AR092691A1 - Composicion farmaceutica que comprende rebamipida - Google Patents
Composicion farmaceutica que comprende rebamipidaInfo
- Publication number
- AR092691A1 AR092691A1 ARP130103458A ARP130103458A AR092691A1 AR 092691 A1 AR092691 A1 AR 092691A1 AR P130103458 A ARP130103458 A AR P130103458A AR P130103458 A ARP130103458 A AR P130103458A AR 092691 A1 AR092691 A1 AR 092691A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- rebamipida
- composition according
- rebamipide
- zinc
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una composición oftálmica que contiene rebamipida que logra una superior redispersabilidad y transparencia porque comprende diversos aditivos, así como un compuesto de zinc como un conservante (que suplementa el efecto antiséptico) en la cantidad que no produce un efecto adverso. Reivindicación 3: La composición farmacéutica de acuerdo con la reivindicación 1 ó 2, caracterizada porque la concentración de zinc en el compuesto de zinc es del 0,000001 al 0,00005% (p/v). Reivindicación 5: La composición farmacéutica de acuerdo con cualquiera de las reivindicaciones 1 a 4 caracterizada porque las concentraciones de rebamipida, el agente solubilizante, el aminoazúcar y el tampón son del 1 al 3% (p/v), del 2 al 4% (p/v), del 1 al 6% (p/v) y del 0,05 al 2% (p/v), respectivamente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261707386P | 2012-09-28 | 2012-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR092691A1 true AR092691A1 (es) | 2015-04-29 |
Family
ID=49448234
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130103458A AR092691A1 (es) | 2012-09-28 | 2013-09-26 | Composicion farmaceutica que comprende rebamipida |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20150246032A1 (es) |
| EP (1) | EP2900214A1 (es) |
| JP (1) | JP2015531338A (es) |
| KR (1) | KR20150063084A (es) |
| CN (1) | CN104661650A (es) |
| AR (1) | AR092691A1 (es) |
| AU (1) | AU2013320866A1 (es) |
| BR (1) | BR112015006464A2 (es) |
| CA (1) | CA2881374A1 (es) |
| EA (1) | EA201590651A1 (es) |
| HK (2) | HK1210711A1 (es) |
| IL (1) | IL237146A0 (es) |
| MX (1) | MX2015004028A (es) |
| PH (1) | PH12015500704A1 (es) |
| SG (1) | SG11201502033YA (es) |
| TW (1) | TW201417814A (es) |
| WO (1) | WO2014051163A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170039347A (ko) | 2015-10-01 | 2017-04-11 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| KR102307958B1 (ko) | 2015-10-01 | 2021-10-05 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| US11324829B2 (en) | 2016-03-14 | 2022-05-10 | Santen Pharmaceutical Co., Ltd. | Antiseptic agent comprising meglumine or salt thereof |
| KR101840256B1 (ko) * | 2017-09-21 | 2018-03-21 | 대우제약 주식회사 | 레바미피드를 함유하는 새로운 안구건조증 치료용 점안 조성물 및 이의 가용화 및 안정화 방법 |
| KR101923519B1 (ko) * | 2018-06-26 | 2019-02-27 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
| TW202320815A (zh) * | 2021-09-30 | 2023-06-01 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI394564B (zh) * | 2006-09-21 | 2013-05-01 | Alcon Res Ltd | 自行保存型水性藥學組成物 |
| CN101516332B (zh) * | 2006-09-21 | 2012-12-19 | 爱尔康研究有限公司 | 自身防腐的水性药物组合物 |
| WO2008074853A1 (en) * | 2006-12-21 | 2008-06-26 | Novartis Ag | Ophthalmic rebamipide solution |
| DK2285413T3 (da) * | 2008-06-19 | 2012-08-27 | Otsuka Pharma Co Ltd | Farmaceutisk sammensætning |
| US20110052678A1 (en) * | 2010-11-05 | 2011-03-03 | Shantha Totada R | Method for treating age related macular degeneration |
| TW201322982A (zh) * | 2011-11-01 | 2013-06-16 | Otsuka Pharma Co Ltd | 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑 |
| CN102512420A (zh) * | 2011-11-29 | 2012-06-27 | 北京阜康仁生物制药科技有限公司 | 一种以瑞巴派特的药用盐为活性成分的药用组合物 |
-
2013
- 2013-09-25 TW TW102134472A patent/TW201417814A/zh unknown
- 2013-09-26 AR ARP130103458A patent/AR092691A1/es unknown
- 2013-09-27 JP JP2015515329A patent/JP2015531338A/ja active Pending
- 2013-09-27 KR KR1020157010337A patent/KR20150063084A/ko not_active Application Discontinuation
- 2013-09-27 WO PCT/JP2013/077011 patent/WO2014051163A1/en active Application Filing
- 2013-09-27 MX MX2015004028A patent/MX2015004028A/es unknown
- 2013-09-27 EA EA201590651A patent/EA201590651A1/ru unknown
- 2013-09-27 CN CN201380050716.6A patent/CN104661650A/zh active Pending
- 2013-09-27 AU AU2013320866A patent/AU2013320866A1/en not_active Abandoned
- 2013-09-27 US US14/431,542 patent/US20150246032A1/en not_active Abandoned
- 2013-09-27 CA CA2881374A patent/CA2881374A1/en not_active Abandoned
- 2013-09-27 EP EP13779937.5A patent/EP2900214A1/en not_active Withdrawn
- 2013-09-27 BR BR112015006464A patent/BR112015006464A2/pt not_active IP Right Cessation
- 2013-09-27 SG SG11201502033YA patent/SG11201502033YA/en unknown
-
2015
- 2015-02-08 IL IL237146A patent/IL237146A0/en unknown
- 2015-03-27 PH PH12015500704A patent/PH12015500704A1/en unknown
- 2015-11-25 HK HK15111583.3A patent/HK1210711A1/xx unknown
- 2015-11-25 HK HK15111582.4A patent/HK1210710A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112015006464A2 (pt) | 2017-07-04 |
| IL237146A0 (en) | 2015-04-30 |
| PH12015500704A1 (en) | 2015-05-25 |
| EP2900214A1 (en) | 2015-08-05 |
| TW201417814A (zh) | 2014-05-16 |
| SG11201502033YA (en) | 2015-04-29 |
| CN104661650A (zh) | 2015-05-27 |
| JP2015531338A (ja) | 2015-11-02 |
| HK1210711A1 (en) | 2016-05-06 |
| CA2881374A1 (en) | 2014-04-03 |
| WO2014051163A1 (en) | 2014-04-03 |
| AU2013320866A1 (en) | 2015-02-26 |
| HK1210710A1 (en) | 2016-05-06 |
| EA201590651A1 (ru) | 2015-07-30 |
| MX2015004028A (es) | 2015-07-06 |
| KR20150063084A (ko) | 2015-06-08 |
| US20150246032A1 (en) | 2015-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |