NL301341I2 - eplontersen, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout - Google Patents
eplontersen, desgewenst in de vorm van een farmaceutisch aanvaardbaar zoutInfo
- Publication number
- NL301341I2 NL301341I2 NL301341C NL301341C NL301341I2 NL 301341 I2 NL301341 I2 NL 301341I2 NL 301341 C NL301341 C NL 301341C NL 301341 C NL301341 C NL 301341C NL 301341 I2 NL301341 I2 NL 301341I2
- Authority
- NL
- Netherlands
- Prior art keywords
- eplontersen
- optionally
- pharmaceutically acceptable
- acceptable salt
- salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/03—Phosphoric monoester hydrolases (3.1.3)
- C12Y301/03048—Protein-tyrosine-phosphatase (3.1.3.48)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3511—Conjugate intercalating or cleaving agent
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3513—Protein; Peptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Virology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Liquid Crystal Substances (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361818442P | 2013-05-01 | 2013-05-01 | |
| US201361823826P | 2013-05-15 | 2013-05-15 | |
| US201361843887P | 2013-07-08 | 2013-07-08 | |
| US201361871673P | 2013-08-29 | 2013-08-29 | |
| US201361880790P | 2013-09-20 | 2013-09-20 | |
| US201461976991P | 2014-04-08 | 2014-04-08 | |
| US201461986867P | 2014-04-30 | 2014-04-30 | |
| EP14791344.6A EP2992098B1 (en) | 2013-05-01 | 2014-05-01 | Compositions and methods for modulating hbv and ttr expression |
| PCT/US2014/036463 WO2014179627A2 (en) | 2013-05-01 | 2014-05-01 | Compositions and methods for modulating hbv and ttr expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL301341I2 true NL301341I2 (nl) | 2025-10-02 |
Family
ID=51843959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL301341C NL301341I2 (nl) | 2013-05-01 | 2025-09-03 | eplontersen, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout |
Country Status (40)
Families Citing this family (510)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3335715A3 (en) | 2008-10-15 | 2018-08-08 | Ionis Pharmaceuticals, Inc. | Modulation of factor 11 expression |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| WO2011005761A1 (en) | 2009-07-06 | 2011-01-13 | Ontorii, Inc | Novel nucleic acid prodrugs and methods use thereof |
| WO2012039448A1 (ja) | 2010-09-24 | 2012-03-29 | 株式会社キラルジェン | 不斉補助基 |
| JP6126009B2 (ja) | 2010-11-17 | 2017-05-10 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. | α−シヌクレイン発現の調節 |
| EP2734208B1 (en) | 2011-07-19 | 2017-03-01 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| EP3453761A1 (en) | 2011-08-29 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| EP2831231A1 (en) | 2012-03-30 | 2015-02-04 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome |
| US9914922B2 (en) * | 2012-04-20 | 2018-03-13 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| US9574193B2 (en) | 2012-05-17 | 2017-02-21 | Ionis Pharmaceuticals, Inc. | Methods and compositions for modulating apolipoprotein (a) expression |
| US20160002624A1 (en) | 2012-05-17 | 2016-01-07 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions |
| SI2855500T1 (sl) * | 2012-05-24 | 2020-10-30 | Ionis Pharmaceuticals, Inc. | Postopki in sestavki za moduliranje izražanja apolipoproteina(A) |
| CN104661664B (zh) | 2012-07-13 | 2020-07-03 | 波涛生命科学有限公司 | 手性控制 |
| AU2013287630B2 (en) | 2012-07-13 | 2017-05-25 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| AU2013288048A1 (en) | 2012-07-13 | 2015-01-22 | Wave Life Sciences Ltd. | Asymmetric auxiliary group |
| BR112015010116A2 (pt) | 2012-11-15 | 2017-08-22 | Roche Innovation Ct Copenhagen As | COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB |
| HK1215718A1 (zh) * | 2013-01-30 | 2016-09-09 | F. Hoffmann-La Roche Ag | Lna寡核苷酸碳水化合物缀合物 |
| AU2014216137B2 (en) | 2013-02-14 | 2018-05-10 | Ionis Pharmaceuticals, Inc. | Modulation of Apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations |
| US9506030B2 (en) | 2013-05-01 | 2016-11-29 | Regulus Therapeutics Inc. | Compounds and methods for enhanced cellular uptake |
| IL296543B2 (en) * | 2013-05-01 | 2025-02-01 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating HBV and TTR expression |
| SG10201803157XA (en) | 2013-05-01 | 2018-05-30 | Regulus Therapeutics Inc | Microrna compounds and methods for modulating mir-122 |
| JP6255092B2 (ja) | 2013-06-27 | 2017-12-27 | ロシュ イノベーション センター コペンハーゲン エーエス | Pcsk9を標的とするアンチセンスオリゴマーおよびコンジュゲート |
| EP4039278A1 (en) * | 2013-07-11 | 2022-08-10 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| EP3022176B8 (en) | 2013-07-15 | 2019-12-25 | The Regents of the University of California | Azacyclic constrained analogs of fty720 |
| TWI772856B (zh) | 2013-07-19 | 2022-08-01 | 美商百健Ma公司 | 用於調節τ蛋白表現之組合物 |
| WO2015042447A1 (en) | 2013-09-20 | 2015-03-26 | Isis Pharmaceuticals, Inc. | Targeted therapeutic nucleosides and their use |
| CA2925107A1 (en) * | 2013-10-02 | 2015-04-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the lect2 gene |
| US11162096B2 (en) | 2013-10-14 | 2021-11-02 | Ionis Pharmaceuticals, Inc | Methods for modulating expression of C9ORF72 antisense transcript |
| US9994846B2 (en) * | 2013-10-25 | 2018-06-12 | Regulus Therapeutics Inc. | MicroRNA compounds and methods for modulating miR-21 activity |
| EP3068885A1 (en) * | 2013-11-14 | 2016-09-21 | Roche Innovation Center Copenhagen A/S | Apob antisense conjugate compounds |
| JP6482475B2 (ja) * | 2014-01-07 | 2019-03-13 | レナセラピューティクス株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| EP3095459A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having antitumor effect and antitumor agent |
| US10144933B2 (en) | 2014-01-15 | 2018-12-04 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator |
| EP3095460A4 (en) | 2014-01-15 | 2017-08-23 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent |
| CN113278617A (zh) | 2014-01-16 | 2021-08-20 | 波涛生命科学有限公司 | 手性设计 |
| JP6594902B2 (ja) | 2014-02-11 | 2019-10-23 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | ケトヘキソキナーゼ(KHK)iRNA組成物及びその使用方法 |
| CA2942340A1 (en) | 2014-03-19 | 2015-09-24 | Ionis Pharmaceuticals, Inc. | Compositions for modulating ataxin 2 expression |
| US10006027B2 (en) | 2014-03-19 | 2018-06-26 | Ionis Pharmaceuticals, Inc. | Methods for modulating Ataxin 2 expression |
| EP4137573A3 (en) | 2014-04-01 | 2023-05-03 | Biogen MA Inc. | Compositions for modulating sod-1 expression |
| KR20200102553A (ko) | 2014-05-01 | 2020-08-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | 성장 호르몬 수용체 발현을 조절하기 위한 조성물 및 방법 |
| BR122020024443B1 (pt) | 2014-05-01 | 2022-02-22 | Ionis Pharmaceuticals, Inc | Composto e composição farmacêutica para modulação da expressão de angptl3 |
| EP4534092A3 (en) | 2014-05-01 | 2025-07-02 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating pkk expression |
| EP3811977B1 (en) * | 2014-05-01 | 2025-12-03 | Ionis Pharmaceuticals, Inc. | Method for synthesis of reactive conjugate clusters |
| UA121656C2 (uk) | 2014-05-01 | 2020-07-10 | Айоніс Фармасьютикалз, Інк. | Олігомерна сполука та спосіб лікування захворювання, пов'язаного з порушенням регуляції альтернативного шляху комплементу |
| GB201408623D0 (en) * | 2014-05-15 | 2014-07-02 | Santaris Pharma As | Oligomers and oligomer conjugates |
| SG10202104570TA (en) | 2014-05-22 | 2021-06-29 | Alnylam Pharmaceuticals Inc | Angiotensinogen (agt) irna compositions and methods of use thereof |
| GB201410693D0 (en) | 2014-06-16 | 2014-07-30 | Univ Southampton | Splicing modulation |
| EP3177721A1 (en) | 2014-08-07 | 2017-06-14 | Regulus Therapeutics Inc. | Targeting micrornas for metabolic disorders |
| BR112017004056A2 (pt) | 2014-09-12 | 2017-12-05 | Biogen Ma Inc | composições e métodos para detecção da proteína smn em um indivíduo e tratamento de um indivíduo |
| EP3201339A4 (en) | 2014-10-03 | 2018-09-19 | Cold Spring Harbor Laboratory | Targeted augmentation of nuclear gene output |
| RU2017114156A (ru) * | 2014-10-10 | 2018-11-15 | Ф. Хоффманн-Ля Рош Аг | N-ацетилгалактозаминовые (galnac) фосфорамитиды, их конъюгаты с нуклеиновыми кислотами и их применение |
| EP3207138B1 (en) * | 2014-10-17 | 2020-07-15 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof |
| JOP20200092A1 (ar) | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
| HK1244843A1 (zh) | 2014-11-17 | 2018-08-17 | Alnylam Pharmaceuticals, Inc. | 载脂蛋白c3(apoc3)irna组合物及其使用方法 |
| EP3234141A4 (en) | 2014-12-18 | 2018-06-20 | Alnylam Pharmaceuticals, Inc. | Reversir tm compounds |
| US10793855B2 (en) | 2015-01-06 | 2020-10-06 | Ionis Pharmaceuticals, Inc. | Compositions for modulating expression of C9ORF72 antisense transcript |
| WO2016115490A1 (en) | 2015-01-16 | 2016-07-21 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulation of dux4 |
| EP3256587A2 (en) | 2015-02-13 | 2017-12-20 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| CN107466323A (zh) * | 2015-02-15 | 2017-12-12 | 阿克丘勒斯治疗公司 | 酰基‑氨基‑lna和/或烃基‑氨基‑lna寡核苷酸 |
| US11129844B2 (en) | 2015-03-03 | 2021-09-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating MECP2 expression |
| EP3929293A3 (en) | 2015-04-03 | 2022-03-16 | University Of Massachusetts | Fully stabilized asymmetric sirna |
| MX2017012426A (es) | 2015-04-03 | 2018-01-26 | Ionis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de tmprss6. |
| US10745702B2 (en) | 2015-04-08 | 2020-08-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the LECT2 gene |
| WO2016167780A1 (en) | 2015-04-16 | 2016-10-20 | Ionis Pharmaceuticals, Inc. | Compositions for modulating expression of c9orf72 antisense transcript |
| EP3286310A4 (en) | 2015-04-24 | 2019-01-09 | California Institute of Technology | REACTIVATION OF X-CHROMOSOME GENES |
| EP3310918B1 (en) | 2015-06-18 | 2020-08-05 | Alnylam Pharmaceuticals, Inc. | Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof |
| WO2016209862A1 (en) | 2015-06-23 | 2016-12-29 | Alnylam Pharmaceuticals, Inc. | Glucokinase (gck) irna compositions and methods of use thereof |
| EP4545544A3 (en) | 2015-06-29 | 2025-10-08 | Ionis Pharmaceuticals, Inc. | Modified crispr rna and modified single crispr rna and uses thereof |
| BR112017028194B1 (pt) | 2015-07-10 | 2023-03-14 | Ionis Pharmaceuticals, Inc | Composto oligomérico modulador de diaciglicerol aciltransferase 2 (dgat2), composição, e seus usos |
| WO2017011286A1 (en) | 2015-07-10 | 2017-01-19 | Alnylam Pharmaceuticals, Inc. | Insulin-like growth factor binding protein, acid labile subunit (igfals) and insulin-like growth factor 1 (igf-1) irna compositions and methods of use thereof |
| WO2017010575A1 (ja) * | 2015-07-16 | 2017-01-19 | 協和発酵キリン株式会社 | β2GPI遺伝子発現抑制核酸複合体 |
| MA43072A (fr) | 2015-07-22 | 2018-05-30 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| HRP20191589T1 (hr) | 2015-08-06 | 2019-12-13 | Hoffmann La Roche | Postupci za pripravu derivata galnac kiseline |
| CN105111119B (zh) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | 一类卤代苯l‑薄荷醇类p2y12受体拮抗剂及其用途 |
| CN105111118B (zh) * | 2015-08-14 | 2017-04-12 | 天津小新医药科技有限公司 | L‑薄荷醇类p2y12受体拮抗剂、制备方法及其用途 |
| EP3334499A4 (en) | 2015-08-14 | 2019-04-17 | University of Massachusetts | BIOACTIVE CONJUGATES FOR THE RELEASE OF OLIGONUCLEOTIDES |
| HK1252479A1 (zh) | 2015-08-24 | 2019-05-24 | Roche Innovation Center Copenhagen A/S | Lna-g方法 |
| KR102866196B1 (ko) | 2015-09-02 | 2025-09-29 | 알닐람 파마슈티칼스 인코포레이티드 | 프로그램된 세포사 1 리간드 1 (PD-L1) iRNA 조성물 및 그의 사용 방법 |
| WO2017053990A1 (en) | 2015-09-24 | 2017-03-30 | The Regents Of The University Of California | Synthetic sphingolipid-like molecules, drugs, methods of their synthesis and methods of treatment |
| CN108513588A (zh) | 2015-09-24 | 2018-09-07 | Ionis制药公司 | Kras表达的调节剂 |
| WO2017053720A1 (en) * | 2015-09-25 | 2017-03-30 | Tarveda Therapeutics, Inc. | RNAi CONJUGATES, PARTICLES AND FORMULATIONS THEREOF |
| US10533175B2 (en) | 2015-09-25 | 2020-01-14 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating Ataxin 3 expression |
| EP3353306A4 (en) | 2015-09-25 | 2019-06-05 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| WO2017053995A1 (en) * | 2015-09-25 | 2017-03-30 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| JOP20210043A1 (ar) * | 2015-10-01 | 2017-06-16 | Arrowhead Pharmaceuticals Inc | تراكيب وأساليب لتثبيط تعبير جيني للـ lpa |
| US10577388B2 (en) | 2015-10-02 | 2020-03-03 | Roche Innovation Center Copenhagen A/S | Oligonucleotide conjugation process |
| KR20240033305A (ko) | 2015-10-08 | 2024-03-12 | 아이오니스 파마수티컬즈, 인코포레이티드 | 앤지오텐시노겐 발현 조정을 위한 화합물 및 방법 |
| KR20220105174A (ko) | 2015-10-09 | 2022-07-26 | 유니버시티 오브 사우스앰톤 | 유전자 발현의 조절 및 탈조절된 단백질 발현의 스크리닝 |
| US10955407B2 (en) | 2015-10-22 | 2021-03-23 | Roche Innovation Center Copenhagen A/S | In vitro toxicity screening assay |
| WO2017068087A1 (en) | 2015-10-22 | 2017-04-27 | Roche Innovation Center Copenhagen A/S | Oligonucleotide detection method |
| LT4119569T (lt) | 2015-11-06 | 2024-09-25 | Ionis Pharmaceuticals, Inc. | Konjuguoti priešprasmiai junginiai, skirti panaudoti terapijoje |
| JP7486920B2 (ja) | 2015-11-06 | 2024-05-20 | アイオーニス ファーマシューティカルズ, インコーポレーテッド | アポリポタンパク質(a)発現の調節 |
| PL3377510T3 (pl) * | 2015-11-16 | 2021-05-04 | F. Hoffmann-La Roche Ag | Amidofosforyn klastra GalNAc |
| WO2017096395A1 (en) | 2015-12-04 | 2017-06-08 | Ionis Pharmaceuticals, Inc. | Methods of treating breast cancer |
| WO2017106377A1 (en) | 2015-12-14 | 2017-06-22 | Cold Spring Harbor Laboratory | Antisense oligomers for treatment of autosomal dominant mental retardation-5 and dravet syndrome |
| US11096956B2 (en) | 2015-12-14 | 2021-08-24 | Stoke Therapeutics, Inc. | Antisense oligomers and uses thereof |
| EP3397288A4 (en) | 2015-12-31 | 2019-09-11 | Ionis Pharmaceuticals, Inc. | PROCESS FOR REDUCING ATAXIN-2 EXPRESSION |
| EP3400300A4 (en) | 2016-01-05 | 2019-08-07 | Ionis Pharmaceuticals, Inc. | PROCESS FOR REDUCING LRRK2 EXPRESSION |
| WO2017123696A1 (en) | 2016-01-12 | 2017-07-20 | Interleukin Genetics, Inc. | Methods for predicting response to treatment |
| WO2017131124A1 (ja) | 2016-01-26 | 2017-08-03 | 日産化学工業株式会社 | 一本鎖オリゴヌクレオチド |
| SG11201806372UA (en) * | 2016-01-29 | 2018-08-30 | Kyowa Hakko Kirin Co Ltd | Nucleic acid conjugate |
| HK1258758A1 (zh) * | 2016-01-31 | 2019-11-22 | University Of Massachusetts | 分支的寡核苷酸 |
| IL296377A (en) | 2016-03-07 | 2022-11-01 | Arrowhead Pharmaceuticals Inc | Targeting ligands for therapeutic compounds and uses of same |
| AU2017229778A1 (en) | 2016-03-09 | 2018-08-16 | Ionis Pharmaceuticals, Inc. | Methods and compositions for inhibiting PMP22 expression |
| RU2747822C2 (ru) | 2016-03-14 | 2021-05-14 | Ф. Хоффманн-Ля Рош Аг | Олигонуклеотиды для понижения экспрессии pd-l1 |
| WO2017161168A1 (en) | 2016-03-16 | 2017-09-21 | Ionis Pharmaceuticals, Inc. | Modulation of dyrk1b expression |
| EP3429690A4 (en) | 2016-03-16 | 2019-10-23 | Ionis Pharmaceuticals, Inc. | METHOD FOR MODULATING KEAP1 |
| EP3228326A1 (en) * | 2016-04-05 | 2017-10-11 | Silence Therapeutics GmbH | Nucleic acid linked to a trivalent glycoconjugate |
| MA45478A (fr) * | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
| CA3017532A1 (en) | 2016-04-13 | 2017-10-19 | Ionis Pharmaceuticals, Inc. | Methods for reducing c9orf72 expression |
| US11248019B2 (en) | 2016-04-14 | 2022-02-15 | Hoffmann-La Roche Inc. | Trityl-mono-GalNAc compounds and their use |
| MA45295A (fr) | 2016-04-19 | 2019-02-27 | Alnylam Pharmaceuticals Inc | Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser |
| SG11201809002RA (en) | 2016-04-29 | 2018-11-29 | Univ Nanyang Tech | G-quadruplex-containing antisense oligonucleotides |
| MA45270A (fr) | 2016-05-04 | 2017-11-09 | Wave Life Sciences Ltd | Compositions d'oligonucléotides et procédés associés |
| CA3021994A1 (en) | 2016-05-06 | 2017-11-09 | Brett P. Monia | Glp-1 receptor ligand moiety conjugated oligonucleotides and uses thereof |
| EP3471781A4 (en) | 2016-06-17 | 2020-05-06 | Ionis Pharmaceuticals, Inc. | MODULATION OF GYS1 EXPRESSION |
| MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
| EP3472348B1 (en) | 2016-06-17 | 2022-06-29 | F. Hoffmann-La Roche AG | In vitro nephrotoxicity screening assay |
| WO2017216325A1 (en) | 2016-06-17 | 2017-12-21 | F. Hoffmann-La Roche Ag | In vitro nephrotoxicity screening assay |
| AU2017281497B2 (en) | 2016-06-22 | 2023-04-06 | Proqr Therapeutics Ii B.V. | Single-stranded RNA-editing oligonucleotides |
| CN109415401B (zh) * | 2016-06-30 | 2023-02-03 | 协和麒麟株式会社 | 核酸复合物 |
| CA3030701A1 (en) | 2016-07-11 | 2018-01-18 | Translate Bio Ma, Inc. | Nucleic acid conjugates and uses thereof |
| WO2018013999A1 (en) | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
| MX2019000619A (es) | 2016-07-15 | 2019-08-01 | Ionis Pharmaceuticals Inc | Compuestos y metodos para la modulacion de smn2. |
| WO2018031933A2 (en) | 2016-08-12 | 2018-02-15 | University Of Massachusetts | Conjugated oligonucleotides |
| WO2018035380A1 (en) * | 2016-08-17 | 2018-02-22 | Solstice Biologics, Ltd. | Polynucleotide constructs |
| PL3507366T3 (pl) | 2016-09-01 | 2021-05-04 | Proqr Therapeutics Ii B.V. | Chemicznie modyfikowane jednoniciowe oligonukleotydy edytujące rna |
| CN116942841A (zh) | 2016-09-02 | 2023-10-27 | 箭头药业股份有限公司 | 靶向配体 |
| US20190275171A1 (en) * | 2016-09-23 | 2019-09-12 | Ionis Pharmaceuticals, Inc. | Gene therapy and targeted delivery of conjugated compounds |
| JOP20190065A1 (ar) | 2016-09-29 | 2019-03-28 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن tau |
| WO2018067900A1 (en) | 2016-10-06 | 2018-04-12 | Ionis Pharmaceuticals, Inc. | Method of conjugating oligomeric compounds |
| WO2018081661A1 (en) | 2016-10-27 | 2018-05-03 | California Institute Of Technology | Hdac inhibitor compositions for reactivation of the x chromosome |
| JOP20190104A1 (ar) | 2016-11-10 | 2019-05-07 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير عن atxn3 |
| CN110234763A (zh) * | 2016-11-11 | 2019-09-13 | 詹森生物制药有限公司 | 针对hbv cccdna的寡核苷酸靶向策略 |
| TWI788312B (zh) | 2016-11-23 | 2023-01-01 | 美商阿尼拉製藥公司 | 絲胺酸蛋白酶抑制因子A1 iRNA組成物及其使用方法 |
| CN110177544A (zh) | 2016-11-29 | 2019-08-27 | 普尔泰克健康有限公司 | 用于递送治疗剂的外泌体 |
| US11033570B2 (en) | 2016-12-02 | 2021-06-15 | Cold Spring Harbor Laboratory | Modulation of Lnc05 expression |
| MX2019006803A (es) * | 2016-12-13 | 2019-11-18 | Am Sciences Inc | Composicion farmaceutica para prevenir o tratar la hepatitis b. |
| EP3555292A1 (en) | 2016-12-16 | 2019-10-23 | Alnylam Pharmaceuticals, Inc. | Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions |
| CN108239644B (zh) * | 2016-12-23 | 2021-05-28 | 苏州瑞博生物技术股份有限公司 | 一种小干扰核酸和药物组合物及其用途 |
| US10329620B2 (en) | 2017-01-12 | 2019-06-25 | Cardioforecast Ltd. | Methods and kits for treating cardiovascular disease |
| US20190345495A1 (en) | 2017-01-13 | 2019-11-14 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides for modulating nfkb2 expression |
| US20190345496A1 (en) | 2017-01-13 | 2019-11-14 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides for modulating relb expression |
| EP3568477A1 (en) | 2017-01-13 | 2019-11-20 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides for modulating rela expression |
| EP3568478A1 (en) | 2017-01-13 | 2019-11-20 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides for modulating rel expression |
| WO2018130583A1 (en) | 2017-01-13 | 2018-07-19 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides for modulating nfkb1 expression |
| US11572558B2 (en) | 2017-02-06 | 2023-02-07 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| US11180756B2 (en) * | 2017-03-09 | 2021-11-23 | Ionis Pharmaceuticals | Morpholino modified oligomeric compounds |
| WO2018164275A1 (ja) | 2017-03-10 | 2018-09-13 | 国立研究開発法人国立成育医療研究センター | アンチセンスオリゴヌクレオチドおよび糖原病Ia型予防または治療用組成物 |
| JOP20190215A1 (ar) * | 2017-03-24 | 2019-09-19 | Ionis Pharmaceuticals Inc | مُعدّلات التعبير الوراثي عن pcsk9 |
| CN110520531A (zh) * | 2017-04-05 | 2019-11-29 | 赛伦斯治疗有限责任公司 | 产品和组合物 |
| EP3385272A1 (en) | 2017-04-05 | 2018-10-10 | Silence Therapeutics GmbH | Further novel oligonucleotide-ligand conjugates |
| KR102656438B1 (ko) | 2017-04-11 | 2024-04-12 | 아뷰터스 바이오파마 코포레이션 | 표적화 조성물 |
| KR102720270B1 (ko) | 2017-04-18 | 2024-10-23 | 알닐람 파마슈티칼스 인코포레이티드 | B형 간염 바이러스 (hbv)에 감염된 대상체의 치료 방법 |
| WO2018215049A1 (en) | 2017-05-23 | 2018-11-29 | F. Hoffmann-La Roche Ag | Process for galnac oligonucleotide conjugates |
| WO2018216785A1 (ja) * | 2017-05-26 | 2018-11-29 | 国立研究開発法人国立循環器病研究センター | Pcsk9を標的としたアンチセンス核酸 |
| CN111050806A (zh) * | 2017-06-02 | 2020-04-21 | 波涛生命科学有限公司 | 寡核苷酸组合物及其使用方法 |
| CN120330183A (zh) * | 2017-06-02 | 2025-07-18 | 波涛生命科学有限公司 | 寡核苷酸组合物及其使用方法 |
| EP3599844A4 (en) * | 2017-06-07 | 2021-01-13 | University of Massachusetts | ANTI-ADAM33 OLIGONUCLEOTIDES AND RELATED PROCESSES |
| CN110799647A (zh) | 2017-06-23 | 2020-02-14 | 马萨诸塞大学 | 双尾自递送sirna及相关的方法 |
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| JP7277432B2 (ja) | 2017-07-13 | 2023-05-19 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 乳酸脱水素酵素A(LDHA)iRNA組成物及びその使用方法 |
| AU2018307294B2 (en) | 2017-07-26 | 2025-04-17 | Nissan Chemical Corporation | Single-stranded oligonucleotide |
| TW201909925A (zh) * | 2017-08-02 | 2019-03-16 | 日商協和醱酵麒麟有限公司 | 核酸複合體 |
| WO2019027009A1 (ja) * | 2017-08-02 | 2019-02-07 | 協和発酵キリン株式会社 | 核酸複合体 |
| WO2019030313A2 (en) | 2017-08-11 | 2019-02-14 | Roche Innovation Center Copenhagen A/S | OLIGONUCLEOTIDES FOR MODULATION OF UBE3C EXPRESSION |
| WO2019036612A1 (en) | 2017-08-17 | 2019-02-21 | Alnylam Pharmaceuticals, Inc. | ADJUSTABLE REVERSIR TM COMPOUNDS |
| WO2019036613A1 (en) | 2017-08-18 | 2019-02-21 | Ionis Pharmaceuticals, Inc. | MODULATION OF THE NOTCH SIGNALING PATHWAY FOR THE TREATMENT OF RESPIRATORY DISORDERS |
| WO2019038228A1 (en) | 2017-08-22 | 2019-02-28 | Roche Innovation Center Copenhagen A/S | OLIGONUCLEOTIDES FOR MODULATION OF TOM1 EXPRESSION |
| KR20240035631A (ko) | 2017-08-25 | 2024-03-15 | 스톡 테라퓨틱스, 인크. | 병태 및 질환 치료용 안티센스 올리고머 |
| WO2019051173A1 (en) | 2017-09-08 | 2019-03-14 | Ionis Pharmaceuticals, Inc. | MODULATORS OF SMAD7 EXPRESSION |
| EP3682007A2 (en) * | 2017-09-14 | 2020-07-22 | Janssen BioPharma, Inc. | Galnac derivatives |
| AU2018338787C1 (en) | 2017-09-29 | 2025-10-23 | Intellia Therapeutics, Inc. | Compositions and methods for TTR gene editing and treating ATTR amyloidosis |
| AU2018338790B2 (en) | 2017-09-29 | 2022-09-15 | Regeneron Pharmaceuticals, Inc. | Non-human animals comprising a humanized TTR locus and methods of use |
| WO2019073018A1 (en) | 2017-10-13 | 2019-04-18 | Roche Innovation Center Copenhagen A/S | METHODS OF IDENTIFYING ANTISENSE OLIGONUCLEOTIDE IMPROVED OLIGONUCLEOTIDE PHOSPHOROTHIOATE STEREODEFINIS VARIANTS USING PARTIALLY STEREODEFINIS OLIGONUCLEOTIDE SUB LIBRARIES |
| TW202424191A (zh) | 2017-10-16 | 2024-06-16 | 瑞士商赫孚孟拉羅股份公司 | 用於降低PAPD5及PAPD7 mRNA以治療B型肝炎感染之核酸分子 |
| WO2019089922A1 (en) | 2017-11-01 | 2019-05-09 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof |
| TWI809004B (zh) | 2017-11-09 | 2023-07-21 | 美商Ionis製藥公司 | 用於降低snca表現之化合物及方法 |
| EP3710587A1 (en) | 2017-11-16 | 2020-09-23 | Alnylam Pharmaceuticals, Inc. | Kisspeptin 1 (kiss1) irna compositions and methods of use thereof |
| EP3714054A1 (en) | 2017-11-20 | 2020-09-30 | Alnylam Pharmaceuticals, Inc. | Serum amyloid p component (apcs) irna compositions and methods of use thereof |
| CN110945130B (zh) * | 2017-12-01 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN111050807B (zh) * | 2017-12-01 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| WO2019105403A1 (zh) * | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN110997919B (zh) | 2017-12-01 | 2024-04-02 | 苏州瑞博生物技术股份有限公司 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
| HRP20250192T1 (hr) | 2017-12-01 | 2025-04-11 | Suzhou Ribo Life Science Co., Ltd. | Nukleinska kiselina, sastav i konjugat koji je sadrži, te metoda pripreme i uporaba |
| CN110997917B (zh) * | 2017-12-01 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN110944675B9 (zh) * | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| US20200385714A1 (en) | 2017-12-11 | 2020-12-10 | Roche Innovation Center Copenhagen A/S | Oligonucleotides for modulating fndc3b expression |
| WO2019115417A2 (en) | 2017-12-12 | 2019-06-20 | Roche Innovation Center Copenhagen A/S | Oligonucleotides for modulating rb1 expression |
| US11725208B2 (en) | 2017-12-14 | 2023-08-15 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EA202091520A1 (ru) | 2017-12-18 | 2020-10-05 | Элнилэм Фармасьютикалз, Инк. | Композиции на основе irna против бокса-1 высокомобильной группы (hmgb1) и способы их применения |
| WO2019126641A2 (en) | 2017-12-21 | 2019-06-27 | Ionis Pharmaceuticals, Inc. | Modulation of frataxin expression |
| JP2021507253A (ja) | 2017-12-21 | 2021-02-22 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Htra1 rnaアンタゴニストについてのコンパニオン診断 |
| CN111448317B (zh) | 2017-12-22 | 2025-07-04 | 罗氏创新中心哥本哈根有限公司 | 包含二硫代磷酸酯核苷间键的缺口聚物寡核苷酸 |
| EP4092118A1 (en) | 2017-12-22 | 2022-11-23 | Roche Innovation Center Copenhagen A/S | Novel thiophosphoramidites |
| CN111757936B (zh) | 2017-12-22 | 2025-07-04 | 罗氏创新中心哥本哈根有限公司 | 包含二硫代磷酸酯核苷间连接的寡核苷酸 |
| CN109957566B (zh) * | 2017-12-26 | 2023-08-25 | 广州市锐博生物科技有限公司 | 修饰的寡核苷酸和可用于合成修饰的寡核苷酸的化合物 |
| WO2019127004A1 (zh) | 2017-12-26 | 2019-07-04 | 广州市锐博生物科技有限公司 | 修饰的寡核苷酸和可用于合成修饰的寡核苷酸的化合物 |
| CN116375774B (zh) * | 2017-12-29 | 2025-09-23 | 苏州瑞博生物技术股份有限公司 | 缀合物及其制备方法和用途 |
| JP2021511022A (ja) | 2018-01-10 | 2021-05-06 | ロシュ イノベーション センター コペンハーゲン エーエス | Pias4発現を調節するためのオリゴヌクレオチド |
| EP3737424A4 (en) * | 2018-01-10 | 2021-10-27 | Translate Bio MA, Inc. | COMPOSITIONS AND METHODS TO FACILITATE THE DELIVERY OF SYNTHETIC NUCLEIC ACIDS INTO CELLS |
| CA3085964A1 (en) | 2018-01-12 | 2019-07-18 | Roche Innovation Center Copenhagen A/S | Alpha-synuclein antisense oligonucleotides and uses thereof |
| EP3737387A1 (en) | 2018-01-12 | 2020-11-18 | Bristol-Myers Squibb Company | Antisense oligonucleotides targeting alpha-synuclein and uses thereof |
| BR112020014011A2 (pt) | 2018-01-12 | 2020-12-08 | Bristol-Myers Squibb Company | Oligonucleotídeos antissenso dirigidos à alfa-sinucleína e usos dos mesmos |
| WO2019137974A1 (en) | 2018-01-12 | 2019-07-18 | Roche Innovation Center Copenhagen A/S | Oligonucleotides for modulating gsk3b expression |
| MX2020007369A (es) | 2018-01-15 | 2020-10-28 | Ionis Pharmaceuticals Inc | Moduladores de la expresion de dnm2. |
| EP3740574A1 (en) | 2018-01-17 | 2020-11-25 | Roche Innovation Center Copenhagen A/S | Oligonucleotides for modulating erc1 expression |
| US20210095277A1 (en) | 2018-01-18 | 2021-04-01 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting srebp1 |
| WO2019145386A1 (en) | 2018-01-26 | 2019-08-01 | Roche Innovation Center Copenhagen A/S | Oligonucleotides for modulating csnk1d expression |
| AU2019218987B2 (en) | 2018-02-12 | 2025-04-24 | Ionis Pharmaceuticals, Inc. | Modified compounds and uses thereof |
| WO2019161105A1 (en) | 2018-02-14 | 2019-08-22 | Deep Genomics Incorporated | Oligonucleotide therapy for wilson disease |
| JP7500426B2 (ja) | 2018-02-21 | 2024-06-17 | ブリストル-マイヤーズ スクイブ カンパニー | Camk2dアンチセンスオリゴヌクレオチドおよびその使用 |
| WO2019169243A1 (en) | 2018-03-02 | 2019-09-06 | Ionis Pharmaceuticals, Inc. | Compounds and methods for the modulation of amyloid-beta precursor protein |
| TWI840345B (zh) | 2018-03-02 | 2024-05-01 | 美商Ionis製藥公司 | Irf4表現之調節劑 |
| KR102398295B1 (ko) | 2018-03-09 | 2022-05-17 | 다이이찌 산쿄 가부시키가이샤 | 당원병 Ia형 치료약 |
| US11661601B2 (en) | 2018-03-22 | 2023-05-30 | Ionis Pharmaceuticals, Inc. | Methods for modulating FMR1 expression |
| MX2020010383A (es) | 2018-04-05 | 2020-12-10 | Hoffmann La Roche | Uso de inhibidores de fubp1 para el tratamiento de infeccion de virus de hepatitis b. |
| BR112020018698A2 (pt) | 2018-04-11 | 2021-01-05 | Ionis Pharmaceuticals, Inc. | Moduladores de expressão de ezh2 |
| WO2019213016A1 (en) | 2018-04-30 | 2019-11-07 | The Children's Hospital Of Philadelphia | Methods of improving anemias by combining agents |
| WO2019213525A1 (en) | 2018-05-04 | 2019-11-07 | Stoke Therapeutics, Inc. | Methods and compositions for treatment of cholesteryl ester storage disease |
| CN112105745A (zh) | 2018-05-07 | 2020-12-18 | 罗氏创新中心哥本哈根有限公司 | 用于寡核苷酸治疗剂的大规模平行发现方法 |
| EP3790972A1 (en) | 2018-05-08 | 2021-03-17 | Regulus Therapeutics Inc. | Galnac conjugated modified oligonucleotide as mir-122 inhibitor having hcv antiviral activity with reduced hyperbilirubinemia side-effect |
| US11434488B2 (en) | 2018-05-09 | 2022-09-06 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing ATXN3 expression |
| JOP20200280A1 (ar) | 2018-05-09 | 2020-11-05 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير الوراثي عن fxi |
| US12391942B2 (en) | 2018-05-11 | 2025-08-19 | Wave Life Sciences Ltd. | Oligonucleotide compositions and methods of use thereof |
| TWI851574B (zh) | 2018-05-14 | 2024-08-11 | 美商阿尼拉製藥公司 | 血管收縮素原(AGT)iRNA組成物及其使用方法 |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| AU2019287635A1 (en) | 2018-06-14 | 2020-12-17 | Ionis Pharmaceuticals, Inc. | Compounds and methods for increasing STMN2 expression |
| TWI833770B (zh) | 2018-06-27 | 2024-03-01 | 美商Ionis製藥公司 | 用於減少 lrrk2 表現之化合物及方法 |
| US11279929B2 (en) | 2018-07-03 | 2022-03-22 | Hoffmann-La Roche, Inc. | Oligonucleotides for modulating Tau expression |
| WO2020007826A1 (en) | 2018-07-05 | 2020-01-09 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting mbtps1 |
| WO2020011745A2 (en) | 2018-07-11 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting cers6 |
| WO2020011744A2 (en) | 2018-07-11 | 2020-01-16 | Roche Innovation Center Copenhagen A/S | Antisense oligonucleotides targeting cers5 |
| CR20210015A (es) | 2018-07-13 | 2021-03-22 | Hoffmann La Roche | Oligonucleótidos para modular la expresión de rtel 1 |
| EP3823725A4 (en) | 2018-07-17 | 2023-05-10 | Aronora, Inc. | METHODS FOR SAFELY REDUCING THROMBOPOIETIN |
| EA202190299A1 (ru) | 2018-07-25 | 2021-06-11 | Ионис Фармасьютикалз, Инк. | Соединения и способы для снижения экспрессии atxn2 |
| WO2020025563A1 (en) | 2018-07-31 | 2020-02-06 | Roche Innovation Center Copenhagen A/S | Oligonucleotides comprising a phosphorotrithioate internucleoside linkage |
| CN112236439A (zh) | 2018-07-31 | 2021-01-15 | 罗氏创新中心哥本哈根有限公司 | 包含三硫代磷酸酯核苷间键的寡核苷酸 |
| WO2020033748A1 (en) | 2018-08-08 | 2020-02-13 | Arcturus Therapeutics, Inc. | Compositions and agents against nonalcoholic steatohepatitis |
| CN112805383A (zh) | 2018-08-10 | 2021-05-14 | 马萨诸塞大学 | 靶向snp的修饰的寡核苷酸 |
| EP3837366A1 (en) | 2018-08-13 | 2021-06-23 | Alnylam Pharmaceuticals, Inc. | Hepatitis b virus (hbv) dsrna agent compositions and methods of use thereof |
| WO2020038377A1 (zh) | 2018-08-21 | 2020-02-27 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的药物组合物和缀合物及其用途 |
| US11279930B2 (en) | 2018-08-23 | 2022-03-22 | University Of Massachusetts | O-methyl rich fully stabilized oligonucleotides |
| US20220160870A1 (en) | 2018-08-28 | 2022-05-26 | Roche Innovation Center Copenhagen A/S | Neoantigen engineering using splice modulating compounds |
| WO2020060986A1 (en) | 2018-09-18 | 2020-03-26 | Alnylam Pharmaceuticals, Inc. | Ketohexokinase (khk) irna compositions and methods of use thereof |
| TWI869213B (zh) | 2018-09-19 | 2025-01-01 | 美商Ionis製藥公司 | Pnpla3表現之調節劑 |
| CN111655297A (zh) * | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
| WO2020077390A1 (en) * | 2018-10-18 | 2020-04-23 | Murdoch University | Antisense therapy for ptp1b related conditions |
| US10913951B2 (en) | 2018-10-31 | 2021-02-09 | University of Pittsburgh—of the Commonwealth System of Higher Education | Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure |
| AU2019377275A1 (en) | 2018-11-09 | 2021-03-25 | Novartis Ag | Method for reducing the risk of a cardiovascular event with conjugated antisense compounds targeting apo(a) |
| TW202028222A (zh) | 2018-11-14 | 2020-08-01 | 美商Ionis製藥公司 | Foxp3表現之調節劑 |
| KR20210092761A (ko) | 2018-11-15 | 2021-07-26 | 아이오니스 파마수티컬즈, 인코포레이티드 | Irf5 발현 조절인자 |
| EP3884053A4 (en) | 2018-11-21 | 2023-02-01 | Ionis Pharmaceuticals, Inc. | COMPOUNDS AND METHODS FOR REDUCING PRION EXPRESSION |
| CN113166760A (zh) | 2018-11-23 | 2021-07-23 | 赛诺菲 | 用于抑制angptl8的新型rna组合物和方法 |
| AU2019390097A1 (en) | 2018-11-30 | 2021-07-15 | Kyowa Kirin Co., Ltd. | Nucleic acid conjugate |
| EP3894559A4 (en) | 2018-12-03 | 2023-04-05 | Triplet Therapeutics, Inc. | METHODS OF TREATMENT OF TRINUCLEOTIDE REPEAT EXPANSION DISORDERS RELATED TO MLH3 ACTIVITY |
| WO2020132521A1 (en) | 2018-12-20 | 2020-06-25 | Praxis Precision Medicines, Inc. | Compositions and methods for the treatment of kcnt1 related disorders |
| JP7394137B2 (ja) | 2018-12-21 | 2023-12-07 | アイオニス・ファーマシューティカルズ・インコーポレイテッド | Hsd17b13発現のモジュレータ |
| GB201821269D0 (en) | 2018-12-28 | 2019-02-13 | Nippon Shinyaku Co Ltd | Myostatin signal inhibitor |
| US12496347B2 (en) | 2018-12-28 | 2025-12-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| CN111377985B (zh) * | 2018-12-29 | 2023-11-10 | 苏州瑞博生物技术股份有限公司 | 化合物和缀合物及其制备方法和用途 |
| EP3911747A4 (en) | 2019-01-18 | 2023-05-24 | University Of Massachusetts | DYNAMIC PHARMACOKINETICS-MODIFYING ANCHORS |
| CN113330117B (zh) * | 2019-01-18 | 2024-05-28 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CN113395971A (zh) | 2019-01-31 | 2021-09-14 | Ionis制药公司 | Yap1表达的调节剂 |
| EP3927716A1 (en) | 2019-02-20 | 2021-12-29 | Roche Innovation Center Copenhagen A/S | Novel phosphoramidites |
| MX2021009950A (es) | 2019-02-20 | 2021-09-21 | Roche Innovation Ct Copenhagen As | Oligonucleotidos gapmeros de fosfonoacetato. |
| CN109799330B (zh) * | 2019-02-22 | 2021-03-02 | 华中科技大学同济医学院附属同济医院 | 神经氨酸及神经氨酸酶抑制剂在慢性心力衰竭中的应用 |
| WO2020173845A1 (en) | 2019-02-26 | 2020-09-03 | Roche Innovation Center Copenhagen A/S | Oligonucleotide formulation method |
| WO2020176771A1 (en) | 2019-02-27 | 2020-09-03 | Ionis Pharmaceuticals, Inc. | Modulators of malat1 expression |
| WO2020172755A1 (en) * | 2019-02-28 | 2020-09-03 | Deep Genomics Incorporated | Ligand clusters and methods of their use and preparation |
| AU2020242043A1 (en) * | 2019-03-21 | 2021-10-14 | Mitotherapeutix Llc | Multivalent ligand clusters for targeted delivery of therapeutic agents |
| MX2021011916A (es) | 2019-03-29 | 2021-10-26 | Ionis Pharmaceuticals Inc | Compuestos y metodos para modular ube3a-ats. |
| CA3132178A1 (en) | 2019-04-02 | 2020-10-08 | Aliye Seda Yilmaz-Elis | Antisense oligonucleotides for immunotherapy |
| EP3947680A2 (en) | 2019-04-03 | 2022-02-09 | Bristol-Myers Squibb Company | Angptl2 antisense oligonucleotides and uses thereof |
| US20220251128A1 (en) * | 2019-05-17 | 2022-08-11 | Ionis Pharmaceuticals, Inc. | Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphodiester linkages |
| CN113811613B (zh) | 2019-05-22 | 2024-04-05 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| TWI863999B (zh) | 2019-05-22 | 2024-12-01 | 大陸商蘇州瑞博生物技術股份有限公司 | siRNA綴合物、其用途及使用其之方法 |
| CN113227376B (zh) * | 2019-05-22 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| EP3974530A4 (en) | 2019-05-22 | 2023-07-12 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, PHARMACEUTICAL COMPOSITION, CONJUGATE, METHOD FOR PREPARATION AND USE |
| CN113795582B (zh) | 2019-05-24 | 2024-05-24 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| CN113891939B (zh) | 2019-05-24 | 2024-04-02 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| WO2020238763A1 (zh) | 2019-05-24 | 2020-12-03 | 苏州瑞博生物技术股份有限公司 | 核酸、药物组合物与缀合物及制备方法和用途 |
| TW202111123A (zh) | 2019-05-28 | 2021-03-16 | 美商Ionis製藥公司 | 用於減少fus 表現之化合物及方法 |
| AU2020282828A1 (en) | 2019-05-31 | 2022-01-27 | Aligos Therapeutics, Inc. | Modified gapmer oligonucleotides and methods of use |
| KR20220016869A (ko) | 2019-06-04 | 2022-02-10 | 리제너론 파마슈티칼스 인코포레이티드 | 베타-슬립 돌연변이를 갖는 인간화 ttr 좌위를 포함하는 비-인간 동물 및 사용 방법 |
| AU2020301419A1 (en) | 2019-06-25 | 2022-01-20 | Amgen Inc. | Purification methods for carbohydrate-linked oligonucleotides |
| EP4660307A2 (en) | 2019-07-26 | 2025-12-10 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating gfap |
| WO2021022108A2 (en) | 2019-08-01 | 2021-02-04 | Alnylam Pharmaceuticals, Inc. | CARBOXYPEPTIDASE B2 (CPB2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| EP4007812A1 (en) | 2019-08-01 | 2022-06-08 | Alnylam Pharmaceuticals, Inc. | Serpin family f member 2 (serpinf2) irna compositions and methods of use thereof |
| KR20220047989A (ko) | 2019-08-09 | 2022-04-19 | 유니버시티 오브 매사추세츠 | Snp를 표적화하는 화학적으로 변형된 올리고뉴클레오타이드 |
| EP4013870A1 (en) | 2019-08-13 | 2022-06-22 | Alnylam Pharmaceuticals, Inc. | Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof |
| EP4013767A4 (en) * | 2019-08-15 | 2023-10-25 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds and uses thereof |
| EP4022061A1 (en) | 2019-08-27 | 2022-07-06 | Sanofi | Compositions and methods for inhibiting pcsk9 |
| TW202122093A (zh) | 2019-08-29 | 2021-06-16 | 大陸商蘇州瑞博生物技術股份有限公司 | 化合物、藥物綴合物、試劑盒及其用途 |
| EP4022062A1 (en) | 2019-08-30 | 2022-07-06 | Alnylam Pharmaceuticals, Inc. | Neurofilament light chain (nfl) as a biomarker for transthyretin amyloidosis polyneuropathy |
| CN114929282B (zh) * | 2019-09-03 | 2025-09-19 | 阿克丘勒斯治疗公司 | 脱唾液酸糖蛋白受体介导的治疗活性缀合物的递送 |
| KR20220061972A (ko) | 2019-09-10 | 2022-05-13 | 다이이찌 산쿄 가부시키가이샤 | 간장 송달용 GalNAc-올리고뉴클레오티드 콘주게이트 및 제조 방법 |
| US12365894B2 (en) | 2019-09-16 | 2025-07-22 | University Of Massachusetts | Branched lipid conjugates of siRNA for specific tissue delivery |
| JP2022548652A (ja) | 2019-09-20 | 2022-11-21 | エフ.ホフマン-ラ ロシュ アーゲー | コアタンパク質アロステリックモジュレータを使用してhbv感染を処置する方法 |
| EP4038189A1 (en) | 2019-10-04 | 2022-08-10 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for silencing ugt1a1 gene expression |
| EP4045062A1 (en) | 2019-10-14 | 2022-08-24 | Astrazeneca AB | Modulators of pnpla3 expression |
| US12486512B2 (en) | 2019-10-18 | 2025-12-02 | Alnylam Pharmaceuticals, Inc. | Solute carrier family member iRNA compositions and methods of use thereof |
| MX2022004726A (es) | 2019-10-22 | 2022-05-13 | Alnylam Pharmaceuticals Inc | Composiciones de acido ribonucleico de interferencia (arni) de componente c3 de complemento y metodos de uso de las mismas. |
| MX2022004388A (es) | 2019-11-01 | 2022-05-06 | Alnylam Pharmaceuticals Inc | Composiciones de agentes de arni de huntingtina (htt) y metodos de uso de las mismas. |
| TW202526019A (zh) | 2019-11-13 | 2025-07-01 | 美商阿尼拉製藥公司 | 用於治療血管收縮素原相關病症之方法及組成物 |
| US20230056569A1 (en) | 2019-11-22 | 2023-02-23 | Alnylam Pharmaceuticals, Inc. | Ataxin3 (atxn3) rnai agent compositions and methods of use thereof |
| CN112876534B (zh) * | 2019-11-29 | 2024-02-09 | 苏州瑞博生物技术股份有限公司 | 肝靶向化合物及缀合物 |
| MX2022006433A (es) | 2019-12-13 | 2022-06-23 | Alnylam Pharmaceuticals Inc | Composiciones de agentes de acido ribonucleico de interferencia (arni) del marco de lectura abierto 72 del cromosoma 9 humano (c9orf72) y metodos de uso de los mismos. |
| WO2021126734A1 (en) | 2019-12-16 | 2021-06-24 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| CN111041025B (zh) * | 2019-12-17 | 2021-06-18 | 深圳市瑞吉生物科技有限公司 | 基于结合N-乙酰半乳糖胺多肽的mRNA靶向分子及其制备方法 |
| CN114867856A (zh) | 2019-12-19 | 2022-08-05 | 豪夫迈·罗氏有限公司 | Saraf抑制剂用于治疗乙型肝炎病毒感染的用途 |
| JP2023506540A (ja) | 2019-12-19 | 2023-02-16 | エフ. ホフマン-ラ ロシュ エージー. | B型肝炎ウイルス感染を処置するためのscamp3阻害剤の使用 |
| EP4077667A1 (en) | 2019-12-19 | 2022-10-26 | F. Hoffmann-La Roche AG | Use of sept9 inhibitors for treating hepatitis b virus infection |
| EP4077670A1 (en) | 2019-12-19 | 2022-10-26 | F. Hoffmann-La Roche AG | Use of cops3 inhibitors for treating hepatitis b virus infection |
| WO2021122910A1 (en) | 2019-12-19 | 2021-06-24 | F. Hoffmann-La Roche Ag | Use of sbds inhibitors for treating hepatitis b virus infection |
| AU2020415322A1 (en) | 2019-12-24 | 2022-06-16 | F. Hoffmann-La Roche Ag | Pharmaceutical combination of antiviral agents targeting HBV and/or an immune modulator for treatment of HBV |
| WO2021130195A1 (en) | 2019-12-24 | 2021-07-01 | F. Hoffmann-La Roche Ag | Method of treating virus infection using a tlr7 agonist |
| MX2022007908A (es) | 2019-12-24 | 2022-07-21 | Hoffmann La Roche | Combinacion farmaceutica de un oligonucleotido terapeutico que actua sobre hbv y un agonista de tlr7 para el tratamiento de hbv. |
| TWI877296B (zh) * | 2020-01-30 | 2025-03-21 | 日商衛材R&D企管股份有限公司 | 核酸複合體及包含其之醫藥組合物 |
| AU2021220765A1 (en) | 2020-02-10 | 2022-09-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for silencing VEGF-A expression |
| AU2021224778A1 (en) | 2020-02-18 | 2022-09-29 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein C3 (APOC3) iRNA compositions and methods of use thereof |
| TW202517787A (zh) | 2020-02-28 | 2025-05-01 | 美商Ionis製藥公司 | 用於調節smn2之化合物及方法 |
| GB2627637B (en) | 2020-03-04 | 2024-11-20 | Verve Therapeutics Inc | A method for reducing the risk of coronary disease |
| EP4114947A1 (en) | 2020-03-05 | 2023-01-11 | Alnylam Pharmaceuticals, Inc. | Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases |
| JP2023516095A (ja) | 2020-03-06 | 2023-04-17 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | ケトヘキソキナーゼ(KHK)iRNA組成物およびその使用方法 |
| CA3174473A1 (en) | 2020-03-06 | 2021-09-10 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin (ttr) |
| WO2021188611A1 (en) | 2020-03-18 | 2021-09-23 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant |
| EP4126967A1 (en) | 2020-03-23 | 2023-02-08 | Amgen Inc. | Monoclonal antibodies to chemically-modified nucleic acids and uses thereof |
| WO2021193965A1 (ja) * | 2020-03-26 | 2021-09-30 | 国立研究開発法人国立循環器病研究センター | Apoc3を標的としたアンチセンス核酸 |
| EP4127168A1 (en) | 2020-03-26 | 2023-02-08 | Alnylam Pharmaceuticals, Inc. | Coronavirus irna compositions and methods of use thereof |
| WO2021207167A1 (en) | 2020-04-06 | 2021-10-14 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for silencing myoc expression |
| WO2021206922A1 (en) | 2020-04-07 | 2021-10-14 | Alnylam Pharmaceuticals, Inc. | Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof |
| WO2021206917A1 (en) | 2020-04-07 | 2021-10-14 | Alnylam Pharmaceuticals, Inc. | ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| CA3179678A1 (en) | 2020-04-07 | 2021-10-14 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for silencing scn9a expression |
| CN115916219A (zh) | 2020-04-21 | 2023-04-04 | 旗舰创业股份有限公司 | 双官能分子及其使用方法 |
| WO2021222065A1 (en) | 2020-04-27 | 2021-11-04 | Alnylam Pharmaceuticals, Inc. | Apolipoprotein e (apoe) irna agent compositions and methods of use thereof |
| CN111575279A (zh) * | 2020-04-27 | 2020-08-25 | 江苏为真生物医药技术股份有限公司 | 利用asgpr小分子配体特异性捕获肝细胞外囊泡或循环肿瘤细胞的方法 |
| IL297680A (en) | 2020-04-30 | 2022-12-01 | Alnylam Pharmaceuticals Inc | Complement factor b (cfb) irna compositions and methods of use thereof |
| BR112022021333A2 (pt) | 2020-05-01 | 2022-12-13 | Ionis Pharmaceuticals Inc | Compostos e métodos para modular atxn1 |
| KR20230022409A (ko) | 2020-05-11 | 2023-02-15 | 스톡 테라퓨틱스, 인크. | 병태 및 질환의 치료를 위한 opa1 안티센스 올리고머 |
| EP4150077A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1) |
| EP4150086A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2) |
| WO2021231680A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2) |
| EP4150090A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of otoferlin (otof) |
| WO2021231698A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl) |
| WO2021231691A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of retinoschisin 1 (rsi) |
| WO2021231675A1 (en) | 2020-05-15 | 2021-11-18 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1) |
| EP4150087A1 (en) | 2020-05-15 | 2023-03-22 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2) |
| CN113683651A (zh) * | 2020-05-19 | 2021-11-23 | 上海京新生物医药有限公司 | 一种GalNAc中间体的制备方法 |
| AR122534A1 (es) | 2020-06-03 | 2022-09-21 | Triplet Therapeutics Inc | Métodos para el tratamiento de los trastornos de expansión por repetición de nucleótidos asociados con la actividad de msh3 |
| EP4162050A1 (en) | 2020-06-09 | 2023-04-12 | Alnylam Pharmaceuticals, Inc. | Rnai compositions and methods of use thereof for delivery by inhalation |
| US20230203496A1 (en) | 2020-06-09 | 2023-06-29 | Alnylam Pharmaceuticals, Inc. | Sirna compositions and methods for silencing gpam (glycerol-3-phosphate acyltransferase 1, mitochondrial) expression |
| US20240033278A9 (en) * | 2020-06-10 | 2024-02-01 | Medshine Discovery Inc. | Conjugate group and conjugate |
| TW202214856A (zh) | 2020-06-18 | 2022-04-16 | 美商阿尼拉製藥公司 | 黃嘌呤脫氫酶(XDH)iRNA組成物及其使用之方法 |
| ES3002193T3 (en) * | 2020-06-24 | 2025-03-06 | Sapreme Tech Bv | Conjugate of galnac and saponin, therapeutic composition comprising said conjugate and a galnac-oligonucleotide conjugate |
| AR122731A1 (es) | 2020-06-26 | 2022-10-05 | Hoffmann La Roche | Oligonucleótidos mejorados para modular la expresión de fubp1 |
| CN116096899A (zh) | 2020-06-29 | 2023-05-09 | Ionis制药公司 | 调节plp1的化合物和方法 |
| CN111744019B (zh) | 2020-07-01 | 2023-08-04 | 深圳瑞吉生物科技有限公司 | 基于甘露糖的mRNA靶向递送系统及其应用 |
| KR20230050336A (ko) | 2020-07-10 | 2023-04-14 | 인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸) | 뇌전증을 치료하기 위한 방법과 조성물 |
| UY39344A (es) | 2020-07-28 | 2022-02-25 | Ionis Pharmaceuticals Inc | Compuestos y métodos para reducir la expresión de app |
| CN116322707A (zh) | 2020-08-07 | 2023-06-23 | 艾欧尼斯制药公司 | 用于调节scn2a的化合物和方法 |
| EP4196584A2 (en) * | 2020-08-13 | 2023-06-21 | Amgen Inc. | Rnai constructs and methods for inhibiting marc1 expression |
| WO2022038211A2 (en) | 2020-08-21 | 2022-02-24 | F. Hoffmann-La Roche Ag | Use of a1cf inhibitors for treating hepatitis b virus infection |
| EP4217489A1 (en) | 2020-09-24 | 2023-08-02 | Alnylam Pharmaceuticals, Inc. | Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof |
| WO2022076291A1 (en) | 2020-10-05 | 2022-04-14 | Alnylam Pharmaceuticals, Inc. | G protein-coupled receptor 75 (gpr75) irna compositions and methods of use thereof |
| CN116490195A (zh) | 2020-10-16 | 2023-07-25 | 赛诺菲 | 用于抑制脂蛋白(a)的RNA组合物和方法 |
| WO2022079222A1 (en) | 2020-10-16 | 2022-04-21 | Sanofi | Novel rna compositions and methods for inhibiting angptl3 |
| WO2022087329A1 (en) | 2020-10-23 | 2022-04-28 | Alnylam Pharmaceuticals, Inc. | Mucin 5b (muc5b) irna compositions and methods of use thereof |
| IL302709A (en) | 2020-11-13 | 2023-07-01 | Alnylam Pharmaceuticals Inc | Coagulation factor iRNA compositions (F5) and methods of using them |
| EP4488371A3 (en) | 2020-11-18 | 2025-04-09 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating angiotensinogen expression |
| WO2022106695A1 (en) | 2020-11-23 | 2022-05-27 | Alpha Anomeric Sas | Nucleic acid duplexes |
| EP4259795A1 (en) | 2020-12-08 | 2023-10-18 | Alnylam Pharmaceuticals, Inc. | Coagulation factor x (f10) irna compositions and methods of use thereof |
| GB2603454A (en) | 2020-12-09 | 2022-08-10 | Ucl Business Ltd | Novel therapeutics for the treatment of neurodegenerative disorders |
| WO2022133278A2 (en) | 2020-12-18 | 2022-06-23 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating factor xii |
| US20250304966A1 (en) | 2020-12-23 | 2025-10-02 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| CN116669746B (zh) | 2020-12-29 | 2025-09-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途 |
| WO2022150260A1 (en) | 2021-01-05 | 2022-07-14 | Alnylam Pharmaceuticals, Inc. | COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF |
| WO2022162161A1 (en) * | 2021-01-30 | 2022-08-04 | E-Therapeutics Plc | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| WO2022162157A1 (en) * | 2021-01-30 | 2022-08-04 | E-Therapeutics Plc | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| CN116848127A (zh) * | 2021-01-30 | 2023-10-03 | e-生物有限公司 | 缀合寡核苷酸化合物、其制备方法和用途 |
| CA3204317A1 (en) * | 2021-01-30 | 2022-08-04 | Ahmad Ali MORTAZAVI | Conjugated oligonucleotide compounds, methods of making and uses thereof |
| CN117355534A (zh) * | 2021-01-30 | 2024-01-05 | e-生物有限公司 | 缀合寡核苷酸化合物、其制备方法和用途 |
| JP2024504505A (ja) * | 2021-01-30 | 2024-01-31 | イー セラピューティクス パブリック リミテッド カンパニー | コンジュゲートオリゴヌクレオチド化合物、その作製方法及び使用 |
| TW202246500A (zh) | 2021-02-02 | 2022-12-01 | 瑞士商赫孚孟拉羅股份公司 | 用於抑制 rtel1 表現之增強型寡核苷酸 |
| CA3210763A1 (en) | 2021-02-12 | 2022-08-18 | Alnylam Pharmaceuticals, Inc. | Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases |
| CN117222434A (zh) * | 2021-02-18 | 2023-12-12 | 强新科技集团 | 缀合寡核苷酸和碳水化合物的新组合物 |
| WO2022182864A1 (en) | 2021-02-25 | 2022-09-01 | Alnylam Pharmaceuticals, Inc. | Prion protein (prnp) irna compositions and methods and methods of use thereof |
| IL305153A (en) | 2021-02-26 | 2023-10-01 | Alnylam Pharmaceuticals Inc | Ketohexokinase (KHK) iRNA compositions and methods of using them |
| AU2022231003A1 (en) | 2021-03-04 | 2023-09-14 | Alnylam Pharmaceuticals, Inc. | Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof |
| CA3212650A1 (en) | 2021-03-08 | 2022-09-15 | Les Laboratoires Servier | Antisense oligonucleotides for inhibiting alpha-synuclein expression |
| WO2022189861A1 (en) | 2021-03-08 | 2022-09-15 | Tollys | Carbohydrate conjugates of tlr3 ligands and uses thereof |
| EP4305169A1 (en) | 2021-03-12 | 2024-01-17 | Alnylam Pharmaceuticals, Inc. | Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof |
| KR20230162024A (ko) | 2021-03-29 | 2023-11-28 | 알닐람 파마슈티칼스 인코포레이티드 | 헌팅틴(HTT) iRNA 제제 조성물 및 이의 사용 방법 |
| EP4314293A1 (en) | 2021-04-01 | 2024-02-07 | Alnylam Pharmaceuticals, Inc. | Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof |
| BR112023021109A2 (pt) | 2021-04-14 | 2023-12-12 | Dicerna Pharmaceuticals Inc | Composições e métodos para modular a expressão de pnpla3 |
| IL307926A (en) | 2021-04-26 | 2023-12-01 | Alnylam Pharmaceuticals Inc | Transmembrane assemblies, serine 6 ((TMPRSS6 IRNA) and methods of using them |
| WO2022232343A1 (en) | 2021-04-29 | 2022-11-03 | Alnylam Pharmaceuticals, Inc. | Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof |
| WO2022232650A1 (en) * | 2021-04-30 | 2022-11-03 | Ionis Pharmaceuticals, Inc. | Methods for reducing agt expression |
| EP4341401A1 (en) | 2021-05-18 | 2024-03-27 | Alnylam Pharmaceuticals, Inc. | Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof |
| WO2022246023A1 (en) | 2021-05-20 | 2022-11-24 | Korro Bio, Inc. | Methods and compositions for adar-mediated editing |
| WO2022256283A2 (en) | 2021-06-01 | 2022-12-08 | Korro Bio, Inc. | Methods for restoring protein function using adar |
| EP4347823A1 (en) | 2021-06-02 | 2024-04-10 | Alnylam Pharmaceuticals, Inc. | Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof |
| BR112023025224A2 (pt) | 2021-06-04 | 2024-02-27 | Alnylam Pharmaceuticals Inc | Quadro de leitura aberto 72 do cromossomo humano 9 (c9orf72) composições de agente de irna e métodos de uso dos mesmos |
| WO2022260939A2 (en) | 2021-06-08 | 2022-12-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for treating or preventing stargardt's disease and/or retinal binding protein 4 (rbp4)-associated disorders |
| US11753644B2 (en) | 2021-06-18 | 2023-09-12 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing IFNAR1 expression |
| AU2022299169A1 (en) | 2021-06-23 | 2024-02-08 | Beth Israel Deaconess Medical Center, Inc. | Optimized anti-flt1 oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders |
| JP2024522852A (ja) * | 2021-06-24 | 2024-06-21 | イーライ リリー アンド カンパニー | 新規治療用送達部分及びその使用 |
| KR20240023630A (ko) * | 2021-06-24 | 2024-02-22 | 일라이 릴리 앤드 캄파니 | 신규 rna 치료제 및 그의 용도 |
| US20230194709A9 (en) | 2021-06-29 | 2023-06-22 | Seagate Technology Llc | Range information detection using coherent pulse sets with selected waveform characteristics |
| EP4363574A1 (en) | 2021-06-29 | 2024-05-08 | Korro Bio, Inc. | Methods and compositions for adar-mediated editing |
| WO2023278576A1 (en) | 2021-06-30 | 2023-01-05 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating an angiotensinogen- (agt-) associated disorder |
| WO2023274395A1 (zh) * | 2021-07-02 | 2023-01-05 | 上海拓界生物医药科技有限公司 | 一种核酸配体及其缀合物、其制备方法和用途 |
| EP4368187A4 (en) | 2021-07-08 | 2025-07-02 | Nippon Shinyaku Co Ltd | PRECIPITATION INHIBITING AGENT |
| WO2023282344A1 (ja) | 2021-07-08 | 2023-01-12 | 日本新薬株式会社 | 腎毒性軽減剤 |
| CN118475355A (zh) | 2021-07-08 | 2024-08-09 | 日本新药株式会社 | 肾毒性减轻剂 |
| TW202333748A (zh) | 2021-07-19 | 2023-09-01 | 美商艾拉倫製藥股份有限公司 | 用於處置具有或有風險發展非原發性高草酸鹽尿疾病或病症的個體的方法及組成物 |
| IL309905A (en) | 2021-07-23 | 2024-03-01 | Alnylam Pharmaceuticals Inc | IRNA compositions in β-catenin (CTNNB1) and methods of using them |
| EP4377458A1 (en) | 2021-07-29 | 2024-06-05 | Alnylam Pharmaceuticals, Inc. | 3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof |
| JP2024530647A (ja) * | 2021-08-03 | 2024-08-23 | ヴァーヴ・セラピューティクス,インコーポレーテッド | 標的rna送達のための組成物および方法 |
| JP2024530018A (ja) | 2021-08-03 | 2024-08-14 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | トランスサイレチン(TTR)iRNA組成物およびその使用方法 |
| EP4381071A1 (en) | 2021-08-04 | 2024-06-12 | Alnylam Pharmaceuticals, Inc. | Irna compositions and methods for silencing angiotensinogen (agt) |
| EP4384617A1 (en) | 2021-08-13 | 2024-06-19 | Alnylam Pharmaceuticals, Inc. | Factor xii (f12) irna compositions and methods of use thereof |
| MX2024002440A (es) | 2021-08-31 | 2024-03-08 | Alnylam Pharmaceuticals Inc | Composiciones de acido ribonucleico de interferencia (arni) del efector b similar al factor de fragmentacion de adn subunidad alfa (dffa) que induce la muerte celular (cideb) y metodos de uso de estas. |
| US20250283076A1 (en) | 2021-09-14 | 2025-09-11 | Argonaute RNA Limited | Treatment of cardiovascular disease |
| EP4401742A2 (en) | 2021-09-17 | 2024-07-24 | Alnylam Pharmaceuticals, Inc. | Irna compositions and methods for silencing complement component 3 (c3) |
| CA3232191A1 (en) * | 2021-09-18 | 2023-03-23 | Chong Li | Lpa inhibitor and use thereof |
| CN118159654A (zh) | 2021-09-20 | 2024-06-07 | 阿尔尼拉姆医药品有限公司 | 抑制素亚基βE(INHBE)调节剂组合物及其使用方法 |
| MX2024003477A (es) * | 2021-09-23 | 2024-04-05 | Shanghai Argo Biopharmaceutical Co Ltd | Cluster de ligandos multivalentes con andamio de diamina para el suministro dirigido de agentes terapeuticos. |
| KR20240067943A (ko) | 2021-09-24 | 2024-05-17 | 알닐람 파마슈티칼스 인코포레이티드 | 미소관 연관 단백질 타우(MAPT) iRNA 제제 조성물 및 이의 사용 방법 |
| WO2023056440A1 (en) | 2021-10-01 | 2023-04-06 | Adarx Pharmaceuticals, Inc. | Prekallikrein-modulating compositions and methods of use thereof |
| AU2022370009A1 (en) | 2021-10-22 | 2024-05-16 | Korro Bio, Inc. | Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing |
| EP4423272A2 (en) | 2021-10-29 | 2024-09-04 | Alnylam Pharmaceuticals, Inc. | Huntingtin (htt) irna agent compositions and methods of use thereof |
| CA3234636A1 (en) | 2021-10-29 | 2023-05-04 | Alnylam Pharmaceuticals, Inc. | Complement factor b (cfb) irna compositions and methods of use thereof |
| JP2024544532A (ja) | 2021-11-11 | 2024-12-03 | エフ. ホフマン-ラ ロシュ アーゲー | Hbvの処置のための医薬組合せ |
| JP2025501682A (ja) | 2021-12-03 | 2025-01-23 | クラリス コーポレーション | 改変された骨格化学を有するギャップマーアンチセンスオリゴヌクレオチド |
| GB202117758D0 (en) | 2021-12-09 | 2022-01-26 | Ucl Business Ltd | Therapeutics for the treatment of neurodegenerative disorders |
| WO2023109935A1 (zh) * | 2021-12-16 | 2023-06-22 | 上海拓界生物医药科技有限公司 | 一种dsRNA、其制备方法及应用 |
| US20250332190A1 (en) * | 2021-12-16 | 2025-10-30 | Tuojie Biotech (Shanghai) Co., Ltd. | Lpa-targeting sirna and conjugate |
| EP4448106A1 (en) | 2021-12-17 | 2024-10-23 | Hoffmann-La Roche Inc. | Combination of oligonucleotides for modulating rtel1 and fubp1 |
| MX2024008804A (es) * | 2022-01-20 | 2024-07-25 | Tuojie Biotech Shanghai Co Ltd | Arnbc, uso y metodo de preparacion para el mismo. |
| TW202345865A (zh) * | 2022-01-24 | 2023-12-01 | 大陸商上海舶望製藥有限公司 | 抑制LPA(Apo(a))蛋白表達的組合物和方法 |
| EP4469575A2 (en) | 2022-01-24 | 2024-12-04 | Alnylam Pharmaceuticals, Inc. | Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof |
| AU2023211407A1 (en) * | 2022-01-30 | 2024-08-15 | Rona Bioscience, Limited | Targeting ligand containing n-acetylgalactosamine |
| AR128558A1 (es) | 2022-02-21 | 2024-05-22 | Hoffmann La Roche | Oligonucleótido antisentido |
| TW202346589A (zh) | 2022-03-10 | 2023-12-01 | 日商日本新藥股份有限公司 | 抗病毒反義寡聚物 |
| CN114703184B (zh) * | 2022-03-11 | 2024-06-18 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
| US20250188477A1 (en) | 2022-03-16 | 2025-06-12 | Daiichi Sankyo Company, Limited | CHEMICALLY MODIFIED OLIGONUCLEOTIDE HAVING RNAi ACTIVITY |
| AU2023234185A1 (en) | 2022-03-16 | 2024-10-03 | Daiichi Sankyo Company, Limited | siRNA FOR SUPPRESSING EXPRESSION OF TRANSFERRIN RECEPTOR-2 |
| TW202400787A (zh) | 2022-03-16 | 2024-01-01 | 美商安彼瑞可股份有限公司 | 改良siRNA生物可利用性之GalNAc組合物 |
| WO2023192830A2 (en) | 2022-03-28 | 2023-10-05 | Empirico Inc. | Modified oligonucleotides |
| CN115028670B (zh) * | 2022-06-24 | 2023-07-28 | 四川大学华西医院 | 一种n-乙酰基-d-半乳糖胺三聚体前体的制备方法 |
| WO2024001172A1 (en) * | 2022-06-27 | 2024-01-04 | Ractigen Therapeutics | Oligonucleotide modulators activating complement factor h expression |
| WO2024013361A1 (en) | 2022-07-15 | 2024-01-18 | Proqr Therapeutics Ii B.V. | Oligonucleotides for adar-mediated rna editing and use thereof |
| EP4555085A1 (en) | 2022-07-15 | 2025-05-21 | ProQR Therapeutics II B.V. | Chemically modified oligonucleotides for adar-mediated rna editing |
| CN116814621B (zh) * | 2022-08-05 | 2025-09-09 | 厦门甘宝利生物医药有限公司 | 一种抑制apoc3基因表达的rna抑制剂及其应用 |
| CN120077130A (zh) | 2022-08-18 | 2025-05-30 | 阿尔尼拉姆医药品有限公司 | 通用非靶向sirna组合物及其使用方法 |
| EP4569113A1 (en) | 2022-09-15 | 2025-06-18 | Regeneron Pharmaceuticals, Inc. | 17b-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof |
| WO2024064858A2 (en) | 2022-09-23 | 2024-03-28 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing mecp2 expression |
| WO2024098061A2 (en) | 2022-11-04 | 2024-05-10 | Genkardia Inc. | Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure |
| EP4619524A1 (en) | 2022-11-18 | 2025-09-24 | Genkardia Inc. | Methods and compositions for preventing, treating, or reversing cardiac diastolic dysfunction |
| WO2024106539A1 (ja) * | 2022-11-18 | 2024-05-23 | 株式会社ボナック | リガンドコンジュゲート物質及びそれを含む核酸並びにその用途 |
| JP2025539851A (ja) * | 2022-11-23 | 2025-12-09 | プレッツェル セラピューティクス,インコーポレイテッド | がん及び代謝疾患の治療のための組成物及び方法 |
| TW202440920A (zh) | 2022-12-02 | 2024-10-16 | 大陸商上海舶望製藥有限公司 | 雙環脫鹼基核酸類似物以及由它們製備的寡聚化合物 |
| CN118984717A (zh) | 2022-12-19 | 2024-11-19 | 昂拓生物医药有限公司 | Arnatar化合物和用于增强细胞摄取的方法 |
| AU2023408479A1 (en) | 2022-12-19 | 2025-05-01 | Arnatar Therapeutics, Inc | Advanced rna targeting (arnatar) |
| AR131419A1 (es) * | 2022-12-21 | 2025-03-19 | Lilly Co Eli | TERAPÉUTICOS NOVEDOSOS DE iARN DE FAS Y USOS DE ESTOS |
| IL321969A (en) * | 2023-01-10 | 2025-09-01 | Ausperbio Therapeutics Inc | Multi-stranded antisense oligonucleotides modified for use |
| WO2024168010A2 (en) | 2023-02-09 | 2024-08-15 | Alnylam Pharmaceuticals, Inc. | Reversir molecules and methods of use thereof |
| CN120752340A (zh) * | 2023-02-24 | 2025-10-03 | 重庆药友制药有限责任公司 | 包合R和E的双链siRNA类似物及其缀合物 |
| CN121285630A (zh) | 2023-04-20 | 2026-01-06 | 阿达尔克斯制药有限公司 | Mapt调节组合物及其使用方法 |
| WO2024220746A2 (en) | 2023-04-21 | 2024-10-24 | Flagship Pioneering Innovations Vii, Llc | Rnai agents targeting fatty acid synthase and related methods |
| WO2024221135A1 (en) * | 2023-04-23 | 2024-10-31 | Ausper Biopharma Co., Ltd. | Oligonucleotides for use in modulating immune responses against hepatitis b viral infection |
| US20240374741A1 (en) * | 2023-05-11 | 2024-11-14 | Synerk Biotech Limited | Compound, a conjugate and uses thereof |
| AU2024273075A1 (en) | 2023-05-12 | 2025-11-20 | Adarx Pharmaceuticals, Inc. | Nmda ligand conjugated compounds and uses thereof |
| UY40743A (es) * | 2023-05-19 | 2024-12-13 | Shanghai Argo Biopharmaceutical Co Ltd | COMPOSICIONES Y MÉTODOS PARA INHIBIR LA EXPRESIÓN DEL factor de coagulación XI (FXI) |
| WO2024249328A2 (en) | 2023-05-26 | 2024-12-05 | Adarx Pharmaceuticals, Inc. | Sod1-modulating compositions and methods of use thereof |
| WO2024245410A1 (zh) * | 2023-05-31 | 2024-12-05 | 上海拓界生物医药科技有限公司 | 一种靶向LPA的dsRNA及其应用 |
| WO2024255761A1 (zh) * | 2023-06-12 | 2024-12-19 | 大睿生物 | 包含糖的寡核苷酸递送配体 |
| CN119698475A (zh) | 2023-06-13 | 2025-03-25 | 昂拓生物医药有限公司 | 血管紧张素原的高效rna靶向(arnatar) |
| WO2024263694A1 (en) | 2023-06-20 | 2024-12-26 | Adarx Pharmaceuticals, Inc. | Lrrk2-modulating compositions and methods of use thereof |
| CN119219716A (zh) * | 2023-06-30 | 2024-12-31 | 上海维申医药有限公司 | 新型GalNAc的靶向递送片段及其制备和应用 |
| WO2025015335A1 (en) | 2023-07-13 | 2025-01-16 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| WO2025015338A1 (en) | 2023-07-13 | 2025-01-16 | Korro Bio, Inc. | Rna-editing oligonucleotides and uses thereof |
| GB202311324D0 (en) | 2023-07-24 | 2023-09-06 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
| WO2025021831A1 (en) | 2023-07-24 | 2025-01-30 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
| GB202311334D0 (en) | 2023-07-24 | 2023-09-06 | Astrazeneca Ab | Multivalent cargo-carrying complexes and uses thereof |
| WO2025034422A1 (en) | 2023-08-04 | 2025-02-13 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating ctnnb1-associated disorders |
| WO2025036916A1 (en) | 2023-08-16 | 2025-02-20 | Les Laboratoires Servier | Oligonucleotides for modulating kcnt1 expression |
| WO2025045194A1 (zh) * | 2023-08-31 | 2025-03-06 | 正大天晴药业集团股份有限公司 | 靶向凝血因子xi的双链核糖核酸 |
| TW202526017A (zh) * | 2023-09-14 | 2025-07-01 | 美商Ionis製藥公司 | 用於減少apociii表現的化合物及方法 |
| CN116925160B (zh) * | 2023-09-15 | 2023-12-08 | 天津全和诚科技有限责任公司 | 一种GalNAc含糖环中间体及其制备方法 |
| WO2025064821A2 (en) | 2023-09-21 | 2025-03-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for inhibiting lpa |
| WO2025064819A1 (en) * | 2023-09-21 | 2025-03-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for inhibiting lpa |
| GB202314724D0 (en) | 2023-09-26 | 2023-11-08 | Astrazeneca Ab | compounds and methods for reducing psd3 expression |
| WO2025072748A2 (en) * | 2023-09-29 | 2025-04-03 | Insitro, Inc. | Compositions and methods for treating nonalcoholic fatty liver disease |
| CN118680948B (zh) * | 2023-10-20 | 2025-08-22 | 思合基因(北京)生物科技有限公司 | 寡核苷酸及其在抗乙型肝炎病毒中的应用 |
| WO2025096809A1 (en) | 2023-10-31 | 2025-05-08 | Korro Bio, Inc. | Oligonucleotides comprising phosphoramidate internucleotide linkages |
| TW202521133A (zh) * | 2023-11-27 | 2025-06-01 | 大陸商上海舶望製藥有限公司 | 抑制甲狀腺素運載蛋白(ttr)表達的組合物和方法 |
| CN120098993A (zh) * | 2023-12-05 | 2025-06-06 | 广东东阳光药业股份有限公司 | 一种新型的双链siRNA、其缀合物及其用途 |
| CN120309684A (zh) * | 2024-01-15 | 2025-07-15 | 武汉人福创新药物研发中心有限公司 | 靶向化合物及其用途 |
| CN117568313B (zh) * | 2024-01-15 | 2024-04-26 | 上海贝斯昂科生物科技有限公司 | 基因编辑组合物及其用途 |
| WO2025155911A1 (en) | 2024-01-18 | 2025-07-24 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of hurler syndrome |
| WO2025165891A1 (en) | 2024-01-29 | 2025-08-07 | Arnatar Therapeutics, Inc | Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof |
| EP4665854A1 (en) | 2024-01-29 | 2025-12-24 | Arnatar Therapeutics, Inc | Translation enhancing nucleic acid compounds: aso coupled translation - upregulation 1 (act-up1) and uses thereof |
| WO2025196505A2 (en) | 2024-03-22 | 2025-09-25 | Takeda Pharmaceutical Company Limited | Compositions and methods for inhibiting cytochrome p450 family 7 subfamily a member 1 (cyp7a1) expression |
| GB202404661D0 (en) | 2024-04-02 | 2024-05-15 | Proqr Therapeutics Ii Bv | Antisense oligoncleotides for the treatment of liver disease |
| WO2025224230A1 (en) | 2024-04-25 | 2025-10-30 | Proqr Therapeutics Ii B.V. | Antisense oligonucleotides for the treatment of fatty liver disease |
| CN118146284B (zh) * | 2024-05-08 | 2024-07-26 | 北京悦康科创医药科技股份有限公司 | 一种GalNAc化合物、其与寡核苷酸缀合物及制备方法 |
| WO2025242702A1 (en) * | 2024-05-23 | 2025-11-27 | Glaxosmithkline Intellectual Property Development Limited | Enzymatic process for producing n-acetyl galactosamine clusters |
| WO2026006436A1 (en) | 2024-06-25 | 2026-01-02 | Korro Bio, Inc. | Methods and compositions for the adar-mediated editing of tar dna binding protein 43 kda (tdp43) |
Family Cites Families (384)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4415732A (en) | 1981-03-27 | 1983-11-15 | University Patents, Inc. | Phosphoramidite compounds and processes |
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4476301A (en) | 1982-04-29 | 1984-10-09 | Centre National De La Recherche Scientifique | Oligonucleotides, a process for preparing the same and their application as mediators of the action of interferon |
| DE3329892A1 (de) | 1983-08-18 | 1985-03-07 | Köster, Hubert, Prof. Dr., 2000 Hamburg | Verfahren zur herstellung von oligonucleotiden |
| US5118800A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | Oligonucleotides possessing a primary amino group in the terminal nucleotide |
| USRE34036E (en) | 1984-06-06 | 1992-08-18 | National Research Development Corporation | Data transmission using a transparent tone-in band system |
| US5550111A (en) | 1984-07-11 | 1996-08-27 | Temple University-Of The Commonwealth System Of Higher Education | Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof |
| FR2567892B1 (fr) | 1984-07-19 | 1989-02-17 | Centre Nat Rech Scient | Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons |
| US5367066A (en) | 1984-10-16 | 1994-11-22 | Chiron Corporation | Oligonucleotides with selectably cleavable and/or abasic sites |
| FR2575751B1 (fr) | 1985-01-08 | 1987-04-03 | Pasteur Institut | Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques |
| US4751219A (en) | 1985-02-05 | 1988-06-14 | Nederlandse Centrale Organisatie Voor Toegepast-Natuur-Wetenschappelijk Onderzoek | Synthetic glycolipides, a process for the preparation thereof and several uses for these synthetic glycolipides |
| US5405938A (en) | 1989-12-20 | 1995-04-11 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| EP0260032B1 (en) | 1986-09-08 | 1994-01-26 | Ajinomoto Co., Inc. | Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers |
| US5276019A (en) | 1987-03-25 | 1994-01-04 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| US5264423A (en) | 1987-03-25 | 1993-11-23 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors for replication of retroviruses and for the expression of oncogene products |
| GB8712540D0 (en) * | 1987-05-28 | 1987-07-01 | Ucb Sa | Expression of human proapolipoprotein a-i |
| CA1340032C (en) | 1987-06-24 | 1998-09-08 | Jim Haralambidis | Lucleoside derivatives |
| US4924624A (en) | 1987-10-22 | 1990-05-15 | Temple University-Of The Commonwealth System Of Higher Education | 2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof |
| US5188897A (en) | 1987-10-22 | 1993-02-23 | Temple University Of The Commonwealth System Of Higher Education | Encapsulated 2',5'-phosphorothioate oligoadenylates |
| WO1989005358A1 (en) | 1987-11-30 | 1989-06-15 | University Of Iowa Research Foundation | Dna and rna molecules stabilized by modifications of the 3'-terminal phosphodiester linkage and their use as nucleic acid probes and as therapeutic agents to block the expression of specifically targeted genes |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| JPH03503894A (ja) | 1988-03-25 | 1991-08-29 | ユニバーシィティ オブ バージニア アランミ パテンツ ファウンデイション | オリゴヌクレオチド n‐アルキルホスホラミデート |
| US5278302A (en) | 1988-05-26 | 1994-01-11 | University Patents, Inc. | Polynucleotide phosphorodithioates |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5175273A (en) | 1988-07-01 | 1992-12-29 | Genentech, Inc. | Nucleic acid intercalating agents |
| US5194599A (en) | 1988-09-23 | 1993-03-16 | Gilead Sciences, Inc. | Hydrogen phosphonodithioate compositions |
| US5256775A (en) | 1989-06-05 | 1993-10-26 | Gilead Sciences, Inc. | Exonuclease-resistant oligonucleotides |
| US5134066A (en) | 1989-08-29 | 1992-07-28 | Monsanto Company | Improved probes using nucleosides containing 3-dezauracil analogs |
| US5591722A (en) | 1989-09-15 | 1997-01-07 | Southern Research Institute | 2'-deoxy-4'-thioribonucleosides and their antiviral activity |
| US5721218A (en) | 1989-10-23 | 1998-02-24 | Gilead Sciences, Inc. | Oligonucleotides with inverted polarity |
| US5399676A (en) | 1989-10-23 | 1995-03-21 | Gilead Sciences | Oligonucleotides with inverted polarity |
| US5264564A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences | Oligonucleotide analogs with novel linkages |
| US5264562A (en) | 1989-10-24 | 1993-11-23 | Gilead Sciences, Inc. | Oligonucleotide analogs with novel linkages |
| DE69034150T2 (de) | 1989-10-24 | 2005-08-25 | Isis Pharmaceuticals, Inc., Carlsbad | 2'-Modifizierte Oligonukleotide |
| US5177198A (en) | 1989-11-30 | 1993-01-05 | University Of N.C. At Chapel Hill | Process for preparing oligoribonucleoside and oligodeoxyribonucleoside boranophosphates |
| US5130302A (en) | 1989-12-20 | 1992-07-14 | Boron Bilogicals, Inc. | Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same |
| US5457191A (en) | 1990-01-11 | 1995-10-10 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5859221A (en) | 1990-01-11 | 1999-01-12 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5623065A (en) | 1990-08-13 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Gapped 2' modified oligonucleotides |
| US5681941A (en) | 1990-01-11 | 1997-10-28 | Isis Pharmaceuticals, Inc. | Substituted purines and oligonucleotide cross-linking |
| US5587470A (en) | 1990-01-11 | 1996-12-24 | Isis Pharmaceuticals, Inc. | 3-deazapurines |
| US5670633A (en) | 1990-01-11 | 1997-09-23 | Isis Pharmaceuticals, Inc. | Sugar modified oligonucleotides that detect and modulate gene expression |
| US7101993B1 (en) | 1990-01-11 | 2006-09-05 | Isis Pharmaceuticals, Inc. | Oligonucleotides containing 2′-O-modified purines |
| US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
| US6005087A (en) | 1995-06-06 | 1999-12-21 | Isis Pharmaceuticals, Inc. | 2'-modified oligonucleotides |
| US5587361A (en) | 1991-10-15 | 1996-12-24 | Isis Pharmaceuticals, Inc. | Oligonucleotides having phosphorothioate linkages of high chiral purity |
| US5459255A (en) | 1990-01-11 | 1995-10-17 | Isis Pharmaceuticals, Inc. | N-2 substituted purines |
| US5149797A (en) | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| US5220007A (en) | 1990-02-15 | 1993-06-15 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of RNA and production of encoded polypeptides |
| US5321131A (en) | 1990-03-08 | 1994-06-14 | Hybridon, Inc. | Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling |
| US5470967A (en) | 1990-04-10 | 1995-11-28 | The Dupont Merck Pharmaceutical Company | Oligonucleotide analogs with sulfamate linkages |
| GB9009980D0 (en) | 1990-05-03 | 1990-06-27 | Amersham Int Plc | Phosphoramidite derivatives,their preparation and the use thereof in the incorporation of reporter groups on synthetic oligonucleotides |
| DK0455905T3 (da) | 1990-05-11 | 1998-12-07 | Microprobe Corp | Dipsticks til nukleinsyrehybridiseringsassays og fremgangsmåde til kovalent immobilisering af oligonukleotider |
| US5610289A (en) | 1990-07-27 | 1997-03-11 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogues |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| US5677437A (en) | 1990-07-27 | 1997-10-14 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5541307A (en) | 1990-07-27 | 1996-07-30 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs and solid phase synthesis thereof |
| US5608046A (en) | 1990-07-27 | 1997-03-04 | Isis Pharmaceuticals, Inc. | Conjugated 4'-desmethyl nucleoside analog compounds |
| US5623070A (en) | 1990-07-27 | 1997-04-22 | Isis Pharmaceuticals, Inc. | Heteroatomic oligonucleoside linkages |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5489677A (en) | 1990-07-27 | 1996-02-06 | Isis Pharmaceuticals, Inc. | Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms |
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| US5618704A (en) | 1990-07-27 | 1997-04-08 | Isis Pharmacueticals, Inc. | Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling |
| WO1992002258A1 (en) | 1990-07-27 | 1992-02-20 | Isis Pharmaceuticals, Inc. | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
| US5223618A (en) | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
| PT98562B (pt) | 1990-08-03 | 1999-01-29 | Sanofi Sa | Processo para a preparacao de composicoes que compreendem sequencias de nucleo-sidos com cerca de 6 a cerca de 200 bases resistentes a nucleases |
| US5177196A (en) | 1990-08-16 | 1993-01-05 | Microprobe Corporation | Oligo (α-arabinofuranosyl nucleotides) and α-arabinofuranosyl precursors thereof |
| US5214134A (en) | 1990-09-12 | 1993-05-25 | Sterling Winthrop Inc. | Process of linking nucleosides with a siloxane bridge |
| US5561225A (en) | 1990-09-19 | 1996-10-01 | Southern Research Institute | Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages |
| EP0549686A4 (en) | 1990-09-20 | 1995-01-18 | Gilead Sciences Inc | Modified internucleoside linkages |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5948903A (en) | 1991-01-11 | 1999-09-07 | Isis Pharmaceuticals, Inc. | Synthesis of 3-deazapurines |
| US5672697A (en) | 1991-02-08 | 1997-09-30 | Gilead Sciences, Inc. | Nucleoside 5'-methylene phosphonates |
| US7015315B1 (en) | 1991-12-24 | 2006-03-21 | Isis Pharmaceuticals, Inc. | Gapped oligonucleotides |
| US5571799A (en) | 1991-08-12 | 1996-11-05 | Basco, Ltd. | (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response |
| EP0538194B1 (de) | 1991-10-17 | 1997-06-04 | Novartis AG | Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte |
| US5594121A (en) | 1991-11-07 | 1997-01-14 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified purines |
| ATE226093T1 (de) | 1991-11-26 | 2002-11-15 | Isis Pharmaceuticals Inc | Gesteigerte bildung von triple- und doppelhelices aus oligomeren mit modifizierten pyrimidinen |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| US5792608A (en) | 1991-12-12 | 1998-08-11 | Gilead Sciences, Inc. | Nuclease stable and binding competent oligomers and methods for their use |
| US5359044A (en) | 1991-12-13 | 1994-10-25 | Isis Pharmaceuticals | Cyclobutyl oligonucleotide surrogates |
| US5700922A (en) | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| DK1695979T3 (da) * | 1991-12-24 | 2011-10-10 | Isis Pharmaceuticals Inc | Gappede modificerede oligonukleotider |
| FR2687679B1 (fr) | 1992-02-05 | 1994-10-28 | Centre Nat Rech Scient | Oligothionucleotides. |
| US5633360A (en) | 1992-04-14 | 1997-05-27 | Gilead Sciences, Inc. | Oligonucleotide analogs capable of passive cell membrane permeation |
| US5434257A (en) | 1992-06-01 | 1995-07-18 | Gilead Sciences, Inc. | Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages |
| EP0577558A2 (de) | 1992-07-01 | 1994-01-05 | Ciba-Geigy Ag | Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte |
| US5652355A (en) | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| JPH08502723A (ja) | 1992-07-27 | 1996-03-26 | ハイブライドン インコーポレイテッド | オリゴヌクレオチド・アルキルホスホノチオエート |
| RU95114435A (ru) | 1992-12-14 | 1997-05-20 | Ханивелл Инк. (Us) | Система с бесщеточным двигателем постоянного тока |
| DK0677056T3 (da) | 1993-01-25 | 1996-08-05 | Hybridon Inc | Oligonukleotid-alkylphosphonater og -alkylphosphonothioater |
| US5476925A (en) | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
| GB9304620D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Compounds |
| GB9304618D0 (en) | 1993-03-06 | 1993-04-21 | Ciba Geigy Ag | Chemical compounds |
| EP0691968B1 (en) | 1993-03-30 | 1997-07-16 | Sanofi | Acyclic nucleoside analogs and oligonucleotide sequences containing them |
| HU9501974D0 (en) | 1993-03-31 | 1995-09-28 | Sterling Winthrop Inc | Oligonucleotides with amide linkages replacing phosphodiester linkages |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US5801154A (en) | 1993-10-18 | 1998-09-01 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of multidrug resistance-associated protein |
| US5457187A (en) | 1993-12-08 | 1995-10-10 | Board Of Regents University Of Nebraska | Oligonucleotides containing 5-fluorouracil |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| WO1995015972A1 (en) | 1993-12-09 | 1995-06-15 | Thomas Jefferson University | Compounds and methods for site-directed mutations in eukaryotic cells |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5728518A (en) | 1994-01-12 | 1998-03-17 | The Immune Response Corporation | Antiviral poly-and oligonucleotides |
| US5596091A (en) | 1994-03-18 | 1997-01-21 | The Regents Of The University Of California | Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides |
| US5627053A (en) | 1994-03-29 | 1997-05-06 | Ribozyme Pharmaceuticals, Inc. | 2'deoxy-2'-alkylnucleotide containing nucleic acid |
| US5625050A (en) | 1994-03-31 | 1997-04-29 | Amgen Inc. | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics |
| US5646269A (en) | 1994-04-28 | 1997-07-08 | Gilead Sciences, Inc. | Method for oligonucleotide analog synthesis |
| US5525711A (en) | 1994-05-18 | 1996-06-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Pteridine nucleotide analogs as fluorescent DNA probes |
| US5597909A (en) | 1994-08-25 | 1997-01-28 | Chiron Corporation | Polynucleotide reagents containing modified deoxyribose moieties, and associated methods of synthesis and use |
| US5599706A (en) | 1994-09-23 | 1997-02-04 | Stinchcomb; Dan T. | Ribozymes targeted to apo(a) mRNA |
| US5681940A (en) * | 1994-11-02 | 1997-10-28 | Icn Pharmaceuticals | Sugar modified nucleosides and oligonucleotides |
| US6908903B1 (en) | 1994-12-07 | 2005-06-21 | Aletheon Pharmaceuticals, Inc. | Cluster clearing agents |
| US6172045B1 (en) | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
| US5652356A (en) | 1995-08-17 | 1997-07-29 | Hybridon, Inc. | Inverted chimeric and hybrid oligonucleotides |
| JP2000501414A (ja) | 1995-11-22 | 2000-02-08 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 生体分子の細胞取り込みを高めるリガンド |
| US20030119724A1 (en) | 1995-11-22 | 2003-06-26 | Ts`O Paul O.P. | Ligands to enhance cellular uptake of biomolecules |
| US5998203A (en) | 1996-04-16 | 1999-12-07 | Ribozyme Pharmaceuticals, Inc. | Enzymatic nucleic acids containing 5'-and/or 3'-cap structures |
| CN1231675A (zh) | 1996-09-26 | 1999-10-13 | 味之素株式会社 | 修饰的生理活性蛋白及含有该蛋白的药物组合物 |
| USRE44779E1 (en) | 1997-03-07 | 2014-02-25 | Santaris Pharma A/S | Bicyclonucleoside and oligonucleotide analogues |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6770748B2 (en) | 1997-03-07 | 2004-08-03 | Takeshi Imanishi | Bicyclonucleoside and oligonucleotide analogue |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| DE69829760T3 (de) | 1997-09-12 | 2016-04-14 | Exiqon A/S | Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga |
| US20040171564A1 (en) | 1997-11-20 | 2004-09-02 | Honkanen Richard E. | Antisense oligonucleotide modulation of human serine/threonine protein phosphatase gene expression |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US6300319B1 (en) | 1998-06-16 | 2001-10-09 | Isis Pharmaceuticals, Inc. | Targeted oligonucleotide conjugates |
| US6043352A (en) | 1998-08-07 | 2000-03-28 | Isis Pharmaceuticals, Inc. | 2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides |
| CN1263510C (zh) | 1998-08-19 | 2006-07-12 | 巴克斯特健康护理股份有限公司 | 多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用 |
| PL346645A1 (en) * | 1998-08-19 | 2002-02-25 | North American Vaccine | IMMUNOGENIC β-PROPIONAMIDO-LINKED POLYSACCHARIDE PROTEIN CONJUGATE USEFUL AS A VACCINE PRODUCED USING AN N-ACRYLOYLATED POLYSACCHARIDE |
| US6166239A (en) | 1998-09-04 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligonucleotide protecting groups |
| TR200102328T2 (tr) | 1999-02-12 | 2002-01-21 | Sankyo Company Limited | Yeni nükleosid ve oligonükleotid analogları |
| US20030170249A1 (en) | 1999-02-19 | 2003-09-11 | Hakomori Sen-Itiroh | Vaccines directed to cancer-associated carbohydrate antigens |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| US7098192B2 (en) | 1999-04-08 | 2006-08-29 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide modulation of STAT3 expression |
| US6159694A (en) | 1999-04-08 | 2000-12-12 | Isis Pharmaceuticals Inc. | Antisense modulation of stat3 expression |
| KR20070118315A (ko) | 1999-04-21 | 2007-12-14 | 와이어쓰 | 폴리뉴클레오티드 서열의 기능을 억제하기 위한 조성물 |
| KR100782896B1 (ko) | 1999-05-04 | 2007-12-06 | 엑시콘 에이/에스 | L-리보-lna 유사체 |
| US6525191B1 (en) | 1999-05-11 | 2003-02-25 | Kanda S. Ramasamy | Conformationally constrained L-nucleosides |
| US6383812B1 (en) | 1999-05-28 | 2002-05-07 | Academia Sinica | Anti liver disease drug R-YEEE and method of synthesizing branched galactose-terminal glycoproteins |
| US20080281041A1 (en) | 1999-06-07 | 2008-11-13 | Rozema David B | Reversibly Masked Polymers |
| US8541548B2 (en) | 1999-06-07 | 2013-09-24 | Arrowhead Madison Inc. | Compounds and methods for reversible modification of biologically active molecules |
| US6656730B1 (en) | 1999-06-15 | 2003-12-02 | Isis Pharmaceuticals, Inc. | Oligonucleotides conjugated to protein-binding drugs |
| CA2379152A1 (en) | 1999-07-16 | 2001-01-25 | Hyseq, Inc. | Novel angiopoietin materials and methods |
| JP4151751B2 (ja) | 1999-07-22 | 2008-09-17 | 第一三共株式会社 | 新規ビシクロヌクレオシド類縁体 |
| DE19935303A1 (de) | 1999-07-28 | 2001-02-08 | Aventis Pharma Gmbh | Oligonukleotide zur Inhibierung der Expression von humanem eg5 |
| US20020082227A1 (en) | 1999-09-30 | 2002-06-27 | Scott Henry | Use of oligonucleotides for inhibition of complement activation |
| US20050112118A1 (en) | 1999-12-02 | 2005-05-26 | Myriad Genetics, Incorporated | Compositions and methods for treating inflammatory disorders |
| HK1045541A1 (en) | 1999-12-09 | 2002-11-29 | Sankyo Company, Limited | Method of testing remedy or preventive for hyperlipemia |
| EP1244667B1 (en) | 1999-12-30 | 2006-04-05 | K.U. Leuven Research & Development | Cyclohexene nucleic acids |
| US20020055479A1 (en) | 2000-01-18 | 2002-05-09 | Cowsert Lex M. | Antisense modulation of PTP1B expression |
| US6602857B1 (en) | 2000-01-18 | 2003-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| US7179796B2 (en) | 2000-01-18 | 2007-02-20 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| US8202979B2 (en) | 2002-02-20 | 2012-06-19 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid |
| US7491805B2 (en) | 2001-05-18 | 2009-02-17 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
| AU2001241541A1 (en) | 2000-02-17 | 2001-08-27 | Millennium Predictive Medicine, Inc. | Novel genes, compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| US7053199B2 (en) | 2000-08-29 | 2006-05-30 | Takeshi Imanishi | Nucleoside analogs and oligonucleotide derivatives containing these analogs |
| US6426220B1 (en) | 2000-10-30 | 2002-07-30 | Isis Pharmaceuticals, Inc. | Antisense modulation of calreticulin expression |
| CA2431839A1 (en) | 2000-12-01 | 2002-06-06 | Paul O. P. Ts'o | Conjugates of glycosylated/galactosylated peptide |
| US20030077829A1 (en) | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
| IL159153A0 (en) | 2001-06-08 | 2004-06-01 | Sankyo Co | Methods for testing drugs for treating or preventing diseases such as hyperlipidemia |
| CA2452458A1 (en) | 2001-07-03 | 2003-01-16 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| US20030158403A1 (en) | 2001-07-03 | 2003-08-21 | Isis Pharmaceuticals, Inc. | Nuclease resistant chimeric oligonucleotides |
| US20030175906A1 (en) | 2001-07-03 | 2003-09-18 | Muthiah Manoharan | Nuclease resistant chimeric oligonucleotides |
| US7425545B2 (en) | 2001-07-25 | 2008-09-16 | Isis Pharmaceuticals, Inc. | Modulation of C-reactive protein expression |
| US6964950B2 (en) | 2001-07-25 | 2005-11-15 | Isis Pharmaceuticals, Inc. | Antisense modulation of C-reactive protein expression |
| US7259150B2 (en) | 2001-08-07 | 2007-08-21 | Isis Pharmaceuticals, Inc. | Modulation of apolipoprotein (a) expression |
| US7227014B2 (en) * | 2001-08-07 | 2007-06-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein (a) expression |
| WO2003014397A1 (en) | 2001-08-09 | 2003-02-20 | Biomedlab Corporation | Probe for detection of enteric virus detection kit and method for enteric virus with the same |
| EP1446412B1 (en) | 2001-09-04 | 2012-03-07 | Exiqon A/S | Novel lna compositions and uses thereof |
| US7439043B2 (en) | 2001-10-10 | 2008-10-21 | Neose Technologies, Inc. | Galactosyl nucleotide sugars |
| ES2429034T3 (es) | 2001-11-16 | 2013-11-12 | Genentech, Inc. | Uso de antagonistas de ANGPTL3 para el tratamiento de enfermedades hepáticas |
| US20100240730A1 (en) | 2002-02-20 | 2010-09-23 | Merck Sharp And Dohme Corp. | RNA Interference Mediated Inhibition of Gene Expression Using Chemically Modified Short Interfering Nucleic Acid (siNA) |
| WO2004011624A2 (en) | 2002-07-31 | 2004-02-05 | Nucleonics, Inc. | Double stranded rna structures and constructs, and methods for generating and using the same |
| WO2004014933A1 (en) | 2002-08-07 | 2004-02-19 | University Of Massachusetts | Compositions for rna interference and methods of use thereof |
| EP1543019A2 (en) | 2002-09-11 | 2005-06-22 | Santaris Pharma A/S | Modified pna molecules |
| CA2502649A1 (en) | 2002-10-18 | 2004-04-29 | Nucleonics Inc. | Double-stranded rna structures and constructs, and methods for generating and using the same |
| CA2504694C (en) | 2002-11-05 | 2013-10-01 | Isis Pharmaceuticals, Inc. | Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation |
| AU2003291755A1 (en) | 2002-11-05 | 2004-06-07 | Isis Pharmaceuticals, Inc. | Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use |
| CA2505801A1 (en) | 2002-11-13 | 2004-05-27 | Rosanne Crooke | Antisense modulation of apolipoprotein b expression |
| US20060009410A1 (en) | 2002-11-13 | 2006-01-12 | Crooke Rosanne M | Effects of apolipoprotein B inhibition on gene expression profiles in animals |
| US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
| JP2006507841A (ja) | 2002-11-14 | 2006-03-09 | ダーマコン, インコーポレイテッド | 機能的siRNAおよび超機能的siRNA |
| US7482117B2 (en) | 2002-12-20 | 2009-01-27 | Celera Corporation | Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof |
| US6673661B1 (en) | 2002-12-20 | 2004-01-06 | Taiwan Semiconductor Manufacturing Co., Ltd. | Self-aligned method for forming dual gate thin film transistor (TFT) device |
| US20070015927A1 (en) | 2003-01-09 | 2007-01-18 | Kim Byeang H | New phosphoramidite compounds |
| WO2004072046A2 (en) | 2003-02-12 | 2004-08-26 | Carex S.A. | Quinoline derivatives and their use for modulation of lxr activity |
| US7803781B2 (en) | 2003-02-28 | 2010-09-28 | Isis Pharmaceuticals, Inc. | Modulation of growth hormone receptor expression and insulin-like growth factor expression |
| ATE479752T1 (de) * | 2003-03-07 | 2010-09-15 | Alnylam Pharmaceuticals Inc | Therapeutische zusammensetzungen |
| AU2004227414A1 (en) * | 2003-04-03 | 2004-10-21 | Alnylam Pharmaceuticals | iRNA conjugates |
| US7598227B2 (en) | 2003-04-16 | 2009-10-06 | Isis Pharmaceuticals Inc. | Modulation of apolipoprotein C-III expression |
| WO2004094595A2 (en) | 2003-04-17 | 2004-11-04 | Alnylam Pharmaceuticals Inc. | MODIFIED iRNA AGENTS |
| US7851615B2 (en) | 2003-04-17 | 2010-12-14 | Alnylam Pharmaceuticals, Inc. | Lipophilic conjugated iRNA agents |
| US7723509B2 (en) | 2003-04-17 | 2010-05-25 | Alnylam Pharmaceuticals | IRNA agents with biocleavable tethers |
| US7750142B2 (en) | 2003-04-28 | 2010-07-06 | Isis Pharmaceuticals, Inc. | Modulation of glucagon receptor expression |
| US7399853B2 (en) | 2003-04-28 | 2008-07-15 | Isis Pharmaceuticals | Modulation of glucagon receptor expression |
| JPWO2004101619A1 (ja) | 2003-05-15 | 2006-10-26 | 塩野義製薬株式会社 | 機能的糖ペプチドの合理的設計および合成 |
| WO2004106356A1 (en) | 2003-05-27 | 2004-12-09 | Syddansk Universitet | Functionalized nucleotide derivatives |
| JP4731324B2 (ja) | 2003-08-28 | 2011-07-20 | 武 今西 | N−o結合性架橋構造型新規人工核酸 |
| SG146682A1 (en) | 2003-09-18 | 2008-10-30 | Isis Pharmaceuticals Inc | Modulation of eif4e expression |
| AU2004274021B2 (en) | 2003-09-18 | 2009-08-13 | Isis Pharmaceuticals, Inc. | 4'-thionucleosides and oligomeric compounds |
| US8258105B2 (en) * | 2003-10-07 | 2012-09-04 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides optimized for kidney targeting |
| US7959919B2 (en) | 2003-11-19 | 2011-06-14 | Novelmed Therapeutics, Inc. | Method of inhibiting factor B-mediated complement activation |
| WO2005065686A1 (en) | 2004-01-07 | 2005-07-21 | Adipogen Pharmaceuticals Pty Limited | Differentiation modulating agents and uses therefor |
| US20050164271A1 (en) | 2004-01-20 | 2005-07-28 | Sanjay Bhanot | Modulation of glucocorticoid receptor expression |
| CA2559962C (en) * | 2004-02-05 | 2011-03-15 | Japan Science And Technology Agency | Linker compound, ligand complex and process for producing them |
| US20050244869A1 (en) | 2004-04-05 | 2005-11-03 | Brown-Driver Vickie L | Modulation of transthyretin expression |
| JPWO2005097155A1 (ja) | 2004-04-08 | 2008-02-28 | タカラバイオ株式会社 | 神経突起伸長誘導剤 |
| AU2005248147A1 (en) | 2004-05-11 | 2005-12-08 | Alphagen Co., Ltd. | Polynucleotides for causing RNA interference and method for inhibiting gene expression using the same |
| EP1765416A4 (en) | 2004-06-03 | 2010-03-24 | Isis Pharmaceuticals Inc | DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION |
| LT1781698T (lt) | 2004-07-20 | 2016-09-26 | Genentech, Inc. | Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai |
| EP2361931B1 (en) | 2004-07-20 | 2017-12-06 | Genentech, Inc. | Inhibitors of angiopoietin-like 4 protein, combinations, and their use |
| DK2997980T3 (en) * | 2004-08-10 | 2018-03-26 | Kastle Therapeutics Llc | PROCEDURES FOR MODULATING LIPROPROTEIN AND CHOLESTEROL LEVELS |
| US7582744B2 (en) | 2004-08-10 | 2009-09-01 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides |
| US20090203132A1 (en) | 2004-09-09 | 2009-08-13 | Swayze Eric E | Pyrrolidinyl groups for attaching conjugates to oligomeric compounds |
| US20060089325A1 (en) | 2004-10-13 | 2006-04-27 | Sanjay Bhanot | Antisense modulation of PTP1B expression |
| WO2006047842A2 (en) | 2004-11-08 | 2006-05-11 | K.U. Leuven Research And Development | Modified nucleosides for rna interference |
| US20060148740A1 (en) | 2005-01-05 | 2006-07-06 | Prosensa B.V. | Mannose-6-phosphate receptor mediated gene transfer into muscle cells |
| US20080206869A1 (en) | 2005-01-24 | 2008-08-28 | Avaris Ab | Nucleic Acid Complex |
| EP1931778A2 (en) * | 2005-09-15 | 2008-06-18 | Santaris Pharma A/S | RNA ANTAGONIST COMPOUNDS FOR THE INHIBITION OF APO-Bl00 EXPRESSION |
| WO2007035759A1 (en) | 2005-09-19 | 2007-03-29 | Johnson & Johnson Pharmaceutical Research & Development L.L.C. | Modulation of glucocorticoid receptor expression |
| ES2369328T3 (es) | 2005-09-19 | 2011-11-29 | Isis Pharmaceuticals, Inc. | Modulación de la expresión del receptor de glucagón. |
| DK2161038T3 (da) * | 2006-01-26 | 2014-03-03 | Isis Pharmaceuticals Inc | Sammensætninger og deres anvendelser rettet mod Huntington |
| US7399845B2 (en) | 2006-01-27 | 2008-07-15 | Isis Pharmaceuticals, Inc. | 6-modified bicyclic nucleic acid analogs |
| US7569686B1 (en) | 2006-01-27 | 2009-08-04 | Isis Pharmaceuticals, Inc. | Compounds and methods for synthesis of bicyclic nucleic acid analogs |
| ES2366974T3 (es) * | 2006-05-05 | 2011-10-27 | Isis Pharmaceuticals, Inc. | Compuestos y procedimientos para modular la expresión de sglt2. |
| JP5731115B2 (ja) | 2006-05-05 | 2015-06-10 | アイシス ファーマシューティカルズ, インコーポレーテッド | 遺伝子発現を調節するための化合物および方法 |
| AU2007249349B2 (en) | 2006-05-11 | 2012-03-08 | Isis Pharmaceuticals, Inc. | 5'-Modified bicyclic nucleic acid analogs |
| US7666854B2 (en) | 2006-05-11 | 2010-02-23 | Isis Pharmaceuticals, Inc. | Bis-modified bicyclic nucleic acid analogs |
| CA2660052A1 (en) | 2006-08-04 | 2008-02-07 | Isis Pharmaceuticals, Inc. | Compositions and methods for the modulation of jnk proteins |
| US8658211B2 (en) | 2006-08-18 | 2014-02-25 | Arrowhead Madison Inc. | Polyconjugates for in vivo delivery of polynucleotides |
| KR101133799B1 (ko) | 2006-08-18 | 2012-04-24 | 에프. 호프만-라 로슈 아게 | 폴리뉴클레오타이드의 생체내 전달을 위한 다가접합체 |
| EP2081949B1 (en) | 2006-09-22 | 2014-12-10 | GE Healthcare Dharmacon, Inc. | Tripartite oligonucleotide complexes and methods for gene silencing by rna interference |
| ES2620472T5 (es) | 2006-10-18 | 2020-07-09 | Ionis Pharmaceuticals Inc | Compuestos antisentido |
| EP2453016A1 (en) | 2006-11-27 | 2012-05-16 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| US8093222B2 (en) | 2006-11-27 | 2012-01-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| HUE033960T2 (en) | 2006-12-08 | 2018-01-29 | Lexicon Pharmaceuticals Inc | Monoclonal Antibodies to ANGPTL3 |
| CN101616690B (zh) * | 2006-12-20 | 2015-11-25 | 爱克索马美国有限责任公司 | 用于治疗IL-1β相关疾病的方法 |
| US20100190837A1 (en) | 2007-02-15 | 2010-07-29 | Isis Pharmaceuticals, Inc. | 5'-Substituted-2-F' Modified Nucleosides and Oligomeric Compounds Prepared Therefrom |
| EP2604284A1 (en) | 2007-02-16 | 2013-06-19 | KTB Tumorforschungsgesellschaft mbH | Receptor And Antigen Targeted Prodrug |
| KR20090122465A (ko) | 2007-03-01 | 2009-11-30 | 어드벤스드 비젼 테라피스, 인코포레이티드 | 염증성 질환의 치료 |
| WO2009029293A2 (en) | 2007-03-02 | 2009-03-05 | Mdrna, Inc. | Nucleic acid compounds for inhibiting myc gene expression and uses thereof |
| WO2008131419A2 (en) | 2007-04-23 | 2008-10-30 | Alnylam Pharmaceuticals, Inc. | Glycoconjugates of rna interference agents |
| WO2008150729A2 (en) | 2007-05-30 | 2008-12-11 | Isis Pharmaceuticals, Inc. | N-substituted-aminomethylene bridged bicyclic nucleic acid analogs |
| DK2173760T4 (en) | 2007-06-08 | 2016-02-08 | Isis Pharmaceuticals Inc | Carbocyclic bicyclic nukleinsyreanaloge |
| WO2009003009A1 (en) | 2007-06-26 | 2008-12-31 | Enanta Pharmaceuticals, Inc. | Substituted pyrrolidine as anti-infectives |
| ATE538127T1 (de) | 2007-07-05 | 2012-01-15 | Isis Pharmaceuticals Inc | 6-disubstituierte bicyclische nukleinsäureanaloga |
| JP5572090B2 (ja) | 2007-08-15 | 2014-08-13 | アイシス ファーマシューティカルズ, インコーポレーテッド | テトラヒドロピラン核酸類似体 |
| CA2696699A1 (en) * | 2007-08-20 | 2009-02-26 | Protalix Ltd. | Saccharide-containing protein conjugates and uses thereof |
| JP5792955B2 (ja) * | 2007-10-01 | 2015-10-14 | アイシス ファーマシューティカルズ, インコーポレーテッド | 線維芽細胞増殖因子受容体4発現のアンチセンスモジュレーション |
| EP2227545A2 (en) | 2007-11-09 | 2010-09-15 | Isis Pharmaceuticals, Inc. | Modulation of factor 7 expression |
| WO2009067647A1 (en) | 2007-11-21 | 2009-05-28 | Isis Pharmaceuticals, Inc. | Carbocyclic alpha-l-bicyclic nucleic acid analogs |
| US20090247608A1 (en) * | 2007-12-04 | 2009-10-01 | Alnylam Pharmaceuticals, Inc. | Targeting Lipids |
| SG10201402793PA (en) | 2007-12-27 | 2014-10-30 | Stelic Inst Of Regenerative Medicine Stelic Inst & Co | Sugar chain-related gene and use thereof |
| EP2245039A4 (en) | 2008-01-31 | 2012-06-06 | Alnylam Pharmaceuticals Inc | OPTIMIZED METHODS FOR EXPORING DSRNA TO TARGET THE PCSK9 GEN |
| US8530640B2 (en) | 2008-02-07 | 2013-09-10 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexitol nucleic acid analogs |
| WO2009142822A2 (en) | 2008-03-26 | 2009-11-26 | Alnylam Pharmaceuticals, Inc. | 2-f modified rna interference agents |
| EP3604533A1 (en) | 2008-04-11 | 2020-02-05 | Arbutus Biopharma Corporation | Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components |
| WO2009143369A2 (en) | 2008-05-22 | 2009-11-26 | Isis Pharmaceuticals, Inc. | Method of preparing nucleosides and analogs thereof without using chromatography |
| WO2009148605A2 (en) | 2008-06-04 | 2009-12-10 | Isis Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia |
| US8216786B2 (en) | 2008-07-09 | 2012-07-10 | Celera Corporation | Genetic polymorphisms associated with cardiovascular diseases, methods of detection and uses thereof |
| US20110237646A1 (en) * | 2008-08-07 | 2011-09-29 | Isis Pharmaceuticals, Inc. | Modulation of transthyretin expression for the treatment of cns related disorders |
| JP2012513953A (ja) | 2008-09-23 | 2012-06-21 | アルニラム ファーマスーティカルズ インコーポレイテッド | 付加環化を用いたモノマーおよびオリゴヌクレオチドの化学修飾 |
| DK2361256T3 (da) | 2008-09-24 | 2013-07-01 | Isis Pharmaceuticals Inc | Cyclohexenyl-nukleinsyreanaloger |
| DK2356129T3 (da) | 2008-09-24 | 2013-05-13 | Isis Pharmaceuticals Inc | Substituerede alpha-L-bicykliske nukleosider |
| EP3335715A3 (en) | 2008-10-15 | 2018-08-08 | Ionis Pharmaceuticals, Inc. | Modulation of factor 11 expression |
| CA2739895C (en) * | 2008-10-20 | 2018-09-25 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of transthyretin |
| US8987435B2 (en) | 2008-10-24 | 2015-03-24 | Isis Pharmaceuticals, Inc. | Oligomeric compounds and methods |
| JP5763539B2 (ja) | 2008-10-24 | 2015-08-12 | アイシス ファーマシューティカルズ, インコーポレーテッド | 5’及び2’ビス置換ヌクレオシド及びそれから製造されるオリゴマー化合物 |
| CA2743139C (en) | 2008-11-10 | 2019-04-02 | Alnylam Pharmaceuticals, Inc. | Novel lipids and compositions for the delivery of therapeutics |
| EP2405921A4 (en) | 2009-01-26 | 2013-05-22 | Protiva Biotherapeutics Inc | COMPOSITIONS AND METHODS FOR INACTIVATION OF APOLIPOPROTEIN C-III EXPRESSION |
| EP3243504A1 (en) | 2009-01-29 | 2017-11-15 | Arbutus Biopharma Corporation | Improved lipid formulation |
| EP3424939A1 (en) | 2009-03-02 | 2019-01-09 | Alnylam Pharmaceuticals Inc. | Nucleic acid chemical modifications |
| FR2943060B1 (fr) | 2009-03-13 | 2013-01-04 | Commissariat Energie Atomique | Agents chelatants d'ions metalliques, leurs procedes de preparation et leurs applications |
| CN102458480A (zh) | 2009-04-15 | 2012-05-16 | Isis制药公司 | 因子xi对炎症反应的调节 |
| KR102229618B1 (ko) | 2009-05-05 | 2021-03-18 | 알닐람 파마슈티칼스 인코포레이티드 | 지질 조성물 |
| WO2010141511A2 (en) | 2009-06-01 | 2010-12-09 | Halo-Bio Rnai Therapeutics, Inc. | Polynucleotides for multivalent rna interference, compositions and methods of use thereof |
| NZ622843A (en) | 2009-06-10 | 2015-10-30 | Tekmira Pharmaceuticals Corp | Improved lipid formulation |
| NZ597504A (en) | 2009-06-15 | 2013-10-25 | Alnylam Pharmaceuticals Inc | Lipid formulated dsrna targeting the pcsk9 gene |
| BR112012000421A2 (pt) | 2009-07-06 | 2019-09-24 | Alnylam Pharmaceuticals Inc | composições e métodos para intensificar a produção de um produto biológico. |
| US8927513B2 (en) | 2009-07-07 | 2015-01-06 | Alnylam Pharmaceuticals, Inc. | 5′ phosphate mimics |
| WO2011005861A1 (en) | 2009-07-07 | 2011-01-13 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide end caps |
| US20120214862A1 (en) | 2009-07-16 | 2012-08-23 | Isis Pharmaceuticals, Inc. | Modulation of factor 7 expression |
| WO2011017521A2 (en) | 2009-08-06 | 2011-02-10 | Isis Pharmaceuticals, Inc. | Bicyclic cyclohexose nucleic acid analogs |
| US8901072B2 (en) * | 2009-08-12 | 2014-12-02 | The Medicines Company | Glycopeptide and lipoglycopeptide antibiotics with improved solubility |
| WO2011038288A1 (en) | 2009-09-25 | 2011-03-31 | Isis Pharmaceuticals, Inc. | Modulation of ttc39 expression to increase hdl |
| US8552163B2 (en) | 2009-09-25 | 2013-10-08 | Johns Hopkins University | Liver-targeting agents and their synthesis |
| EP2512491B1 (en) | 2009-10-16 | 2017-10-11 | Glaxo Group Limited | Hbv antisense inhibitors |
| TWI391144B (zh) | 2009-10-26 | 2013-04-01 | Iner Aec Executive Yuan | 一種定量肝殘餘功能的檢驗方法與其新穎肝受體造影檢驗藥劑 |
| TWI388338B (zh) | 2009-10-26 | 2013-03-11 | Iner Aec Executive Yuan | 對聚合醣鏈進行放射標誌以作為肝受體造影劑之方法 |
| JP5723378B2 (ja) * | 2009-11-03 | 2015-05-27 | アルナイラム ファーマシューティカルズ, インコーポレイテッドAlnylam Pharmaceuticals, Inc. | トランスサイレチン(ttr)を阻害する脂質製剤化組成物及び方法 |
| WO2011072290A2 (en) | 2009-12-11 | 2011-06-16 | The Regents Of The University Of Michigan | Targeted dendrimer-drug conjugates |
| AU2011203986C1 (en) | 2010-01-08 | 2015-03-05 | Ionis Pharmaceuticals, Inc. | Modulation of angiopoietin-like 3 expression |
| US9198972B2 (en) | 2010-01-28 | 2015-12-01 | Alnylam Pharmaceuticals, Inc. | Monomers and oligonucleotides comprising cycloaddition adduct(s) |
| NZ601737A (en) * | 2010-02-24 | 2013-06-28 | Arrowhead Res Corp | Compositions for targeted delivery of sirna |
| US9193752B2 (en) | 2010-03-17 | 2015-11-24 | Isis Pharmaceuticals, Inc. | 5′-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom |
| US20130109817A1 (en) | 2010-03-26 | 2013-05-02 | Mersana Therapeutics, Inc. | Modified Polymers for Delivery of Polynucleotides, Method of Manufacture, and Methods of Use Thereof |
| WO2011120053A1 (en) | 2010-03-26 | 2011-09-29 | Mersana Therapeutics, Inc. | Modified polymers for delivery of polynucleotides, method of manufacture, and methods of use thereof |
| ES2586127T3 (es) | 2010-03-30 | 2016-10-11 | Novartis Ag | Usos de inhibidores de DGAT1 |
| US9102938B2 (en) | 2010-04-01 | 2015-08-11 | Alnylam Pharmaceuticals, Inc. | 2′ and 5′ modified monomers and oligonucleotides |
| US9725479B2 (en) | 2010-04-22 | 2017-08-08 | Ionis Pharmaceuticals, Inc. | 5′-end derivatives |
| WO2011133876A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | Oligonucleotides comprising acyclic and abasic nucleosides and analogs |
| KR101869570B1 (ko) | 2010-04-28 | 2018-06-20 | 아이오니스 파마수티컬즈, 인코포레이티드 | 변형된 뉴클레오사이드 및 그로부터 제조된 올리고머 화합물 |
| EP3091027B1 (en) | 2010-04-28 | 2018-01-17 | Ionis Pharmaceuticals, Inc. | 5' modified nucleosides and oligomeric compounds prepared therefrom |
| RS56011B1 (sr) | 2010-04-29 | 2017-09-29 | Ionis Pharmaceuticals Inc | Modulacija ekspresije transtiretina |
| WO2011163121A1 (en) | 2010-06-21 | 2011-12-29 | Alnylam Pharmaceuticals, Inc. | Multifunctional copolymers for nucleic acid delivery |
| CA2812046A1 (en) * | 2010-09-15 | 2012-03-22 | Alnylam Pharmaceuticals, Inc. | Modified irna agents |
| WO2012067970A2 (en) | 2010-11-11 | 2012-05-24 | Ted M Dawson | Transcriptional repression leading to parkinson's disease |
| WO2012068187A1 (en) | 2010-11-19 | 2012-05-24 | Merck Sharp & Dohme Corp. | Poly(amide) polymers for the delivery of oligonucleotides |
| US8501930B2 (en) | 2010-12-17 | 2013-08-06 | Arrowhead Madison Inc. | Peptide-based in vivo siRNA delivery system |
| EP3192800A1 (en) | 2010-12-17 | 2017-07-19 | Arrowhead Pharmaceuticals, Inc. | Galactose cluster-pharmacokinetic modulator targeting moiety for sirna |
| EP2658981B1 (en) | 2010-12-29 | 2016-09-28 | F.Hoffmann-La Roche Ag | Small molecule conjugates for intracellular delivery of nucleic acids |
| EP3467109A1 (en) | 2011-02-08 | 2019-04-10 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| CN107012144A (zh) | 2011-04-01 | 2017-08-04 | Ionis制药公司 | 信号转导及转录激活蛋白3(stat3)表达的调节 |
| WO2012142458A1 (en) * | 2011-04-13 | 2012-10-18 | Isis Pharmaceuticals, Inc. | Antisense modulation of ptp1b expression |
| TW201303013A (zh) | 2011-04-21 | 2013-01-16 | Isis Pharmaceuticals Inc | B型肝炎病毒(hbv)表現之調節 |
| SG10201604074TA (en) | 2011-04-21 | 2016-07-28 | Isis Pharmaceuticals Inc | Modulation of hepatitis b virus (hbv) expression |
| SG194671A1 (en) | 2011-04-27 | 2013-12-30 | Isis Pharmaceuticals Inc | Modulation of apolipoprotein ciii (apociii) expression |
| WO2012174154A1 (en) | 2011-06-13 | 2012-12-20 | Isis Pharmaceuticals, Inc. | Modulation of inflammatory responses by factor vii |
| JP6043347B2 (ja) * | 2011-06-16 | 2016-12-14 | アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. | 線維芽細胞増殖因子受容体4の発現のアンチセンス調節 |
| CN107201364A (zh) | 2011-06-21 | 2017-09-26 | 阿尔尼拉姆医药品有限公司 | 用于抑制载脂蛋白c‑iii(apoc3)基因表达的组合物与方法 |
| MX345095B (es) | 2011-06-21 | 2017-01-17 | Alnylam Pharmaceuticals Inc | Composiciones de arni similares a angiopoyetina 3 (angptl3) y metodos para su uso. |
| WO2012177639A2 (en) | 2011-06-22 | 2012-12-27 | Alnylam Pharmaceuticals, Inc. | Bioprocessing and bioproduction using avian cell lines |
| US20130017250A1 (en) * | 2011-07-15 | 2013-01-17 | The Trustees Of Columbia University In The City Of New York | Methods For High Density Lipoprotein Cholesterol Regulation |
| HK1199736A1 (en) | 2011-08-26 | 2015-07-17 | 箭头研究公司 | Poly(vinyl ester) polymers for in vivo nucleic acid delivery |
| EP3453761A1 (en) | 2011-08-29 | 2019-03-13 | Ionis Pharmaceuticals, Inc. | Oligomer-conjugate complexes and their use |
| WO2013043817A1 (en) | 2011-09-20 | 2013-03-28 | Isis Phamaceuticals, Inc. | Antisense modulation of gcgr expression |
| HK1201555A1 (en) | 2011-10-25 | 2015-09-04 | Isis Pharmaceuticals, Inc. | Antisense modulation of gccr expression |
| US9399775B2 (en) | 2011-11-18 | 2016-07-26 | Alnylam Pharmaceuticals, Inc. | RNAi agents, compositions and methods of use thereof for treating transthyretin (TTR) associated diseases |
| AU2013216852A1 (en) | 2012-02-08 | 2014-08-21 | Isis Pharmaceuticals, Inc. | Methods and compositions for modulating Factor VII expression |
| WO2013142514A1 (en) | 2012-03-19 | 2013-09-26 | Isis Pharmaceuticals, Inc. | Methods and compositions for modulating alpha-1-antitrypsin expression |
| WO2013142571A2 (en) | 2012-03-20 | 2013-09-26 | Cornell University | Assays for the identification of compounds that modulate lipid homeostasis |
| US9133461B2 (en) | 2012-04-10 | 2015-09-15 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the ALAS1 gene |
| US9914922B2 (en) | 2012-04-20 | 2018-03-13 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleotides and uses thereof |
| WO2013159109A1 (en) | 2012-04-20 | 2013-10-24 | Isis Pharmaceuticals, Inc. | Modulation of hepatitis b virus (hbv) expression |
| TW201808342A (zh) | 2012-05-02 | 2018-03-16 | 喜納製藥公司 | 包含四galnac之新穎結合物及傳送寡核苷酸之方法 |
| US20150299696A1 (en) | 2012-05-02 | 2015-10-22 | Sirna Therapeutics, Inc. | SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS |
| US20160002624A1 (en) | 2012-05-17 | 2016-01-07 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotide compositions |
| US9574193B2 (en) | 2012-05-17 | 2017-02-21 | Ionis Pharmaceuticals, Inc. | Methods and compositions for modulating apolipoprotein (a) expression |
| SI2855500T1 (sl) | 2012-05-24 | 2020-10-30 | Ionis Pharmaceuticals, Inc. | Postopki in sestavki za moduliranje izražanja apolipoproteina(A) |
| WO2013192233A1 (en) | 2012-06-18 | 2013-12-27 | Isis Pharmaceuticals, Inc. | Compounds and method for improved cellular uptake of antisense compounds |
| EP4253395A3 (en) | 2012-08-06 | 2023-11-29 | Alnylam Pharmaceuticals, Inc. | Processes for the preparation of carbohydrate conjugated rna agents |
| US9695418B2 (en) | 2012-10-11 | 2017-07-04 | Ionis Pharmaceuticals, Inc. | Oligomeric compounds comprising bicyclic nucleosides and uses thereof |
| BR112015010116A2 (pt) | 2012-11-15 | 2017-08-22 | Roche Innovation Ct Copenhagen As | COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB |
| WO2014118272A1 (en) | 2013-01-30 | 2014-08-07 | Santaris Pharma A/S | Antimir-122 oligonucleotide carbohydrate conjugates |
| HK1215718A1 (zh) | 2013-01-30 | 2016-09-09 | F. Hoffmann-La Roche Ag | Lna寡核苷酸碳水化合物缀合物 |
| AU2014216137B2 (en) | 2013-02-14 | 2018-05-10 | Ionis Pharmaceuticals, Inc. | Modulation of Apolipoprotein C-III (ApoCIII) expression in lipoprotein lipase deficient (LPLD) populations |
| IL296543B2 (en) * | 2013-05-01 | 2025-02-01 | Ionis Pharmaceuticals Inc | Compositions and methods for modulating HBV and TTR expression |
| AU2013389474B2 (en) | 2013-05-16 | 2018-11-15 | Racthera Co., Ltd. | Transplantation adjuvant in cell therapy using neural progenitor cells |
| EP3656386A1 (en) | 2013-06-21 | 2020-05-27 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating apolipoprotein c-iii expression for improving a diabetic profile |
| CA2916252A1 (en) | 2013-06-21 | 2014-12-24 | Isis Pharmaceuticals, Inc. | Compositions and methods for modulation of target nucleic acids |
| JP6255092B2 (ja) | 2013-06-27 | 2017-12-27 | ロシュ イノベーション センター コペンハーゲン エーエス | Pcsk9を標的とするアンチセンスオリゴマーおよびコンジュゲート |
| KR102236784B1 (ko) | 2013-07-02 | 2021-04-05 | 아이오니스 파마수티컬즈, 인코포레이티드 | 성장 호르몬 수용체의 조절인자 |
| EP4039278A1 (en) | 2013-07-11 | 2022-08-10 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| CN105744959B (zh) | 2013-09-13 | 2020-12-01 | Ionis制药公司 | 补体因子b的调节剂 |
| WO2015042447A1 (en) | 2013-09-20 | 2015-03-26 | Isis Pharmaceuticals, Inc. | Targeted therapeutic nucleosides and their use |
| EP3068885A1 (en) | 2013-11-14 | 2016-09-21 | Roche Innovation Center Copenhagen A/S | Apob antisense conjugate compounds |
| AU2014360314B2 (en) | 2013-12-06 | 2018-04-26 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA |
| JP6482475B2 (ja) * | 2014-01-07 | 2019-03-13 | レナセラピューティクス株式会社 | アンチセンスオリゴヌクレオチド及び糖誘導体を含む二本鎖オリゴヌクレオチド |
| EP3811977B1 (en) | 2014-05-01 | 2025-12-03 | Ionis Pharmaceuticals, Inc. | Method for synthesis of reactive conjugate clusters |
| KR20200102553A (ko) | 2014-05-01 | 2020-08-31 | 아이오니스 파마수티컬즈, 인코포레이티드 | 성장 호르몬 수용체 발현을 조절하기 위한 조성물 및 방법 |
| BR122020024443B1 (pt) | 2014-05-01 | 2022-02-22 | Ionis Pharmaceuticals, Inc | Composto e composição farmacêutica para modulação da expressão de angptl3 |
| EP4534092A3 (en) | 2014-05-01 | 2025-07-02 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating pkk expression |
| UA121656C2 (uk) | 2014-05-01 | 2020-07-10 | Айоніс Фармасьютикалз, Інк. | Олігомерна сполука та спосіб лікування захворювання, пов'язаного з порушенням регуляції альтернативного шляху комплементу |
| US10570169B2 (en) | 2014-05-22 | 2020-02-25 | Ionis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| EP3151839A4 (en) | 2014-06-06 | 2018-02-28 | Ionis Pharmaceuticals, Inc. | Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds |
| LT4119569T (lt) * | 2015-11-06 | 2024-09-25 | Ionis Pharmaceuticals, Inc. | Konjuguoti priešprasmiai junginiai, skirti panaudoti terapijoje |
| JP7486920B2 (ja) * | 2015-11-06 | 2024-05-20 | アイオーニス ファーマシューティカルズ, インコーポレーテッド | アポリポタンパク質(a)発現の調節 |
-
2014
- 2014-05-01 IL IL296543A patent/IL296543B2/en unknown
- 2014-05-01 CN CN201480035624.5A patent/CN105392488B/zh active Active
- 2014-05-01 KR KR1020217003080A patent/KR20210014758A/ko not_active Ceased
- 2014-05-01 EP EP22181753.9A patent/EP4155403A1/en active Pending
- 2014-05-01 JP JP2016512054A patent/JP6995478B2/ja active Active
- 2014-05-01 KR KR1020247009422A patent/KR20240042220A/ko active Pending
- 2014-05-01 CN CN201910037434.1A patent/CN110079524B/zh active Active
- 2014-05-01 EP EP19160031.1A patent/EP3546579A1/en active Pending
- 2014-05-01 ES ES14791187T patent/ES2819213T3/es active Active
- 2014-05-01 JP JP2016512055A patent/JP6456362B2/ja not_active Expired - Fee Related
- 2014-05-01 HR HRP20190987TT patent/HRP20190987T1/hr unknown
- 2014-05-01 MX MX2015015264A patent/MX2015015264A/es active IP Right Grant
- 2014-05-01 EP EP14791344.6A patent/EP2992098B1/en active Active
- 2014-05-01 PT PT191649599T patent/PT3524680T/pt unknown
- 2014-05-01 RU RU2015151199A patent/RU2697152C2/ru active
- 2014-05-01 KR KR1020217039866A patent/KR102558571B1/ko active Active
- 2014-05-01 CA CA2921167A patent/CA2921167C/en active Active
- 2014-05-01 RU RU2015151204A patent/RU2686080C2/ru active
- 2014-05-01 AU AU2014259755A patent/AU2014259755B2/en active Active
- 2014-05-01 AU AU2014259756A patent/AU2014259756B2/en active Active
- 2014-05-01 SG SG11201508870VA patent/SG11201508870VA/en unknown
- 2014-05-01 EA EA201891479A patent/EA036584B1/ru unknown
- 2014-05-01 MY MYPI2018000863A patent/MY198359A/en unknown
- 2014-05-01 LT LTEP14791344.6T patent/LT2992098T/lt unknown
- 2014-05-01 UA UAA201708429A patent/UA120287C2/uk unknown
- 2014-05-01 HU HUE14791344A patent/HUE043697T2/hu unknown
- 2014-05-01 EP EP25155370.7A patent/EP4529927A3/en active Pending
- 2014-05-01 EP EP24189241.3A patent/EP4438129A3/en active Pending
- 2014-05-01 NZ NZ631537A patent/NZ631537A/en unknown
- 2014-05-01 RU RU2019124314A patent/RU2019124314A/ru unknown
- 2014-05-01 JP JP2016512051A patent/JP6769866B2/ja active Active
- 2014-05-01 ES ES14791557T patent/ES2778442T3/es active Active
- 2014-05-01 MX MX2015015263A patent/MX373306B/es active IP Right Grant
- 2014-05-01 MX MX2015015220A patent/MX384824B/es unknown
- 2014-05-01 BR BR112015027322A patent/BR112015027322A8/pt not_active Application Discontinuation
- 2014-05-01 CA CA2921518A patent/CA2921518A1/en not_active Abandoned
- 2014-05-01 CN CN201480035618.XA patent/CN105378085B/zh active Active
- 2014-05-01 RU RU2018112167A patent/RU2018112167A/ru not_active Application Discontinuation
- 2014-05-01 KR KR1020157033029A patent/KR102424855B1/ko active Active
- 2014-05-01 DK DK14791187.9T patent/DK2992009T3/da active
- 2014-05-01 RU RU2015151202A patent/RU2670614C9/ru active
- 2014-05-01 CN CN201480035635.3A patent/CN108064162B/zh active Active
- 2014-05-01 PL PL14791344T patent/PL2992098T3/pl unknown
- 2014-05-01 BR BR112015027319A patent/BR112015027319A8/pt active Search and Examination
- 2014-05-01 WO PCT/US2014/036462 patent/WO2014179626A2/en not_active Ceased
- 2014-05-01 KR KR1020217033430A patent/KR102482890B1/ko active Active
- 2014-05-01 MX MX2015015239A patent/MX373334B/es active IP Right Grant
- 2014-05-01 CA CA2921162A patent/CA2921162A1/en active Pending
- 2014-05-01 KR KR1020227045740A patent/KR20230006933A/ko not_active Ceased
- 2014-05-01 ES ES14791344T patent/ES2730015T3/es active Active
- 2014-05-01 KR KR1020187013079A patent/KR102138781B1/ko active Active
- 2014-05-01 CN CN201480035633.4A patent/CN105378082B/zh active Active
- 2014-05-01 DK DK14791344.6T patent/DK2992098T3/da active
- 2014-05-01 MX MX2016012654A patent/MX381034B/es unknown
- 2014-05-01 JP JP2016512053A patent/JP6387084B2/ja active Active
- 2014-05-01 BR BR122018009831-7A patent/BR122018009831B1/pt active IP Right Grant
- 2014-05-01 KR KR1020157033027A patent/KR101857707B1/ko active Active
- 2014-05-01 KR KR1020227025268A patent/KR102651423B1/ko active Active
- 2014-05-01 EP EP14791863.5A patent/EP2992097B1/en active Active
- 2014-05-01 EP EP19164959.9A patent/EP3524680B1/en active Active
- 2014-05-01 BR BR112015027321A patent/BR112015027321A8/pt not_active Application Discontinuation
- 2014-05-01 AU AU2014259757A patent/AU2014259757B2/en not_active Ceased
- 2014-05-01 EP EP20205948.1A patent/EP3828275A1/en active Pending
- 2014-05-01 AU AU2014259750A patent/AU2014259750B2/en active Active
- 2014-05-01 NZ NZ631512A patent/NZ631512A/en unknown
- 2014-05-01 JP JP2016512052A patent/JP6216444B2/ja active Active
- 2014-05-01 RU RU2015151200A patent/RU2699985C2/ru active
- 2014-05-01 NZ NZ631552A patent/NZ631552A/en not_active IP Right Cessation
- 2014-05-01 DK DK14791557.3T patent/DK2991656T3/da active
- 2014-05-01 US US14/888,318 patent/US9714421B2/en not_active Expired - Fee Related
- 2014-05-01 WO PCT/US2014/036466 patent/WO2014179629A2/en not_active Ceased
- 2014-05-01 PT PT14791344T patent/PT2992098T/pt unknown
- 2014-05-01 EP EP14791557.3A patent/EP2991656B1/en active Active
- 2014-05-01 RU RU2019110030A patent/RU2019110030A/ru unknown
- 2014-05-01 SM SM20190316T patent/SMT201900316T1/it unknown
- 2014-05-01 RS RS20190682A patent/RS58981B1/sr unknown
- 2014-05-01 SI SI201431207T patent/SI2992098T1/sl unknown
- 2014-05-01 BR BR112015027369-6A patent/BR112015027369B1/pt active IP Right Grant
- 2014-05-01 PE PE2016001724A patent/PE20161430A1/es unknown
- 2014-05-01 CN CN202010402246.7A patent/CN111593051A/zh active Pending
- 2014-05-01 KR KR1020207021245A patent/KR20200090966A/ko not_active Ceased
- 2014-05-01 MA MA60161A patent/MA60161B1/fr unknown
- 2014-05-01 NZ NZ753018A patent/NZ753018A/en unknown
- 2014-05-01 WO PCT/US2014/036452 patent/WO2014179620A1/en not_active Ceased
- 2014-05-01 NZ NZ740338A patent/NZ740338A/en unknown
- 2014-05-01 LT LTEP14791187.9T patent/LT2992009T/lt unknown
- 2014-05-01 IL IL284593A patent/IL284593B2/en unknown
- 2014-05-01 SG SG11201508800WA patent/SG11201508800WA/en unknown
- 2014-05-01 SG SG10201906382QA patent/SG10201906382QA/en unknown
- 2014-05-01 SG SG10201801813YA patent/SG10201801813YA/en unknown
- 2014-05-01 KR KR1020157033031A patent/KR20160002977A/ko not_active Ceased
- 2014-05-01 EP EP19206748.6A patent/EP3633039A1/en not_active Withdrawn
- 2014-05-01 CN CN202411684710.0A patent/CN119913147A/zh active Pending
- 2014-05-01 BR BR112015027377-7A patent/BR112015027377B1/pt active IP Right Grant
- 2014-05-01 MY MYPI2015703904A patent/MY178929A/en unknown
- 2014-05-01 KR KR1020217009333A patent/KR20210037752A/ko not_active Ceased
- 2014-05-01 SG SG10201801507RA patent/SG10201801507RA/en unknown
- 2014-05-01 KR KR1020197019617A patent/KR102212275B1/ko active Active
- 2014-05-01 CN CN202110394825.6A patent/CN113293163A/zh active Pending
- 2014-05-01 CN CN202111358415.2A patent/CN114058617A/zh active Pending
- 2014-05-01 US US14/267,842 patent/US9127276B2/en active Active
- 2014-05-01 EP EP14792010.2A patent/EP2991661B1/en active Active
- 2014-05-01 CN CN201480035625.XA patent/CN105377887B/zh active Active
- 2014-05-01 AU AU2014259759A patent/AU2014259759B2/en not_active Expired - Fee Related
- 2014-05-01 IL IL315582A patent/IL315582A/en unknown
- 2014-05-01 PL PL14791187T patent/PL2992009T3/pl unknown
- 2014-05-01 KR KR1020157033025A patent/KR102235678B1/ko not_active Expired - Fee Related
- 2014-05-01 EA EA201592093A patent/EA031393B1/ru unknown
- 2014-05-01 HR HRP20201378TT patent/HRP20201378T1/hr unknown
- 2014-05-01 PT PT147911879T patent/PT2992009T/pt unknown
- 2014-05-01 DK DK19164959.9T patent/DK3524680T3/da active
- 2014-05-01 WO PCT/US2014/036463 patent/WO2014179627A2/en not_active Ceased
- 2014-05-01 KR KR1020157033028A patent/KR102315836B1/ko active Active
- 2014-05-01 CR CR20190269A patent/CR20190269A/es unknown
- 2014-05-01 CA CA2921514A patent/CA2921514C/en active Active
- 2014-05-01 ME MEP-2019-157A patent/ME03390B/me unknown
- 2014-05-01 EP EP14791187.9A patent/EP2992009B1/en active Active
- 2014-05-01 CA CA2921509A patent/CA2921509C/en active Active
- 2014-05-01 EP EP19217148.6A patent/EP3690049A1/en active Pending
- 2014-05-01 MX MX2015015234A patent/MX2015015234A/es active IP Right Grant
- 2014-05-01 UA UAA201511840A patent/UA121017C2/uk unknown
- 2014-05-01 WO PCT/US2014/036460 patent/WO2014179625A1/en not_active Ceased
- 2014-05-01 ES ES19164959T patent/ES2885174T3/es active Active
- 2014-05-01 CN CN202011081520.1A patent/CN112921036B/zh active Active
- 2014-05-01 RS RS20201052A patent/RS60796B1/sr unknown
- 2014-05-01 PE PE2015002330A patent/PE20152002A1/es unknown
- 2014-05-01 RU RU2015151203A patent/RU2650510C2/ru active
- 2014-05-01 HU HUE14791187A patent/HUE050394T2/hu unknown
- 2014-05-01 CN CN201910036892.3A patent/CN110042098B/zh active Active
- 2014-05-01 KR KR1020237024621A patent/KR102712053B1/ko active Active
- 2014-05-01 SI SI201431660T patent/SI2992009T1/sl unknown
- 2014-05-01 CN CN201910037432.2A patent/CN110066795A/zh active Pending
- 2014-05-01 KR KR1020247032116A patent/KR20240147701A/ko active Pending
- 2014-12-30 US US14/586,751 patent/US9181549B2/en active Active
- 2014-12-30 US US14/586,826 patent/US9163239B2/en active Active
- 2014-12-31 US US14/588,061 patent/US9181550B2/en active Active
-
2015
- 2015-02-27 US US14/633,491 patent/US9145558B2/en active Active
- 2015-06-19 US US14/744,539 patent/US20160017323A1/en not_active Abandoned
- 2015-08-10 US US14/822,493 patent/US9932580B2/en active Active
- 2015-08-28 US US14/839,521 patent/US9932581B2/en active Active
- 2015-08-28 US US14/839,580 patent/US9957504B2/en active Active
- 2015-09-29 ZA ZA2015/07218A patent/ZA201507218B/en unknown
- 2015-09-29 ZA ZA2015/07216A patent/ZA201507216B/en unknown
- 2015-10-15 IL IL242132A patent/IL242132B/en active IP Right Grant
- 2015-10-15 IL IL242124A patent/IL242124B/en active IP Right Grant
- 2015-10-15 IL IL242125A patent/IL242125B/en active IP Right Grant
- 2015-10-15 IL IL242126A patent/IL242126B/en active IP Right Grant
- 2015-10-28 DO DO2015000268A patent/DOP2015000268A/es unknown
- 2015-10-29 PH PH12015502493A patent/PH12015502493B1/en unknown
- 2015-10-30 MX MX2021008899A patent/MX2021008899A/es unknown
- 2015-10-30 MX MX2021008901A patent/MX2021008901A/es unknown
- 2015-10-30 MX MX2019010443A patent/MX2019010443A/es unknown
- 2015-10-30 MX MX2020002184A patent/MX2020002184A/es unknown
- 2015-10-30 MX MX2019010441A patent/MX2019010441A/es unknown
- 2015-10-30 CL CL2015003217A patent/CL2015003217A1/es unknown
- 2015-10-30 MX MX2020004209A patent/MX2020004209A/es unknown
- 2015-11-12 CR CR20150612A patent/CR20150612A/es unknown
-
2016
- 2016-09-07 CL CL2016002262A patent/CL2016002262A1/es unknown
- 2016-10-24 DO DO2016000287A patent/DOP2016000287A/es unknown
-
2017
- 2017-01-19 AU AU2017200365A patent/AU2017200365C1/en active Active
- 2017-02-13 AU AU2017200950A patent/AU2017200950B2/en active Active
- 2017-05-23 AU AU2017203436A patent/AU2017203436B2/en active Active
- 2017-06-09 US US15/618,365 patent/US20180002693A1/en not_active Abandoned
- 2017-08-25 US US15/687,306 patent/US10683499B2/en active Active
- 2017-09-22 JP JP2017182019A patent/JP6592486B2/ja active Active
-
2018
- 2018-02-07 US US15/891,118 patent/US10927372B2/en active Active
- 2018-02-07 US US15/891,156 patent/US10883104B2/en active Active
- 2018-02-14 US US15/896,379 patent/US20190055554A1/en not_active Abandoned
- 2018-08-07 JP JP2018148112A patent/JP6652602B2/ja active Active
- 2018-09-12 PH PH12018501963A patent/PH12018501963A1/en unknown
- 2018-09-20 IL IL261901A patent/IL261901B/en active IP Right Grant
- 2018-11-22 AU AU2018267625A patent/AU2018267625B2/en active Active
- 2018-12-18 JP JP2018236205A patent/JP6639629B2/ja not_active Expired - Fee Related
- 2018-12-19 IL IL263843A patent/IL263843B/en active IP Right Grant
- 2018-12-26 US US16/232,733 patent/US10844379B2/en active Active
-
2019
- 2019-01-14 IL IL264241A patent/IL264241B/en active IP Right Grant
- 2019-01-31 IL IL264580A patent/IL264580B/en active IP Right Grant
- 2019-02-07 AU AU2019200820A patent/AU2019200820B2/en active Active
- 2019-04-15 AU AU2019202598A patent/AU2019202598A1/en not_active Abandoned
- 2019-05-25 AU AU2019203674A patent/AU2019203674B2/en active Active
- 2019-05-29 PH PH12019501191A patent/PH12019501191A1/en unknown
- 2019-06-26 CY CY20191100660T patent/CY1121879T1/el unknown
- 2019-07-03 AU AU2019204784A patent/AU2019204784C1/en active Active
- 2019-09-19 JP JP2019170394A patent/JP7429103B2/ja active Active
- 2019-11-06 IL IL270464A patent/IL270464B/en unknown
- 2019-11-22 JP JP2019211075A patent/JP2020039355A/ja active Pending
- 2019-11-22 JP JP2019211074A patent/JP6866459B2/ja active Active
- 2019-12-20 JP JP2019229981A patent/JP2020058370A/ja not_active Ceased
-
2020
- 2020-01-23 JP JP2020008836A patent/JP2020074787A/ja active Pending
- 2020-02-12 IL IL272617A patent/IL272617A/en unknown
- 2020-02-13 US US16/790,557 patent/US20220275365A9/en not_active Abandoned
- 2020-03-02 US US16/806,941 patent/US20200224198A1/en not_active Abandoned
- 2020-03-09 IL IL273184A patent/IL273184B/en unknown
- 2020-03-10 IL IL273205A patent/IL273205A/en unknown
- 2020-03-15 IL IL273312A patent/IL273312A/en unknown
- 2020-04-20 IL IL274064A patent/IL274064B/en active IP Right Grant
- 2020-06-24 US US16/910,727 patent/US20210130823A1/en not_active Abandoned
- 2020-07-22 AU AU2020207820A patent/AU2020207820A1/en not_active Withdrawn
- 2020-08-11 AU AU2020217347A patent/AU2020217347A1/en not_active Abandoned
- 2020-09-14 AU AU2020233603A patent/AU2020233603A1/en not_active Abandoned
- 2020-09-22 CY CY20201100892T patent/CY1123369T1/el unknown
- 2020-09-23 JP JP2020158332A patent/JP7177127B2/ja active Active
- 2020-10-01 US US17/060,440 patent/US11851655B2/en active Active
- 2020-10-14 US US17/070,287 patent/US11299736B1/en active Active
- 2020-12-07 US US17/114,177 patent/US20210395734A1/en not_active Abandoned
-
2021
- 2021-02-17 JP JP2021023118A patent/JP2021074021A/ja not_active Withdrawn
- 2021-04-07 JP JP2021065088A patent/JP7339294B2/ja active Active
- 2021-05-17 DO DO2021000095A patent/DOP2021000095A/es unknown
- 2021-06-02 IL IL283660A patent/IL283660A/en unknown
- 2021-06-14 IL IL284000A patent/IL284000A/en unknown
- 2021-06-23 AU AU2021204244A patent/AU2021204244B2/en active Active
- 2021-11-05 JP JP2021181533A patent/JP2022017514A/ja active Pending
-
2022
- 2022-04-27 AU AU2022202770A patent/AU2022202770B2/en active Active
- 2022-10-21 US US17/970,887 patent/US12516319B2/en active Active
- 2022-11-10 JP JP2022180094A patent/JP2023012548A/ja active Pending
-
2023
- 2023-06-07 JP JP2023093703A patent/JP7633311B2/ja active Active
- 2023-07-11 US US18/350,195 patent/US20240247260A1/en not_active Abandoned
- 2023-10-23 JP JP2023181938A patent/JP2024010070A/ja active Pending
- 2023-11-03 US US18/501,779 patent/US12291709B2/en active Active
-
2024
- 2024-01-17 AU AU2024200296A patent/AU2024200296A1/en active Pending
- 2024-01-19 US US18/417,807 patent/US12509684B2/en active Active
- 2024-06-05 JP JP2024091116A patent/JP2024116224A/ja active Pending
- 2024-11-22 AU AU2024266799A patent/AU2024266799A1/en active Pending
- 2024-12-16 US US18/983,163 patent/US20250346899A1/en active Pending
-
2025
- 2025-02-06 JP JP2025018106A patent/JP7799103B2/ja active Active
- 2025-07-14 JP JP2025118631A patent/JP2025174962A/ja active Pending
- 2025-08-13 NO NO2025037C patent/NO2025037I1/no unknown
- 2025-08-18 FI FIC20250028C patent/FIC20250028I1/fi unknown
- 2025-08-30 FR FR25C1033C patent/FR25C1033I1/fr active Active
- 2025-09-03 NL NL301341C patent/NL301341I2/nl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NL301341I2 (nl) | eplontersen, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301245I2 (nl) | Ritlecitinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301161I2 (nl) | zanubrutinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301155I2 (nl) | abrocitinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301327I2 (nl) | Belzutifan, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, in het bijzonder belzutifan | |
| NL301238I2 (nl) | Deucravacitinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301149I2 (nl) | setmelanotide, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301329I2 (nl) | Lazertinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301006I2 (nl) | Lorlatinib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301279I2 (nl) | Adagrasib, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301292I2 (nl) | Iptacopan of een farmaceutisch aanvaardbaar zout daarvan | |
| NL301342I2 (nl) | Elafibranor, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301253I2 (nl) | mavacamten of een farmaceutisch aanvaardbaar zout daarvan | |
| NL301326I2 (nl) | imetelstat, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301224I2 (nl) | Combinatie van foslevodopa en foscarbidopa, elk desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL301276I2 (nl) | omaveloxolon of een farmaceutisch aanvaardbaar zout daarvan | |
| NL301131I2 (nl) | pemigatinib of een farmaceutisch aanvaardbaar zout daarvan | |
| NO2022010I1 (no) | ripretinib, or a pharmaceutically acceptable salt thereof | |
| NL301201I2 (nl) | Asciminib of een farmaceutisch aanvaardbaar zout daarvan, zoals asciminibhydrochloride | |
| NO2021041I1 (no) | remimazolam or a pharmaceutically acceptable salt thereof | |
| NL301047I2 (nl) | fosnetupitant, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout, in het bijzonder fosnetupitantchloridehydrochloride | |
| NL301260I2 (nl) | Gefapixant, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout. | |
| NL300980I2 (nl) | Doravirine, desgewenst in de vorm van een farmaceutisch aanvaardbaar zout | |
| NL300947I2 (nl) | Bictegravir of een farmaceutisch aanvaardbaar zout daarvan, in het bijzonder bictegravirnatrium | |
| NL301030I2 (nl) | Sarolaner, desgewenst in de vorm van een zout; moxidectine; en pyrantel embonaat |