EP0448605A4 - Use of basic amino acids to solubilize immunoglobulins - Google Patents
Use of basic amino acids to solubilize immunoglobulinsInfo
- Publication number
- EP0448605A4 EP0448605A4 EP19900900689 EP90900689A EP0448605A4 EP 0448605 A4 EP0448605 A4 EP 0448605A4 EP 19900900689 EP19900900689 EP 19900900689 EP 90900689 A EP90900689 A EP 90900689A EP 0448605 A4 EP0448605 A4 EP 0448605A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- solubilize
- immunoglobulins
- amino acids
- basic amino
- basic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28515488A | 1988-12-15 | 1988-12-15 | |
US285154 | 1988-12-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0448605A1 EP0448605A1 (en) | 1991-10-02 |
EP0448605A4 true EP0448605A4 (en) | 1991-11-21 |
Family
ID=23092978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19900900689 Withdrawn EP0448605A4 (en) | 1988-12-15 | 1989-12-06 | Use of basic amino acids to solubilize immunoglobulins |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0448605A4 (en) |
JP (1) | JPH04502914A (en) |
AU (1) | AU4803890A (en) |
CA (1) | CA2005119A1 (en) |
WO (1) | WO1990006764A1 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5180820A (en) * | 1989-08-30 | 1993-01-19 | Barde Yves Alain | Brain-derived neurotrophic factor |
US5389529A (en) * | 1991-06-12 | 1995-02-14 | Regeneron Pharmaceuticals, Inc. | Modified lamβ signal sequence and processes for producing recombinant neurotrophins |
NZ243084A (en) * | 1991-06-12 | 1995-08-28 | Regeneron Pharma | Production and recovery of recombinant neurotrophins, genes for a modified lamb signal sequence, fusion genes and plasmids |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
ES2644275T3 (en) | 2000-08-11 | 2017-11-28 | Chugai Seiyaku Kabushiki Kaisha | Stabilized preparations containing antibodies |
CA2466034C (en) * | 2001-11-08 | 2012-12-18 | Protein Design Labs, Inc. | Stable aqueous pharmaceutical formulations of daclizumab antibodies |
WO2004001007A2 (en) * | 2002-06-21 | 2003-12-31 | Idec Pharmaceuticals Corporation | Buffered formulations for concentrating antibodies and methods of use thereof |
US8080642B2 (en) | 2003-05-16 | 2011-12-20 | Vical Incorporated | Severe acute respiratory syndrome DNA compositions and methods of use |
JO3000B1 (en) * | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
JP6055412B2 (en) | 2010-09-17 | 2016-12-27 | バクスアルタ ゲーエムベーハー | Immunoglobulin stabilization via aqueous formulations with histidine at mildly acidic to neutral pH |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0035616A1 (en) * | 1980-02-14 | 1981-09-16 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Production of immunoglobulin having a high monomer content |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4362661A (en) * | 1979-08-09 | 1982-12-07 | Teijin Limited | Immunoglobulin composition having a high monomer content, and process for production thereof |
JPH0247447B2 (en) * | 1982-05-27 | 1990-10-19 | Teijin Ltd | KOHOTAIKANOHIKUIIGMSOSEIBUTSU |
DE3584902D1 (en) * | 1984-02-29 | 1992-01-30 | Asahi Chemical Ind | AQUEOUS SOLUTION OF AN INCREASED CONCENTRATION OF TISSUE PLASMINOGEN ACTIVATOR AND PRODUCTION METHOD. |
JPS60243028A (en) * | 1984-04-28 | 1985-12-03 | Kyowa Hakko Kogyo Co Ltd | Solubilization of interferon |
US4597966A (en) * | 1985-01-09 | 1986-07-01 | Ortho Diagnostic Systems, Inc. | Histidine stabilized immunoglobulin and method of preparation |
JPH0672105B2 (en) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | Thrombolytic agent and manufacturing method thereof |
-
1989
- 1989-12-06 EP EP19900900689 patent/EP0448605A4/en not_active Withdrawn
- 1989-12-06 JP JP2501391A patent/JPH04502914A/en active Pending
- 1989-12-06 WO PCT/US1989/005516 patent/WO1990006764A1/en not_active Application Discontinuation
- 1989-12-06 AU AU48038/90A patent/AU4803890A/en not_active Abandoned
- 1989-12-11 CA CA002005119A patent/CA2005119A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0035616A1 (en) * | 1980-02-14 | 1981-09-16 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Production of immunoglobulin having a high monomer content |
Non-Patent Citations (2)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 8, no. 46 (C-212)(1483) February 29, 1984 & JP-A-58 206 531 (TEIJIN K.K.) December 1, 1983 * |
See also references of WO9006764A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0448605A1 (en) | 1991-10-02 |
JPH04502914A (en) | 1992-05-28 |
WO1990006764A1 (en) | 1990-06-28 |
AU4803890A (en) | 1990-07-10 |
CA2005119A1 (en) | 1990-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19910617 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE ES FR GB IT LI LU NL SE |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19910930 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE ES FR GB IT LI LU NL SE |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: PRIOR, GARANCE Inventor name: TIPTON, BARBARA Inventor name: MOELLERING, BILL Inventor name: PRIOR, CHRISTOPHER, P. |
|
RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: CENTOCOR INC. |
|
17Q | First examination report despatched |
Effective date: 19920915 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19930326 |