EA201490127A1 - Офтальмологический раствор, содержащий гиалуроновую кислоту или ее соль и пропиленгликоль - Google Patents

Офтальмологический раствор, содержащий гиалуроновую кислоту или ее соль и пропиленгликоль

Info

Publication number
EA201490127A1
EA201490127A1 EA201490127A EA201490127A EA201490127A1 EA 201490127 A1 EA201490127 A1 EA 201490127A1 EA 201490127 A EA201490127 A EA 201490127A EA 201490127 A EA201490127 A EA 201490127A EA 201490127 A1 EA201490127 A1 EA 201490127A1
Authority
EA
Eurasian Patent Office
Prior art keywords
salt
propylene glycol
hyaluronic acid
solution containing
concentration
Prior art date
Application number
EA201490127A
Other languages
English (en)
Other versions
EA025078B1 (ru
Inventor
Кодзи Инагаки
Тосихиро Огава
Йосихиде Хорибе
Ацуеси Дота
Такаси Нагано
Масацугу Накамура
Юитиро Накада
Original Assignee
Сантен Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сантен Фармасьютикал Ко., Лтд. filed Critical Сантен Фармасьютикал Ко., Лтд.
Publication of EA201490127A1 publication Critical patent/EA201490127A1/ru
Publication of EA025078B1 publication Critical patent/EA025078B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186—Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Ophthalmology & Optometry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Водный офтальмологический раствор, содержащий гиалуроновую кислоту или ее соль в концентрации от 0,03 до 0,5% (мас./об.) и пропиленгликоль в концентрации от 0,1 до 1,0% (мас./об.), который содержит в качестве единственного консерванта хлорид бензалкония в концентрации от 0,001 до 0,002% (мас./об.) и содержит ионное регулирующее тоничность средство в такой концентрации, что коэффициент осмотического давления офтальмологического раствора принимает значение от 0,9 до 1,1.
EA201490127A 2011-06-23 2012-06-22 Офтальмологический раствор, содержащий гиалуроновую кислоту или ее соль и пропиленгликоль EA025078B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011139566 2011-06-23
PCT/JP2012/065957 WO2012176865A1 (ja) 2011-06-23 2012-06-22 ヒアルロン酸またはその塩およびプロピレングリコールを含有する点眼液

Publications (2)

Publication Number Publication Date
EA201490127A1 true EA201490127A1 (ru) 2014-04-30
EA025078B1 EA025078B1 (ru) 2016-11-30

Family

ID=47422693

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201490127A EA025078B1 (ru) 2011-06-23 2012-06-22 Офтальмологический раствор, содержащий гиалуроновую кислоту или ее соль и пропиленгликоль

Country Status (16)

Country Link
US (1) US20140088039A1 (ru)
EP (1) EP2684560A4 (ru)
JP (1) JP5981783B2 (ru)
KR (1) KR101906631B1 (ru)
CN (1) CN103608000B (ru)
AU (2) AU2012274367A1 (ru)
BR (1) BR112013033060A2 (ru)
CA (1) CA2839822A1 (ru)
EA (1) EA025078B1 (ru)
GE (1) GEP20166459B (ru)
HK (1) HK1190089A1 (ru)
MX (1) MX345216B (ru)
MY (1) MY176112A (ru)
SG (1) SG10201605080VA (ru)
TW (2) TWI704931B (ru)
WO (1) WO2012176865A1 (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202114648A (zh) * 2015-03-06 2021-04-16 日商參天製藥股份有限公司 眼科用組成物
EP3395348A4 (en) * 2015-12-22 2019-08-14 NOF Corporation STABILIZER FOR LACRIMALE OILY LAYER AND EYE DROPS WITH IT
FR3063649B1 (fr) 2017-03-07 2021-05-21 Laboratoire De Rhumatologie Appliquee Nouvelle solution visco-elastique et son utilisation en rhumatologie
KR102268002B1 (ko) 2018-12-26 2021-06-23 (주)휴온스 효과 지속성 점안제 조성물
KR20230126522A (ko) * 2022-02-23 2023-08-30 주식회사 스카이테라퓨틱스 고분자 히알루론산의 구조체, 이의 제조방법 및 이를 포함하는 점안 조성물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322667A (en) * 1987-03-31 1994-06-21 Sherman Pharmaceuticals, Inc. Preservative system for ophthalmic and contact lens solutions and method for cleaning disinfecting and storing contact lenses
JPH01115902A (ja) 1987-10-30 1989-05-09 Showa Sangyo Co Ltd ヒアルロン酸の製造法
JP2530491B2 (ja) * 1988-12-20 1996-09-04 参天製薬株式会社 ヒアルロン酸点眼液
JPH1072376A (ja) * 1996-09-02 1998-03-17 Ofutekusu:Kk ヒアルロン酸含有点眼水溶液
US7147844B2 (en) * 1999-12-27 2006-12-12 Santen Pharmaceutical Co., Ltd. System for stabilizing lacrimal fluid layer
ES2330617T3 (es) * 2000-11-08 2009-12-14 Fxs Ventures, Llc Soluciones para lentes de contacto y lentes oftalmicas mejoradas que contienen sacaridos sencillos como potenciadores de conservantes.
JP2002193815A (ja) * 2000-12-25 2002-07-10 Ophtecs Corp 眼手術用角膜乾燥防止点眼剤
JP2003002837A (ja) * 2001-06-21 2003-01-08 Lion Corp 水性外用剤組成物及び液体組成物の白濁防止方法
JP4694773B2 (ja) * 2003-06-06 2011-06-08 ロート製薬株式会社 粘膜適用液状組成物
DK2486942T3 (en) * 2004-11-24 2019-01-28 Meda Pharmaceuticals Inc COMPOSITIONS CONTAINING AZELASTINE AND PROCEDURES FOR USING IT
CN1939534B (zh) * 2005-09-27 2010-12-01 长春金赛药业股份有限公司 含有人生长激素或人粒细胞巨噬细胞刺激因子的用于治疗损伤和溃疡的外用制剂
WO2007074904A1 (ja) * 2005-12-28 2007-07-05 Wakamoto Pharmaceutical Co., Ltd. 水性医薬組成物
CA2658646A1 (en) * 2006-07-25 2008-01-31 Osmotica Corp. Ophthalmic solutions
JPWO2008044734A1 (ja) * 2006-10-12 2010-02-18 杏林製薬株式会社 ガチフロキサシン含有水性液剤
JP2009161454A (ja) 2007-12-28 2009-07-23 Lion Corp 眼科用組成物
JP2009196903A (ja) 2008-02-19 2009-09-03 Lion Corp 眼科用組成物
EP2308468A1 (en) * 2009-10-08 2011-04-13 Novaliq GmbH Novel pharmaceutical composition comprising a macrolide immunosuppressant drug
JP5518608B2 (ja) * 2010-07-09 2014-06-11 ロート製薬株式会社 粘膜適用液状組成物

Also Published As

Publication number Publication date
MX345216B (es) 2017-01-18
AU2017203905B2 (en) 2019-07-11
MX2013015273A (es) 2014-04-14
CA2839822A1 (en) 2012-12-27
TWI704931B (zh) 2020-09-21
HK1190089A1 (zh) 2014-06-27
BR112013033060A2 (pt) 2017-01-24
JP2013028599A (ja) 2013-02-07
EA025078B1 (ru) 2016-11-30
NZ618822A (en) 2015-07-31
TW201309306A (zh) 2013-03-01
CN103608000B (zh) 2016-05-11
EP2684560A1 (en) 2014-01-15
AU2017203905A1 (en) 2017-06-29
AU2012274367A1 (en) 2014-01-23
KR20140041586A (ko) 2014-04-04
EP2684560A4 (en) 2014-08-06
US20140088039A1 (en) 2014-03-27
CN103608000A (zh) 2014-02-26
WO2012176865A1 (ja) 2012-12-27
SG10201605080VA (en) 2016-08-30
JP5981783B2 (ja) 2016-08-31
GEP20166459B (en) 2016-04-11
TW201742620A (zh) 2017-12-16
KR101906631B1 (ko) 2018-10-10
MY176112A (en) 2020-07-24

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU