MX2020003472A - Variante e isoforma de anticuerpos con actividad biologica reducida. - Google Patents
Variante e isoforma de anticuerpos con actividad biologica reducida.Info
- Publication number
- MX2020003472A MX2020003472A MX2020003472A MX2020003472A MX2020003472A MX 2020003472 A MX2020003472 A MX 2020003472A MX 2020003472 A MX2020003472 A MX 2020003472A MX 2020003472 A MX2020003472 A MX 2020003472A MX 2020003472 A MX2020003472 A MX 2020003472A
- Authority
- MX
- Mexico
- Prior art keywords
- isoforms
- isoform
- biological activity
- antibody
- antibody variant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a Variantes e isoformas de anticuerpos que tienen una actividad mimética de FVIII reducida en comparación con el Emicizumab, en donde las variantes de los anticuerpos tienen algunos residuos de aminoácido específicos en la región variable escindidos y faltantes (Variantes con corte de Q-CDR), y las isoformas de anticuerpo tienen uniones de disulfuro entre las cadenas pesadas que son menos susceptibles a la reducción bajo condiciones reductoras suaves (Isoformas de Disulfuros Protegidos).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017212179 | 2017-11-01 | ||
PCT/JP2018/040436 WO2019088143A1 (ja) | 2017-11-01 | 2018-10-31 | 生物活性が低下した抗体バリアントおよびアイソフォーム |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020003472A true MX2020003472A (es) | 2020-08-03 |
Family
ID=66331990
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020003472A MX2020003472A (es) | 2017-11-01 | 2018-10-31 | Variante e isoforma de anticuerpos con actividad biologica reducida. |
Country Status (19)
Country | Link |
---|---|
US (1) | US20200283544A1 (es) |
EP (1) | EP3705496A4 (es) |
JP (2) | JPWO2019088143A1 (es) |
KR (1) | KR20200074209A (es) |
CN (1) | CN111479829A (es) |
AR (1) | AR113816A1 (es) |
AU (1) | AU2018361430A1 (es) |
BR (1) | BR112020008393A2 (es) |
CA (1) | CA3079053A1 (es) |
CL (1) | CL2020001113A1 (es) |
CR (1) | CR20200229A (es) |
IL (1) | IL274265A (es) |
MA (1) | MA50534A (es) |
MX (1) | MX2020003472A (es) |
PE (1) | PE20210553A1 (es) |
SA (1) | SA520411871B1 (es) |
SG (1) | SG11202003833TA (es) |
TW (1) | TW201930352A (es) |
WO (1) | WO2019088143A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3689912A1 (en) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
TWI609698B (zh) | 2010-01-20 | 2018-01-01 | Chugai Pharmaceutical Co Ltd | 穩定化的含抗體溶液製劑 |
TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
JP7219005B2 (ja) | 2015-12-28 | 2023-02-07 | 中外製薬株式会社 | Fc領域含有ポリペプチドの精製を効率化するための方法 |
CN109661241A (zh) | 2016-09-06 | 2019-04-19 | 中外制药株式会社 | 使用识别凝血因子ix和/或活化凝血因子ix以及凝血因子x和/或活化凝血因子x的双特异性抗体的方法 |
SG11202003833TA (en) | 2017-11-01 | 2020-05-28 | Chugai Pharmaceutical Co Ltd | Antibody variant and isoform with lowered biological activity |
TW202340249A (zh) * | 2021-12-22 | 2023-10-16 | 日商中外製藥股份有限公司 | 生物活性降低之抗體變體 |
CN114544839A (zh) * | 2022-01-20 | 2022-05-27 | 未名生物医药有限公司 | 一种抗人神经生长因子抗体的电荷变异体检测方法 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
AU2003271174A1 (en) | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
AU2003271186A1 (en) | 2003-10-14 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
WO2006109592A1 (ja) | 2005-04-08 | 2006-10-19 | Chugai Seiyaku Kabushiki Kaisha | 血液凝固第viii因子の機能代替抗体 |
CN101460622A (zh) * | 2006-03-31 | 2009-06-17 | 中外制药株式会社 | 用于纯化双特异性抗体的抗体修饰方法 |
US9670269B2 (en) * | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
BRPI0716762A2 (pt) * | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
EP3689912A1 (en) * | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
MX355060B (es) * | 2010-11-17 | 2018-04-03 | Chugai Pharmaceutical Co Ltd | Molecula multiespecifica de union a antigeno que tiene funcion alternativa a la funcion del factor viii de coagulacion sanguinea. |
WO2012091023A1 (ja) * | 2010-12-27 | 2012-07-05 | 協和発酵キリン株式会社 | 培地およびキレート剤を含む水溶液の調製方法 |
EP2788097A4 (en) | 2011-12-07 | 2015-09-09 | Amgen Inc | IGG2 DISULFIDE ISOFORMATION SEPARATION |
GB201203051D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
WO2016164708A1 (en) * | 2015-04-10 | 2016-10-13 | Adimab, Llc | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
US20200270363A1 (en) * | 2015-12-25 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
SG11202003833TA (en) | 2017-11-01 | 2020-05-28 | Chugai Pharmaceutical Co Ltd | Antibody variant and isoform with lowered biological activity |
-
2018
- 2018-10-31 SG SG11202003833TA patent/SG11202003833TA/en unknown
- 2018-10-31 WO PCT/JP2018/040436 patent/WO2019088143A1/ja unknown
- 2018-10-31 JP JP2019550437A patent/JPWO2019088143A1/ja not_active Withdrawn
- 2018-10-31 PE PE2020000451A patent/PE20210553A1/es unknown
- 2018-10-31 KR KR1020207015464A patent/KR20200074209A/ko not_active Application Discontinuation
- 2018-10-31 BR BR112020008393-3A patent/BR112020008393A2/pt unknown
- 2018-10-31 US US16/758,128 patent/US20200283544A1/en active Pending
- 2018-10-31 EP EP18873627.6A patent/EP3705496A4/en active Pending
- 2018-10-31 AR ARP180103169A patent/AR113816A1/es unknown
- 2018-10-31 AU AU2018361430A patent/AU2018361430A1/en active Pending
- 2018-10-31 CA CA3079053A patent/CA3079053A1/en active Pending
- 2018-10-31 MX MX2020003472A patent/MX2020003472A/es unknown
- 2018-10-31 MA MA050534A patent/MA50534A/fr unknown
- 2018-10-31 CR CR20200229A patent/CR20200229A/es unknown
- 2018-10-31 TW TW107138518A patent/TW201930352A/zh unknown
- 2018-10-31 CN CN201880080142.XA patent/CN111479829A/zh active Pending
-
2020
- 2020-04-27 CL CL2020001113A patent/CL2020001113A1/es unknown
- 2020-04-27 IL IL274265A patent/IL274265A/en unknown
- 2020-04-29 SA SA520411871A patent/SA520411871B1/ar unknown
-
2023
- 2023-11-29 JP JP2023202127A patent/JP2024037761A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2018361430A1 (en) | 2020-06-11 |
TW201930352A (zh) | 2019-08-01 |
WO2019088143A1 (ja) | 2019-05-09 |
BR112020008393A2 (pt) | 2020-11-03 |
RU2020117440A3 (es) | 2022-04-01 |
CA3079053A1 (en) | 2019-05-09 |
KR20200074209A (ko) | 2020-06-24 |
EP3705496A1 (en) | 2020-09-09 |
MA50534A (fr) | 2020-09-09 |
SA520411871B1 (ar) | 2023-12-19 |
AR113816A1 (es) | 2020-06-17 |
CL2020001113A1 (es) | 2020-11-20 |
SG11202003833TA (en) | 2020-05-28 |
CR20200229A (es) | 2020-07-12 |
EP3705496A4 (en) | 2021-12-08 |
CN111479829A (zh) | 2020-07-31 |
PE20210553A1 (es) | 2021-03-17 |
JPWO2019088143A1 (ja) | 2020-11-12 |
IL274265A (en) | 2020-06-30 |
RU2020117440A (ru) | 2021-12-01 |
JP2024037761A (ja) | 2024-03-19 |
US20200283544A1 (en) | 2020-09-10 |
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