EP0448605A4 - Use of basic amino acids to solubilize immunoglobulins - Google Patents

Use of basic amino acids to solubilize immunoglobulins

Info

Publication number
EP0448605A4
EP0448605A4 EP19900900689 EP90900689A EP0448605A4 EP 0448605 A4 EP0448605 A4 EP 0448605A4 EP 19900900689 EP19900900689 EP 19900900689 EP 90900689 A EP90900689 A EP 90900689A EP 0448605 A4 EP0448605 A4 EP 0448605A4
Authority
EP
European Patent Office
Prior art keywords
solubilize
immunoglobulins
amino acids
basic amino
basic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900900689
Other versions
EP0448605A1 (en
Inventor
Christopher P. Prior
Bill Moellering
Barbara Tipton
Garance Prior
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Invitron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invitron Corp filed Critical Invitron Corp
Publication of EP0448605A1 publication Critical patent/EP0448605A1/en
Publication of EP0448605A4 publication Critical patent/EP0448605A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065Purification, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591Stabilisation, fragmentation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183Amino acids, e.g. glycine, EDTA or aspartame
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70514CD4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
EP19900900689 1988-12-15 1989-12-06 Use of basic amino acids to solubilize immunoglobulins Withdrawn EP0448605A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28515488A 1988-12-15 1988-12-15
US285154 1988-12-15

Publications (2)

Publication Number Publication Date
EP0448605A1 EP0448605A1 (en) 1991-10-02
EP0448605A4 true EP0448605A4 (en) 1991-11-21

Family

ID=23092978

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900900689 Withdrawn EP0448605A4 (en) 1988-12-15 1989-12-06 Use of basic amino acids to solubilize immunoglobulins

Country Status (5)

Country Link
EP (1) EP0448605A4 (en)
JP (1) JPH04502914A (en)
AU (1) AU4803890A (en)
CA (1) CA2005119A1 (en)
WO (1) WO1990006764A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180820A (en) * 1989-08-30 1993-01-19 Barde Yves Alain Brain-derived neurotrophic factor
US5389529A (en) * 1991-06-12 1995-02-14 Regeneron Pharmaceuticals, Inc. Modified lamβ signal sequence and processes for producing recombinant neurotrophins
NZ243084A (en) * 1991-06-12 1995-08-28 Regeneron Pharma Production and recovery of recombinant neurotrophins, genes for a modified lamb signal sequence, fusion genes and plasmids
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
ES2644275T3 (en) 2000-08-11 2017-11-28 Chugai Seiyaku Kabushiki Kaisha Stabilized preparations containing antibodies
CA2466034C (en) * 2001-11-08 2012-12-18 Protein Design Labs, Inc. Stable aqueous pharmaceutical formulations of daclizumab antibodies
WO2004001007A2 (en) * 2002-06-21 2003-12-31 Idec Pharmaceuticals Corporation Buffered formulations for concentrating antibodies and methods of use thereof
US8080642B2 (en) 2003-05-16 2011-12-20 Vical Incorporated Severe acute respiratory syndrome DNA compositions and methods of use
JO3000B1 (en) * 2004-10-20 2016-09-05 Genentech Inc Antibody Formulations.
JP6055412B2 (en) 2010-09-17 2016-12-27 バクスアルタ ゲーエムベーハー Immunoglobulin stabilization via aqueous formulations with histidine at mildly acidic to neutral pH

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035616A1 (en) * 1980-02-14 1981-09-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Production of immunoglobulin having a high monomer content

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362661A (en) * 1979-08-09 1982-12-07 Teijin Limited Immunoglobulin composition having a high monomer content, and process for production thereof
JPH0247447B2 (en) * 1982-05-27 1990-10-19 Teijin Ltd KOHOTAIKANOHIKUIIGMSOSEIBUTSU
DE3584902D1 (en) * 1984-02-29 1992-01-30 Asahi Chemical Ind AQUEOUS SOLUTION OF AN INCREASED CONCENTRATION OF TISSUE PLASMINOGEN ACTIVATOR AND PRODUCTION METHOD.
JPS60243028A (en) * 1984-04-28 1985-12-03 Kyowa Hakko Kogyo Co Ltd Solubilization of interferon
US4597966A (en) * 1985-01-09 1986-07-01 Ortho Diagnostic Systems, Inc. Histidine stabilized immunoglobulin and method of preparation
JPH0672105B2 (en) * 1985-10-02 1994-09-14 持田製薬株式会社 Thrombolytic agent and manufacturing method thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0035616A1 (en) * 1980-02-14 1981-09-16 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Production of immunoglobulin having a high monomer content

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 8, no. 46 (C-212)(1483) February 29, 1984 & JP-A-58 206 531 (TEIJIN K.K.) December 1, 1983 *
See also references of WO9006764A1 *

Also Published As

Publication number Publication date
EP0448605A1 (en) 1991-10-02
JPH04502914A (en) 1992-05-28
WO1990006764A1 (en) 1990-06-28
AU4803890A (en) 1990-07-10
CA2005119A1 (en) 1990-06-15

Similar Documents

Publication Publication Date Title
HU896359D0 (en) Process for the preparation of peptide derivatives
IL81049A0 (en) Preparation of(s)-alpha-methylarylacetic acids
EP0488467A3 (en) Preparation of alkoxyalkanoic acids
GB2182037B (en) Crystalline-liquid ferro-electric derivatives of branched acyclic alpha-chlorocarboxylic acids
IL89534A0 (en) Preparation of 1-cyclopropyl-quinolone-carboxylic acids and derivatives thereof and certain novel n-cyclopropyl-anilines used therein
EP0448605A4 (en) Use of basic amino acids to solubilize immunoglobulins
PL261087A1 (en) Method of obtaining novel derivatives of amino acids
IL87185A (en) Preparation of quinolone- carboxylic acids
GB2216522B (en) Amino acid salts of long chain unsaturated fatty acid
GB8529199D0 (en) Preparation of oxo-alkanedioic acids
GB8827083D0 (en) Trialkylsilyl esters of amino acids & their use in synthesis of peptides
EP0536960A3 (en) Preparation of 2-hydroxymandelic acids and 2-hydroxybenzaldehydes
PH24307A (en) New derivatives of bicyclic amino acids
AU4665289A (en) N-alkylation of n-alpha-boc-protected amino acids
NZ234102A (en) Preparation of alpha-alkoxyacetic acids and their salts
IL92279A0 (en) Preparation of 2-chloro-4-toluenesulfonic acid
IL82670A0 (en) Preparation of oxetane-3-carboxylic acids
NZ234101A (en) Preparation of alpha-aryloxyacetic acids and their salts
IL93625A0 (en) Synthesis of hydroxy-substituted-4-alkoxyphenyl-acetic acids
CS558788A1 (en) Method of 4-chloro-2-methylphenoxyalkane acids preparation
GB8808440D0 (en) Preparation of peptide derivatives
IE891275L (en) Use of 3-methyl-flavone-8-carboxylic acids
IE881525L (en) Preparation of protein
ZA86235B (en) Process for the preparation of esters of amino acids
GB8814698D0 (en) Dehydration of acids

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19910617

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE ES FR GB IT LI LU NL SE

A4 Supplementary search report drawn up and despatched

Effective date: 19910930

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE ES FR GB IT LI LU NL SE

RIN1 Information on inventor provided before grant (corrected)

Inventor name: PRIOR, GARANCE

Inventor name: TIPTON, BARBARA

Inventor name: MOELLERING, BILL

Inventor name: PRIOR, CHRISTOPHER, P.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CENTOCOR INC.

17Q First examination report despatched

Effective date: 19920915

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19930326