AU2013359238B2 - CRISPR-Cas systems and methods for altering expression of gene products - Google Patents

CRISPR-Cas systems and methods for altering expression of gene products

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Publication number
AU2013359238B2
AU2013359238B2 AU2013359238A AU2013359238A AU2013359238B2 AU 2013359238 B2 AU2013359238 B2 AU 2013359238B2 AU 2013359238 A AU2013359238 A AU 2013359238A AU 2013359238 A AU2013359238 A AU 2013359238A AU 2013359238 B2 AU2013359238 B2 AU 2013359238B2
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AU
Australia
Prior art keywords
sequence
crispr
cell
expression
target
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Active
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AU2013359238A
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English (en)
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AU2013359238A1 (en
Inventor
Feng Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Massachusetts Institute of Technology
Broad Institute Inc
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Massachusetts Institute of Technology
Broad Institute Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50441380&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2013359238(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Massachusetts Institute of Technology, Broad Institute Inc filed Critical Massachusetts Institute of Technology
Publication of AU2013359238A1 publication Critical patent/AU2013359238A1/en
Application granted granted Critical
Publication of AU2013359238B2 publication Critical patent/AU2013359238B2/en
Priority to AU2016244244A priority Critical patent/AU2016244244B2/en
Priority to AU2019201608A priority patent/AU2019201608B2/en
Priority to AU2022201052A priority patent/AU2022201052B2/en
Priority to AU2025202729A priority patent/AU2025202729A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/46—Hydrolases (3)
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
    • C—CHEMISTRY; METALLURGY
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea

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AU2013359238A 2012-12-12 2013-12-12 CRISPR-Cas systems and methods for altering expression of gene products Active AU2013359238B2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2016244244A AU2016244244B2 (en) 2012-12-12 2016-10-12 CRISPR-Cas systems and methods for altering expression of gene products
AU2019201608A AU2019201608B2 (en) 2012-12-12 2019-03-08 CRISPR-Cas systems and methods for altering expression of gene products
AU2022201052A AU2022201052B2 (en) 2012-12-12 2022-02-17 CRISPR-Cas systems and methods for altering expression of gene products
AU2025202729A AU2025202729A1 (en) 2012-12-12 2025-04-17 CRISPR-Cas systems and methods for altering expression of gene products

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201261736527P 2012-12-12 2012-12-12
US61/736,527 2012-12-12
US201361748427P 2013-01-02 2013-01-02
US61/748,427 2013-01-02
US201361791409P 2013-03-15 2013-03-15
US61/791,409 2013-03-15
US201361835931P 2013-06-17 2013-06-17
US61/835,931 2013-06-17
US201361842322P 2013-07-02 2013-07-02
US61/842,322 2013-07-02
US14/054,414 2013-10-15
US14/054,414 US8697359B1 (en) 2012-12-12 2013-10-15 CRISPR-Cas systems and methods for altering expression of gene products
PCT/US2013/074743 WO2014093661A2 (en) 2012-12-12 2013-12-12 Crispr-cas systems and methods for altering expression of gene products

Related Child Applications (1)

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AU2016244244A Division AU2016244244B2 (en) 2012-12-12 2016-10-12 CRISPR-Cas systems and methods for altering expression of gene products

Publications (2)

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AU2013359238A1 AU2013359238A1 (en) 2015-07-30
AU2013359238B2 true AU2013359238B2 (en) 2016-07-14

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AU2013359238A Active AU2013359238B2 (en) 2012-12-12 2013-12-12 CRISPR-Cas systems and methods for altering expression of gene products
AU2016244244A Active AU2016244244B2 (en) 2012-12-12 2016-10-12 CRISPR-Cas systems and methods for altering expression of gene products
AU2019201608A Active AU2019201608B2 (en) 2012-12-12 2019-03-08 CRISPR-Cas systems and methods for altering expression of gene products
AU2022201052A Active AU2022201052B2 (en) 2012-12-12 2022-02-17 CRISPR-Cas systems and methods for altering expression of gene products
AU2025202729A Pending AU2025202729A1 (en) 2012-12-12 2025-04-17 CRISPR-Cas systems and methods for altering expression of gene products

Family Applications After (4)

Application Number Title Priority Date Filing Date
AU2016244244A Active AU2016244244B2 (en) 2012-12-12 2016-10-12 CRISPR-Cas systems and methods for altering expression of gene products
AU2019201608A Active AU2019201608B2 (en) 2012-12-12 2019-03-08 CRISPR-Cas systems and methods for altering expression of gene products
AU2022201052A Active AU2022201052B2 (en) 2012-12-12 2022-02-17 CRISPR-Cas systems and methods for altering expression of gene products
AU2025202729A Pending AU2025202729A1 (en) 2012-12-12 2025-04-17 CRISPR-Cas systems and methods for altering expression of gene products

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Country Link
US (8) US8697359B1 (enExample)
EP (2) EP2998400A1 (enExample)
JP (6) JP6545621B2 (enExample)
KR (1) KR20150107739A (enExample)
CN (4) CN111187772B (enExample)
AU (5) AU2013359238B2 (enExample)
BR (1) BR112015013785A2 (enExample)
CA (1) CA2894688A1 (enExample)
DK (1) DK2764103T3 (enExample)
ES (1) ES2552535T3 (enExample)
HK (1) HK1216259A1 (enExample)
PL (1) PL2764103T3 (enExample)
PT (1) PT2764103E (enExample)
RU (1) RU2687451C1 (enExample)
WO (1) WO2014093661A2 (enExample)

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JP2013528062A (ja) 2010-06-11 2013-07-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｘｙｅｓ細胞からの繁殖可能なｘｙ雌動物の生成
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CA2853829C (en) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
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