PE20071063A1 - Formulaciones de proteinas estables - Google Patents

Formulaciones de proteinas estables

Info

Publication number
PE20071063A1
PE20071063A1 PE2006001649A PE2006001649A PE20071063A1 PE 20071063 A1 PE20071063 A1 PE 20071063A1 PE 2006001649 A PE2006001649 A PE 2006001649A PE 2006001649 A PE2006001649 A PE 2006001649A PE 20071063 A1 PE20071063 A1 PE 20071063A1
Authority
PE
Peru
Prior art keywords
sugar
protein formulations
stable protein
formulation
ctla4ig
Prior art date
Application number
PE2006001649A
Other languages
English (en)
Inventor
Manisha M Dali
Charles E Dahlheim
Sunita Borsadia
Vijay H Naringrekar
Rajesh B Gandhi
Manoj Nerurkar
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38057529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20071063(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20071063A1 publication Critical patent/PE20071063A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

REFERIDA A UNA FORMULACION ESTABLE QUE COMPRENDE AL MENOS 100 MG/ML DE MOLECULAS DE CTLA4Ig, UN AZUCAR TAL COMO SUCROSA, MALTOSA, LACTOSA, MANITOL, ENTRE OTRAS, Y UN PORTADOR ACUOSO FARMACEUTICAMENTE ACEPTABLE. LA MOLECULA CTLA4Ig TIENE LA SECUENCIA DE AMINOACIDOS MOSTRADA EN LA SEQ ID NO:2 COMENZANDO CON METIONINA EN LA POSICION 27 O ALANINA EN LA POSICION 26 Y TERMINANDO EN LA LISINA EN LA POSICION 383 O GLICINA EN LA POSICION 382. DICHA FORMULACION TIENE UNA PROPORCION DE PROTEINA Y AZUCAR DE 1:1.3 Y TIENE UN pH ENTRE 6 Y 8. LA FORMULACION PUEDE SER LIOFILIZADA O LIQUIDA Y SE PUEDE ADMINISTRAR VIA INTRAVENOSA O SUBCUTANEA
PE2006001649A 2005-12-20 2006-12-19 Formulaciones de proteinas estables PE20071063A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75215005P 2005-12-20 2005-12-20

Publications (1)

Publication Number Publication Date
PE20071063A1 true PE20071063A1 (es) 2007-10-24

Family

ID=38057529

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001649A PE20071063A1 (es) 2005-12-20 2006-12-19 Formulaciones de proteinas estables

Country Status (25)

Country Link
US (1) US8476239B2 (es)
EP (1) EP1962886B2 (es)
JP (2) JP5247467B2 (es)
KR (1) KR101378194B1 (es)
CN (3) CN101822820A (es)
AR (2) AR058567A1 (es)
AU (1) AU2006330593B2 (es)
BR (1) BRPI0622256A2 (es)
CA (1) CA2634547C (es)
CL (1) CL2010000816A1 (es)
DK (1) DK1962886T4 (es)
EA (1) EA014232B1 (es)
ES (1) ES2436616T5 (es)
HK (1) HK1114568A1 (es)
HR (1) HRP20131196T4 (es)
IL (1) IL192104A (es)
NO (1) NO347247B1 (es)
NZ (1) NZ569108A (es)
PE (1) PE20071063A1 (es)
PL (1) PL1962886T6 (es)
PT (1) PT1962886E (es)
RS (1) RS53127B2 (es)
SG (1) SG153832A1 (es)
TW (3) TW201008595A (es)
WO (1) WO2007076354A2 (es)

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Also Published As

Publication number Publication date
PT1962886E (pt) 2014-01-07
JP5247467B2 (ja) 2013-07-24
EP1962886B1 (en) 2013-10-16
PL1962886T3 (pl) 2014-03-31
WO2007076354A3 (en) 2007-08-16
NZ569108A (en) 2011-09-30
CN101378773B (zh) 2013-03-13
US8476239B2 (en) 2013-07-02
DK1962886T3 (da) 2014-01-13
BRPI0622256A2 (pt) 2011-08-09
EA014232B1 (ru) 2010-10-29
SG153832A1 (en) 2009-07-29
CL2010000816A1 (es) 2011-02-11
IL192104A0 (en) 2008-12-29
NO20082628L (no) 2008-07-15
CN101378773A (zh) 2009-03-04
NO347247B1 (no) 2023-07-31
AU2006330593A1 (en) 2007-07-05
IL192104A (en) 2015-01-29
KR20080078070A (ko) 2008-08-26
JP5538309B2 (ja) 2014-07-02
HRP20131196T4 (hr) 2022-06-10
DK1962886T4 (da) 2022-05-02
ES2436616T3 (es) 2014-01-03
TWI393575B (zh) 2013-04-21
RS53127B (en) 2014-06-30
EA200801570A1 (ru) 2008-12-30
CA2634547C (en) 2016-10-11
EP1962886B2 (en) 2022-02-23
PL1962886T6 (pl) 2023-03-13
HK1114568A1 (en) 2008-11-07
KR101378194B1 (ko) 2014-03-27
TW201008596A (en) 2010-03-01
CA2634547A1 (en) 2007-07-05
AR097561A2 (es) 2016-03-23
JP2011246470A (ja) 2011-12-08
AU2006330593B2 (en) 2012-07-26
JP2009524595A (ja) 2009-07-02
CN101584858A (zh) 2009-11-25
HRP20131196T1 (en) 2014-01-31
US20100166774A1 (en) 2010-07-01
ES2436616T5 (es) 2022-05-27
TW200738261A (en) 2007-10-16
AR058567A1 (es) 2008-02-13
BRPI0620186A2 (pt) 2010-07-06
WO2007076354A2 (en) 2007-07-05
TW201008595A (en) 2010-03-01
EP1962886A2 (en) 2008-09-03
RS53127B2 (sr) 2022-06-30
CN101822820A (zh) 2010-09-08

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