ATE346858T1 - Antikörperreinigung durch hydrophobe wechselwirkungchromatografie bei niedrigem ph - Google Patents

Antikörperreinigung durch hydrophobe wechselwirkungchromatografie bei niedrigem ph

Info

Publication number
ATE346858T1
ATE346858T1 AT96912575T AT96912575T ATE346858T1 AT E346858 T1 ATE346858 T1 AT E346858T1 AT 96912575 T AT96912575 T AT 96912575T AT 96912575 T AT96912575 T AT 96912575T AT E346858 T1 ATE346858 T1 AT E346858T1
Authority
AT
Austria
Prior art keywords
antibodies
cleaning
low
hydrophobic interaction
interaction chromatography
Prior art date
Application number
AT96912575T
Other languages
English (en)
Inventor
Ernst H Rinderknecht
Gerardo A Zapata
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE346858T1 publication Critical patent/ATE346858T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/803—Physical recovery methods, e.g. chromatography, grinding
AT96912575T 1995-04-20 1996-04-05 Antikörperreinigung durch hydrophobe wechselwirkungchromatografie bei niedrigem ph ATE346858T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/425,763 US5641870A (en) 1995-04-20 1995-04-20 Low pH hydrophobic interaction chromatography for antibody purification

Publications (1)

Publication Number Publication Date
ATE346858T1 true ATE346858T1 (de) 2006-12-15

Family

ID=23687930

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96912575T ATE346858T1 (de) 1995-04-20 1996-04-05 Antikörperreinigung durch hydrophobe wechselwirkungchromatografie bei niedrigem ph
AT06022818T ATE510854T1 (de) 1995-04-20 1996-04-05 Lineares, schweres antikörperkettenfragment vh- ch1-vh-ch1

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT06022818T ATE510854T1 (de) 1995-04-20 1996-04-05 Lineares, schweres antikörperkettenfragment vh- ch1-vh-ch1

Country Status (16)

Country Link
US (5) US5641870A (de)
EP (2) EP0821695B1 (de)
JP (3) JP4042868B2 (de)
AT (2) ATE346858T1 (de)
AU (1) AU721736B2 (de)
CA (1) CA2214633C (de)
DE (1) DE69636733T2 (de)
DK (2) DK0821695T3 (de)
ES (2) ES2277344T3 (de)
HK (1) HK1099310A1 (de)
IL (1) IL117942A (de)
MX (1) MX9707909A (de)
NZ (2) NZ306718A (de)
PT (1) PT821695E (de)
WO (1) WO1996033208A1 (de)
ZA (1) ZA962885B (de)

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JP4042868B2 (ja) 2008-02-06
WO1996033208A1 (en) 1996-10-24
AU5534996A (en) 1996-11-07
ATE510854T1 (de) 2011-06-15
US20050271654A1 (en) 2005-12-08
EP0821695A1 (de) 1998-02-04
US7038017B2 (en) 2006-05-02
EP1752465B1 (de) 2011-05-25
IL117942A (en) 2000-06-01
ES2277344T3 (es) 2007-07-01
JPH11504007A (ja) 1999-04-06
NZ306718A (en) 1999-04-29
DE69636733D1 (de) 2007-01-11
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JP4091087B2 (ja) 2008-05-28
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DK0821695T3 (da) 2007-03-26
AU721736B2 (en) 2000-07-13
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IL117942A0 (en) 1996-08-04
EP1752465A2 (de) 2007-02-14
PT821695E (pt) 2007-03-30
ZA962885B (en) 1997-10-13
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US5641870A (en) 1997-06-24
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