluid exchange apparatus |
| HK1200850A1 (en) | 2011-09-23 | 2015-08-14 | 罗氏格黎卡特股份公司 | Bispecific anti-egfr/anti igf-1r antibodies |
| KR102102862B1 (ko) | 2011-10-14 | 2020-04-22 | 제넨테크, 인크. | 항-HtrA1 항체 및 사용 방법 |
| BR112014007521A8 (pt) | 2011-10-14 | 2018-04-10 | Genentech Inc | método para estender a sobrevida livre de progressão em uma população com câncer de mama, artigo de fabricação, método para produção de um artigo de fabricação, para garantir o uso seguro e efetivo de pertuzumabe, de tratar câncer de mama, bolsa intravenosa, método de tratar câncer gástrico, de tratar adenocarcinoma do estômago e de melhora de sobrevida |
| JP6254087B2 (ja) | 2011-10-15 | 2017-12-27 | ジェネンテック, インコーポレイテッド | 癌を治療するためのscd1アンタゴニスト |
| WO2013059531A1 (en) | 2011-10-20 | 2013-04-25 | Genentech, Inc. | Anti-gcgr antibodies and uses thereof |
| IN2014CN03555A (enExample) | 2011-10-25 | 2015-07-03 | Onclave Therapeutics Ltd | |
| BR112014009953A2 (pt) | 2011-10-28 | 2017-12-05 | Genentech Inc | método de inibição do crescimento de tumores, de tratamento de melanoma, artigo industrializado e uso |
| EP3378535B1 (en) | 2011-10-28 | 2023-01-04 | Prothena Biosciences Limited | Humanized antibodies that recognize alpha-synuclein |
| EP2773662A4 (en) * | 2011-10-31 | 2015-07-01 | Hoffmann La Roche | ANTIBODY FORMULATIONS |
| US20130129718A1 (en) | 2011-11-21 | 2013-05-23 | Genentech, Inc. | Purification of anti-c-met antibodies |
| DE102011056142A1 (de) * | 2011-12-07 | 2013-06-13 | Manfred Rüdinger | Metabolisierbare Salze und deren Verwendung in Diagnostik und Therapie |
| JP2015508994A (ja) | 2011-12-30 | 2015-03-26 | アッヴィ・インコーポレイテッド | Il−13および/またはil−17に対する二重可変ドメイン免疫グロブリン |
| SG10201601747XA (en) | 2012-01-18 | 2016-04-28 | Genentech Inc | Anti-LRP5 Antibodies And Methods Of Use |
| CA2862424A1 (en) | 2012-01-18 | 2013-07-25 | Genentech, Inc. | Methods of using fgf19 modulators |
| AU2013212587B2 (en) * | 2012-01-23 | 2017-07-20 | Regeneron Pharmaceuticals, Inc. | Stabilized formulations containing anti-Ang2 antibodies |
| KR102086061B1 (ko) | 2012-01-27 | 2020-03-11 | 프로테나 바이오사이언시즈 리미티드 | 알파-시누클레인을 인식하는 인간화된 항체 |
| US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
| EP2812357B1 (en) | 2012-02-10 | 2020-11-04 | F.Hoffmann-La Roche Ag | Single-chain antibodies and other heteromultimers |
| BR112014019741A2 (pt) | 2012-02-11 | 2020-12-22 | Genentech, Inc | Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado |
| CN104125852B9 (zh) | 2012-02-15 | 2017-05-17 | 弗·哈夫曼-拉罗切有限公司 | 基于Fc‑受体的亲和色谱 |
| AR090244A1 (es) * | 2012-03-08 | 2014-10-29 | Hoffmann La Roche | Formulacion de anticuerpo anti-selectina p |
| JP6265970B2 (ja) * | 2012-03-26 | 2018-01-24 | サノフイ | 安定なIgG4に基づく結合剤の製剤 |
| US9592289B2 (en) | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
| AR090549A1 (es) | 2012-03-30 | 2014-11-19 | Genentech Inc | Anticuerpos anti-lgr5 e inmunoconjugados |
| EP2834273B1 (en) | 2012-04-05 | 2018-08-22 | F.Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
| US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
| SG11201407106XA (en) | 2012-05-01 | 2014-11-27 | Genentech Inc | Anti-pmel17 antibodies and immunoconjugates |
| EP4039275A1 (en) | 2012-05-03 | 2022-08-10 | Boehringer Ingelheim International GmbH | Anti-il-23p19 antibodies |
| US20140004131A1 (en) * | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| WO2013170191A1 (en) | 2012-05-11 | 2013-11-14 | Genentech, Inc. | Methods of using antagonists of nad biosynthesis from nicotinamide |
| JP2015518829A (ja) | 2012-05-14 | 2015-07-06 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 運動ニューロンに関する状態の処置のためのlingo−2アンタゴニスト |
| NZ701915A (en) | 2012-05-18 | 2016-11-25 | Genentech Inc | High-concentration monoclonal antibody formulations |
| AR092325A1 (es) | 2012-05-31 | 2015-04-15 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-dll4 y kit |
| US20130323242A1 (en) * | 2012-06-01 | 2013-12-05 | Ophthotech Corp. | Compositions comprising an anti-pdgf aptamer and a vegf antagonist |
| US9216219B2 (en) | 2012-06-12 | 2015-12-22 | Novartis Ag | Anti-BAFFR antibody formulation |
| CA2875096A1 (en) | 2012-06-15 | 2013-12-19 | Genentech, Inc. | Anti-pcsk9 antibodies, formulations, dosing, and methods of use |
| CN104582736A (zh) | 2012-06-21 | 2015-04-29 | 印第安纳大学研究及科技有限公司 | Fc效应子功能改变的肠降血糖素受体配体多肽Fc区融合多肽和缀合物 |
| JP6309002B2 (ja) | 2012-06-27 | 2018-04-11 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 標的に特異的に結合する少なくとも1つの結合実体を含む抗体Fc領域結合体を作製するための方法およびその使用 |
| BR112014029888A2 (pt) | 2012-06-27 | 2020-05-12 | Hoffmann La Roche | Métodos de produção de um anticorpo, de determinação de uma combinação de sítios de ligação e de tratamento de um indivíduo com câncer, formulação farmacêutica, anticorpo e uso de um anticorpo |
| EP2867253B1 (en) | 2012-06-27 | 2016-09-14 | F. Hoffmann-La Roche AG | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
| CN107973856B (zh) | 2012-07-04 | 2021-11-23 | 弗·哈夫曼-拉罗切有限公司 | 共价连接的抗原-抗体缀合物 |
| MX353951B (es) | 2012-07-04 | 2018-02-07 | Hoffmann La Roche | Anticuerpos de anti-teofilina y metodos de uso. |
| MX354303B (es) | 2012-07-04 | 2018-02-23 | Hoffmann La Roche | Anticuerpos de anti-biotina y metodos de uso. |
| HK1207972A1 (en) | 2012-07-09 | 2016-02-19 | 基因泰克公司 | Immunoconjugates comprising anti - cd79b antibodies |
| JP2015523380A (ja) | 2012-07-09 | 2015-08-13 | ジェネンテック, インコーポレイテッド | 抗cd79b抗体を含む免疫複合体 |
| TW201408696A (zh) | 2012-07-09 | 2014-03-01 | Genentech Inc | 抗cd22抗體及免疫結合物 |
| TW201406785A (zh) | 2012-07-09 | 2014-02-16 | Genentech Inc | 抗cd22抗體及免疫結合物 |
| UA120029C2 (uk) | 2012-07-13 | 2019-09-25 | Рош Глікарт Аг | Спосіб зниження в'язкості біспецифічного антитіла до vegf/ang-2 та застосування такого антитіла для лікування судинних очних захворювань |
| MX2015000681A (es) | 2012-08-02 | 2015-04-10 | Hoffmann La Roche | Metodo para producir receptores de fc (fcr) solubles como fusion de fc con region de fc de inmunoglobulina inerte y uso de las mismas. |
| AR092044A1 (es) | 2012-08-07 | 2015-03-18 | Roche Glycart Ag | Inmunoterapia mejorada |
| FR2994390B1 (fr) | 2012-08-10 | 2014-08-15 | Adocia | Procede d'abaissement de la viscosite de solutions de proteines a concentration elevee |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| US9592297B2 (en) | 2012-08-31 | 2017-03-14 | Bayer Healthcare Llc | Antibody and protein formulations |
| UA115789C2 (uk) * | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
| TWI660972B (zh) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗mcam抗體及相關使用方法 |
| BR112015003938A2 (pt) | 2012-09-14 | 2018-09-04 | Hoffmann La Roche | métodos de produção de polipeptídeos, de produção de aglutinantes multiespecíficos, de seleção de aglutinantes multiespecíficos, de seleção de anticorpos biespecíficos e de determinação de combinação, anticorpo biespecífico, formulação farmcêutica e uso de anticorpo biespecífico |
| US9926366B2 (en) | 2012-10-04 | 2018-03-27 | Novelmed Therapeutics, Inc. | Methods of treating a hemolytic disorder comprising administering anti-properdin antibodies |
| UA118441C2 (uk) | 2012-10-08 | 2019-01-25 | Протена Біосаєнсиз Лімітед | Антитіло, що розпізнає альфа-синуклеїн |
| CA2884220A1 (en) | 2012-10-08 | 2014-04-17 | F. Hoffmann-La Roche Ag | Cell penetrating peptides which bind irf5 |
| MX2015003616A (es) | 2012-10-08 | 2015-06-05 | Roche Glycart Ag | Anticuerpos sin fc que comprenden dos fragmentos fab y metodos de uso. |
| AU2013328580B2 (en) | 2012-10-12 | 2016-01-21 | Medimmune Limited | Pyrrolobenzodiazepines and conjugates thereof |
| IL238323B2 (en) | 2012-10-30 | 2023-11-01 | Esperance Pharmaceuticals Inc | Antibody/drug conjugates and methods of use |
| EP2914289B1 (en) | 2012-10-31 | 2019-05-22 | Takeda GmbH | Lyophilized formulation comprising gm-csf neutralizing compound |
| EP2727602A1 (en) * | 2012-10-31 | 2014-05-07 | Takeda GmbH | Method for preparation of a high concentration liquid formulation of an antibody |
| AR093297A1 (es) | 2012-10-31 | 2015-05-27 | Amgen Res Munich Gmbh | Formulacion liquida que comprende un compuesto neutralizante de gm-csf |
| RU2636043C2 (ru) | 2012-11-01 | 2017-11-17 | Эббви Инк. | Анти-vegf/dll4-иммуноглобулины с двойными вариабельными доменами и их применения |
| KR20150064205A (ko) | 2012-11-08 | 2015-06-10 | 에프. 호프만-라 로슈 아게 | Her3의 베타-헤어핀에 결합하는 her3 항원 결합 단백질 |
| PH12019501031A1 (en) | 2012-11-13 | 2022-11-14 | Genentech Inc | Anti-hemagglutinin antibodies and methods of use |
| US20140154255A1 (en) | 2012-11-30 | 2014-06-05 | Abbvie Biotherapeutics Inc. | Anti-vegf antibodies and their uses |
| KR20230156146A (ko) * | 2012-12-13 | 2023-11-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Dna 항체 작제물 및 그 이용 방법 |
| UA117466C2 (uk) * | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| MX367748B (es) * | 2012-12-21 | 2019-09-04 | Glenmark Pharmaceuticals Sa | Formulación de anticuerpo anti her2. |
| SG11201504414UA (en) | 2012-12-21 | 2015-07-30 | Hoffmann La Roche | Disulfide-linked multivalent mhc class i comprising multi-function proteins |
| WO2014116749A1 (en) | 2013-01-23 | 2014-07-31 | Genentech, Inc. | Anti-hcv antibodies and methods of using thereof |
| WO2015198217A2 (en) | 2013-02-08 | 2015-12-30 | Novartis Ag | Compositions and methods for long-acting antibodies targeting il-17 |
| TWI632159B (zh) | 2013-02-08 | 2018-08-11 | 諾華公司 | 抗-il-17a抗體及其於治療自體免疫及發炎病症之用途 |
| MX2015010791A (es) | 2013-02-22 | 2015-11-26 | Hoffmann La Roche | Metodos para tratar el cancer y prevenir la resistencia a farmacos. |
| CA2896259A1 (en) | 2013-02-26 | 2014-09-04 | Roche Glycart Ag | Anti-mcsp antibodies |
| CN105246511A (zh) | 2013-03-06 | 2016-01-13 | 豪夫迈·罗氏有限公司 | 治疗和预防癌症药物抗性的方法 |
| AR096927A1 (es) | 2013-03-12 | 2016-02-10 | Amgen Inc | INHIBIDORES POTENTES Y SELECTIVOS DE NaV1.7 |
| EP2970408B1 (en) | 2013-03-12 | 2018-01-10 | Amgen Inc. | Potent and selective inhibitors of nav1.7 |
| MX362970B (es) | 2013-03-13 | 2019-02-28 | Medimmune Ltd | Pirrolobenzodiazepinas y conjugados de las mismas. |
| MX365567B (es) * | 2013-03-13 | 2019-06-07 | Genentech Inc | Formulaciones de anticuerpo. |
| KR20150127199A (ko) | 2013-03-14 | 2015-11-16 | 제넨테크, 인크. | 항-b7-h4 항체 및 면역접합체 |
| US9562099B2 (en) | 2013-03-14 | 2017-02-07 | Genentech, Inc. | Anti-B7-H4 antibodies and immunoconjugates |
| US9968603B2 (en) | 2013-03-14 | 2018-05-15 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| HK1220916A1 (zh) | 2013-03-14 | 2017-05-19 | 基因泰克公司 | 治疗癌症和预防癌症药物抗性的方法 |
| KR20150130451A (ko) | 2013-03-15 | 2015-11-23 | 제넨테크, 인크. | 암 치료 방법 및 항암제 내성 예방을 위한 방법 |
| JP6568514B2 (ja) | 2013-03-15 | 2019-08-28 | エーシー イミューン エス.エー. | 抗タウ抗体及び使用方法 |
| CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
| SG10201701380TA (en) | 2013-03-15 | 2017-04-27 | Genentech Inc | Biomarkers and methods of treating pd-1 and pd-l1 related conditions |
| JP6527132B2 (ja) | 2013-03-15 | 2019-06-05 | ジェネンテック, インコーポレイテッド | 肝臓がんの診断及び治療のための組成物及び方法 |
| WO2014140361A1 (en) * | 2013-03-15 | 2014-09-18 | Takeda Gmbh | Formulation of an antibody and use thereof |
| CN105143265A (zh) | 2013-03-15 | 2015-12-09 | 豪夫迈·罗氏有限公司 | 抗CRTh2抗体及其用途 |
| ES2798307T3 (es) | 2013-03-15 | 2020-12-10 | Hoffmann La Roche | Composiciones de cultivo de células con antioxidantes y procedimientos para la producción de polipéptidos |
| CN105025925A (zh) * | 2013-03-15 | 2015-11-04 | 拜尔健康护理有限责任公司 | 抗-催乳素受体抗体制剂 |
| US10160793B2 (en) | 2013-03-15 | 2018-12-25 | Genentech, Inc. | Methods of treating inflammatory bowel disease using IL-22 Fc fusion proteins |
| JP6385423B2 (ja) | 2013-03-28 | 2018-09-05 | フォーサイト・ビジョン フォー・インコーポレーテッド | 治療物質送達用の眼移植片 |
| UA118028C2 (uk) | 2013-04-03 | 2018-11-12 | Рош Глікарт Аг | Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування |
| WO2014161570A1 (en) | 2013-04-03 | 2014-10-09 | Roche Glycart Ag | Antibodies against human il17 and uses thereof |
| EA201591643A1 (ru) | 2013-04-16 | 2016-02-29 | Дженентек, Инк. | Варианты пертузумаба и их аналитическая характеристика |
| ES2746136T3 (es) | 2013-04-29 | 2020-03-04 | Hoffmann La Roche | Anticuerpos modificados de unión a FcRn humano y procedimientos de uso |
| KR102266819B1 (ko) | 2013-04-29 | 2021-06-18 | 에프. 호프만-라 로슈 아게 | Fc-수용체 결합 개질된 비대칭 항체 및 이의 사용 방법 |
| SG11201508910WA (en) | 2013-04-29 | 2015-11-27 | Hoffmann La Roche | Fcrn-binding abolished anti-igf-1r antibodies and their use in the treatment of vascular eye diseases |
| JP2014214153A (ja) * | 2013-04-30 | 2014-11-17 | ニプロ株式会社 | 水溶液製剤およびその製造方法 |
| HRP20240107T1 (hr) | 2013-05-20 | 2024-04-12 | F. Hoffmann - La Roche Ag | Protutijela na transferinski receptor i postupci uporabe |
| US10513555B2 (en) | 2013-07-04 | 2019-12-24 | Prothena Biosciences Limited | Antibody formulations and methods |
| SG10201912985RA (en) | 2013-07-12 | 2020-02-27 | Ophthotech Corp | Methods for treating or preventing ophthalmological conditions |
| EP3027649B1 (en) | 2013-08-01 | 2020-04-01 | F.Hoffmann-La Roche Ag | Tnfa-il-17 bispecific antibodies |
| BR112016002198A2 (pt) * | 2013-08-14 | 2017-09-12 | Novartis Ag | métodos de tratamento de miosite por corpos de inclusão esporádica |
| KR20220045064A (ko) | 2013-08-30 | 2022-04-12 | 다케다 야쿠힌 고교 가부시키가이샤 | 류마티스성 관절염의 치료에서 또는 진통제로서 사용하기 위한 gm-csf 중화 항체 |
| HK1218124A1 (zh) | 2013-09-17 | 2017-02-03 | 豪夫迈.罗氏有限公司 | 使用抗lgr5抗体的方法 |
| EP4285928A3 (en) * | 2013-09-27 | 2024-03-13 | F. Hoffmann-La Roche AG | Anti-pdl1 antibody formulations |
| KR20160068855A (ko) | 2013-10-11 | 2016-06-15 | 제넨테크, 인크. | Nsp4 억제제 및 사용 방법 |
| RU2016115866A (ru) | 2013-10-11 | 2017-11-16 | Ф. Хоффманн-Ля Рош Аг | Мультиспецифические антитела с обменянными доменами и одинаковыми вариабельными доменами легкой цепи |
| EP3057615B1 (en) | 2013-10-18 | 2021-02-24 | F.Hoffmann-La Roche Ag | Anti-rspo antibodies and methods of use |
| WO2015061441A1 (en) | 2013-10-23 | 2015-04-30 | Genentech, Inc. | Methods of diagnosing and treating eosinophilic disorders |
| ES2875878T3 (es) | 2013-11-18 | 2021-11-11 | Formycon Ag | Composición farmacéutica de un anticuerpo anti-VEGF |
| PL3071597T3 (pl) | 2013-11-21 | 2020-11-30 | F.Hoffmann-La Roche Ag | Przeciwciała przeciwko alfa-synukleinie i sposoby stosowania |
| ES2983564T3 (es) | 2013-11-21 | 2024-10-23 | Genmab As | Formulación liofilizada de conjugado de anticuerpos y fármaco |
| TW201533060A (zh) | 2013-12-13 | 2015-09-01 | Genentech Inc | 抗cd33抗體及免疫結合物 |
| JP2017501157A (ja) | 2013-12-17 | 2017-01-12 | ジェネンテック, インコーポレイテッド | Pd−1軸結合アンタゴニスト及び抗cd20抗体を使用してがんを治療する方法 |
| JP6841656B2 (ja) | 2013-12-17 | 2021-03-10 | ジェネンテック, インコーポレイテッド | Pd−1軸結合アンタゴニスト及びタキサンを使用する癌の治療方法 |
| BR112016013963A2 (pt) | 2013-12-17 | 2017-10-10 | Genentech Inc | terapia de combinação compreendendo agonistas de ligação de ox40 e antagonistas de ligação do eixo de pd-1 |
| LT3083680T (lt) | 2013-12-20 | 2020-04-10 | F. Hoffmann-La Roche Ag | Humanizuoti anti-tau(ps422) antikūnai ir jų naudojimo būdai |
| CN106029087A (zh) | 2013-12-20 | 2016-10-12 | 印第安纳大学研究及科技有限公司 | 脂质化肠降血糖素受体配体人免疫球蛋白fc区融合多肽 |
| TWI728373B (zh) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | 抗體及使用方法 |
| PL3089996T3 (pl) | 2014-01-03 | 2021-12-13 | F. Hoffmann-La Roche Ag | Dwuswoiste przeciwciała przeciw haptenowi/przeciw receptorowi występującemu w barierze krew-mózg, ich kompleksy i ich zastosowanie jako przenośniki wahadłowe występujące w barierze krew-mózg |
| MX373017B (es) | 2014-01-03 | 2020-04-28 | Hoffmann La Roche | Conjugados de toxina polipeptidica-anticuerpo unidos covalentemente. |
| RU2694981C2 (ru) | 2014-01-03 | 2019-07-18 | Ф. Хоффманн-Ля Рош Аг | Ковалентно связанные конъюгаты хеликар-антитело против хеликара и их применения |
| JP6557664B2 (ja) | 2014-01-06 | 2019-08-07 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 一価の血液脳関門シャトルモジュール |
| CN105899534B (zh) | 2014-01-15 | 2020-01-07 | 豪夫迈·罗氏有限公司 | 具有修饰的FCRN和保持的蛋白A结合性质的Fc区变体 |
| SG11201605903SA (en) | 2014-01-24 | 2016-08-30 | Genentech Inc | Methods of using anti-steap1 antibodies and immunoconjugates |
| TWI705824B (zh) | 2014-02-08 | 2020-10-01 | 美商建南德克公司 | 治療阿茲海默症之方法 |
| EP3102230B1 (en) | 2014-02-08 | 2021-04-28 | F. Hoffmann-La Roche AG | Methods of treating alzheimer's disease |
| JP6571115B2 (ja) | 2014-02-12 | 2019-09-04 | ジェネンテック, インコーポレイテッド | 抗jagged1抗体及び使用方法 |
| WO2015127405A2 (en) | 2014-02-21 | 2015-08-27 | Genentech, Inc. | Anti-il-13/il-17 bispecific antibodies and uses thereof |
| WO2015130172A1 (en) | 2014-02-28 | 2015-09-03 | Merus B.V. | Antibodies that bind egfr and erbb3 |
| JP6967853B2 (ja) | 2014-02-28 | 2021-11-17 | メルス ナムローゼ フェンノートシャップ | ErbB−2およびErbB−3に結合する抗体 |
| EP3116911B8 (en) * | 2014-03-12 | 2019-10-23 | Prothena Biosciences Limited | Anti-mcam antibodies and associated methods of use |
| KR20160134687A (ko) | 2014-03-21 | 2016-11-23 | 에프. 호프만-라 로슈 아게 | 항체의 생체내 반감기의 시험관내 예측방법 |
| WO2015140591A1 (en) | 2014-03-21 | 2015-09-24 | Nordlandssykehuset Hf | Anti-cd14 antibodies and uses thereof |
| HRP20192285T1 (hr) | 2014-03-31 | 2020-03-06 | F. Hoffmann - La Roche Ag | Anti-ox40 protutijela i postupci uporabe |
| CA2943834A1 (en) | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
| MX384635B (es) | 2014-04-16 | 2025-03-14 | Biosimilars Newco Ltd | Formulaciones de proteína estables que comprenden un exceso molar de sorbitol. |
| JP2015209384A (ja) * | 2014-04-24 | 2015-11-24 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | 医薬製剤 |
| KR20160141857A (ko) | 2014-04-25 | 2016-12-09 | 제넨테크, 인크. | 트라스투주맙-mcc-dm1 및 퍼투주맙을 이용하는 초기 유방암의 치료방법 |
| CN105012949A (zh) * | 2014-04-28 | 2015-11-04 | 上海药明康德新药开发有限公司 | 重组人抗人TNFα单克隆抗体的制剂 |
| WO2015179658A2 (en) | 2014-05-22 | 2015-11-26 | Genentech, Inc. | Anti-gpc3 antibodies and immunoconjugates |
| ES2572919T3 (es) | 2014-05-23 | 2016-06-03 | Ares Trading S.A. | Composición farmacéutica líquida |
| EP3050557A1 (en) | 2014-05-23 | 2016-08-03 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP2946767B1 (en) | 2014-05-23 | 2016-10-05 | Ares Trading S.A. | Liquid pharmaceutical composition |
| EP3146071B1 (en) | 2014-05-23 | 2020-09-02 | F. Hoffmann-La Roche AG | Mit biomarkers and methods using the same |
| MX2016016233A (es) | 2014-06-11 | 2017-03-31 | Genentech Inc | Anticuerpos anti-lgr5 y sus usos. |
| WO2015191986A1 (en) | 2014-06-13 | 2015-12-17 | Genentech, Inc. | Methods of treating and preventing cancer drug resistance |
| RU2705299C2 (ru) | 2014-06-26 | 2019-11-06 | Ф. Хоффманн-Ля Рош Аг | Антитела против 5-бром-2'-дезоксиуридина и способы применения |
| AR100978A1 (es) | 2014-06-26 | 2016-11-16 | Hoffmann La Roche | LANZADERAS CEREBRALES DE ANTICUERPO HUMANIZADO ANTI-Tau(pS422) Y USOS DE LAS MISMAS |
| MX2017000363A (es) | 2014-07-11 | 2017-04-27 | Genentech Inc | Inhibicion de la via de notch. |
| ES2992100T3 (es) | 2014-07-15 | 2024-12-09 | Forsight Vision4 Inc | Dispositivo de administración de implante ocular |
| US10507241B2 (en) | 2014-07-24 | 2019-12-17 | Boehringer Ingelheim International Gmbh | Biomarkers useful in the treatment of IL-23A related diseases |
| JP2017524034A (ja) | 2014-08-08 | 2017-08-24 | フォーサイト・ビジョン フォー・インコーポレーテッドForsight Vision4, Inc. | 受容体型チロシンキナーゼ阻害剤の安定で可溶な製剤およびその調製の方法 |
| ES3034398T3 (en) | 2014-08-28 | 2025-08-18 | Bioatla Inc | Conditionally active chimeric antigen receptors for modified t-cells |
| EA039598B9 (ru) | 2014-09-03 | 2022-03-10 | Бёрингер Ингельхайм Интернациональ Гмбх | Соединение, нацеленное на ил-23а и фно-альфа, и его применение |
| CN106687141A (zh) | 2014-09-10 | 2017-05-17 | 麦迪穆有限责任公司 | 吡咯并苯并二氮杂卓及其缀合物 |
| BR112017003236A2 (pt) | 2014-09-12 | 2017-11-28 | Genentech Inc | anticorpos elaborados com cisteína, conjugados de droga e anticorpos, método de preparação de conjugado de droga e anticorpo e composição farmacêutica |
| JP6943760B2 (ja) | 2014-09-12 | 2021-10-06 | ジェネンテック, インコーポレイテッド | 抗b7−h4抗体及び免疫複合体 |
| EA201790569A1 (ru) | 2014-09-12 | 2017-08-31 | Дженентек, Инк. | Антитела и иммуноконъюгаты против cll-1 |
| SG11201701623UA (en) | 2014-09-12 | 2017-03-30 | Genentech Inc | Anti-her2 antibodies and immunoconjugates |
| EP3193932B1 (en) * | 2014-09-15 | 2023-04-26 | F. Hoffmann-La Roche AG | Antibody formulations |
| KR20170055521A (ko) | 2014-09-17 | 2017-05-19 | 제넨테크, 인크. | 항-her2 항체를 포함하는 면역콘주게이트 |
| SI3262071T1 (sl) | 2014-09-23 | 2020-07-31 | F. Hoffmann-La Roche Ag | Način uporabe imunokonjugatov proti CD79b |
| TW201628649A (zh) * | 2014-10-09 | 2016-08-16 | 再生元醫藥公司 | 減少醫藥調配物中微可見顆粒之方法 |
| JP2017536102A (ja) | 2014-10-16 | 2017-12-07 | ジェネンテック, インコーポレイテッド | 抗アルファ−シヌクレイン抗体及び使用方法 |
| SG11201703219WA (en) * | 2014-10-24 | 2017-05-30 | Astrazeneca Ab | Combination |
| WO2016073157A1 (en) | 2014-11-06 | 2016-05-12 | Genentech, Inc. | Anti-ang2 antibodies and methods of use thereof |
| BR112017006591A2 (pt) | 2014-11-06 | 2018-01-16 | Hoffmann La Roche | polipeptídeo heterodimérico, formulação farmacêutica e uso de um polipeptídeo heterodimérico |
| BR112017006178A2 (pt) | 2014-11-06 | 2018-05-02 | F. Hoffmann-La Roche Ag | região fc, anticorpos, formulação farmacêutica e usos dos anticorpos |
| TWI806150B (zh) * | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| AU2015346450B2 (en) | 2014-11-10 | 2020-01-30 | Forsight Vision4, Inc. | Expandable drug delivery devices and method of use |
| WO2016077369A1 (en) | 2014-11-10 | 2016-05-19 | Genentech, Inc. | Animal model for nephropathy and agents for treating the same |
| EA201791029A1 (ru) | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
| US9926375B2 (en) | 2014-11-12 | 2018-03-27 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
| US10155820B2 (en) | 2014-11-12 | 2018-12-18 | Tracon Pharmaceuticals, Inc. | Anti-endoglin antibodies and uses thereof |
| CN114634570B (zh) | 2014-11-14 | 2025-05-06 | 豪夫迈·罗氏有限公司 | 包含tnf家族配体三聚体的抗原结合分子 |
| KR20170096112A (ko) | 2014-11-17 | 2017-08-23 | 제넨테크, 인크. | Ox40 결합 효능제 및 pd-1 축 결합 길항제를 포함하는 조합 요법 |
| WO2016081639A1 (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Antibodies against bace1 and use thereof for neural disease immunotherapy |
| JP6779876B2 (ja) | 2014-11-19 | 2020-11-04 | ジェネンテック, インコーポレイテッド | 抗トランスフェリン受容体抗体及びその使用方法 |
| JP6993228B2 (ja) | 2014-11-19 | 2022-03-03 | ジェネンテック, インコーポレイテッド | 抗トランスフェリン受容体/抗bace1多重特異性抗体および使用方法 |
| HRP20240959T1 (hr) | 2014-11-20 | 2024-10-25 | F. Hoffmann - La Roche Ag | Kombinirana terapija bispecifičnom antigen vezujućom molekulom koja aktivira t stanice i antagonistom vezivanja osi pd-1 |
| JP6721590B2 (ja) | 2014-12-03 | 2020-07-15 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 多重特異性抗体 |
| JP6802158B2 (ja) | 2014-12-05 | 2020-12-16 | ジェネンテック, インコーポレイテッド | 抗CD79b抗体及び使用方法 |
| CN104922668B (zh) * | 2014-12-10 | 2019-08-23 | 信达生物制药(苏州)有限公司 | 一种稳定的抗vegf抗体制剂及其用途 |
| SG11201703750XA (en) | 2014-12-10 | 2017-06-29 | Genentech Inc | Blood brain barrier receptor antibodies and methods of use |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| RU2698205C2 (ru) | 2014-12-18 | 2019-08-23 | Ф. Хоффманн-Ля Рош Аг | Способ определения антител, вызывающих комплемент-зависимую цитотоксичность |
| KR102650420B1 (ko) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| TWI617580B (zh) | 2014-12-19 | 2018-03-11 | 中外製藥股份有限公司 | 抗c5抗體及使用方法 |
| AR103173A1 (es) | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| WO2016109822A1 (en) * | 2014-12-31 | 2016-07-07 | Novelmed Therapeutics, Inc. | Formulation of aglycosylated therapeutic antibodies |
| HK1246810A1 (zh) | 2015-01-08 | 2018-09-14 | Biogen Ma Inc. | Lingo-1对抗药及用於治疗脱髓鞘疾病的用途 |
| WO2016117346A1 (en) | 2015-01-22 | 2016-07-28 | Chugai Seiyaku Kabushiki Kaisha | A combination of two or more anti-c5 antibodies and methods of use |
| HK1247215A1 (zh) | 2015-01-26 | 2018-09-21 | Macrogenics, Inc. | 包含dr5-结合结构域的多价分子 |
| US10894083B2 (en) * | 2015-01-28 | 2021-01-19 | Pfizer Inc. | Stable aqueous anti-vascular endothelial growth factor (VEGF) antibody formulation |
| CN105985435B (zh) * | 2015-01-30 | 2019-10-15 | 嘉和生物药业有限公司 | 全人源her2抗体的突变抗体及其编码基因和应用 |
| IL307578A (en) | 2015-02-04 | 2023-12-01 | Boehringer Ingelheim Int | Methods of treating inflammatory diseases |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| EP3256160A1 (en) * | 2015-02-13 | 2017-12-20 | Sanofi | Stable liquid formulation for monoclonal antibodies |
| EP4269440A3 (en) | 2015-02-27 | 2024-02-28 | Chugai Seiyaku Kabushiki Kaisha | Composition for treating il-6-related diseases |
| AR103935A1 (es) | 2015-03-16 | 2017-06-14 | Genentech Inc | Métodos de detección y cuantificación de il-13 y sus usos en el diagnóstico y tratamiento de enfermedades asociadas a th-2 |
| WO2016146833A1 (en) | 2015-03-19 | 2016-09-22 | F. Hoffmann-La Roche Ag | Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance |
| CN107810197B (zh) | 2015-04-24 | 2022-10-25 | 豪夫迈·罗氏有限公司 | 鉴定包含结合多肽的细菌的方法 |
| EP3778640A1 (en) | 2015-05-01 | 2021-02-17 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use |
| CA2985001A1 (en) | 2015-05-07 | 2016-11-10 | Novimmune Sa | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of cxcl9 and other biomarkers |
| US11091543B2 (en) | 2015-05-07 | 2021-08-17 | Swedish Orphan Biovitrum Ag | Methods, compositions and dosing regimens for treating or preventing interferon-gamma related indications |
| CN108027360A (zh) * | 2015-05-29 | 2018-05-11 | 爱科谱迅病理研究公司 | 用于最优癌症治疗的定量Her2蛋白质 |
| HK1250723A1 (zh) | 2015-05-29 | 2019-01-11 | F. Hoffmann-La Roche Ag | 人源化抗埃博拉病毒糖蛋白抗体和使用方法 |
| HUE068105T2 (hu) | 2015-05-30 | 2024-12-28 | Hoffmann La Roche | Eljárások korábban kezeletlen her2-pozitív metasztatikus emlõrák kezelésére |
| JP2018516933A (ja) | 2015-06-02 | 2018-06-28 | ジェネンテック, インコーポレイテッド | 抗il−34抗体を使用して神経学的疾患を治療するための組成物及び方法 |
| JP6793134B2 (ja) | 2015-06-05 | 2020-12-02 | ジェネンテック, インコーポレイテッド | 抗tau抗体及び使用方法 |
| AU2016274585A1 (en) | 2015-06-08 | 2017-12-14 | Genentech, Inc. | Methods of treating cancer using anti-OX40 antibodies |
| MX2017015937A (es) | 2015-06-08 | 2018-12-11 | Genentech Inc | Métodos de tratamiento del cáncer con anticuerpos anti-ox40 y antagonistas de unión al eje de pd-1. |
| CN108064246A (zh) | 2015-06-15 | 2018-05-22 | 基因泰克公司 | 抗体和免疫结合物 |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| CN107847568B (zh) | 2015-06-16 | 2022-12-20 | 豪夫迈·罗氏有限公司 | 抗cll-1抗体和使用方法 |
| EP3310811B1 (en) | 2015-06-16 | 2021-06-16 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| US10323094B2 (en) | 2015-06-16 | 2019-06-18 | Genentech, Inc. | Humanized and affinity matured antibodies to FcRH5 and methods of use |
| WO2016205320A1 (en) | 2015-06-17 | 2016-12-22 | Genentech, Inc. | Methods of treating locally advanced or metastatic breast cancers using pd-1 axis binding antagonists and taxanes |
| CA2986592A1 (en) | 2015-06-17 | 2016-12-22 | Genentech, Inc. | Anti-her2 antibodies and methods of use |
| KR101808234B1 (ko) * | 2015-06-23 | 2017-12-12 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제 |
| JP7021955B2 (ja) | 2015-06-24 | 2022-03-03 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Her2及び血液脳関門受容体に特異的な三重特異性抗体及び使用方法 |
| AR105089A1 (es) | 2015-06-24 | 2017-09-06 | Hoffmann La Roche | ANTICUERPOS ANTI-TAU(pS422) HUMANIZADOS Y MÉTODOS DE UTILIZACIÓN |
| AU2016282334B2 (en) | 2015-06-24 | 2022-07-21 | F. Hoffmann-La Roche Ag | Anti-transferrin receptor antibodies with tailored affinity |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| EA201890519A1 (ru) | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
| KR102669174B1 (ko) * | 2015-08-19 | 2024-06-10 | 아스트라제네카 아베 | 안정한 항-ifnar1 제형 |
| JP6914919B2 (ja) | 2015-08-28 | 2021-08-04 | ジェネンテック, インコーポレイテッド | 抗ヒプシン抗体及びその使用 |
| MX2018003005A (es) | 2015-09-18 | 2018-04-11 | Chugai Pharmaceutical Co Ltd | Anticuerpos que se unen a interleucina 8 (il-8) y sus usos. |
| SG10201911226QA (en) | 2015-09-23 | 2020-01-30 | Genentech Inc | Optimized variants of anti-vegf antibodies |
| JP6903640B2 (ja) | 2015-09-24 | 2021-07-14 | ジェネンテック, インコーポレイテッド | てんかんの治療方法 |
| KR20180083313A (ko) | 2015-09-24 | 2018-07-20 | 에이비비트로, 엘엘씨 | Hiv 항체 조성물 및 사용 방법 |
| SI3353210T1 (sl) | 2015-09-25 | 2025-03-31 | F. Hoffmann-La Roche Ag | Protitelesa proti TIGIT in postopki uporabe |
| JP6921062B2 (ja) * | 2015-09-28 | 2021-08-18 | スーヂョウ サンケイディア バイオファーマスーティカルズ カンパニー リミテッド | 安定な抗pd−1抗体医薬製剤および医薬におけるその適用 |
| AR106188A1 (es) | 2015-10-01 | 2017-12-20 | Hoffmann La Roche | Anticuerpos anti-cd19 humano humanizados y métodos de utilización |
| MA43345A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation |
| AR106189A1 (es) | 2015-10-02 | 2017-12-20 | Hoffmann La Roche | ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO |
| IL257858B (en) | 2015-10-02 | 2022-09-01 | Hoffmann La Roche | Anti-pd1 antibodies and methods of use |
| AU2016329120B2 (en) | 2015-10-02 | 2023-04-13 | F. Hoffmann-La Roche Ag | Bispecific antibodies specific for a costimulatory TNF receptor |
| PE20231655A1 (es) | 2015-10-02 | 2023-10-17 | Hoffmann La Roche | Anticuerpos biespecificos contra el cd20 humano y el receptor de transferrina humano y metodos de uso |
| EP3150636A1 (en) | 2015-10-02 | 2017-04-05 | F. Hoffmann-La Roche AG | Tetravalent multispecific antibodies |
| SI3356411T1 (sl) | 2015-10-02 | 2021-09-30 | F. Hoffmann-La Roche Ag | Bispecifična protitelesa, specifična za PD1 in TIM3 |
| LT3359572T (lt) | 2015-10-06 | 2025-02-10 | F. Hoffmann-La Roche Ag | Išsėtinės sklerozės gydymo būdas |
| JP7074665B2 (ja) | 2015-10-07 | 2022-05-24 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 共刺激tnf受容体に対する四価の二重特異性抗体発明の分野 |
| MA45326A (fr) | 2015-10-20 | 2018-08-29 | Genentech Inc | Conjugués calichéamicine-anticorps-médicament et procédés d'utilisation |
| SG11201803359VA (en) | 2015-10-23 | 2018-05-30 | Merus Nv | Binding molecules that inhibit cancer growth |
| MA44334A (fr) | 2015-10-29 | 2018-09-05 | Novartis Ag | Conjugués d'anticorps comprenant un agoniste du récepteur de type toll |
| EP3184547A1 (en) | 2015-10-29 | 2017-06-28 | F. Hoffmann-La Roche AG | Anti-tpbg antibodies and methods of use |
| TW201730211A (zh) | 2015-10-30 | 2017-09-01 | 建南德克公司 | 抗因子d抗體及結合物 |
| SI3368579T1 (sl) | 2015-10-30 | 2022-04-29 | F.Hoffmann-La Roche Ag | Tečajni modificirani fragmenti protitelesa in metode priprave |
| EP4671281A2 (en) | 2015-11-08 | 2025-12-31 | F. Hoffmann-La Roche AG | MULTISPECIFIC ANTIBODY SCREENING METHODS |
| CA3004830A1 (en) | 2015-11-11 | 2017-05-18 | Opi Vi- Ip Holdco Llc | Composition and methods for anti-tnfr2 antibodies |
| WO2017087280A1 (en) | 2015-11-16 | 2017-05-26 | Genentech, Inc. | Methods of treating her2-positive cancer |
| CN113069681B (zh) | 2015-11-20 | 2022-12-23 | 弗赛特影像4股份有限公司 | 制造用于缓释药物递送的治疗装置的方法 |
| BR112018010211A2 (pt) * | 2015-12-07 | 2019-02-05 | Merck Patent Gmbh | formulação farmacêutica aquosa compreendendo anticorpo anti-pd-l1 avelumab |
| TWI605057B (zh) | 2015-12-18 | 2017-11-11 | 中外製藥股份有限公司 | 抗肌抑素抗體、含變異fc區之多肽及使用方法 |
| TWI747936B (zh) | 2015-12-18 | 2021-12-01 | 日商中外製藥股份有限公司 | 抗c5抗體及使用方法 |
| AU2017205089B2 (en) | 2016-01-08 | 2023-10-05 | F. Hoffmann-La Roche Ag | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
| MA43859A (fr) | 2016-01-11 | 2018-11-21 | Novartis Ag | Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion |
| WO2017121867A1 (en) * | 2016-01-13 | 2017-07-20 | Genmab A/S | Formulation for antibody and drug conjugate thereof |
| EP3405489A1 (en) | 2016-01-20 | 2018-11-28 | Genentech, Inc. | High dose treatments for alzheimer's disease |
| BR112018017322A2 (pt) | 2016-02-24 | 2019-01-02 | Biomarin Pharm Inc | proteínas de fusão de enzima lisossômica terapêuticas direcionadas, formulações associadas e usos das mesmas |
| SMT202100416T1 (it) * | 2016-03-02 | 2021-09-14 | Eisai R&D Man Co Ltd | Coniugati anticorpo-farmaco a base di eribulina e metodi di uso |
| EP4112641A1 (en) | 2016-03-15 | 2023-01-04 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
| EP3231813A1 (en) | 2016-03-29 | 2017-10-18 | F. Hoffmann-La Roche AG | Trimeric costimulatory tnf family ligand-containing antigen binding molecules |
| BR112018070383A2 (pt) | 2016-04-05 | 2019-02-05 | Forsight Vision4 Inc | dispositivos para aplicação de fármaco oculares implantáveis |
| EP3865511A1 (en) | 2016-04-14 | 2021-08-18 | F. Hoffmann-La Roche AG | Anti-rspo3 antibodies and methods of use |
| WO2017180842A1 (en) | 2016-04-15 | 2017-10-19 | Bioatla, Llc | Anti-axl antibodies, antibody fragments and their immunoconjugates and uses thereof |
| BR112018069890A2 (pt) | 2016-05-02 | 2019-02-05 | Hoffmann La Roche | polipeptídio de fusão que se liga de forma específica a um alvo, polipeptídio de fusão dimérico, ácido nucleico isolado, par de ácidos nucleicos isolados, célula hospedeira, método para produzir um polipeptídio de fusão, imunoconjugado, formulação farmacêutica, polipeptídio de fusão e uso do polipeptídio de fusão |
| JP7285076B2 (ja) | 2016-05-11 | 2023-06-01 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Tnfファミリーリガンドトリマーとテネイシン結合部分とを含む抗原結合分子 |
| EP3243836A1 (en) | 2016-05-11 | 2017-11-15 | F. Hoffmann-La Roche AG | C-terminally fused tnf family ligand trimer-containing antigen binding molecules |
| CN109071640B (zh) | 2016-05-11 | 2022-10-18 | 豪夫迈·罗氏有限公司 | 经修饰抗生腱蛋白抗体及使用方法 |
| EP3243832A1 (en) | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
| CN109311987A (zh) | 2016-05-13 | 2019-02-05 | 生物蛋白有限公司 | 抗ror2抗体、抗体片段和它们的免疫缀合物以及其用途 |
| RS62040B1 (sr) | 2016-06-02 | 2021-07-30 | Abbvie Inc | Agonist receptora glukokortikoida i njegovi imunokonjugati |
| US10639378B2 (en) | 2016-06-06 | 2020-05-05 | Genentech, Inc. | Silvestrol antibody-drug conjugates and methods of use |
| IL262996B2 (en) | 2016-06-06 | 2024-03-01 | Hoffmann La Roche | Fusion proteins for ophthalmology with increased eye retention |
| TWI760396B (zh) | 2016-06-17 | 2022-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素抗體及使用方法 |
| WO2017223405A1 (en) | 2016-06-24 | 2017-12-28 | Genentech, Inc. | Anti-polyubiquitin multispecific antibodies |
| TN2018000443A1 (en) * | 2016-06-30 | 2020-06-15 | Celltrion Inc | Stable liquid pharmaceutical preparation |
| WO2018007314A1 (en) | 2016-07-04 | 2018-01-11 | F. Hoffmann-La Roche Ag | Novel antibody format |
| EP3494139B1 (en) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
| TW202300168A (zh) | 2016-08-05 | 2023-01-01 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| CN109476748B (zh) | 2016-08-08 | 2023-05-23 | 豪夫迈·罗氏有限公司 | 用于癌症的治疗和诊断方法 |
| SG10201607778XA (en) | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
| AU2017330405B2 (en) | 2016-09-23 | 2024-02-01 | Genentech, Inc. | Uses of IL-13 antagonists for treating atopic dermatitis |
| EP3516396B1 (en) | 2016-09-26 | 2024-11-13 | F. Hoffmann-La Roche AG | Predicting response to pd-1 axis inhibitors |
| WO2018069289A1 (en) | 2016-10-11 | 2018-04-19 | Medimmune Limited | Antibody-drug conjugates with immune-mediated therapy agents |
| JP2019535250A (ja) | 2016-10-29 | 2019-12-12 | ジェネンテック, インコーポレイテッド | 抗mic抗体及び使用方法 |
| KR20190075114A (ko) | 2016-11-04 | 2019-06-28 | 제넨테크, 인크. | Her2-양성 유방암의 치료 |
| WO2018093821A1 (en) | 2016-11-15 | 2018-05-24 | Genentech, Inc. | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies |
| TW201829463A (zh) | 2016-11-18 | 2018-08-16 | 瑞士商赫孚孟拉羅股份公司 | 抗hla-g抗體及其用途 |
| JOP20190100A1 (ar) | 2016-11-19 | 2019-05-01 | Potenza Therapeutics Inc | بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها |
| KR102532256B1 (ko) | 2016-11-21 | 2023-05-12 | 쿠레아브 게엠베하 | 항-gp73 항체 및 면역접합체 |
| JP7116059B2 (ja) | 2016-11-21 | 2022-08-09 | ジャスト-エヴォテック バイオロジックス、インコーポレイテッド | アフリベルセプト製剤及びその使用 |
| MY198942A (en) | 2016-12-07 | 2023-10-03 | Genentech Inc | Anti-tau antibodies and methods of use |
| CN110248959B (zh) | 2016-12-07 | 2023-06-30 | 基因泰克公司 | 抗tau抗体和使用方法 |
| KR20190095921A (ko) | 2016-12-12 | 2019-08-16 | 제넨테크, 인크. | 항-pd-l1 항체 및 안티안드로겐을 사용하여 암을 치료하는 방법 |
| US20200315540A1 (en) | 2016-12-14 | 2020-10-08 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-1 inhibitor |
| CA3046019A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a tlr modulator |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| US11134889B2 (en) | 2016-12-14 | 2021-10-05 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a SMAD7 inhibitor |
| CA3045307A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| CN110072519A (zh) | 2016-12-14 | 2019-07-30 | 普罗根尼蒂公司 | 使用jak抑制剂治疗胃肠道疾病及装置 |
| WO2018112255A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an immunosuppressant |
| EP4233902A3 (en) | 2016-12-14 | 2024-02-28 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| KR20190095931A (ko) | 2016-12-14 | 2019-08-16 | 프로제너티, 인크. | 섭취가능한 디바이스를 사용하여 방출된 il-12/il-23 저해제로의 위장관 질환의 치료 |
| CA3045310A1 (en) | 2016-12-14 | 2018-06-21 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| AU2017380981B2 (en) | 2016-12-19 | 2025-01-30 | F. Hoffmann-La Roche Ag | Combination therapy with targeted 4-1BB (CD137) agonists |
| IL267406B2 (en) | 2016-12-20 | 2025-05-01 | Hoffmann La Roche | Combination therapy of anti-cd20/anti-cd3 bispecific antibodies and 4-1bb (cd137) agonists |
| AU2017384276B9 (en) | 2016-12-21 | 2020-11-26 | F. Hoffmann-La Roche Ag | In vitro glycoengineering of antibodies |
| IL267352B2 (en) | 2016-12-21 | 2023-10-01 | Hoffmann La Roche | Method for in vitro glycoengineering of antibodies |
| WO2018114878A1 (en) | 2016-12-21 | 2018-06-28 | F. Hoffmann-La Roche Ag | Re-use of enzymes in in vitro glycoengineering of antibodies |
| CA3044686A1 (en) | 2016-12-22 | 2018-06-28 | Genentech, Inc. | Methods and formulations for reducing reconstitution time of lyophilized polypeptides |
| BR112019012667A2 (pt) | 2016-12-23 | 2020-02-11 | Novartis Ag | Anticorpos do fator xi e métodos de uso |
| JOP20190134A1 (ar) | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| CN108239150A (zh) | 2016-12-24 | 2018-07-03 | 信达生物制药(苏州)有限公司 | 抗pcsk9抗体及其用途 |
| KR102313262B1 (ko) | 2016-12-28 | 2021-10-14 | 제넨테크, 인크. | 진행성 her2 발현 암의 치료 |
| BR112019013189A2 (pt) | 2017-01-03 | 2019-12-10 | Hoffmann La Roche | moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa |
| US10849849B2 (en) | 2017-01-17 | 2020-12-01 | Genentech Inc. | Subcutaneous HER2 antibody formulations |
| AR110873A1 (es) | 2017-02-10 | 2019-05-08 | Genentech Inc | Anticuerpos contra triptasa, composiciones de estos y usos de estos |
| AU2018227036B2 (en) * | 2017-03-01 | 2021-07-08 | Medimmune Limited | Formulations of monoclonal antibodies |
| ES2969041T3 (es) | 2017-03-02 | 2024-05-16 | Genentech Inc | Tratamiento adyuvante del cáncer de mama positivo para HER2 |
| JP7227151B2 (ja) | 2017-03-22 | 2023-02-21 | ジェネンテック, インコーポレイテッド | 眼障害の治療のために最適化された抗体組成物 |
| CN108623686A (zh) | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | 抗ox40抗体及其用途 |
| EP3601337A1 (en) | 2017-03-28 | 2020-02-05 | Genentech, Inc. | Methods of treating neurodegenerative diseases |
| CN110382542B (zh) | 2017-03-29 | 2023-06-09 | 豪夫迈·罗氏有限公司 | 针对共刺激性tnf受体的双特异性抗原结合分子 |
| WO2018178074A1 (en) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Trimeric antigen binding molecules specific for a costimulatory tnf receptor |
| WO2018178055A1 (en) | 2017-03-29 | 2018-10-04 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecule for a costimulatory tnf receptor |
| CA3054156A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist |
| US20210401895A1 (en) | 2017-03-30 | 2021-12-30 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with live biotherapeutics |
| JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
| EP4108183A1 (en) | 2017-03-30 | 2022-12-28 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| CA3054159A1 (en) | 2017-03-30 | 2018-10-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor |
| WO2018183932A1 (en) | 2017-03-30 | 2018-10-04 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor |
| US11780925B2 (en) | 2017-03-31 | 2023-10-10 | Merus N.V. | ErbB-2 and ErbB3 binding bispecific antibodies for use in the treatment of cells that have an NRG1 fusion gene |
| ES2986026T3 (es) | 2017-03-31 | 2024-11-08 | Meiji Seika Pharma Co Ltd | Formulación acuosa, formulación acuosa en inyector, agente desagregante de proteínas de anticuerpos y método de desagregación de proteínas de anticuerpos |
| KR102364599B1 (ko) | 2017-04-04 | 2022-02-21 | 에프. 호프만-라 로슈 아게 | Cd40 및 fap에 특이적으로 결합할 수 있는 새로운 이중특이적 항원 결합 분자 |
| DK3606955T3 (da) | 2017-04-05 | 2025-01-13 | Hoffmann La Roche | Bispecifikke antistoffer, der specifikt binder sig til PD1 og LAG3 |
| MX2019011916A (es) | 2017-04-05 | 2020-01-09 | Hoffmann La Roche | Anticuerpos anti-lag3. |
| CN108686205B (zh) * | 2017-04-07 | 2021-12-10 | 海正生物制药有限公司 | 英夫利西单抗冻干制剂 |
| CN108686204A (zh) * | 2017-04-07 | 2018-10-23 | 浙江海正药业股份有限公司 | 包含组氨酸缓冲体系的英夫利西单抗组合物 |
| EP3609537A1 (en) | 2017-04-13 | 2020-02-19 | H. Hoffnabb-La Roche Ag | An interleukin-2 immunoconjugate, a cd40 agonist, and optionally a pd-1 axis binding antagonist for use in methods of treating cancer |
| EP3610042A1 (en) | 2017-04-14 | 2020-02-19 | H. Hoffnabb-La Roche Ag | Diagnostic and therapeutic methods for cancer |
| KR20190141686A (ko) | 2017-04-21 | 2019-12-24 | 제넨테크, 인크. | 질환 치료를 위한 klk5 길항제의 용도 |
| AU2018258263A1 (en) | 2017-04-24 | 2019-10-24 | Genentech, Inc. | ErbB2/Her2 mutations in the transmembrane or juxtamembrane domain |
| MX2019012793A (es) | 2017-04-27 | 2020-02-13 | Tesaro Inc | Agentes anticuerpos dirigidos contra el gen de activación de linfocitos-3 (lag-3) y usos de los mismos. |
| AR111651A1 (es) | 2017-04-28 | 2019-08-07 | Novartis Ag | Conjugados de anticuerpos que comprenden agonistas del receptor de tipo toll y terapias de combinación |
| CA3060581A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
| EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| TWI797124B (zh) | 2017-05-05 | 2023-04-01 | 香港商安立璽榮生醫(香港)有限公司 | 抗干擾素-γ之抗體及其應用 |
| CA3063324A1 (en) | 2017-05-16 | 2018-11-22 | Bhami's Research Laboratory, Pvt. Ltd. | High concentration protein formulations with reduced viscosity |
| BR112019024230A2 (pt) | 2017-05-17 | 2020-06-09 | Merus N.V. | combinação de um anticorpo bispecífico erbb-2 / erbb-3 com terapia endócrina para câncer de mama |
| AU2018269498A1 (en) | 2017-05-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Reduction of application-related side reaction of a therapeutic antibody |
| CN118356488A (zh) * | 2017-05-30 | 2024-07-19 | 百时美施贵宝公司 | 包含抗lag-3抗体或抗lag-3抗体和抗pd-1或抗pd-l1抗体的组合物 |
| EP3418302A1 (en) | 2017-06-19 | 2018-12-26 | F. Hoffmann-La Roche AG | Administration routes for immune agonists |
| CN110506058A (zh) | 2017-06-02 | 2019-11-26 | 豪夫迈·罗氏有限公司 | 免疫激动剂的施用路径 |
| MX2020000957A (es) | 2017-07-26 | 2020-07-22 | Forty Seven Inc | Anticuerpos anti-sirp-alfa y metodos relacionados. |
| AU2018308930A1 (en) | 2017-07-28 | 2020-02-06 | F. Hoffmann-La Roche Ag | Bispecific antibody formulation |
| SG11202001050PA (en) | 2017-08-09 | 2020-03-30 | Merus Nv | Antibodies that bind egfr and cmet |
| JP2020530297A (ja) | 2017-08-11 | 2020-10-22 | ジェネンテック, インコーポレイテッド | 抗cd8抗体及びその使用 |
| US20200306516A1 (en) | 2017-08-14 | 2020-10-01 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with glatiramer or a pharmaceutically acceptable salt thereof |
| PE20200797A1 (es) | 2017-08-25 | 2020-08-10 | Five Prime Therapeutics Inc | Anticuerpos que se unen especificamente a b7-h4 humana |
| CN109422811A (zh) | 2017-08-29 | 2019-03-05 | 信达生物制药(苏州)有限公司 | 抗cd47抗体及其用途 |
| US20200216542A1 (en) | 2017-09-20 | 2020-07-09 | Chugai Seiyaku Kabushiki Kaisha | Dosage regimen for combination therapy using pd-1 axis binding antagonists and gpc3 targeting agent |
| AR113142A1 (es) | 2017-09-29 | 2020-01-29 | Chugai Pharmaceutical Co Ltd | Moléculas de unión al antígeno multiespecíficas que tienen actividad de sustitución de la función de cofactor del factor viii de coagulación de sangre (fviii), y formulaciones farmacéuticas que contienen dicha molécula como ingrediente activo |
| WO2019077500A1 (en) | 2017-10-16 | 2019-04-25 | Eisai R&D Management Co., Ltd. | ANTI-WATER ANTIBODIES AND USES THEREOF |
| BR112020007736A2 (pt) | 2017-10-30 | 2020-10-20 | F. Hoffmann-La Roche Ag | composição e método de tratamento |
| PL3704146T3 (pl) | 2017-11-01 | 2022-03-07 | F. Hoffmann-La Roche Ag | Przeciwciało Contorsbody trifab |
| JP2021500902A (ja) | 2017-11-01 | 2021-01-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 新規tnfファミリーリガンド三量体含有抗原結合分子 |
| JP2021500930A (ja) | 2017-11-01 | 2021-01-14 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Compボディ−多価標的結合物質 |
| BR112020007630A2 (pt) | 2017-11-01 | 2020-11-17 | F. Hoffmann-La Roche Ag | anticorpo biespecífico ox40, produto farmacêutico, composição farmacêutica e anticorpos biespecíficos anti-fap/ anti-ox40 |
| CA3076027A1 (en) | 2017-11-01 | 2019-05-09 | F. Hoffmann-La Roche Ag | Bispecific 2+1 contorsbodies |
| US12150990B2 (en) * | 2017-11-02 | 2024-11-26 | Nanjing Shunxin Pharmaceutical Co., Ltd. | Pharmaceutical composition of humanized monoclonal anti-PD-L1 antibody |
| CN111556895B (zh) | 2017-11-14 | 2024-09-13 | 中外制药株式会社 | 抗-c1s抗体及使用方法 |
| CN111356471A (zh) | 2017-11-20 | 2020-06-30 | 济世发展生物药业有限公司 | 包含赖氨酸盐作为张力调节剂的阿柏西普制剂及其用途 |
| WO2019103906A1 (en) | 2017-11-21 | 2019-05-31 | Forsight Vision4, Inc. | Fluid exchange apparatus for expandable port delivery system and methods of use |
| CA3083971A1 (en) * | 2017-11-30 | 2019-06-06 | Bio-Thera Solutions, Ltd. | Liquid formulation of humanized antibody for treating il-6 related diseases |
| EP3658192B1 (en) | 2017-12-01 | 2021-04-28 | AbbVie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
| EP3502140A1 (en) | 2017-12-21 | 2019-06-26 | F. Hoffmann-La Roche AG | Combination therapy of tumor targeted icos agonists with t-cell bispecific molecules |
| US20190211098A1 (en) | 2017-12-22 | 2019-07-11 | Genentech, Inc. | Use of pilra binding agents for treatment of a disease |
| WO2019129137A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗lag-3抗体及其用途 |
| CN109970857B (zh) | 2017-12-27 | 2022-09-30 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| WO2019129136A1 (zh) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | 抗pd-l1抗体及其用途 |
| JP7436365B2 (ja) | 2017-12-29 | 2024-02-21 | エフ. ホフマン-ラ ロシュ アーゲー | 抗vegf抗体及び使用の方法 |
| CN111886247A (zh) | 2018-01-05 | 2020-11-03 | Ac免疫有限公司 | 错折叠tdp-43结合分子 |
| WO2019139987A1 (en) | 2018-01-09 | 2019-07-18 | Elstar Therapeutics, Inc. | Calreticulin binding constructs and engineered t cells for the treatment of diseases |
| WO2019143636A1 (en) | 2018-01-16 | 2019-07-25 | Lakepharma, Inc. | Bispecific antibody that binds cd3 and another target |
| US20210031012A1 (en) | 2018-01-26 | 2021-02-04 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a pde4 inhibitor |
| MX2020007018A (es) | 2018-01-26 | 2020-09-07 | Genentech Inc | Proteinas de fusion fc il-22 y metodos de uso. |
| US11807663B2 (en) | 2018-02-01 | 2023-11-07 | Innovent Biologics (Suzhou) Co., Ltd. | Fully humanized anti-B cell maturation antigen (BCMA) single-chain antibody and use thereof |
| WO2019153200A1 (zh) | 2018-02-08 | 2019-08-15 | 北京韩美药品有限公司 | 抗pd-1/抗her2天然抗体结构样异源二聚体形式双特异抗体及其制备 |
| JP7350756B2 (ja) | 2018-02-14 | 2023-09-26 | アバ セラピューティクス アーゲー | 抗ヒトpd-l2抗体 |
| MX2020008502A (es) | 2018-02-21 | 2020-09-25 | Genentech Inc | Dosis para el tratamiento con proteinas de fusion il-22 fc. |
| BR112020016986A2 (pt) * | 2018-02-21 | 2021-03-02 | Five Prime Therapeutics, Inc. | formulações de anticorpo contra b7-h4 |
| MX2020008882A (es) | 2018-02-26 | 2021-01-08 | Genentech Inc | Dosificación para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1. |
| CA3091801A1 (en) | 2018-03-02 | 2019-09-06 | Five Prime Therapeutics, Inc. | B7-h4 antibodies and methods of use thereof |
| CN119074915A (zh) | 2018-03-13 | 2024-12-06 | 豪夫迈·罗氏有限公司 | 4-1bb激动剂与抗cd20抗体的治疗剂组合 |
| TWI841551B (zh) | 2018-03-13 | 2024-05-11 | 瑞士商赫孚孟拉羅股份公司 | 使用靶向4-1bb (cd137)之促效劑的組合療法 |
| US20200040103A1 (en) | 2018-03-14 | 2020-02-06 | Genentech, Inc. | Anti-klk5 antibodies and methods of use |
| US12152073B2 (en) | 2018-03-14 | 2024-11-26 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to calreticulin and uses thereof |
| KR20200132938A (ko) | 2018-03-15 | 2020-11-25 | 추가이 세이야쿠 가부시키가이샤 | 지카 바이러스에 대해 교차-반응성을 갖는 항-뎅기 바이러스 항체 및 사용 방법 |
| TWI841554B (zh) | 2018-03-21 | 2024-05-11 | 丹麥商珍美寶股份有限公司 | 以鉑為主之劑與抗組織因子抗體-藥物共軛物的組合治療癌症之方法 |
| WO2019192432A1 (zh) | 2018-04-02 | 2019-10-10 | 上海博威生物医药有限公司 | 结合淋巴细胞活化基因-3(lag-3)的抗体及其用途 |
| WO2019195313A1 (en) * | 2018-04-04 | 2019-10-10 | Pollack Aryeh L | Anti-vegf antagonist and pedf agonist constructs and uses thereof |
| SG11202009874QA (en) * | 2018-04-10 | 2020-11-27 | Dr Reddys Laboratories Ltd | Antibody formulation |
| CN111741979B (zh) | 2018-04-13 | 2024-07-02 | 豪夫迈·罗氏有限公司 | 包含4-1BBL的Her2靶向性抗原结合分子 |
| AR115052A1 (es) | 2018-04-18 | 2020-11-25 | Hoffmann La Roche | Anticuerpos multiespecíficos y utilización de los mismos |
| AR114789A1 (es) | 2018-04-18 | 2020-10-14 | Hoffmann La Roche | Anticuerpos anti-hla-g y uso de los mismos |
| EP3560945A1 (en) | 2018-04-27 | 2019-10-30 | F. Hoffmann-La Roche AG | Methods for purification of polypeptides using polysorbates |
| CA3099547A1 (en) | 2018-05-07 | 2019-11-14 | Reshma Abdulla RANGWALA | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| IL318714A (en) | 2018-05-10 | 2025-03-01 | Regeneron Pharma | Formulations that include high concentrations of VEGF receptor fusion protein |
| SG11202010469QA (en) | 2018-05-23 | 2020-11-27 | Adc Therapeutics Sa | Molecular adjuvant |
| WO2019232323A1 (en) * | 2018-05-31 | 2019-12-05 | Board Of Regents, The University Of Texas System | Bi-specific antibodies and use thereof |
| WO2019235426A1 (ja) | 2018-06-04 | 2019-12-12 | 中外製薬株式会社 | 細胞質内での半減期が変化した抗原結合分子 |
| WO2019246312A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246455A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an integrin inhibitor |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| EP3810095A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with a tnf inhibitor |
| US12171764B2 (en) | 2018-06-20 | 2024-12-24 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a JAK or other kinase inhibitor |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| MA52968A (fr) | 2018-06-23 | 2021-04-28 | Hoffmann La Roche | Méthodes de traitement du cancer du poumon à l'aide d'un antagoniste de liaison à l'axe pd-1, d'un agent de platine et d'un inhibiteur de la topoisomérase ii |
| CN112955465A (zh) | 2018-07-03 | 2021-06-11 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| TW202035447A (zh) | 2018-07-04 | 2020-10-01 | 瑞士商赫孚孟拉羅股份公司 | 新穎雙特異性促效性4-1bb抗原結合分子 |
| CN110732023B (zh) * | 2018-07-18 | 2023-06-16 | 江苏恒瑞医药股份有限公司 | 一种her2抗体药物组合物及其用途 |
| KR20210034622A (ko) | 2018-07-18 | 2021-03-30 | 제넨테크, 인크. | Pd-1 축 결합 길항제, 항 대사제, 및 백금 제제를 이용한 폐암 치료 방법 |
| US11730698B2 (en) | 2018-07-19 | 2023-08-22 | Celltrion Inc. | Stable liquid pharmaceutical preparation |
| EP3823673A4 (en) | 2018-07-20 | 2022-05-11 | Surface Oncology, Inc. | Anti-cd112r compositions and methods |
| KR20210040827A (ko) | 2018-07-25 | 2021-04-14 | 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 | 항 tigit 항체 및 그 용도 |
| WO2020027330A1 (ja) | 2018-08-03 | 2020-02-06 | 中外製薬株式会社 | 互いに連結された2つの抗原結合ドメインを含む抗原結合分子 |
| SG10202106830VA (en) | 2018-08-10 | 2021-08-30 | Chugai Pharmaceutical Co Ltd | Anti-cd137 antigen-binding molecule and utilization thereof |
| TW202021618A (zh) | 2018-08-17 | 2020-06-16 | 美商23與我有限公司 | 抗il1rap抗體及其使用方法 |
| CA3098765A1 (en) | 2018-09-21 | 2020-03-26 | Innovent Biologics (Suzhou) Co., Ltd. | Novel interleukin-2 and use thereof |
| CN112105633B (zh) | 2018-09-21 | 2024-03-12 | 信达生物制药(苏州)有限公司 | 新型白介素2及其用途 |
| PL3857230T3 (pl) | 2018-09-21 | 2023-10-16 | F. Hoffmann-La Roche Ag | Sposoby diagnostyczne dla potrójnie ujemnego raka piersi |
| JP2022511396A (ja) | 2018-10-01 | 2022-01-31 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Cd40への三価結合を伴う二重特異性抗原結合分子 |
| SG11202102477QA (en) | 2018-10-01 | 2021-04-29 | Hoffmann La Roche | Bispecific antigen binding molecules comprising anti-fap clone 212 |
| WO2020081493A1 (en) | 2018-10-16 | 2020-04-23 | Molecular Templates, Inc. | Pd-l1 binding proteins |
| MX2021004774A (es) * | 2018-10-29 | 2021-08-24 | Hoffmann La Roche | Formulacion de anticuerpos. |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法 |
| KR20210124959A (ko) * | 2018-11-06 | 2021-10-15 | 젠맵 에이/에스 | 항체 제제 |
| BR112021008873A8 (pt) | 2018-11-07 | 2023-04-11 | Merck Sharp & Dohme | Formulação |
| AU2019386021B2 (en) | 2018-11-27 | 2024-02-15 | Innovent Biologics (Suzhou) Co., Ltd. | Anti-il-23p19 antibody and uses thereof |
| AU2019394940A1 (en) | 2018-12-05 | 2021-06-24 | Genentech, Inc. | Diagnostic methods and compositions for cancer immunotherapy |
| KR20210100668A (ko) | 2018-12-06 | 2021-08-17 | 제넨테크, 인크. | 항-CD79b 면역접합체, 알킬화제 및 항-CD20 항체를 포함하는 미만성 큰 B-세포 림프종의 조합 요법 |
| MX2021007047A (es) * | 2018-12-14 | 2021-10-26 | Morphosys Ag | Formulaciones de anticuerpos. |
| KR20210106476A (ko) * | 2018-12-18 | 2021-08-30 | 노파르티스 아게 | 고농도의 항-vegf 항체를 함유하는 단백질 용액 제형 |
| CN113227131B (zh) | 2018-12-20 | 2025-03-04 | 豪夫迈·罗氏有限公司 | 经修饰的抗体Fc及其使用方法 |
| AR117327A1 (es) | 2018-12-20 | 2021-07-28 | 23Andme Inc | Anticuerpos anti-cd96 y métodos de uso de estos |
| AR123405A1 (es) | 2018-12-21 | 2022-11-30 | 23Andme Inc | Anticuerpos anti-il-36 y métodos de uso de estos |
| PE20211696A1 (es) | 2018-12-21 | 2021-09-01 | Hoffmann La Roche | Moleculas agonistas de union al antigeno cd28 que actuan sobre el tumor |
| CN113195531B (zh) | 2018-12-21 | 2025-03-04 | 豪夫迈·罗氏有限公司 | 与VEGF和IL-1β结合的抗体及其使用方法 |
| WO2020127628A1 (en) | 2018-12-21 | 2020-06-25 | F. Hoffmann-La Roche Ag | Tumor-targeted superagonistic cd28 antigen binding molecules |
| WO2020136060A1 (en) | 2018-12-28 | 2020-07-02 | F. Hoffmann-La Roche Ag | A peptide-mhc-i-antibody fusion protein for therapeutic use in a patient with amplified immune response |
| CN111375057B (zh) * | 2018-12-28 | 2024-06-21 | 上海复宏汉霖生物技术股份有限公司 | 一种包含抗Her2单克隆抗体的药物配制剂 |
| KR20210116525A (ko) | 2019-01-14 | 2021-09-27 | 제넨테크, 인크. | Pd-1 축 결합 길항제 및 rna 백신으로 암을 치료하는 방법 |
| CN113329763A (zh) | 2019-01-22 | 2021-08-31 | 豪夫迈·罗氏有限公司 | 免疫球蛋白a抗体以及制备和使用方法 |
| WO2020153467A1 (ja) | 2019-01-24 | 2020-07-30 | 中外製薬株式会社 | 新規がん抗原及びそれらの抗原に対する抗体 |
| TWI756621B (zh) | 2019-01-25 | 2022-03-01 | 大陸商信達生物製藥(蘇州)有限公司 | 新型雙特異性抗體分子以及同時結合pd-l1和lag-3的雙特異性抗體 |
| JP7266108B2 (ja) | 2019-02-18 | 2023-04-27 | イーライ リリー アンド カンパニー | 治療用抗体製剤 |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス,インコーポレーテッド | T細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| WO2020172605A1 (en) | 2019-02-21 | 2020-08-27 | Elstar Therapeutics, Inc. | Antibody molecules that bind to nkp30 and uses thereof |
| AU2020228383A1 (en) | 2019-02-27 | 2021-09-23 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-CD20 or anti-CD38 antibodies |
| CN111686247B (zh) * | 2019-03-13 | 2022-07-29 | 苏州康乃德生物医药有限公司 | 包含人白介素-4受体α的抗体的液体组合物 |
| JP7730761B2 (ja) | 2019-03-14 | 2025-08-28 | ジェネンテック, インコーポレイテッド | 抗HER2 MABと組み合わせたHER2xCD3二重特異性抗体によるがんの処置 |
| TWI861073B (zh) * | 2019-03-21 | 2024-11-11 | 美商再生元醫藥公司 | 含有抗il-33抗體之穩定調配物 |
| JP7301155B2 (ja) | 2019-04-12 | 2023-06-30 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | リポカリンムテインを含む二重特異性抗原結合分子 |
| CN114364703A (zh) | 2019-04-19 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 抗mertk抗体及它们的使用方法 |
| JP2022530674A (ja) | 2019-05-03 | 2022-06-30 | ジェネンテック, インコーポレイテッド | 抗pd-l1抗体を用いたがんの処置方法 |
| EP3963079A1 (en) * | 2019-05-03 | 2022-03-09 | Five Prime Therapeutics, Inc. | Pharmaceutical formulations containing cd80 extracellular domain-fc fusion proteins |
| KR20220007136A (ko) | 2019-05-14 | 2022-01-18 | 제넨테크, 인크. | 소포 림프종을 치료하기 위한 항-CD79b 면역접합체의 사용 방법 |
| JP2022533432A (ja) | 2019-05-23 | 2022-07-22 | エイシー イミューン ソシエテ アノニム | 抗tdp-43結合分子およびその使用 |
| CN116751295A (zh) | 2019-06-04 | 2023-09-15 | 江苏恒瑞医药股份有限公司 | 能结合胸腺基质淋巴细胞生成素的抗体及其应用 |
| WO2020260329A1 (en) | 2019-06-26 | 2020-12-30 | F. Hoffmann-La Roche Ag | Fusion of an antibody binding cea and 4-1bbl |
| JP7354306B2 (ja) | 2019-06-27 | 2023-10-02 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 新規icos抗体及びそれらを含む腫瘍標的化抗原結合分子 |
| MX2022000111A (es) | 2019-07-10 | 2022-02-10 | Chugai Pharmaceutical Co Ltd | Moleculas de union a claudina-6 y usos de las mismas. |
| AR119382A1 (es) | 2019-07-12 | 2021-12-15 | Hoffmann La Roche | Anticuerpos de pre-direccionamiento y métodos de uso |
| CN112805566A (zh) * | 2019-07-29 | 2021-05-14 | 上海谷森医药有限公司 | 用于吸入治疗肺癌的抗体类药物制剂 |
| NZ785788A (en) * | 2019-08-29 | 2025-09-26 | Vir Biotechnology Inc | Antibody compositions and methods for treating hepatitis b virus infection |
| WO2021041878A1 (en) * | 2019-08-30 | 2021-03-04 | Dragonfly Therapeutics, Inc. | Pharmaceutical formulations and dosage regimens for multi-specific binding proteins that bind her2, nkg2d, and cd16 for cancer treatment |
| EP4025608A1 (en) | 2019-09-04 | 2022-07-13 | F. Hoffmann-La Roche AG | Cd8 binding agents and uses thereof |
| KR20220064980A (ko) | 2019-09-18 | 2022-05-19 | 제넨테크, 인크. | 항 klk7 항체, 항 klk5 항체, 다중특이적 항 klk5/klk7 항체, 및 사용 방법 |
| WO2021062085A1 (en) | 2019-09-27 | 2021-04-01 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| EP4025250A4 (en) * | 2019-10-12 | 2024-01-17 | Bio-Thera Solutions, Ltd. | FORMULATION OF ANTI-CD20 ANTIBODIES AND USE OF ANTI-CD20 ANTIBODIES FOR THE TREATMENT OF CD20-POSITIVE DISEASES |
| KR20220086618A (ko) | 2019-10-18 | 2022-06-23 | 제넨테크, 인크. | 미만성 거대 B-세포 림프종을 치료하기 위한 항-CD79b 면역접합체의 사용 방법 |
| CN118178645A (zh) | 2019-10-18 | 2024-06-14 | 四十七公司 | 用于治疗骨髓增生异常综合征和急性髓系白血病的联合疗法 |
| WO2021079337A1 (en) * | 2019-10-23 | 2021-04-29 | Cadila Healthcare Limited | Pharmaceutical formulation of anti-her2 antibody and preparation thereof |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| EP4055388A1 (en) | 2019-11-06 | 2022-09-14 | Genentech, Inc. | Diagnostic and therapeutic methods for treatment of hematologic cancers |
| CN114786717B (zh) * | 2019-11-13 | 2024-12-17 | 辉瑞公司 | 稳定的水性抗-tfpi抗体制剂 |
| CA3158243A1 (en) * | 2019-11-15 | 2021-07-15 | Brian D. Lawrence | Stable formulations of silk-derived protein |
| CN114786721B (zh) * | 2019-12-06 | 2025-10-17 | 康诺贝林伦瑙有限公司 | Fc多聚体的稳定组合物 |
| US11845799B2 (en) | 2019-12-13 | 2023-12-19 | Genentech, Inc. | Anti-Ly6G6D antibodies and methods of use |
| CU20190104A7 (es) * | 2019-12-17 | 2021-08-06 | Ct Inmunologia Molecular | Formulación estable del anticuerpo nimotuzumab |
| CN114867532A (zh) | 2019-12-18 | 2022-08-05 | 豪夫迈·罗氏有限公司 | 双特异性抗ccl2抗体 |
| CA3162444C (en) | 2019-12-27 | 2024-04-30 | Hitoshi KATADA | Anti-ctla-4 antibody and use thereof |
| CA3166629A1 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| MX2022008214A (es) | 2020-01-09 | 2022-08-08 | Hoffmann La Roche | Nuevas moleculas de union al antigeno que contienen el trimero de 4-1bbl. |
| CN110818795B (zh) | 2020-01-10 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | 抗tigit抗体和使用方法 |
| CA3168600A1 (en) * | 2020-01-21 | 2021-07-29 | Innovent Biologics (Suzhou) Co., Ltd. | Recombinant fully human anti-tigit monoclonal antibody formulation, method for preparing same and use thereof |
| WO2021194481A1 (en) | 2020-03-24 | 2021-09-30 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| WO2022050954A1 (en) | 2020-09-04 | 2022-03-10 | Genentech, Inc. | Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies |
| JP2023512654A (ja) | 2020-01-31 | 2023-03-28 | ジェネンテック, インコーポレイテッド | Pd-1軸結合アンタゴニストおよびrnaワクチンを用いてネオエピトープ特異的t細胞を誘導する方法 |
| AU2021220887B2 (en) | 2020-02-10 | 2024-11-21 | Shanghai Escugen Biotechnology Co., Ltd. | CLDN18.2 antibody and use thereof |
| US20230096452A1 (en) | 2020-02-10 | 2023-03-30 | Shanghai Escugen Biotechnology Co., Ltd. | Claudin 18.2 antibody and use thereof |
| TWI895351B (zh) | 2020-02-12 | 2025-09-01 | 日商中外製藥股份有限公司 | 用於癌症之治療的抗cd137抗原結合分子 |
| AU2021232369B2 (en) * | 2020-03-04 | 2025-06-05 | Shanghai Henlius Biotech, Inc. | Pharmaceutical formulation comprising bevacizumab |
| WO2021177980A1 (en) | 2020-03-06 | 2021-09-10 | Genentech, Inc. | Combination therapy for cancer comprising pd-1 axis binding antagonist and il6 antagonist |
| WO2021181317A1 (en) * | 2020-03-11 | 2021-09-16 | Lupin Limited | Monoclonal antibody pharmaceutical composition |
| EP4118114A1 (en) | 2020-03-13 | 2023-01-18 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| EP4121163A1 (en) | 2020-03-19 | 2023-01-25 | Genentech, Inc. | Isoform-selective anti-tgf-beta antibodies and methods of use |
| CN115315437B (zh) | 2020-03-19 | 2025-10-17 | 信达生物制药(苏州)有限公司 | 白介素2突变体及其用途 |
| EP4126949A1 (en) | 2020-03-24 | 2023-02-08 | Genentech, Inc. | Tie2-binding agents and methods of use |
| EP4126940A1 (en) | 2020-03-30 | 2023-02-08 | F. Hoffmann-La Roche AG | Antibody that binds to vegf and pdgf-b and methods of use |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| WO2021207662A1 (en) | 2020-04-10 | 2021-10-14 | Genentech, Inc. | Use of il-22fc for the treatment or prevention of pneumonia, acute respiratory distress syndrome, or cytokine release syndrome |
| US20230242657A1 (en) | 2020-04-17 | 2023-08-03 | Hutchison Medipharma Limited | Anti-ox40 antibody and uses thereof |
| CN115916822A (zh) | 2020-04-24 | 2023-04-04 | 基因泰克公司 | 使用抗CD79b免疫缀合物的方法 |
| JP2023523450A (ja) | 2020-04-28 | 2023-06-05 | ジェネンテック, インコーポレイテッド | 非小細胞肺がん免疫療法のための方法及び組成物 |
| CN116963782A (zh) | 2020-05-03 | 2023-10-27 | 联宁(苏州)生物制药有限公司 | 包含抗trop-2抗体的抗体药物偶联物 |
| US20230227917A1 (en) | 2020-05-05 | 2023-07-20 | Hoffmann-La Roche Inc. | Predicting response to pd-1 axis inhibitors |
| US20230173069A1 (en) * | 2020-05-13 | 2023-06-08 | Innovent Biologics (Suzhou) Co., Ltd. | Formulation comprising anti-il-23p19 antibody, method for preparing same and use thereof |
| CN116323665A (zh) | 2020-05-29 | 2023-06-23 | 23和我公司 | 抗cd200r1抗体及其使用方法 |
| IL298599A (en) | 2020-06-01 | 2023-01-01 | Genentech Inc | Methods for preparing extracellular vesicles and their uses |
| CN115697489A (zh) | 2020-06-08 | 2023-02-03 | 豪夫迈·罗氏有限公司 | 抗hbv抗体及其使用方法 |
| CN113769082A (zh) * | 2020-06-10 | 2021-12-10 | 上海君实生物医药科技股份有限公司 | 抗il-17a抗体药物组合物及其用途 |
| EP4165415A1 (en) | 2020-06-12 | 2023-04-19 | Genentech, Inc. | Methods and compositions for cancer immunotherapy |
| FI129383B (en) * | 2020-06-15 | 2022-01-31 | Faron Pharmaceuticals Oy | STABLE ANTI-CLEVER-1 ANTIBODY FORMULATION |
| EP4164627A1 (en) | 2020-06-16 | 2023-04-19 | Genentech, Inc. | Methods and compositions for treating triple-negative breast cancer |
| US20210395366A1 (en) | 2020-06-18 | 2021-12-23 | Genentech, Inc. | Treatment with anti-tigit antibodies and pd-1 axis binding antagonists |
| JP2023531222A (ja) | 2020-06-22 | 2023-07-21 | アルミラル・ソシエダッド・アノニマ | 抗il-36抗体およびその使用方法 |
| CR20220627A (es) | 2020-06-23 | 2023-02-17 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se derigen a her2 |
| JP2023531067A (ja) | 2020-06-25 | 2023-07-20 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 抗cd3/抗cd28二重特異性抗原結合分子 |
| BR112022026780A2 (pt) * | 2020-06-29 | 2023-01-17 | Hanall Biopharma Co Ltd | Formulação para anticorpo anti-fcrn |
| MX2022015884A (es) | 2020-06-29 | 2023-04-03 | Genentech Inc | Combinacion de dosis fija de pertuzumab mas trastuzumab. |
| PE20230434A1 (es) | 2020-07-10 | 2023-03-08 | Hoffmann La Roche | Anticuerpos que se unen a celulas cancerosas y dirigen radionucleotidos a dichas celulas |
| CN116406377A (zh) | 2020-07-17 | 2023-07-07 | 基因泰克公司 | 抗notch2抗体及其使用方法 |
| CN116568824A (zh) | 2020-08-03 | 2023-08-08 | 基因泰克公司 | 淋巴瘤的诊断和治疗方法 |
| US20230322908A1 (en) | 2020-08-14 | 2023-10-12 | Ac Immune Sa | Humanized Anti-TDP-43 Binding Molecules and Uses Thereof |
| CA3190803A1 (en) | 2020-08-14 | 2022-02-17 | F. Hoffmann-La Roche Ag | Methods for treating multiple sclerosis with ocrelizumab |
| WO2022043517A2 (en) | 2020-08-27 | 2022-03-03 | Cureab Gmbh | Anti-golph2 antibodies for macrophage and dendritic cell differentiation |
| KR20230061458A (ko) | 2020-09-04 | 2023-05-08 | 에프. 호프만-라 로슈 아게 | Vegf-a 및 ang2에 결합하는 항체 및 사용 방법 |
| JP2023541627A (ja) | 2020-09-14 | 2023-10-03 | イシュノス サイエンシズ ソシエテ アノニム | Il1rapに結合する抗体及びその使用 |
| CA3193952A1 (en) | 2020-10-05 | 2022-04-14 | Bernard Martin Fine | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| KR20230091871A (ko) | 2020-10-20 | 2023-06-23 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항제 및 lrrk2 억제제의 병용 요법 |
| EP4232475A1 (en) | 2020-10-20 | 2023-08-30 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments specifically binding to gremlin-1 and uses thereof |
| AR123855A1 (es) | 2020-10-20 | 2023-01-18 | Genentech Inc | Anticuerpos anti-mertk conjugados con peg y métodos de uso |
| CN116782929A (zh) | 2020-11-02 | 2023-09-19 | Ucb生物制药有限责任公司 | 抗-trem1中和抗体用于治疗运动神经元变性病症的用途 |
| CA3196191A1 (en) | 2020-11-04 | 2022-05-12 | Chi-Chung Li | Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies and anti-cd79b antibody drug conjugates |
| JP7402381B2 (ja) | 2020-11-04 | 2023-12-20 | ジェネンテック, インコーポレイテッド | 抗cd20/抗cd3二重特異性抗体による処置のための投与 |
| EP4240766A2 (en) | 2020-11-04 | 2023-09-13 | Genentech, Inc. | Subcutaneous dosing of anti-cd20/anti-cd3 bispecific antibodies |
| WO2022101458A1 (en) | 2020-11-16 | 2022-05-19 | F. Hoffmann-La Roche Ag | Combination therapy with fap-targeted cd40 agonists |
| CA3200767A1 (en) * | 2020-12-03 | 2022-06-09 | Zhiwan WANG | Anti-tslp antibody pharmaceutical composition and use thereof |
| IL303295A (en) | 2020-12-07 | 2023-07-01 | UCB Biopharma SRL | Multi-specific antibodies and antibody combinations |
| EP4255925A1 (en) | 2020-12-07 | 2023-10-11 | UCB Biopharma SRL | Antibodies against interleukin-22 |
| EP4065161A4 (en) * | 2020-12-14 | 2025-07-30 | Ammax Bio Inc | HIGH CONCENTRATION FORMULATIONS OF ANTI-CSF1 AND ANTI-CSF1R ANTIBODIES |
| CA3204702A1 (en) | 2020-12-17 | 2022-06-23 | F. Hoffmann-La Roche Ag | Anti-hla-g antibodies and use thereof |
| EP4271710A1 (en) | 2020-12-29 | 2023-11-08 | CeMM - Forschungszentrum für Molekulare Medizin GmbH | Anti-april antibodies and uses thereof |
| IL304067A (en) | 2021-01-06 | 2023-08-01 | Hoffmann La Roche | Combined treatment using PD1-LAG3 bispecific antibody and CD20 T cell bispecific antibody |
| KR20230131204A (ko) | 2021-01-12 | 2023-09-12 | 에프. 호프만-라 로슈 아게 | 암 세포에 결합하여 방사성핵종을 상기 세포에 표적화하는분할 항체 |
| WO2022152701A1 (en) | 2021-01-13 | 2022-07-21 | F. Hoffmann-La Roche Ag | Combination therapy |
| WO2022162587A1 (en) | 2021-01-27 | 2022-08-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| CN117120084A (zh) | 2021-01-28 | 2023-11-24 | 维肯芬特有限责任公司 | 用于调节b细胞介导的免疫应答的方法和手段 |
| WO2022162203A1 (en) | 2021-01-28 | 2022-08-04 | Vaccinvent Gmbh | Method and means for modulating b-cell mediated immune responses |
| JP2024509695A (ja) | 2021-02-03 | 2024-03-05 | ジェネンテック, インコーポレイテッド | 多重特異性結合タンパク質分解プラットフォームおよび使用方法 |
| GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
| CN117062839A (zh) | 2021-03-12 | 2023-11-14 | 基因泰克公司 | 抗klk7抗体、抗klk5抗体、多特异性抗klk5/klk7抗体和使用方法 |
| AR125344A1 (es) | 2021-04-15 | 2023-07-05 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-c1s |
| CN117396232A (zh) | 2021-05-12 | 2024-01-12 | 基因泰克公司 | 使用抗cd79b免疫缀合物治疗弥漫性大b细胞淋巴瘤的方法 |
| JP2023546368A (ja) | 2021-05-14 | 2023-11-02 | ジェネンテック, インコーポレイテッド | モスネツズマブおよびポラツズマブベドチンを用いたcd20陽性増殖性障害の処置のための方法 |
| AR126009A1 (es) | 2021-06-02 | 2023-08-30 | Hoffmann La Roche | Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam |
| WO2022255440A1 (en) | 2021-06-04 | 2022-12-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-ddr2 antibodies and uses thereof |
| AU2022289684A1 (en) | 2021-06-09 | 2023-10-05 | F. Hoffmann-La Roche Ag | Combination of a particular braf inhibitor (paradox breaker) and a pd-1 axis binding antagonist for use in the treatment of cancer |
| WO2022263638A1 (en) | 2021-06-17 | 2022-12-22 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| CN117500829A (zh) | 2021-06-18 | 2024-02-02 | 豪夫迈·罗氏有限公司 | 双特异性抗ccl2抗体 |
| CN119838007A (zh) | 2021-06-25 | 2025-04-18 | 中外制药株式会社 | 抗ctla-4抗体的用途 |
| WO2022270611A1 (ja) | 2021-06-25 | 2022-12-29 | 中外製薬株式会社 | 抗ctla-4抗体 |
| MX2023015416A (es) | 2021-07-02 | 2024-04-30 | Genentech Inc | Procedimientos y composiciones para tratar el cancer. |
| EP4373859A1 (en) | 2021-07-22 | 2024-05-29 | F. Hoffmann-La Roche AG | Heterodimeric fc domain antibodies |
| AU2022317820A1 (en) | 2021-07-28 | 2023-12-14 | F. Hoffmann-La Roche Ag | Methods and compositions for treating cancer |
| WO2023012147A1 (en) | 2021-08-03 | 2023-02-09 | F. Hoffmann-La Roche Ag | Bispecific antibodies and methods of use |
| US20240336697A1 (en) | 2021-08-07 | 2024-10-10 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates to treat diffuse large b-cell lymphoma |
| JP2024534151A (ja) | 2021-08-27 | 2024-09-18 | ジェネンテック, インコーポレイテッド | タウ病態の治療方法 |
| EP4396223A1 (en) | 2021-08-30 | 2024-07-10 | Genentech, Inc. | Anti-polyubiquitin multispecific antibodies |
| WO2023053282A1 (ja) | 2021-09-29 | 2023-04-06 | 中外製薬株式会社 | がんの治療に用いるための細胞傷害誘導治療剤 |
| TW202321308A (zh) | 2021-09-30 | 2023-06-01 | 美商建南德克公司 | 使用抗tigit抗體、抗cd38抗體及pd—1軸結合拮抗劑治療血液癌症的方法 |
| WO2023057404A1 (en) | 2021-10-06 | 2023-04-13 | F. Hoffmann-La Roche Ag | Novel combined administration |
| EP4413998A1 (en) | 2021-10-08 | 2024-08-14 | Chugai Seiyaku Kabushiki Kaisha | Method for preparing prefilled syringe formulation |
| EP4422683A4 (en) * | 2021-10-29 | 2025-07-30 | Nascent Biotech Inc | KITS AND CONTAINERS FOR THE TREATMENT OF VIMENTIN-EXPRESSING TUMORS |
| EP4426727A2 (en) | 2021-11-03 | 2024-09-11 | Hangzhou Dac Biotech Co., Ltd. | Specific conjugation of an antibody |
| JP2024540374A (ja) | 2021-11-05 | 2024-10-31 | アメリカン ダイアグノスティックス アンド セラピー, エルエルシー (エーディーエックスアールエックス) | がん胎児性抗原に対するモノクローナル抗体、及びそれらの使用 |
| WO2023086807A1 (en) | 2021-11-10 | 2023-05-19 | Genentech, Inc. | Anti-interleukin-33 antibodies and uses thereof |
| MX2024005876A (es) | 2021-11-16 | 2024-05-29 | Ac Immune Sa | Moleculas novedosas para terapias y diagnostico. |
| CA3236006A1 (en) | 2021-11-16 | 2023-05-25 | Genentech, Inc. | Methods and compositions for treating systemic lupus erythematosus (sle) with mosunetuzumab |
| US20250025410A1 (en) * | 2021-11-30 | 2025-01-23 | Enzene Biosciences Limited | Composition comprising her2 antibody, formulation and process of preparation thereof |
| JP2025501522A (ja) | 2021-12-17 | 2025-01-22 | シャンハイ・ヘンリウス・バイオテック・インコーポレイテッド | 抗ox40抗体及び使用方法 |
| WO2023109900A1 (en) | 2021-12-17 | 2023-06-22 | Shanghai Henlius Biotech, Inc. | Anti-ox40 antibodies, multispecific antibodies and methods of use |
| TW202340251A (zh) | 2022-01-19 | 2023-10-16 | 美商建南德克公司 | 抗notch2抗體及結合物及其使用方法 |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
| AU2023221539A1 (en) | 2022-02-16 | 2024-08-22 | Ac Immune Sa | Humanized anti-tdp-43 binding molecules and uses thereof |
| AU2023240941A1 (en) | 2022-03-25 | 2024-09-19 | Shanghai Henlius Biologics Co., Ltd. | Anti-msln antibodies and methods of use |
| CN119053619A (zh) | 2022-04-01 | 2024-11-29 | 豪夫迈·罗氏有限公司 | 用于面肩肱型肌营养不良症(fshd)的新治疗 |
| EP4504780A1 (en) | 2022-04-01 | 2025-02-12 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| KR20250004705A (ko) | 2022-04-08 | 2025-01-08 | 에이씨 이뮨 에스에이 | 항-tdp-43 결합 분자 |
| EP4508086A1 (en) * | 2022-04-13 | 2025-02-19 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| JP2025512342A (ja) | 2022-04-13 | 2025-04-17 | ジェネンテック, インコーポレイテッド | 治療用タンパク質の医薬組成物および使用方法 |
| EP4511395A1 (en) | 2022-04-20 | 2025-02-26 | Kantonsspital St. Gallen | Antibodies or antigen-binding fragments pan-specifically binding to gremlin-1 and gremlin-2 and uses thereof |
| AU2023257490A1 (en) * | 2022-04-22 | 2024-10-31 | Eirgenix, Inc. | Pharmaceutical compositons containing anti-her2 antibody for subcutaneous administration |
| KR20250006932A (ko) | 2022-05-03 | 2025-01-13 | 제넨테크, 인크. | 항-Ly6E 항체, 면역접합체 및 이들의 용도 |
| WO2023219613A1 (en) | 2022-05-11 | 2023-11-16 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| AR129268A1 (es) | 2022-05-11 | 2024-08-07 | Hoffmann La Roche | Anticuerpo que se une a vegf-a e il6 y métodos de uso |
| WO2023237706A2 (en) | 2022-06-08 | 2023-12-14 | Institute For Research In Biomedicine (Irb) | Cross-specific antibodies, uses and methods for discovery thereof |
| WO2023250367A1 (en) | 2022-06-22 | 2023-12-28 | Genentech, Inc. | Methods for treatment of previously untreated follicular lymphoma with mosunetuzumab and lenalidomide |
| EP4554978A1 (en) | 2022-07-13 | 2025-05-21 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| TW202409078A (zh) * | 2022-07-18 | 2024-03-01 | 中國大陸商蘇州創勝醫藥集團有限公司 | 穩定之包含抗gremlin1抗體的藥物製劑 |
| JP2025523845A (ja) | 2022-07-19 | 2025-07-25 | ジェネンテック, インコーポレイテッド | 抗fcrh5/抗cd3二重特異性抗体による処置のための投薬 |
| CN119654349A (zh) | 2022-07-22 | 2025-03-18 | 基因泰克公司 | 抗steap1抗原结合分子及其用途 |
| US11773160B1 (en) | 2022-08-05 | 2023-10-03 | Anaveon AG | Immune-stimulating IL-2 fusion proteins |
| CA3265385A1 (en) | 2022-08-22 | 2024-02-29 | Abdera Therapeutics Inc. | DLL3 BINDING MOLECULES AND THEIR USES |
| WO2024044675A1 (en) | 2022-08-25 | 2024-02-29 | Beigene, Ltd. | Methods of cancer treatment using anti-pd1 antibodies in combination with anti-tim3 antibodies |
| CN115440385B (zh) * | 2022-08-30 | 2025-09-16 | 南京邮电大学 | 一种基于医疗场景的模糊高效用模式挖掘方法 |
| CN120153254A (zh) | 2022-09-01 | 2025-06-13 | 基因泰克公司 | 膀胱癌的治疗和诊断方法 |
| WO2024068996A1 (en) | 2022-09-30 | 2024-04-04 | Centre Hospitalier Universitaire Vaudois (C.H.U.V.) | Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection |
| AU2023367741A1 (en) | 2022-10-25 | 2025-05-01 | Genentech, Inc. | Therapeutic and diagnostic methods for multiple myeloma |
| IL320220A (en) | 2022-11-09 | 2025-06-01 | Cis Biopharma Ag | Antibodies against L1-CAM and their uses for diagnostic and therapeutic applications |
| WO2024103860A1 (zh) | 2022-11-18 | 2024-05-23 | 南京诺艾新生物技术有限公司 | 受体亲和力偏好性的定点偶联聚乙二醇化白介素-2突变体及其用途 |
| KR20250111207A (ko) | 2022-11-24 | 2025-07-22 | 비원 메디슨즈 아이 게엠베하 | 항체 약물 접합체 |
| TW202436348A (zh) | 2022-11-25 | 2024-09-16 | 日商中外製藥股份有限公司 | 蛋白質的製造方法 |
| CN119546630A (zh) | 2022-12-08 | 2025-02-28 | 南京诺唯赞生物科技股份有限公司 | 特异性结合rsv的抗体 |
| EP4634172A1 (en) | 2022-12-15 | 2025-10-22 | F. Hoffmann-La Roche AG | Combination therapy for cancer treatment |
| CN120435311A (zh) | 2022-12-20 | 2025-08-05 | 基因泰克公司 | 用pd-1轴结合拮抗剂和rna疫苗治疗胰腺癌的方法 |
| TW202434307A (zh) | 2023-01-18 | 2024-09-01 | 大陸商泰勵生物科技(上海)有限公司 | 抗體偶聯藥物及其用途 |
| WO2024163009A1 (en) | 2023-01-31 | 2024-08-08 | Genentech, Inc. | Methods and compositions for treating urothelial bladder cancer |
| TW202436339A (zh) | 2023-01-31 | 2024-09-16 | 瑞士商赫孚孟拉羅股份公司 | 治療選自非小細胞肺癌或三陰性乳癌的癌症之用途 |
| KR20250145079A (ko) | 2023-02-09 | 2025-10-13 | 비원 메디슨즈 아이 게엠베하 | 자가 안정화 링커 접합체 |
| TW202436357A (zh) | 2023-03-03 | 2024-09-16 | 瑞士商百濟神州瑞士有限責任公司 | Muc1抗體及使用方法 |
| CN120813603A (zh) | 2023-03-03 | 2025-10-17 | 广州百济神州生物制药有限公司 | Cd16a抗体和使用方法 |
| TW202436343A (zh) | 2023-03-03 | 2024-09-16 | 瑞士商百濟神州瑞士有限責任公司 | Muc1與cd16a抗體以及其使用方法 |
| WO2024184811A1 (en) | 2023-03-06 | 2024-09-12 | Beigene Switzerland Gmbh | Anti-cd3 multispecific antibodies and methods of use |
| AR132063A1 (es) | 2023-03-06 | 2025-05-21 | Beigene Switzerland Gmbh | Anticuerpos multiespecíficos anti-cldn6 y anti-cd3 y métodos de uso |
| TW202436354A (zh) | 2023-03-06 | 2024-09-16 | 瑞士商百濟神州瑞士有限責任公司 | 抗cldn6抗體以及其使用方法 |
| WO2024184494A1 (en) | 2023-03-08 | 2024-09-12 | Ac Immune Sa | Anti-tdp-43 binding molecules and uses thereof |
| WO2024188965A1 (en) | 2023-03-13 | 2024-09-19 | F. Hoffmann-La Roche Ag | Combination therapy employing a pd1-lag3 bispecific antibody and an hla-g t cell bispecific antibody |
| CN120957753A (zh) | 2023-03-23 | 2025-11-14 | 广州百济神州生物制药有限公司 | 生物活性结合物、其制备方法和其用途 |
| WO2024212827A1 (en) | 2023-04-12 | 2024-10-17 | Shanghai Kangabio Co., Limited | Multifunctional molecules comprising masked interleukin 12 and methods of use |
| CN120936604A (zh) | 2023-04-13 | 2025-11-11 | 广州百济神州生物制药有限公司 | 靶向吡咯并苯并二氮杂䓬缀合物 |
| AU2024270495A1 (en) | 2023-05-05 | 2025-10-09 | Genentech, Inc. | Dosing for treatment with anti-fcrh5/anti-cd3 bispecific antibodies |
| WO2024231320A1 (en) | 2023-05-08 | 2024-11-14 | F. Hoffmann-La Roche Ag | Targeted interferon alpha fusion proteins and methods of use |
| WO2024246083A1 (en) | 2023-06-01 | 2024-12-05 | F. Hoffmann-La Roche Ag | Bispecific antibodies targeting bcma and cd28 |
| CN121219321A (zh) | 2023-06-01 | 2025-12-26 | 豪夫迈·罗氏有限公司 | 与bcma特异性结合的免疫刺激性抗原结合分子 |
| TW202504641A (zh) | 2023-06-08 | 2025-02-01 | 美商建南德克公司 | 用於淋巴瘤之診斷及治療方法的巨噬細胞特徵 |
| TW202504929A (zh) | 2023-06-22 | 2025-02-01 | 美商建南德克公司 | 用於癌症治療之方法及組成物 |
| WO2024263195A1 (en) | 2023-06-23 | 2024-12-26 | Genentech, Inc. | Methods for treatment of liver cancer |
| WO2024263904A1 (en) | 2023-06-23 | 2024-12-26 | Genentech, Inc. | Methods for treatment of liver cancer |
| AU2024287304A1 (en) | 2023-07-11 | 2025-12-04 | F. Hoffmann-La Roche Ag | Compositions and methods for treating multiple sclerosis |
| WO2025032070A1 (en) | 2023-08-09 | 2025-02-13 | F. Hoffmann-La Roche Ag | Anti-a-beta protein antibodies, methods and uses thereof |
| WO2025037336A1 (en) * | 2023-08-12 | 2025-02-20 | Dr. Reddy's Laboratories Limited | Pharmaceutical formulations of anti-cd 20 antibody and methods of preparing the same |
| TW202515614A (zh) | 2023-08-25 | 2025-04-16 | 美商建南德克公司 | 治療非小細胞肺癌之方法及組成物 |
| TW202511497A (zh) | 2023-09-01 | 2025-03-16 | 瑞士商百濟神州瑞士有限責任公司 | 免疫相關基因表現特徵及其相關方法 |
| TW202515903A (zh) | 2023-10-12 | 2025-04-16 | 瑞士商百濟神州瑞士有限責任公司 | 手術前後基於抗pd-1之治療 |
| WO2025106474A1 (en) | 2023-11-14 | 2025-05-22 | Genentech, Inc. | Therapeutic and diagnostic methods for treating cancer with anti-fcrh5/anti-cd3 bispecific antibodies |
| WO2025117848A1 (en) | 2023-12-01 | 2025-06-05 | Genentech, Inc. | Low-viscosity variants of antibodies |
| WO2025133042A2 (en) | 2023-12-22 | 2025-06-26 | F. Hoffmann-La Roche Ag | Activatable fusion proteins and methods of use |
| WO2025155602A1 (en) | 2024-01-16 | 2025-07-24 | Genentech, Inc. | Method of treating hemophilia a |
| WO2025155607A1 (en) | 2024-01-16 | 2025-07-24 | Genentech, Inc. | Methods of treating urothelial carcinoma with a pd-1 axis binding antagonist and an rna vaccine |
| WO2025174933A1 (en) | 2024-02-14 | 2025-08-21 | Genentech, Inc. | Methods for treatment of pancreatic cancer with anti-pd-l1 ab, anti-tigit ab, gemcitabine and nab-placlitaxel |
| WO2025176733A1 (en) | 2024-02-19 | 2025-08-28 | Université De Genève | Antibody-drug conjugates involving small molecule atr/chk1 inhibitors |
| WO2025238187A1 (en) | 2024-05-15 | 2025-11-20 | Cis Biopharma Ag | Immunoconjugates targeting l1-cam |
| WO2025238133A1 (en) | 2024-05-17 | 2025-11-20 | UCB Biopharma SRL | Multispecific antibody with binding specificity for il-11 and il-17 |
| WO2025238135A2 (en) | 2024-05-17 | 2025-11-20 | UCB Biopharma SRL | Antibody with binding specificity for il-11 |
| WO2025242909A1 (en) | 2024-05-24 | 2025-11-27 | Paul Scherrer Institut | CD30-targeting antibody-radioligand conjugates and their therapeutic use |
| WO2025250969A1 (en) | 2024-05-31 | 2025-12-04 | Vertex Pharmaceuticals Incorporated | Anti-cd74 antibodies, conjugates and uses thereof |
| CN119950703B (zh) * | 2024-07-08 | 2025-10-28 | 武汉友芝友生物制药股份有限公司 | 抗体制剂 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003105894A1 (en) * | 2002-06-14 | 2003-12-24 | Medimmune, Inc. | Stabilized liquid anti-rsv antibody formulations |
Family Cites Families (254)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4515893A (en) | 1979-04-26 | 1985-05-07 | Ortho Pharmaceutical Corporation | Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4933294A (en) | 1984-01-30 | 1990-06-12 | Icrf Patents Limited | Method of detecting truncated epidermal growth factor receptors |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5091178A (en) | 1986-02-21 | 1992-02-25 | Oncogen | Tumor therapy with biologically active anti-tumor antibodies |
| US5401638A (en) | 1986-06-04 | 1995-03-28 | Oncogene Science, Inc. | Detection and quantification of neu related proteins in the biological fluids of humans |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US4968603A (en) * | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5824311A (en) * | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US5091313A (en) | 1988-08-05 | 1992-02-25 | Tanox Biosystems, Inc. | Antigenic epitopes of IgE present on B cell but not basophil surface |
| US5720937A (en) * | 1988-01-12 | 1998-02-24 | Genentech, Inc. | In vivo tumor detection assay |
| WO1989006692A1 (en) * | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| JP2749167B2 (ja) | 1988-06-21 | 1998-05-13 | ジェネンテク,インコーポレイテッド | 心筋梗塞の処置のための方法および治療用組成物 |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| AU4803890A (en) * | 1988-12-15 | 1990-07-10 | Invitron Corporation | Use of basic amino acids to solubilize immunoglobulins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| EP0474727B1 (en) | 1989-05-19 | 1997-07-23 | Genentech, Inc. | Her2 extracellular domain |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| AU641673B2 (en) | 1989-06-29 | 1993-09-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| WO1991003489A1 (en) | 1989-09-08 | 1991-03-21 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| WO1991005264A1 (en) | 1989-09-29 | 1991-04-18 | Oncogenetics Partners | Detection and quantification of neu related proteins in the biological fluids of humans |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5183884A (en) * | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| JPH06507398A (ja) | 1991-05-14 | 1994-08-25 | リプリジェン コーポレーション | Hiv感染治療のための異種複合抗体 |
| IL101943A0 (en) | 1991-05-24 | 1992-12-30 | Genentech Inc | Structure,production and use of heregulin |
| US6800738B1 (en) * | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
| WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| DE122004000008I1 (de) * | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
| US5264586A (en) | 1991-07-17 | 1993-11-23 | The Scripps Research Institute | Analogs of calicheamicin gamma1I, method of making and using the same |
| AU2498192A (en) | 1991-08-14 | 1993-03-16 | Genentech Inc. | Immunoglobulin variants for specific fc epsilon receptors |
| WO1993006217A1 (en) | 1991-09-19 | 1993-04-01 | Genentech, Inc. | EXPRESSION IN E. COLI OF ANTIBODY FRAGMENTS HAVING AT LEAST A CYSTEINE PRESENT AS A FREE THIOL, USE FOR THE PRODUCTION OF BIFUNCTIONAL F(ab')2 ANTIBODIES |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| EP1136556B1 (en) | 1991-11-25 | 2005-06-08 | Enzon, Inc. | Method of producing multivalent antigen-binding proteins |
| JPH08500962A (ja) | 1992-02-06 | 1996-02-06 | クリエイティブ バイオモレキュルズ,インコーポレイテッド | 癌マーカー用生物合成結合蛋白質 |
| EP0626012B1 (en) | 1992-02-11 | 2003-07-09 | Cell Genesys, Inc. | Homogenotization of gene-targeting events |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| WO1993021319A1 (en) | 1992-04-08 | 1993-10-28 | Cetus Oncology Corporation | HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES |
| ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
| KR100269879B1 (ko) | 1992-06-30 | 2000-10-16 | 폴 에이치. 피셔 | 항-이알비비-2모노클로날항체의 조합물 및 그 사용방법 |
| ATE149570T1 (de) | 1992-08-17 | 1997-03-15 | Genentech Inc | Bispezifische immunoadhesine |
| ZA936128B (en) | 1992-08-21 | 1995-02-20 | Genentech Inc | Method for treating a LFA-1 mediated disorder |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| EP1005870B1 (en) | 1992-11-13 | 2009-01-21 | Biogen Idec Inc. | Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| CA2103323A1 (en) | 1992-11-24 | 1994-05-25 | Gregory D. Plowman | Her4 human receptor tyrosine kinase |
| AU6527894A (en) | 1993-03-30 | 1994-10-24 | Trustees Of The University Of Pennsylvania, The | Prevention of tumors with monoclonal antibodies against (neu) |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| AU697142B2 (en) | 1993-11-23 | 1998-10-01 | Genentech Inc. | Protein tyrosine kinases named Rse |
| US5714338A (en) | 1993-12-10 | 1998-02-03 | Genentech, Inc. | Methods for diagnosis of allergy |
| ATE207366T1 (de) | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
| DE4344824C1 (de) | 1993-12-28 | 1995-08-31 | Immuno Ag | Hochkonzentriertes Immunglobulin-Präparat und Verfahren zu seiner Herstellung |
| DK0739214T3 (da) | 1994-01-18 | 1998-10-07 | Genentech Inc | Fremgangsmåde til behandling af parasitinfektionerunder anvendelse af IgE antagonister |
| ATE285475T1 (de) | 1994-02-04 | 2005-01-15 | Bio Merieux | Msrv1 virus der mit multipler sklerose verbunden ist, seine nukleären bestandteile und verwendungen |
| EP0749488A1 (en) | 1994-03-03 | 1996-12-27 | Genentech, Inc. | Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders |
| US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
| CA2195537C (en) | 1994-07-21 | 2006-09-12 | Reinder Torenbeek | Cyclic ketone peroxide formulations |
| US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| CA2207869A1 (en) | 1994-12-02 | 1996-06-06 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| EP1110953B1 (en) | 1995-03-30 | 2009-10-28 | Pfizer Products Inc. | Quinazoline derivatives |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
| GB9508537D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| WO1996040210A1 (en) | 1995-06-07 | 1996-12-19 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth of tumors |
| EP0873363B1 (en) | 1995-06-14 | 2010-10-06 | The Regents of The University of California | High affinity human antibodies to tumor antigens |
| US6284236B1 (en) * | 1995-06-29 | 2001-09-04 | Immunex Corporation | Cytokine that induces apoptosis |
| EP1666591B1 (en) * | 1995-06-29 | 2011-03-23 | Immunex Corporation | Cytokine that induces apoptosis |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| ZA966075B (en) | 1995-07-27 | 1998-01-19 | Genentech Inc | Protein formulation. |
| MX9800684A (es) * | 1995-07-27 | 1998-04-30 | Genentech Inc | Formulacion de proteinas liofilizadas isotonicas estables. |
| US6685940B2 (en) * | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US20040197326A1 (en) | 1995-07-27 | 2004-10-07 | Genentech, Inc. | Method for treatment of allergic asthma |
| US5783186A (en) | 1995-12-05 | 1998-07-21 | Amgen Inc. | Antibody-induced apoptosis |
| US6998116B1 (en) * | 1996-01-09 | 2006-02-14 | Genentech, Inc. | Apo-2 ligand |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| IL125255A (en) | 1996-01-23 | 2002-02-10 | Genentech Inc | Anti-cd18 antibodies for treating stroke |
| GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
| RO121900B1 (ro) | 1996-04-12 | 2008-07-30 | Warner-Lambert Company | Compuşi inhibitori, ireversibili, ai tirozin kinazelor, compoziţie farmaceutică care îi conţine şi utilizarea acestora |
| GB9610992D0 (en) | 1996-05-24 | 1996-07-31 | Glaxo Group Ltd | Concentrated antibody preparation |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
| US7371376B1 (en) * | 1996-10-18 | 2008-05-13 | Genentech, Inc. | Anti-ErbB2 antibodies |
| CN100415772C (zh) | 1996-10-18 | 2008-09-03 | 基因技术股份有限公司 | 抗ErbB2抗体 |
| CA2266439C (en) | 1996-10-25 | 2009-06-16 | Human Genome Sciences, Inc. | Neutrokine .alpha. |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| DK0950067T3 (da) | 1996-11-27 | 2007-12-27 | Genentech Inc | Affinitetsoprensning af polypeptid på protein A-matrix |
| EP1516629B1 (en) | 1996-11-27 | 2013-04-03 | Genentech, Inc. | Humanized anti CD-11a antibodies |
| CA2274987C (en) | 1996-12-23 | 2012-01-24 | Immunex Corporation | Ligand for receptor activator of nf-kappa b, ligand is member of tnf superfamily |
| EP1012274B2 (en) * | 1997-01-28 | 2011-06-15 | Human Genome Sciences, Inc. | Death domain containing receptor 4 (dr4: death receptor 4), member of the tnf-receptor superfamily and binding to trail (ap0-2l) |
| US6433147B1 (en) * | 1997-01-28 | 2002-08-13 | Human Genome Sciences, Inc. | Death domain containing receptor-4 |
| US6072047A (en) * | 1997-02-13 | 2000-06-06 | Immunex Corporation | Receptor that binds trail |
| US20020160446A1 (en) | 2000-11-14 | 2002-10-31 | Holtzman Douglas A. | Novel genes encoding proteins having prognostic diagnostic preventive therapeutic and other uses |
| US20010010924A1 (en) | 1997-03-14 | 2001-08-02 | Keith Charles Deen | Tumor necrosis factor related receptor, tr6 polynecleotides |
| US6313269B1 (en) | 1997-03-14 | 2001-11-06 | Smithkline Beecham Corporation | Tumor necrosis factor related receptor, TR6 |
| US6872568B1 (en) | 1997-03-17 | 2005-03-29 | Human Genome Sciences, Inc. | Death domain containing receptor 5 antibodies |
| ATE352618T1 (de) | 1997-03-17 | 2007-02-15 | Human Genome Sciences Inc | Rezeptor 5, der eine für den zelltod verantwortliche domäne enthält |
| UA73073C2 (uk) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
| US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
| ES2284203T5 (es) | 1997-04-16 | 2016-03-11 | Amgen Inc. | Proteínas de unión a osteoprotegerina y sus receptores |
| AU7126498A (en) | 1997-04-16 | 1998-11-11 | Millennium Pharmaceuticals, Inc. | Tumor necrosis factor receptor related proteins tango-63d and tango-63e |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| US6342369B1 (en) | 1997-05-15 | 2002-01-29 | Genentech, Inc. | Apo-2-receptor |
| ES2293682T5 (es) | 1997-05-15 | 2011-11-17 | Genentech, Inc. | Anticuerpo anti-apo2. |
| CA2295991A1 (en) | 1997-06-11 | 1998-12-17 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor tr9 |
| ES2190087T3 (es) | 1997-06-13 | 2003-07-16 | Genentech Inc | Formulacion estabilizada de un anticuerpo. |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| ES2244066T3 (es) | 1997-06-24 | 2005-12-01 | Genentech, Inc. | Procedimiento y composiciones de glicoproteinas galactosiladas. |
| US5994511A (en) | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| WO1999002653A1 (en) | 1997-07-11 | 1999-01-21 | Trustees Of The University Of Pennsylvania | Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use |
| ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
| TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
| JP2001514888A (ja) | 1997-08-15 | 2001-09-18 | アイドゥン ファーマシューティカルズ, インコーポレイテッド | Trailレセプター、これをコードする核酸、およびその使用方法 |
| WO1999011791A2 (en) | 1997-09-05 | 1999-03-11 | University Of Washington | Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents |
| WO1999019488A1 (en) | 1997-10-15 | 1999-04-22 | Children's Medical Center Corporation | Novel human egf receptors and use thereof |
| ATE419009T1 (de) | 1997-10-31 | 2009-01-15 | Genentech Inc | Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen |
| ZA9811162B (en) | 1997-12-12 | 2000-06-07 | Genentech Inc | Treatment with anti-ERBB2 antibodies. |
| US6740739B1 (en) | 1998-01-15 | 2004-05-25 | Genentech, Inc. | Substitutional variants of APO-2 ligand |
| JP2002500877A (ja) | 1998-01-26 | 2002-01-15 | ジェネンテク・インコーポレイテッド | 細胞死レセプター4(dr4)に対する抗体及びその使用 |
| ATE398464T1 (de) | 1998-03-27 | 2008-07-15 | Genentech Inc | Synergie zwischen apo-2 ligand und antikörper gegen her-2 |
| US6242195B1 (en) | 1998-04-02 | 2001-06-05 | Genentech, Inc. | Methods for determining binding of an analyte to a receptor |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| DE69937291T2 (de) | 1998-04-02 | 2008-07-10 | Genentech, Inc., South San Francisco | Antikörpervarianten und fragmente davon |
| US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
| PT2180007E (pt) | 1998-04-20 | 2013-11-25 | Roche Glycart Ag | Engenharia de glicosilação de anticorpos para melhorar a citotoxicidade celular dependente de anticorpos |
| US6489447B1 (en) | 1998-05-06 | 2002-12-03 | Genentech, Inc. | Protein purification |
| US6252050B1 (en) | 1998-06-12 | 2001-06-26 | Genentech, Inc. | Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method |
| US6448631B2 (en) * | 1998-09-23 | 2002-09-10 | Artisan Components, Inc. | Cell architecture with local interconnect and method for making same |
| US6573043B1 (en) | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
| KR101155191B1 (ko) | 1999-01-15 | 2012-06-13 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| AU4314900A (en) | 1999-04-28 | 2000-11-17 | Yamanouchi Pharmaceutical Co., Ltd. | Parenteral medicinal composition containing humanized monoclonal antibody fragment and method for stabilizing the same |
| ES2320311T3 (es) * | 1999-05-14 | 2009-05-21 | Genentech, Inc. | Tratamiento con anticuerpos anti-erbb2. |
| PT1181319E (pt) | 1999-05-28 | 2009-07-14 | Genentech Inc | Anticorpos quiméricos contra dr4 e suas utilizações |
| US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
| IL146491A0 (en) | 1999-06-09 | 2002-07-25 | Genentech Inc | APo-2L RECEPTOR AGONIST AND CPT-11 SYNERGISM |
| US7041292B1 (en) * | 1999-06-25 | 2006-05-09 | Genentech, Inc. | Treating prostate cancer with anti-ErbB2 antibodies |
| US20030086924A1 (en) * | 1999-06-25 | 2003-05-08 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| US20040013667A1 (en) | 1999-06-25 | 2004-01-22 | Genentech, Inc. | Treatment with anti-ErbB2 antibodies |
| MXPA01013458A (es) | 1999-06-25 | 2002-07-30 | Genentech Inc | Anticuerpos humanizados anti-erbb2 y tratamiento con anticuerpos anti-erbb2. |
| EP1189634B1 (en) * | 1999-06-25 | 2007-02-28 | Genentech, Inc. | Treating prostate cancer with anti-erbb2 antibodies |
| US6949245B1 (en) * | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| AU6338200A (en) | 1999-06-28 | 2001-01-31 | Genentech Inc. | Methods for making apo-2 ligand using divalent metal ions |
| KR20020027490A (ko) | 1999-07-12 | 2002-04-13 | 제넨테크, 인크. | Cd20에 결합하는 길항제를 사용한 외래 항원에 대한면역 반응 차단 방법 |
| HK1048260B (zh) * | 1999-08-27 | 2009-03-13 | 杰南技术公司 | 用於抗erbb2抗体治疗的制剂 |
| AU778199B2 (en) | 1999-10-29 | 2004-11-25 | Genentech Inc. | Anti-prostate stem cell antigen (PSCA) antibody compositions and methods of use |
| JP4516711B2 (ja) * | 1999-12-28 | 2010-08-04 | 中外製薬株式会社 | 安定な抗体組成物及び注射製剤 |
| US6632979B2 (en) | 2000-03-16 | 2003-10-14 | Genentech, Inc. | Rodent HER2 tumor model |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| SI2857516T1 (sl) | 2000-04-11 | 2017-09-29 | Genentech, Inc. | Multivalentna protitelesa in njihove uporabe |
| MXPA02011379A (es) * | 2000-05-19 | 2003-06-06 | Genentech Inc | Ensayo de deteccion de genes para mejorar la probabilidad de una respuesta efectiva a terapia de cancer con el antagonista erbb. |
| WO2002009755A2 (en) | 2000-07-27 | 2002-02-07 | Genentech, Inc. | Apo-2l receptor agonist and cpt-11 synergism |
| EP2311492B1 (en) * | 2000-08-11 | 2017-10-04 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing stabilized preparations |
| US6984494B2 (en) | 2000-08-15 | 2006-01-10 | Genentech, Inc. | Analytical method |
| JP4340062B2 (ja) * | 2000-10-12 | 2009-10-07 | ジェネンテック・インコーポレーテッド | 粘度の減少した濃縮タンパク質製剤 |
| CA2446723C (en) | 2001-05-25 | 2014-01-21 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| GB0113179D0 (en) * | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| US7321026B2 (en) | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| WO2003066661A2 (en) | 2001-07-03 | 2003-08-14 | Genentech, Inc. | Human dr4 antibodies and uses thereof |
| US20030113316A1 (en) | 2001-07-25 | 2003-06-19 | Kaisheva Elizabet A. | Stable lyophilized pharmaceutical formulation of IgG antibodies |
| PL377119A1 (pl) | 2001-08-03 | 2006-01-23 | Genentech, Inc. | Peptydy TACIs i BR3 i ich zastosowanie |
| NZ603111A (en) | 2001-08-03 | 2014-05-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| EP1421985B1 (en) | 2001-08-09 | 2012-05-23 | DIC Corporation | Heat resistant filter |
| ES2326964T3 (es) | 2001-10-25 | 2009-10-22 | Genentech, Inc. | Composiciones de glicoproteina. |
| ES2357225T3 (es) | 2001-11-01 | 2011-04-20 | Uab Research Foundation | Combinaciones de anticuerpos anti-dr5 y anticuerpos anti-dr4 y otros agentes terapéuticos. |
| RU2313368C2 (ru) | 2001-11-01 | 2007-12-27 | Ю Эй Би Рисерч Фаундейшн | Комбинации антител, обладающих селективностью по отношению к рецептору лиганда, индуцирующему апоптоз, ассоциированный с фактором некроза опухоли, и других терапевтических средств |
| EP1441589B1 (en) * | 2001-11-08 | 2012-05-09 | Abbott Biotherapeutics Corp. | Stable liquid pharmaceutical formulation of igg antibodies |
| WO2003042367A2 (en) | 2001-11-14 | 2003-05-22 | Human Genome Sciences, Inc. | Antibodies that immunospecifically bind to trail receptors |
| EP1451780B1 (en) * | 2001-12-05 | 2013-11-20 | Outerwall Inc. | Method and system for detecting coin fraud in coin-counting machines and other devices |
| US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| CN100522999C (zh) | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
| MXPA04007924A (es) * | 2002-02-14 | 2005-05-17 | Chugai Pharmaceutical Co Ltd | Formulaciones en solucion que contienen anticuerpo. |
| JP2005522514A (ja) | 2002-04-10 | 2005-07-28 | ジェネンテック・インコーポレーテッド | 抗her2抗体改変体 |
| US20050276812A1 (en) | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| AU2003250831A1 (en) | 2002-06-12 | 2003-12-31 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Use of hec1 antagonists in the treatment of proliferative disorders and cancer |
| US7425618B2 (en) * | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| WO2004001007A2 (en) * | 2002-06-21 | 2003-12-31 | Idec Pharmaceuticals Corporation | Buffered formulations for concentrating antibodies and methods of use thereof |
| EP1539239A4 (en) | 2002-07-02 | 2005-09-14 | Smithkline Beecham Corp | NEW STABLE FORMULATION |
| EP2263691B1 (en) * | 2002-07-15 | 2012-08-29 | F.Hoffmann-La Roche Ag | Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4) |
| US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
| US20040091490A1 (en) | 2002-08-28 | 2004-05-13 | Robert Johnson | Stable pH optimized formulation of a modified antibody |
| HUE033623T2 (en) | 2002-09-11 | 2017-12-28 | Genentech Inc | protein purification |
| ES2744275T3 (es) | 2002-10-17 | 2020-02-24 | Genmab As | Anticuerpos monoclonales humanos contra CD20 para su uso en el tratamiento de esclerosis múltiple |
| US20040258685A1 (en) | 2002-11-21 | 2004-12-23 | Genentech, Inc. | Therapy of non-malignant diseases or disorders with anti-ErbB2 antibodies |
| WO2004055164A2 (en) | 2002-12-13 | 2004-07-01 | Abgenix, Inc. | System and method for stabilizing antibodies with histidine |
| DE60332957D1 (de) | 2002-12-16 | 2010-07-22 | Genentech Inc | Immunoglobulinvarianten und deren verwendungen |
| AU2004207003A1 (en) | 2003-01-30 | 2004-08-12 | Medimmune, Llc | Anti-integrin alphanubeta3 antibody formulations and uses thereof |
| WO2004070010A2 (en) | 2003-02-01 | 2004-08-19 | Tanox, Inc. | A method for generating high affinity antibodies |
| WO2004071439A2 (en) | 2003-02-10 | 2004-08-26 | Elan Pharmaceuticals, Inc. | Immunoglobulin formulation and method of preparation thereof |
| US20040185269A1 (en) | 2003-03-18 | 2004-09-23 | Loper Scott W. | Scratch and mar resistant low VOC coating composition |
| EP2335725B1 (en) | 2003-04-04 | 2016-10-12 | Genentech, Inc. | High concentration antibody and protein formulations |
| DK3095793T3 (da) | 2003-07-28 | 2020-05-25 | Genentech Inc | Reducering af udvaskning af protein A under en protein A-affinitetskromatografi |
| WO2005099756A2 (en) * | 2004-04-08 | 2005-10-27 | Agus David B | ErbB ANTAGONISTS FOR PAIN THERAPY |
| GT200500155A (es) | 2004-06-16 | 2006-05-15 | Terapia del càncer resistente al platino | |
| KR20190126461A (ko) * | 2004-07-22 | 2019-11-11 | 제넨테크, 인크. | Her2 항체 조성물 |
| US20060029551A1 (en) | 2004-08-05 | 2006-02-09 | Kui Liu | Stable particle formulations of erythropoietin receptor agonists |
| TW200621282A (en) | 2004-08-13 | 2006-07-01 | Wyeth Corp | Stabilizing formulations |
| ZA200701715B (en) | 2004-08-19 | 2008-07-30 | Genentech Inc | Polypeptide variants with altered effector function |
| JO3000B1 (ar) | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| CN101115849A (zh) * | 2004-12-07 | 2008-01-30 | 健泰科生物技术公司 | 选择her抑制剂疗法的患者 |
| KR20200058588A (ko) * | 2005-01-21 | 2020-05-27 | 제넨테크, 인크. | Her 항체의 고정 용량 투여법 |
| MY152164A (en) * | 2005-02-23 | 2014-08-15 | Genentech Inc | Extending time to disease progression or survival in cancer patients |
| WO2006096861A2 (en) * | 2005-03-08 | 2006-09-14 | Genentech, Inc. | METHODS FOR IDENTIFYING TUMORS RESPONSIVE TO TREATMENT WITH HER DIMERIZATION INHIBITORS (HDIs) |
| US20060212956A1 (en) | 2005-03-14 | 2006-09-21 | Genentech, Inc. | Animal model of ligand activated HER2 expressing tumors |
| JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
| US20070009976A1 (en) * | 2005-07-06 | 2007-01-11 | Helmut Lenz | Detection of a target antigen irrespective of the presence or absence of a corresponding therapeutic antibody |
| PE20070207A1 (es) | 2005-07-22 | 2007-03-09 | Genentech Inc | Tratamiento combinado de los tumores que expresan el her |
| US7700299B2 (en) * | 2005-08-12 | 2010-04-20 | Hoffmann-La Roche Inc. | Method for predicting the response to a treatment |
| WO2007074880A1 (ja) | 2005-12-28 | 2007-07-05 | Chugai Seiyaku Kabushiki Kaisha | 抗体含有安定化製剤 |
| TW200812615A (en) | 2006-03-22 | 2008-03-16 | Hoffmann La Roche | Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2 |
| KR20090019890A (ko) * | 2006-06-05 | 2009-02-25 | 제넨테크, 인크. | Egf 또는 tgf-알파 수준이 상승된 암 환자의 생존 연장 |
| DK2056874T3 (da) | 2006-08-21 | 2012-10-15 | Hoffmann La Roche | Tumorterapi med et anti-vegf-antistof |
| WO2008031531A1 (en) * | 2006-09-15 | 2008-03-20 | F. Hoffmann-La Roche Ag | Tumor therapy with a combination of anti-her2 antibodies |
| KR20150039212A (ko) | 2007-03-02 | 2015-04-09 | 제넨테크, 인크. | 낮은 her3 발현을 기초로 한 her 이량체화 억제제에 대한 반응 예측 |
| EP1997534A1 (en) | 2007-05-31 | 2008-12-03 | Pierre Fabre Medicament | Cancer treatment combination therapy comprising vinflunine and trastuzumab |
| BRPI0812777A2 (pt) | 2007-06-06 | 2014-12-02 | Hoffmann La Roche | Composição de um primeiro anticorpo monoclonal não-marcado que se liga a um antígeno de tumor e de um segundo anticorpo monoclonal que não sofre reação cruzada marcado com um marcador fluorescente nir |
| SI2171090T1 (sl) | 2007-06-08 | 2013-07-31 | Genentech, Inc. | Markerji genskega izraĹľanja tumorske odpornosti na HER2 inhibitorsko zdravljenje |
| US9551033B2 (en) | 2007-06-08 | 2017-01-24 | Genentech, Inc. | Gene expression markers of tumor resistance to HER2 inhibitor treatment |
| EP2205242B1 (en) | 2007-09-12 | 2015-04-15 | Genentech, Inc. | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| BRPI0817182A2 (pt) | 2007-10-30 | 2015-03-17 | Genentech Inc | Método para purificar um anticorpo e composições |
| EP2070896A1 (en) * | 2007-12-12 | 2009-06-17 | BP p.l.c. | A process for the conversion of n-butanol to di-isobutene and propene |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| TWI472339B (zh) | 2008-01-30 | 2015-02-11 | Genentech Inc | 包含結合至her2結構域ii之抗體及其酸性變異體的組合物 |
| EP2260056A1 (en) | 2008-03-06 | 2010-12-15 | Genentech, Inc. | Combination therapy with c-met and her antagonists |
| HUE035182T2 (hu) | 2008-03-18 | 2018-05-02 | Genentech Inc | Anti-HER2 antitest-hatóanyag-konjugátum és pertuzumab kombinációi |
| BRPI0812682A2 (pt) | 2008-06-16 | 2010-06-22 | Genentech Inc | tratamento de cáncer de mama metastático |
| WO2010136569A1 (en) | 2009-05-29 | 2010-12-02 | F. Hoffmann-La Roche Ag | Modulators for her2 signaling in her2 expressing patients with gastric cancer |
| US9345661B2 (en) | 2009-07-31 | 2016-05-24 | Genentech, Inc. | Subcutaneous anti-HER2 antibody formulations and uses thereof |
| WO2011146568A1 (en) | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| EP2648719A1 (en) | 2010-12-09 | 2013-10-16 | F.Hoffmann-La Roche Ag | Treatment of her2-positive cancer with paclitaxel and trastuzumab-mcc-dm1 |
| EP2683413A1 (en) | 2011-03-07 | 2014-01-15 | F.Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
| BR112014007521A8 (pt) | 2011-10-14 | 2018-04-10 | Genentech Inc | método para estender a sobrevida livre de progressão em uma população com câncer de mama, artigo de fabricação, método para produção de um artigo de fabricação, para garantir o uso seguro e efetivo de pertuzumabe, de tratar câncer de mama, bolsa intravenosa, método de tratar câncer gástrico, de tratar adenocarcinoma do estômago e de melhora de sobrevida |
| EP2788500A1 (en) | 2011-12-09 | 2014-10-15 | F.Hoffmann-La Roche Ag | Identification of non-responders to her2 inhibitors |
| EP2793941A1 (en) | 2011-12-23 | 2014-10-29 | F.Hoffmann-La Roche Ag | Articles of manufacture and methods for co-administration of antibodies |
| EP2858666B1 (en) | 2012-06-08 | 2019-09-04 | F.Hoffmann-La Roche Ag | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| AR094403A1 (es) | 2013-01-11 | 2015-07-29 | Hoffmann La Roche | Terapia de combinación de anticuerpos anti-her3 |
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- 2005-10-18 JO JOP/2005/0155A patent/JO3000B1/ar active
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003105894A1 (en) * | 2002-06-14 | 2003-12-24 | Medimmune, Inc. | Stabilized liquid anti-rsv antibody formulations |
Non-Patent Citations (1)
| Title |
|---|
| Pharmaceutical Research, Vol. 20, No. 12,pp.1952-1960 ,December 2003. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI835773B (zh) * | 2018-01-26 | 2024-03-21 | 美商建南德克公司 | 組合物及使用方法 |
| US12171805B2 (en) | 2018-01-26 | 2024-12-24 | Genentech, Inc. | IL-22 FC compositions |
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