BR112023023777A2 - Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo - Google Patents
Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpoInfo
- Publication number
- BR112023023777A2 BR112023023777A2 BR112023023777A BR112023023777A BR112023023777A2 BR 112023023777 A2 BR112023023777 A2 BR 112023023777A2 BR 112023023777 A BR112023023777 A BR 112023023777A BR 112023023777 A BR112023023777 A BR 112023023777A BR 112023023777 A2 BR112023023777 A2 BR 112023023777A2
- Authority
- BR
- Brazil
- Prior art keywords
- isolated
- trem2
- antibodies
- antibody
- human
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000007523 nucleic acids Chemical class 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 title 1
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000000556 agonist Substances 0.000 abstract 2
- 238000003776 cleavage reaction Methods 0.000 abstract 2
- 210000000274 microglia Anatomy 0.000 abstract 2
- 230000002025 microglial effect Effects 0.000 abstract 2
- 230000007017 scission Effects 0.000 abstract 2
- 230000007351 Aβ plaque formation Effects 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 238000005056 compaction Methods 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000010172 mouse model Methods 0.000 abstract 1
- 210000000066 myeloid cell Anatomy 0.000 abstract 1
- 230000000324 neuroprotective effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo. este pedido divulga, inter alia, certos anticorpos que se ligam especificamente ao trem2 humano (receptor desencadeador expresso em células mieloides 2). em algumas realizações, os anticorpos atuam como agonistas de trem2. em algumas realizações, os anticorpos no presente documento se ligam especificamente à região de haste de trem2 humano intacto, sem ligação ao trem2 solúvel, que é o produto da clivagem do trem2 entre os resíduos h157 e s158. em algumas realizações, os anticorpos atuam como agonistas de trem2, ligam-se especificamente à região de haste de trem2 com constantes de dissociação variando de 10 nm a tão baixas quanto 100-500 pm, 10-50 pm ou 1-10 pm, ligam-se especificamente a um trem2 epítopo abrangendo o sítio de clivagem h157-s158 e não se liga ao trem2 solúvel. em algumas realizações, os anticorpos no presente documento também inibem a liberação de trem2 solúvel em um modelo de célula da micróglia humana e in vivo em um modelo de camundongo, diminuem os níveis de trem2 solúvel no plasma, csf e/ou cérebro, aumentam a sobrevida das células da micróglia humana e aumentam a formação e compactação da placa aß em um modelo de micróglia humana (por exemplo, conforme medido pela intensidade aumentada da placa aß e/ou intensidade aumentada da placa x04 na micróglia humana) e, assim, pode fornecer uma série de atividades neuroprotetoras.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163188800P | 2021-05-14 | 2021-05-14 | |
| PCT/US2022/028920 WO2022241082A1 (en) | 2021-05-14 | 2022-05-12 | Agonists of trem2 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023023777A2 true BR112023023777A2 (pt) | 2024-01-30 |
Family
ID=81851381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023023777A BR112023023777A2 (pt) | 2021-05-14 | 2022-05-12 | Anticorpos isolados, composição farmacêutica, ácido nucleico isolado, vetor isolado, célula hospedeira isolada, método para produzir um anticorpo, método para tratar uma condição associada à perda de função de trem2, método para reduzir os níveis de strem2 e uso de um anticorpo |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220389097A1 (pt) |
| EP (1) | EP4337317A1 (pt) |
| JP (1) | JP2024518545A (pt) |
| KR (1) | KR20240007928A (pt) |
| CN (1) | CN117396510A (pt) |
| AR (1) | AR125855A1 (pt) |
| AU (1) | AU2022273303A1 (pt) |
| BR (1) | BR112023023777A2 (pt) |
| CA (1) | CA3219425A1 (pt) |
| TW (1) | TW202306993A (pt) |
| WO (1) | WO2022241082A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019022752A2 (pt) * | 2017-08-03 | 2020-05-19 | Alector Llc | anticorpos anti-trem2 e métodos de uso dos mesmos |
| WO2023164516A1 (en) | 2022-02-23 | 2023-08-31 | Alector Llc | Methods of use of anti-trem2 antibodies |
| WO2024040194A1 (en) | 2022-08-17 | 2024-02-22 | Capstan Therapeutics, Inc. | Conditioning for in vivo immune cell engineering |
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-
2022
- 2022-05-12 BR BR112023023777A patent/BR112023023777A2/pt unknown
- 2022-05-12 CA CA3219425A patent/CA3219425A1/en active Pending
- 2022-05-12 TW TW111117846A patent/TW202306993A/zh unknown
- 2022-05-12 WO PCT/US2022/028920 patent/WO2022241082A1/en active Application Filing
- 2022-05-12 AR ARP220101265A patent/AR125855A1/es unknown
- 2022-05-12 US US17/742,686 patent/US20220389097A1/en active Pending
- 2022-05-12 KR KR1020237042889A patent/KR20240007928A/ko unknown
- 2022-05-12 CN CN202280034832.8A patent/CN117396510A/zh active Pending
- 2022-05-12 EP EP22726361.3A patent/EP4337317A1/en active Pending
- 2022-05-12 JP JP2023570146A patent/JP2024518545A/ja active Pending
- 2022-05-12 AU AU2022273303A patent/AU2022273303A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP4337317A1 (en) | 2024-03-20 |
| WO2022241082A1 (en) | 2022-11-17 |
| US20220389097A1 (en) | 2022-12-08 |
| JP2024518545A (ja) | 2024-05-01 |
| KR20240007928A (ko) | 2024-01-17 |
| AU2022273303A1 (en) | 2023-11-02 |
| CA3219425A1 (en) | 2022-11-17 |
| TW202306993A (zh) | 2023-02-16 |
| AR125855A1 (es) | 2023-08-16 |
| CN117396510A (zh) | 2024-01-12 |
| AU2022273303A9 (en) | 2023-11-16 |
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