BR112013033060A2 - solução oftálmica contendo ácido hialurônico ou sal deste e propileno glicol - Google Patents

solução oftálmica contendo ácido hialurônico ou sal deste e propileno glicol

Info

Publication number
BR112013033060A2
BR112013033060A2 BR112013033060A BR112013033060A BR112013033060A2 BR 112013033060 A2 BR112013033060 A2 BR 112013033060A2 BR 112013033060 A BR112013033060 A BR 112013033060A BR 112013033060 A BR112013033060 A BR 112013033060A BR 112013033060 A2 BR112013033060 A2 BR 112013033060A2
Authority
BR
Brazil
Prior art keywords
ophthalmic solution
salt
propylene glycol
hyaluronic acid
solution containing
Prior art date
Application number
BR112013033060A
Other languages
English (en)
Inventor
Atsuyoshi Dota
Koji Inagaki
Masatsugu Nakamura
Takashi Nagano
Toshihiro Ogawa
Yoshihide Horibe
Yuichiro Nakada
Original Assignee
Santen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co Ltd filed Critical Santen Pharmaceutical Co Ltd
Publication of BR112013033060A2 publication Critical patent/BR112013033060A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo patente de invenção: "solução oftálmica contendo ácido hialurônico ou sal deste e propileno glicol". a presente invenção refere-se a uma solução oftálmica aquosa que contém ácido hialurônico ou um sal deste em uma concentração de 0,03 a 0,5% (p/v) e propileno glicol em uma concentração de 0,1 a 1,0% (p/v), compreendendo como único conservante cloreto de benzalcônio em uma concentração de 0,001 a 0,002% (p/v) e um agente de tonicidade iônico em uma concentração tal que a taxa de pressão osmótica da solução oftálmica torne-se de 0,9 a 1,1. 20088848v1
BR112013033060A 2011-06-23 2012-06-22 solução oftálmica contendo ácido hialurônico ou sal deste e propileno glicol BR112013033060A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011139566 2011-06-23
PCT/JP2012/065957 WO2012176865A1 (ja) 2011-06-23 2012-06-22 ヒアルロン酸またはその塩およびプロピレングリコールを含有する点眼液

Publications (1)

Publication Number Publication Date
BR112013033060A2 true BR112013033060A2 (pt) 2017-01-24

Family

ID=47422693

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013033060A BR112013033060A2 (pt) 2011-06-23 2012-06-22 solução oftálmica contendo ácido hialurônico ou sal deste e propileno glicol

Country Status (16)

Country Link
US (1) US20140088039A1 (pt)
EP (1) EP2684560A4 (pt)
JP (1) JP5981783B2 (pt)
KR (1) KR101906631B1 (pt)
CN (1) CN103608000B (pt)
AU (2) AU2012274367A1 (pt)
BR (1) BR112013033060A2 (pt)
CA (1) CA2839822A1 (pt)
EA (1) EA025078B1 (pt)
GE (1) GEP20166459B (pt)
HK (1) HK1190089A1 (pt)
MX (1) MX345216B (pt)
MY (1) MY176112A (pt)
SG (1) SG10201605080VA (pt)
TW (2) TW201309306A (pt)
WO (1) WO2012176865A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY190393A (en) * 2015-03-06 2022-04-20 Santen Pharmaceutical Co Ltd Ophthalmic composition
US10391119B2 (en) * 2015-12-22 2019-08-27 Nof Corporation Lacrimal oily layer stabilizer and eye drops comprising same
FR3063649B1 (fr) * 2017-03-07 2021-05-21 Laboratoire De Rhumatologie Appliquee Nouvelle solution visco-elastique et son utilisation en rhumatologie
KR102268002B1 (ko) 2018-12-26 2021-06-23 (주)휴온스 효과 지속성 점안제 조성물
KR20230126522A (ko) * 2022-02-23 2023-08-30 주식회사 스카이테라퓨틱스 고분자 히알루론산의 구조체, 이의 제조방법 및 이를 포함하는 점안 조성물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322667A (en) * 1987-03-31 1994-06-21 Sherman Pharmaceuticals, Inc. Preservative system for ophthalmic and contact lens solutions and method for cleaning disinfecting and storing contact lenses
JPH01115902A (ja) 1987-10-30 1989-05-09 Showa Sangyo Co Ltd ヒアルロン酸の製造法
JP2530491B2 (ja) * 1988-12-20 1996-09-04 参天製薬株式会社 ヒアルロン酸点眼液
JPH1072376A (ja) * 1996-09-02 1998-03-17 Ofutekusu:Kk ヒアルロン酸含有点眼水溶液
EP1245233A4 (en) * 1999-12-27 2006-03-15 Santen Pharmaceutical Co Ltd SYSTEM FOR STABILIZING THE LACRYMAL FLUID LAYER
CA2428985C (en) * 2000-11-08 2011-05-24 Bio-Concept Laboratories Improved ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers
JP2002193815A (ja) * 2000-12-25 2002-07-10 Ophtecs Corp 眼手術用角膜乾燥防止点眼剤
JP2003002837A (ja) * 2001-06-21 2003-01-08 Lion Corp 水性外用剤組成物及び液体組成物の白濁防止方法
JP4694773B2 (ja) * 2003-06-06 2011-06-08 ロート製薬株式会社 粘膜適用液状組成物
NZ555501A (en) * 2004-11-24 2010-01-29 Medpointe Healthcare Inc Compositions comprising azelastine and methods of use thereof
CN1939534B (zh) * 2005-09-27 2010-12-01 长春金赛药业股份有限公司 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂
JPWO2007074904A1 (ja) * 2005-12-28 2009-06-04 わかもと製薬株式会社 水性医薬組成物
US20080050335A1 (en) * 2006-07-25 2008-02-28 Osmotica Corp. Ophthalmic Solutions
JPWO2008044734A1 (ja) * 2006-10-12 2010-02-18 杏林製薬株式会社 ガチフロキサシン含有水性液剤
JP2009161454A (ja) 2007-12-28 2009-07-23 Lion Corp 眼科用組成物
JP2009196903A (ja) 2008-02-19 2009-09-03 Lion Corp 眼科用組成物
EP2308468A1 (en) * 2009-10-08 2011-04-13 Novaliq GmbH Novel pharmaceutical composition comprising a macrolide immunosuppressant drug
JP5518608B2 (ja) * 2010-07-09 2014-06-11 ロート製薬株式会社 粘膜適用液状組成物

Also Published As

Publication number Publication date
JP5981783B2 (ja) 2016-08-31
CN103608000B (zh) 2016-05-11
GEP20166459B (en) 2016-04-11
CN103608000A (zh) 2014-02-26
JP2013028599A (ja) 2013-02-07
TWI704931B (zh) 2020-09-21
MX2013015273A (es) 2014-04-14
HK1190089A1 (zh) 2014-06-27
MX345216B (es) 2017-01-18
CA2839822A1 (en) 2012-12-27
NZ618822A (en) 2015-07-31
EP2684560A4 (en) 2014-08-06
SG10201605080VA (en) 2016-08-30
KR101906631B1 (ko) 2018-10-10
TW201309306A (zh) 2013-03-01
AU2012274367A1 (en) 2014-01-23
US20140088039A1 (en) 2014-03-27
KR20140041586A (ko) 2014-04-04
AU2017203905A1 (en) 2017-06-29
EA025078B1 (ru) 2016-11-30
AU2017203905B2 (en) 2019-07-11
TW201742620A (zh) 2017-12-16
EA201490127A1 (ru) 2014-04-30
MY176112A (en) 2020-07-24
EP2684560A1 (en) 2014-01-15
WO2012176865A1 (ja) 2012-12-27

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]