BR112016015958A2 - Drives de genes guiados pelo rna - Google Patents

Drives de genes guiados pelo rna

Info

Publication number
BR112016015958A2
BR112016015958A2 BR112016015958A BR112016015958A BR112016015958A2 BR 112016015958 A2 BR112016015958 A2 BR 112016015958A2 BR 112016015958 A BR112016015958 A BR 112016015958A BR 112016015958 A BR112016015958 A BR 112016015958A BR 112016015958 A2 BR112016015958 A2 BR 112016015958A2
Authority
BR
Brazil
Prior art keywords
rna
gene drives
guided gene
guided
drives
Prior art date
Application number
BR112016015958A
Other languages
English (en)
Other versions
BR112016015958B1 (pt
Inventor
M Esvelt Kevin
L Smidler Andrea
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of BR112016015958A2 publication Critical patent/BR112016015958A2/pt
Publication of BR112016015958B1 publication Critical patent/BR112016015958B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/905—Stable introduction of foreign DNA into chromosome using homologous recombination in yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Catching Or Destruction (AREA)

Abstract

DRIVES DE GENES GUIADOS PELO RNA. São divulgados drives de gene Caso guiados pelo RNA e método para o uso dos mesmos.
BR112016015958-6A 2014-01-08 2015-01-08 Métodos para alterar uma célula de linhagem germinativa eucariótica de um organismo não humano, não vegetal e para alterar uma célula de linhagem germinativa eucariótica de um organismo não humano em uma pluralidade de genes BR112016015958B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461924735P 2014-01-08 2014-01-08
US61/924,735 2014-01-08
US201462024642P 2014-07-15 2014-07-15
US62/024,642 2014-07-15
PCT/US2015/010550 WO2015105928A1 (en) 2014-01-08 2015-01-08 Rna-guided gene drives

Publications (2)

Publication Number Publication Date
BR112016015958A2 true BR112016015958A2 (pt) 2017-09-19
BR112016015958B1 BR112016015958B1 (pt) 2024-04-16

Family

ID=

Also Published As

Publication number Publication date
SG10201805815YA (en) 2018-08-30
WO2015105928A9 (en) 2015-09-24
AU2015204784A1 (en) 2016-07-21
SG11201605550QA (en) 2016-08-30
JP2017511685A (ja) 2017-04-27
EP3092310B1 (en) 2019-12-25
JP7187508B2 (ja) 2022-12-12
US20160333376A1 (en) 2016-11-17
US10526618B2 (en) 2020-01-07
CA2936312A1 (en) 2015-07-16
AU2021202590A1 (en) 2021-05-27
CN106133141A (zh) 2016-11-16
EP3092310A4 (en) 2017-11-22
AU2015204784B2 (en) 2021-01-28
ZA201604874B (en) 2022-08-31
JP2021003112A (ja) 2021-01-14
EP3092310A1 (en) 2016-11-16
WO2015105928A1 (en) 2015-07-16
JP6747974B2 (ja) 2020-08-26
CN106133141B (zh) 2021-08-20

Similar Documents

Publication Publication Date Title
DK3433369T3 (da) Rna-replikon til varieret og effektiv genekspression
HK1258288A1 (zh) 核酸酶非依賴性靶向基因編輯平台及其用途
BR112018011133A2 (pt) alvos terapêuticos para a correção do gene humano de distrofina por edição de gene e métodos de uso
DK3353299T3 (da) Fremgangsmåder og stoffer til målrettet rna-editering
DK3390631T3 (da) Fremgangsmåder og sammensætninger til t-rna-baseret guide-rna-ekspression
EP3409776A4 (en) ARN UNIQUE ARTIFICIAL GUIDE AND ITS USE
BR112017009728A2 (pt) anticorpos isolados, ácido nucleico isolado, vetor, célula hospedeira, método para produzir o anticorpo, composição, usos de um anticorpo e métodos de tratamento de um distúrbio
EP3310169A4 (en) Methods for modulating rna splicing
BR112017008877A2 (pt) métodos e composições para sequenciamento de ácido nucleico-alvo
DK3341482T3 (da) Kunstige nukleinsyremolekyler
EP3359691A4 (en) DEVICES, SYSTEMS AND METHODS FOR NUCLEIC ACID SEQUENCING
BR112018005779A2 (pt) repressores de htt e usos dos mesmos
EP3186375A4 (en) NEW CAS9 PROTEINS AND GUIDING ELEMENTS FOR DNA TARGETING AND THE GENOME EDITION
AR101845A1 (es) Anticuerpos anti-her2 e inmunoconjugados
EP3298170A4 (en) Methods for generating circular dna from circular rna
EP3450569A4 (en) DNA AMPLIFICATION METHOD
EP3470529A4 (en) METHOD FOR ISOTHERMAL NUCLEIC ACID SELF-REINFORCEMENT
EP3707257A4 (en) METHODS AND COMPOSITIONS FOR CIRCULAR RNA MOLECULES
DK3262066T4 (da) Genterapi
EP3142680A4 (en) Lpa-associated protein and rna expression
WO2014130686A3 (en) Methods and compositions for nanostructure-based nucleic acid sequencing
DK3119886T3 (da) Kopiantalsbevarende RNA-analysefremgangsmåde
ZA202001649B (en) Rna molecules
EP3436590A4 (en) TRANSFERING RNA (TSRNA)
KR20180084747A (ko) Galgt2 유전자 치료 방법 및 물질

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/01/2015, OBSERVADAS AS CONDICOES LEGAIS