DOP2015000268A - Composiciones y métodos para modular la expresión de ttr y vhb - Google Patents

Composiciones y métodos para modular la expresión de ttr y vhb

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Publication number
DOP2015000268A
DOP2015000268A DO2015000268A DO2015000268A DOP2015000268A DO P2015000268 A DOP2015000268 A DO P2015000268A DO 2015000268 A DO2015000268 A DO 2015000268A DO 2015000268 A DO2015000268 A DO 2015000268A DO P2015000268 A DOP2015000268 A DO P2015000268A
Authority
DO
Dominican Republic
Prior art keywords
vhb
ttr
modulate
expression
compositions
Prior art date
Application number
DO2015000268A
Other languages
English (en)
Spanish (es)
Inventor
Eric E Swayze
Punit P Seth
Thazha P Prakash
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51843959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DOP2015000268(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of DOP2015000268A publication Critical patent/DOP2015000268A/es

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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