BR112016018980A2 - método de tratamento de um distúrbio, anticorpo multiespecífico, ácido nucleico isolado, célula hospedeira, métodos de produzir um anticorpo, de produção de uma metade de anticorpo ou de um anticorpo multiespecífico e de produção de um anticorpo multiespecífico, imunoconjugado e formulação farmacêutica - Google Patents
método de tratamento de um distúrbio, anticorpo multiespecífico, ácido nucleico isolado, célula hospedeira, métodos de produzir um anticorpo, de produção de uma metade de anticorpo ou de um anticorpo multiespecífico e de produção de um anticorpo multiespecífico, imunoconjugado e formulação farmacêuticaInfo
- Publication number
- BR112016018980A2 BR112016018980A2 BR112016018980A BR112016018980A BR112016018980A2 BR 112016018980 A2 BR112016018980 A2 BR 112016018980A2 BR 112016018980 A BR112016018980 A BR 112016018980A BR 112016018980 A BR112016018980 A BR 112016018980A BR 112016018980 A2 BR112016018980 A2 BR 112016018980A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody
- producing
- multispecific
- methods
- disorder
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Abstract
a invenção provê anticorpos biespecíficos anti-il-13/il-17, em particular anticorpos anti-il13/il17aa, af e ff e métodos de uso dos mesmos, incluindo, sem limitação, métodos de uso dos anticorpos biespecíficos anti-il-13/il-17 para o tratamento da asma moderada à grave e/ou asma eosinofílica.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461942823P | 2014-02-21 | 2014-02-21 | |
US201461983945P | 2014-04-24 | 2014-04-24 | |
PCT/US2015/017168 WO2015127405A2 (en) | 2014-02-21 | 2015-02-23 | Anti-il-13/il-17 bispecific antibodies and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112016018980A2 true BR112016018980A2 (pt) | 2017-10-10 |
Family
ID=52630502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016018980A BR112016018980A2 (pt) | 2014-02-21 | 2015-02-23 | método de tratamento de um distúrbio, anticorpo multiespecífico, ácido nucleico isolado, célula hospedeira, métodos de produzir um anticorpo, de produção de uma metade de anticorpo ou de um anticorpo multiespecífico e de produção de um anticorpo multiespecífico, imunoconjugado e formulação farmacêutica |
Country Status (19)
Country | Link |
---|---|
US (1) | US20170334985A1 (pt) |
EP (1) | EP3107574A2 (pt) |
JP (1) | JP2017507939A (pt) |
KR (1) | KR20160124165A (pt) |
CN (1) | CN106029693A (pt) |
AU (1) | AU2015218631A1 (pt) |
BR (1) | BR112016018980A2 (pt) |
CA (1) | CA2937556A1 (pt) |
CL (1) | CL2016002088A1 (pt) |
CR (1) | CR20160379A (pt) |
EA (1) | EA201691473A1 (pt) |
IL (1) | IL247002A0 (pt) |
MX (1) | MX2016010729A (pt) |
PE (1) | PE20161171A1 (pt) |
PH (1) | PH12016501547A1 (pt) |
SG (1) | SG11201606870XA (pt) |
TW (1) | TW201615663A (pt) |
UA (1) | UA117608C2 (pt) |
WO (1) | WO2015127405A2 (pt) |
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WO2016073791A1 (en) * | 2014-11-05 | 2016-05-12 | Genentech, Inc. | Methods of producing two chain proteins in bacteria |
JP6770966B2 (ja) | 2014-11-05 | 2020-10-21 | ジェネンテック, インコーポレイテッド | 細菌における2鎖タンパク質の生成方法 |
BR112018003127A2 (pt) * | 2015-08-20 | 2018-09-25 | Genentech Inc | purificação de fkpa e usos do mesmo para produzir polipeptídeos recombinantes |
US20210380711A1 (en) * | 2018-02-27 | 2021-12-09 | Equillium, Inc. | Anti cd6 antibodies for treating severe asthma |
WO2019178645A1 (en) * | 2018-03-23 | 2019-09-26 | Csl Limited | Method of treating asthma |
JP2021131228A (ja) * | 2018-04-27 | 2021-09-09 | 国立大学法人 東京大学 | 難治性喘息の予防又は治療剤をスクリーニングする方法、及び難治性喘息の予防又は治療剤 |
GB201919061D0 (en) | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Multi-specific antibody |
GB201919062D0 (en) * | 2019-12-20 | 2020-02-05 | Ucb Biopharma Sprl | Antibody |
CN116348494A (zh) * | 2020-10-13 | 2023-06-27 | 阿尔米雷尔有限公司 | 双特异性分子和使用其的治疗方法 |
WO2023209568A1 (en) * | 2022-04-26 | 2023-11-02 | Novartis Ag | Multispecific antibodies targeting il-13 and il-18 |
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-
2015
- 2015-02-23 KR KR1020167025491A patent/KR20160124165A/ko unknown
- 2015-02-23 AU AU2015218631A patent/AU2015218631A1/en not_active Abandoned
- 2015-02-23 UA UAA201608853A patent/UA117608C2/uk unknown
- 2015-02-23 CN CN201580009436.XA patent/CN106029693A/zh active Pending
- 2015-02-23 PE PE2016001507A patent/PE20161171A1/es not_active Application Discontinuation
- 2015-02-23 CA CA2937556A patent/CA2937556A1/en not_active Abandoned
- 2015-02-23 MX MX2016010729A patent/MX2016010729A/es unknown
- 2015-02-23 EP EP15708647.1A patent/EP3107574A2/en not_active Withdrawn
- 2015-02-23 JP JP2016553364A patent/JP2017507939A/ja not_active Ceased
- 2015-02-23 CR CR20160379A patent/CR20160379A/es unknown
- 2015-02-23 WO PCT/US2015/017168 patent/WO2015127405A2/en active Application Filing
- 2015-02-23 BR BR112016018980A patent/BR112016018980A2/pt not_active IP Right Cessation
- 2015-02-23 EA EA201691473A patent/EA201691473A1/ru unknown
- 2015-02-23 SG SG11201606870XA patent/SG11201606870XA/en unknown
- 2015-02-24 TW TW104105984A patent/TW201615663A/zh unknown
-
2016
- 2016-07-28 IL IL247002A patent/IL247002A0/en unknown
- 2016-08-04 PH PH12016501547A patent/PH12016501547A1/en unknown
- 2016-08-18 CL CL2016002088A patent/CL2016002088A1/es unknown
-
2017
- 2017-02-23 US US15/441,059 patent/US20170334985A1/en not_active Abandoned
Also Published As
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IL247002A0 (en) | 2016-09-29 |
MX2016010729A (es) | 2016-10-26 |
EA201691473A1 (ru) | 2016-12-30 |
TW201615663A (zh) | 2016-05-01 |
SG11201606870XA (en) | 2016-09-29 |
CL2016002088A1 (es) | 2017-03-24 |
WO2015127405A3 (en) | 2015-10-15 |
JP2017507939A (ja) | 2017-03-23 |
KR20160124165A (ko) | 2016-10-26 |
PH12016501547A1 (en) | 2016-10-03 |
CN106029693A (zh) | 2016-10-12 |
WO2015127405A2 (en) | 2015-08-27 |
CA2937556A1 (en) | 2015-08-27 |
CR20160379A (es) | 2016-10-07 |
US20170334985A1 (en) | 2017-11-23 |
AU2015218631A1 (en) | 2016-08-11 |
UA117608C2 (uk) | 2018-08-27 |
PE20161171A1 (es) | 2016-11-08 |
EP3107574A2 (en) | 2016-12-28 |
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