AR105199A1 - Soluciones oftálmicas acuosas - Google Patents
Soluciones oftálmicas acuosasInfo
- Publication number
- AR105199A1 AR105199A1 ARP160101981A ARP160101981A AR105199A1 AR 105199 A1 AR105199 A1 AR 105199A1 AR P160101981 A ARP160101981 A AR P160101981A AR P160101981 A ARP160101981 A AR P160101981A AR 105199 A1 AR105199 A1 AR 105199A1
- Authority
- AR
- Argentina
- Prior art keywords
- aqueous ophthalmic
- ophthalmic solution
- concentration
- chlorhexidine
- salt
- Prior art date
Links
- 239000002997 ophthalmic solution Substances 0.000 title abstract 11
- 229940054534 ophthalmic solution Drugs 0.000 abstract 10
- 229960003260 chlorhexidine Drugs 0.000 abstract 9
- -1 chlorhexidine compound Chemical class 0.000 abstract 8
- 150000003839 salts Chemical class 0.000 abstract 6
- 239000002738 chelating agent Substances 0.000 abstract 2
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 abstract 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C13/00—Assembling; Repairing; Cleaning
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Materials For Medical Uses (AREA)
Abstract
Una solución oftálmica acuosa que incluye dicuafosol o una sal del mismo en una concentración de entre 0,1 y 10% (p/v) y un compuesto de clorhexidina en una concentración de entre 0,0001 y 0,1% (p/v). Reivindicación 1: Una solución oftálmica acuosa caracterizada porque comprende dicuafosol o una sal de éste en una concentración de entre 0,1% y 10% (p/v) y un compuesto de clorhexidina en una concentración de entre 0,0001% y 0,1% (p/v). Reivindicación 2: La solución oftálmica acuosa del acuerdo con la reivindicación 1, caracterizada porque el compuesto de clorhexidina es el gluconato de clorhexidina. Reivindicación 8: La solución oftálmica acuosa de acuerdo con cualquiera de las reivindicaciones 1 a 7, caracterizada porque la concentración del dicuafosol o de la sal de este en la solución oftálmica es de 3% (p/v). Reivindicación 9: La solución oftálmica acuosa de acuerdo con cualquiera de las reivindicaciones 1 a 8, caracterizada porque también comprende un agente quelante. Reivindicación 10: La solución de acuerdo oftálmica acuosa de acuerdo con la reivindicación 9, caracterizada porque el agente quelante es el ácido etilendiaminotetraacético o una sal de éste. Reivindicación 18: Un método para prevenir una disminución en la proporción restante de un compuesto de clorhexidina en una solución oftálmica acuosa que comprende entre 0,1% y 10% (p/v) de dicuafosol o de una sal de este y un compuesto de clorhexidina, caracterizado porque comprende usar un compuesto de clorhexidina en una concentración de entre 0,0001% y 0,005% (p/v) para preparar la solución oftálmica acuosa. Reivindicación 19: Un método para estabilizar un compuesto de clorhexidina en una solución oftálmica acuosa que comprende entre 0,1% y 10% (p/v) de dicuafosol o de una sal de este y un compuesto de clorhexidina, caracterizado porque comprende controlar la concentración del compuesto de clorhexidina de manera tal que sea superior a 0,001% (p/v) e inferior a 0,1% (p/v).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014263003 | 2014-12-25 | ||
| JP2015114595 | 2015-06-05 | ||
| JP2016111473A JP6104433B2 (ja) | 2015-06-05 | 2016-06-03 | 水性点眼液 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR105199A1 true AR105199A1 (es) | 2017-09-13 |
Family
ID=56150716
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP160101981A AR105199A1 (es) | 2014-12-25 | 2016-06-29 | Soluciones oftálmicas acuosas |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10278985B2 (es) |
| JP (3) | JP6779614B2 (es) |
| KR (3) | KR101867791B1 (es) |
| AR (1) | AR105199A1 (es) |
| BR (1) | BR112017013841A2 (es) |
| CA (1) | CA2971689C (es) |
| EA (1) | EA034517B1 (es) |
| MX (1) | MX2017008277A (es) |
| MY (1) | MY182507A (es) |
| PH (1) | PH12017501096A1 (es) |
| SG (1) | SG11201705138QA (es) |
| TW (1) | TWI709405B (es) |
| WO (1) | WO2016104704A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6104433B2 (ja) * | 2015-06-05 | 2017-03-29 | 参天製薬株式会社 | 水性点眼液 |
| BR112017013841A2 (pt) * | 2014-12-25 | 2018-06-19 | Santen Pharmaceutical Co., Ltd. | solução oftálmica aquosa |
| WO2016195072A1 (ja) * | 2015-06-05 | 2016-12-08 | 参天製薬株式会社 | ソフトコンタクトレンズが装用されたドライアイ患者の眼に点眼されるように用いられることを特徴とするドライアイ治療剤 |
| KR20220163519A (ko) * | 2018-02-28 | 2022-12-09 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 및 양이온성 폴리머를 함유하는 안과용 조성물 |
| KR20240049646A (ko) * | 2019-08-27 | 2024-04-16 | 산텐 세이야꾸 가부시키가이샤 | 디쿠아포솔 또는 그 염 및 폴리비닐피롤리돈을 함유하는 수성 안과용 조성물 |
| US11229549B2 (en) * | 2019-09-18 | 2022-01-25 | Vance M. Thompson | Tear transplantation and multi-part contact lens with absorbent portion |
| WO2021261930A1 (ko) * | 2020-06-23 | 2021-12-30 | 주식회사태준제약 | 디쿠아포솔을 포함하는 점안 조성물 |
| KR102365008B1 (ko) | 2020-06-23 | 2022-02-23 | 주식회사태준제약 | 디쿠아포솔을 포함하는 점안 조성물 |
| KR102548710B1 (ko) | 2020-12-24 | 2023-06-28 | 주식회사 종근당 | 디쿠아포솔 또는 이의 약제학적으로 허용가능한 염과 토코페롤을 함유하는 건성안 예방 또는 치료용 약제학적 조성물 |
| JP7230169B2 (ja) * | 2020-12-25 | 2023-02-28 | 参天製薬株式会社 | ジクアホソルまたはその塩、銀塩およびイオン性等張化剤を含有する水性点眼液 |
| TW202408467A (zh) * | 2022-07-06 | 2024-03-01 | 日商樂敦製藥股份有限公司 | 眼科組成物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09301858A (ja) | 1996-05-13 | 1997-11-25 | Senju Pharmaceut Co Ltd | グルコン酸クロルヘキシジン安定化水性薬剤 |
| JPH10203960A (ja) * | 1997-01-24 | 1998-08-04 | Ofutekusu:Kk | 点眼液組成物 |
| JPH1160505A (ja) | 1997-05-20 | 1999-03-02 | Senju Pharmaceut Co Ltd | 防腐組成物 |
| JP2008222638A (ja) | 2007-03-13 | 2008-09-25 | Teika Seiyaku Kk | 油成分含有眼用組成物 |
| JP2009073788A (ja) | 2007-09-21 | 2009-04-09 | Teika Seiyaku Kk | イソプロピルウノプロストン含有眼用組成物 |
| JP5398452B2 (ja) * | 2008-09-30 | 2014-01-29 | 大正製薬株式会社 | 点眼剤 |
| JP5639409B2 (ja) * | 2009-08-07 | 2014-12-10 | ロート製薬株式会社 | シリコーンハイドロゲルコンタクトレンズ用眼科組成物 |
| JP6047272B2 (ja) | 2010-09-15 | 2016-12-21 | テイカ製薬株式会社 | 角膜上皮障害治療用点眼剤 |
| SG10201508591UA (en) * | 2010-12-28 | 2015-11-27 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol, method for producing the same, and method for inhibiting formation of insoluble precipitate |
| MY169816A (en) * | 2012-03-26 | 2019-05-16 | Santen Pharmaceutical Co Ltd | Ophthalmic solution comprising diquafosol |
| BR112017013841A2 (pt) * | 2014-12-25 | 2018-06-19 | Santen Pharmaceutical Co., Ltd. | solução oftálmica aquosa |
-
2015
- 2015-12-25 BR BR112017013841-7A patent/BR112017013841A2/pt not_active Application Discontinuation
- 2015-12-25 EA EA201791467A patent/EA034517B1/ru not_active IP Right Cessation
- 2015-12-25 TW TW104143787A patent/TWI709405B/zh active
- 2015-12-25 KR KR1020177029478A patent/KR101867791B1/ko active IP Right Grant
- 2015-12-25 MY MYPI2017000969A patent/MY182507A/en unknown
- 2015-12-25 KR KR1020187015734A patent/KR102330736B1/ko active IP Right Grant
- 2015-12-25 CA CA2971689A patent/CA2971689C/en active Active
- 2015-12-25 US US15/539,283 patent/US10278985B2/en active Active
- 2015-12-25 KR KR1020177014598A patent/KR101789019B1/ko active IP Right Grant
- 2015-12-25 MX MX2017008277A patent/MX2017008277A/es unknown
- 2015-12-25 WO PCT/JP2015/086230 patent/WO2016104704A1/ja active Application Filing
- 2015-12-25 JP JP2015253360A patent/JP6779614B2/ja active Active
- 2015-12-25 SG SG11201705138QA patent/SG11201705138QA/en unknown
-
2016
- 2016-06-29 AR ARP160101981A patent/AR105199A1/es unknown
-
2017
- 2017-06-13 PH PH12017501096A patent/PH12017501096A1/en unknown
-
2019
- 2019-03-13 US US16/351,661 patent/US10786526B2/en active Active
-
2020
- 2020-10-14 JP JP2020173120A patent/JP7128243B2/ja active Active
-
2022
- 2022-08-18 JP JP2022130503A patent/JP2022166223A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US10278985B2 (en) | 2019-05-07 |
| EA201791467A1 (ru) | 2017-11-30 |
| US10786526B2 (en) | 2020-09-29 |
| MX2017008277A (es) | 2017-10-02 |
| US20190209599A1 (en) | 2019-07-11 |
| KR101789019B1 (ko) | 2017-10-20 |
| TW201628626A (zh) | 2016-08-16 |
| JP2022166223A (ja) | 2022-11-01 |
| TWI709405B (zh) | 2020-11-11 |
| JP7128243B2 (ja) | 2022-08-30 |
| CA2971689C (en) | 2020-11-03 |
| SG11201705138QA (en) | 2017-07-28 |
| JP6779614B2 (ja) | 2020-11-04 |
| KR20170118255A (ko) | 2017-10-24 |
| JP2021008513A (ja) | 2021-01-28 |
| CA2971689A1 (en) | 2016-06-30 |
| KR20170067900A (ko) | 2017-06-16 |
| BR112017013841A2 (pt) | 2018-06-19 |
| WO2016104704A1 (ja) | 2016-06-30 |
| KR102330736B1 (ko) | 2021-11-23 |
| KR20180063381A (ko) | 2018-06-11 |
| JP2016210759A (ja) | 2016-12-15 |
| US20170348344A1 (en) | 2017-12-07 |
| MY182507A (en) | 2021-01-25 |
| KR101867791B1 (ko) | 2018-06-15 |
| PH12017501096A1 (en) | 2017-11-27 |
| EA034517B1 (ru) | 2020-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |