UA121017C2 - Композиція і спосіб моделювання експресії hbv - Google Patents
Композиція і спосіб моделювання експресії hbv Download PDFInfo
- Publication number
- UA121017C2 UA121017C2 UAA201511840A UAA201511840A UA121017C2 UA 121017 C2 UA121017 C2 UA 121017C2 UA A201511840 A UAA201511840 A UA A201511840A UA A201511840 A UAA201511840 A UA A201511840A UA 121017 C2 UA121017 C2 UA 121017C2
- Authority
- UA
- Ukraine
- Prior art keywords
- nucleoside
- group
- oligonucleotide
- antisense
- hepmer
- Prior art date
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361818442P | 2013-05-01 | 2013-05-01 | |
| US201361823826P | 2013-05-15 | 2013-05-15 | |
| US201361843887P | 2013-07-08 | 2013-07-08 | |
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| PCT/US2014/036463 WO2014179627A2 (en) | 2013-05-01 | 2014-05-01 | Compositions and methods for modulating hbv and ttr expression |
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| PL3137605T3 (pl) | 2014-05-01 | 2021-04-19 | Ionis Pharmaceuticals, Inc. | Kompozycje i sposoby modulowania ekspresji białka angiopoetynopodobnego 3 |
| CA2943894A1 (en) | 2014-05-01 | 2015-11-05 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating complement factor b expression |
| ES2812099T3 (es) | 2014-05-01 | 2021-03-16 | Ionis Pharmaceuticals Inc | Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento |
| MX377141B (es) | 2014-05-01 | 2025-03-07 | Ionis Pharmaceuticals Inc | Composiciones y metodos para modular la expresion de pkk. |
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| WO2015188194A1 (en) | 2014-06-06 | 2015-12-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for enhanced intestinal absorption of conjugated oligomeric compounds |
| CN113952353A (zh) * | 2015-11-06 | 2022-01-21 | Ionis制药公司 | 调节载脂蛋白(a)表达 |
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