MX345216B - Solucion oftalmica que contiene acido hialuronico o sal del mismo y propilenglicol. - Google Patents
Solucion oftalmica que contiene acido hialuronico o sal del mismo y propilenglicol.Info
- Publication number
- MX345216B MX345216B MX2013015273A MX2013015273A MX345216B MX 345216 B MX345216 B MX 345216B MX 2013015273 A MX2013015273 A MX 2013015273A MX 2013015273 A MX2013015273 A MX 2013015273A MX 345216 B MX345216 B MX 345216B
- Authority
- MX
- Mexico
- Prior art keywords
- ophthalmic solution
- salt
- propylene glycol
- hyaluronic acid
- solution containing
- Prior art date
Links
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 title abstract 6
- 229940054534 ophthalmic solution Drugs 0.000 title abstract 3
- 239000002997 ophthalmic solution Substances 0.000 title abstract 3
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229960000686 benzalkonium chloride Drugs 0.000 abstract 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 239000012929 tonicity agent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una solución oftálmica basada en agua que comprende ácido hialurónico o una sal del mismo en una concentración desde 0.03 a 0.5% (p/v) y propilenglicol en una concentración desde 0.1 a 1.0% (p/v), en donde el cloruro de benzalconio está contenido en una concentración desde 0.001 a 0.002% (p/v) como único agente conservador y un agente de tonicidad iónico contenido en tal concentración que una relación de presión osmótica de la solución oftálmica se convierte de 0.9 a 1.1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011139566 | 2011-06-23 | ||
| PCT/JP2012/065957 WO2012176865A1 (ja) | 2011-06-23 | 2012-06-22 | ヒアルロン酸またはその塩およびプロピレングリコールを含有する点眼液 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013015273A MX2013015273A (es) | 2014-04-14 |
| MX345216B true MX345216B (es) | 2017-01-18 |
Family
ID=47422693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013015273A MX345216B (es) | 2011-06-23 | 2012-06-22 | Solucion oftalmica que contiene acido hialuronico o sal del mismo y propilenglicol. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20140088039A1 (es) |
| EP (1) | EP2684560A4 (es) |
| JP (1) | JP5981783B2 (es) |
| KR (1) | KR101906631B1 (es) |
| CN (1) | CN103608000B (es) |
| AU (2) | AU2012274367A1 (es) |
| BR (1) | BR112013033060A2 (es) |
| CA (1) | CA2839822A1 (es) |
| EA (1) | EA025078B1 (es) |
| GE (1) | GEP20166459B (es) |
| MX (1) | MX345216B (es) |
| MY (1) | MY176112A (es) |
| PH (1) | PH12013502476B1 (es) |
| SG (1) | SG10201605080VA (es) |
| TW (2) | TW201309306A (es) |
| WO (1) | WO2012176865A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201901426WA (en) * | 2015-03-06 | 2019-03-28 | Santen Pharmaceutical Co Ltd | Ophthalmic composition |
| KR20180081597A (ko) * | 2015-12-22 | 2018-07-16 | 니치유 가부시키가이샤 | 누액 유층 안정화제 및 이것을 함유하는 점안제 |
| FR3063649B1 (fr) * | 2017-03-07 | 2021-05-21 | Laboratoire De Rhumatologie Appliquee | Nouvelle solution visco-elastique et son utilisation en rhumatologie |
| KR102268002B1 (ko) | 2018-12-26 | 2021-06-23 | (주)휴온스 | 효과 지속성 점안제 조성물 |
| KR102726207B1 (ko) * | 2022-02-23 | 2024-11-05 | 주식회사 스카이테라퓨틱스 | 고분자 히알루론산의 구조체, 이의 제조방법 및 이를 포함하는 점안 조성물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5322667A (en) * | 1987-03-31 | 1994-06-21 | Sherman Pharmaceuticals, Inc. | Preservative system for ophthalmic and contact lens solutions and method for cleaning disinfecting and storing contact lenses |
| JPH01115902A (ja) | 1987-10-30 | 1989-05-09 | Showa Sangyo Co Ltd | ヒアルロン酸の製造法 |
| JP2530491B2 (ja) * | 1988-12-20 | 1996-09-04 | 参天製薬株式会社 | ヒアルロン酸点眼液 |
| JPH1072376A (ja) * | 1996-09-02 | 1998-03-17 | Ofutekusu:Kk | ヒアルロン酸含有点眼水溶液 |
| US7147844B2 (en) * | 1999-12-27 | 2006-12-12 | Santen Pharmaceutical Co., Ltd. | System for stabilizing lacrimal fluid layer |
| US9492581B2 (en) * | 2000-11-08 | 2016-11-15 | Fxs Ventures, Llc | Ophthalmic and contact lens solutions containing simple saccharides as preservative enhancers |
| JP2002193815A (ja) * | 2000-12-25 | 2002-07-10 | Ophtecs Corp | 眼手術用角膜乾燥防止点眼剤 |
| JP2003002837A (ja) * | 2001-06-21 | 2003-01-08 | Lion Corp | 水性外用剤組成物及び液体組成物の白濁防止方法 |
| JP4694773B2 (ja) * | 2003-06-06 | 2011-06-08 | ロート製薬株式会社 | 粘膜適用液状組成物 |
| EP2522365B1 (en) * | 2004-11-24 | 2016-10-26 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| CN1939534B (zh) * | 2005-09-27 | 2010-12-01 | 长春金赛药业股份有限公司 | 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂 |
| JPWO2007074904A1 (ja) * | 2005-12-28 | 2009-06-04 | わかもと製薬株式会社 | 水性医薬組成物 |
| KR20090053892A (ko) * | 2006-07-25 | 2009-05-28 | 오스모티카 코프. | 점안액 |
| BRPI0719514A2 (pt) * | 2006-10-12 | 2014-10-07 | Kyorin Seiyaku Kk | Preparações líquidas aquosas compreendendo gatifloxacina |
| JP2009161454A (ja) | 2007-12-28 | 2009-07-23 | Lion Corp | 眼科用組成物 |
| JP2009196903A (ja) | 2008-02-19 | 2009-09-03 | Lion Corp | 眼科用組成物 |
| EP2308468A1 (en) * | 2009-10-08 | 2011-04-13 | Novaliq GmbH | Novel pharmaceutical composition comprising a macrolide immunosuppressant drug |
| JP5518608B2 (ja) * | 2010-07-09 | 2014-06-11 | ロート製薬株式会社 | 粘膜適用液状組成物 |
-
2012
- 2012-06-22 EA EA201490127A patent/EA025078B1/ru not_active IP Right Cessation
- 2012-06-22 KR KR1020137034299A patent/KR101906631B1/ko not_active Expired - Fee Related
- 2012-06-22 MY MYPI2013004514A patent/MY176112A/en unknown
- 2012-06-22 WO PCT/JP2012/065957 patent/WO2012176865A1/ja not_active Ceased
- 2012-06-22 US US14/116,459 patent/US20140088039A1/en not_active Abandoned
- 2012-06-22 TW TW101122328A patent/TW201309306A/zh unknown
- 2012-06-22 AU AU2012274367A patent/AU2012274367A1/en not_active Abandoned
- 2012-06-22 TW TW106116311A patent/TWI704931B/zh not_active IP Right Cessation
- 2012-06-22 BR BR112013033060A patent/BR112013033060A2/pt not_active IP Right Cessation
- 2012-06-22 GE GEAP201213357A patent/GEP20166459B/en unknown
- 2012-06-22 MX MX2013015273A patent/MX345216B/es active IP Right Grant
- 2012-06-22 PH PH1/2013/502476A patent/PH12013502476B1/en unknown
- 2012-06-22 CN CN201280029945.5A patent/CN103608000B/zh not_active Expired - Fee Related
- 2012-06-22 JP JP2012140951A patent/JP5981783B2/ja active Active
- 2012-06-22 SG SG10201605080VA patent/SG10201605080VA/en unknown
- 2012-06-22 EP EP12802671.3A patent/EP2684560A4/en not_active Withdrawn
- 2012-06-22 CA CA2839822A patent/CA2839822A1/en not_active Abandoned
-
2017
- 2017-06-09 AU AU2017203905A patent/AU2017203905B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| NZ618822A (en) | 2015-07-31 |
| CN103608000A (zh) | 2014-02-26 |
| PH12013502476B1 (en) | 2019-04-17 |
| EA201490127A1 (ru) | 2014-04-30 |
| EA025078B1 (ru) | 2016-11-30 |
| TW201742620A (zh) | 2017-12-16 |
| GEP20166459B (en) | 2016-04-11 |
| EP2684560A1 (en) | 2014-01-15 |
| TWI704931B (zh) | 2020-09-21 |
| KR101906631B1 (ko) | 2018-10-10 |
| SG10201605080VA (en) | 2016-08-30 |
| US20140088039A1 (en) | 2014-03-27 |
| TW201309306A (zh) | 2013-03-01 |
| WO2012176865A1 (ja) | 2012-12-27 |
| JP2013028599A (ja) | 2013-02-07 |
| CN103608000B (zh) | 2016-05-11 |
| CA2839822A1 (en) | 2012-12-27 |
| EP2684560A4 (en) | 2014-08-06 |
| HK1190089A1 (zh) | 2014-06-27 |
| KR20140041586A (ko) | 2014-04-04 |
| JP5981783B2 (ja) | 2016-08-31 |
| AU2017203905B2 (en) | 2019-07-11 |
| MX2013015273A (es) | 2014-04-14 |
| AU2017203905A1 (en) | 2017-06-29 |
| BR112013033060A2 (pt) | 2017-01-24 |
| PH12013502476A1 (en) | 2014-01-20 |
| MY176112A (en) | 2020-07-24 |
| AU2012274367A1 (en) | 2014-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |