BR112015006464A2 - composição farmacêutica compreendendo rebamipida - Google Patents

composição farmacêutica compreendendo rebamipida

Info

Publication number
BR112015006464A2
BR112015006464A2 BR112015006464A BR112015006464A BR112015006464A2 BR 112015006464 A2 BR112015006464 A2 BR 112015006464A2 BR 112015006464 A BR112015006464 A BR 112015006464A BR 112015006464 A BR112015006464 A BR 112015006464A BR 112015006464 A2 BR112015006464 A2 BR 112015006464A2
Authority
BR
Brazil
Prior art keywords
rebamipide
pharmaceutical composition
redispersion
supplements
preservative
Prior art date
Application number
BR112015006464A
Other languages
English (en)
Inventor
Kaiden Tomohiro
Sugahara Yuji
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of BR112015006464A2 publication Critical patent/BR112015006464A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Abstract

resumo patente de invenção: "composição farmacêutica compreendendo rebamipida". a presente invenção refere-se a uma composição oftálmica contendo rebamipida que alcança capacidade de redispersão e transparência superiores ao compreender vários aditivos bem como um composto de zinco como um conservante (que suplementa o efeito antisséptico) na quantidade que não produz um efeito adverso.
BR112015006464A 2012-09-28 2013-09-27 composição farmacêutica compreendendo rebamipida BR112015006464A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261707386P 2012-09-28 2012-09-28
PCT/JP2013/077011 WO2014051163A1 (en) 2012-09-28 2013-09-27 Pharmaceutical composition comprising rebamipide

Publications (1)

Publication Number Publication Date
BR112015006464A2 true BR112015006464A2 (pt) 2017-07-04

Family

ID=49448234

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015006464A BR112015006464A2 (pt) 2012-09-28 2013-09-27 composição farmacêutica compreendendo rebamipida

Country Status (17)

Country Link
US (1) US20150246032A1 (pt)
EP (1) EP2900214A1 (pt)
JP (1) JP2015531338A (pt)
KR (1) KR20150063084A (pt)
CN (1) CN104661650A (pt)
AR (1) AR092691A1 (pt)
AU (1) AU2013320866A1 (pt)
BR (1) BR112015006464A2 (pt)
CA (1) CA2881374A1 (pt)
EA (1) EA201590651A1 (pt)
HK (2) HK1210710A1 (pt)
IL (1) IL237146A0 (pt)
MX (1) MX2015004028A (pt)
PH (1) PH12015500704A1 (pt)
SG (1) SG11201502033YA (pt)
TW (1) TW201417814A (pt)
WO (1) WO2014051163A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170039347A (ko) 2015-10-01 2017-04-11 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
KR102307958B1 (ko) * 2015-10-01 2021-10-05 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
KR102429646B1 (ko) 2016-03-14 2022-08-04 산텐 세이야꾸 가부시키가이샤 메글루민 또는 그의 염을 포함하는 방부제
KR101840256B1 (ko) * 2017-09-21 2018-03-21 대우제약 주식회사 레바미피드를 함유하는 새로운 안구건조증 치료용 점안 조성물 및 이의 가용화 및 안정화 방법
KR101923519B1 (ko) * 2018-06-26 2019-02-27 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
TW202320815A (zh) * 2021-09-30 2023-06-01 日商樂敦製藥股份有限公司 眼科組成物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200901164B (en) * 2006-09-21 2010-06-30 Alcon Res Ltd Self preserved aqueous pharmaceutical compositions
TWI394564B (zh) * 2006-09-21 2013-05-01 Alcon Res Ltd 自行保存型水性藥學組成物
WO2008074853A1 (en) * 2006-12-21 2008-06-26 Novartis Ag Ophthalmic rebamipide solution
DK2285413T3 (da) * 2008-06-19 2012-08-27 Otsuka Pharma Co Ltd Farmaceutisk sammensætning
US20110052678A1 (en) * 2010-11-05 2011-03-03 Shantha Totada R Method for treating age related macular degeneration
TW201322982A (zh) * 2011-11-01 2013-06-16 Otsuka Pharma Co Ltd 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑
CN102512420A (zh) * 2011-11-29 2012-06-27 北京阜康仁生物制药科技有限公司 一种以瑞巴派特的药用盐为活性成分的药用组合物

Also Published As

Publication number Publication date
HK1210711A1 (en) 2016-05-06
JP2015531338A (ja) 2015-11-02
EP2900214A1 (en) 2015-08-05
TW201417814A (zh) 2014-05-16
CA2881374A1 (en) 2014-04-03
PH12015500704A1 (en) 2015-05-25
SG11201502033YA (en) 2015-04-29
EA201590651A1 (ru) 2015-07-30
MX2015004028A (es) 2015-07-06
KR20150063084A (ko) 2015-06-08
AR092691A1 (es) 2015-04-29
IL237146A0 (en) 2015-04-30
CN104661650A (zh) 2015-05-27
US20150246032A1 (en) 2015-09-03
HK1210710A1 (en) 2016-05-06
WO2014051163A1 (en) 2014-04-03
AU2013320866A1 (en) 2015-02-26

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]