SG11201909433XA - Targeted compositions - Google Patents
Targeted compositionsInfo
- Publication number
- SG11201909433XA SG11201909433XA SG11201909433XA SG11201909433XA SG 11201909433X A SG11201909433X A SG 11201909433XA SG 11201909433X A SG11201909433X A SG 11201909433XA SG 11201909433X A SG11201909433X A SG 11201909433XA
- Authority
- SG
- Singapore
- Prior art keywords
- parkway
- burnaby
- british columbia
- glenlyon
- international
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 2
- 108020004459 Small interfering RNA Proteins 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000008685 targeting Effects 0.000 abstract 2
- 229940126670 AB-836 Drugs 0.000 abstract 1
- 235000007652 Arbutus Nutrition 0.000 abstract 1
- 240000008327 Arbutus unedo Species 0.000 abstract 1
- 208000005331 Hepatitis D Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000006454 hepatitis Diseases 0.000 abstract 1
- 231100000283 hepatitis Toxicity 0.000 abstract 1
- 208000002672 hepatitis B Diseases 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000007790 solid phase Substances 0.000 abstract 1
- 238000010189 synthetic method Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 239000002023 wood Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/344—Position-specific modifications, e.g. on every purine, at the 3'-end
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3521—Methyl
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/353—Nature of the modification linked to the nucleic acid via an atom other than carbon
- C12N2310/3533—Halogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials Applied To Surfaces To Minimize Adherence Of Mist Or Water (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762484247P | 2017-04-11 | 2017-04-11 | |
US201762525071P | 2017-06-26 | 2017-06-26 | |
PCT/US2018/026918 WO2018191278A2 (fr) | 2017-04-11 | 2018-04-10 | Compositions ciblées |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201909433XA true SG11201909433XA (en) | 2019-11-28 |
Family
ID=62063656
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201909433X SG11201909433XA (en) | 2017-04-11 | 2018-04-10 | Targeted compositions |
Country Status (15)
Country | Link |
---|---|
US (2) | US11427823B2 (fr) |
EP (2) | EP3610017A2 (fr) |
JP (2) | JP2020516296A (fr) |
KR (2) | KR20240049852A (fr) |
CN (2) | CN118460536A (fr) |
AU (1) | AU2018250553A1 (fr) |
BR (1) | BR112019021359A2 (fr) |
CA (1) | CA3059426A1 (fr) |
MA (1) | MA52546A (fr) |
MX (1) | MX2019012280A (fr) |
NZ (1) | NZ757927A (fr) |
PH (1) | PH12019502333A1 (fr) |
SG (1) | SG11201909433XA (fr) |
TW (2) | TWI805577B (fr) |
WO (1) | WO2018191278A2 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MA45478A (fr) * | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
CN118460536A (zh) | 2017-04-11 | 2024-08-09 | 阿布特斯生物制药公司 | 靶向组合物 |
JP7360716B2 (ja) | 2017-12-01 | 2023-10-13 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、当該核酸を含む組成物および複合体ならびに調製方法と使用 |
WO2019105418A1 (fr) | 2017-12-01 | 2019-06-06 | 苏州瑞博生物技术有限公司 | Oligonucléotide double brin, composition et conjugué comprenant un oligonucléotide double brin, procédé de préparation et utilisation associés |
CN118291456A (zh) | 2017-12-01 | 2024-07-05 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
US11414665B2 (en) | 2017-12-01 | 2022-08-16 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
EP3842534A4 (fr) | 2018-08-21 | 2022-07-06 | Suzhou Ribo Life Science Co., Ltd. | Acide nucléique, composition et conjugué contenant un acide nucléique et leur procédé d'utilisation |
CN111655297A (zh) | 2018-09-30 | 2020-09-11 | 苏州瑞博生物技术有限公司 | 一种siRNA缀合物及其制备方法和用途 |
WO2020093053A1 (fr) * | 2018-11-02 | 2020-05-07 | Arbutus Biopharma Corporation | Conjugués ciblés bivalents |
KR20210120988A (ko) * | 2018-11-02 | 2021-10-07 | 제네반트 사이언시즈 게엠베하 | 치료 방법 |
CN113874373A (zh) * | 2019-03-20 | 2021-12-31 | 阿布特斯生物制药公司 | 用于治疗乙型肝炎的治疗方法 |
US20230313195A1 (en) * | 2019-05-22 | 2023-10-05 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, pharmaceutical composition, conjugate, preparation method, and use |
AU2020297008A1 (en) | 2019-06-18 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis B virus (HBV) vaccines and HBV-targeting RNAi |
MX2022006846A (es) * | 2019-12-06 | 2022-10-21 | Genevant Sciences Gmbh | Conjugados y metodos para tratar la fibrosis hepatica. |
WO2021127214A1 (fr) * | 2019-12-20 | 2021-06-24 | Arbutus Biopharma Corporation | Procédés et intermédiaires de synthèse |
EP4240369A1 (fr) * | 2020-11-06 | 2023-09-13 | Arbutus Biopharma Corporation | Conjugués ciblés conprenant un arnsi modifié |
WO2023109945A1 (fr) * | 2021-12-16 | 2023-06-22 | 上海拓界生物医药科技有限公司 | Arn double brin, son procédé de préparation et son application |
AU2023209536A1 (en) * | 2022-01-20 | 2024-08-08 | Chengdu Xinzhenghe Pharmaceutical Technology Co. Ltd | Targeting ligand and use thereof |
CN116917477B (zh) * | 2022-01-30 | 2024-04-09 | 大睿生物医药科技(上海)有限公司 | 含有n-乙酰半乳糖胺的靶向配体 |
WO2023178144A2 (fr) * | 2022-03-16 | 2023-09-21 | Empirico Inc. | Compositions de galnac pour améliorer la biodisponibilité de l'arnsi |
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US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
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DK3301177T3 (da) * | 2011-11-18 | 2020-06-15 | Alnylam Pharmaceuticals Inc | Rnai-midler, sammensætninger og fremgangsmåder til anvendelse deraf til behandling af transthyretin (ttr)-forbundne sygdomme |
DK3366775T3 (da) | 2011-11-18 | 2022-08-01 | Alnylam Pharmaceuticals Inc | Modificerede rnai-midler |
EP2920304B1 (fr) | 2012-11-15 | 2019-03-06 | Roche Innovation Center Copenhagen A/S | Conjugués d'oligonucléotides |
EP2992098B1 (fr) | 2013-05-01 | 2019-03-27 | Ionis Pharmaceuticals, Inc. | Compositions et méthodes pour moduler l'expression de hbv et de ttr |
EP3730619A1 (fr) | 2013-06-21 | 2020-10-28 | Ionis Pharmaceuticals, Inc. | Compositions et procédés de modulation d'acides nucléiques cibles |
SG10201908122XA (en) | 2013-06-27 | 2019-10-30 | Roche Innovation Ct Copenhagen As | Antisense oligomers and conjugates targeting pcsk9 |
WO2015042564A1 (fr) | 2013-09-23 | 2015-03-26 | Alnylam Pharmaceuticals, Inc. | Méthodes pour le traitement ou la prévention de maladies associées à la transthyrétine (ttr) |
DK3137091T3 (da) | 2014-05-01 | 2021-01-25 | Ionis Pharmaceuticals Inc | Konjugater af modificerede antisense-oligonukleotider og anvendelse deraf til modulation af pkk-ekspression |
WO2016055601A1 (fr) | 2014-10-10 | 2016-04-14 | F. Hoffmann-La Roche Ag | Phosphoramidites galnac, leurs conjugués d'acides nucléiques et leur utilisation |
JOP20200115A1 (ar) | 2014-10-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات)) |
JOP20200092A1 (ar) * | 2014-11-10 | 2017-06-16 | Alnylam Pharmaceuticals Inc | تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها |
BR112017021967A2 (pt) | 2015-05-06 | 2018-07-31 | Alnylam Pharmaceuticals Inc | composições do fator xii (fator hageman) (f12), kallikrein b, plasma (fator fletcher) 1 (klkb1), e kininogen 1 (kng1) irna e métodos de uso dos mesmos |
MA45478A (fr) | 2016-04-11 | 2019-02-20 | Arbutus Biopharma Corp | Compositions de conjugués d'acides nucléiques ciblés |
CN118460536A (zh) | 2017-04-11 | 2024-08-09 | 阿布特斯生物制药公司 | 靶向组合物 |
SG11201909572QA (en) * | 2017-04-18 | 2019-11-28 | Alnylam Pharmaceuticals Inc | Methods for the treatment of subjects having a hepatitis b virus (hbv) infection |
CN113874373A (zh) | 2019-03-20 | 2021-12-31 | 阿布特斯生物制药公司 | 用于治疗乙型肝炎的治疗方法 |
AU2020297008A1 (en) * | 2019-06-18 | 2022-02-17 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis B virus (HBV) vaccines and HBV-targeting RNAi |
-
2018
- 2018-04-10 CN CN202410526906.0A patent/CN118460536A/zh active Pending
- 2018-04-10 NZ NZ757927A patent/NZ757927A/en unknown
- 2018-04-10 CA CA3059426A patent/CA3059426A1/fr active Pending
- 2018-04-10 EP EP18720744.4A patent/EP3610017A2/fr active Pending
- 2018-04-10 AU AU2018250553A patent/AU2018250553A1/en active Pending
- 2018-04-10 EP EP21152689.2A patent/EP3950004A1/fr active Pending
- 2018-04-10 BR BR112019021359A patent/BR112019021359A2/pt unknown
- 2018-04-10 MX MX2019012280A patent/MX2019012280A/es unknown
- 2018-04-10 JP JP2019555936A patent/JP2020516296A/ja active Pending
- 2018-04-10 KR KR1020247011466A patent/KR20240049852A/ko not_active Application Discontinuation
- 2018-04-10 KR KR1020197033270A patent/KR102656438B1/ko active IP Right Grant
- 2018-04-10 CN CN201880038780.5A patent/CN110741087B/zh active Active
- 2018-04-10 MA MA052546A patent/MA52546A/fr unknown
- 2018-04-10 SG SG11201909433X patent/SG11201909433XA/en unknown
- 2018-04-10 US US16/603,771 patent/US11427823B2/en active Active
- 2018-04-10 WO PCT/US2018/026918 patent/WO2018191278A2/fr unknown
- 2018-04-11 TW TW107112376A patent/TWI805577B/zh active
- 2018-04-11 TW TW112118993A patent/TW202413641A/zh unknown
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2019
- 2019-10-11 PH PH12019502333A patent/PH12019502333A1/en unknown
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2022
- 2022-06-30 US US17/854,575 patent/US12043833B2/en active Active
- 2022-11-02 JP JP2022176285A patent/JP2023017897A/ja active Pending
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AU2018250553A1 (en) | 2019-11-07 |
MX2019012280A (es) | 2020-01-23 |
CN110741087B (zh) | 2024-05-14 |
KR20240049852A (ko) | 2024-04-17 |
JP2023017897A (ja) | 2023-02-07 |
MA52546A (fr) | 2020-02-19 |
TW202413641A (zh) | 2024-04-01 |
EP3610017A2 (fr) | 2020-02-19 |
WO2018191278A2 (fr) | 2018-10-18 |
EP3950004A1 (fr) | 2022-02-09 |
BR112019021359A2 (pt) | 2020-05-05 |
TWI805577B (zh) | 2023-06-21 |
US12043833B2 (en) | 2024-07-23 |
US20230110295A1 (en) | 2023-04-13 |
JP2020516296A (ja) | 2020-06-11 |
WO2018191278A3 (fr) | 2018-11-22 |
CN118460536A (zh) | 2024-08-09 |
US20200407724A1 (en) | 2020-12-31 |
PH12019502333A1 (en) | 2020-09-28 |
KR102656438B1 (ko) | 2024-04-12 |
NZ757927A (en) | 2023-07-28 |
CN110741087A (zh) | 2020-01-31 |
US11427823B2 (en) | 2022-08-30 |
CA3059426A1 (fr) | 2018-10-18 |
TW201842183A (zh) | 2018-12-01 |
KR20200005555A (ko) | 2020-01-15 |
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