BE2016C008I2 - - Google Patents

Download PDF

Info

Publication number
BE2016C008I2
BE2016C008I2 BE2016C008C BE2016C008C BE2016C008I2 BE 2016C008 I2 BE2016C008 I2 BE 2016C008I2 BE 2016C008 C BE2016C008 C BE 2016C008C BE 2016C008 C BE2016C008 C BE 2016C008C BE 2016C008 I2 BE2016C008 I2 BE 2016C008I2
Authority
BE
Belgium
Prior art keywords
abms
relates
present
nucleic acid
methods
Prior art date
Application number
BE2016C008C
Other languages
English (en)
Original Assignee
Roche Glycart Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34572912&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE2016C008(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Glycart Ag filed Critical Roche Glycart Ag
Publication of BE2016C008I2 publication Critical patent/BE2016C008I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40—Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01144—Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase (2.4.1.144)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
BE2016C008C 2003-11-05 2016-03-03 BE2016C008I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51709603P 2003-11-05 2003-11-05
EP04798998A EP1692182B1 (fr) 2003-11-05 2004-11-05 Molecules fixatrices d'antigenes presentant une affinite de fixation du recepteur de fc et une fonction effectrice accrues
EP09004064.3A EP2077282B1 (fr) 2003-11-05 2004-11-05 Molécules de liaison d'antigène avec affinité de liaison de récepteur Fc améliorée et fonction d'effecteur

Publications (1)

Publication Number Publication Date
BE2016C008I2 true BE2016C008I2 (fr) 2021-08-16

Family

ID=34572912

Family Applications (1)

Application Number Title Priority Date Filing Date
BE2016C008C BE2016C008I2 (fr) 2003-11-05 2016-03-03

Country Status (40)

Country Link
US (7) US9296820B2 (fr)
EP (5) EP2077282B1 (fr)
JP (5) JP4653109B2 (fr)
KR (3) KR101364902B1 (fr)
CN (4) CN1902231B (fr)
AT (1) ATE463513T1 (fr)
AU (1) AU2004287643C1 (fr)
BE (1) BE2016C008I2 (fr)
BR (2) BR122020013239B1 (fr)
CA (1) CA2544865C (fr)
CR (1) CR11848A (fr)
CY (6) CY1110301T1 (fr)
DE (1) DE602004026470D1 (fr)
DK (5) DK1692182T3 (fr)
EA (4) EA036531B1 (fr)
EC (2) ECSP066603A (fr)
ES (5) ES2615507T3 (fr)
FR (1) FR15C0076I2 (fr)
HK (4) HK1167682A1 (fr)
HR (5) HRP20100303T1 (fr)
HU (5) HUE042914T2 (fr)
IL (4) IL175367A (fr)
LT (4) LT2348051T (fr)
LU (2) LU92632I2 (fr)
MA (1) MA31040B1 (fr)
ME (3) ME01775B (fr)
MX (2) MXPA06004836A (fr)
NL (1) NL300801I2 (fr)
NO (5) NO346533B1 (fr)
NZ (2) NZ588860A (fr)
PL (5) PL2380910T3 (fr)
PT (5) PT2380911T (fr)
RS (5) RS54450B1 (fr)
SG (3) SG160348A1 (fr)
SI (5) SI2380910T1 (fr)
TN (1) TNSN06126A1 (fr)
TR (2) TR201903329T4 (fr)
UA (1) UA91823C2 (fr)
WO (1) WO2005044859A2 (fr)
ZA (1) ZA200604547B (fr)

Families Citing this family (764)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3657899A (en) * 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
NZ592087A (en) 2001-08-03 2012-11-30 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
WO2005000901A2 (fr) 2003-05-09 2005-01-06 Duke University Anticorps specifiques de cd20 et leurs methodes d'utilisation
EA036531B1 (ru) 2003-11-05 2020-11-19 Роше Гликарт Аг Гуманизированное антитело типа ii к cd20 (варианты), фармацевтическая композиция, содержащая эти варианты антитела, и их применение
BRPI0513100A (pt) * 2004-07-22 2007-10-23 Genentech Inc métodos de tratamento da sìndrome de sjÍgren e artigos manufaturados
EA012464B1 (ru) 2004-08-04 2009-10-30 Эпплайд Молекьюлар Эволюшн, Инк. Антитело против cd20 и его применение
WO2006041680A2 (fr) * 2004-10-05 2006-04-20 Genentech, Inc. Methode de traitement de l'angeite
NZ556286A (en) 2005-02-07 2010-11-26 Glycart Biotechnology Ag Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
EP1888649A2 (fr) * 2005-05-09 2008-02-20 GlycArt Biotechnology AG Molecules de liaison a l'antigene possedant des zones fc modifiees et une liaison alteree aux recepteurs fc
JP2008545958A (ja) * 2005-05-20 2008-12-18 ジェネンテック・インコーポレーテッド 自己免疫性疾患の被検体の生体試料の前処理
WO2006133148A2 (fr) * 2005-06-03 2006-12-14 Genentech, Inc. Methode de production d'anticorps presentant une fonction amelioree
ES2530265T3 (es) 2005-07-21 2015-02-27 Genmab A/S Ensayos de potencia de unión de una sustancia medicamentosa de anticuerpo a un receptor FC
US20070071745A1 (en) * 2005-08-26 2007-03-29 Pablo Umana Modified antigen binding molecules with altered cell signaling activity
AU2012216702B2 (en) * 2005-08-26 2014-12-04 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
US8470318B2 (en) * 2005-11-07 2013-06-25 The Rockefeller University Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
AU2006312148B2 (en) * 2005-11-07 2012-04-12 The Rockefeller University Reagents, methods and systems for selecting a cytotoxic antibody or variant thereof
US20080206246A1 (en) * 2006-04-05 2008-08-28 Ravetch Jeffrey V Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
CN105859886A (zh) 2005-12-02 2016-08-17 健泰科生物技术公司 牵涉与il-22和il-22r结合的抗体的组合物和方法
RU2450020C2 (ru) 2006-01-05 2012-05-10 Дженентек, Инк. АНТИТЕЛА ПРОТИВ EphB4 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US20070249014A1 (en) 2006-02-10 2007-10-25 Invitrogen Corporation Labeling and detection of post translationally modified proteins
AR059851A1 (es) 2006-03-16 2008-04-30 Genentech Inc Anticuerpos de la egfl7 y metodos de uso
EP2815768A3 (fr) * 2006-04-05 2015-01-14 The Rockefeller University Polypeptides présentant des propriétés anti-inflammatoires accrues et des propriétés cytotoxiques réduites et procédés afférents
AR060978A1 (es) 2006-05-30 2008-07-23 Genentech Inc Anticuerpos e inmunoconjugados y sus usos
CA2654304A1 (fr) * 2006-06-06 2007-12-13 Genentech, Inc. Compositions et procedes destines a moduler le developpement vasculaire
AR062223A1 (es) 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
MX2009003774A (es) 2006-10-12 2009-04-22 Genentech Inc Anticuerpos para linfotoxina-alfa.
SI2502938T1 (sl) 2006-10-27 2015-05-29 Genentech, Inc. Protitelesa in imunokonjugati in njihove uporabe
US8465741B2 (en) * 2006-12-20 2013-06-18 Mmrglobal, Inc. Antibodies and methods for making and using them
AU2013202392B2 (en) * 2006-12-20 2016-02-25 Mmrglobal, Inc. Antibodies and methods for making and using them
ES2426158T3 (es) 2007-01-22 2013-10-21 Genentech, Inc. Precipitación con polielectrolito y purificación de anticuerpos
EP2125013A4 (fr) * 2007-01-26 2010-04-07 Bioinvent Int Ab Inhibiteurs de la signalisation dll4 et utilisations associees
CA2676766A1 (fr) 2007-02-09 2008-08-21 Genentech, Inc. Anticorps anti-robo4 et utilisations de ceux-ci
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
FR2915398B1 (fr) * 2007-04-25 2012-12-28 Lab Francais Du Fractionnement "ensemble de moyens pour le traitement d'une pathologie maligne, d'une maladie auto-immune ou d'une maladie infectieuse"
EP2068927B1 (fr) 2007-05-14 2015-10-21 MedImmune, LLC Methodes de reduction de niveaux d'eosinophiles
NZ581468A (en) 2007-06-25 2012-09-28 Esbatech Alcon Biomed Res Unit Methods of modifying antibodies, and modified antibodies with improved functional properties
TW200918089A (en) 2007-07-16 2009-05-01 Genentech Inc Humanized anti-CD79b antibodies and immunoconjugates and methods of use
JP5469600B2 (ja) 2007-07-16 2014-04-16 ジェネンテック， インコーポレイテッド 抗ＣＤ７９ｂ抗体及びイムノコンジュゲートとその使用方法
KR101234436B1 (ko) * 2007-09-05 2013-02-18 로슈 글리카트 아게 유형 ⅰ 및 유형 ⅱ 항-ｃｄ２０ 항체를 사용하는 병용 치료요법
CL2008002886A1 (es) 2007-09-26 2009-12-04 Chugai Pharmaceutical Co Ltd Region constante de un anticuerpo humano; anticuerpo anti-receptor de interleucina-6 (il-6) y composicion farmaceutica que la comprende.
US20090098118A1 (en) * 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090110688A1 (en) * 2007-10-24 2009-04-30 Georg Fertig Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor
SI2514436T1 (en) 2007-11-07 2018-04-30 Genentech, Inc. IL-22 for use in the treatment of microbial diseases
AR069501A1 (es) 2007-11-30 2010-01-27 Genentech Inc Anticuerpos anti- vegf (factor de crecimiento endotelial vascular)
KR101247418B1 (ko) * 2007-12-21 2013-03-25 에프. 호프만-라 로슈 아게 항체 제형
JP2011507897A (ja) * 2007-12-21 2011-03-10 ジェネンテック， インコーポレイテッド リツキシマブ抵抗性関節リウマチ患者の治療
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
SI2657253T1 (sl) 2008-01-31 2017-10-30 Genentech, Inc. Protitelesa proti CD79b in imunokonjugati in postopki za uporabo
AR072947A1 (es) * 2008-03-25 2010-10-06 Glycart Biotechnology Ag Terapia de combinacion de un anticuerpo anti-cd20 de tipo ii con citotoxicidad, celular dependiente de anticuerpos (ccda) aumentada, composicion farmaceutica, anticuerpo anti-cd20 de tipo ii
EP2631302A3 (fr) * 2008-03-31 2014-01-08 Genentech, Inc. Compositions et procédés pour traiter et diagnostiquer l'asthme
CN102037356A (zh) * 2008-04-22 2011-04-27 洛克菲勒大学 鉴定抗炎化合物的方法
WO2009134738A1 (fr) * 2008-04-29 2009-11-05 Genentech, Inc. Réponses à des immunisations chez des patients atteints de polyarthrite rhumatoïde traités avec un anticorps anti-cd20
KR101054362B1 (ko) * 2008-07-03 2011-08-05 재단법인 목암생명공학연구소 재조합 단백질의 푸코스 함량을 감소시키는 방법
JP5986745B2 (ja) 2008-07-15 2016-09-06 アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ Ｐｔｆｅ様のアルミニウム・コート・ガラススライド上のグリカンアレイおよび関連する方法
TW201014605A (en) * 2008-09-16 2010-04-16 Genentech Inc Methods for treating progressive multiple sclerosis
KR20190025057A (ko) 2008-10-14 2019-03-08 제넨테크, 인크. 이뮤노글로불린 변이체 및 그의 용도
WO2010075249A2 (fr) 2008-12-22 2010-07-01 Genentech, Inc. Méthode de traitement de la polyarthrite rhumatoïde avec des antagonistes de cellules b
MX2011006870A (es) 2008-12-23 2011-07-19 Genentech Inc Variantes de inmunoglobulina con union alterada a proteina a.
ES2572728T3 (es) 2009-03-20 2016-06-02 F. Hoffmann-La Roche Ag Anticuerpos anti-HER biespecíficos
CA2754163C (fr) 2009-03-25 2019-04-09 Genentech, Inc. Anticorps anti-fgfr3 et procedes d'utilisation de ceux-ci
NZ594343A (en) 2009-03-25 2013-10-25 Genentech Inc Novel anti-alpha5beta1 antibodies and uses thereof
AR075982A1 (es) * 2009-03-31 2011-05-11 Roche Glycart Ag Terapia de combinacion de un anticuerpo afucosilado y una o mas de las citoquinas seleccionadas de gm- csf humano, m -csf humano y/o il-3 humano y composicion
CA2756244A1 (fr) 2009-04-02 2010-10-07 Roche Glycart Ag Anticorps multispecifiques renfermant des anticorps de longueur entiere et des fragments fab a chaine unique
MX2011010166A (es) 2009-04-07 2011-10-11 Roche Glycart Ag Anticuerpos biespecificos anti-erbb-3/anti-c-met.
EP2417156B1 (fr) 2009-04-07 2015-02-11 Roche Glycart AG Anticorps trivalents, bispécifiques
MX2011010169A (es) 2009-04-07 2011-10-11 Roche Glycart Ag Anticuerpos biespecificos anti-erbb-1/anti-c-met.
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
US20100316639A1 (en) 2009-06-16 2010-12-16 Genentech, Inc. Biomarkers for igf-1r inhibitor therapy
KR20120031083A (ko) 2009-07-24 2012-03-29 에프. 호프만-라 로슈 아게 교반기 시스템
TW201106972A (en) 2009-07-27 2011-03-01 Genentech Inc Combination treatments
NZ597531A (en) 2009-07-31 2014-05-30 Genentech Inc Inhibition of tumor metastasis using bv8- or g-csf-antagonists
AU2010281867A1 (en) 2009-08-14 2012-02-02 Roche Glycart Ag Combination therapy of an afucosylated CD20 antibody with fludarabine and/or mitoxantrone
TWI409079B (zh) * 2009-08-14 2013-09-21 Roche Glycart Ag 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法
GB0914691D0 (en) 2009-08-21 2009-09-30 Lonza Biologics Plc Immunoglobulin variants
TWI412375B (zh) 2009-08-28 2013-10-21 Roche Glycart Ag 人類化抗ｃｄｃｐ１抗體
TW201113037A (en) 2009-08-28 2011-04-16 Hoffmann La Roche Antibodies against CDCP1 for the treatment of cancer
US9321823B2 (en) 2009-09-02 2016-04-26 Genentech, Inc. Mutant smoothened and methods of using the same
AR078161A1 (es) 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
RU2015153109A (ru) 2009-09-16 2019-01-15 Дженентек, Инк. Содержащие суперспираль и/или привязку белковые комплексы и их применения
US9096877B2 (en) * 2009-10-07 2015-08-04 Macrogenics, Inc. Fc region-containing polypeptides that exhibit improved effector function due to alterations of the extent of fucosylation, and methods for their use
NZ599337A (en) 2009-10-22 2013-05-31 Genentech Inc Anti-hepsin antibodies and methods using same
WO2011056502A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Compositions du gene recepteur de proteine morphogenetique osseuse type ii et procedes d'utilisation
WO2011056494A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Combinaisons d'antagonistes de la kinase-1 du type récepteur de l'activine et d'antagonistes vegfr3
WO2011056497A1 (fr) 2009-10-26 2011-05-12 Genentech, Inc. Compositions de récepteur de l'activine de type iib et leurs méthodes d'utilisation
AU2010315101B2 (en) 2009-11-04 2016-01-28 Fabrus Llc Methods for affinity maturation-based antibody optimization
RU2585488C2 (ru) 2009-11-05 2016-05-27 Дженентек, Инк. Способы и композиция для секреции гетерологичных полипептидов
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
TWI505836B (zh) 2009-12-11 2015-11-01 Genentech Inc 抗－ｖｅｇｆ－ｃ抗體及其使用方法
DK2516469T3 (en) 2009-12-22 2016-05-02 Roche Glycart Ag ANTI-HER3 antibodies and uses thereof
SI2516465T1 (sl) 2009-12-23 2016-08-31 F. Hoffmann-La Roche Ag Protelesa proti bv8 in uporaba le-teh
CN102933231B (zh) 2010-02-10 2015-07-29 伊缪诺金公司 Cd20抗体及其用途
CN102741695B (zh) 2010-02-11 2015-08-26 霍夫曼-拉罗奇有限公司 3d adcc nk facs测定法
JP5981853B2 (ja) 2010-02-18 2016-08-31 ジェネンテック， インコーポレイテッド ニューレグリンアンタゴニスト及び癌の治療におけるそれらの使用
NZ602040A (en) 2010-03-24 2014-12-24 Genentech Inc Anti-lrp6 antibodies
TW201138821A (en) 2010-03-26 2011-11-16 Roche Glycart Ag Bispecific antibodies
US9441032B2 (en) 2010-04-07 2016-09-13 Agency For Science, Technology And Research Binding molecules against Chikungunya virus and uses thereof
EP2374816B1 (fr) 2010-04-07 2016-09-28 Agency For Science, Technology And Research Molécules liant le virus du Chikungunya et leurs utilisations
WO2011130332A1 (fr) 2010-04-12 2011-10-20 Academia Sinica Puces au glycane pour la recherche par criblage haut débit de virus
CA2795544A1 (fr) 2010-04-27 2011-11-03 Roche Glycart Ag Polytherapie d'un anticorps anti-cd20 afucosyle et d'un inhibiteur de mtor
CA2835489C (fr) 2010-05-10 2018-03-06 Chi-Huey Wong Congeneres de phosphonate de zanamivir ayant une activite antigrippale et determination de la sensibilite a l'oseltamivir d'influenzavirus
WO2011147834A1 (fr) 2010-05-26 2011-12-01 Roche Glycart Ag Anticorps contre cd19 et utilisations associées
BR112012029866A2 (pt) 2010-06-03 2017-03-07 Genentech Inc método para a determinação da presença de uma proteína steap-1
RU2577986C2 (ru) 2010-06-18 2016-03-20 Дженентек, Инк. Антитела против axl и способы их применения
WO2011161119A1 (fr) 2010-06-22 2011-12-29 F. Hoffmann-La Roche Ag Anticorps contre le récepteur du facteur de croissance insulinique i et ses utilisations
WO2011161189A1 (fr) 2010-06-24 2011-12-29 F. Hoffmann-La Roche Ag Anticorps anti-hepsine et leurs procédés d'utilisation
NZ605449A (en) 2010-07-09 2015-03-27 Genentech Inc Anti-neuropilin antibodies and methods of use
MX2013000301A (es) 2010-07-09 2013-05-09 Biogen Idec Hemophilia Inc Factores quimericos de coagulacion.
EP2409993A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté d'une fonction ADCC et d'un profil de glycosylation amélioré
EP2409989A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Procédé pour améliorer le profile de glycosylation d'un anticorps
EP2409712A1 (fr) 2010-07-19 2012-01-25 International-Drug-Development-Biotech Anticorps Anti-CD19 doté de fonctions ADCC et CDC et d'un profil de glycosylation amélioré
FR2962908A1 (fr) 2010-07-20 2012-01-27 Lfb Biotechnologies Formulation d'anticorps anti-cd20
WO2012010582A1 (fr) 2010-07-21 2012-01-26 Roche Glycart Ag Anticorps anti-cxcr5 et leurs méthodes d'utilisation
CN103153341B (zh) 2010-08-03 2015-05-27 霍夫曼-拉罗奇有限公司 慢性淋巴细胞性白血病(cll)生物标志物
CA2805564A1 (fr) 2010-08-05 2012-02-09 Stefan Jenewein Proteine de fusion anticorps anti-cmh cytokine antivirale
EP3578205A1 (fr) 2010-08-06 2019-12-11 ModernaTX, Inc. Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale
BR112013002444A2 (pt) 2010-08-13 2016-05-24 Roche Glycart Ag anticorpo, polinucleotídeo e polipeotídeo isolados, composição, vetor, cécula hospedeira, conjulgado de anticorpo, formulação farmacêutica, uso do anticorpo, métodos para produzir um anticorpo, tratar um indivíduo, induzir a lise celular de uma célula tumorosa e diagnosticar uma doença em um indivíduo
SG187746A1 (en) 2010-08-13 2013-03-28 Roche Glycart Ag Anti-fap antibodies and methods of use
WO2012022734A2 (fr) 2010-08-16 2012-02-23 Medimmune Limited Anticorps anti-icam-1 et procédés d'utilisation
TW201208703A (en) 2010-08-17 2012-03-01 Roche Glycart Ag Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
NZ604510A (en) 2010-08-17 2013-10-25 Csl Ltd Dilutable biocidal compositions and methods of use
WO2012025530A1 (fr) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Anticorps bispécifiques comprenant un fragment fv stabilisé par bisulfure
CA2805054A1 (fr) 2010-08-25 2012-03-01 F. Hoffmann-La Roche Ag Anticorps contre il-18r1 et leurs utilisations
SG10201408229WA (en) 2010-08-31 2015-02-27 Genentech Inc Biomarkers and methods of treatment
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
WO2012047968A2 (fr) 2010-10-05 2012-04-12 Genentech, Inc. Mutant smoothened et ses procédés d'utilisation
EP3351559A3 (fr) 2010-11-08 2018-10-31 F. Hoffmann-La Roche AG Anticorps du récepteur anti-il-6 administré par voie sous-cutanée
WO2012064836A1 (fr) 2010-11-10 2012-05-18 Genentech, Inc. Méthodes et compositions pour l'immunothérapie de maladies neurales
SI2646470T1 (sl) 2010-11-30 2017-05-31 F. Hoffmann-La Roche Ag Protitelesa proti receptorjem antitransferina in njihova uporaba za prenos terapevtskega enoverižnega variabilnega fragmenta (scfv) prek krvno-možganske pregrade
CA2819436A1 (fr) 2010-12-16 2012-06-21 Roche Glycart Ag Therapie d'association d'un anticorps cd20 afucosyle avec un inhibiteur mdm2
AU2011343570B2 (en) 2010-12-16 2016-11-03 Genentech, Inc. Diagnosis and treatments relating to TH2 inhibition
MX345519B (es) 2010-12-20 2017-02-01 Genentech Inc Anticuerpos anti-mesotelina e inmunoconjugados.
MA34818B1 (fr) 2010-12-22 2014-01-02 Genentech Inc Anticorps anti-pcsk9 et procédés d'utilisation
SG191153A1 (en) 2010-12-23 2013-07-31 Hoffmann La Roche Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
CA2824252A1 (fr) 2011-02-10 2012-08-16 Roche Glycart Ag Immunotherapie amelioree
ES2549638T3 (es) 2011-02-28 2015-10-30 F. Hoffmann-La Roche Ag Proteínas de unión a antígeno
CN103403025B (zh) 2011-02-28 2016-10-12 弗·哈夫曼-拉罗切有限公司 单价抗原结合蛋白
PT2691417T (pt) 2011-03-29 2018-10-31 Roche Glycart Ag Variantes de fc de anticorpos
EP2691101A2 (fr) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Administration et formulation d'acides nucléiques génétiquement modifiés
JP2014516511A (ja) 2011-04-07 2014-07-17 ジェネンテック， インコーポレイテッド 抗ｆｇｆｒ４抗体及び使用方法
WO2012146630A1 (fr) 2011-04-29 2012-11-01 F. Hoffmann-La Roche Ag Polypeptides acylés en position n-terminale, leurs procédés de préparation et leurs utilisations
JP5987053B2 (ja) 2011-05-12 2016-09-06 ジェネンテック， インコーポレイテッド フレームワークシグネチャーペプチドを用いて動物サンプルにおける治療抗体を検出するための多重反応モニタリングｌｃ−ｍｓ／ｍｓ法
WO2012158704A1 (fr) 2011-05-16 2012-11-22 Genentech, Inc. Agonistes de fgfr1 et leurs procédés d'utilisation
AR086924A1 (es) 2011-06-15 2014-01-29 Hoffmann La Roche Anticuerpos anti-receptor de epo humano y los metodos para su utilizacion
SG195077A1 (en) 2011-06-22 2013-12-30 Hoffmann La Roche Removal of target cells by circulating virus-specific cytotoxic t-cells using mhc class i comprising complexes
FR2976811A1 (fr) 2011-06-22 2012-12-28 Lfb Biotechnologies Utilisation d'un anticorps anti-cd20 a haute adcc pour le traitement de la maladie de waldenstrom
WO2013003680A1 (fr) 2011-06-30 2013-01-03 Genentech, Inc. Formulations d'anticorps anti-c-met
CN103890008A (zh) 2011-08-17 2014-06-25 霍夫曼-拉罗奇有限公司 在顽固性肿瘤中抑制血管发生
MX2014001766A (es) 2011-08-17 2014-05-01 Genentech Inc Anticuerpos de neuregulina y sus usos.
US9309306B2 (en) 2011-08-23 2016-04-12 Roche Glycart Ag Anti-MCSP antibodies
KR101870555B1 (ko) 2011-08-23 2018-06-22 로슈 글리카트 아게 T 세포 활성화 항원 및 종양 항원에 대해 특이적인 이중특이적 항체 및 이의 사용 방법
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
KR20140068062A (ko) 2011-09-15 2014-06-05 제넨테크, 인크. 분화의 촉진 방법
MX2014002990A (es) 2011-09-19 2014-05-21 Genentech Inc Tratamientos combinados que comprenden antagonistas de c-met y antagonistas de b-raf.
MX2014002996A (es) 2011-09-23 2014-05-28 Roche Glycart Ag Anticuerpos anti - egfr/anti - igf-1r bisespecificos.
AU2012313594C1 (en) 2011-09-30 2018-05-10 Chugai Seiyaku Kabushiki Kaisha Ion concentration-dependent binding molecule library
CA2850549C (fr) 2011-09-30 2023-03-14 Teva Pharmaceuticals Australia Pty Ltd. Anticorps contre tl1a et leurs utilisations
CA2850624A1 (fr) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Nucleosides, nucleotides et acides nucleiques modifies, et leurs utilisations
US9663573B2 (en) 2011-10-05 2017-05-30 Genentech, Inc. Methods of treating liver conditions using Notch2 antagonists
KR102102862B1 (ko) 2011-10-14 2020-04-22 제넨테크, 인크. 항-HtrA1 항체 및 사용 방법
KR20140084164A (ko) 2011-10-15 2014-07-04 제넨테크, 인크. 암의 치료를 위한 scd1 길항제
WO2013059531A1 (fr) 2011-10-20 2013-04-25 Genentech, Inc. Anticorps anti-gcgr et leurs utilisations
AU2012328980A1 (en) 2011-10-28 2014-04-24 Genentech, Inc. Therapeutic combinations and methods of treating melanoma
US9265817B2 (en) 2011-10-28 2016-02-23 Patrys Limited PAT-LM1 epitopes and methods for using same
EP2776061B1 (fr) 2011-11-07 2019-08-14 MedImmune, LLC Protéines de liaison multispécifiques et multivalentes et leurs utilisations
BR112014012005A2 (pt) 2011-11-21 2017-12-19 Genentech Inc composições, métodos, formulação farmacêutica e artigo
US20130302274A1 (en) * 2011-11-25 2013-11-14 Roche Glycart Ag Combination therapy
EP2788024A1 (fr) 2011-12-06 2014-10-15 F.Hoffmann-La Roche Ag Formulation d'anticorps
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
CA2859667C (fr) 2011-12-20 2022-05-24 Medimmune, Llc Polypeptides modifies pour des echafaudages d'anticorps bispecifiques
KR102280111B1 (ko) 2011-12-22 2021-07-21 에프. 호프만-라 로슈 아게 발현 벡터 구성, 신규한 생산 세포 생성 방법 및 폴리펩티드의 재조합 생산을 위한 그의 용도
KR20140107295A (ko) 2011-12-22 2014-09-04 에프. 호프만-라 로슈 아게 진핵 세포용 전장 항체 표시 시스템 및 그것의 용도
PL2794651T3 (pl) 2011-12-22 2022-12-27 F.Hoffmann-La Roche Ag Kombinacje elementów wektora ekspresyjnego, nowe sposoby generowania komórek produkcyjnych i ich zastosowanie do rekombinowanej produkcji polipeptydów
AR089434A1 (es) 2011-12-23 2014-08-20 Genentech Inc Procedimiento para preparar formulaciones con alta concentracion de proteinas
CN104168920A (zh) 2012-01-18 2014-11-26 霍夫曼-拉罗奇有限公司 使用fgf19调控剂的方法
JP6242813B2 (ja) 2012-01-18 2017-12-06 ジェネンテック， インコーポレイテッド 抗ｌｒｐ５抗体及び使用方法
KR20140127854A (ko) 2012-02-10 2014-11-04 제넨테크, 인크. 단일-쇄 항체 및 다른 이종다량체
BR112014019741A2 (pt) 2012-02-11 2020-12-22 Genentech, Inc Usos de um antagonista da via wnt, uso de uma terapia anticâncer, método de identificação de um indivíduo com câncer, métodos para prever, método de inibição da proliferação de uma célula de câncer, uso de um antagonista da translocação de r-spondina e antagonista da translocação de r-spondina isolado
JP6152120B2 (ja) 2012-02-15 2017-06-21 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｆｃ受容体に基づくアフィニティークロマトグラフィー
JP2015514710A (ja) 2012-03-27 2015-05-21 ジェネンテック， インコーポレイテッド Ｈｅｒ３阻害剤に関する診断及び治療
AR090549A1 (es) 2012-03-30 2014-11-19 Genentech Inc Anticuerpos anti-lgr5 e inmunoconjugados
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
CA2868398A1 (fr) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Polynucleotides modifies pour la production de proteines et de peptides cosmetiques
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
RU2014148162A (ru) 2012-05-01 2016-06-20 Дженентек, Инк. Анти-pmel17 антитела и их иммуноконъюгаты
WO2013170191A1 (fr) 2012-05-11 2013-11-14 Genentech, Inc. Procédés d'utilisation d'antagonistes de biosynthèse de nicotinamide adénine dinucléotide à partir de nicotinamide
BR112014028600B1 (pt) 2012-05-18 2022-11-22 Genentech, Inc Formulações de suspensão compreendendo anticorpo monoclonal de alta concentração, seu método de preparação, seu uso e dispositivo para sua administração subcutânea, e método para produção de um artigo de fabricação
KR102115438B1 (ko) 2012-05-21 2020-05-27 제넨테크, 인크. 혈액-뇌 장벽 수송의 안전성을 개선하는 방법
WO2013177470A1 (fr) 2012-05-23 2013-11-28 Genentech, Inc. Procédé de sélection d'agents thérapeutiques
CN104364266A (zh) 2012-06-15 2015-02-18 霍夫曼-拉罗奇有限公司 抗-pcsk9抗体,制剂,剂量给药,和使用方法
WO2013192131A1 (fr) 2012-06-21 2013-12-27 Indiana University Research And Technology Corporation Polypeptides de fusion de région fc de polypeptide ligand du récepteur d'incrétine et conjugués à fonction effectrice fc modifiée
RU2015100656A (ru) 2012-06-27 2016-08-20 Ф. Хоффманн-Ля Рош Аг Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения
WO2014001324A1 (fr) 2012-06-27 2014-01-03 Hoffmann-La Roche Ag Méthode de sélection et de production d'entités de ciblage personnalisées fortement sélectives et multi-spécifiques renfermant au moins deux entités de liaison différentes et leurs utilisations
WO2014004549A2 (fr) 2012-06-27 2014-01-03 Amgen Inc. Protéines de liaison anti-mésothéline
CA2872192A1 (fr) 2012-07-04 2014-01-09 F. Hoffmann-La Roche Ag Anticorps anti-biotine et procedes d'utilisation correspondants
ES2604012T3 (es) 2012-07-04 2017-03-02 F. Hoffmann-La Roche Ag Conjugados de antígeno-anticuerpo unidos covalentemente
MX353951B (es) 2012-07-04 2018-02-07 Hoffmann La Roche Anticuerpos de anti-teofilina y metodos de uso.
CN110042114A (zh) 2012-07-05 2019-07-23 弗·哈夫曼-拉罗切有限公司 表达和分泌系统
CA2874904A1 (fr) 2012-07-09 2014-01-16 Genentech, Inc. Immunoconjugues comprenant des anticorps anti-cd22
SG11201500087VA (en) 2012-07-09 2015-02-27 Genentech Inc Immunoconjugates comprising anti-cd22 antibodies
SG11201500096YA (en) 2012-07-09 2015-02-27 Genentech Inc Immunoconjugates comprising anti - cd79b antibodies
TW201408698A (zh) 2012-07-09 2014-03-01 Genentech Inc 抗ｃｄ７９ｂ抗體及免疫結合物
HUE056217T2 (hu) 2012-07-13 2022-02-28 Roche Glycart Ag Bispecifikus anti-VEGF/anti-ANG-2 antitestek és ezek alkalmazása szemészeti érbetegségek kezelésében
SG10201800535XA (en) 2012-08-07 2018-02-27 Roche Glycart Ag Composition comprising two antibodies engineered to have reduced and increased effector function
AU2013306098A1 (en) 2012-08-18 2015-02-12 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
WO2014031762A1 (fr) 2012-08-21 2014-02-27 Academia Sinica Composés benzocyclo-octyne et leurs utilisations
CN104520329A (zh) 2012-08-29 2015-04-15 霍夫曼-拉罗奇有限公司 血脑屏障穿梭体
KR20200110711A (ko) * 2012-09-07 2020-09-24 제넨테크, 인크. Ｉｉ형 항-ｃｄ20 항체와 선택적 ｂｃｌ-2 억제제와의 병용 치료요법
JP6273205B2 (ja) 2012-10-05 2018-01-31 協和発酵キリン株式会社 ヘテロダイマータンパク質組成物
WO2014056783A1 (fr) 2012-10-08 2014-04-17 Roche Glycart Ag Anticorps exempts de fc comprenant deux fragments fab et procédés d'utilisation
EP2914629A1 (fr) 2012-11-05 2015-09-09 MAB Discovery GmbH Procédé de fabrication d'anticorps plurispécifiques
EP2727942A1 (fr) 2012-11-05 2014-05-07 MAB Discovery GmbH Anticorps bispécifiques contre le EGFR, HER2 et HER3 humains
EP2727943A1 (fr) 2012-11-05 2014-05-07 MAB Discovery GmbH Anticorps trispécifique contre le EGFR, HER2 et HER3 humains
EP2727941A1 (fr) 2012-11-05 2014-05-07 MAB Discovery GmbH Procédé pour la production d'anticorps multispécifiques
CA2890207A1 (fr) 2012-11-05 2014-05-08 Foundation Medicine, Inc. Nouvelles molecules de fusion de ntrk1 et leurs utilisations
CA2884431A1 (fr) 2012-11-08 2014-05-15 F. Hoffmann-La Roche Ag Proteines de liaison a l'antigene her3 se liant a l'epingle a cheveux beta de her3
WO2014078268A2 (fr) 2012-11-13 2014-05-22 Genentech, Inc. Anticorps anti-hémagglutinine et leurs procédés d'utilisation
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 化学修飾ｍＲＮＡ
EP2931749B1 (fr) 2012-12-17 2019-04-24 Laboratoire Francais du Fractionnement et des Biotechnologies Societe Anonyme Utilisation d'anticorps monoclonaux pour le traitement de l'inflammation et d'infections bacteriennes
JP6475167B2 (ja) 2012-12-21 2019-02-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ジスルフィド結合した多価ｍｈｃクラスｉを含む多機能タンパク質
US20140194368A1 (en) * 2013-01-04 2014-07-10 Beech Tree Labs, Inc. Method of Treating Cancer by Administration of Low Levels of Heat Shock Protein 70 (HSP70)
AR094403A1 (es) 2013-01-11 2015-07-29 Hoffmann La Roche Terapia de combinación de anticuerpos anti-her3
RU2519546C1 (ru) * 2013-01-16 2014-06-10 Общество С Ограниченной Ответственностью "Биоинтегратор" (Ооо "Биоинтегратор") КОНЪЮГАТЫ И МАЛЫЕ МОЛЕКУЛЫ, ВЗАИМОДЕЙСТВУЮЩИЕ С РЕЦЕПТОРОМ CD16а
CA3150658A1 (en) 2013-01-18 2014-07-24 Foundation Medicine, Inc. Methods of treating cholangiocarcinoma
WO2014116749A1 (fr) 2013-01-23 2014-07-31 Genentech, Inc. Anticorps anti-vhc et méthodes d'utilisation correspondantes
CA2899960C (fr) 2013-02-01 2022-05-03 Transbio Ltd Anticorps anti-cd83 et leur utilisation
US9340618B2 (en) 2013-02-07 2016-05-17 Csl Limited IL-11R binding proteins
EP2956480B1 (fr) 2013-02-13 2019-09-04 Laboratoire Français du Fractionnement et des Biotechnologies Anticorps anti-tnf alpha hautement galactosylés et leurs utilisations
JP2016509045A (ja) 2013-02-22 2016-03-24 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト がんを治療し、薬剤耐性を防止する方法
CA2896259A1 (fr) 2013-02-26 2014-09-04 Roche Glycart Ag Anticorps anti-mcsp
RU2015140915A (ru) 2013-02-26 2017-04-03 Роше Гликарт Аг Биспецифические антигенсвязывающие молекулы, активирующие т-клетки
MY192312A (en) 2013-02-26 2022-08-17 Roche Glycart Ag Bispecific t cell activating antigen binding molecules
US9925240B2 (en) 2013-03-06 2018-03-27 Genentech, Inc. Methods of treating and preventing cancer drug resistance
KR102384693B1 (ko) 2013-03-12 2022-04-07 유니버시티 오브 유타 리서치 파운데이션 세포사멸 유도용 조성물 및 방법
BR112015022210A8 (pt) 2013-03-13 2018-01-23 Genentech Inc formulações de anticorpo
US9562099B2 (en) 2013-03-14 2017-02-07 Genentech, Inc. Anti-B7-H4 antibodies and immunoconjugates
WO2014159835A1 (fr) 2013-03-14 2014-10-02 Genentech, Inc. Anticorps et immunoconjugués anti-b7-h4
EP2968540A2 (fr) 2013-03-14 2016-01-20 Genentech, Inc. Combinaisons d'un composé inhibiteur de mek avec un composé inhibiteur de her3/egfr et procédés d'utilisation
CA2905070A1 (fr) 2013-03-14 2014-09-25 Genentech, Inc. Methodes de traitement du cancer et de prevention d'une resistance a un medicament anticancereux
TR201809571T4 (tr) 2013-03-15 2018-07-23 Hoffmann La Roche Ll-22 polipeptidleri ile ıl-22 fc füzyon proteinleri ve kullanım yöntemleri.
MX2015011899A (es) 2013-03-15 2016-05-05 Genentech Inc Metodos para el tratamiento de cáncer y prevención de resistencia a los fármacos para el cáncer.
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
MX2015012872A (es) 2013-03-15 2016-02-03 Ac Immune Sa Anticuerpos anti-tau y metodos de uso.
BR112015021521A2 (pt) 2013-03-15 2017-10-10 Genentech Inc anticorpos anti-crth2 e métodos para seu uso
EP2972373B1 (fr) 2013-03-15 2019-10-09 F.Hoffmann-La Roche Ag Biomarqueurs et méthodes de traitement d'états associés à pd-1 et pd-l1
DK3460054T3 (da) 2013-03-15 2021-01-18 Atyr Pharma Inc Histidyl-tRNA-syntetase-Fc-konjugater
JP6527132B2 (ja) 2013-03-15 2019-06-05 ジェネンテック， インコーポレイテッド 肝臓がんの診断及び治療のための組成物及び方法
UA118028C2 (uk) 2013-04-03 2018-11-12 Рош Глікарт Аг Біспецифічне антитіло, специфічне щодо fap і dr5, антитіло, специфічне щодо dr5, і спосіб їх застосування
CN105164158A (zh) 2013-04-29 2015-12-16 豪夫迈·罗氏有限公司 消除对FcRn-结合的抗-IGF-1R抗体及其在血管性眼病治疗中的用途
RU2687043C2 (ru) 2013-04-29 2019-05-06 Ф. Хоффманн-Ля Рош Аг МОДИФИЦИРОВАННЫЕ АСИММЕТРИЧНЫЕ АНТИТЕЛА, СВЯЗЫВАЮЩИЕ Fc-РЕЦЕПТОР, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
EP2992012B1 (fr) 2013-04-29 2019-07-17 F.Hoffmann-La Roche Ag Anticorps modifiés liés au récepteur fcrn humain et procédés d'utilisation
SG11201509026VA (en) * 2013-05-02 2015-12-30 Hoffmann La Roche Combination therapy of an afucosylated cd20 antibody with a cd22 antibody-drug conjugate
US20140356352A1 (en) * 2013-05-02 2014-12-04 Genentech, Inc. COMBINATION THERAPY OF AN AFUCOSYLATED CD20 ANTIBODY WITH A CD79b ANTIBODY-DRUG CONJUGATE
EP2999716A2 (fr) 2013-05-20 2016-03-30 F. Hoffmann-La Roche AG Anticorps anti-récepteur de transferrine et procédés d'utilisation
US10086054B2 (en) 2013-06-26 2018-10-02 Academia Sinica RM2 antigens and use thereof
EP3013347B1 (fr) 2013-06-27 2019-12-11 Academia Sinica Conjugués de glycane et leur utilisation
EP4036118A1 (fr) 2013-08-01 2022-08-03 Five Prime Therapeutics, Inc. Anticorps anti-fgfr2iiib non fucosilés
US20150093399A1 (en) 2013-08-28 2015-04-02 Bioasis Technologies, Inc. Cns-targeted conjugates having modified fc regions and methods of use thereof
CN105682666B (zh) 2013-09-06 2021-06-01 中央研究院 使用醣脂激活人类iNKT细胞
CN105518027A (zh) 2013-09-17 2016-04-20 豪夫迈·罗氏有限公司 使用抗lgr5抗体的方法
EP3052106A4 (fr) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucléotides codant des polypeptides de modulation immunitaire
WO2015050959A1 (fr) 2013-10-01 2015-04-09 Yale University Anticorps anti-kits et leurs méthodes d'utilisation
KR102501920B1 (ko) 2013-10-02 2023-02-20 메디뮨 엘엘씨 중화 항-인플루엔자 a 항체 및 이의 용도
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
KR20160068855A (ko) 2013-10-11 2016-06-15 제넨테크, 인크. Nsp4 억제제 및 사용 방법
MX2016003744A (es) 2013-10-11 2016-08-11 Us Health Anticuerpos tem8 y su uso.
MX2016003593A (es) 2013-10-11 2016-06-02 Hoffmann La Roche Anticuerpos de cadena ligera variable comun intercambiada de dominio multiespecifico.
MX2016004802A (es) 2013-10-18 2016-07-18 Genentech Inc Anticuerpos anti-r-espondina (anti-rspo) y metodos de uso.
RU2016119425A (ru) 2013-10-23 2017-11-28 Дженентек, Инк. Способы диагностики и лечения эозинофильных заболеваний
AU2014351996B2 (en) 2013-11-21 2020-01-02 F. Hoffmann-La Roche Ag Anti-alpha-synuclein antibodies and methods of use
WO2015082446A1 (fr) 2013-12-02 2015-06-11 F. Hoffmann-La Roche Ag Traitement du cancer à l'aide d'un anticorps anti-cdcp1 et d'un taxane
CN113861293A (zh) 2013-12-09 2021-12-31 爱乐科斯公司 抗Siglec-8抗体及其使用方法
MA39095A1 (fr) 2013-12-13 2018-08-31 Genentech Inc Anticorps et immunoconjugués anti-cd33
EP3083692B1 (fr) 2013-12-17 2020-02-19 F.Hoffmann-La Roche Ag Méthode de traitement des cancers utilisant des antagonists se liant à l'axe pd-1 et des taxanes
WO2015095410A1 (fr) 2013-12-17 2015-06-25 Genentech, Inc. Méthodes de traitement du cancer à l'aide d'antagonistes se liant à l'axe pd-1 et d'anticorps anti-cd20
CA2934028A1 (fr) 2013-12-17 2015-06-25 Genentech, Inc. Polytherapie comprenant des agonistes se liant a ox40 et des antagonistes se liant a l'axe pd-1
DK3083689T3 (da) 2013-12-17 2020-08-03 Genentech Inc Anti-CD3-antistoffer og fremgangsmåder til anvendelse
TWI728373B (zh) 2013-12-23 2021-05-21 美商建南德克公司 抗體及使用方法
EP3089996B1 (fr) 2014-01-03 2021-07-28 F. Hoffmann-La Roche AG Anticorps bispécifiques anti-récepteur des navettes de la barrière hémato-encéphalique/anti-haptène, complexes de ceux-ci et leur utilisation comme navettes de la barrière hémato-encéphalique
BR112016012666A2 (pt) 2014-01-03 2017-09-26 Hoffmann La Roche conjugado, anticorpos, formulação farmacêutica e usos de conjugado
JP6521464B2 (ja) 2014-01-03 2019-05-29 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 共有結合で連結されたポリペプチド毒素−抗体コンジュゲート
WO2015103549A1 (fr) 2014-01-03 2015-07-09 The United States Of America, As Represented By The Secretary Department Of Health And Human Services Anticorps neutralisants dirigés contre la env du vih-1 et leur utilisation
EP3092251B1 (fr) 2014-01-06 2021-01-20 F. Hoffmann-La Roche AG Modules navettes de barrière hémato-encéphalique monovalents
WO2015107026A1 (fr) 2014-01-15 2015-07-23 F. Hoffmann-La Roche Ag Variants de région fc présentant des propriétés modifiées de liaison à fcrn et des propriétés conservées de liaison à la protéine a
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
US9982041B2 (en) 2014-01-16 2018-05-29 Academia Sinica Compositions and methods for treatment and detection of cancers
WO2015112909A1 (fr) 2014-01-24 2015-07-30 Genentech, Inc. Procédés d'utilisation d'anticorps anti-steap1 et immunoconjugués
WO2015120075A2 (fr) 2014-02-04 2015-08-13 Genentech, Inc. Mutant smoothened et méthodes d'utilisation de celui-ci
EP3718563A1 (fr) 2014-02-08 2020-10-07 F. Hoffmann-La Roche AG Procédés de traitement de la maladie d'alzheimer
TW202239429A (zh) 2014-02-08 2022-10-16 美商建南德克公司 治療阿茲海默症之方法
AU2015217271B2 (en) 2014-02-12 2018-10-25 Genentech, Inc. Anti-Jagged1 antibodies and methods of use
BR112016018980A2 (pt) 2014-02-21 2017-10-10 Genentech Inc método de tratamento de um distúrbio, anticorpo multiespecífico, ácido nucleico isolado, célula hospedeira, métodos de produzir um anticorpo, de produção de uma metade de anticorpo ou de um anticorpo multiespecífico e de produção de um anticorpo multiespecífico, imunoconjugado e formulação farmacêutica
JP6825909B2 (ja) 2014-02-28 2021-02-03 アラコス インコーポレイテッド シグレック−８関連疾患を処置するための方法および組成物
MA39746A (fr) 2014-03-14 2021-04-28 Hoffmann La Roche Compositions de sécrétion de polypeptides hétérologues et procédés associés
WO2015140591A1 (fr) 2014-03-21 2015-09-24 Nordlandssykehuset Hf Anticorps anti-cd14 et leurs utilisations
BR112016021383A2 (pt) 2014-03-24 2017-10-03 Genentech Inc Método para identificar um paciente com câncer que é susceptível ou menos susceptível a responder ao tratamento com um antagonista de cmet, método para identificar um paciente apresentando câncer previamente tratado, método para determinar a expressão do biomarcador hgf, antagonista anti-c-met e seu uso, kit de diagnóstico e seu método de preparo
TWI687428B (zh) 2014-03-27 2020-03-11 中央研究院 反應性標記化合物及其用途
EP3632934A1 (fr) 2014-03-31 2020-04-08 F. Hoffmann-La Roche AG Anticorps anti-ox40 et procédés d'utilisation
WO2015153514A1 (fr) 2014-03-31 2015-10-08 Genentech, Inc. Thérapie combinatoires comprenant des agents anti-angiogenèse et des agonistes se liant à ox40
US10160812B2 (en) 2014-04-11 2018-12-25 Medimmune, Llc Bispecific HER2 antibodies
WO2015164615A1 (fr) 2014-04-24 2015-10-29 University Of Oslo Anticorps anti-gluten et leurs utilisations
MX2016015162A (es) 2014-05-22 2017-03-03 Genentech Inc Anticuerpos anti - gpc3 e inmunoconjugados.
CN106661622B (zh) 2014-05-23 2020-08-21 豪夫迈·罗氏有限公司 Mit生物标志物和使用它们的方法
AU2015267045B2 (en) 2014-05-27 2021-02-25 Academia Sinica Anti-HER2 glycoantibodies and uses thereof
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
EP3149161B1 (fr) 2014-05-27 2021-07-28 Academia Sinica Fucosidase issue de bacteroïdes et ses procédés d'utilisation
CN106573971A (zh) 2014-05-27 2017-04-19 中央研究院 抗cd20醣抗体及其用途
TWI732738B (zh) 2014-05-28 2021-07-11 中央研究院 抗TNF-α醣抗體及其用途
PT3148581T (pt) 2014-05-30 2020-01-06 Henlix Biotech Co Ltd Anticorpos antirrecetor do fator de crescimento epidérmico (egfr)
JP2017526618A (ja) 2014-06-11 2017-09-14 ジェネンテック， インコーポレイテッド 抗ＬｇＲ５抗体及びその使用
JP2017517552A (ja) 2014-06-13 2017-06-29 ジェネンテック， インコーポレイテッド 抗癌剤耐性の治療及び防止方法
KR20170026362A (ko) 2014-06-26 2017-03-08 에프. 호프만-라 로슈 아게 항-ｂｒｄｕ 항체 및 사용 방법
EP3166627A1 (fr) 2014-07-11 2017-05-17 Genentech, Inc. Inhibition de la voie de signalisation notch
EP3166974A1 (fr) 2014-07-11 2017-05-17 Genentech, Inc. Anticorps anti-pd-l1 et leurs utilisations
PE20170263A1 (es) * 2014-08-04 2017-03-30 Hoffmann La Roche Moleculas biespecificas de union a antigeno activadoras de celulas t
TWI751102B (zh) 2014-08-28 2022-01-01 美商奇諾治療有限公司 對ｃｄ１９具專一性之抗體及嵌合抗原受體
AU2015308818B2 (en) 2014-08-28 2021-02-25 Bioatla Llc Conditionally active chimeric antigen receptors for modified T-cells
WO2016040369A2 (fr) 2014-09-08 2016-03-17 Academia Sinica Activation des cellules inkt humaines par des glycolipides
JP2017528468A (ja) * 2014-09-10 2017-09-28 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ガラクトース操作型免疫グロブリン１抗体
US9751946B2 (en) 2014-09-12 2017-09-05 Genentech, Inc. Anti-CLL-1 antibodies and immunoconjugates
EP3191518B1 (fr) 2014-09-12 2020-01-15 Genentech, Inc. Anticorps anti-b7-h4 et immunoconjugués
EA201790545A1 (ru) 2014-09-12 2017-07-31 Дженентек, Инк. Антитела и иммуноконъюгаты против her2
BR112017004393A2 (pt) 2014-09-15 2018-02-27 Genentech Inc formulações de anticorpo
JP6730261B2 (ja) 2014-09-17 2020-07-29 ジェネンテック， インコーポレイテッド 抗ｈｅｒ２抗体を含む免疫複合体
PL3262071T3 (pl) 2014-09-23 2020-08-10 F. Hoffmann-La Roche Ag Sposób stosowania immunokoniugatów anty-CD79b
WO2016061389A2 (fr) 2014-10-16 2016-04-21 Genentech, Inc. Anticorps anti-alpha-synucléine et leurs méthodes d'utilisation
US10870704B2 (en) 2014-10-23 2020-12-22 Kira Biotech Pty Limited CD83 binding proteins and uses thereof
EP3223865A4 (fr) 2014-10-31 2018-10-03 Jounce Therapeutics, Inc. Méthodes de traitement d'états pathologiques avec des anticorps qui se lient à b7-h4
CA2966523A1 (fr) 2014-11-03 2016-05-12 Genentech, Inc. Tests de detection de sous-ensembles immunitaires de cellules t et leurs procedes d'utilisation
CN114381521A (zh) 2014-11-03 2022-04-22 豪夫迈·罗氏有限公司 用于ox40激动剂治疗的功效预测和评估的方法和生物标志物
CA2961439A1 (fr) 2014-11-05 2016-05-12 Genentech, Inc. Anticorps anti-fgfr2/3 et procedes d'utilisation de ceux-ci
CA2960797A1 (fr) 2014-11-06 2016-05-12 F. Hoffmann-La Roche Ag Variants du fragment fc caracterises par une liaison fcrn modifiee et leurs procedes d'utilisation
RU2017119428A (ru) 2014-11-06 2018-12-06 Дженентек, Инк. Комбинированная терапия, включающая применение агонистов, связывающихся с ох40, и ингибиторов tigit
AR102522A1 (es) 2014-11-06 2017-03-08 Hoffmann La Roche Variantes de región fc con propiedades modificadas de unión a fcrn y proteína a
CR20170240A (es) 2014-11-10 2018-04-03 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos
EP3552488A1 (fr) 2014-11-10 2019-10-16 F. Hoffmann-La Roche AG Modèle animal pour une néphropathie et agents pour la traiter
EP3224275B1 (fr) 2014-11-14 2020-03-04 F.Hoffmann-La Roche Ag Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
EP3218397B8 (fr) 2014-11-14 2021-04-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps neutralisants contre ebola glycoprotein et leur utilisation
WO2016081384A1 (fr) 2014-11-17 2016-05-26 Genentech, Inc. Polythérapie comprenant des agonistes se liant à ox40 et des antagonistes se liant à l'axe pd-1
US10508151B2 (en) 2014-11-19 2019-12-17 Genentech, Inc. Anti-transferrin receptor antibodies and methods of use
WO2016081639A1 (fr) 2014-11-19 2016-05-26 Genentech, Inc. Anticorps contre bace1 et utilisation de ceux-ci pour l'immunothérapie contre les maladies neurales
US11008403B2 (en) 2014-11-19 2021-05-18 Genentech, Inc. Anti-transferrin receptor / anti-BACE1 multispecific antibodies and methods of use
BR112017010324A2 (pt) 2014-11-20 2018-05-15 F. Hoffmann-La Roche Ag método para tratar ou retardar a progressão de um câncer em um indivíduo, moléculas, métodos para aumentar a função imune em um indivíduo e para selecionar um paciente para tratamento, kits, composição farmacêutica e usos de uma combinação de uma molécula
EP3227332B1 (fr) 2014-12-03 2019-11-06 F.Hoffmann-La Roche Ag Anticorps multi-spécifiques
US9975949B2 (en) 2014-12-05 2018-05-22 Genentech, Inc. Anti-CD79b antibodies and methods of use
RU2017120039A (ru) 2014-12-10 2019-01-10 Дженентек, Инк. Антитела к рецепторам гематоэнцефалического барьера и способы их применения
RU2746356C2 (ru) 2014-12-19 2021-04-12 Чугаи Сейяку Кабусики Кайся Антитела к с5 и способы их применения
WO2016111947A2 (fr) 2015-01-05 2016-07-14 Jounce Therapeutics, Inc. Anticorps inhibiteurs d'interactions de tim-3:lilrb2 et leurs utilisations
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US20160208018A1 (en) 2015-01-16 2016-07-21 Juno Therapeutics, Inc. Antibodies and chimeric antigen receptors specific for ror1
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
WO2016117346A1 (fr) 2015-01-22 2016-07-28 Chugai Seiyaku Kabushiki Kaisha Combinaison de deux anticorps anti-c5 ou plus et ses procédés d'utilisation
EP3248005B1 (fr) 2015-01-24 2020-12-09 Academia Sinica Nouveaux composés conjugués de glycane et leurs méthodes d'utilisation
US10330683B2 (en) 2015-02-04 2019-06-25 Genentech, Inc. Mutant smoothened and methods of using the same
KR20170110129A (ko) 2015-02-05 2017-10-10 추가이 세이야쿠 가부시키가이샤 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용
US10301377B2 (en) 2015-02-24 2019-05-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Middle east respiratory syndrome coronavirus immunogens, antibodies, and their use
MX2017011486A (es) 2015-03-16 2018-06-15 Genentech Inc Métodos de detección y cuantificación de il-13 y sus usos en el diagnóstico y tratamiento de enfermedades asociadas a th2.
WO2016146833A1 (fr) 2015-03-19 2016-09-22 F. Hoffmann-La Roche Ag Biomarqueurs de résistance à la nad(+)-diphtamide adp-ribosyltransférase
HUE049081T2 (hu) 2015-03-20 2020-09-28 The United States Of America As GP120 elleni neutralizáló antitestek és alkalmazásuk
LT3274370T (lt) 2015-03-23 2020-02-10 Bayer Pharma Aktiengesellschaft Antikūnai prieš ceacam6 ir jų panaudojimas
SI3273992T1 (sl) 2015-03-23 2020-09-30 Jounce Therapeutics, Inc. Protitelesa proti ICOS
JP6903587B2 (ja) 2015-04-03 2021-07-14 ユーリカ セラピューティックス， インコーポレイテッド Ａｆｐペプチド／ｍｈｃ複合体を標的化する構築物およびその使用
JP7044553B2 (ja) 2015-04-24 2022-03-30 ジェネンテック， インコーポレイテッド 結合ポリペプチドを含む細菌を特定する方法
CN107708986B (zh) * 2015-04-30 2019-12-13 富士胶片株式会社 装饰片
JP2018520642A (ja) 2015-05-01 2018-08-02 ジェネンテック， インコーポレイテッド マスク抗ｃｄ３抗体及びその使用方法
WO2016179194A1 (fr) 2015-05-04 2016-11-10 Jounce Therapeutics, Inc. Lilra3 et son procédé d'utilisation
EP4238994A3 (fr) * 2015-05-11 2024-02-07 F. Hoffmann-La Roche AG Compositions et méthodes de traitement de la néphropathie lupique
ES2835866T3 (es) 2015-05-12 2021-06-23 Hoffmann La Roche Procedimientos terapéuticos y de diagnóstico para el cáncer
EP3302563A1 (fr) 2015-05-29 2018-04-11 H. Hoffnabb-La Roche Ag Anticorps contre la glycoprotéine du virus ebola humanisés et procédés d'utilisation
KR20180012753A (ko) 2015-05-29 2018-02-06 제넨테크, 인크. 암에 대한 치료 및 진단 방법
CN107810012A (zh) 2015-06-02 2018-03-16 豪夫迈·罗氏有限公司 使用抗il‑34抗体治疗神经疾病的组合物和方法
WO2016196975A1 (fr) 2015-06-03 2016-12-08 The United States Of America, As Represented By The Secretary Department Of Health & Human Services Anticorps neutralisants dirigés contre la protéine d'enveloppe (env) du vih-1 et leur utilisation
AU2016272045B2 (en) 2015-06-04 2018-04-19 Ospedale San Raffaele Srl Inhibitor of IGFBP3/TMEM219 axis and diabetes
KR102141446B1 (ko) 2015-06-04 2020-08-06 오스페달레 산 라파엘 에스.알.엘. Ｉｇｆｂｐ3 및 이의 용도
CN107849124B (zh) 2015-06-05 2021-09-24 基因泰克公司 抗tau抗体及使用方法
CA2988420A1 (fr) 2015-06-08 2016-12-15 Genentech, Inc. Methodes destinees a traiter le cancer a l'aide d'anticorps anti-ox40 et d'antagonistes se liant a l'axe pd-1
EP3303399A1 (fr) 2015-06-08 2018-04-11 H. Hoffnabb-La Roche Ag Méthodes de traitement du cancer au moyen d'anticorps anti-ox40
JP2018524295A (ja) 2015-06-15 2018-08-30 ジェネンテック， インコーポレイテッド 抗体及び免疫複合体
WO2016204966A1 (fr) 2015-06-16 2016-12-22 Genentech, Inc. Anticorps anti-cd3 et leurs méthodes d'utilisation
CN107847568B (zh) 2015-06-16 2022-12-20 豪夫迈·罗氏有限公司 抗cll-1抗体和使用方法
TWI731861B (zh) 2015-06-16 2021-07-01 美商建南德克公司 FcRH5之人源化及親和力成熟抗體及使用方法
JP2018524312A (ja) 2015-06-17 2018-08-30 ジェネンテック， インコーポレイテッド 抗ｈｅｒ２抗体及び使用方法
JP6846362B2 (ja) 2015-06-17 2021-03-24 アラコス インコーポレイテッド 線維性疾患を処置するための方法および組成物
MX2017016353A (es) 2015-06-17 2018-05-02 Genentech Inc Metodos para tratar canceres de mama metastasicos o localmente avanzados con antagonistas de union al eje de pd-1 y taxanos.
EP3313442B1 (fr) * 2015-06-24 2019-10-16 H. Hoffnabb-La Roche Ag Anticorps contre le csf-1r humain permettant d'induire une lymphocytose dans les lymphomes ou les leucémies
DK3313879T3 (da) 2015-06-24 2022-03-14 Hoffmann La Roche Anti-transferrinreceptor-antistoffer med tilpasset affinitet
EP3108897A1 (fr) 2015-06-24 2016-12-28 F. Hoffmann-La Roche AG Anticorps contre le csf-1r humain permettant d'induire une lymphocytose dans les lymphomes ou les leucémies
CN115505042A (zh) 2015-06-26 2022-12-23 赛诺菲生物技术公司 单克隆抗il-1racp抗体
JP2018520153A (ja) 2015-06-29 2018-07-26 ジェネンテック， インコーポレイテッド 臓器移植における使用のためのｉｉ型抗ｃｄ２０抗体
ES2898065T3 (es) 2015-06-29 2022-03-03 Ventana Med Syst Inc Materiales y procedimientos para realizar ensayos histoquímicos para proepirregulina y anfirregulina humanas
CN105384825B (zh) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 一种基于单域抗体的双特异性嵌合抗原受体及其应用
EP3341415B1 (fr) 2015-08-28 2021-03-24 H. Hoffnabb-La Roche Ag Anticorps anti-hypusine et leurs utilisations
CA2999369C (fr) 2015-09-22 2023-11-07 Spring Bioscience Corporation Anticorps anti-ox40 et leurs utilisations diagnostiques
WO2017053807A2 (fr) 2015-09-23 2017-03-30 Genentech, Inc. Variants optimisés d'anticorps anti-vegf
WO2017053906A1 (fr) 2015-09-24 2017-03-30 Abvitro Llc Compositions d'anticorps anti-vih et méthodes d'utilisation
JP2018535655A (ja) 2015-09-29 2018-12-06 アムジエン・インコーポレーテツド Ａｓｇｒ阻害剤
AR106188A1 (es) 2015-10-01 2017-12-20 Hoffmann La Roche Anticuerpos anti-cd19 humano humanizados y métodos de utilización
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
CN114014936A (zh) 2015-10-02 2022-02-08 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
CN107849137B (zh) 2015-10-02 2021-11-26 豪夫迈·罗氏有限公司 双特异性抗ceaxcd3 t细胞活化性抗原结合分子
EP3150636A1 (fr) 2015-10-02 2017-04-05 F. Hoffmann-La Roche AG Anticorps multispécifiques tétravalents
KR102146319B1 (ko) 2015-10-02 2020-08-25 에프. 호프만-라 로슈 아게 Pd1 및 tim3에 특이적인 이중특이성 항체
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
BR112018002570A2 (pt) 2015-10-02 2018-10-16 Hoffmann La Roche molécula de ligação ao antígeno biespecífica, anticorpo biespecífico, polinucleotídeos, anticorpo que se liga especificamente ao ox40, composição farmacêutica e método para inibir o crescimento de células tumorais em um indivíduo
AU2016334623A1 (en) 2015-10-07 2018-02-15 F. Hoffmann-La Roche Ag Bispecific antibodies with tetravalency for a costimulatory TNF receptor
CA2997809A1 (fr) 2015-10-07 2017-04-13 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps specifiques d'il-7r-alpha pour le traitement la leucemie lymphoblastique aigue
US10604577B2 (en) 2015-10-22 2020-03-31 Allakos Inc. Methods and compositions for treating systemic mastocytosis
US10968277B2 (en) 2015-10-22 2021-04-06 Jounce Therapeutics, Inc. Gene signatures for determining ICOS expression
EP3184547A1 (fr) 2015-10-29 2017-06-28 F. Hoffmann-La Roche AG Anticorps anti-tpbg et procédés d'utilisation
CN114891102A (zh) 2015-10-29 2022-08-12 豪夫迈·罗氏有限公司 抗变体Fc区抗体及使用方法
EP3368074A2 (fr) 2015-10-30 2018-09-05 Hoffmann-La Roche AG Anticorps et conjugués anti-facteur d
HUE054093T2 (hu) 2015-10-30 2021-08-30 Hoffmann La Roche Anti-HtrA1 antitestek és azok alkalmazási eljárásai
WO2017079479A1 (fr) 2015-11-03 2017-05-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Anticorps neutralisants dirigés contre la protéine gp41 du vih-1 et leur utilisation
JP6998869B2 (ja) 2015-11-08 2022-02-04 ジェネンテック， インコーポレイテッド 多重特異性抗体のスクリーニング方法
RU2021107536A (ru) 2015-11-23 2021-07-02 Файв Прайм Терапьютикс, Инк. Ингибиторы fgfr2 отдельно или в комбинации с иммуностимулирующими агентами в лечении рака
JP7325186B2 (ja) * 2015-12-09 2023-08-14 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 抗薬物抗体の形成を減少させるためのｉｉ型抗ｃｄ２０抗体
EP3178848A1 (fr) 2015-12-09 2017-06-14 F. Hoffmann-La Roche AG Anticorps de type ii contre cd20 pour la reduction de la formation des anticorps contre des médicaments
PL3390442T3 (pl) 2015-12-18 2024-03-18 Chugai Seiyaku Kabushiki Kaisha Przeciwciała anty-c5 i sposoby ich stosowania
MX2018008347A (es) 2016-01-08 2018-12-06 Hoffmann La Roche Metodos de tratamiento de canceres positivos para ace utilizando antagonistas de union a eje pd-1 y anticuerpos biespecificos anti-ace/anti-cd3.
WO2017127764A1 (fr) 2016-01-20 2017-07-27 Genentech, Inc. Traitements à haute dose pour la maladie d'alzheimer
CA3019952A1 (fr) 2016-02-04 2017-08-10 Curis, Inc. Mutant smoothened et methodes d'utilisation dudit mutant
CN109196121B (zh) 2016-02-29 2022-01-04 基因泰克公司 用于癌症的治疗和诊断方法
WO2017148880A1 (fr) 2016-03-01 2017-09-08 F. Hoffmann-La Roche Ag Variantes de l'obinutuzumab dont l'induction de l'apoptose est modifiée
TW201808978A (zh) 2016-03-08 2018-03-16 中央研究院 N-聚醣及其陣列之模組化合成方法
TW202248213A (zh) 2016-03-15 2022-12-16 日商中外製藥股份有限公司 使用pd-1軸結合拮抗劑和抗gpc3抗體治療癌症的方法
FI3433280T3 (fi) 2016-03-22 2023-06-06 Hoffmann La Roche Proteaasin aktivoimia t-solubispesifisiä molekyylejä
JP6943872B2 (ja) 2016-03-25 2021-10-06 ジェネンテック， インコーポレイテッド 多重全抗体及び抗体複合体化薬物定量化アッセイ
TWI815793B (zh) 2016-03-31 2023-09-21 美商恩格姆生物製藥公司 結合蛋白質及其使用方法
WO2017180864A1 (fr) 2016-04-14 2017-10-19 Genentech, Inc. Anticorps anti-rspo3 et méthodes d'utilisation de ceux-ci
JP2019515670A (ja) 2016-04-15 2019-06-13 ジェネンテック， インコーポレイテッド がんをモニタリングし治療するための方法
ES2850428T3 (es) 2016-04-15 2021-08-30 Hoffmann La Roche Procedimientos de monitorización y tratamiento del cáncer
CA3021086C (fr) 2016-04-15 2023-10-17 Bioatla, Llc Anticorps anti-axl, fragments d'anticorps et leurs immunoconjugues et utilisations associees
UA123323C2 (uk) 2016-05-02 2021-03-17 Ф. Хоффманн-Ля Рош Аг Димерний злитий поліпептид
WO2017192589A1 (fr) 2016-05-02 2017-11-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps neutralisants dirigés contre la grippe ha, leur utilisation et leur identification
EP3241845A1 (fr) 2016-05-06 2017-11-08 MAB Discovery GmbH Anticorps anti-il-1r3 humanisés
WO2017194442A1 (fr) 2016-05-11 2017-11-16 F. Hoffmann-La Roche Ag Molécules de liaison à un antigène comprenant un ligand trimérique de la famille du tnf et un fragment de liaison à la ténascine
EP3243836A1 (fr) 2016-05-11 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison à un antigène contenant un trimère d'un ligand de la famille du tnf fusionné en terminaison c
EP3455252B1 (fr) 2016-05-11 2022-02-23 F. Hoffmann-La Roche AG Anticorps anti-ténascine modifiés et procédés d'utilisation
EP3243832A1 (fr) 2016-05-13 2017-11-15 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf et un fragment de liaison pd1
SI3455261T1 (sl) 2016-05-13 2023-01-31 Bioatla, Inc. Protitelesa proti ROR2, fragmenti protitelesa, njihovi imunokonjugati in uporabe le-teh
WO2017201449A1 (fr) 2016-05-20 2017-11-23 Genentech, Inc. Conjugués anticorps-protac et procédés d'utilisation
JP7022080B2 (ja) 2016-05-27 2022-02-17 ジェネンテック， インコーポレイテッド 部位特異的抗体－薬物複合体の特徴付けのための生化学分析的方法
EP3252078A1 (fr) 2016-06-02 2017-12-06 F. Hoffmann-La Roche AG Anticorps de type ii contre cd20 et anticorps bispecifique contre cd20/cd3 pour traitement de cancer
TW201902512A (zh) 2016-06-02 2019-01-16 瑞士商赫孚孟拉羅股份公司 治療方法
EP3257866A1 (fr) 2016-06-17 2017-12-20 Academisch Medisch Centrum Anticorps anti-tnf modifiés et leur utilisation dans le traitement de la maladie intestinale inflammatoire
CN109563160B (zh) 2016-06-24 2023-02-28 豪夫迈·罗氏有限公司 抗聚泛素多特异性抗体
BR112018077375A2 (pt) * 2016-06-30 2019-10-01 F. Hoffmann-La Roche Ag kits, moléculas de anticorpo biespecífico trivalente, composição farmacêutica, vetor de expressão, célula hospedeira e método para a produção de uma molécula de anticorpo biespecífico trivalente
WO2018007314A1 (fr) 2016-07-04 2018-01-11 F. Hoffmann-La Roche Ag Nouveau format d'anticorps
WO2018014260A1 (fr) 2016-07-20 2018-01-25 Nanjing Legend Biotech Co., Ltd. Protéines de liaison antigènes multi-spécifiques et leurs procédés d'utilisation
CN110088133B (zh) 2016-07-29 2023-12-08 朱诺治疗学股份有限公司 抗独特型抗体及相关方法
RU2019104730A (ru) 2016-07-29 2020-08-28 Чугаи Сейяку Кабусики Кайся Биспецифическое антитело, обладающее повышенной активностью, альтернативной функции кофактора fviii
CN116251182A (zh) 2016-08-05 2023-06-13 中外制药株式会社 用于预防或治疗il-8相关疾病的组合物
JP7250674B2 (ja) 2016-08-08 2023-04-03 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト がんの治療及び診断方法
JP7213549B2 (ja) 2016-08-22 2023-01-27 シーエイチオー ファーマ インコーポレイテッド 抗体、結合性断片、および使用の方法
WO2018045379A1 (fr) 2016-09-02 2018-03-08 Dana-Farber Cancer Institute, Inc. Composition et méthodes de traitement des déreglements des lymphocytes b
EP3510046A4 (fr) 2016-09-07 2020-05-06 The Regents of the University of California Anticorps contre des épitopes spécifiques à l'oxydation
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
CN109689682B (zh) 2016-09-19 2022-11-29 豪夫迈·罗氏有限公司 基于补体因子的亲和层析
KR102557643B1 (ko) 2016-09-23 2023-07-20 제넨테크, 인크. 아토피성 피부염을 치료하기 위한 il-13 길항제의 용도
EP3519437B1 (fr) 2016-09-30 2021-09-08 F. Hoffmann-La Roche AG Anticorps bispécifiques dirigés contre p95her2
CN110139873A (zh) 2016-10-03 2019-08-16 朱诺治疗学股份有限公司 Hpv特异性结合分子
CN110139674B (zh) 2016-10-05 2023-05-16 豪夫迈·罗氏有限公司 制备抗体药物缀合物的方法
AU2017339517B2 (en) 2016-10-06 2024-03-14 Foundation Medicine, Inc. Therapeutic and diagnostic methods for cancer
WO2018068201A1 (fr) 2016-10-11 2018-04-19 Nanjing Legend Biotech Co., Ltd. Anticorps à domaine unique et ses variants contre ctla-4
EP3532091A2 (fr) 2016-10-29 2019-09-04 H. Hoffnabb-La Roche Ag Anticorps anti-mic et méthodes d'utilisation
AU2017355401A1 (en) 2016-11-02 2019-05-02 Jounce Therapeutics, Inc. Antibodies to PD-1 and uses thereof
AU2017361081A1 (en) 2016-11-15 2019-05-23 Genentech, Inc. Dosing for treatment with anti-CD20/anti-CD3 bispecific antibodies
JOP20190100A1 (ar) 2016-11-19 2019-05-01 Potenza Therapeutics Inc بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها
AU2017361887B2 (en) 2016-11-21 2019-08-15 Cureab Gmbh Anti-GP73 antibodies and immunoconjugates
CR20230163A (es) 2016-12-07 2023-07-06 Genentech Inc ANTICUERPOS ANTITAU Y MÉTODOS DE USO (Divisional 2019-0271)
AU2017373884A1 (en) 2016-12-07 2019-05-30 Ac Immune Sa Anti-tau antibodies and methods of their use
EP3551663A1 (fr) 2016-12-12 2019-10-16 H. Hoffnabb-La Roche Ag Procédés de traitement du cancer à l'aide d'anticorps anti-pd-l1 et d'anti-androgènes
CN110087682B (zh) 2016-12-19 2023-12-15 豪夫迈·罗氏有限公司 用靶向性4-1bb(cd137)激动剂的组合疗法
EP3559034B1 (fr) 2016-12-20 2020-12-02 H. Hoffnabb-La Roche Ag Thérapie de combinaison d'anticorps bispécifiques anti-cd20/anti-cd3 et agonistes 4 - 1bb (cd137)
JOP20190134A1 (ar) 2016-12-23 2019-06-02 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها
BR112019013189A2 (pt) 2017-01-03 2019-12-10 Hoffmann La Roche moléculas de ligação ao antígeno biespecífica, polinucleotídeo, célula hospedeira, método de produção da molécula de ligação ao antígeno biespecífica, composição farmacêutica, uso, métodos para inibir o crescimento de células tumorais em um indivíduo e para tratar o câncer ou uma doença infecciosa
TW201825515A (zh) 2017-01-04 2018-07-16 美商伊繆諾金公司 Ｍｅｔ抗體以及其免疫結合物及用途
TW201831517A (zh) 2017-01-12 2018-09-01 美商優瑞科生物技術公司 靶向組織蛋白h3肽/mhc複合體之構築體及其用途
US11021535B2 (en) 2017-02-10 2021-06-01 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to plasmodium falciparum circumsporozoite protein and their use
AR110873A1 (es) 2017-02-10 2019-05-08 Genentech Inc Anticuerpos contra triptasa, composiciones de estos y usos de estos
TW201837467A (zh) 2017-03-01 2018-10-16 美商建南德克公司 用於癌症之診斷及治療方法
MX2019011141A (es) 2017-03-22 2019-11-05 Genentech Inc Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares.
TW202400231A (zh) 2017-03-28 2024-01-01 美商建南德克公司 治療神經退化性疾病之方法
CN110382542B (zh) 2017-03-29 2023-06-09 豪夫迈·罗氏有限公司 针对共刺激性tnf受体的双特异性抗原结合分子
CN110573528B (zh) 2017-03-29 2023-06-09 豪夫迈·罗氏有限公司 针对共刺激性tnf受体的双特异性抗原结合分子
JOP20190203A1 (ar) 2017-03-30 2019-09-03 Potenza Therapeutics Inc بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها
BR112019017753A2 (pt) 2017-04-04 2020-04-07 Hoffmann La Roche molécula biespecífica, polinucleotídeo, vetor, célula, métodos para a produção de uma molécula e para o tratamento de um indivíduo, composição e uso da molécula biespecífica
KR102346336B1 (ko) 2017-04-05 2022-01-04 에프. 호프만-라 로슈 아게 Pd1 및 lag3에 특이적으로 결합하는 이중특이적 항체
EP3619235A1 (fr) 2017-04-11 2020-03-11 Inhibrx, Inc. Constructions polypeptidiques multispécifiques comprenant une liaison cd3 contrainte et leurs méthodes d'utilisation
MX2019012192A (es) 2017-04-14 2020-01-21 Genentech Inc Métodos de diagnóstico y terapéuticos para el cáncer.
JP2020517638A (ja) 2017-04-20 2020-06-18 エータイアー ファーマ， インコーポレイテッド 肺の炎症を治療するための組成物および方法
JP7248588B2 (ja) 2017-04-21 2023-03-29 ジェネンテック， インコーポレイテッド 疾患の治療のためのｋｌｋ５アンタゴニストの使用
WO2018200586A1 (fr) 2017-04-26 2018-11-01 Eureka Therapeutics, Inc. Constructions reconnaissant spécifiquement le glypicane 3 et utilisations de ces dernieres
US20220135670A1 (en) 2017-04-27 2022-05-05 Tesaro, Inc. Antibody agents directed against lymphocyte activation gene-3 (lag-3) and uses thereof
MX2019013137A (es) 2017-05-05 2020-07-14 Allakos Inc Metodos y composiciones para tratar enfermedades oculares alergicas.
EP3401332A1 (fr) 2017-05-08 2018-11-14 MAB Discovery GmbH Anticorps anti-il-1r3 destinés à être utilisés dans des conditions inflammatoires
SG10202112636SA (en) 2017-05-16 2021-12-30 Five Prime Therapeutics Inc Anti-fgfr2 antibodies in combination with chemotherapy agents in cancer treatment
WO2019011918A1 (fr) 2017-07-10 2019-01-17 International - Drug - Development - Biotech Traitement de malignités de lymphocytes b à l'aide d'anticorps anti-cd19 pro-apoptotiques afucosylés en combinaison avec des anticorps anti-cd20 ou des agents chimiothérapeutiques
JP2020527351A (ja) 2017-07-21 2020-09-10 ジェネンテック， インコーポレイテッド がんの治療法及び診断法
EP3658589B1 (fr) 2017-07-26 2023-09-27 Forty Seven, Inc. Anticorps anti-sirp-alpha et méthodes associées
WO2019020606A1 (fr) 2017-07-26 2019-01-31 F. Hoffmann-La Roche Ag Polythérapie avec un inhibiteur bet, un inhibiteur bcl-2 et un anticorps anti-cd20
JP7418322B2 (ja) 2017-08-08 2024-01-19 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｄｌｂｃｌ患者サブグループのオビヌツズマブ治療
CN107881160A (zh) * 2017-08-11 2018-04-06 百奥泰生物科技(广州)有限公司 一种由基因组被编辑的cho宿主细胞产生的具有独特糖谱的重组抗体及其制备方法
CN111511762A (zh) 2017-08-21 2020-08-07 天演药业公司 抗cd137分子及其用途
EP3456738A1 (fr) * 2017-09-19 2019-03-20 Tillotts Pharma Ag Variantes d'anticorps
EP3684413A1 (fr) 2017-09-20 2020-07-29 Chugai Seiyaku Kabushiki Kaisha Posologie pour polythérapie utilisant des antagonistes de liaison d'axe pd-1 et un agent de ciblage gpc3
CA3080546A1 (fr) 2017-10-03 2019-04-11 Juno Therapeutics, Inc. Molecules de liaison specifique a l'hpv
CN111372950A (zh) 2017-10-12 2020-07-03 免疫苏醒公司 Vegfr-抗体轻链融合蛋白
EP3697818A2 (fr) 2017-10-19 2020-08-26 H. Hoffnabb-La Roche Ag Composition pharmaceutique
CA3079036A1 (fr) 2017-11-01 2019-05-09 F. Hoffmann-La Roche Ag Polytherapie avec des agonistes de ox40 cibles
CA3080904A1 (fr) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Anticorps et recepteurs antigeniques chimeriques specifiques de l'antigene de maturation des lymphocytes b
JP2021500902A (ja) 2017-11-01 2021-01-14 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 新規ｔｎｆファミリーリガンド三量体含有抗原結合分子
EP3703821A2 (fr) 2017-11-01 2020-09-09 F. Hoffmann-La Roche AG Anticorps 2 + 1 bispécifiques (contorsbodies)
JP2021502066A (ja) 2017-11-06 2021-01-28 ジェネンテック， インコーポレイテッド がんの診断及び療法
KR20200092328A (ko) 2017-12-01 2020-08-03 화이자 인코포레이티드 항-cxcr5 항체 및 그의 조성물 및 용도
MX2020006125A (es) 2017-12-14 2020-08-24 Hoffmann La Roche Uso de un anticuerpo biespecifico de cea cd3 y un antagonista de la union al eje de pd-1 en un regimen de dosificacion para tratar el cancer.
EP3724225A1 (fr) 2017-12-15 2020-10-21 Juno Therapeutics, Inc. Molécules de liaison à l'anti-cct5 et procédés d'utilisation associés
EP3502140A1 (fr) 2017-12-21 2019-06-26 F. Hoffmann-La Roche AG Thérapie de combinaison d'agonistes d'icos ciblés contre la tumeur avec des molécules bispécifiques à cellules t
EP4219559A3 (fr) 2017-12-22 2023-10-18 Jounce Therapeutics, Inc. Anticorps pour lilrb2
EP3728321A1 (fr) 2017-12-22 2020-10-28 F. Hoffmann-La Roche AG Utilisation d'agents de liaison à pilra pour le traitement d'une maladie
KR20200104886A (ko) 2017-12-28 2020-09-04 난징 레전드 바이오테크 씨오., 엘티디. Pd-l1에 대한 항체 및 변이체
KR20200104333A (ko) 2017-12-28 2020-09-03 난징 레전드 바이오테크 씨오., 엘티디. Tigit에 대한 단일-도메인 항체 및 이의 변이체
EP3724223A1 (fr) 2018-01-02 2020-10-21 The United States of America, as represented by The Secretary, Department of Health and Human Services Anticorps neutralisants dirigés contre la glycoprotéine du virus ebola et leur utilisation
EP3735422A1 (fr) 2018-01-05 2020-11-11 AC Immune SA Molécules de liaison de tdp-43 mal-repliées
EP3508499A1 (fr) 2018-01-08 2019-07-10 iOmx Therapeutics AG Anticorps ciblant et d'autres modulateurs d'un gène d'immunoglobuline associé à une résistance contre des réponses immunitaires antitumorales et leurs utilisations
US11713353B2 (en) 2018-01-15 2023-08-01 Nanjing Legend Biotech Co., Ltd. Single-domain antibodies and variants thereof against PD-1
EP3740505A1 (fr) 2018-01-16 2020-11-25 Lakepharma Inc. Anticorps bispécifique se liant à cd3 et à une autre cible
MA51676A (fr) 2018-01-26 2021-05-05 Hoffmann La Roche Protéines de fusion il-22 fc et procédés d'utilisation
PT3743088T (pt) 2018-01-26 2022-12-05 Hoffmann La Roche Composições il-22 fc e métodos de utilização
CN116041516A (zh) 2018-02-01 2023-05-02 信达生物制药(苏州)有限公司 全人源的抗b细胞成熟抗原(bcma)单链抗体及其应用
WO2019148445A1 (fr) 2018-02-02 2019-08-08 Adagene Inc. Anticorps activables dépendant de la précision/du contexte, et leurs procédés de fabrication et d'utilisation
AU2019218959A1 (en) 2018-02-08 2020-09-03 Genentech, Inc. Bispecific antigen-binding molecules and methods of use
SG11202007564VA (en) 2018-02-09 2020-09-29 Genentech Inc Therapeutic and diagnostic methods for mast cell-mediated inflammatory diseases
CN111757894A (zh) 2018-02-14 2020-10-09 Abba 疗法股份公司 抗人类pd-l2抗体
MX2020008502A (es) 2018-02-21 2020-09-25 Genentech Inc Dosis para el tratamiento con proteinas de fusion il-22 fc.
AU2019226034A1 (en) 2018-02-21 2020-10-15 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Neutralizing antibodies to HIV-1 Env and their use
WO2019165434A1 (fr) 2018-02-26 2019-08-29 Genentech, Inc. Dosage pour traitement avec des anticorps antagonistes anti-tigit et anti-pd-l1
WO2019175071A1 (fr) 2018-03-13 2019-09-19 F. Hoffmann-La Roche Ag Combinaison thérapeutique d'agonistes de 4-1 bb avec des anticorps anti-cd20
TW202003561A (zh) 2018-03-13 2020-01-16 瑞士商赫孚孟拉羅股份公司 使用靶向4-1bb (cd137)之促效劑的組合療法
BR112020014591A2 (pt) 2018-03-14 2020-12-01 Beijing Xuanyi Pharmasciences Co., Ltd. anticorpos anticlaudina 18.2
US20200040103A1 (en) 2018-03-14 2020-02-06 Genentech, Inc. Anti-klk5 antibodies and methods of use
CA3093729A1 (fr) 2018-03-15 2019-09-19 Chugai Seiyaku Kabushiki Kaisha Anticorps diriges contre le virus de la dengue presentant une reactivite croisee au virus zika et procedes d'utilisation
TW201945393A (zh) 2018-03-21 2019-12-01 美商戊瑞治療有限公司 在酸性pH結合至VISTA之抗體
EP3774917A4 (fr) 2018-03-30 2022-01-19 Nanjing Legend Biotech Co., Ltd. Anticorps à domaine unique contre lag-3 et leurs utilisations
TW202011029A (zh) 2018-04-04 2020-03-16 美商建南德克公司 偵測及定量fgf21之方法
CN112566698A (zh) 2018-04-05 2021-03-26 朱诺治疗学股份有限公司 T细胞受体和表达该t细胞受体的工程化细胞
US20190330366A1 (en) 2018-04-11 2019-10-31 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and related methods and uses
AR114284A1 (es) 2018-04-13 2020-08-12 Hoffmann La Roche Moléculas de unión a antígeno dirigidas a her2 que comprenden 4-1bbl
EP3560945A1 (fr) 2018-04-27 2019-10-30 F. Hoffmann-La Roche AG Procédés de purification de polypeptides utilisant des polysorbates
WO2019235426A1 (fr) 2018-06-04 2019-12-12 中外製薬株式会社 Molécule de liaison à un antigène présentant une demi-vie modifiée dans le cytoplasme
MA52951A (fr) 2018-06-22 2021-04-28 Genmab Holding B V Anticorps anti-cd37 et anticorps anti-cd20, compositions et méthodes d'utilisation de ceux-ci
WO2019246557A1 (fr) 2018-06-23 2019-12-26 Genentech, Inc. Méthodes de traitement du cancer du poumon à l'aide d'un antagoniste de liaison à l'axe pd-1, d'un agent de platine et d'un inhibiteur de la topoisomérase ii
EP3818082A1 (fr) 2018-07-04 2021-05-12 F. Hoffmann-La Roche AG Nouvelles molécules de liaison à l'antigène 4-1bb bispécifiques
PE20211604A1 (es) 2018-07-09 2021-08-23 Five Prime Therapeutics Inc Anticuerpos de union a ilt4
WO2020014306A1 (fr) 2018-07-10 2020-01-16 Immunogen, Inc. Anticorps anti-met, immunoconjugués et utilisations de ceux-ci
TW202028235A (zh) 2018-07-11 2020-08-01 美商戊瑞治療有限公司 於酸性ｐｈ結合至含免疫球蛋白ｖ域之t細胞活化抑制子（ｖｉｓｔａ）之抗體
CA3104147A1 (fr) 2018-07-18 2020-01-23 Genentech, Inc. Procedes de traitement du cancer du poumon par un antagoniste de liaison d'axe pd-1, un antimetabolite et un agent a base de platine
AU2019306628A1 (en) 2018-07-20 2021-02-11 Surface Oncology, Inc. Anti-CD112R compositions and methods
US20200048350A1 (en) 2018-07-24 2020-02-13 Inhibrx, Inc. Multispecific polypeptide constructs containing a constrained cd3 binding domain and a receptor binding region and methods of using the same
WO2020027330A1 (fr) 2018-08-03 2020-02-06 中外製薬株式会社 Molécule de liaison à l'antigène contenant deux domaines de liaison à l'antigène liés l'un à l'autre
CA3051549A1 (fr) 2018-08-09 2020-02-09 Regeneron Pharmaceuticals, Inc. Procedes d`evaluation de l`affinite de liaison d`une variante d`anticorps au recepteur fc neonatal
WO2020032230A1 (fr) 2018-08-10 2020-02-13 中外製薬株式会社 Molécule de liaison à l'antigène anti-cd137 et utilisation associée
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
AU2019342099A1 (en) 2018-09-19 2021-04-08 Genentech, Inc. Therapeutic and diagnostic methods for bladder cancer
EP4249917A3 (fr) 2018-09-21 2023-11-08 F. Hoffmann-La Roche AG Méthodes de diagnostic du cancer du sein triple négatif
JP2022502088A (ja) 2018-09-27 2022-01-11 エクシリオ デベロップメント， インコーポレイテッド マスクされたサイトカインポリペプチド
JP7221379B2 (ja) 2018-10-01 2023-02-13 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 抗ｆａｐクローン２１２を含む二重特異性抗原結合分子
EP3861025A1 (fr) 2018-10-01 2021-08-11 F. Hoffmann-La Roche AG Molécules bispécifiques de liaison à l'antigène ayant une liaison trivalent à cd40
EP3632929A1 (fr) 2018-10-02 2020-04-08 Ospedale San Raffaele S.r.l. Anticorps et leurs utilisations
US20220010020A1 (en) 2018-10-05 2022-01-13 Five Prime Therapeutics, Inc. Anti-FGFR2 Antibody Formulations
US11208485B2 (en) 2018-10-11 2021-12-28 Inhibrx, Inc. PD-1 single domain antibodies and therapeutic compositions thereof
WO2020081493A1 (fr) 2018-10-16 2020-04-23 Molecular Templates, Inc. Protéines de liaison pd-l1
MX2021004348A (es) 2018-10-18 2021-05-28 Genentech Inc Procedimientos de diagnóstico y terapéuticos para el cáncer de riñón sarcomatoide.
EP3873944A1 (fr) 2018-10-31 2021-09-08 Bayer Aktiengesellschaft Agents d'inversion pour la neutralisation de l'activité thérapeutique d'anticorps anti-fxia
EP3880714A4 (fr) 2018-11-16 2022-07-20 Memorial Sloan Kettering Cancer Center Anticorps dirigés contre la mucine-16 et leurs procédés d'utilisation
KR20210100656A (ko) 2018-12-05 2021-08-17 제넨테크, 인크. 암 면역요법을 위한 진단 방법 및 조성물
MX2021006573A (es) 2018-12-06 2021-07-15 Genentech Inc Tratamiento conjunto de linfoma difuso de linfocitos b grandes que comprende un inmunoconjugado anti-cd79b, un agente alquilante y un anticuerpo anti-cd20.
CN113227119A (zh) 2018-12-10 2021-08-06 基因泰克公司 用于与含Fc的蛋白质进行位点特异性缀合的光交联肽
US20220089694A1 (en) 2018-12-20 2022-03-24 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Ebola virus glycoprotein-specific monoclonal antibodies and uses thereof
EP3898667A2 (fr) 2018-12-20 2021-10-27 F. Hoffmann-La Roche AG Fc d'anticorps modifiés et méthodes d'utilisation
AR117728A1 (es) 2018-12-21 2021-08-25 Hoffmann La Roche Moléculas superagonistas de unión al antígeno cd28 con diana tumoral
MY198034A (en) 2018-12-21 2023-07-27 Hoffmann La Roche Tumor-targeted agonistic cd28 antigen binding molecules
EP3902833A2 (fr) 2018-12-26 2021-11-03 City of Hope Protéines de liaison anti-ctla4 masquées activables
CN113272327A (zh) 2018-12-30 2021-08-17 豪夫迈·罗氏有限公司 抗兔cd19抗体及其使用方法
AU2020208193A1 (en) 2019-01-14 2021-07-29 BioNTech SE Methods of treating cancer with a PD-1 axis binding antagonist and an RNA vaccine
CA3126778A1 (fr) 2019-01-17 2020-07-23 Bayer Aktiengesellschaft Procedes permettant de determiner si un sujet est apte a etre traite avec un agoniste de guanylyle cyclase soluble (sgc)
JPWO2020153467A1 (ja) 2019-01-24 2021-12-02 中外製薬株式会社 新規がん抗原及びそれらの抗原に対する抗体
PE20212198A1 (es) 2019-01-29 2021-11-16 Juno Therapeutics Inc Anticuerpos y receptores quimericos de antigenos especificos para receptor 1 huerfano tipo receptor tirosina-cinasa (ror1)
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
CN113710706A (zh) 2019-02-27 2021-11-26 豪夫迈·罗氏有限公司 用于抗tigit抗体和抗cd20抗体或抗cd38抗体治疗的给药
MX2021010565A (es) 2019-03-08 2021-10-13 Genentech Inc Metodos para detectar y cuantificar proteinas asociadas a la membrana en vesiculas extracelulares.
MA55296A (fr) 2019-03-14 2022-03-23 Hoffmann La Roche Traitement du cancer avec des anticorps bispécifiques de her2xcd3 en combinaison avec un mab anti-her2
CN113677403A (zh) 2019-04-12 2021-11-19 豪夫迈·罗氏有限公司 包含脂质运载蛋白突变蛋白的双特异性抗原结合分子
TW202106876A (zh) 2019-04-19 2021-02-16 日商中外製藥股份有限公司 辨識抗體改變部位之嵌合受體
CN114364703A (zh) 2019-04-19 2022-04-15 豪夫迈·罗氏有限公司 抗mertk抗体及它们的使用方法
AU2020270376A1 (en) 2019-05-03 2021-10-07 Genentech, Inc. Methods of treating cancer with an anti-PD-L1 antibody
WO2020227228A2 (fr) 2019-05-03 2020-11-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps neutralisants dirigés contre la protéine circumsporozoïte de plasmodium falciparum et leur utilisation
JP2022536602A (ja) 2019-05-14 2022-08-18 ジェネンテック， インコーポレイテッド 濾胞性リンパ腫を処置するための抗ｃｄ７９ｂ免疫複合体の使用方法
US20230085439A1 (en) 2019-05-21 2023-03-16 University Of Georgia Research Foundation, Inc. Antibodies that bind human metapneumovirus fusion protein and their use
SG11202112453TA (en) 2019-05-23 2021-12-30 Ac Immune Sa Anti-tdp-43 binding molecules and uses thereof
EP4023230A4 (fr) * 2019-06-05 2023-11-15 Chugai Seiyaku Kabushiki Kaisha Molécule de liaison à un site de clivage d'anticorps
TW202115124A (zh) 2019-06-26 2021-04-16 瑞士商赫孚孟拉羅股份公司 結合至cea之新穎抗原結合分子
WO2020260326A1 (fr) 2019-06-27 2020-12-30 F. Hoffmann-La Roche Ag Nouveaux anticorps anti-icos et molécules de liaison à un antigène ciblant les tumeurs les comprenant
MX2022000174A (es) 2019-07-02 2022-05-20 Us Health Anticuerpos monoclonales que se enlazan a egfrviii y sus usos.
AU2020311579A1 (en) 2019-07-05 2022-02-03 Iomx Therapeutics Ag Antibodies binding IgC2 of IGSF11 (VSIG3) and uses thereof
JPWO2021010326A1 (fr) 2019-07-12 2021-01-21
TWI780464B (zh) 2019-08-06 2022-10-11 香港商新旭生技股份有限公司 結合至病理性ｔａｕ種類之抗體及其用途
KR20220062304A (ko) 2019-09-12 2022-05-16 제넨테크, 인크. 루푸스 신장염을 치료하는 조성물과 방법
CA3149719A1 (fr) 2019-09-19 2021-03-25 Bristol-Myers Squibb Company Anticorps se liant a vista a un ph acide
KR20220066295A (ko) 2019-09-20 2022-05-24 제넨테크, 인크. 항트립타제 항체의 투약
CR20220127A (es) 2019-09-27 2022-05-27 Genentech Inc Administración de dosis para tratamiento con anticuerpos antagonistas anti-tigit y anti-pd-l1
JP7413519B2 (ja) 2019-10-18 2024-01-15 ジェネンテック， インコーポレイテッド びまん性大細胞型ｂ細胞リンパ腫を処置するための抗ｃｄ７９ｂ免疫抱合体の使用方法
US20220389103A1 (en) 2019-11-06 2022-12-08 Genentech, Inc. Diagnostic and therapeutic methods for treatment of hematologic cancers
JP2023501229A (ja) 2019-11-15 2023-01-18 エンテラ・エッセ・エッレ・エッレ Ｔｍｅｍ２１９抗体及びその治療的使用
EP3822288A1 (fr) 2019-11-18 2021-05-19 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Anticorps ciblant et autres modulateurs de l'antigène cd276 et leurs utilisations
WO2021099574A1 (fr) 2019-11-21 2021-05-27 Enthera S.R.L. Anticorps igfbp3 et leurs utilisations thérapeutiques
WO2021113780A1 (fr) 2019-12-06 2021-06-10 Juno Therapeutics, Inc. Anticorps anti-idiotypiques dirigés contre des domaines de liaison ciblant gprc5d et compositions et procédés associés
JP2023504740A (ja) 2019-12-06 2023-02-06 ジュノー セラピューティクス インコーポレイテッド Ｂｃｍａ標的結合ドメインに対する抗イディオタイプ抗体ならびに関連する組成物および方法
PE20221511A1 (es) 2019-12-13 2022-10-04 Genentech Inc Anticuerpos anti-ly6g6d y metodos de uso
CN113045655A (zh) 2019-12-27 2021-06-29 高诚生物医药(香港)有限公司 抗ox40抗体及其用途
US20230058982A1 (en) 2019-12-27 2023-02-23 Chugai Seiyaku Kabushiki Kaisha Anti-ctla-4 antibody and use thereof
CA3162009A1 (fr) 2020-01-09 2021-07-15 F. Hoffmann-La Roche Ag Nouvelles molecules de liaison a l'antigene contenant un trimere de 4-1bbl
CN110818795B (zh) 2020-01-10 2020-04-24 上海复宏汉霖生物技术股份有限公司 抗tigit抗体和使用方法
WO2021194481A1 (fr) 2020-03-24 2021-09-30 Genentech, Inc. Dosage pour le traitement avec des anticorps antagonistes anti-tigit et anti-pd-l1
WO2022050954A1 (fr) 2020-09-04 2022-03-10 Genentech, Inc. Dosage pour traitement avec anticorps antagonistes anti-tigit et anti-pd-l1
IL294879A (en) 2020-01-29 2022-09-01 Inhibrx Inc Monodomain antibodies of cd28 and their multivalent and multispecific constructs
CN115768800A (zh) 2020-01-31 2023-03-07 克利夫兰诊所基金会 抗苗勒管激素受体2抗体和使用方法
TW202142257A (zh) 2020-01-31 2021-11-16 美商建南德克公司 用ｐｄ－１軸結合拮抗劑及ｒｎａ疫苗誘導新抗原決定基特異性ｔ細胞之方法
TW202144395A (zh) 2020-02-12 2021-12-01 日商中外製藥股份有限公司 用於癌症之治療的抗cd137抗原結合分子
US11692038B2 (en) 2020-02-14 2023-07-04 Gilead Sciences, Inc. Antibodies that bind chemokine (C-C motif) receptor 8 (CCR8)
WO2021168292A1 (fr) 2020-02-20 2021-08-26 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux de virus d'epstein-barr et leurs utilisations
EP3868396A1 (fr) 2020-02-20 2021-08-25 Enthera S.R.L. Inhibiteurs et leurs utilisations
WO2021170067A1 (fr) 2020-02-28 2021-09-02 上海复宏汉霖生物技术股份有限公司 Construction anti-cd137 et son utilisation
CN115151573A (zh) 2020-02-28 2022-10-04 上海复宏汉霖生物技术股份有限公司 抗cd137构建体、多特异性抗体及其用途
WO2021183849A1 (fr) 2020-03-13 2021-09-16 Genentech, Inc. Anticorps anti-interleukine-33 et leurs utilisations
EP4121163A1 (fr) 2020-03-19 2023-01-25 Genentech, Inc. Anticorps anti-tgf-bêta sélectifs d'isoforme et procédés d'utilisation
JP2023518814A (ja) 2020-03-23 2023-05-08 ジェネンテック， インコーポレイテッド Ｃｏｖｉｄ－１９肺炎における、ｉｌ－６アンタゴニストに対する応答を予測するためのバイオマーカー
US20240025991A1 (en) 2020-03-23 2024-01-25 Genentech, Inc. Method for treating pneumonia, including covid-19 pneumonia, with an il6 antagonist
JP2023518812A (ja) 2020-03-23 2023-05-08 ジェネンテック， インコーポレイテッド Ｃｏｖｉｄ１９肺炎を治療するための、トシリズマブとレムデシビルとの組み合わせ
CA3169967A1 (fr) 2020-03-24 2021-09-30 Genentech, Inc. Agents de liaison a tie2 et leurs procedes d'utilisation
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
CN115698717A (zh) 2020-04-03 2023-02-03 基因泰克公司 癌症的治疗和诊断方法
WO2021207662A1 (fr) 2020-04-10 2021-10-14 Genentech, Inc. Utilisation d'il-22-fc pour le traitement ou la prévention de la pneumonie, du syndrome de détresse respiratoire aiguë ou du syndrome de libération de cytokines
TW202206111A (zh) 2020-04-24 2022-02-16 美商建南德克公司 使用抗ｃｄ７９ｂ免疫結合物之方法
US20230167198A1 (en) 2020-04-27 2023-06-01 The Regents Of The University Of California Isoform-independent antibodies to lipoprotein(a)
EP4143345A1 (fr) 2020-04-28 2023-03-08 Genentech, Inc. Procédés et compositions pour l'immunothérapie du cancer du poumon non à petites cellules
TW202200212A (zh) 2020-05-03 2022-01-01 中國大陸商聯寧（蘇州）生物製藥有限公司 包含抗-trop-2抗體之抗體藥物結合物
CN113993900B (zh) 2020-05-27 2023-08-04 舒泰神（北京）生物制药股份有限公司 特异性识别神经生长因子的抗体及其用途
EP4157462A1 (fr) 2020-06-02 2023-04-05 Dynamicure Biotechnology LLC Constructions anti-cd93 et leurs utilisations
CN116529260A (zh) 2020-06-02 2023-08-01 当康生物技术有限责任公司 抗cd93构建体及其用途
EP4165415A1 (fr) 2020-06-12 2023-04-19 Genentech, Inc. Méthodes et compositions pour une immunothérapie anticancéreuse
KR20230025691A (ko) 2020-06-16 2023-02-22 제넨테크, 인크. 삼중 음성 유방암을 치료하기 위한 방법과 조성물
EP4168118A1 (fr) 2020-06-18 2023-04-26 Genentech, Inc. Traitement avec des anticorps anti-tigit et des antagonistes de liaison à l'axe pd-1
AU2021291011A1 (en) 2020-06-19 2023-01-05 F. Hoffmann-La Roche Ag Antibodies binding to CD3 and CD19
US20220017637A1 (en) 2020-06-23 2022-01-20 Hoffmann-La Roche Inc. Agonistic cd28 antigen binding molecules targeting her2
CN115916830A (zh) 2020-06-25 2023-04-04 豪夫迈·罗氏有限公司 抗cd3/抗cd28双特异性抗原结合分子
EP4175668A1 (fr) 2020-07-06 2023-05-10 iOmx Therapeutics AG Anticorps de liaison à l'igv d'igsf11 (vsig3) et leurs utilisations
WO2022008468A1 (fr) 2020-07-07 2022-01-13 F. Hoffmann-La Roche Ag Tensioactifs alternatifs utilisés en tant que stabilisants pour formulations de protéines thérapeutiques
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
US20230322935A1 (en) 2020-07-29 2023-10-12 Dynamicure Biotechnology Llc Anti-cd93 constructs and uses thereof
JP2023536602A (ja) 2020-08-03 2023-08-28 ジェネンテック， インコーポレイテッド リンパ腫のための診断及び治療方法
EP4192868A1 (fr) 2020-08-05 2023-06-14 Juno Therapeutics, Inc. Anticorps anti-idiotypiques dirigés contre des domaines de liaison ciblés sur ror1 et compositions et procédés associés
CA3188426A1 (fr) 2020-08-07 2022-02-10 Yichin Liu Proteines de fusion de ligand flt3 et leurs procedes d'utilisation
TW202221026A (zh) 2020-08-14 2022-06-01 瑞士商Ａｃ 免疫有限公司 人源化抗ｔｄｐ－４３結合分子及其用途
EP4204448A2 (fr) 2020-08-27 2023-07-05 cureab GmbH Anticorps anti-golph2 pour la différenciation des macrophages et des cellules dendritiques
CA3194792A1 (fr) 2020-09-15 2022-03-24 Bayer Aktiengesellschaft Nouveaux anticorps anti-a2ap et leurs utilisations
CN116685351A (zh) 2020-09-17 2023-09-01 基因泰克公司 Empacta的结果：一项用于评估托珠单抗在患有covid-19肺炎的住院患者中的功效和安全性的随机、双盲、安慰剂对照、多中心研究
CN116406291A (zh) 2020-10-05 2023-07-07 基因泰克公司 用抗fcrh5/抗cd3双特异性抗体进行治疗的给药
JP2023545566A (ja) 2020-10-20 2023-10-30 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｐｄ－１軸結合アンタゴニストとｌｒｒｋ２阻害剤との併用療法
EP4232475A1 (fr) 2020-10-20 2023-08-30 Kantonsspital St. Gallen Anticorps ou fragments de liaison à l'antigène se liant spécifiquement à la gremlin-1 et leurs utilisations
WO2022093981A1 (fr) 2020-10-28 2022-05-05 Genentech, Inc. Polythérapie comprenant des inhibiteurs de ptpn22 et des antagonistes de liaison au pd-l1
JP2023547507A (ja) 2020-11-03 2023-11-10 ドイチェス クレブスフォルシュンクスツェントルム スチフトゥング デス エッフェントリヒェン レヒツ 標的細胞限定的で共刺激性の二重特異性かつ２価の抗ｃｄ２８抗体
US20220162329A1 (en) 2020-11-04 2022-05-26 Genentech, Inc. Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
EP4240766A2 (fr) 2020-11-04 2023-09-13 Genentech, Inc. Dosage sous-cutané d'anticorps bispécifiques anti-cd20/anti-cd3
JP2023548064A (ja) 2020-11-04 2023-11-15 ジェネンテック， インコーポレイテッド 抗ｃｄ２０／抗ｃｄ３二重特異性抗体及び抗ｃｄ７９ｂ抗体薬物コンジュゲートによる処置のための投与
EP4244254A1 (fr) 2020-11-16 2023-09-20 F. Hoffmann-La Roche AG Polythérapie avec des agonistes de cd40 ciblant fap
TW202237638A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 烏苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
TW202237639A (zh) 2020-12-09 2022-10-01 日商武田藥品工業股份有限公司 鳥苷酸環化酶ｃ（ｇｃｃ）抗原結合劑之組成物及其使用方法
WO2022132904A1 (fr) 2020-12-17 2022-06-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux humains ciblant le sars-cov-2
MX2023007846A (es) 2021-01-06 2023-07-07 F Hoffmann La Roche Ag Tratamiento conjunto que usa un anticuerpo biespecifico contra pd1-lag3 y un anticuerpo biespecifico de linfocitos t cd20.
WO2022162587A1 (fr) 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anticorps anti-sras-cov-2 et leur utilisation dans le traitement d'une infection par le sras-cov-2
CN117120084A (zh) 2021-01-28 2023-11-24 维肯芬特有限责任公司 用于调节b细胞介导的免疫应答的方法和手段
KR20230147099A (ko) 2021-01-28 2023-10-20 백신벤트 게엠베하 B 세포 매개 면역 반응을 조절하기 위한 방법 및 수단(method and means for modulating b-cell mediated immune responses)
WO2022162203A1 (fr) 2021-01-28 2022-08-04 Vaccinvent Gmbh Méthodes et moyens pour moduler des réponses immunitaires à médiation par des lymphocytes b
EP4291306A1 (fr) 2021-02-09 2023-12-20 University of Georgia Research Foundation, Inc. Anticorps monoclonaux humains dirigés contre des antigènes pneumococciques
US20240117011A1 (en) 2021-02-09 2024-04-11 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Antibodies targeting the spike protein of coronaviruses
JP2024506200A (ja) 2021-02-15 2024-02-09 武田薬品工業株式会社 細胞治療用組成物及びｔｇｆ－ｂシグナル伝達を調節する方法
CA3211686A1 (fr) 2021-02-26 2022-09-01 Bayer Aktiengesellschaft Inhibiteurs d'il-11 ou d'il-11 ra destines a etre utilises dans le traitement d'un saignement uterin anormal
TW202317612A (zh) 2021-03-01 2023-05-01 美商艾希利歐發展股份有限公司 用於治療癌症的ｃｔｌａ４及ｐｄ１／ｐｄｌ１抗體之組合
EP4301781A1 (fr) 2021-03-01 2024-01-10 Xilio Development, Inc. Combinaison d'anticorps ctla4 et pd1/pdl1 masqués pour le traitement du cancer
JP2024509169A (ja) 2021-03-03 2024-02-29 ソレント・セラピューティクス・インコーポレイテッド 抗ｂｃｍａ抗体を含む抗体－薬物コンジュゲート
TW202302646A (zh) 2021-03-05 2023-01-16 美商當康生物科技有限公司 抗vista構築體及其用途
IL305283A (en) 2021-03-15 2023-10-01 Genentech Inc Compositions and methods for the treatment of lupus nephritis
WO2022197877A1 (fr) 2021-03-19 2022-09-22 Genentech, Inc. Procédés et compositions pour une libération bio-orthogonale retardée d'agents cytotoxiques
JP2024511424A (ja) 2021-03-25 2024-03-13 ダイナミキュア バイオテクノロジー エルエルシー 抗ｉｇｆｂｐ７構築物およびその使用
IL307233A (en) 2021-03-30 2023-11-01 Bayer Ag Anti-SEMA3A antibodies and uses thereof
AR125344A1 (es) 2021-04-15 2023-07-05 Chugai Pharmaceutical Co Ltd Anticuerpo anti-c1s
AU2021443863A1 (en) 2021-04-30 2023-10-26 F. Hoffmann-La Roche Ag Dosing for treatment with anti-cd20/anti-cd3 bispecific antibody
EP4330282A1 (fr) 2021-04-30 2024-03-06 F. Hoffmann-La Roche AG Dosage pour un traitement combiné avec un anticorps bispécifique anti-cd20/anti-cd3 et un conjugué anticorps-médicament anti-cd79b
IL308351A (en) 2021-05-12 2024-01-01 Genentech Inc Methods for using anti-CD79B immunoconjugates to treat diffuse large B-cell lymphoma
BR112023023777A2 (pt) 2021-05-14 2024-01-30 Genentech Inc Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo
WO2022243261A1 (fr) 2021-05-19 2022-11-24 F. Hoffmann-La Roche Ag Molécules de liaison à l'antigène cd40 agonistes ciblant cea
AR126009A1 (es) 2021-06-02 2023-08-30 Hoffmann La Roche Moléculas agonistas de unión al antígeno cd28 que se dirigen a epcam
TW202306994A (zh) 2021-06-04 2023-02-16 日商中外製藥股份有限公司 抗ddr2抗體及其用途
KR20240019109A (ko) 2021-06-09 2024-02-14 에프. 호프만-라 로슈 아게 암의 치료에 이용하기 위한 특정 braf 억제제(패러독스 브레이크) 및 pd-1 축 결합 길항제의 조합물
CA3221924A1 (fr) 2021-06-11 2022-12-15 Genentech, Inc. Methode de traitement d'une bronchopneumopathie chronique obstructive avec un antagoniste de st2
WO2022266660A1 (fr) 2021-06-17 2022-12-22 Amberstone Biosciences, Inc. Constructions anti-cd3 et utilisations associées
WO2022263638A1 (fr) 2021-06-17 2022-12-22 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anticorps anti-sars-cov-2 et leur utilisation dans le traitement d'une infection par le sars-cov-2
JP7472405B2 (ja) 2021-06-25 2024-04-22 中外製薬株式会社 抗ｃｔｌａ－４抗体
WO2022270612A1 (fr) 2021-06-25 2022-12-29 中外製薬株式会社 Utilisation d'anticorps anti-ctla-4
WO2023283611A1 (fr) 2021-07-08 2023-01-12 Staidson Biopharma Inc. Anticorps reconnaissant spécifiquement le tnfr2 et leurs utilisations
CN115812082A (zh) 2021-07-14 2023-03-17 舒泰神（北京）生物制药股份有限公司 特异性识别cd40的抗体及其应用
WO2023004386A1 (fr) 2021-07-22 2023-01-26 Genentech, Inc. Compositions ciblant le cerveau et leurs méthodes d'utilisation
WO2023019092A1 (fr) 2021-08-07 2023-02-16 Genentech, Inc. Méthodes d'utilisation d'immunoconjugués anti-cd79b pour traiter un lymphome diffus à grandes cellules b
WO2023019239A1 (fr) 2021-08-13 2023-02-16 Genentech, Inc. Dosage d'anticorps anti-tryptase
CN117858905A (zh) 2021-08-19 2024-04-09 豪夫迈·罗氏有限公司 多价抗变体fc区抗体及使用方法
WO2023028591A1 (fr) 2021-08-27 2023-03-02 Genentech, Inc. Méthodes de traitement de pathologie de tau
TW202325727A (zh) 2021-08-30 2023-07-01 美商建南德克公司 抗聚泛素多特異性抗體
AU2022345251A1 (en) 2021-09-17 2024-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies
TW202321308A (zh) 2021-09-30 2023-06-01 美商建南德克公司 使用抗ｔｉｇｉｔ抗體、抗ｃｄ３８抗體及ｐｄ—１軸結合拮抗劑治療血液癌症的方法
WO2023081818A1 (fr) 2021-11-05 2023-05-11 American Diagnostics & Therapy, Llc (Adxrx) Anticorps monoclonaux contre des antigènes carcinoembryonnaires et leurs utilisations
WO2023086807A1 (fr) 2021-11-10 2023-05-19 Genentech, Inc. Anticorps anti-interleukine-33 et leurs utilisations
AR127692A1 (es) 2021-11-16 2024-02-21 Ac Immune Sa Anticuerpos anti-asc para uso en tratamientos antiinflamatorios
TW202337494A (zh) 2021-11-16 2023-10-01 美商建南德克公司 用莫蘇妥珠單抗治療全身性紅斑狼瘡（ｓｌｅ）之方法及組成物
AR128031A1 (es) 2021-12-20 2024-03-20 Hoffmann La Roche Anticuerpos agonistas anti-ltbr y anticuerpos biespecíficos que los comprenden
WO2023131901A1 (fr) 2022-01-07 2023-07-13 Johnson & Johnson Enterprise Innovation Inc. Matériaux et procédés de protéines de liaison à il-1beta
WO2023154824A1 (fr) 2022-02-10 2023-08-17 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux humains ciblant largement les coronavirus
TW202342519A (zh) 2022-02-16 2023-11-01 瑞士商Ａｃ 免疫有限公司 人源化抗ｔｄｐ－４３結合分子及其用途
TW202342520A (zh) 2022-02-18 2023-11-01 美商樂天醫藥生技股份有限公司 抗計畫性死亡配體１（ｐｄ—ｌ１）抗體分子、編碼多核苷酸及使用方法
WO2023173026A1 (fr) 2022-03-10 2023-09-14 Sorrento Therapeutics, Inc. Conjugués anticorps-médicament et leurs utilisations
TW202346365A (zh) 2022-03-23 2023-12-01 瑞士商赫孚孟拉羅股份公司 抗ｃｄ２０／抗ｃｄ３雙特異性抗體及化學療法之組合治療
WO2023192827A1 (fr) 2022-03-26 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps bispécifiques à enveloppe du vih-1 et leur utilisation
WO2023186756A1 (fr) 2022-03-28 2023-10-05 F. Hoffmann-La Roche Ag Variants d'interféron gamma et molécules de liaison à l'antigène les comprenant
WO2023192881A1 (fr) 2022-03-28 2023-10-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps neutralisants dirigés contre la protéine d'enveloppe (env) du vih-1 et leur utilisation
WO2023191816A1 (fr) 2022-04-01 2023-10-05 Genentech, Inc. Dosage pour traitement avec des anticorps bispécifiques anti-fcrh5/anti-cd3
WO2023194565A1 (fr) 2022-04-08 2023-10-12 Ac Immune Sa Molécules de liaison anti-tdp-43
US20230406930A1 (en) 2022-04-13 2023-12-21 Genentech, Inc. Pharmaceutical compositions of therapeutic proteins and methods of use
WO2023198727A1 (fr) 2022-04-13 2023-10-19 F. Hoffmann-La Roche Ag Compositions pharmaceutiques à base d'anticorps bispécifiques anti-cd20/anti-cd3 et procédés d'utilisation
WO2023203177A1 (fr) 2022-04-20 2023-10-26 Kantonsspital St. Gallen Anticorps ou fragments de liaison à l'antigène se liant de manière spécifique à gremlin-1 et à gremlin-2 et leurs utilisations
WO2023215737A1 (fr) 2022-05-03 2023-11-09 Genentech, Inc. Anticorps anti-ly6e, immunoconjugués et leurs utilisations
WO2023219613A1 (fr) 2022-05-11 2023-11-16 Genentech, Inc. Dosage pour le traitement avec des anticorps bispécifiques anti-fcrh5/anti-cd3
WO2023235699A1 (fr) 2022-05-31 2023-12-07 Jounce Therapeutics, Inc. Anticorps dirigés contre lilrb4 et leurs utilisations
US11807689B1 (en) * 2022-06-01 2023-11-07 Tg Therapeutics, Inc. Anti-CD20 antibody compositions
WO2023240058A2 (fr) 2022-06-07 2023-12-14 Genentech, Inc. Méthodes pronostiques et thérapeutiques pour le cancer
WO2023237706A2 (fr) 2022-06-08 2023-12-14 Institute For Research In Biomedicine (Irb) Anticorps inter-spécifiques, utilisations et procédés de découverte de ceux-ci
WO2024015897A1 (fr) 2022-07-13 2024-01-18 Genentech, Inc. Dosage pour traitement avec anticorps bispécifiques anti-fcrh5/anti-cd3
WO2024020432A1 (fr) 2022-07-19 2024-01-25 Genentech, Inc. Dosage pour traitement avec des anticorps bispécifiques anti-fcrh5/anti-cd3
WO2024020407A1 (fr) 2022-07-19 2024-01-25 Staidson Biopharma Inc. Anticorps reconnaissant spécifiquement l'atténuateur de lymphocytes b et t (btla) et leurs utilisations
WO2024020579A1 (fr) 2022-07-22 2024-01-25 Bristol-Myers Squibb Company Anticorps se liant au pad4 humain et leurs utilisations
WO2024020564A1 (fr) 2022-07-22 2024-01-25 Genentech, Inc. Molécules de liaison à l'antigène anti-steap1 et leurs utilisations
WO2024030829A1 (fr) 2022-08-01 2024-02-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps monoclonaux se liant à la face inférieure de la neuraminidase virale de la grippe
WO2024028731A1 (fr) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Protéines de liaison de récepteur de transferrine pour traitement de tumeurs cérébrales
WO2024028732A1 (fr) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Constructions de liaison à cd98 pour le traitement de tumeurs cérébrales
WO2024044779A2 (fr) 2022-08-26 2024-02-29 Juno Therapeutics, Inc. Anticorps et récepteurs antigéniques chimériques spécifiques d'un ligand 3 de type delta (dll3)
WO2024049949A1 (fr) 2022-09-01 2024-03-07 Genentech, Inc. Méthodes thérapeutiques et diagnostiques pour cancer de la vessie
WO2024054929A1 (fr) 2022-09-07 2024-03-14 Dynamicure Biotechnology Llc Constructions anti-vista et leurs utilisations
WO2024054822A1 (fr) 2022-09-07 2024-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps du sars-cov -2 modifiés ayant une largeur de neutralisation accrue
WO2024064826A1 (fr) 2022-09-22 2024-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anticorps neutralisants dirigés contre la protéine plasmodium falciparum circumsporozoïte et leur utilisation
WO2024068996A1 (fr) 2022-09-30 2024-04-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anticorps anti-sars-cov-2 et utilisation associée dans le traitement d'une infection par sars-cov-2

Family Cites Families (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7097A (en) 1850-02-19 Elevating- and lowering carriage-tops
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
EP0173494A3 (fr) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Récepteurs chimériques par liaison et expression de l'ADN
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US6893625B1 (en) 1986-10-27 2005-05-17 Royalty Pharma Finance Trust Chimeric antibody with specificity to human B cell surface antigen
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0365685B1 (fr) 1988-03-30 1995-01-18 Toray Industries, Inc. Préparation lyophilisée contenant un fragment Fab' marqué à la peroxydase de raifort d'un anticorps monoclonal anti interféron béta humain et du tréhalose ; kit EIA contenant cette préparation
US5047335A (en) 1988-12-21 1991-09-10 The Regents Of The University Of Calif. Process for controlling intracellular glycosylation of proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
WO1992007466A1 (fr) 1990-11-05 1992-05-14 Bristol-Myers Squibb Company Therapie synergique par combinaisons d'anticorps anti-tumeur avec des agents biologiquement actifs
CA2149329C (fr) 1992-11-13 2008-07-15 Darrell R. Anderson Utilisation d'anticorps hybrides et radioisotopiques diriges contre l'antigene de restriction de la differenciation des lymphocytes b humains pour le traitement du lymphome b
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US7744877B2 (en) 1992-11-13 2010-06-29 Biogen Idec Inc. Expression and use of anti-CD20 Antibodies
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US20030180290A1 (en) 1995-06-07 2003-09-25 Idec Pharmaceuticals Corporation Anti-CD80 antibody having ADCC activity for ADCC mediated killing of B cell lymphoma cells alone or in combination with other therapies
JPH11510170A (ja) 1995-07-27 1999-09-07 ジェネンテック インコーポレーテッド タンパク質の処方
US6001358A (en) 1995-11-07 1999-12-14 Idec Pharmaceuticals Corporation Humanized antibodies to human gp39, compositions containing thereof
EP0938334A4 (fr) 1996-07-26 2004-12-15 Smithkline Beecham Corp Methode amelioree de traitement de maladies de l'organisme induites par des cellules immunes
UA76934C2 (en) 1996-10-04 2006-10-16 Chugai Pharmaceutical Co Ltd Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody
EP1864999B1 (fr) 1996-11-27 2009-03-18 Genentech, Inc. Purification d'affinité de polypeptide sur une protéine d'une matrice
US6306393B1 (en) 1997-03-24 2001-10-23 Immunomedics, Inc. Immunotherapy of B-cell malignancies using anti-CD22 antibodies
US6991790B1 (en) 1997-06-13 2006-01-31 Genentech, Inc. Antibody formulation
EP0999853B1 (fr) 1997-06-13 2003-01-02 Genentech, Inc. Formulation stabilisee renfermant un anticorps
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
US20040191256A1 (en) 1997-06-24 2004-09-30 Genentech, Inc. Methods and compositions for galactosylated glycoproteins
DE69830315T2 (de) 1997-06-24 2006-02-02 Genentech Inc., San Francisco Galactosylierte glykoproteine enthaltende zusammensetzungen und verfahren zur deren herstellung
ATE419009T1 (de) 1997-10-31 2009-01-15 Genentech Inc Methoden und zusammensetzungen bestehend aus glykoprotein-glykoformen
US6528624B1 (en) 1998-04-02 2003-03-04 Genentech, Inc. Polypeptide variants
SK14812000A3 (sk) 1998-04-03 2001-08-06 Chugai Seiyaku Kabushiki Kaisha Chimérny reťazec protilátky, chimérna protilátka, v oblasť, humanizovaný reťazec protilátky, humanizovaná protilátka, dna, expresný vektor, hostiteľ, spôsob prípravy a liečivo
AU3657899A (en) 1998-04-20 1999-11-08 James E. Bailey Glycosylation engineering of antibodies for improving antibody-dependent cellular cytotoxicity
ATE321066T1 (de) 1998-05-06 2006-04-15 Genentech Inc Anti-her2 antikörperzusammensetzung
EP1112084B2 (fr) 1998-08-11 2012-04-25 Biogen Idec Inc. Therapies d'association contre les lymphomes malins a cellules b par l'administration d'anticorps anti-cd20
WO2000010007A2 (fr) 1998-08-17 2000-02-24 California Institute Of Technology Dispositifs et procedes d'analyse de solutes non ioniques
US6224866B1 (en) 1998-10-07 2001-05-01 Biocrystal Ltd. Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors
MY155913A (en) 1998-11-09 2015-12-15 Biogen Inc Chimeric anti-cd20 antibody treatment of patients receiving bmt or pbsc transpants
WO2000027428A1 (fr) 1998-11-09 2000-05-18 Idec Pharmaceuticals Corporation Traitement d'affections malignes hematologiques associees a des cellules tumorales en circulation au moyen d'un anticorps chimere anti-cd 20
HUP0104865A3 (en) * 1999-01-15 2004-07-28 Genentech Inc Polypeptide variants with altered effector function
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
EP2275540B1 (fr) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Procédé de contrôle de l'activité de molécule fonctionnelle immunologique
WO2000067796A1 (fr) 1999-05-07 2000-11-16 Genentech, Inc. Traitement de maladies auto-immunes au moyen d'antagonistes se liant aux marqueurs de surface de lymphocytes b
US7074403B1 (en) 1999-06-09 2006-07-11 Immunomedics, Inc. Immunotherapy of autoimmune disorders using antibodies which target B-cells
JP2003528805A (ja) 1999-07-12 2003-09-30 ジェネンテック・インコーポレーテッド Ｃｄ２０に結合するアンタゴニストを用いた異種抗原に対する免疫応答のブロッキング
US8557244B1 (en) 1999-08-11 2013-10-15 Biogen Idec Inc. Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody
CN100389825C (zh) 1999-08-11 2008-05-28 拜奥根Idec公司 用抗cd20抗体治疗累及骨髓的非霍奇金淋巴瘤患者
US6451284B1 (en) 1999-08-11 2002-09-17 Idec Pharmaceuticals Corporation Clinical parameters for determining hematologic toxicity prior to radioimmunotheraphy
CN1169952C (zh) 1999-10-10 2004-10-06 中国医学科学院中国协和医科大学血液学研究所血液病医院 抗cd20单克隆抗体的重链和轻链可变区基因及其应用
MXPA02004599A (es) 1999-11-08 2002-10-23 Idec Pharma Corp Tratamiento de tumores malignos de celula b utilizando anticuerpos anti-cd40l en combinacion con anticuerpos anti-cd20 y/o agentes quimioterapeuticos y radioterapia.
US20020006404A1 (en) 1999-11-08 2002-01-17 Idec Pharmaceuticals Corporation Treatment of cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
US20020028178A1 (en) 2000-07-12 2002-03-07 Nabil Hanna Treatment of B cell malignancies using combination of B cell depleting antibody and immune modulating antibody related applications
JP2004500108A (ja) 2000-03-24 2004-01-08 マイクロメット　アーゲー Ｎｋｇ２ｄレセプター複合体のエピトープへの結合部位を含む多機能ポリペプチド
KR20020091170A (ko) 2000-03-31 2002-12-05 아이덱 파마슈티칼즈 코포레이션 Ｂ 세포 림프종의 치료를 위한 항-사이토카인 항체 또는길항제 및 항-ｃｄ２０의 조합된 사용
CN1437478A (zh) 2000-04-25 2003-08-20 Idec药物公司 瑞图希单抗的鞘内施用,用于中枢神经系统淋巴瘤的治疗
WO2001097858A2 (fr) 2000-06-20 2001-12-27 Idec Pharmaceuticals Corporation Traitement de maladies associees aux cellules beta telles que les maladies auto-immunes a caractere malin par combinaison anticorps anti-cd20 froid/anticorps anti-cd22 radiomarque
JP2004502742A (ja) 2000-07-12 2004-01-29 アイデック　ファーマスーティカルズ　コーポレイション Ｂ細胞を消滅させる抗体及び免疫調節抗体を併用するｂ細胞悪性疾患の治療関連出願
JP4795619B2 (ja) 2000-07-31 2011-10-19 バイオレックス・セラピューティクス インコーポレイテッド ウキクサにおける生物学的に活性なポリペプチド類の発現
DE10043452A1 (de) 2000-09-04 2002-03-14 Basf Ag Formkörper mit einer tonmineralischen Beschichtung
CA2422076A1 (fr) 2000-09-18 2002-03-21 Idec Pharmaceutical Corporation Polytherapie pour le traitement de maladies auto-immunes utilisant une combinaison d'anticorps d'immunoregulation/de depletion de cellules b
AU2002213357A1 (en) 2000-10-20 2002-05-06 Idec Pharmaceuticals Corporation Variant igg3 rituxan r and therapeutic use thereof
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20020159996A1 (en) 2001-01-31 2002-10-31 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
US20030103971A1 (en) 2001-11-09 2003-06-05 Kandasamy Hariharan Immunoregulatory antibodies and uses thereof
US20030211107A1 (en) 2002-01-31 2003-11-13 Kandasamy Hariharan Use of CD23 antagonists for the treatment of neoplastic disorders
WO2002060485A2 (fr) 2001-01-31 2002-08-08 Idec Pharmaceuticals Corporation Anticorps immunoregulateurs et ses utilisations
AU2002251913A1 (en) 2001-02-02 2002-08-19 Millennium Pharmaceuticals, Inc. Hybrid antibodies and uses thereof
US20030077826A1 (en) 2001-02-02 2003-04-24 Lena Edelman Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC)
US20030003097A1 (en) 2001-04-02 2003-01-02 Idec Pharmaceutical Corporation Recombinant antibodies coexpressed with GnTIII
DE60239931D1 (de) 2001-04-02 2011-06-16 Genentech Inc Kombinationstherapie
WO2003061694A1 (fr) 2001-05-10 2003-07-31 Seattle Genetics, Inc. Immunosuppression de la reponse immune humorale par des anticorps anti-cd20
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
WO2004006955A1 (fr) 2001-07-12 2004-01-22 Jefferson Foote Anticorps super humanises
NZ592087A (en) 2001-08-03 2012-11-30 Roche Glycart Ag Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity
IL159422A0 (en) 2001-09-20 2004-06-01 Cornell Res Foundation Inc Methods and compositions for treating or preventing skin disorders using binding agents specific for prostate-specific membrane antigen
ES2326964T3 (es) 2001-10-25 2009-10-22 Genentech, Inc. Composiciones de glicoproteina.
US20040093621A1 (en) * 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
ES2402527T3 (es) 2001-12-27 2013-05-06 Glycofi, Inc. Procedimientos para obtener estructuras de carbohidrato de tipo mamífero mediante ingeniería genética
US7432063B2 (en) 2002-02-14 2008-10-07 Kalobios Pharmaceuticals, Inc. Methods for affinity maturation
CA2476166C (fr) 2002-02-14 2011-11-15 Immunomedics, Inc. Anticorps anti-cd20 et proteines hybrides desdits anticorps, et methodes d'utilisation
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20030180292A1 (en) 2002-03-14 2003-09-25 Idec Pharmaceuticals Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy
KR101070518B1 (ko) 2002-03-19 2011-10-05 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서의 ｇｎｔⅲ 발현
PT1490405E (pt) 2002-03-21 2007-11-07 Lilly Co Eli Anticorpos humanos anti-ligando de hfas antagonistas e fragmentos dos mesmos
WO2003080672A1 (fr) 2002-03-22 2003-10-02 Aprogen, Inc. Anticorps humanise et procede de preparation correspondant
US20030190689A1 (en) 2002-04-05 2003-10-09 Cell Signaling Technology,Inc. Molecular profiling of disease and therapeutic response using phospho-specific antibodies
US7691568B2 (en) * 2002-04-09 2010-04-06 Kyowa Hakko Kirin Co., Ltd Antibody composition-containing medicament
AU2003236019A1 (en) * 2002-04-09 2003-10-20 Kyowa Hakko Kirin Co., Ltd. Drug containing antibody composition appropriate for patient suffering from Fc Gamma RIIIa polymorphism
AU2003251597A1 (en) 2002-06-19 2004-01-06 Abgenix, Inc. Method for predicting response to epidermal growth factor receptor-directed therapy
EP1534335B9 (fr) 2002-08-14 2016-01-13 Macrogenics, Inc. Anticorps specifiques du recepteur fcgammariib et procedes d'utilisation de ces anticorps
SI1539966T1 (sl) 2002-09-12 2010-10-29 Greenovation Biotech Gmbh Postopek za produkcijo proteinov
SI1558648T1 (sl) 2002-10-17 2012-05-31 Genmab As Človeška monoklonalna protitelesa proti CD
AU2003298799A1 (en) 2002-12-02 2004-06-23 Abgenix, Inc. Antibodies directed to phospholipase a2 and uses thereof
DE60332957D1 (de) 2002-12-16 2010-07-22 Genentech Inc Immunoglobulinvarianten und deren verwendungen
AU2003297023A1 (en) 2002-12-16 2004-07-29 Genentech, Inc. Transgenic mice expressing human cd20
CA2549932C (fr) 2002-12-20 2013-08-20 Greenovation Biotech Gmbh Ameliorations apportees ou associees a la production de proteines
US7960512B2 (en) 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP2368578A1 (fr) 2003-01-09 2011-09-28 Macrogenics, Inc. Identification et ingénierie d'anticorps avec régions FC de variante et procédés d'utilisation associés
ES2574993T3 (es) 2003-01-22 2016-06-23 Roche Glycart Ag Construcciones de fusión y uso de las mismas para producir anticuerpos con mayor afinidad de unión al receptor de Fc y función efectora
CA2513113A1 (fr) 2003-01-23 2004-08-05 Genentech, Inc. Procedes de production d'anticoprs humanises et d'amelioration du rendement d'anticorps ou de fragments de liaison d'antigenes en culture cellulaire
EP1603948A1 (fr) 2003-03-14 2005-12-14 Pharmacia Corporation Anticorps specifiques du recepteur d'igf-i pour le traitement de cancers
ES2322267T3 (es) 2003-04-09 2009-06-18 Genentech, Inc. Terapia de una enfermedad autoinmunologica en un paciente que presenta una respuesta inadecuada a un inhibidor de tnf-alfa.
AR044388A1 (es) 2003-05-20 2005-09-07 Applied Molecular Evolution Moleculas de union a cd20
KR20060027801A (ko) 2003-06-05 2006-03-28 제넨테크, 인크. Ｂ 세포 장애에 대한 조합 요법
US20050163775A1 (en) 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
ZA200600798B (en) 2003-07-29 2007-06-27 Genentech Inc Assay for human anti CD20 antibodies and uses therefor
EP1660534A2 (fr) 2003-08-22 2006-05-31 MedImmune, Inc. Humanisation d'anticorps
MXPA06002134A (es) 2003-08-29 2006-05-31 Genentech Inc Terapia de trastornos oculares.
EA036531B1 (ru) 2003-11-05 2020-11-19 Роше Гликарт Аг Гуманизированное антитело типа ii к cd20 (варианты), фармацевтическая композиция, содержащая эти варианты антитела, и их применение
AU2004303848A1 (en) 2003-12-19 2005-07-07 Genentech, Inc. Detection of CD20 in transplant rejection
EP1696955A2 (fr) 2003-12-19 2006-09-06 Genentech, Inc. Detection cd20 pour traitement des maladies auto-immunes
US7968690B2 (en) 2003-12-23 2011-06-28 Rinat Neuroscience Corp. Agonist anti-trkC antibodies and methods using same
AU2005214988A1 (en) 2004-02-17 2005-09-01 Absalus, Inc. Super-humanized antibodies against respiratory syncytial virus
RU2006140374A (ru) 2004-04-16 2008-05-27 Дженентек, Инк. (Us) Лечение нарушений
KR20070012826A (ko) 2004-04-16 2007-01-29 제넨테크, 인크. 항체에 대한 분석법
EP1735000A2 (fr) 2004-04-16 2006-12-27 Genentech, Inc. Methode permettant d'augmenter l'appauvrissement des lymphocytes b
CN1980697A (zh) 2004-05-05 2007-06-13 健泰科生物技术公司 通过使用抗cd20抗体预防自身免疫病
EP1769243A2 (fr) 2004-05-15 2007-04-04 Genentech, Inc. Système de criblage croisé et méthodes pour détecter une molécule ayant une affinité de liaison pour une molécule cible
AR049292A1 (es) 2004-06-04 2006-07-12 Genentech Inc Metodo para tratar lupus con un anticuerpo cd20
US20060051345A1 (en) 2004-06-04 2006-03-09 Genentech, Inc. Method for treating multiple sclerosis
US7501121B2 (en) 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
BRPI0513100A (pt) 2004-07-22 2007-10-23 Genentech Inc métodos de tratamento da sìndrome de sjÍgren e artigos manufaturados
CA2577133A1 (fr) 2004-08-19 2006-03-23 Genentech, Inc. Variants de polypeptides dotes d'une fonction effectrice modifiee
CN101048428A (zh) 2004-09-08 2007-10-03 健泰科生物技术公司 利用死亡受体配体和cd20抗体的方法
MX2007002855A (es) 2004-09-08 2007-04-27 Genentech Inc Metodos para usar ligandos de receptor de muerte y anticuerpos cd20.
MX2007002883A (es) 2004-09-13 2007-06-15 Macrogenics Inc Anticuerpos humanizados contra el virus de nilo occidental y usos terapeuticos y profilacticos del mismo.
WO2006041680A2 (fr) 2004-10-05 2006-04-20 Genentech, Inc. Methode de traitement de l'angeite
TW200635607A (en) 2004-12-15 2006-10-16 Elan Pharm Inc Humanized Aβ antibodies for use in improving cognition
KR20070086218A (ko) 2004-12-17 2007-08-27 제넨테크, 인크. 자가면역 질환에 대한 이전 요법에 실패했던 환자에서의,자가면역 질환의 항-혈관신생 요법
EP1833970A2 (fr) 2004-12-22 2007-09-19 Genentech, Inc. Procedes pour la production d'une pluralite de proteines transmembranaires solubles
GT200600020A (es) 2005-01-13 2006-11-08 Procedimiento de tratamiento
DOP2006000029A (es) 2005-02-07 2006-08-15 Genentech Inc Antibody variants and uses thereof. (variantes de un anticuerpo y usos de las mismas)
TW200714289A (en) 2005-02-28 2007-04-16 Genentech Inc Treatment of bone disorders
AR053579A1 (es) 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
KR20070122497A (ko) 2005-04-22 2007-12-31 제넨테크, 인크. Ｃｄ20 항체로 치매 또는 알츠하이머병을 치료하는 방법
KR20080025066A (ko) 2005-05-18 2008-03-19 바이오겐 아이덱 인크. 섬유성 상태의 치료 방법
JP2008545958A (ja) 2005-05-20 2008-12-18 ジェネンテック・インコーポレーテッド 自己免疫性疾患の被検体の生体試料の前処理
WO2006133148A2 (fr) 2005-06-03 2006-12-14 Genentech, Inc. Methode de production d'anticorps presentant une fonction amelioree
US20070071745A1 (en) 2005-08-26 2007-03-29 Pablo Umana Modified antigen binding molecules with altered cell signaling activity
MY149159A (en) 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
CA2629306A1 (fr) 2005-11-23 2007-05-31 Genentech, Inc. Procedes et compositions lies a des analyses de lymphocytes b
WO2007064911A1 (fr) 2005-12-02 2007-06-07 Biogen Idec Inc. Anticorps anti-souris cd20 et leurs utilisations
US7708944B1 (en) 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
JP2010527325A (ja) 2007-04-02 2010-08-12 ジェネンテック， インコーポレイテッド Ｂ細胞アンタゴニストに応答する関節リウマチを予測するバイオマーカー
WO2008157282A1 (fr) 2007-06-18 2008-12-24 Genentech, Inc. Marqueurs biologiques prédictifs d'une réponse d'arthrite rhumatoïde à des antagonistes de cellule b
SI3597659T1 (sl) 2007-07-09 2023-04-28 Genentech, Inc. Preprečevanje redukcije disulfidne vezi med rekombinantno proizvodnjo polipeptidov
KR100898362B1 (ko) 2007-07-10 2009-05-18 주식회사 그리폰 다목적 신발
KR101234436B1 (ko) 2007-09-05 2013-02-18 로슈 글리카트 아게 유형 ⅰ 및 유형 ⅱ 항-ｃｄ２０ 항체를 사용하는 병용 치료요법
GB0718684D0 (en) 2007-09-24 2007-10-31 Roche Products Ltd Treatment method
US20090214561A1 (en) 2007-09-24 2009-08-27 David Robert Close Treatment method
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090110688A1 (en) 2007-10-24 2009-04-30 Georg Fertig Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor
RS53850B2 (sr) 2007-10-30 2018-07-31 Genentech Inc Pročišćavanje antitela hromatografijom izmene katjona
US20090162351A1 (en) 2007-12-21 2009-06-25 Depuy Spine, Inc. Transdiscal administration of inhibitors of p38 MAP kinase
KR101247418B1 (ko) 2007-12-21 2013-03-25 에프. 호프만-라 로슈 아게 항체 제형
CA2708951A1 (fr) 2007-12-21 2009-07-09 Genetech, Inc. Cristallisation d'anticorps anti-cd20
JP2011507897A (ja) 2007-12-21 2011-03-10 ジェネンテック， インコーポレイテッド リツキシマブ抵抗性関節リウマチ患者の治療
AR072947A1 (es) 2008-03-25 2010-10-06 Glycart Biotechnology Ag Terapia de combinacion de un anticuerpo anti-cd20 de tipo ii con citotoxicidad, celular dependiente de anticuerpos (ccda) aumentada, composicion farmaceutica, anticuerpo anti-cd20 de tipo ii
WO2009134738A1 (fr) 2008-04-29 2009-11-05 Genentech, Inc. Réponses à des immunisations chez des patients atteints de polyarthrite rhumatoïde traités avec un anticorps anti-cd20
US8021850B2 (en) 2008-07-14 2011-09-20 Ribo Guo Universal tandem solid-phases based immunoassay
TW201014605A (en) 2008-09-16 2010-04-16 Genentech Inc Methods for treating progressive multiple sclerosis
JP2012509270A (ja) 2008-11-17 2012-04-19 ジェネンテック， インコーポレイテッド 生理的条件下での高分子の凝集を低減するための方法及び製剤
PE20120169A1 (es) 2008-11-17 2012-02-29 Genentech Inc Metodo y formulacion para reducir la agregacion de una macromolecula bajo condiciones fisiologicas
AR075982A1 (es) 2009-03-31 2011-05-11 Roche Glycart Ag Terapia de combinacion de un anticuerpo afucosilado y una o mas de las citoquinas seleccionadas de gm- csf humano, m -csf humano y/o il-3 humano y composicion
TWI409079B (zh) 2009-08-14 2013-09-21 Roche Glycart Ag 非典型岩藻醣化ｃｄ２０抗體與苯達莫斯汀（ｂｅｎｄａｍｕｓｔｉｎｅ）之組合療法
AU2010281867A1 (en) 2009-08-14 2012-02-02 Roche Glycart Ag Combination therapy of an afucosylated CD20 antibody with fludarabine and/or mitoxantrone
EP3211094A3 (fr) 2009-09-03 2017-11-01 F. Hoffmann-La Roche AG Procédés pour traiter, diagnostiquer, et surveiller la polyarthrite rhumatoïde
AR078161A1 (es) 2009-09-11 2011-10-19 Hoffmann La Roche Formulaciones farmaceuticas muy concentradas de un anticuerpo anti cd20. uso de la formulacion. metodo de tratamiento.
WO2011131749A1 (fr) 2010-04-23 2011-10-27 Glaxo Group Limited Nouveaux macrolides à 14 et 15 chaînons pour le traitement de maladies inflammatoires à dominance en neutrophiles
CN103153341B (zh) 2010-08-03 2015-05-27 霍夫曼-拉罗奇有限公司 慢性淋巴细胞性白血病(cll)生物标志物
TW201208703A (en) 2010-08-17 2012-03-01 Roche Glycart Ag Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
KR20140022815A (ko) 2011-02-28 2014-02-25 제넨테크, 인크. B-세포 길항제에 대한 반응을 예측하기 위한 생물학적 마커 및 방법
US8592156B2 (en) 2011-08-08 2013-11-26 Roche Molecular Systems, Inc. Predicting response to anti-CD20 therapy in DLBCL patients
US20140172120A1 (en) 2012-09-06 2014-06-19 Freedom Innovations, Llc Method and system for a prosthetic device with multiple levels of functionality enabled through multiple control systems
KR20200110711A (ko) 2012-09-07 2020-09-24 제넨테크, 인크. Ｉｉ형 항-ｃｄ20 항체와 선택적 ｂｃｌ-2 억제제와의 병용 치료요법

Also Published As

Publication number Publication date
ES2615507T3 (es) 2017-06-07
RS51334B (en) 2011-02-28
RS55723B1 (sr) 2017-07-31
HRP20151418T1 (hr) 2016-01-29
NO20220263A1 (no) 2006-08-03
CA2544865C (fr) 2019-07-09
ES2708095T3 (es) 2019-04-08
RS54450B1 (en) 2016-06-30
JP2012254083A (ja) 2012-12-27
NO20220904A1 (no) 2006-08-03
JP2018027088A (ja) 2018-02-22
CY1120252T1 (el) 2019-07-10
EP2348051B1 (fr) 2018-12-19
JP2010081940A (ja) 2010-04-15
SG10202008722QA (en) 2020-10-29
EA036531B1 (ru) 2020-11-19
DK2380910T3 (en) 2015-10-19
MX337587B (es) 2016-03-11
US20160075794A1 (en) 2016-03-17
SI2380910T1 (sl) 2015-11-30
IL232954A (en) 2015-09-24
CY1121206T1 (el) 2020-05-29
CN104829719A (zh) 2015-08-12
SG10201504094SA (en) 2015-06-29
AU2004287643B2 (en) 2011-11-17
BRPI0416262A (pt) 2007-01-09
KR20110129990A (ko) 2011-12-02
ME01775B (fr) 2011-02-28
PL2348051T3 (pl) 2019-05-31
JP2008500017A (ja) 2008-01-10
EA025962B1 (ru) 2017-02-28
IL175367A (en) 2014-11-30
HRP20170398T1 (hr) 2017-05-19
US20160076009A1 (en) 2016-03-17
BR122020013239B1 (pt) 2022-05-10
KR101364858B1 (ko) 2014-02-19
LTC2380910I2 (lt) 2018-01-25
NO20210499A1 (no) 2006-08-03
PL2380910T3 (pl) 2015-12-31
ME02332B (fr) 2016-06-30
NO346533B1 (no) 2022-09-26
US20050123546A1 (en) 2005-06-09
PT2380910E (pt) 2015-11-26
SI2380911T1 (en) 2018-07-31
CY2015001I1 (el) 2016-06-22
JP4653109B2 (ja) 2011-03-16
NZ588860A (en) 2012-03-30
PL2380911T3 (pl) 2018-10-31
NO346167B1 (no) 2022-04-04
CN1902231A (zh) 2007-01-24
PL1692182T3 (pl) 2010-09-30
HUE026669T2 (en) 2016-06-28
PT2348051T (pt) 2019-02-04
WO2005044859A2 (fr) 2005-05-19
EA015009B1 (ru) 2011-04-29
HUE042914T2 (hu) 2019-07-29
SI2077282T1 (sl) 2017-03-31
IL207347A (en) 2015-08-31
EP2380910A1 (fr) 2011-10-26
NO347800B1 (no) 2024-03-25
DK2077282T3 (en) 2017-01-30
HRP20100303T1 (hr) 2010-07-31
WO2005044859A3 (fr) 2005-08-04
SI1692182T1 (sl) 2010-06-30
SI2348051T1 (sl) 2019-03-29
AU2004287643A1 (en) 2005-05-19
ATE463513T1 (de) 2010-04-15
PT2380911T (pt) 2018-07-04
DK2348051T3 (en) 2019-03-18
KR101364902B1 (ko) 2014-02-21
LT2348051T (lt) 2019-02-25
KR20060130579A (ko) 2006-12-19
US20210002382A1 (en) 2021-01-07
JP6125770B2 (ja) 2017-05-10
JP2015134814A (ja) 2015-07-27
SG160348A1 (en) 2010-04-29
US20090010921A1 (en) 2009-01-08
CY2016004I1 (el) 2016-08-31
IL175367A0 (en) 2006-09-05
EP2348051A2 (fr) 2011-07-27
EP2077282A3 (fr) 2009-08-05
ES2550311T3 (es) 2015-11-06
EP1692182B1 (fr) 2010-04-07
DK1692182T3 (da) 2010-05-31
BRPI0416262B1 (pt) 2022-04-12
CN102373215B (zh) 2014-07-30
PL2077282T3 (pl) 2017-08-31
NO341893B1 (no) 2018-02-12
EA202091901A1 (ru) 2020-11-24
LT2077282T (lt) 2017-03-10
RS58420B1 (sr) 2019-04-30
ECSP21023271A (es) 2021-05-31
AU2004287643C1 (en) 2012-05-31
CA2544865A1 (fr) 2005-05-19
CY2016004I2 (el) 2016-08-31
HK1167681A1 (en) 2012-12-07
DE602004026470D1 (de) 2010-05-20
EP2380911A1 (fr) 2011-10-26
ES2341009T3 (es) 2010-06-14
HRP20181204T1 (hr) 2018-09-21
LU93001I2 (fr) 2016-05-17
EP2077282B1 (fr) 2016-12-28
CR11848A (es) 2011-04-04
MXPA06004836A (es) 2006-07-06
HRP20170398T2 (hr) 2019-06-28
EA200600905A1 (ru) 2006-12-29
UA91823C2 (ru) 2010-09-10
EP2380911B1 (fr) 2018-05-09
CN102373215A (zh) 2012-03-14
HRP20190333T1 (hr) 2019-05-03
IL207347A0 (en) 2010-12-30
PT2077282T (pt) 2017-02-14
CY1110301T1 (el) 2015-01-14
NO347530B1 (no) 2023-12-11
ECSP066603A (es) 2006-10-17
LU92632I2 (fr) 2015-11-02
IL232954A0 (en) 2014-07-31
ZA200604547B (en) 2007-07-25
NZ547589A (en) 2009-05-31
RS57466B1 (sr) 2018-09-28
TNSN06126A1 (en) 2007-11-15
CN102373214A (zh) 2012-03-14
HUE031632T2 (en) 2017-07-28
EP2348051A3 (fr) 2012-12-19
DK2380911T3 (en) 2018-08-06
ME03330B (fr) 2019-10-20
PT1692182E (pt) 2010-05-13
HUS1600013I1 (hu) 2016-04-28
FR15C0076I2 (fr) 2016-03-11
EP2380910B1 (fr) 2015-09-30
HK1100005A1 (en) 2007-08-31
EP2077282A2 (fr) 2009-07-08
EA201300481A1 (ru) 2014-01-30
KR20120104419A (ko) 2012-09-20
CN1902231B (zh) 2015-05-20
HUE038955T2 (hu) 2018-12-28
US20230212303A1 (en) 2023-07-06
EP1692182A2 (fr) 2006-08-23
LT2380911T (lt) 2018-07-10
NO20171989A1 (no) 2006-08-03
HK1213574A1 (zh) 2016-07-08
HK1167682A1 (en) 2012-12-07
IL235172A0 (en) 2014-11-30
US8883980B2 (en) 2014-11-11
CY2015001I2 (el) 2016-06-22
MA31040B1 (fr) 2010-01-04
TR201809892T4 (tr) 2018-07-23
JP6235521B2 (ja) 2017-11-22
CN102373214B (zh) 2014-07-09
ES2672640T3 (es) 2018-06-15
NO20062289L (no) 2006-08-03
NL300801I2 (nl) 2017-09-19
US20160075793A1 (en) 2016-03-17
US9296820B2 (en) 2016-03-29
FR15C0076I1 (fr) 2016-01-01
CY1118719T1 (el) 2017-07-12
KR101220691B1 (ko) 2013-01-14
TR201903329T4 (tr) 2019-04-22
EA201100128A1 (ru) 2011-06-30

Similar Documents

Publication Publication Date Title
HRP20190333T1 (hr) Cd20 protutijela s povećanim afinitetom vezanja fc-receptora i povećanom efektorskom funkcijom