MA52546A - Compositions ciblées - Google Patents
Compositions cibléesInfo
- Publication number
- MA52546A MA52546A MA052546A MA52546A MA52546A MA 52546 A MA52546 A MA 52546A MA 052546 A MA052546 A MA 052546A MA 52546 A MA52546 A MA 52546A MA 52546 A MA52546 A MA 52546A
- Authority
- MA
- Morocco
- Prior art keywords
- targeted compositions
- targeted
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762484247P | 2017-04-11 | 2017-04-11 | |
US201762525071P | 2017-06-26 | 2017-06-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA52546A true MA52546A (fr) | 2020-02-19 |
Family
ID=62063656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA052546A MA52546A (fr) | 2017-04-11 | 2018-04-10 | Compositions ciblées |
Country Status (15)
Country | Link |
---|---|
US (2) | US11427823B2 (fr) |
EP (2) | EP3950004A1 (fr) |
JP (2) | JP2020516296A (fr) |
KR (2) | KR20240049852A (fr) |
CN (2) | CN110741087B (fr) |
AU (1) | AU2018250553A1 (fr) |
BR (1) | BR112019021359A2 (fr) |
CA (1) | CA3059426A1 (fr) |
MA (1) | MA52546A (fr) |
MX (1) | MX2019012280A (fr) |
NZ (1) | NZ757927A (fr) |
PH (1) | PH12019502333A1 (fr) |
SG (1) | SG11201909433XA (fr) |
TW (2) | TW202413641A (fr) |
WO (1) | WO2018191278A2 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA45478A (fr) * | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
WO2018191278A2 (fr) | 2017-04-11 | 2018-10-18 | Arbutus Biopharma Corporation | Compositions ciblées |
CA3083968C (fr) | 2017-12-01 | 2024-04-23 | Suzhou Ribo Life Science Co., Ltd. | Oligonucleotide double brin, composition et conjugue comprenant un oligonucleotide double brin, procede de preparation et utilisation associes |
CN110997917B (zh) | 2017-12-01 | 2024-04-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
US11414665B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
CN118236391A (zh) | 2017-12-01 | 2024-06-25 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
CN110959011B (zh) | 2017-12-29 | 2023-03-28 | 苏州瑞博生物技术股份有限公司 | 缀合物及其制备方法和用途 |
EP3842534A4 (fr) | 2018-08-21 | 2022-07-06 | Suzhou Ribo Life Science Co., Ltd. | Acide nucléique, composition et conjugué contenant un acide nucléique et leur procédé d'utilisation |
JP7376952B2 (ja) | 2018-09-30 | 2023-11-09 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | siRNA複合体及びその調製方法と使用 |
US20220062323A1 (en) * | 2018-11-02 | 2022-03-03 | Arbutus Biopharma Corporation | Bivalent targeted conjugates |
KR20210120988A (ko) * | 2018-11-02 | 2021-10-07 | 제네반트 사이언시즈 게엠베하 | 치료 방법 |
US20220168430A1 (en) * | 2019-03-20 | 2022-06-02 | Arbutus Biopharma Corporation | Therapeutic methods for treating hepatitis b |
WO2020233655A1 (fr) * | 2019-05-22 | 2020-11-26 | 苏州瑞博生物技术股份有限公司 | Acide nucléique, composition pharmaceutique, conjugué, procédé de préparation et utilisation |
EP3986456A1 (fr) | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Combinaison de vaccins contre le virus de l'hépatite b (hbv) et d'arni ciblant le hbv |
KR20220112788A (ko) * | 2019-12-06 | 2022-08-11 | 제네반트 사이언시즈 게엠베하 | 간 섬유증 치료용 콘쥬게이트 및 이의 치료 방법 |
MX2022007738A (es) * | 2019-12-20 | 2022-07-19 | Arbutus Biopharma Corp | Procesos e intermedios sinteticos. |
IL302530A (en) * | 2020-11-06 | 2023-07-01 | Arbutus Biopharma Corp | Targeted conjugates involving modified siRNA |
TW202333751A (zh) * | 2021-12-16 | 2023-09-01 | 大陸商上海拓界生物醫藥科技有限公司 | 一種dsrna、其製備方法及應用 |
CN117561268A (zh) * | 2022-01-20 | 2024-02-13 | 上海金中锘美生物医药科技有限公司 | 靶向配体及其用途 |
CN117756866A (zh) * | 2022-01-30 | 2024-03-26 | 大睿生物医药科技(上海)有限公司 | 含有n-乙酰半乳糖胺的靶向配体 |
US11879125B2 (en) | 2022-03-16 | 2024-01-23 | Empirico Inc. | GalNAc compositions for improving siRNA bioavailability |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US6303120B1 (en) | 1994-03-15 | 2001-10-16 | Memorial Sloan-Kettering Institute For Cancer Research | Synthesis of glycoconjugates of the lewis y epitope and uses thereof |
US5708163A (en) | 1994-03-15 | 1998-01-13 | Sloan-Kettering Institute Of Cancer Research | Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof |
US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
WO2000003683A2 (fr) | 1998-07-20 | 2000-01-27 | Inex Pharmaceuticals Corporation | Complexes d'acides nucleiques encapsules dans des liposomes |
US7833992B2 (en) | 2001-05-18 | 2010-11-16 | Merck Sharpe & Dohme | Conjugates and compositions for cellular delivery |
WO2003070918A2 (fr) | 2002-02-20 | 2003-08-28 | Ribozyme Pharmaceuticals, Incorporated | Inhibition mediee par interference arn d'une expression genique faisant appel a des acides nucleiques interferants courts chimiquement modifies (sina) |
US8258288B2 (en) | 2002-02-20 | 2012-09-04 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of respiratory syncytial virus (RSV) expression using short interfering nucleic acid (siNA) |
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
AU2003245160B2 (en) | 2002-06-28 | 2009-09-24 | Arbutus Biopharma Corporation | Method and apparatus for producing liposomes |
US20080207539A1 (en) * | 2003-09-01 | 2008-08-28 | Patrick Arbuthnot | Self-Processing Rna Expression Cassette |
WO2005026165A1 (fr) | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Agents antibacteriens a base de quinolone |
AU2006274413B2 (en) | 2005-07-27 | 2013-01-10 | Arbutus Biopharma Corporation | Systems and methods for manufacturing liposomes |
AU2008256644B2 (en) | 2007-05-24 | 2014-07-03 | The United States Government As Represented By The Department Of Veterans Affairs | Intranuclear protein transduction through a nucleoside salvage pathway |
EP2231194B1 (fr) | 2007-12-04 | 2017-02-22 | Alnylam Pharmaceuticals Inc. | Conjugués du folate |
US20090247608A1 (en) | 2007-12-04 | 2009-10-01 | Alnylam Pharmaceuticals, Inc. | Targeting Lipids |
US8541388B2 (en) | 2008-05-22 | 2013-09-24 | Isis Pharmaceuticals, Inc. | Methods for modulating expression of RBP4 |
CN101603042B (zh) * | 2008-06-13 | 2013-05-01 | 厦门大学 | 可用于乙型肝炎病毒感染治疗的rna干扰靶点 |
KR101647334B1 (ko) | 2008-07-10 | 2016-08-10 | 세리나 쎄라퓨틱스, 인코포레이티드 | 불활성 말단기를 가진 폴리옥사졸린, 보호된 개시기로부터 제조된 폴리옥사졸린 및 그와 관련된 화합물 |
EP2496238A4 (fr) | 2009-11-03 | 2013-10-02 | Alnylam Pharmaceuticals Inc | Compositions de lipides formulés et procédés pour l'inhibition de l'expression de transthyrétine (ttr) |
EA024534B1 (ru) | 2010-02-24 | 2016-09-30 | Эрроухэд Рисерч Корпорейшн | КОНЪЮГИРОВАННАЯ СИСТЕМА ДОСТАВКИ И КОМПОЗИЦИЯ ДЛЯ НАПРАВЛЕННОЙ ДОСТАВКИ МАЛЫХ ИНТЕРФЕРИРУЮЩИХ РНК (миРНК) И СПОСОБ ПОЛУЧЕНИЯ КОМПОЗИЦИИ |
AU2011343664B2 (en) | 2010-12-17 | 2015-10-08 | Arrowhead Pharmaceuticals, Inc. | Galactose cluster-pharmacokinetic modulator targeting moiety for siRNA |
DK2751270T3 (en) | 2011-08-29 | 2018-10-29 | Ionis Pharmaceuticals Inc | OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE |
EP2780454A2 (fr) | 2011-11-18 | 2014-09-24 | Alnylam Pharmaceuticals, Inc. | Agents arni modifiés |
BR112014011896B1 (pt) * | 2011-11-18 | 2021-01-19 | Alnylam Pharmaceuticals, Inc. | Agentes de rnai, composições, método de inibição de expressão de uma transtirretina(ttr), uso destes agentes, e kits |
BR112015010116A2 (pt) | 2012-11-15 | 2017-08-22 | Roche Innovation Ct Copenhagen As | COMPOSTOS CONJUGADOS ANTI-SENTIDO ANTI-ApoB |
MX2015015239A (es) | 2013-05-01 | 2016-10-03 | Ionis Pharmaceuticals Inc | Composiciones y metodos. |
WO2014205451A2 (fr) | 2013-06-21 | 2014-12-24 | Isis Pharmaceuticals, Inc. | Compositions et méthodes pour moduler des acides nucléiques cibles |
RS59986B1 (sr) | 2013-06-27 | 2020-03-31 | Roche Innovation Ct Copenhagen As | Antisens oligomeri i konjugati koji ciljno deluju na pcsk9 |
WO2015042564A1 (fr) | 2013-09-23 | 2015-03-26 | Alnylam Pharmaceuticals, Inc. | Méthodes pour le traitement ou la prévention de maladies associées à la transthyrétine (ttr) |
BR112016022855B1 (pt) | 2014-05-01 | 2022-08-02 | Ionis Pharmaceuticals, Inc | Compostos e composições para modular a expressão de pkk e seus usos |
JOP20200115A1 (ar) | 2014-10-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات)) |
RU2017114156A (ru) | 2014-10-10 | 2018-11-15 | Ф. Хоффманн-Ля Рош Аг | N-ацетилгалактозаминовые (galnac) фосфорамитиды, их конъюгаты с нуклеиновыми кислотами и их применение |
JOP20200092A1 (ar) * | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
TW202336231A (zh) | 2015-05-06 | 2023-09-16 | 美商阿尼拉製藥公司 | 第十二因子(哈格曼因子)(F12)、激肽釋放素B、血漿(夫列契因子)1(KLKB1)及激肽原1(KNG1)iRNA組成物及其使用方法 |
MA45478A (fr) * | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
WO2018191278A2 (fr) | 2017-04-11 | 2018-10-18 | Arbutus Biopharma Corporation | Compositions ciblées |
AU2018254437A1 (en) * | 2017-04-18 | 2019-11-28 | Alnylam Pharmaceuticals, Inc. | Methods for the treatment of subjects having a hepatitis B virus (HBV) infection |
US20220168430A1 (en) | 2019-03-20 | 2022-06-02 | Arbutus Biopharma Corporation | Therapeutic methods for treating hepatitis b |
EP3986456A1 (fr) * | 2019-06-18 | 2022-04-27 | Janssen Sciences Ireland Unlimited Company | Combinaison de vaccins contre le virus de l'hépatite b (hbv) et d'arni ciblant le hbv |
-
2018
- 2018-04-10 WO PCT/US2018/026918 patent/WO2018191278A2/fr unknown
- 2018-04-10 MX MX2019012280A patent/MX2019012280A/es unknown
- 2018-04-10 NZ NZ757927A patent/NZ757927A/en unknown
- 2018-04-10 EP EP21152689.2A patent/EP3950004A1/fr active Pending
- 2018-04-10 SG SG11201909433X patent/SG11201909433XA/en unknown
- 2018-04-10 CA CA3059426A patent/CA3059426A1/fr active Pending
- 2018-04-10 KR KR1020247011466A patent/KR20240049852A/ko not_active Application Discontinuation
- 2018-04-10 BR BR112019021359A patent/BR112019021359A2/pt unknown
- 2018-04-10 KR KR1020197033270A patent/KR102656438B1/ko active IP Right Grant
- 2018-04-10 AU AU2018250553A patent/AU2018250553A1/en active Pending
- 2018-04-10 CN CN201880038780.5A patent/CN110741087B/zh active Active
- 2018-04-10 EP EP18720744.4A patent/EP3610017A2/fr active Pending
- 2018-04-10 US US16/603,771 patent/US11427823B2/en active Active
- 2018-04-10 MA MA052546A patent/MA52546A/fr unknown
- 2018-04-10 JP JP2019555936A patent/JP2020516296A/ja active Pending
- 2018-04-10 CN CN202410526906.0A patent/CN118460536A/zh active Pending
- 2018-04-11 TW TW112118993A patent/TW202413641A/zh unknown
- 2018-04-11 TW TW107112376A patent/TWI805577B/zh active
-
2019
- 2019-10-11 PH PH12019502333A patent/PH12019502333A1/en unknown
-
2022
- 2022-06-30 US US17/854,575 patent/US12043833B2/en active Active
- 2022-11-02 JP JP2022176285A patent/JP2023017897A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PH12019502333A1 (en) | 2020-09-28 |
NZ757927A (en) | 2023-07-28 |
TW201842183A (zh) | 2018-12-01 |
WO2018191278A3 (fr) | 2018-11-22 |
US11427823B2 (en) | 2022-08-30 |
MX2019012280A (es) | 2020-01-23 |
CN110741087A (zh) | 2020-01-31 |
EP3610017A2 (fr) | 2020-02-19 |
JP2020516296A (ja) | 2020-06-11 |
US20200407724A1 (en) | 2020-12-31 |
KR20240049852A (ko) | 2024-04-17 |
US12043833B2 (en) | 2024-07-23 |
TW202413641A (zh) | 2024-04-01 |
SG11201909433XA (en) | 2019-11-28 |
CN118460536A (zh) | 2024-08-09 |
EP3950004A1 (fr) | 2022-02-09 |
US20230110295A1 (en) | 2023-04-13 |
KR20200005555A (ko) | 2020-01-15 |
TWI805577B (zh) | 2023-06-21 |
CN110741087B (zh) | 2024-05-14 |
WO2018191278A2 (fr) | 2018-10-18 |
AU2018250553A1 (en) | 2019-11-07 |
BR112019021359A2 (pt) | 2020-05-05 |
KR102656438B1 (ko) | 2024-04-12 |
CA3059426A1 (fr) | 2018-10-18 |
JP2023017897A (ja) | 2023-02-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA52546A (fr) | Compositions ciblées | |
MA49519A (fr) | Compositions agricoles | |
DK3688162T3 (da) | Formuleringer | |
DK3731771T3 (da) | V462033dk00 | |
MA46458A (fr) | Compositions debacillus thuringiensis | |
DK3697376T3 (da) | Sammensætning | |
DK3361870T3 (da) | Fungicidsammensætninger | |
DE202018003363U8 (de) | Handgelenkssphygmomanometer | |
DK3416996T3 (da) | Hærdelig sammensætning | |
CL2018000524S1 (es) | Golilla | |
DK3334726T3 (da) | Plinabulinsammensætninger | |
MA50657A (fr) | Formulations de niraparib | |
DK3351526T3 (da) | Diisopentylterephthalat | |
DK3250182T3 (da) | Dispergible sammensætninger | |
DK3528902T3 (da) | Ringegelsammensætning | |
DK3568655T3 (da) | Rekuperator | |
DK3571580T3 (da) | Load-logical-and-shift-guarded-instruktion | |
DK3612237T3 (da) | Genterapi | |
DK3451829T3 (da) | Antimikrobielle sammensætninger | |
DK3568506T3 (da) | Offeranode | |
MA50068A (fr) | Formulations de copanlisib | |
DK3316857T3 (da) | Multifasiske sammensætninger | |
DK3393254T3 (da) | Sammensætning | |
DK3609464T3 (da) | Xanthohumolbaserede sammensætninger | |
DK3528791T3 (da) | Dispergible sammensætninger |