MX341189B - Composicion liquida y acousa de bromfenaco, que tiene efectividad conservadora. - Google Patents

Composicion liquida y acousa de bromfenaco, que tiene efectividad conservadora.

Info

Publication number
MX341189B
MX341189B MX2013008277A MX2013008277A MX341189B MX 341189 B MX341189 B MX 341189B MX 2013008277 A MX2013008277 A MX 2013008277A MX 2013008277 A MX2013008277 A MX 2013008277A MX 341189 B MX341189 B MX 341189B
Authority
MX
Mexico
Prior art keywords
aqueous liquid
liquid composition
bromfenac
preservative efficiency
bromfenac aqueous
Prior art date
Application number
MX2013008277A
Other languages
English (en)
Other versions
MX2013008277A (es
Inventor
Nishihata Shuichi
Asayama Wakiko
Iemoto Suzuka
Original Assignee
Senju Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senju Pharma Co filed Critical Senju Pharma Co
Publication of MX2013008277A publication Critical patent/MX2013008277A/es
Publication of MX341189B publication Critical patent/MX341189B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una composición líquida y acuosa de bromfenaco que contiene (a) bromfenaco o una sal de éste y (b) cloruro de benzalconio, que se caracteriza porque la composición tiene eficacia conservadora, y en que la concentración de (b) cloruro de benzalconio es mayor a 0.0005% y menor a 0.005%.
MX2013008277A 2011-01-18 2012-01-18 Composicion liquida y acousa de bromfenaco, que tiene efectividad conservadora. MX341189B (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2011007898 2011-01-18
JP2011199480 2011-09-13
JP2011289640 2011-12-28
PCT/JP2012/050903 WO2012099142A1 (ja) 2011-01-18 2012-01-18 保存効力を有するブロムフェナク水性液剤組成物

Publications (2)

Publication Number Publication Date
MX2013008277A MX2013008277A (es) 2013-11-01
MX341189B true MX341189B (es) 2016-08-09

Family

ID=46515765

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013008277A MX341189B (es) 2011-01-18 2012-01-18 Composicion liquida y acousa de bromfenaco, que tiene efectividad conservadora.

Country Status (9)

Country Link
US (2) US9107888B2 (es)
JP (1) JPWO2012099142A1 (es)
KR (1) KR102075173B1 (es)
CN (1) CN103379904A (es)
BR (1) BR112013018025A2 (es)
CA (1) CA2824433C (es)
MX (1) MX341189B (es)
RU (1) RU2625755C2 (es)
WO (1) WO2012099142A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI604858B (zh) * 2012-03-28 2017-11-11 參天製藥股份有限公司 含有２－胺基－３－（４－溴苯甲醯基）苯基醋酸之水性組成物及其製造方法
CN105451731B (zh) * 2013-09-26 2019-01-18 参天制药株式会社 含有经稳定化的2－氨基－3－(4－溴苯甲酰基)苯乙酸的水性组合物
WO2016195072A1 (ja) * 2015-06-05 2016-12-08 参天製薬株式会社 ソフトコンタクトレンズが装用されたドライアイ患者の眼に点眼されるように用いられることを特徴とするドライアイ治療剤
CN111712238A (zh) 2017-12-14 2020-09-25 参天制药株式会社 含有2-氨基-3-（4-溴苯甲酰基）苯乙酸或其盐的滴眼剂
JP7172438B2 (ja) * 2018-10-24 2022-11-16 ライオン株式会社 水性眼科用組成物及び保存効力向上方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414011A (en) 1987-09-11 1995-05-09 Syntex (U.S.A.) Inc. Preservative system for ophthalmic formulations
CA1325382C (en) 1988-01-27 1993-12-21 Takahiro Ogawa Locally administrable therapeutic composition for inflammatory disease
US5603929A (en) 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
JPH10109930A (ja) * 1996-10-04 1998-04-28 Taisho Pharmaceut Co Ltd 点眼剤
JP4489851B2 (ja) 1997-02-04 2010-06-23 千寿製薬株式会社 アリールカルボン酸の安定化方法、その安定化剤および安定化されたアリールカルボン酸からなる水性液剤
US6274592B1 (en) 1997-02-04 2001-08-14 Senju Pharmaceutical Co., Ltd. Method for stabilizing arylcarboxylic acid, stabilizer thereof and aqueous solution containing stabilized arylcarboxylic acid
US5942508A (en) 1997-02-04 1999-08-24 Senju Pharmaceutical Co., Ltd. Method for solubilizing pyridonecarboxylic acid solubilizer thereof and aqueous solution containing solubilized pyridonecarboxylic acid
JP4707201B2 (ja) 1997-02-04 2011-06-22 千寿製薬株式会社 ピリドンカルボン酸の可溶化方法、その可溶化剤および可溶化されたピリドンカルボン酸からなる水性液剤
UA80682C2 (en) * 2001-08-06 2007-10-25 Pharmacia Corp Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition
JP3755493B2 (ja) 2002-07-25 2006-03-15 株式会社デンソー 回転電機のステータ
KR100452341B1 (ko) 2003-01-10 2004-10-15 김기정 고압방전등용 자기식 안정기의 단락 보호회로
EP1586316B1 (en) 2003-01-21 2008-04-30 Senju Pharmaceutical Co., Ltd. Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid
JP2005046700A (ja) 2003-07-31 2005-02-24 Nippon Shokubai Co Ltd 担持無機物の製造方法
JP4674162B2 (ja) 2003-11-14 2011-04-20 千寿製薬株式会社 アミノグリコシド系抗生物質およびブロムフェナクを含有する水溶液製剤
JP5110776B2 (ja) 2004-07-01 2012-12-26 セイコーインスツル株式会社 半導体装置の製造方法
JP2006049250A (ja) 2004-07-30 2006-02-16 Takayuki Shimamune 加熱装置
PL1808170T3 (pl) * 2004-11-05 2011-12-30 Senju Pharma Co Wodne krople do oczu z przyśpieszoną migracją wewnątrzgałkową
KR100679085B1 (ko) 2005-04-27 2007-02-05 황도연 카메라장치 및 그의 데이터처리방법
CN101313899B (zh) * 2007-06-01 2012-02-29 北京德众万全药物技术开发有限公司 一种含有溴芬酸钠的眼用药物组合物
JP2009161454A (ja) 2007-12-28 2009-07-23 Lion Corp 眼科用組成物
CA2937997A1 (en) * 2008-06-12 2009-12-17 Foresight Biotherapeutics, Inc. Povidone iodine, a novel alternative preservative for ophthalmic compositions
TWI489997B (zh) * 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物

Also Published As

Publication number Publication date
RU2013138459A (ru) 2015-02-27
CA2824433C (en) 2019-11-12
US20130281537A1 (en) 2013-10-24
RU2625755C2 (ru) 2017-07-18
CA2824433A1 (en) 2012-07-26
WO2012099142A1 (ja) 2012-07-26
MX2013008277A (es) 2013-11-01
US20150306222A1 (en) 2015-10-29
JPWO2012099142A1 (ja) 2014-06-30
RU2017123806A3 (es) 2020-12-24
BR112013018025A2 (pt) 2020-10-27
CN103379904A (zh) 2013-10-30
KR20140012061A (ko) 2014-01-29
US9561280B2 (en) 2017-02-07
US9107888B2 (en) 2015-08-18
KR102075173B1 (ko) 2020-02-07
RU2017123806A (ru) 2019-01-30

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