MA55025A - Anticorps anti-trem2 et leurs procédés d'utilisation - Google Patents

Anticorps anti-trem2 et leurs procédés d'utilisation

Info

Publication number
MA55025A
MA55025A MA055025A MA55025A MA55025A MA 55025 A MA55025 A MA 55025A MA 055025 A MA055025 A MA 055025A MA 55025 A MA55025 A MA 55025A MA 55025 A MA55025 A MA 55025A
Authority
MA
Morocco
Prior art keywords
methods
trem2 antibodies
trem2
antibodies
Prior art date
Application number
MA055025A
Other languages
English (en)
Inventor
Mark S Dennis
Sherie Duncan
Kathleen Lisaingo
Kathryn M Monroe
Joshua I Park
Rachel Prorok
Ju Shi
Ankita Srivastava
Lengerich Bettina Van
Riley Walsh
Original Assignee
Denali Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of MA55025A publication Critical patent/MA55025A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA055025A 2019-02-20 2020-02-20 Anticorps anti-trem2 et leurs procédés d'utilisation MA55025A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962808141P 2019-02-20 2019-02-20

Publications (1)

Publication Number Publication Date
MA55025A true MA55025A (fr) 2021-12-29

Family

ID=69844940

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055025A MA55025A (fr) 2019-02-20 2020-02-20 Anticorps anti-trem2 et leurs procédés d'utilisation

Country Status (20)

Country Link
US (2) US20220119522A1 (fr)
EP (1) EP3927743A1 (fr)
JP (1) JP7543290B2 (fr)
KR (1) KR20210135518A (fr)
CN (1) CN113614110A (fr)
AR (1) AR118144A1 (fr)
AU (1) AU2020226754A1 (fr)
BR (1) BR112021015656A2 (fr)
CA (1) CA3130086A1 (fr)
CL (1) CL2021002206A1 (fr)
CO (1) CO2021012230A2 (fr)
EA (1) EA202192294A1 (fr)
EC (1) ECSP21069105A (fr)
IL (1) IL285651A (fr)
MA (1) MA55025A (fr)
MX (1) MX2021009722A (fr)
PE (1) PE20211979A1 (fr)
SG (1) SG11202108734VA (fr)
TW (1) TW202045543A (fr)
WO (2) WO2020172457A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
BR112022013756A2 (pt) 2020-01-13 2022-10-11 Denali Therapeutics Inc Anticorpos anti-trem2 e métodos de uso dos mesmos
CA3219425A1 (fr) * 2021-05-14 2022-11-17 Genentech, Inc. Agonistes de trem2
CN118765204A (zh) 2022-02-23 2024-10-11 艾利妥 抗trem2抗体的使用方法
WO2023192288A1 (fr) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Molécules de liaison anti-trem2 monovalentes et leurs procédés d'utilisation
WO2023192282A1 (fr) 2022-03-28 2023-10-05 Denali Therapeutics Inc. Méthodes de traitement de l'hypométabolisme du glucose cérébral
WO2024160736A1 (fr) 2023-01-30 2024-08-08 Isar Bioscience Gmbh Anticorps anti-trem2 humain pour le traitement de troubles neurodégénératifs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10087408B2 (en) 2010-07-07 2018-10-02 The University Of British Columbia System and method for microfluidic cell culture
US9188593B2 (en) 2010-07-16 2015-11-17 The University Of British Columbia Methods for assaying cellular binding interactions
EP4066859A1 (fr) 2014-08-08 2022-10-05 Alector LLC Anticorps anti-trem2 et leurs procédés d'utilisation
EP3277305B1 (fr) * 2015-03-31 2021-07-21 F. Hoffmann-La Roche AG Molécules de liaison d'antigène comprenant un trimère de ligand de la famille tnf
WO2017058866A1 (fr) * 2015-09-28 2017-04-06 Precision Immune, Inc. Anticorps anti-trem2 et leurs utilisations
JP2018537956A (ja) 2015-10-06 2018-12-27 アレクトル エルエルシー 抗trem2抗体及びその使用方法
JOP20190248A1 (ar) 2017-04-21 2019-10-20 Amgen Inc بروتينات ربط مولد ضد trem2 واستخداماته
TW202342547A (zh) 2017-08-03 2023-11-01 美商阿列克特有限責任公司 抗trem2抗體及其使用方法

Also Published As

Publication number Publication date
JP2022520868A (ja) 2022-04-01
TW202045543A (zh) 2020-12-16
AR118144A1 (es) 2021-09-22
PE20211979A1 (es) 2021-10-05
JP7543290B2 (ja) 2024-09-02
CO2021012230A2 (es) 2021-09-30
IL285651A (en) 2021-09-30
CA3130086A1 (fr) 2020-08-27
EP3927743A1 (fr) 2021-12-29
CN113614110A (zh) 2021-11-05
BR112021015656A2 (pt) 2021-10-05
CL2021002206A1 (es) 2022-04-22
SG11202108734VA (en) 2021-09-29
MX2021009722A (es) 2021-09-14
WO2020172450A1 (fr) 2020-08-27
WO2020172457A1 (fr) 2020-08-27
KR20210135518A (ko) 2021-11-15
EA202192294A1 (ru) 2021-12-24
AU2020226754A1 (en) 2021-09-16
US20220073609A1 (en) 2022-03-10
US20220119522A1 (en) 2022-04-21
ECSP21069105A (es) 2021-11-18

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