AR049292A1 - Metodo para tratar lupus con un anticuerpo cd20 - Google Patents

Metodo para tratar lupus con un anticuerpo cd20

Info

Publication number
AR049292A1
AR049292A1 ARP050102269A ARP050102269A AR049292A1 AR 049292 A1 AR049292 A1 AR 049292A1 AR P050102269 A ARP050102269 A AR P050102269A AR P050102269 A ARP050102269 A AR P050102269A AR 049292 A1 AR049292 A1 AR 049292A1
Authority
AR
Argentina
Prior art keywords
antibody
exposure
medicament
subject
agent
Prior art date
Application number
ARP050102269A
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English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35503635&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR049292(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR049292A1 publication Critical patent/AR049292A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

La presente trata de un método para tratar lupus con un anticuerpo CD20 y un artículo de manufactura para el mismo. Reivindicacion 1: Un método para el tratamiento de lupus en un sujeto que comprende administrar una cantidad eficaz de un anticuerpo CD20 al sujeto para proveer una exposicion inicial al anticuerpo de aproximadamente 0,5 a 4 gramos seguido de una segunda exposicion al anticuerpo de aproximadamente 0,5 a 4 gramos, donde la segunda exposicion no se provee hasta desde aproximadamente 16 a 54 semanas desde la exposicion inicial y cada una de las exposiciones a anticuerpo se provee al sujeto como una dosis unica o como dos o tres dosis separadas de anticuerpo. Reivindicacion 12: El método de cualquiera de las reivindicaciones 1-11, donde se administra un segundo medicamento en una cantidad eficaz con una exposicion al anticuerpo donde el anticuerpo CD20 es un primer medicamento. Reivindicacion 14: El método de la reivindicacion 12 o 13, donde el segundo medicamento es un agente quimioterapéutico, un agente inmunosupresor, un agente citotoxico, un antagonista de integrina, un antagonista de citoquina o una hormona. Reivindicacion 15: El método de la reivindicacion 14, donde se administra un corticoesteroide, metotrexato, ciclofosfamida, azatioprina, micofenolato mofetil o 6-mercaptopurina. Reivindicacion 21: El método de cualquiera de las reivindicaciones 1-20, donde el anticuerpo es rituximab o un 2H7 humanizado que comprende la secuencia de dominio variable en las SEC ID NOS: 2 y 8 o un anticuerpo que comprende las secuencias de dominio variable en las SEC ID NOS: 18 y 19. Reivindicacion 25: El artículo de la reivindicacion 24, donde el segundo medicamento es un agente quimioterapéutico, un agente inmunosupresor, un agente citotoxico, un antagonista de integrina, un antagonista de citoquina o una hormona.
ARP050102269A 2004-06-04 2005-06-02 Metodo para tratar lupus con un anticuerpo cd20 AR049292A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57723504P 2004-06-04 2004-06-04
US61799704P 2004-10-11 2004-10-11

Publications (1)

Publication Number Publication Date
AR049292A1 true AR049292A1 (es) 2006-07-12

Family

ID=35503635

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050102269A AR049292A1 (es) 2004-06-04 2005-06-02 Metodo para tratar lupus con un anticuerpo cd20

Country Status (16)

Country Link
US (3) US20060024295A1 (es)
EP (1) EP1765400A2 (es)
JP (1) JP2008501706A (es)
AR (1) AR049292A1 (es)
AU (1) AU2005251764A1 (es)
BR (1) BRPI0510885A (es)
CA (1) CA2568336A1 (es)
DO (1) DOP2005000108A (es)
IL (1) IL179325A0 (es)
MX (1) MXPA06014067A (es)
PA (1) PA8635501A1 (es)
PE (1) PE20060688A1 (es)
RU (1) RU2396980C2 (es)
SV (1) SV2006002131A (es)
TW (1) TW200608994A (es)
WO (1) WO2005120437A2 (es)

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AU2005251764A1 (en) 2005-12-22
IL179325A0 (en) 2007-03-08
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PA8635501A1 (es) 2006-06-02
RU2396980C2 (ru) 2010-08-20
SV2006002131A (es) 2006-01-26
US20100303810A1 (en) 2010-12-02
US20070025988A1 (en) 2007-02-01
PE20060688A1 (es) 2006-09-23
EP1765400A2 (en) 2007-03-28
MXPA06014067A (es) 2007-02-15
TW200608994A (en) 2006-03-16
RU2006146927A (ru) 2008-08-10
BRPI0510885A (pt) 2007-12-26
JP2008501706A (ja) 2008-01-24
US20060024295A1 (en) 2006-02-02
WO2005120437A2 (en) 2005-12-22
CA2568336A1 (en) 2005-12-22

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