WO2000010007A2 - Dispositifs et procedes d'analyse de solutes non ioniques - Google Patents

Dispositifs et procedes d'analyse de solutes non ioniques Download PDF

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Publication number
WO2000010007A2
WO2000010007A2 PCT/US1999/018615 US9918615W WO0010007A2 WO 2000010007 A2 WO2000010007 A2 WO 2000010007A2 US 9918615 W US9918615 W US 9918615W WO 0010007 A2 WO0010007 A2 WO 0010007A2
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WO
WIPO (PCT)
Prior art keywords
poly
sensor
acid
vinyl
concentration
Prior art date
Application number
PCT/US1999/018615
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English (en)
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WO2000010007A3 (fr
WO2000010007A9 (fr
Inventor
Frances H. Arnold
Alan S. Michaels
Weigong Zheng
Original Assignee
California Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Institute Of Technology filed Critical California Institute Of Technology
Priority to AU55652/99A priority Critical patent/AU5565299A/en
Publication of WO2000010007A2 publication Critical patent/WO2000010007A2/fr
Publication of WO2000010007A9 publication Critical patent/WO2000010007A9/fr
Publication of WO2000010007A3 publication Critical patent/WO2000010007A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des dispositifs et procédés de détection et de contrôle de la concentration, du niveau ou de la quantité d'une molécule cible dans une solution. Plus particulièrement, l'invention concerne des détecteurs évaluant des changements de conductivité produits par la réaction d'une molécule cible avec une composition de détection. L'invention est particulièrement appropriée pour déterminer la concentration de composés d'hydrates de carbone dans une solution, tels que des composés diols, de préférence des diols cis biologiquement importants tels que différents sucres, y compris le glucose. L'invention concerne également des détecteurs permettant de déterminer la quantité totale ou relative d'une molécule cible dans un échantillon, en particulier un échantillon biologique tel que le sang, l'urine ou d'autres liquides organiques. Un détecteur stratifié selon l'invention comprend une composition de détection appliquée sur une électrode métallique telle qu'une électrode en or interdigitée ou un support non conducteur. La composition de détection et l'électrode sont de préférence entourées d'une membrane bipolaire. Dans un mode de réalisation préférée, la composition de détection est formée d'un mélange de polymère d'acide borique et d'une matrice d'hydrogel non ionogène.
PCT/US1999/018615 1998-08-17 1999-08-16 Dispositifs et procedes d'analyse de solutes non ioniques WO2000010007A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55652/99A AU5565299A (en) 1998-08-17 1999-08-16 Devices and methods for analysis of non-ionic solutes

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US9673998P 1998-08-17 1998-08-17
US60/096,739 1998-08-17
US30125299A 1999-04-28 1999-04-28
US09/301,252 1999-04-28

Publications (3)

Publication Number Publication Date
WO2000010007A2 true WO2000010007A2 (fr) 2000-02-24
WO2000010007A9 WO2000010007A9 (fr) 2000-07-06
WO2000010007A3 WO2000010007A3 (fr) 2000-08-17

Family

ID=26792028

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/018615 WO2000010007A2 (fr) 1998-08-17 1999-08-16 Dispositifs et procedes d'analyse de solutes non ioniques

Country Status (2)

Country Link
AU (1) AU5565299A (fr)
WO (1) WO2000010007A2 (fr)

Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU750815B2 (en) * 1999-08-20 2002-07-25 Levine, Robert A. Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
WO2002092722A1 (fr) * 2001-03-28 2002-11-21 3M Innovative Properties Company Procede de transfert de molecules sur un lamelle de films
US6681127B2 (en) 1999-08-26 2004-01-20 Novartis Ag Ocular analyte sensor
US7041063B2 (en) 1996-09-04 2006-05-09 Marcio Marc Abreu Noninvasive measurement of chemical substances
US7187960B2 (en) 2002-04-22 2007-03-06 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
WO2008107271A1 (fr) * 2007-03-05 2008-09-12 Mip Technologies Ab Polymères à empreintes moléculaires
WO2008038246A3 (fr) * 2006-09-29 2008-10-09 Koninkl Philips Electronics Nv Capteur de seuil miniaturisé
WO2008157325A2 (fr) * 2007-06-15 2008-12-24 Charles Stark Draper Laboratory, Inc. Dispositifs, systèmes, et procédés pour mesurer le glucose
US20100168356A1 (en) * 2008-12-30 2010-07-01 Yu-Chin Lai Biomedical Devices
US7854159B2 (en) 2006-06-08 2010-12-21 Technische Universität Dresden Sensor and methods for measuring of concentrations of components in a liquid
US20120009126A1 (en) * 2000-12-05 2012-01-12 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US8181531B2 (en) 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US8706425B2 (en) 2011-07-20 2014-04-22 Veolia Water Solutions & Technologies Support Method for validation of polymer aqueous solutions concentration and activation in water treatment applications and polymer make-up unit therefor
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8883980B2 (en) 2003-11-05 2014-11-11 Roche Glycart Ag Antigen binding molecules with increased Fc receptor binding affinity and effector function
US9011670B2 (en) 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
CN105189614A (zh) * 2013-03-01 2015-12-23 加州理工学院 用硝基苯硼酸组合物稳定的纳米粒子
US20160109370A1 (en) * 2014-10-21 2016-04-21 Lg Electronics Inc. Sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same
US9445767B2 (en) 2005-10-24 2016-09-20 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
EP3098604A1 (fr) * 2015-05-22 2016-11-30 Seiko Epson Corporation Gel pour capteur et un tel capteur
WO2017030934A1 (fr) * 2015-08-14 2017-02-23 Razzberry Inc. Électrodes à l'état solide, procédés de fabrication et méthodes d'utilisation en détection
CN106662549A (zh) * 2014-06-23 2017-05-10 国立大学法人东京大学 采样单元和生物传感器
US9848815B2 (en) 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US10155051B2 (en) 2008-08-13 2018-12-18 California Institute Of Technology Carrier nanoparticles and related compositions, methods and systems
US10166291B2 (en) 2013-03-01 2019-01-01 California Institute Of Technology Targeted nanoparticles
US10227063B2 (en) 2004-02-26 2019-03-12 Geelux Holdings, Ltd. Method and apparatus for biological evaluation
US10238847B2 (en) 2014-01-22 2019-03-26 Geelux Holdings, Ltd. Devices and methods for transdermal drug delivery
US10251776B2 (en) 2014-01-10 2019-04-09 Geelux Holding, Ltd. Devices configured to monitor biological parameters, and to provide treatment, at an Abreu brain thermal tunnel
US10335040B2 (en) 2014-01-10 2019-07-02 Geelux Holdings, Ltd. Device for measuring the infrared output of the Abreu brain thermal tunnel
US10717825B2 (en) 2015-07-01 2020-07-21 California Instite of Technology Cationic mucic acid polymer-based delivery system
CN112782251A (zh) * 2021-01-07 2021-05-11 安徽大学 一种定量检测重铬酸钾的方法
CN112840210A (zh) * 2018-09-06 2021-05-25 澳科环球有限公司 用于确定分析物浓度的系统、传感器和方法
US11497405B2 (en) 2013-10-11 2022-11-15 Brain Tunnelgenix Technologies Corp. Method and apparatus for biological evaluation
US11872018B2 (en) 2015-03-10 2024-01-16 Brain Tunnelgenix Technologies Corp. Devices, apparatuses, systems, and methods for measuring temperature of an ABTT terminus
WO2023288016A3 (fr) * 2021-07-16 2024-04-04 Proton Intelligence Inc. Capteur ayant une membrane profilée

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569126B2 (en) 2004-06-18 2009-08-04 Roche Diagnostics Operations, Inc. System and method for quality assurance of a biosensor test strip

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GB2194843A (en) * 1986-09-08 1988-03-16 Cambridge Life Sciences Enzyme electrode membrane and method of making same
JPH04124145A (ja) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd 糖応答性高分子複合体
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EP0596700A1 (fr) * 1992-11-03 1994-05-11 Hewlett-Packard Company Méthode de détection de cis-diol et supports solides
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JPH04124145A (ja) * 1990-09-13 1992-04-24 Nippon Oil & Fats Co Ltd 糖応答性高分子複合体
EP0539625A1 (fr) * 1991-10-28 1993-05-05 Dräger Medical Electronics B.V. Capteur électrochimique pour mesurer la teneur en glucose des fluides
JPH05262779A (ja) * 1992-03-18 1993-10-12 Nippon Oil & Fats Co Ltd ボロン酸基含有モノマーおよびそのポリマー
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US5594111A (en) * 1994-01-28 1997-01-14 Prolinx, Inc. Phenylboronic acid complexes for bioconjugate preparation
DE4437274A1 (de) * 1994-10-18 1996-04-25 Inst Chemo Biosensorik Analytselektiver Sensor
WO1997033177A1 (fr) * 1996-03-04 1997-09-12 California Institute Of Technology Detecteurs de sucres et d'autres analytes se liant a des metaux

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PATENT ABSTRACTS OF JAPAN vol. 016, no. 383 (C-0974), 17 August 1992 (1992-08-17) & JP 04 124145 A (NIPPON OIL & FATS CO LTD), 24 April 1992 (1992-04-24) *
PATENT ABSTRACTS OF JAPAN vol. 018, no. 032 (C-1154), 18 January 1994 (1994-01-18) & JP 05 262779 A (NIPPON OIL & FATS CO LTD), 12 October 1993 (1993-10-12) *

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US7756559B2 (en) 1996-09-04 2010-07-13 Marcio Marc Abreu Device for generating a detectable signal based upon antibody/antigen interaction
US8774885B2 (en) 1996-09-04 2014-07-08 Geelux Holdings, Ltd. Device for generating a detectable signal based upon concentration of at least one substance
US7041063B2 (en) 1996-09-04 2006-05-09 Marcio Marc Abreu Noninvasive measurement of chemical substances
US7809417B2 (en) 1996-09-04 2010-10-05 Marcio Marc Abreu Contact lens for collecting tears and detecting analytes for determining health status, ovulation detection, and diabetes screening
AU750815B2 (en) * 1999-08-20 2002-07-25 Levine, Robert A. Method and assembly for separating formed constituents from a liquid constituent in a complex biologic fluid sample
US6681127B2 (en) 1999-08-26 2004-01-20 Novartis Ag Ocular analyte sensor
US6850786B2 (en) 1999-08-26 2005-02-01 Novartis Ag Ocular analyte sensor
US20120009126A1 (en) * 2000-12-05 2012-01-12 The Regents Of The University Of California Optical determination of glucose utilizing boronic acid adducts
US7403805B2 (en) 2001-02-23 2008-07-22 Marcio Marc Abreu Apparatus and method for noninvasive measurement of analytes from the conjunctiva using mid-infrared radiation
US8914089B2 (en) 2001-02-23 2014-12-16 Geelux Holdings, Ltd. Noninvasive measurement of chemical substances
WO2002092722A1 (fr) * 2001-03-28 2002-11-21 3M Innovative Properties Company Procede de transfert de molecules sur un lamelle de films
US9398856B2 (en) 2002-04-22 2016-07-26 Geelux Holdings, Ltd. Thermal imaging system
US9301719B2 (en) 2002-04-22 2016-04-05 Geelux Holding, Ltd. Apparatus and method for measuring biologic parameters
US11045092B2 (en) 2002-04-22 2021-06-29 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9011349B2 (en) 2002-04-22 2015-04-21 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US10729371B2 (en) 2002-04-22 2020-08-04 Geelux Holdings Ltd. Apparatus and method for measuring biologic parameters
US10123732B2 (en) 2002-04-22 2018-11-13 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US7187960B2 (en) 2002-04-22 2007-03-06 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US10052030B2 (en) 2002-04-22 2018-08-21 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9848815B2 (en) 2002-04-22 2017-12-26 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8721562B2 (en) 2002-04-22 2014-05-13 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US9408572B2 (en) 2002-04-22 2016-08-09 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8849379B2 (en) 2002-04-22 2014-09-30 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US8328420B2 (en) 2003-04-22 2012-12-11 Marcio Marc Abreu Apparatus and method for measuring biologic parameters
US8883980B2 (en) 2003-11-05 2014-11-11 Roche Glycart Ag Antigen binding molecules with increased Fc receptor binding affinity and effector function
US9296820B2 (en) 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
US10227063B2 (en) 2004-02-26 2019-03-12 Geelux Holdings, Ltd. Method and apparatus for biological evaluation
US9445767B2 (en) 2005-10-24 2016-09-20 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US10448890B2 (en) 2005-10-24 2019-10-22 Geelux Holdings, Ltd. Apparatus and method for measuring biologic parameters
US7854159B2 (en) 2006-06-08 2010-12-21 Technische Universität Dresden Sensor and methods for measuring of concentrations of components in a liquid
US9227011B2 (en) 2006-09-29 2016-01-05 MEDIMETRICS Personalized Drug Delivery B.V. Miniaturized threshold sensor
WO2008038246A3 (fr) * 2006-09-29 2008-10-09 Koninkl Philips Electronics Nv Capteur de seuil miniaturisé
US8252876B2 (en) 2007-03-05 2012-08-28 Biotage Ab Imprinted polymers
WO2008107271A1 (fr) * 2007-03-05 2008-09-12 Mip Technologies Ab Polymères à empreintes moléculaires
AU2008224044B2 (en) * 2007-03-05 2013-05-02 Biotage Ab Imprinted polymers
WO2008157325A3 (fr) * 2007-06-15 2009-03-05 Draper Lab Charles S Dispositifs, systèmes, et procédés pour mesurer le glucose
WO2008157325A2 (fr) * 2007-06-15 2008-12-24 Charles Stark Draper Laboratory, Inc. Dispositifs, systèmes, et procédés pour mesurer le glucose
US8181531B2 (en) 2008-06-27 2012-05-22 Edwin Carlen Accessible stress-based electrostatic monitoring of chemical reactions and binding
US10342879B2 (en) 2008-08-13 2019-07-09 California Institute Of Technology Carrier nanoparticles and related compositions, methods and systems
US10155051B2 (en) 2008-08-13 2018-12-18 California Institute Of Technology Carrier nanoparticles and related compositions, methods and systems
US9011670B2 (en) 2008-08-14 2015-04-21 The Charles Stark Draper Laboratory, Inc. Three-dimensional metal ion sensor arrays on printed circuit boards
US20100168356A1 (en) * 2008-12-30 2010-07-01 Yu-Chin Lai Biomedical Devices
US8706425B2 (en) 2011-07-20 2014-04-22 Veolia Water Solutions & Technologies Support Method for validation of polymer aqueous solutions concentration and activation in water treatment applications and polymer make-up unit therefor
CN105189614B (zh) * 2013-03-01 2019-04-12 加州理工学院 用硝基苯硼酸组合物稳定的纳米粒子
US10166291B2 (en) 2013-03-01 2019-01-01 California Institute Of Technology Targeted nanoparticles
US11285212B2 (en) 2013-03-01 2022-03-29 California Institute Of Technology Targeted nanoparticles
CN105189614A (zh) * 2013-03-01 2015-12-23 加州理工学院 用硝基苯硼酸组合物稳定的纳米粒子
US11497405B2 (en) 2013-10-11 2022-11-15 Brain Tunnelgenix Technologies Corp. Method and apparatus for biological evaluation
US10335040B2 (en) 2014-01-10 2019-07-02 Geelux Holdings, Ltd. Device for measuring the infrared output of the Abreu brain thermal tunnel
US10251776B2 (en) 2014-01-10 2019-04-09 Geelux Holding, Ltd. Devices configured to monitor biological parameters, and to provide treatment, at an Abreu brain thermal tunnel
US10383525B2 (en) 2014-01-10 2019-08-20 Geelux Holdings, Ltd. Device for measuring the infrared output of the Abreu brain thermal tunnel
US11786394B2 (en) 2014-01-10 2023-10-17 Brain Tunnelgenix Technologies Corp. Devices configured to monitor biological parameters, and to provide treatment, at an Abreu brain thermal tunnel
US11963742B2 (en) 2014-01-10 2024-04-23 Brain Tunnelgenix Technologies Corp. Device for measuring the infrared output of the Abreu brain thermal tunnel
US10238847B2 (en) 2014-01-22 2019-03-26 Geelux Holdings, Ltd. Devices and methods for transdermal drug delivery
US11331461B2 (en) 2014-01-22 2022-05-17 Brain Tunnelgenix Technologies Corp. Devices configured to provide treatment at an Abreu brain thermal tunnel
CN106662549A (zh) * 2014-06-23 2017-05-10 国立大学法人东京大学 采样单元和生物传感器
CN106662549B (zh) * 2014-06-23 2019-10-22 国立大学法人东京大学 采样单元和生物传感器
US9897920B2 (en) * 2014-10-21 2018-02-20 Lg Electronics Inc. Sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same
US20160109370A1 (en) * 2014-10-21 2016-04-21 Lg Electronics Inc. Sensor for detecting saccharide and manufacturing method thereof and detection method of glycated hemoglobin using the same
US11872018B2 (en) 2015-03-10 2024-01-16 Brain Tunnelgenix Technologies Corp. Devices, apparatuses, systems, and methods for measuring temperature of an ABTT terminus
EP3098604A1 (fr) * 2015-05-22 2016-11-30 Seiko Epson Corporation Gel pour capteur et un tel capteur
US11041050B2 (en) 2015-07-01 2021-06-22 California Institute Of Technology Cationic mucic acid polymer-based delivery systems
US10717825B2 (en) 2015-07-01 2020-07-21 California Instite of Technology Cationic mucic acid polymer-based delivery system
WO2017030934A1 (fr) * 2015-08-14 2017-02-23 Razzberry Inc. Électrodes à l'état solide, procédés de fabrication et méthodes d'utilisation en détection
CN112840210A (zh) * 2018-09-06 2021-05-25 澳科环球有限公司 用于确定分析物浓度的系统、传感器和方法
CN112782251B (zh) * 2021-01-07 2022-03-25 安徽大学 一种定量检测重铬酸钾的方法
CN112782251A (zh) * 2021-01-07 2021-05-11 安徽大学 一种定量检测重铬酸钾的方法
WO2023288016A3 (fr) * 2021-07-16 2024-04-04 Proton Intelligence Inc. Capteur ayant une membrane profilée

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Publication number Publication date
WO2000010007A3 (fr) 2000-08-17
AU5565299A (en) 2000-03-06
WO2000010007A9 (fr) 2000-07-06

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