AU4803890A - Use of basic amino acids to solubilize immunoglobulins - Google Patents

Use of basic amino acids to solubilize immunoglobulins

Info

Publication number
AU4803890A
AU4803890A AU48038/90A AU4803890A AU4803890A AU 4803890 A AU4803890 A AU 4803890A AU 48038/90 A AU48038/90 A AU 48038/90A AU 4803890 A AU4803890 A AU 4803890A AU 4803890 A AU4803890 A AU 4803890A
Authority
AU
Australia
Prior art keywords
solubilize
immunoglobulins
amino acids
basic amino
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU48038/90A
Inventor
Bill Moellering
Christopher P. Prior
Garance Prior
Barbara Tipton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Invitron Corp
Original Assignee
Invitron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitron Corp filed Critical Invitron Corp
Publication of AU4803890A publication Critical patent/AU4803890A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70514—CD4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AU48038/90A 1988-12-15 1989-12-06 Use of basic amino acids to solubilize immunoglobulins Abandoned AU4803890A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28515488A 1988-12-15 1988-12-15
US285154 1988-12-15

Publications (1)

Publication Number Publication Date
AU4803890A true AU4803890A (en) 1990-07-10

Family

ID=23092978

Family Applications (1)

Application Number Title Priority Date Filing Date
AU48038/90A Abandoned AU4803890A (en) 1988-12-15 1989-12-06 Use of basic amino acids to solubilize immunoglobulins

Country Status (5)

Country Link
EP (1) EP0448605A4 (en)
JP (1) JPH04502914A (en)
AU (1) AU4803890A (en)
CA (1) CA2005119A1 (en)
WO (1) WO1990006764A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
PT100580A (en) * 1991-06-12 1993-09-30 Regeneron Pharma PRODUCTION AND RECOVERY OF RECOMBINANT NEUROTROPHINS
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
EP1314437B1 (en) 2000-08-11 2014-06-25 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing preparations
JP5290489B2 (en) * 2001-11-08 2013-09-18 アッヴィ・バイオセラピューティクス・インコーポレイテッド Stable liquid pharmaceutical formulation of IGG antibody
US20060182740A1 (en) * 2002-06-21 2006-08-17 Biogen Idec, Inc. Buffered formulations for concentrating antibodies and methods of use thereof
US8080642B2 (en) 2003-05-16 2011-12-20 Vical Incorporated Severe acute respiratory syndrome DNA compositions and methods of use
JO3000B1 (en) * 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
CN103282042B (en) * 2010-09-17 2014-12-10 巴克斯特国际公司 Stabilization of immunoglobulins through aqueous formulation with histidine at weak acidic to neutral pH

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362661A (en) * 1979-08-09 1982-12-07 Teijin Limited Immunoglobulin composition having a high monomer content, and process for production thereof
JPS56113713A (en) * 1980-02-14 1981-09-07 Chemo Sero Therapeut Res Inst Preparation of immunoglobulin with high content of monomer
JPH0247447B2 (en) * 1982-05-27 1990-10-19 Teijin Ltd KOHOTAIKANOHIKUIIGMSOSEIBUTSU
DE3584902D1 (en) * 1984-02-29 1992-01-30 Asahi Chemical Ind AQUEOUS SOLUTION OF AN INCREASED CONCENTRATION OF TISSUE PLASMINOGEN ACTIVATOR AND PRODUCTION METHOD.
JPS60243028A (en) * 1984-04-28 1985-12-03 Kyowa Hakko Kogyo Co Ltd Solubilization of interferon
US4597966A (en) * 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
JPH0672105B2 (en) * 1985-10-02 1994-09-14 持田製薬株式会社 Thrombolytic agent and manufacturing method thereof

Also Published As

Publication number Publication date
EP0448605A1 (en) 1991-10-02
WO1990006764A1 (en) 1990-06-28
EP0448605A4 (en) 1991-11-21
CA2005119A1 (en) 1990-06-15
JPH04502914A (en) 1992-05-28

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