CA2894688A1 - Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells - Google Patents

Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells Download PDF

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Publication number
CA2894688A1
CA2894688A1 CA2894688A CA2894688A CA2894688A1 CA 2894688 A1 CA2894688 A1 CA 2894688A1 CA 2894688 A CA2894688 A CA 2894688A CA 2894688 A CA2894688 A CA 2894688A CA 2894688 A1 CA2894688 A1 CA 2894688A1
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Prior art keywords
sequence
crispr
cell
expression
target
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CA2894688A
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English (en)
French (fr)
Inventor
Feng Zhang
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Massachusetts Institute of Technology
Broad Institute Inc
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Massachusetts Institute of Technology
Broad Institute Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50441380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2894688(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology, Broad Institute Inc filed Critical Massachusetts Institute of Technology
Publication of CA2894688A1 publication Critical patent/CA2894688A1/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
    • C12N9/226—Class 2 CAS enzyme complex, e.g. single CAS protein
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • A61K38/46—Hydrolases (3)
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    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

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  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmacology & Pharmacy (AREA)
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CA2894688A 2012-12-12 2013-12-12 Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells Pending CA2894688A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261736527P 2012-12-12 2012-12-12
US61/736,527 2012-12-12
US201361748427P 2013-01-02 2013-01-02
US61/748,427 2013-01-02
US201361791409P 2013-03-15 2013-03-15
US61/791,409 2013-03-15
US201361835931P 2013-06-17 2013-06-17
US61/835,931 2013-06-17
US201361842322P 2013-07-02 2013-07-02
US61/842,322 2013-07-02
US14/054,414 US8697359B1 (en) 2012-12-12 2013-10-15 CRISPR-Cas systems and methods for altering expression of gene products
US14/054,414 2013-10-15
PCT/US2013/074743 WO2014093661A2 (en) 2012-12-12 2013-12-12 Crispr-cas systems and methods for altering expression of gene products

Publications (1)

Publication Number Publication Date
CA2894688A1 true CA2894688A1 (en) 2014-06-19

Family

ID=50441380

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Application Number Title Priority Date Filing Date
CA2894688A Pending CA2894688A1 (en) 2012-12-12 2013-12-12 Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells

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US (8) US8697359B1 (enExample)
EP (2) EP2998400A1 (enExample)
JP (6) JP6545621B2 (enExample)
KR (1) KR20150107739A (enExample)
CN (4) CN106480080B (enExample)
AU (5) AU2013359238B2 (enExample)
BR (1) BR112015013785A2 (enExample)
CA (1) CA2894688A1 (enExample)
DK (1) DK2764103T3 (enExample)
ES (1) ES2552535T3 (enExample)
HK (1) HK1216259A1 (enExample)
PL (1) PL2764103T3 (enExample)
PT (1) PT2764103E (enExample)
RU (1) RU2687451C1 (enExample)
WO (1) WO2014093661A2 (enExample)

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