RU2013137661A - Системы и методы оптимизации использования образца - Google Patents

Системы и методы оптимизации использования образца Download PDF

Info

Publication number
RU2013137661A
RU2013137661A RU2013137661/28A RU2013137661A RU2013137661A RU 2013137661 A RU2013137661 A RU 2013137661A RU 2013137661/28 A RU2013137661/28 A RU 2013137661/28A RU 2013137661 A RU2013137661 A RU 2013137661A RU 2013137661 A RU2013137661 A RU 2013137661A
Authority
RU
Russia
Prior art keywords
sample
container
microdoser
image
concentration
Prior art date
Application number
RU2013137661/28A
Other languages
English (en)
Other versions
RU2620922C2 (ru
Inventor
Ян ГИББОНС
Тони НУЖЕНТ
Энтони ДЕЛАКРУЗ
Дэниал ЯНГ
Элизабет ХОЛМС
Эндрю ДРЭЙК
Тимати Майкл КЕМП
Санни БАЛВАНИ
Чинмей ПАНГАРКАР
Original Assignee
Теранос, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Теранос, Инк. filed Critical Теранос, Инк.
Publication of RU2013137661A publication Critical patent/RU2013137661A/ru
Application granted granted Critical
Publication of RU2620922C2 publication Critical patent/RU2620922C2/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/07—Centrifugal type cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/42—Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B5/00—Other centrifuges
    • B04B5/04—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
    • B04B5/0407—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles
    • B04B5/0414—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes
    • B04B5/0421—Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers for liquids contained in receptacles comprising test tubes pivotably mounted
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/52—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving transaminase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/51—Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/59—Transmissivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00—Geometric image transformations in the plane of the image
    • G06T3/40—Scaling of whole images or parts thereof, e.g. expanding or contracting
    • G06T3/4084—Scaling of whole images or parts thereof, e.g. expanding or contracting in the transform domain, e.g. fast Fourier transform [FFT] domain scaling
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
    • H04N23/60—Control of cameras or camera modules
    • H04N23/64—Computer-aided capture of images, e.g. transfer from script file into camera, check of taken image quality, advice or proposal for image composition or decision on when to take image
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/40—Concentrating samples
    • G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
    • G01N2001/4083—Concentrating samples by other techniques involving separation of suspended solids sedimentation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00495—Centrifuges
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/62—Insulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91188—Transferases (2.) transferring nitrogenous groups (2.6)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96463—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30168—Image quality inspection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Theoretical Computer Science (AREA)
  • Endocrinology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Quality & Reliability (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Clinical Laboratory Science (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)

Abstract

1. Способ определения присутствия или концентрации анализируемого вещества в пробе текучей среды, находящейся в контейнере, включающий:(a) просвечивание контейнера вдоль первого участка, имеющего первую длину пути, для получения первого измерения интенсивности света, переданного вдоль первой длины пути;(b) перемещение пробы жидкости на другой участок в контейнере с другой длиной пути, если первое измерение окажется за пределами заранее определенного динамического диапазона переданной интенсивности света;(c) просвечивание контейнера вдоль другого участка для получения другого измерения интенсивности света, переданного через другую длину пути, и по выбору(d) повторение шагов (b) и (с), пока измерения интенсивности света не будут находиться в пределах заранее определенного динамического диапазона, определяя, таким образом, присутствие или концентрацию анализируемого вещества.2. Способ по п. 1, дополнительно включающий развертку линейно просканированного изображения, распознавая, таким образом, присутствие или концентрацию анализируемого вещества.3. Способ по п. 1, в котором проба перемещается из первого участка контейнера с первой длиной пути во второй участок контейнера с другой длиной пути, с помощью засасывания пробы.4. Способ по п. 3, в котором конец контейнера присоединен к пипетке, сконфигурированной для засасывания пробы.5. Способ по п. 3, в котором проба перемещается вверх или вниз по длине контейнера.6. Способ по п. 1, в котором контейнером является микродозатор.7. Способ по п. 1, в котором контейнер конической формы.8. Способ по п. 1, в котором у контейнера два открытых конца.9. Способ по п. 8, в котором диаметр перво

Claims (91)

1. Способ определения присутствия или концентрации анализируемого вещества в пробе текучей среды, находящейся в контейнере, включающий:
(a) просвечивание контейнера вдоль первого участка, имеющего первую длину пути, для получения первого измерения интенсивности света, переданного вдоль первой длины пути;
(b) перемещение пробы жидкости на другой участок в контейнере с другой длиной пути, если первое измерение окажется за пределами заранее определенного динамического диапазона переданной интенсивности света;
(c) просвечивание контейнера вдоль другого участка для получения другого измерения интенсивности света, переданного через другую длину пути, и по выбору
(d) повторение шагов (b) и (с), пока измерения интенсивности света не будут находиться в пределах заранее определенного динамического диапазона, определяя, таким образом, присутствие или концентрацию анализируемого вещества.
2. Способ по п. 1, дополнительно включающий развертку линейно просканированного изображения, распознавая, таким образом, присутствие или концентрацию анализируемого вещества.
3. Способ по п. 1, в котором проба перемещается из первого участка контейнера с первой длиной пути во второй участок контейнера с другой длиной пути, с помощью засасывания пробы.
4. Способ по п. 3, в котором конец контейнера присоединен к пипетке, сконфигурированной для засасывания пробы.
5. Способ по п. 3, в котором проба перемещается вверх или вниз по длине контейнера.
6. Способ по п. 1, в котором контейнером является микродозатор.
7. Способ по п. 1, в котором контейнер конической формы.
8. Способ по п. 1, в котором у контейнера два открытых конца.
9. Способ по п. 8, в котором диаметр первого открытого конца больше, чем второго открытого конца.
10. Способ по п. 1, в котором у контейнера имеется множество определенных вариантов ширины, чтобы осуществлять передачу света по множеству варьирующихся длин пути.
11. Способ по п. 1, в котором объем контейнера меньше 100 микролитров.
12. Способ по п. 1, в котором одновременно делаются снимки множества определенных длин пути.
13. Способ измерения концентрации анализируемого вещества в жидкой пробе, включающий:
(а) предоставление пробы, содержащейся в контейнере, размеры которого имеют множество вариантов определенной ширины, чтобы позволить передачу света по множеству длин пути, соответствующих определенным вариантам ширины;
(b) просвечивание контейнера вдоль по крайней мере одной из множества длин пути; и
(c) получение изображения контейнера для измерения первой интенсивности света, переданной вдоль указанного по крайней мере одного из множества длин пути для определения концентрации анализируемого вещества на основе измеренной первой интенсивности света.
14. Способ по п. 13, дополнительно включающий:
(a) получение изображения контейнера для измерения второй интенсивности света, передаваемого через другую длину пути, соответствующую другой определенной ширине контейнера;
(b) сравнение указанной первой интенсивности света и второй интенсивности света;
(c) определение концентрации анализируемого вещества, основываясь на указанном шаге сравнения.
15. Способ по п. 13, дополнительно включающий выбор желаемой длины пути по одному или более из следующих методов: (а) перемещение источника света по отношению к пробе, (b) перемещение детектора по отношению к пробе, или (с) перемещение пробы внутри контейнера по отношению к источнику света.
16. Способ по п. 13, в котором просвечивание от источника света, а получение изображения осуществляется детектором, при этом источник света и детектор находятся в противоположных сторонах контейнера.
17. Способ по п. 13, в котором просвечивание от источника света, а получение изображения осуществляется детектором, при этом источник света и детектор находятся на одной стороне контейнера.
18. Способ по п. 13, в котором множество длин пути являются ортогональными по отношению к длине контейнера.
19. Способ по п. 13, в котором у контейнера имеются первый открытый и второй открытый концы, и ширина первого открытого конца меньше, чем у второго открытого конца.
20. Способ по п. 19, в котором второй открытый конец сконфигурирован так, чтобы присоединить к нему устройство работы с жидкостью.
21. Автоматическая система разделения одного или более компонентов биологической жидкости, включающая:
(a) микродозатор или закрытую пробирку, приспособленную для работы с аспиратором, где упомянутые микродозатор или пробирка включают два противоположных конца, по крайней мере один из которых закрыт или загерметизирован; и
(b) центрифугу, сконфигурированную для работы с упомянутым микродозатором или закрытой пробиркой для выполнения указанного разделения одного или более компонентов в биологической жидкости.
22. Система по п. 21, в которой один или более компонентов выбраны из группы, состоящей из плазмы крови, сыворотки крови и твердых частиц.
23. Система по п. 21, в которой, когда микродозатор соединяется с аспиратором, выполняется забор биологической жидкости.
24. Система по п. 23, в которой микродозатор имеет открытый конец, который образует герметичное уплотнение с аспиратором.
25. Система по п. 21, дополнительно включающая
устройство получения изображений; и
размеры по крайней мере одного микродозатора достаточны для дозирования жидкости в микродозатор или пробирку с микродозатором (а) или достаточны для засасывания жидкости из микродозатора или пробирки с микродозатором (а).
26. Система по п. 21, в которой микродозатор или закрытая пробирка ориентированы вертикально, когда центрифуга находится в состоянии покоя.
27. Система по п. 26, в которой микродозатор или закрытая пробирка ориентированы горизонтально, когда центрифуга вращается с заранее определенной скоростью вращения.
28. Способ для отделения компонентов в пробе, включающий:
(a) загрузку пробы в микродозатор или пробирку, имеющие два противоположных конца, по крайней мере один из которых можно загерметизировать или он является загерметизированным;
(b) герметизацию микродозатора или пробирки на по крайней мере одном из концов микродозатора;
(c) центрифугирование загерметизированного микродозатора или пробирки, при котором формируется межфазный участок, где проба разделяется на надосадочный раствор и крупинки осадка;
(d) получение изображения отцентрифугированного микродозатора или пробирки для определения местоположения межфазного участка; и
(e) автоматический забор надосадочного раствора в зависимости от местоположения межфазного участка.
29. Способ по п. 28, дополнительно включающий определение местоположения надосадочной жидкости с помощью упомянутого шага получения изображения и автоматическое засасывание надосадочной жидкости в зависимости от местоположения надосадочной жидкости.
30. Способ по п. 29, в котором определение с помощью процессора, который задает инструкции устройству засасывания жидкости, которое автоматически выполняет шаг засасывания.
31. Способ по п. 28, в котором получение изображения осуществляют с помощью фотоаппарата, который сконфигурирован для снятия изображения вида сбоку микродозатора или пробирки.
32. Способ по п. 28, в котором надосадочная жидкость включает два или более из следующих веществ: плазмы крови или сыворотки крови.
33. Способ по п. 29, в котором крупинки осадка включают одно или более из следующих веществ: кровяные тельца или твердые частицы.
34. Способ характеристики анализируемого вещества, наличие которого предполагается в пробе, включающий:
(a) получение цифрового изображения пробы, которое включает по крайней мере двумерный массив элементов изображения, в котором каждый элемент включает множество значений интенсивности, каждому из которых соответствует отчетливое распознавание участка спектра;
(b) корреляцию с помощью программируемого устройства значений полученной интенсивности с заранее определенным набором значений, которые определяют динамический диапазон каждого распознаваемого участка спектра; и
(c) предсказание наличия и/или количества упомянутого анализируемого вещества в пробе на основании корреляции значений полученной интенсивности с заранее определенным набором значений.
35. Способ по п. 34, в котором множество значений интенсивности включает значения интенсивности для распознавания красного, зеленого и синего цветов на участках спектра.
36. Способ по п. 34, дополнительно включающий выбор длины волн для просвечивания и просвечивание пробы светом с выбранной длиной волны до и/или одновременно с получением цифрового изображения.
37. Способ по п. 36, дополнительно включающий: последующие шаги за получением цифрового изображения, (а) выбор другой длины волны для просвечивания; (b) просвечивание пробы светом с другой выбранной длиной волны; (с) получение другого цифрового изображения пробы, где цифровое изображение включает по крайней мере двухмерный массив элементов изображения и где каждый элемент включает множество значений интенсивности, каждому из которых соответствует отчетливое распознавание участка спектра; и (d) предсказание наличия и/или количества упомянутого анализируемого раствора в пробе на основании полученной из цифрового изображения и упомянутого другого цифрового изображения интенсивности значений.
38. Способ для характеристики анализируемого вещества, присутствие которого предполагается в пробе биологической жидкости, включающий:
(a) предоставление пробы биологической жидкости;
(b) предоставление возможности анализируемому веществу реагировать с одним или более реагентами, которые специфично взаимодействуют с упомянутым анализируемым веществом для генерирования оптически распознаваемого сигнала; и
(c) измерение упомянутого оптически распознаваемого сигнала при множестве распознаваемых участков спектра, где наличие упомянутого оптически распознаваемого сигнала в пределах динамического диапазона из по крайней мере одного распознаваемого участка спектра указывает на концентрацию упомянутого анализируемого вещества в упомянутой пробе биологической жидкости.
39. Способ по п. 38, в котором множество распознаваемых участков спектра выбирается из группы, состоящей из красного, зеленого и синего цветов.
40. Способ по п. 38, дополнительно включающий шаг по количественному расчету концентрации анализируемого вещества путем оценки значений, измеренных для по крайней мере одного распознаваемого участка спектра.
41. Способ по п. 38, в котором биологической жидкостью является кровь, моча, слюна, спинномозговая жидкость или семенная жидкость.
42. Способ по п. 38, в котором измерение выполняется с помощью устройства получения изображений, сконфигурированного для измерения множества распознаваемых участков спектра.
43. Способ по п. 42, в котором устройство получения изображений сконфигурировано для одновременного измерения множества распознаваемых участков спектра.
44. Способ по п. 42, в котором устройство получения изображений сконфигурировано для последовательного измерения множества распознаваемых участков спектра.
45. Способ по п. 38, в котором проба измеряется в микродозаторе.
46. Способ повышения надежности анализа, включающий:
(a) получение изображения в первом микродозаторе для определения объема первой пробы;
(b) получение изображения одного или более реагентов во втором микродозаторе для определения объема одного или более реагентов;
(c) смешивание пробы и одного или более реагентов для образования реакционной смеси;
(d) получение изображения реакционной смеси;
(e) калибровку, основаную на упомянутых определенных объемах пробы и одного или более реагентов; и
(f) расчет концентрации анализируемого вещества с использованием калибровки.
47. Способ по п. 46, дополнительно включающий получение изображения реакционной смеси для определения объема реакционной смеси.
48. Способ по п. 46, в котором получение изображения пробы в первом микродозаторе проводится с использованием фотоаппарата, сконфигурированного для снятия вида сбоку первого микродозатора.
49. Способ по п. 48, в котором получение изображения одного или более реагентов из второго микродозатора проводится с использованием фотоаппарата, сконфигурированного для снятия вида сбоку второго микродозатора.
50. Способ по п. 49, в котором высота пробы и одного или более реагентов рассчитывается на основании снятых боковых изображений.
51. Способ по п. 50, в котором определение объема основано на высоте пробы и одного или более реагентов, и участков пробы и одного или более реагентов, соответственно, в поперечном разрезе.
52. Способ по п. 47, в котором калибровка основана на определенном объеме реакционной смеси.
53. Автоматическая система для разделения одного или более компонентов биологической жидкости, включающая:
(a) центрифугу, состоящую из одного или более барабанов, предназначенную для приемки контейнера для выполнения указанного разделения одного или более компонентов в пробе жидкости; и
(b) контейнер, включающий одну или более деталей специальной формы, которая совмещается с формой барабана.
54. Система по п. 53, в которой один или более барабанов является шарнирным, то есть, может находиться у или близко к вертикальному положению, когда центрифуга находится в состоянии покоя, и у или близко к горизонтальному положению, когда центрифуга вращается.
55. Система по п. 54, дополнительно включающая множество шарнирных барабанов, которые располагаются симметрично в радиальном направлении.
56. Система по п. 53, в которой жидкая проба является биологической жидкостью.
57. Система по п. 56, в которой биологическая жидкость представляет собой это кровь.
58. Система по п. 53, в которой контейнер сконструирован для объема крови 100 мкл или менее.
59. Система по п. 53, в которой контейнер на одном конце закрыт и открыт на противоположном конце.
60. Система по п. 53, в которой контейнером является аппарат для центрифугирования.
61. Система по п. 60, в которой аппарат для центрифугирования имеет закругленный конец с одним или более внутренних утолщений.
62. Система по п. 60, дополнительно включающая экстракционный микродозатор с одной или более деталью особой формы, которая совмещается с формой детали на аппарате центрифугирования, и эта деталь сконструирована для вставки в аппарат центрифугирования.
63. Система по п. 53, в которой деталь особой формы в барабане включает одну или более полок, на которой, как сконструировано, может лежать выступающая часть контейнера.
64. Система по п. 53, в которой барабан выполнен так, чтобы можно было принимать множество контейнеров с различными формами, и в которой деталь с формами в барабане включает множество полок, где первый контейнер имеющий первую форму, настроен так, чтобы он шел на первую полку, а второй контейнер со второй формой настроен на вторую полку.
65. Установка, включающая:
аппарат, сконструированный для приемки и содержания пробы, где аппарат включает внутреннюю поверхность, наружную поверхность, открытый конец и противоположный закрытый конец; и
микродозатор, сконструированный для вхождения в аппарат через открытый конец, где микродозатор включает первый открытый конец, и где второй открытый конец вставляется в аппарат,
где аппарат или микродозатор дополнительно включает выступающую деталь поверхности, которая не дает второму открытому концу микродозатора касаться дна внутренней поверхности закрытого конца аппарата.
66. Установка по п. 65, в которой деталь поверхности образует единое целое на дне внутренней поверхности аппарата.
67. Установка по п. 65, в которой деталь поверхности включает множество утолщений на дне внутренней поверхности аппарата.
68. Установка по п. 65, в которой выступающая деталь поверхности находится у или близко к закрытому концу.
69. Аппаратура для обработки проб, включающая:
станцию приготовления пробы, станцию анализа, и/или станцию детекции;
блок управления, выдающий команды, выполняемые компьютером для проведения технических операций в заданном месте с помощью по крайней мере одной из упомянутых - станции приготовления проб, станции анализа и станции детекции; и
по крайней мере одну центрифугу, сконструированную для центрифугирования пробы из капилляра.
70. Аппаратура по п. 69, в которой центрифуга находится внутри станции приготовления проб и/или станции анализа.
71. Аппаратура по п. 70, в которой команды, выполняемые компьютером, сконфигурированы для проведения технических операций по месту, выбранному из группы, состоящей из места компании по розничной торговле, дома пациента или учреждения для проверки здоровья/лечения.
72. Способ для динамичной обратной связи, включающий:
снятие первоначального показания пробы внутри контейнера с использованием механизма детекции;
основываясь на указанном первоначальном показании, определение с помощью процессора, находится ли концентрация пробы в пределах желаемого диапазона, и определение с использованием процессора (а) степени разбавления, которой нужно достичь, если концентрация пробы выше, чем желаемый диапазон или (b) уровня концентрации, которого нужно достичь, если концентрация пробы ниже желаемого диапазона; и
регулирование концентрации пробы в соответствии с определенной степенью разбавления или определенным уровнем концентрации.
73. Способ по п. 72, дополнительно включающий последующее измерение пробы внутри контейнера.
74. Способ по п. 73, дополнительно включающий, основываясь на последующих измерениях, определение с помощью процессора, находится ли концентрация пробы в пределах желаемого диапазона.
75. Способ по п. 74, в котором последующее измерение выполняют с использованием механизма детекции.
76. Способ по п. 73, дополнительно включающий определение характеристики пробы, основываясь на последующем измерении.
77. Способ по п. 76, в котором характеристика выбрана из одного или более следующих факторов: наличие или концентрация анализируемого вещества, наличие или концентрация тельца и морфология тельца.
78. Способ по п. 77, в котором последующее измерение выполняют с использованием отдельного от первоначального механизма детекции.
79. Способ по п. 73, в котором первоначальное измерение представляет приблизительную концентрацию телец в пробе.
80. Способ по п. 79, в котором последующее измерение представляет концентрацию телец в пробе с большей разрешающей способностью, чем у первоначального измерения.
81. Способ по п. 72, в котором первоначальное измерение выполняют с помощью снятия изображения пробы.
82. Способ по п. 72, в котором регулирование концентрации пробы дает возможность распознавать анализируемое вещество, распознавание которого в другом случае было бы за пределами желаемого диапазона.
83. Способ контроля качества, включающий:
снятие изображения условий, при которых механизм детекции измеряет характеристику пробы, и
определение с использованием процессора, основываясь на изображении, есть ли нежелательные условия, при которых механизм работает.
84. Способ по п. 83, в котором нежелательные условия включают присутствие одного или более нежелательных материалов.
85. Способ по п. 84, в котором нежелательные материалы включают одно или боле из следующих: пузырьки, частицы, волокна, мусор и осадки, которые мешают измерению характеристики пробы.
86. Способ по п. 83, в котором механизм детекции отличается от механизма, используемого для получения изображений.
87. Способ по п. 83, в котором изображение получено с помощью фотоаппарата.
88. Способ по п. 83, дополнительно включающий уведомление о зафиксированном нежелательном условии.
89. Способ по п. 83, дополнительно включающий корректировку пробы, если зафиксировано нежелательное условие.
90. Способ по п. 83, в котором изображение включает изображение пробы.
91. Способ по п. 90, в котором изображение включает один или более из следующих предметов: контейнер с пробой или механизм распознавания.
RU2013137661A 2011-01-21 2012-01-20 Системы и методы оптимизации использования образца RU2620922C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161435250P 2011-01-21 2011-01-21
US61/435,250 2011-01-21
PCT/US2012/022130 WO2012100235A2 (en) 2011-01-21 2012-01-20 Systems and methods for sample use maximization

Publications (2)

Publication Number Publication Date
RU2013137661A true RU2013137661A (ru) 2015-02-27
RU2620922C2 RU2620922C2 (ru) 2017-05-30

Family

ID=46516422

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2013137661A RU2620922C2 (ru) 2011-01-21 2012-01-20 Системы и методы оптимизации использования образца

Country Status (18)

Country Link
US (8) US20120309636A1 (ru)
EP (2) EP4024029A3 (ru)
JP (4) JP5945282B2 (ru)
KR (1) KR101909764B1 (ru)
CN (7) CN106290159A (ru)
AR (1) AR085087A1 (ru)
AU (1) AU2012207090B2 (ru)
BR (1) BR112013018656B1 (ru)
CA (2) CA2825196C (ru)
ES (1) ES2895518T3 (ru)
HK (1) HK1232292A1 (ru)
IL (1) IL227579B (ru)
MX (2) MX2013008339A (ru)
RU (1) RU2620922C2 (ru)
SG (2) SG10201600463YA (ru)
TW (4) TWI690594B (ru)
WO (1) WO2012100235A2 (ru)
ZA (1) ZA201305478B (ru)

Families Citing this family (203)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008041900A1 (en) * 2006-10-06 2008-04-10 Boule Medical Ab Device for extraction of a partial defined sample volume from a lager volume, method for operating the device, set of at least two devices, method of operation the set, an analytical instrument connectable to the device, method for operating the instrument, a system, and a method for operating the system
DK2657699T3 (en) 2007-10-02 2017-07-10 Theranos Inc Modular point-of-care devices and their applications
US8493441B2 (en) * 2009-09-11 2013-07-23 Thonhauser Gmbh Absorbance measurements using portable electronic devices with built-in camera
CN106290159A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
US9646375B2 (en) 2011-07-09 2017-05-09 Gauss Surgical, Inc. Method for setting a blood transfusion parameter
US9936906B2 (en) 2012-05-14 2018-04-10 Gauss Surgical, Inc. System and methods for managing blood loss of a patient
US9870625B2 (en) 2011-07-09 2018-01-16 Gauss Surgical, Inc. Method for estimating a quantity of a blood component in a fluid receiver and corresponding error
US8792693B2 (en) 2011-07-09 2014-07-29 Gauss Surgical System and method for estimating extracorporeal blood volume in a physical sample
US10426356B2 (en) 2011-07-09 2019-10-01 Gauss Surgical, Inc. Method for estimating a quantity of a blood component in a fluid receiver and corresponding error
US9047663B2 (en) 2011-07-09 2015-06-02 Gauss Surgical Method for triggering blood salvage
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9810704B2 (en) * 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
WO2014138137A2 (en) 2013-03-04 2014-09-12 Theranos, Inc. Network connectivity methods and systems
CN109738621B (zh) * 2012-05-14 2021-05-11 高斯外科公司 用于估计液体罐中的血液成分的量的系统和方法
FR2991457B1 (fr) * 2012-06-01 2014-07-18 Commissariat Energie Atomique Procede et systeme de caracterisation de la vitesse de deplacement de particules contenues dans un liquide, telles que des particules sanguines
US9506935B2 (en) * 2012-06-01 2016-11-29 Commissariat à l'énergie atomique et aux énergies alternatives Method and system for estimating the quantity of an analyte contained in a liquid
US9389229B2 (en) * 2012-07-18 2016-07-12 Theranos, Inc. Methods for detecting and measuring aggregation
SG11201500343VA (en) 2012-07-18 2015-02-27 Theranos Inc High speed, compact centrifuge for use with small sample volumes
CA2878872A1 (en) 2012-07-18 2014-01-23 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes
US9500639B2 (en) 2012-07-18 2016-11-22 Theranos, Inc. Low-volume coagulation assay
US8984932B2 (en) 2012-07-18 2015-03-24 Theranos, Inc. Rapid measurement of formed blood component sedimentation rate from small sample volumes
WO2014018805A2 (en) 2012-07-25 2014-01-30 Theranos,Inc. Image analysis and measurement of biological samples
CN104955957B (zh) * 2012-12-11 2019-01-11 普凯尔德诊断技术有限公司 具有弯曲底部的光学杯
US10401373B1 (en) 2013-02-18 2019-09-03 Theranos Ip Company, Llc Systems and methods for analyte testing and laboratory oversight
US11008628B1 (en) 2013-02-18 2021-05-18 Labrador Diagnostics Llc Systems and methods for analyte testing and laboratory oversight
US9839921B2 (en) * 2013-03-14 2017-12-12 Sisu Global Health, Inc. Modular centrifuge devices and methods
KR101504819B1 (ko) * 2013-05-03 2015-03-23 동국대학교 산학협력단 원심분리용 용기
WO2014186874A1 (en) * 2013-05-23 2014-11-27 Yyz Pharmatech, Inc. Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay
US10422806B1 (en) 2013-07-25 2019-09-24 Theranos Ip Company, Llc Methods for improving assays of biological samples
EP3674422A3 (en) 2013-09-06 2020-09-16 Labrador Diagnostics LLC Systems and methods for detecting infectious diseases
EP3042196A4 (en) 2013-09-06 2017-04-05 Theranos, Inc. Devices, systems, methods and kits for receiving a swab
US11545241B1 (en) * 2013-09-07 2023-01-03 Labrador Diagnostics Llc Systems and methods for analyte testing and data management
WO2015066342A1 (en) 2013-11-04 2015-05-07 Siemens Healthcare Diagnostics Inc. Methods and apparatus for determining aspiration and/or dispensing volume and/or pipette positioning
US11360107B1 (en) * 2014-02-25 2022-06-14 Labrador Diagnostics Llc Systems and methods for sample handling
US9959477B2 (en) * 2014-03-03 2018-05-01 The Board Of Trustees Of The Leland Stanford Junior University Mapping of blood vessels for biometric authentication
US10338004B2 (en) * 2014-03-27 2019-07-02 KLA—Tencor Corp. Production sample shaping that preserves re-normalizability
CN104289259A (zh) * 2014-03-29 2015-01-21 浙江清华长三角研究院萧山生物工程中心 一种基于机器视觉的移液器校准方法
US9773320B2 (en) 2014-04-15 2017-09-26 Gauss Surgical, Inc. Method for estimating a quantity of a blood component in a fluid canister
EP3132380B1 (en) 2014-04-15 2020-10-14 Gauss Surgical, Inc. Method for estimating a quantity of a blood component in a fluid canister
US10226566B2 (en) * 2014-04-23 2019-03-12 Genadyne Biotechnologies, Inc. System and process for removing bodily fluids from a body opening
JP6637962B2 (ja) 2014-04-24 2020-01-29 ルシラ ヘルス インコーポレイテッド 核酸増幅の比色検出方法
EP3142796A4 (en) * 2014-05-16 2017-12-20 Qvella Corporation Apparatus, system and method for performing automated centrifugal separation
JP6628743B2 (ja) 2014-06-03 2020-01-15 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ナノ粒子分析システム及び方法
EP3175022B1 (en) * 2014-07-28 2020-09-16 Sanofi Pasteur VaxDesign Corporation Automated imaging and analysis of the hemagglutination inhibition assay (hai)
US9547899B1 (en) * 2014-10-07 2017-01-17 University Of South Florida Mobile hemolysis detection in whole blood samples
US9976881B2 (en) * 2014-12-04 2018-05-22 Cnh Industrial Canada, Ltd. System and method for analyzing product flow signal for an agricultural implement
CN107407629B (zh) * 2015-03-05 2020-09-01 生物辐射实验室股份有限公司 优化的光谱匹配和显示
US10279352B2 (en) * 2015-03-18 2019-05-07 Optolane Technologies Inc. PCR module, PCR system having the same, and method of inspecting using the same
WO2016176629A1 (en) * 2015-04-29 2016-11-03 Ixcela, Inc. Methods and devices for quantitating blood samples
US20160335765A1 (en) * 2015-05-12 2016-11-17 Justus W. Harris Three dimensional modeling of health data
US11504037B2 (en) 2015-05-15 2022-11-22 Gauss Surgical, Inc. Systems and methods for assessing fluids from a patient
WO2016187072A1 (en) 2015-05-15 2016-11-24 Gauss Surgical, Inc. Methods and systems for characterizing fluids from a patient
US10555675B2 (en) 2015-05-15 2020-02-11 Gauss Surgical, Inc. Method for projecting blood loss of a patient during a surgery
CN106248434A (zh) * 2015-05-19 2016-12-21 亚诺法生技股份有限公司 液体采集装置及制作液体采集装置的方法
US9774838B2 (en) * 2015-06-12 2017-09-26 Accuray Incorporated Ambient light suppression using color space information to derive pixel-wise attenuation factors
EP3136106A1 (de) * 2015-08-28 2017-03-01 Siemens Healthcare Diagnostics Products GmbH Photometrische analyse einer probenflüssigkeit
EP3350573B1 (en) * 2015-09-04 2021-06-16 Qualigen, Inc. Systems and methods for sample verification
US10012580B2 (en) * 2015-10-14 2018-07-03 MANTA Instruments, Inc. Apparatus and method for measurements of growth or dissolution kinetics of colloidal particles
WO2017066487A1 (en) * 2015-10-14 2017-04-20 Manta Instructions, Inc. Apparatus and method for measurements of growth or dissolution kinetics of colloidal particles
CN106885910B (zh) * 2015-12-15 2018-12-21 上海吉涛生物科技有限公司 肿瘤易感微环境检测装置及试剂盒
JP6968427B2 (ja) 2015-12-23 2021-11-17 ガウス サージカル, インコーポレイテッドGauss Surgical, Inc. ある体積の流体における血液成分の量を推定するためのシステム及び方法
WO2017112939A1 (en) 2015-12-23 2017-06-29 Gauss Surgical, Inc. Method for estimating blood component quantities in surgical textiles
US10311569B1 (en) * 2015-12-31 2019-06-04 Cerner Innovation, Inc. Identifying liquid blood components from sensed data to monitor specimen integrity
US10267813B1 (en) * 2015-12-31 2019-04-23 Cerner Innovation, Inc. Monitoring specimen integrity in automated blood sample processing system
US10527635B1 (en) 2015-12-31 2020-01-07 Cerner Innovation, Inc. Specimen integrity monitoring device for automated blood sample processing systems
US10209267B1 (en) 2015-12-31 2019-02-19 Cerner Innovation, Inc. Sample extraction and rotation device for automated blood sample processing systems
EP3408653B1 (en) * 2016-01-28 2024-01-17 Siemens Healthcare Diagnostics Inc. Methods and apparatus adapted to quantify a specimen from multiple lateral views
EP3408652B1 (en) * 2016-01-28 2020-12-16 Siemens Healthcare Diagnostics Inc. Methods and apparatus for classifying an artifact in a specimen
EP3408651B1 (en) * 2016-01-28 2024-01-10 Siemens Healthcare Diagnostics Inc. Methods and apparatus for detecting an interferent in a specimen
EP3408641B1 (en) 2016-01-28 2021-05-26 Siemens Healthcare Diagnostics Inc. Methods and apparatus for multi-view characterization
FR3048505A1 (fr) * 2016-03-04 2017-09-08 Novacyt Comptage cellules photographies
WO2017160839A1 (en) 2016-03-14 2017-09-21 Diassess Inc. Devices and methods for modifying optical properties
EP3429543A4 (en) 2016-03-14 2019-11-06 Lucira Health, Inc. BIOLOGICAL ANALYSIS DEVICES WITH SELECTIVE VENTILATION AND ASSOCIATED METHODS
AU2017232342B2 (en) 2016-03-14 2022-04-21 Pfizer Inc. Devices and methods for biological assay sample preparation and delivery
WO2017160836A1 (en) 2016-03-14 2017-09-21 Diassess Inc. Systems and methods for performing biological assays
US10690590B2 (en) * 2016-04-05 2020-06-23 Viavi Solutions Inc. Light pipe for spectroscopy
US10318845B2 (en) * 2016-04-14 2019-06-11 Research International, Inc. Coupon reader
TWI569861B (zh) * 2016-04-22 2017-02-11 國立高雄大學 血液吸附分離材料、血液過濾裝置及其操作方法
CN107403220A (zh) * 2016-04-28 2017-11-28 明达医学科技股份有限公司 光学量测装置及其运作方法
EP3465612A4 (en) * 2016-05-27 2020-02-26 Biomerieux, Inc METHOD AND DEVICE FOR DETECTING FOAM IN SAMPLE CONTAINERS
WO2017223401A1 (en) * 2016-06-24 2017-12-28 Kobra Biosolutions, Llc Verification pipette and vision apparatus
US10132958B2 (en) * 2016-07-14 2018-11-20 Schlumberger Technology Corporation Determining an optical density linear dynamic range for an optical spectrometer
US10989724B1 (en) 2016-07-29 2021-04-27 Labrador Diagnostics Llc Systems and methods for multi-analysis
US10690583B2 (en) * 2016-09-12 2020-06-23 Sony Corporation Microparticle measuring device and microparticle measuring method
EP3944144A1 (en) 2016-10-28 2022-01-26 Beckman Coulter, Inc. Substance preparation evaluation system
US10345218B2 (en) 2016-12-06 2019-07-09 Abbott Laboratories Automated slide assessments and tracking in digital microscopy
WO2018125812A1 (en) 2017-01-02 2018-07-05 Gauss Surgical, Inc. Tracking surgical items with prediction of duplicate imaging of items
US11439310B2 (en) 2017-01-11 2022-09-13 Cypher Medical, Llc Method of estimating blood volume
CN116473523A (zh) 2017-01-11 2023-07-25 赛弗医疗有限责任公司 估测血量的方法
US11229368B2 (en) 2017-01-13 2022-01-25 Gauss Surgical, Inc. Fluid loss estimation based on weight of medical items
US10551320B2 (en) * 2017-01-30 2020-02-04 Kla-Tencor Corporation Activation of wafer particle defects for spectroscopic composition analysis
WO2018148609A2 (en) * 2017-02-09 2018-08-16 Essenlix Corporation Colorimetric assays
US10471425B2 (en) 2017-02-16 2019-11-12 International Business Machines Corporation Automated machine for sorting of biological fluids
CN110402383B (zh) 2017-03-08 2023-01-17 奥普图弗卢迪克生物鉴定有限责任公司 光流控诊断系统
EP3381560A1 (de) * 2017-03-28 2018-10-03 Eppendorf AG Verfahren und dosiervorrichtung zum kontaktdosieren von flüssigkeiten
US11080848B2 (en) 2017-04-06 2021-08-03 Lucira Health, Inc. Image-based disease diagnostics using a mobile device
US10146909B2 (en) * 2017-04-06 2018-12-04 Diassess Inc. Image-based disease diagnostics using a mobile device
CN110573859B (zh) * 2017-04-13 2022-07-26 美国西门子医学诊断股份有限公司 用于使用卷积神经网络的hiln表征的方法和装置
CN106932362A (zh) * 2017-04-26 2017-07-07 上海健康医学院 一种血清中尿素氮肌酐含量近红外光谱测定方法
CN106908411A (zh) * 2017-04-26 2017-06-30 上海健康医学院 一种血清中尿素氮含量近红外光谱测定方法
WO2018213562A1 (en) * 2017-05-17 2018-11-22 University Of Cincinnati Using electrokinetic forces to manipulate suspended particles
FR3067814A1 (fr) * 2017-06-20 2018-12-21 Biomerieux Procede d'application, sur un support solide, d'au moins un partenaire de liaison a une molecule
US11657593B2 (en) 2017-07-28 2023-05-23 Siemens Healthcare Diagnostics Inc. Deep learning volume quantifying methods and apparatus
DE102018106751A1 (de) * 2017-07-31 2019-01-31 Taiwan Semiconductor Manufacturing Co. Ltd. Automatisiertes inspektionswerkzeug
US11207036B2 (en) * 2017-08-16 2021-12-28 KUB Technologies, Inc. System and method for cabinet x-ray systems with automatic specimen/sample alert
WO2019049395A1 (ja) * 2017-09-08 2019-03-14 アルフレッサファーマ株式会社 分析装置および分析方法
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
US11199449B1 (en) * 2017-09-26 2021-12-14 The United States Of America, As Represented By The Secretary Of The Navy Automated noncontact method to discriminate whether cooling or heating is occurring
JP6519624B2 (ja) * 2017-10-04 2019-05-29 ウシオ電機株式会社 管理システム
CA2981726C (en) * 2017-10-06 2018-12-04 Synaptive Medical (Barbados) Inc. Surgical optical zoom system
US11668711B2 (en) * 2017-11-13 2023-06-06 Cornell Univeristy Multiplexed diagnostic assay for iron and vitamin A deficiency and methods of use thereof
EP3710598A1 (en) * 2017-11-13 2020-09-23 Ricoh Company, Ltd. Device with specific number of cell(s) and nucleic acids in the wells and testing/calibration method using the device
CN107832967B (zh) * 2017-11-23 2021-09-14 福建农林大学 一种适用于竹林空间的声景协调度动态评价方法
JP7232843B2 (ja) * 2018-01-09 2023-03-03 アイデックス ラボラトリーズ インコーポレイテッド 生体試料中の分析物および／またはタンパク質を測定するための方法
CN111630383A (zh) * 2018-01-11 2020-09-04 东洋纺株式会社 测定试样稀释液及试剂盒及测定方法
US11358148B2 (en) 2018-03-30 2022-06-14 Idexx Laboratories, Inc. Point-of-care diagnostic systems and containers for same
US11541396B2 (en) 2018-03-30 2023-01-03 Idexx Laboratories, Inc. Point-of-care diagnostic systems and containers for same
WO2019191531A1 (en) * 2018-03-30 2019-10-03 Idexx Laboratories, Inc. Quality control for point-of-care diagnostic systems
KR102577993B1 (ko) * 2018-04-06 2023-09-18 프리시젼바이오 주식회사 유체 검사 카트리지, 이를 포함하는 유체 검사장치 및 검사장치의 제어방법
JP2019191169A (ja) * 2018-04-23 2019-10-31 ブルカー ジェイヴィ イスラエル リミテッドＢｒｕｋｅｒ Ｊｖ Ｉｓｒａｅｌ Ｌｔｄ． 小角ｘ線散乱測定用のｘ線源光学系
US11712549B2 (en) 2018-06-28 2023-08-01 Kinneret Rand Anti-clogging and anti-adhesive micro-capillary needle with enhanced tip visibility
WO2020014190A1 (en) * 2018-07-09 2020-01-16 Sandstone Diagnostics, Inc. Devices and methods for plasma separation and storage
JP7421192B2 (ja) * 2018-07-17 2024-01-24 国立大学法人神戸大学 攪拌装置及び前処理装置
US11262352B2 (en) 2018-07-20 2022-03-01 Cornell University Magnetic separation of biological entities from fluid sample
CN109061016A (zh) * 2018-07-25 2018-12-21 大连工业大学 一种富集生物胺的固相萃取柱的制备方法与应用
US11703464B2 (en) 2018-07-28 2023-07-18 Bruker Technologies Ltd. Small-angle x-ray scatterometry
EP3833962A4 (en) * 2018-08-06 2022-01-05 Siemens Healthcare Diagnostics Inc. METHOD, DEVICE AND SYSTEM FOR DETERMINING THE CONCENTRATION OF ANALYTES IN A SAMPLE
EP3614151B1 (en) * 2018-08-20 2023-07-19 F. Hoffmann-La Roche AG Method of operating a laboratory instrument
US11406981B2 (en) 2018-08-22 2022-08-09 Biomerieux, Inc. Detection instruments with automated cell location selection for newly intaken specimen containers and related methods
CN109211624B (zh) * 2018-09-10 2023-11-28 佛山科学技术学院 一种防水的氨挥发采集装置
JP7201297B2 (ja) * 2018-09-26 2023-01-10 シスメックス株式会社 フローサイトメーター、データ送信方法及び情報処理システム
CA3115732A1 (en) * 2018-10-31 2020-05-07 Foundation For Research And Technology Hellas Method and apparatus for performing a real-time colorimetric nucleic acid amplification assay
TWI668425B (zh) * 2018-11-05 2019-08-11 林瑞陽 微粒辨識計數方法及分析裝置
US11386551B2 (en) * 2018-11-08 2022-07-12 Perkinelmer Health Sciences, Inc. Method and apparatus for buffy coat imaging
USD910200S1 (en) 2018-12-21 2021-02-09 Lucira Health, Inc. Test tube
CN111374714B (zh) * 2018-12-29 2021-10-08 重庆西山科技股份有限公司 样本保持器的腔室选择方法及活检装置
US20220074845A1 (en) * 2019-01-03 2022-03-10 Pixcell Medical Technologies Ltd. Systems and methods for analyzing a fluid sample
CN113874705B (zh) * 2019-01-07 2024-04-16 1866402安大略有限公司 血液分离及分析装置和方法
CN109799338B (zh) * 2019-01-14 2022-02-11 湖南达道生物工程有限公司 一种适用于末梢血免疫层析定量检测的试纸及其应用
CN113614532A (zh) * 2019-01-16 2021-11-05 烟台澳斯邦生物工程有限公司 沉积用于显微镜检查的生物样品的自动液体处理系统和方法
JP7253396B2 (ja) * 2019-01-25 2023-04-06 株式会社ディスコ 検査装置
US11460476B2 (en) * 2019-03-04 2022-10-04 Siemens Healthcare Diagnostics Inc. Dye-based liquid reagent volume indicator for use in analyte detection assays
JP6817549B2 (ja) * 2019-03-06 2021-01-20 ウシオ電機株式会社 管理システム
US11964092B2 (en) * 2019-03-11 2024-04-23 ABC Med Tech Corp. Portable centrifuge and method of use
JP7164927B2 (ja) * 2019-03-19 2022-11-02 株式会社日立製作所 デジタルｐｃｒ計測装置
TWI696496B (zh) * 2019-05-03 2020-06-21 國立臺灣大學 手動離心裝置、具該裝置之系統及分離血液之方法
CN113826170A (zh) * 2019-05-17 2021-12-21 私募蛋白质体公司 控制复杂生物基质中的样品间分析物可变性
EP3751289A1 (de) * 2019-06-13 2020-12-16 Siemens Healthcare Diagnostics Products GmbH Vorrichtung zur optischen überwachung einer dosierung einer zu pipettierenden flüssigkeit
EP3757547B1 (en) * 2019-06-28 2022-11-23 ABB Schweiz AG Turbidity calibration-correction apparatus and method for an automated calibration correction
DE102019118171A1 (de) * 2019-07-04 2021-01-07 Endress+Hauser Conducta Gmbh+Co. Kg Verfahren zum Betreiben eines automatischen Analysegeräts und ein automatisches Analysegerät
US11668723B2 (en) 2019-07-09 2023-06-06 Logan Instruments Corporation Automated dissolution/permeation testing system
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
WO2021035211A1 (en) * 2019-08-22 2021-02-25 Applikate Technologies Llc Tissue processing
US11327084B2 (en) * 2019-09-19 2022-05-10 Invidx Corp. Joint hematology and biochemistry point-of-care testing system
CN110542686A (zh) * 2019-09-30 2019-12-06 广东牧玛生命科技有限公司 一种多功能分析仪器
JP7573605B2 (ja) * 2019-10-17 2024-10-25 ノヴァ バイオメディカル コーポレイション 凝血アッセイ装置およびその方法
CN110672525B (zh) * 2019-10-23 2022-03-11 成都信息工程大学 一种溶液浓度测量装置、方法及溶液传感灵敏度测量方法
CN114585927A (zh) * 2019-10-31 2022-06-03 美国西门子医学诊断股份有限公司 针对样本和/或样本容器表征提供背景照明校准的方法和设备
JP2023500678A (ja) * 2019-11-05 2023-01-10 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド 検体を分析するシステム、装置、および方法
CN110929282A (zh) * 2019-12-05 2020-03-27 武汉深佰生物科技有限公司 一种基于蛋白互作的生物特征信息预警方法
FR3104772B1 (fr) * 2019-12-13 2023-04-21 Idemia Identity & Security France Terminal d’analyse de document et procédé d’analyse de document
CN110879159B (zh) * 2019-12-27 2022-11-15 长安大学 一种高温高湿度气溶胶采样装置及采样方法
CN111147775B (zh) * 2020-01-03 2022-07-08 中国电子科技集团公司第四十四研究所 一种单片混合型ccd结构
CN111089953A (zh) * 2020-01-22 2020-05-01 马新国 一种尿液检测装置
US11520775B2 (en) * 2020-01-24 2022-12-06 Sartorius Bioanalytical Instruments, Inc. Adaptive data sub-sampling and computation
USD953561S1 (en) 2020-05-05 2022-05-31 Lucira Health, Inc. Diagnostic device with LED display
CN111521591B (zh) * 2020-05-09 2021-04-16 艾普拜生物科技(苏州)有限公司 用于微滴式数字pcr仪的计数校准装置、制备及使用方法
WO2021231504A1 (en) * 2020-05-12 2021-11-18 Rpi Consulting Llc Systems and methods for isolating and testing blood for biomarkers and genetic material
CN111624350A (zh) * 2020-05-25 2020-09-04 迪瑞医疗科技股份有限公司 可溶性转铁蛋白受体化学发光免疫检测试剂盒及其制备方法
USD962470S1 (en) 2020-06-03 2022-08-30 Lucira Health, Inc. Assay device with LCD display
US20220020455A1 (en) * 2020-07-14 2022-01-20 Talis Biomedical Corporation Point-of-care diagnostic instrument workflow
CN112229754B (zh) * 2020-09-29 2022-01-28 西南石油大学 一种迭代平均法计算甲烷在页岩中吸附量的方法
WO2022076920A1 (en) * 2020-10-08 2022-04-14 Essenlix Corporation Assay error reduction
EP3995808B1 (de) * 2020-11-09 2023-01-04 Siltronic AG Verfahren zum klassifizieren von unbekannten partikeln auf einer oberfläche einer halbleiterscheibe
CN112558115B (zh) * 2020-11-30 2023-10-10 中航机载系统共性技术有限公司 一种基于自适应bfo-pso改进粒子滤波的卫星raim监测方法
US20220187205A1 (en) * 2020-12-15 2022-06-16 Quantum-Si Incorporated Systems and methods for chip regeneration
CN112924421A (zh) * 2021-01-28 2021-06-08 重庆邮电大学 一种核酸适配体传感器的共振光散射检测分析方法及检测装置
CN113188605B (zh) * 2021-05-12 2022-06-21 郑州大学 一种基于智能手机的物理实验方法
CN113252852B (zh) * 2021-06-04 2021-10-22 金科环境股份有限公司 絮凝剂性能评价与检验设备及方法
CN113462518A (zh) * 2021-07-06 2021-10-01 中国人民解放军军事科学院军事医学研究院 一种用于提取微量新鲜外周血有核细胞蛋白的方法及其专用装置
US20230023772A1 (en) * 2021-07-15 2023-01-26 Techcyte, Inc. Image analysis for qualitative and quantitative analysis of agglutination samples
US11781999B2 (en) 2021-09-05 2023-10-10 Bruker Technologies Ltd. Spot-size control in reflection-based and scatterometry-based X-ray metrology systems
WO2023042143A1 (en) * 2021-09-16 2023-03-23 Thermo Fisher Scientific S.P.A. Process for analyzing of a liquid sample with bubble detection
CN118043679A (zh) * 2021-09-28 2024-05-14 株式会社岛津制作所 扫描探针显微镜、信息处理方法以及程序
CN216274121U (zh) * 2021-10-12 2022-04-12 江苏汇先医药技术有限公司 一种手持式lamp检测仪及系统
CN114279991B (zh) * 2021-12-30 2023-05-12 宜宾五粮液股份有限公司 白酒品牌鉴定的方法
WO2023176400A1 (ja) 2022-03-17 2023-09-21 富士フイルム株式会社 検査装置
USD1014780S1 (en) 2022-04-15 2024-02-13 Instrumentation Laboratory Co. Cuvette
CN114894830B (zh) * 2022-04-27 2024-05-17 中国地质大学（武汉） 利用esr分段逐级扫描检测废水中重金属离子的方法
WO2023210384A1 (ja) * 2022-04-28 2023-11-02 富士フイルム株式会社 検査装置
EP4290216A1 (en) * 2022-06-09 2023-12-13 Usense Multi-analysis device and method
CN115317415B (zh) * 2022-07-07 2023-07-07 广州巴宝莉化妆品有限公司 一种植物鲜花提取物的复合物制备方法
US11913967B2 (en) 2022-07-22 2024-02-27 Spaero Inc. System and method for determining dispensing volume for a liquid handler
EP4438178A1 (de) * 2023-03-31 2024-10-02 MVZ Medizinische Labore Dessau Kassel GmbH Behälter zur aufnahme einer kapillarblutprobe und kit zur gewinnung einer kapillarblutprobe
CN117232909B (zh) * 2023-11-15 2024-01-12 德州市红拳医疗器械有限公司 一种尿检取样装置

Family Cites Families (820)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2398234A (en) 1942-12-11 1946-04-09 Horton & Converse Adjustable automatic pipette
US3640434A (en) 1970-05-15 1972-02-08 Sherwood Medical Ind Inc Variable capacity fluid-dispensing device
US3696971A (en) 1970-09-24 1972-10-10 Electro Nucleonics Mechanism for simultaneously metering and dispensing liquids
US3756920A (en) 1971-04-30 1973-09-04 Nasa In biological samples my measuring light reactions automatic instrument for chemical processing to dedect microorganisms
GB1332207A (en) 1971-05-07 1973-10-03 Ass Elect Ind Apparatus for charged particle spectroscopy
BE793544A (fr) * 1972-01-31 1973-04-16 American Hospital Supply Corp Centrifugeur
CA972183A (en) 1973-02-23 1975-08-05 Georges Revillet Microspectrophotometer
US3953172A (en) * 1974-05-10 1976-04-27 Union Carbide Corporation Method and apparatus for assaying liquid materials
NL179870C (nl) 1974-08-16 1986-12-01 Sarstedt Kunststoff Vat voor het afnemen van bloed met een capillair mondstuk.
US4010893A (en) 1975-06-20 1977-03-08 Becton, Dickinson And Company Triac centrifuge
GB1562900A (en) * 1975-09-24 1980-03-19 Aes Scient Ltd Preparation of blood plasma and serum samples
US4157781A (en) 1978-07-19 1979-06-12 Hitoshi Maruyama Self balancing centrifuge
US4276383A (en) 1979-08-02 1981-06-30 The United States Of America As Represented By The Department Of Health, Education & Welfare Clot lysing timer
US4270921A (en) 1979-09-24 1981-06-02 Graas Joseph E Microchromatographic device and method for rapid determination of a desired substance
US4250830A (en) 1979-10-03 1981-02-17 Leif Robert C Swinging buckets
US4276258A (en) 1980-01-28 1981-06-30 Coulter Electronics, Inc. Sample and stat feeding system and sample tray
US4362698A (en) 1980-03-07 1982-12-07 Sherman-Boosalis Corporation Closures for fluid sample cups
US4327595A (en) 1980-07-07 1982-05-04 Hamilton Company Method and apparatus for simultaneous dilution and dispensation
US4344563A (en) * 1980-12-23 1982-08-17 E. I. Du Pont De Nemours And Company Centrifuge rotor having vertically offset trunnion pins
FR2498331A1 (fr) 1981-01-20 1982-07-23 Kadouche Jean Recipient reactif pour analyse notamment immunologique
US4488814A (en) 1981-09-28 1984-12-18 Miles Laboratories, Inc. Apparatus for and method of optical absorbance and fluorescent radiation measurement
US4486315A (en) * 1982-03-11 1984-12-04 Ortho Diagnostic Systems Inc. Immunoassay microparticle washing system and method of use
US4437586A (en) 1982-03-29 1984-03-20 Eastman Kodak Company Mechanically actuated pipette dispenser
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4554839A (en) 1983-10-14 1985-11-26 Cetus Corporation Multiple trough vessel for automated liquid handling apparatus
US5171534A (en) 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US4545497A (en) 1984-11-16 1985-10-08 Millipore Corporation Container cap with frangible septum
JPS61202142A (ja) * 1985-03-06 1986-09-06 Teijin Ltd 吸光度を用いた分析方法および分析装置
JPS61202141A (ja) 1985-03-06 1986-09-06 Nec Corp 吸光光度計
US4593837A (en) 1985-03-15 1986-06-10 Eastman Kodak Company Variable volume pipette
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
JPS61254833A (ja) * 1985-05-08 1986-11-12 Toyo Soda Mfg Co Ltd 液定量取出し装置
US4756884A (en) 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
DE3614085A1 (de) 1985-12-12 1987-06-19 Hirschmann Glasgeraete Pipette
CH671526A5 (ru) 1985-12-17 1989-09-15 Hamilton Bonaduz Ag
JPH0652227B2 (ja) 1986-04-25 1994-07-06 梅谷 陽二 微小注入量測定装置
GB2190195A (en) 1986-05-09 1987-11-11 Cambridge Life Sciences Microtitre plate reader
JPH0727700Y2 (ja) 1986-06-16 1995-06-21 日本電気株式会社 Ｐｌｌシンセサイザの制御回路
US4744955A (en) 1986-08-08 1988-05-17 Shapiro Justin J Adjustable volume pipette sampler
US5322770A (en) 1989-12-22 1994-06-21 Hoffman-Laroche Inc. Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription
US5310652A (en) 1986-08-22 1994-05-10 Hoffman-La Roche Inc. Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription
JPH0816675B2 (ja) 1986-09-26 1996-02-21 株式会社島津製作所 ガスクロマトグラフ装置
US4933291A (en) 1986-12-22 1990-06-12 Eastman Kodak Company Centrifugable pipette tip and pipette therefor
JPH0697231B2 (ja) 1987-07-15 1994-11-30 富士写真フイルム株式会社 生化学分析装置
US4822331A (en) 1987-11-09 1989-04-18 Taylor David C Centrifuge
US5055263A (en) 1988-01-14 1991-10-08 Cyberlab, Inc. Automated pipetting system
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US4925629A (en) 1988-07-28 1990-05-15 Bioquant, Inc. Diagnostic device
US5320808A (en) 1988-08-02 1994-06-14 Abbott Laboratories Reaction cartridge and carousel for biological sample analyzer
JPH0275959A (ja) 1988-09-12 1990-03-15 Nittec Co Ltd 自動分折装置
US5186162A (en) 1988-09-14 1993-02-16 Interpore Orthopaedics, Inc. Ultrasonic transducer device for treatment of living tissue and/or cells
US4927545A (en) 1988-10-06 1990-05-22 Medical Automation Specialties, Inc. Method and apparatus for automatic processing and analyzing of blood serum
US4962041A (en) 1988-10-06 1990-10-09 Medical Automation Specialities, Inc. Method and apparatus for automatic processing and analyzing of blood serum
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
AU5645690A (en) 1989-05-05 1990-11-29 Lifecodes Corporation Method for genetic analysis of a nucleic acid sample
US5480784A (en) 1989-07-11 1996-01-02 Gen-Probe Incorporated Nucleic acid sequence amplification methods
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5683888A (en) 1989-07-22 1997-11-04 University Of Wales College Of Medicine Modified bioluminescent proteins and their use
IL94212A0 (en) 1989-07-24 1991-01-31 Tri Tech Partners And Triton B Automated analytical apparatus and method
US5061449A (en) 1989-07-25 1991-10-29 Matrix Technologies, Corp. Expandable multi-channel pipetter
US5005981A (en) 1989-09-08 1991-04-09 Becton, Dickinson And Company Apparatus for method for causing vortices in a test tube
US5072382A (en) 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5089229A (en) 1989-11-22 1992-02-18 Vettest S.A. Chemical analyzer
JP2731613B2 (ja) 1989-12-12 1998-03-25 株式会社クラレ 酵素免疫測定用カートリツジ、それを用いた測定方法及び測定装置
US5859205A (en) 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
US5292658A (en) 1989-12-29 1994-03-08 University Of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center Cloning and expressions of Renilla luciferase
US5173193A (en) 1991-04-01 1992-12-22 Schembri Carol T Centrifugal rotor having flow partition
US5242606A (en) 1990-06-04 1993-09-07 Abaxis, Incorporated Sample metering port for analytical rotor having overflow chamber
US5061381A (en) 1990-06-04 1991-10-29 Abaxis, Inc. Apparatus and method for separating cells from biological fluids
US5122284A (en) 1990-06-04 1992-06-16 Abaxis, Inc. Apparatus and method for optically analyzing biological fluids
DK0533838T3 (da) 1990-06-11 1998-02-23 Nexstar Pharmaceuticals Inc Nukleinsyreligander
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
US5527670A (en) 1990-09-12 1996-06-18 Scientific Generics Limited Electrochemical denaturation of double-stranded nucleic acid
DE69125441T2 (de) 1990-09-28 1997-11-06 Toshiba Kawasaki Kk Verfahren zum Gennachweis
JP2969935B2 (ja) * 1990-11-30 1999-11-02 東ソー株式会社 液定量取出し装置
DE4041905A1 (de) 1990-12-27 1992-07-02 Boehringer Mannheim Gmbh Testtraeger-analysesystem
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
FR2673183B1 (fr) 1991-02-21 1996-09-27 Asulab Sa Complexes mono, bis ou tris (2,2'-bipyridine substituee) d'un metal choisi parmi le fer, le ruthenium, l'osmium ou le vanadium et leurs procedes de preparation .
US5273905A (en) 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
ES2142801T3 (es) 1991-03-11 2000-05-01 Univ Georgia Res Found Clonacion y expresion de luciferasa de renilla.
US5264184A (en) 1991-03-19 1993-11-23 Minnesota Mining And Manufacturing Company Device and a method for separating liquid samples
US5230864A (en) 1991-04-10 1993-07-27 Eastman Kodak Company Gravity assisted collection device
US5112574A (en) 1991-04-26 1992-05-12 Imanigation, Ltd. Multititer stopper array for multititer plate or tray
US5324481A (en) 1991-06-03 1994-06-28 Abbott Laboratories Carousel for assay specimen carrier
US6407213B1 (en) 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
FR2679661B1 (fr) 1991-07-26 1994-10-14 Sfri Appareil d'analyse automatique d'echantillons.
EP0541340B1 (en) 1991-11-05 1997-07-16 The Perkin-Elmer Corporation Biopolymer synthesis apparatus and method
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
US5960160A (en) 1992-03-27 1999-09-28 Abbott Laboratories Liquid heater assembly with a pair temperature controlled electric heating elements and a coiled tube therebetween
US5507410A (en) 1992-03-27 1996-04-16 Abbott Laboratories Meia cartridge feeder
US5288390A (en) 1992-03-30 1994-02-22 Sun Company, Inc. (R&M) Polycyclic aromatic ring cleavage (PARC) process
AU4047493A (en) 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
EP0639223B1 (en) 1992-05-01 1996-07-03 The Trustees Of The University Of Pennsylvania Microfabricated sperm handling devices
US5380487A (en) 1992-05-05 1995-01-10 Pasteur Sanofi Diagnostics Device for automatic chemical analysis
US5357953A (en) 1992-05-21 1994-10-25 Puritan-Bennett Corporation Measurement device and method of calibration
WO1994007142A1 (en) 1992-09-14 1994-03-31 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
EP0619476B1 (de) * 1992-12-19 1999-09-22 Boehringer Mannheim Gmbh Vorrichtung zur Detektion einer Flüssigkeitphasengrenze in einem lichtdurchlässigen Messrohr
DE4305581A1 (de) * 1993-02-24 1994-08-25 Hettich Andreas Fa Rotor für eine Schwenkbecherzentrifuge
US5416879A (en) 1993-03-29 1995-05-16 World Precision Instruments, Inc. Apparatus and method for measuring light absorption in small aqueous fluid samples
US5478750A (en) 1993-03-31 1995-12-26 Abaxis, Inc. Methods for photometric analysis
JP3563140B2 (ja) 1995-01-19 2004-09-08 株式会社日立製作所 キャピラリーアレイ電気泳動装置
KR960703174A (ko) 1993-06-09 1996-06-19 미안 알렉 자기장 순환식 반응방법(magnetic cycle reaction)
US5578269A (en) 1993-06-11 1996-11-26 Ortho Diagnostic Systems Inc. Automated blood analysis system with an integral centrifuge
DE69430152T2 (de) 1993-06-25 2002-10-31 Edward W. Stark Verfahren und Vorrichtung zum Messen von Glukoseverwandten Substanzen
JP3343156B2 (ja) * 1993-07-14 2002-11-11 アークレイ株式会社 光学式成分濃度測定装置および方法
GB9315671D0 (en) 1993-07-29 1993-09-15 Dow Corning Sa Foam control agents and their use
ITMI931761A1 (it) 1993-08-03 1995-02-03 Healtech Sa Dispositivo di supporto di informazioni associabile a pazienti ambulatoriali o ospedalieri per la loro identificazione automatica ed
ES2179847T3 (es) 1993-08-13 2003-02-01 Albany Molecular Res Inc Metodos biocataliticos para la sintesis e identificacion de compuestos biologicamente activos.
TW265262B (en) * 1993-08-13 1995-12-11 Nat Science Committee Mother-and-child interconnected centrifuge tube used for solution separation
CA2129787A1 (en) 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
US5397709A (en) 1993-08-27 1995-03-14 Becton Dickinson And Company System for detecting bacterial growth in a plurality of culture vials
US6235531B1 (en) 1993-09-01 2001-05-22 Abaxis, Inc. Modified siphons for improved metering precision
US5591643A (en) 1993-09-01 1997-01-07 Abaxis, Inc. Simplified inlet channels
JPH0783936A (ja) 1993-09-10 1995-03-31 Taitetsuku Kk 理化学実験方法
DE69435112D1 (de) 1993-09-10 2008-08-21 Univ Columbia Verwendung von grünem fluoreszenzprotein
EP0720747B1 (en) 1993-09-24 2002-07-17 Abbott Laboratories Automated continuous and random access analytical system and components thereof
JP3391862B2 (ja) 1993-10-05 2003-03-31 株式会社日立製作所 クロマトグラム解析方法
JPH07120393A (ja) 1993-10-13 1995-05-12 Nippon Tectron Co Ltd 蛍光検出法
US5525300A (en) 1993-10-20 1996-06-11 Stratagene Thermal cycler including a temperature gradient block
DE69433727T2 (de) 1993-11-02 2004-09-30 Matsushita Electric Industrial Co., Ltd., Kadoma Halbleiterbauelement mit einem Aggregat von Mikro-Nadeln aus Halbleitermaterial
US5403415A (en) 1993-11-17 1995-04-04 Abaxis, Inc. Method and device for ultrasonic welding
US6252980B1 (en) * 1993-11-24 2001-06-26 Nira Schwartz Additional dynamic fluid level and bubble inspection for quality and process control
JPH07151101A (ja) 1993-11-29 1995-06-13 Kazuo Sugimura ダイヤフラム接触面が渦巻状の容器
JPH07196314A (ja) 1993-12-28 1995-08-01 Maruo Calcium Co Ltd チューブ状合成無機微粒子
WO1995021191A1 (en) 1994-02-04 1995-08-10 William Ward Bioluminescent indicator based upon the expression of a gene for a modified green-fluorescent protein
US6033850A (en) 1994-03-15 2000-03-07 Affymetrix, Inc. Electrochemical denaturation of double-stranded nucleic acid
US5590052A (en) 1994-04-14 1996-12-31 Abaxis, Inc. Error checking in blood analyzer
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
CA2147560A1 (en) 1994-04-22 1995-10-23 Donald H. Devaughn Aerosol and liquid transfer resistant pipette tip apparatus and method
US5483799A (en) 1994-04-29 1996-01-16 Dalto; Michael Temperature regulated specimen transporter
JP3584990B2 (ja) 1994-05-09 2004-11-04 タカラバイオ株式会社 抗ヒトインフルエンザウイルス抗体
US5976896A (en) 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
JP2637695B2 (ja) 1994-07-12 1997-08-06 株式会社バイオセンサー研究所 溶液吸引器具および吸引式溶液内微量物質測定装置
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
EP0771417B8 (en) 1994-07-25 2009-10-28 MDS Analytical Technologies (US) Inc. Determination of light absorption pathlength in a vertical-beam photometer
US5891734A (en) 1994-08-01 1999-04-06 Abbott Laboratories Method for performing automated analysis
US5527257A (en) 1994-09-14 1996-06-18 Piramoon Technologies, Inc. Rotor having endless straps for mounting swinging buckets
JP3652424B2 (ja) 1994-10-27 2005-05-25 日本政策投資銀行 自動分析装置及びその方法
JP3403839B2 (ja) 1994-10-27 2003-05-06 プレシジョン・システム・サイエンス株式会社 カートリッジ容器
US5777079A (en) 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US6484897B1 (en) 1995-02-13 2002-11-26 Amcad Holdings Limited Containers with variable volume
US5557596A (en) 1995-03-20 1996-09-17 Gibson; Gary Ultra-high density storage device
US5578270A (en) 1995-03-24 1996-11-26 Becton Dickinson And Company System for nucleic acid based diagnostic assay
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6340588B1 (en) 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US5582705A (en) 1995-05-19 1996-12-10 Iowa State University Research Foundation, Inc. Multiplexed capillary electrophoresis system
US5772962A (en) 1995-05-29 1998-06-30 Hitachi, Ltd. Analyzing apparatus using disposable reaction vessels
US5518923A (en) 1995-06-06 1996-05-21 Becton Dickinson And Company Compact blood culture apparatus
JP3839524B2 (ja) 1995-06-07 2006-11-01 アジレント・テクノロジーズ・インク 小型化全分析システム
US6274288B1 (en) * 1995-06-12 2001-08-14 California Institute Of Technology Self-trapping and self-focusing of optical beams in photopolymers
US6168948B1 (en) 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
CA2226776C (en) 1995-07-31 2007-11-27 Hideji Tajima Multi-vessel container for testing fluids
JP3927570B2 (ja) 1995-07-31 2007-06-13 プレシジョン・システム・サイエンス株式会社 容器
JPH0968533A (ja) 1995-08-31 1997-03-11 Brother Ind Ltd 薬品投与量を表示可能な生化学物質測定装置
JP3515646B2 (ja) 1995-09-18 2004-04-05 大塚電子株式会社 マルチキャピラリ電気泳動装置
DE19535046C2 (de) 1995-09-21 1998-04-16 Eppendorf Geraetebau Netheler Handgerät zum Pipettieren und photometrischen Messen von Proben
US5628890A (en) 1995-09-27 1997-05-13 Medisense, Inc. Electrochemical sensor
JPH09113511A (ja) 1995-10-18 1997-05-02 Kdk Corp グリコアルブミン測定用乾式試験片
US5687716A (en) 1995-11-15 1997-11-18 Kaufmann; Peter Selective differentiating diagnostic process based on broad data bases
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
US20060074063A1 (en) 1995-12-29 2006-04-06 Fernandez-Pol Jose A Pharmacological agent and method of treatment
JPH09192218A (ja) 1996-01-16 1997-07-29 Hitachi Ltd 血糖値管理システム
US5874304A (en) 1996-01-18 1999-02-23 University Of Florida Research Foundation, Inc. Humanized green fluorescent protein genes and methods
US5863502A (en) 1996-01-24 1999-01-26 Sarnoff Corporation Parallel reaction cassette and associated devices
CN1096185C (zh) 1996-01-27 2002-12-11 三星电子株式会社 使用运动和空间相关的隔行向逐行转换装置和方法
US5804387A (en) 1996-02-01 1998-09-08 The Board Of Trustees Of The Leland Stanford Junior University FACS-optimized mutants of the green fluorescent protein (GFP)
US5876995A (en) 1996-02-06 1999-03-02 Bryan; Bruce Bioluminescent novelty items
US5670375A (en) 1996-02-21 1997-09-23 Biomerieux Vitek, Inc. Sample card transport method for biological sample testing machine
JP2988362B2 (ja) 1996-03-11 1999-12-13 株式会社日立製作所 多検体分析システム
JPH09244055A (ja) 1996-03-14 1997-09-19 Hitachi Ltd 液晶表示装置
DE19610538A1 (de) 1996-03-18 1997-09-25 Deutsches Krebsforsch Strahlungsermittlungsvorrichtung
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
JP2783277B2 (ja) 1996-03-27 1998-08-06 日本電気株式会社 患者監視装置及び患者監視システム
EP0801309A3 (en) 1996-04-08 1998-08-12 SANYO ELECTRIC Co., Ltd. Pipetting apparatus
JPH09281078A (ja) 1996-04-09 1997-10-31 Hitachi Electron Eng Co Ltd Ｄｎａ塩基配列決定装置
US5896297A (en) 1996-04-15 1999-04-20 Valerino, Sr.; Fred M. Robotube delivery system
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US6399023B1 (en) 1996-04-16 2002-06-04 Caliper Technologies Corp. Analytical system and method
US5885470A (en) 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
JP3213566B2 (ja) 1996-04-26 2001-10-02 アークレイ株式会社 検体分析用具およびそれを用いた検体分析方法並びに検体分析装置
US5851170A (en) * 1996-04-30 1998-12-22 Dade Behring Inc. Centrifuge with cam selectable rotational angles and method for unloading same
EP0837311B1 (en) * 1996-05-02 2004-07-21 Sankyo Manufacturing Company, Ltd. Noncontact inspection apparatus
US5879628A (en) 1996-05-06 1999-03-09 Helena Laboratories Corporation Blood coagulation system having a bar code reader and a detecting means for detecting the presence of reagents in the cuvette
US5980830A (en) 1996-05-20 1999-11-09 Sendx Medical, Inc. Portable modular blood analyzer with simplified fluid handling sequence
JP3682302B2 (ja) 1996-05-20 2005-08-10 プレシジョン・システム・サイエンス株式会社 分注機による磁性体粒子の制御方法およびその装置
IL118432A (en) 1996-05-27 1999-12-31 Yissum Res Dev Co Electrochemical and photochemical electrodes and their use
WO1997046707A2 (en) 1996-06-04 1997-12-11 University Of Utah Research Foundation System and method for monitoring for dna amplification by fluorescence
US5939291A (en) 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
WO1998000231A1 (en) 1996-06-28 1998-01-08 Caliper Technologies Corporation High-throughput screening assay systems in microscale fluidic devices
US5797898A (en) 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US5807523A (en) 1996-07-03 1998-09-15 Beckman Instruments, Inc. Automatic chemistry analyzer
CA2255839A1 (en) 1996-07-05 1998-01-15 Mark Gross Automated sample processing system
EP0818547A1 (en) 1996-07-10 1998-01-14 Autoliv ASP, Inc. Recovery of metals values from air bag inflators
US5925558A (en) 1996-07-16 1999-07-20 The Regents Of The University Of California Assays for protein kinases using fluorescent protein substrates
US6145688A (en) 1996-07-17 2000-11-14 Smith; James C. Closure device for containers
US5915284A (en) 1996-07-22 1999-06-22 Cyberlab, Inc. Multiple channel pipetting device
US6101488A (en) 1996-09-04 2000-08-08 Fujitsu Limited Intelligent information program generation and retrieval system
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
JP3270722B2 (ja) * 1996-09-27 2002-04-02 オルガノ株式会社 細菌の検出方法及び検出装置
GB9620209D0 (en) 1996-09-27 1996-11-13 Cemu Bioteknik Ab Method of sequencing DNA
US5976796A (en) 1996-10-04 1999-11-02 Loma Linda University Construction and expression of renilla luciferase and green fluorescent protein fusion genes
US5874046A (en) 1996-10-30 1999-02-23 Raytheon Company Biological warfare agent sensor system employing ruthenium-terminated oligonucleotides complementary to target live agent DNA sequences
GB9624096D0 (en) 1996-11-20 1997-01-08 Microbial Systems Ltd Apparatus and method of use thereof
US6379929B1 (en) 1996-11-20 2002-04-30 The Regents Of The University Of Michigan Chip-based isothermal amplification devices and methods
US6071251A (en) 1996-12-06 2000-06-06 Abbott Laboratories Method and apparatus for obtaining blood for diagnostic tests
WO1998026277A2 (en) 1996-12-12 1998-06-18 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
KR100233283B1 (ko) 1996-12-24 1999-12-01 김영환 플래쉬 메모리 셀을 이용한 리페어 퓨즈 초기화 회로
JPH10239240A (ja) 1997-02-25 1998-09-11 Hitachi Ltd 自動ｄｎａプローブ装置
IL131619A (en) 1997-02-28 2002-12-01 Burstein Technologies Inc Laboratory on disk
DK2333520T3 (da) 1997-02-28 2014-09-29 Cepheid Varmevekslende, forespurgt indretning til kemisk reaktion
US6013528A (en) * 1997-03-11 2000-01-11 Ortho-Clinical Diagnostis, Inc. Analyzer throughput featuring through-the-tip analysis
US5846492A (en) * 1997-03-11 1998-12-08 Johnson & Johnson Clinical Diagnostics, Inc. Sample quality measurement and/or analyte measurement in the dispensing tip of an analyzer
JP3393361B2 (ja) 1997-03-24 2003-04-07 国立身体障害者リハビリテーションセンター総長 バイオセンサ
GB9706654D0 (en) 1997-04-02 1997-05-21 Scient Generics Ltd Disassociation of interacting molecules
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
WO1998045474A1 (en) 1997-04-04 1998-10-15 Innogenetics N.V. Isothermal polymerase chain reaction by cycling the concentration of divalent metal ions
US5961451A (en) 1997-04-07 1999-10-05 Motorola, Inc. Noninvasive apparatus having a retaining member to retain a removable biosensor
DE69837230T2 (de) 1997-04-10 2007-12-20 Hitachi, Ltd. Automatische Analysevorrichtung
DE19717023C2 (de) 1997-04-23 2003-02-06 Micronas Gmbh Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen
KR100351531B1 (ko) 1997-04-25 2002-09-11 캘리퍼 테크놀로지스 코포레이션 기하형상이 개선된 채널을 채용하는 미소 유체 장치
US6429007B1 (en) 1997-05-02 2002-08-06 BIOMéRIEUX, INC. Nucleic acid amplification reaction station for disposable test devices
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
JPH10305016A (ja) 1997-05-08 1998-11-17 Casio Comput Co Ltd 行動情報提供システム
US5985214A (en) 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
ATE306324T1 (de) 1997-06-09 2005-10-15 Hoffmann La Roche Einweg-analysevorrichtung
US6115545A (en) 1997-07-09 2000-09-05 Hewlett-Packard Company Automatic internet protocol (IP) address allocation and assignment
JP2002511965A (ja) 1997-07-14 2002-04-16 アボツト・ラボラトリーズ 遠隔医療
US6589789B1 (en) 1997-07-21 2003-07-08 Quest Diagnostics Incorporated Automated centrifuge loading device
JPH1137845A (ja) 1997-07-22 1999-02-12 Matsushita Electric Ind Co Ltd 血清量測定装置
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US6294331B1 (en) 1997-08-08 2001-09-25 The United States Of America As Represented By The Department Of Health And Human Services Methods for assessing genetic and phenotypic markers by simultaneous multicolor visualization of chromogenic dyes using brightfield microscopy and spectral imaging
US6368871B1 (en) 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
WO1999033559A1 (en) 1997-12-24 1999-07-08 Cepheid Integrated fluid manipulation cartridge
JPH1157560A (ja) 1997-08-27 1999-03-02 Shin Meiwa Ind Co Ltd 液体散布車
US6042909A (en) 1997-09-03 2000-03-28 Circe Biomedical, Inc. Encapsulation device
DK0902290T3 (da) 1997-09-11 2009-02-09 Hitachi Ltd Et prövehåndteringssystem til automatiske analyseindretninger
US6597450B1 (en) 1997-09-15 2003-07-22 Becton, Dickinson And Company Automated Optical Reader for Nucleic Acid Assays
US6902703B2 (en) 1999-05-03 2005-06-07 Ljl Biosystems, Inc. Integrated sample-processing system
US6982431B2 (en) * 1998-08-31 2006-01-03 Molecular Devices Corporation Sample analysis systems
US6825921B1 (en) 1999-11-10 2004-11-30 Molecular Devices Corporation Multi-mode light detection system
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
DE19745373A1 (de) 1997-10-14 1999-04-15 Bayer Ag Optisches Meßsystem zur Erfassung von Lumineszenz- oder Fluoreszenzsignalen
US6121054A (en) 1997-11-19 2000-09-19 Trega Biosciences, Inc. Method for separation of liquid and solid phases for solid phase organic syntheses
US6174675B1 (en) 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
AUPP058197A0 (en) 1997-11-27 1997-12-18 A.I. Scientific Pty Ltd Pathology sample tube distributor
US6083682A (en) 1997-12-19 2000-07-04 Glaxo Group Limited System and method for solid-phase parallel synthesis of a combinatorial collection of compounds
US6074616A (en) 1998-01-05 2000-06-13 Biosite Diagnostics, Inc. Media carrier for an assay device
US5993417A (en) 1998-01-06 1999-11-30 Yerfino; Daniel Alberto Disposable syringe with an automatically retractable hypodermic needle
EP1060022A1 (en) 1998-02-04 2000-12-20 Merck & Co., Inc. Virtual wells for use in high throughput screening assays
US6420143B1 (en) 1998-02-13 2002-07-16 Caliper Technologies Corp. Methods and systems for performing superheated reactions in microscale fluidic systems
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US6752965B2 (en) 1998-03-06 2004-06-22 Abner Levy Self resealing elastomeric closure
US20110130740A1 (en) 1998-03-06 2011-06-02 Abner Levy Medication Bottle for Use with Oral Syringe
US6030582A (en) 1998-03-06 2000-02-29 Levy; Abner Self-resealing, puncturable container cap
US6127184A (en) * 1998-03-07 2000-10-03 Robert A. Levine Calibration of a whole blood sample analyzer
US6235536B1 (en) * 1998-03-07 2001-05-22 Robert A. Levine Analysis of quiescent anticoagulated whole blood samples
US6929953B1 (en) * 1998-03-07 2005-08-16 Robert A. Levine Apparatus for analyzing biologic fluids
US6979424B2 (en) 1998-03-17 2005-12-27 Cepheid Integrated sample analysis device
US7188001B2 (en) 1998-03-23 2007-03-06 Cepheid System and method for temperature control
CA2324648C (en) 1998-03-27 2013-02-26 Prolume, Ltd. Luciferases, fluorescent proteins, nucleic acids encoding the luciferases and fluorescent proteins and the use thereof in diagnostics, high throughput screening and novelty items
US6235534B1 (en) * 1998-04-27 2001-05-22 Ronald Frederich Brookes Incremental absorbance scanning of liquid in dispensing tips
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
DK1075328T3 (da) 1998-05-01 2006-03-27 Gen Probe Inc Automatiseret diagnostisk analysefremgangsmåde
EP0955097B1 (en) 1998-05-04 2004-10-06 F. Hoffmann-La Roche Ag Thermal cycler having an automatically positionable cover
US6200531B1 (en) 1998-05-11 2001-03-13 Igen International, Inc. Apparatus for carrying out electrochemiluminescence test measurements
US7394363B1 (en) 1998-05-12 2008-07-01 Bahador Ghahramani Intelligent multi purpose early warning system for shipping containers, components therefor and methods of making the same
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
US6287765B1 (en) 1998-05-20 2001-09-11 Molecular Machines, Inc. Methods for detecting and identifying single molecules
EP0962773A1 (en) 1998-06-03 1999-12-08 Mark Howard Jones Electrochemical based assay processes instrument and labels
JP3389106B2 (ja) 1998-06-11 2003-03-24 松下電器産業株式会社 電気化学分析素子
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
WO2000001531A1 (en) 1998-07-06 2000-01-13 The Coca-Cola Company Basket with integrally-formed receptacle
GB9816088D0 (en) 1998-07-23 1998-09-23 Axis Biochemicals Asa System
US6091490A (en) 1998-07-30 2000-07-18 The United States Of America As Represented By The Secretary Of The Navy Fiber-optic pipette (FOP) for rapid long pathlength capillary spectroscopy
DE19835833A1 (de) 1998-08-07 2000-02-17 Max Planck Gesellschaft Dosierkopf zur parallelen Bearbeitung einer Vielzahl von Fluidproben
US6562300B2 (en) 1998-08-28 2003-05-13 Becton, Dickinson And Company Collection assembly
US6517475B1 (en) 1998-09-25 2003-02-11 Baldwin Filters, Inc. Centrifugal filter for removing soot from engine oil
US6159368A (en) 1998-10-29 2000-12-12 The Perkin-Elmer Corporation Multi-well microfiltration apparatus
ATE521718T1 (de) 1998-11-09 2011-09-15 Eiken Chemical Prozess zur synthetisierung von nukleinsäure
US20100262432A1 (en) 1998-11-13 2010-10-14 Anuthep Benja-Athon Computer-created-consensus-based health-care system
US20030012699A1 (en) 1998-11-18 2003-01-16 Thomas Moore Simultaneous handling of magnetic beads in a two-dimensional arrangement
US6309828B1 (en) 1998-11-18 2001-10-30 Agilent Technologies, Inc. Method and apparatus for fabricating replicate arrays of nucleic acid molecules
RU2147123C1 (ru) 1998-12-16 2000-03-27 Боев Сергей Федотович Способ анализа клеточного состава крови по мазку
US7914994B2 (en) 1998-12-24 2011-03-29 Cepheid Method for separating an analyte from a sample
CA2702148C (en) 1999-01-06 2014-03-04 Genenews Inc. Method of profiling gene expression in a human subject having an infectious disease
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
US8885913B2 (en) * 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
JP3330929B2 (ja) 1999-01-25 2002-10-07 浜松ホトニクス株式会社 ピペットアダプタ、吸光度測定用ピペット、チップ、吸光度測定装置及び吸光度測定方法
US6348176B1 (en) 1999-02-11 2002-02-19 Careside, Inc. Cartridge-based analytical instrument using centrifugal force/pressure for metering/transport of fluids
GB9903906D0 (en) 1999-02-19 1999-04-14 Microbiological Res Authority Method and apparatus for nucleic acid strand separation
US6215894B1 (en) 1999-02-26 2001-04-10 General Scanning, Incorporated Automatic imaging and analysis of microarray biochips
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6291249B1 (en) 1999-03-02 2001-09-18 Qualigen, Inc. Method using an apparatus for separation of biological fluids
EP1129772A3 (en) 1999-03-03 2001-11-07 Symyx Technologies, Inc. Fluid distribution for chemical processing microsystems
JP3524419B2 (ja) * 1999-03-08 2004-05-10 アロカ株式会社 吸光度測定装置
US20020176801A1 (en) 1999-03-23 2002-11-28 Giebeler Robert H. Fluid delivery and analysis systems
US6305804B1 (en) 1999-03-25 2001-10-23 Fovioptics, Inc. Non-invasive measurement of blood component using retinal imaging
US6699669B2 (en) 1999-04-09 2004-03-02 Space Hardware Optimization Technology, Inc. Multistage electromagnetic separator for purifying cells, chemicals and protein structures
US6143252A (en) 1999-04-12 2000-11-07 The Perkin-Elmer Corporation Pipetting device with pipette tip for solid phase reactions
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
US20040053290A1 (en) 2000-01-11 2004-03-18 Terbrueggen Robert Henry Devices and methods for biochip multiplexing
JP4085514B2 (ja) 1999-04-30 2008-05-14 株式会社島津製作所 電気泳動チップ
AU4838600A (en) 1999-05-11 2000-11-21 Ortho-Mcneil Pharmaceutical, Inc. Enhanced survival of cancer patients treated with erythropoietin and antitumor agents
US6582964B1 (en) 1999-05-12 2003-06-24 Cme Telemetrix Inc. Method and apparatus for rapid measurement of HbA1c
US6716396B1 (en) 1999-05-14 2004-04-06 Gen-Probe Incorporated Penetrable cap
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
AU782343B2 (en) 1999-05-28 2005-07-21 Cepheid Apparatus and method for analyzing a fluid sample
US7068361B2 (en) 1999-06-03 2006-06-27 Baxter International Apparatus, systems and methods for processing and treating a biological fluid with light
US6056661A (en) 1999-06-14 2000-05-02 General Motors Corporation Multi-range transmission with input split planetary gear set and continuously variable transmission unit
EP1187677B1 (en) 1999-06-22 2003-11-26 Agilent Technologies, Inc. (a Delaware corporation) Apparatus for the operation of a microfluidic device
WO2000078464A1 (fr) * 1999-06-23 2000-12-28 Hitachi, Ltd. Separateur centrifuge et dispositif de preparation d'echantillons mettant en oeuvre ce separateur
US6664104B2 (en) 1999-06-25 2003-12-16 Cepheid Device incorporating a microfluidic chip for separating analyte from a sample
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7951612B2 (en) 1999-07-08 2011-05-31 Lee H. Angros In situ heat induced antigen recovery and staining apparatus and method
US6244119B1 (en) 1999-08-03 2001-06-12 Wallac Oy Multichannel pipette system and pipette tips therefor
KR100675698B1 (ko) 1999-08-06 2007-02-01 써모 바이오스타, 인크. 완전한 샘플 처리 능력을 포함하는 자동화된 진료 검출 시스템
EP1203959B1 (en) 1999-08-11 2007-06-13 Asahi Kasei Kabushiki Kaisha Analyzing cartridge and liquid feed control device
JP2001065458A (ja) 1999-08-25 2001-03-16 Matsushita Electric Ind Co Ltd 圧縮機
US6858185B1 (en) 1999-08-25 2005-02-22 Caliper Life Sciences, Inc. Dilutions in high throughput systems with a single vacuum source
AU5976699A (en) 1999-09-09 2001-04-10 Nokia Corporation Determination of data rate, based on power spectral density estimates
US20030175993A1 (en) 1999-09-10 2003-09-18 Anthony Toranto Ketone assay
DE60009323T2 (de) 1999-09-13 2005-02-10 Nugen Technologies, Inc., San Carlos Methoden und zusammensetzungen zur linearen isothermalen amplifikation von polynukleotidsequenzen
DE19944516B4 (de) 1999-09-16 2006-08-17 Brainlab Ag Dreidimensionale Formerfassung mit Kamerabildern
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US6675037B1 (en) 1999-09-29 2004-01-06 Regents Of The University Of Minnesota MRI-guided interventional mammary procedures
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
US6368275B1 (en) 1999-10-07 2002-04-09 Acuson Corporation Method and apparatus for diagnostic medical information gathering, hyperthermia treatment, or directed gene therapy
JP3481578B2 (ja) 1999-10-12 2003-12-22 松下電器産業株式会社 電子放出素子およびそれを利用した電子源、電界放出型画像表示装置、蛍光灯、並びにそれらの製造方法
US6471916B1 (en) 1999-11-09 2002-10-29 Packard Instrument Company Apparatus and method for calibration of a microarray scanning system
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US6750053B1 (en) 1999-11-15 2004-06-15 I-Stat Corporation Apparatus and method for assaying coagulation in fluid samples
WO2001035928A1 (en) 1999-11-17 2001-05-25 Microchips, Inc. Microfabricated devices for the delivery of molecules into a carrier fluid
JP3441058B2 (ja) 1999-12-03 2003-08-25 理化学研究所 キャピラリーゲル電気泳動用マイクロチップおよびその製造方法
JP2001165752A (ja) 1999-12-06 2001-06-22 Hitachi Ltd 血清量測定装置および測定方法
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
JP4497335B2 (ja) 1999-12-22 2010-07-07 ベックマン・コールター・インコーポレーテッド 分析装置
US7747312B2 (en) 2000-01-04 2010-06-29 George Mason Intellectual Properties, Inc. System and method for automatic shape registration and instrument tracking
EP1246699B1 (en) 2000-01-11 2007-01-03 Clinical Micro Sensors, Inc. Cartridge comprising a biochip
EP1261427B1 (en) 2000-03-02 2011-03-02 Microchips, Inc. Microfabricated devices and methods for storage and selective exposure of chemicals
WO2001067079A1 (en) 2000-03-09 2001-09-13 Clinical Analysis Corp. Medical diagnostic system
AU2001243673A1 (en) 2000-03-15 2001-09-24 Emedicalfiles, Inc. Web-hosted healthcare medical information management system
DE10013511A1 (de) 2000-03-20 2001-10-11 Brand Gmbh & Co Kg Mehrkanal-Pipettiereinrichtung sowie Pipettenschaft dafür
US6488827B1 (en) 2000-03-31 2002-12-03 Lifescan, Inc. Capillary flow control in a medical diagnostic device
US6413213B1 (en) 2000-04-18 2002-07-02 Roche Diagnostics Corporation Subscription based monitoring system and method
ES2319864T3 (es) 2000-04-28 2009-05-14 St. Jude Children's Research Hospital Sistema de transfeccion de adn para la generacion de virus infecciosos de arn de cadena negativa.
DE10022693C1 (de) 2000-05-05 2001-10-11 Cybio Instr Gmbh Pipettierautomat mit einem Einreihigen-Mehrkanal-Pipettierkopf
US20020052761A1 (en) 2000-05-11 2002-05-02 Fey Christopher T. Method and system for genetic screening data collection, analysis, report generation and access
US7006858B2 (en) 2000-05-15 2006-02-28 Silver James H Implantable, retrievable sensors and immunosensors
EP1284818B1 (en) 2000-05-15 2006-11-22 Tecan Trading AG Bidirectional flow centrifugal microfluidic devices
US6917726B2 (en) 2001-09-27 2005-07-12 Cornell Research Foundation, Inc. Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes
US6943035B1 (en) 2000-05-19 2005-09-13 Genetix Limited Liquid dispensing apparatus and method
IL163684A0 (en) 2000-05-31 2005-12-18 Given Imaging Ltd Measurement of electrical characteristics of tissue
EP1585423B1 (en) 2000-06-01 2016-08-17 Leidos, Inc. Transdermal microfluidic sampling system
WO2001093743A2 (en) 2000-06-07 2001-12-13 Healthetech, Inc. Breath ketone analyzer
US7276158B1 (en) 2000-06-09 2007-10-02 Ashok K Shukla Incision-based filtration/separation pipette tip
US6465953B1 (en) 2000-06-12 2002-10-15 General Electric Company Plastic substrates with improved barrier properties for devices sensitive to water and/or oxygen, such as organic electroluminescent devices
JP3638503B2 (ja) 2000-06-12 2005-04-13 アークレイ株式会社 カートリッジ式容器を用いる測定装置および測定方法並びに記録媒体
FR2810407B1 (fr) 2000-06-16 2002-08-02 Philippe Escal Appareil pour l'analyse d'echantillons
US6859830B1 (en) 2000-06-23 2005-02-22 Microsoft Corporation Method and system for detecting a dead server
US6468474B2 (en) 2000-07-06 2002-10-22 Varian, Inc. Saliva testing and confirmation device
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
JP2002031055A (ja) 2000-07-14 2002-01-31 Matsushita Electric Ind Co Ltd 密閉型圧縮機
AU2001273486A1 (en) 2000-07-17 2002-01-30 Labnetics, Inc. Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities
JP2004516863A (ja) 2000-07-24 2004-06-10 モトローラ・インコーポレイテッド 摂取可能な電子カプセル
US7255833B2 (en) 2000-07-25 2007-08-14 Cepheid Apparatus and reaction vessel for controlling the temperature of a sample
JP2002044007A (ja) 2000-07-26 2002-02-08 Ricoh Elemex Corp 携帯電話機
US20040005582A1 (en) 2000-08-10 2004-01-08 Nanobiodynamics, Incorporated Biospecific desorption microflow systems and methods for studying biospecific interactions and their modulators
US6905886B2 (en) 2000-08-11 2005-06-14 Quest Diagnostics Investments Incorporated Preservative solutions
US6797518B1 (en) * 2000-09-11 2004-09-28 Ortho-Clinical Diagnostics, Inc. Analysis method with sample quality measurement
DE10046110B8 (de) 2000-09-18 2006-07-06 Siemens Ag Medizinisches Diagnosegerät mit Patientenerkennung
EP1328312A4 (en) 2000-09-27 2007-08-01 Cobe Cardiovascular Inc blood perfusion system
US6689615B1 (en) 2000-10-04 2004-02-10 James Murto Methods and devices for processing blood samples
CA2360194C (en) 2000-10-25 2008-10-07 Micronix, Inc. A solid state microcuvette using dry films
WO2002079762A2 (en) 2000-10-27 2002-10-10 Dumas David P Apparatus for fluorescence detection on arrays
JP4015946B2 (ja) 2000-10-30 2007-11-28 シークエノム・インコーポレーテツド 基板上にサブマイクロリットルの体積を供給する方法及び装置
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US7026131B2 (en) 2000-11-17 2006-04-11 Nagaoka & Co., Ltd. Methods and apparatus for blood typing with optical bio-discs
AU2001295361A1 (en) 2000-11-17 2002-05-27 Tecan Trading Ag Method and device for determining the volume of a sample of a liquid
US6905816B2 (en) 2000-11-27 2005-06-14 Intelligent Medical Devices, Inc. Clinically intelligent diagnostic devices and methods
JP2002161856A (ja) 2000-11-28 2002-06-07 Matsushita Electric Ind Co Ltd シャフトおよびシャフトの製造方法
EP1340068A2 (en) 2000-12-01 2003-09-03 Cetek Corporation High throughput capillary electrophoresis system
CA2430868A1 (en) * 2000-12-12 2002-06-20 Australian Institute Of Marine Science Assay for paralytic shellfish toxin
DK1363736T3 (da) 2000-12-18 2011-06-27 Protedyne Corp Ekstrudering af gelmateriale til gelelektroforese
GB0030929D0 (en) 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US6312929B1 (en) 2000-12-22 2001-11-06 Cepheid Compositions and methods enabling a totally internally controlled amplification reaction
AU2002243360A1 (en) 2000-12-26 2002-08-06 C. Frederick Battrell Microfluidic cartridge with integrated electronics
US6870797B2 (en) 2001-01-04 2005-03-22 Hewlett-Packard Development Company, L.P. Media storage system using a transponder for transmitting data signal
US7205157B2 (en) * 2001-01-08 2007-04-17 Becton, Dickinson And Company Method of separating cells from a sample
CA2366802A1 (en) 2001-01-17 2002-07-17 Bayer Corporation Method and apparatus for using infrared readings to detect misidentification of a diagnostic test strip in a reflectance spectrometer
US7315784B2 (en) 2001-02-15 2008-01-01 Siemens Aktiengesellschaft Network for evaluating data obtained in a biochip measurement device
US6484104B2 (en) 2001-02-15 2002-11-19 Klaus Abraham-Fuchs Network for evaluating data obtained in a biochip measurement device
US7567913B2 (en) 2001-02-16 2009-07-28 Quest Diagnostics Inc. Method and system for ordering a laboratory test for a patient and obtaining results thereof
US6612985B2 (en) 2001-02-26 2003-09-02 University Of Rochester Method and system for monitoring and treating a patient
US6899848B1 (en) 2001-02-27 2005-05-31 Hamilton Company Automated sample treatment system: apparatus and method
US6341490B1 (en) 2001-03-03 2002-01-29 Gilson, Inc. Heat transfer apparatus for sample containing well plates
US6949377B2 (en) 2001-03-05 2005-09-27 Ho Winston Z Chemiluminescence-based microfluidic biochip
JP2002266762A (ja) 2001-03-07 2002-09-18 Matsushita Electric Ind Co Ltd 冷凍サイクル装置
JP4542312B2 (ja) 2001-03-09 2010-09-15 ニューゲン テクノロジーズ， インコーポレイテッド Ｒｎａ配列の増幅のための方法および組成物
WO2002072265A1 (en) 2001-03-09 2002-09-19 Gen-Probe Incorporated Penetrable cap
JP2002263185A (ja) 2001-03-12 2002-09-17 Sanyo Electric Co Ltd 投薬システム及び方法及び投薬装置
US6748337B2 (en) 2001-03-14 2004-06-08 Wardlaw Partners, Lp Method and apparatus for providing quality control in an instrument for medical analysis
JP2002282217A (ja) 2001-03-27 2002-10-02 Sysmex Corp 測定装置及びそれを含む測定結果管理システム
US7010391B2 (en) 2001-03-28 2006-03-07 Handylab, Inc. Methods and systems for control of microfluidic devices
JP2002291954A (ja) 2001-04-02 2002-10-08 Ntk:Kk ゴルフ練習場のピン装置
US20040044560A1 (en) 2001-04-05 2004-03-04 Joe Giglio Kiosk with body fat analyzer
US7458483B2 (en) 2001-04-24 2008-12-02 Abbott Laboratories, Inc. Assay testing diagnostic analyzer
WO2002089767A1 (en) 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US20030211618A1 (en) 2001-05-07 2003-11-13 Patel Gordhandhai Nathalal Color changing steam sterilization indicator
MXPA03010209A (es) 2001-05-09 2004-03-16 Axis Shield Asa Sistema de analisis.
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US20050009101A1 (en) 2001-05-17 2005-01-13 Motorola, Inc. Microfluidic devices comprising biochannels
US6919046B2 (en) 2001-06-07 2005-07-19 Nanostream, Inc. Microfluidic analytical devices and methods
JP2002371955A (ja) 2001-06-15 2002-12-26 Sanuki Kogyo Kk 往復駆動装置及び該装置を使用した送液ポンプ
DK2420824T3 (en) 2001-06-29 2019-03-25 Meso Scale Technologies Llc Multi-well plate with an array of wells and kit for use in performing an ECL assay
AUPR604101A0 (en) 2001-06-29 2001-07-26 Unisearch Limited Aptamers
US20030208113A1 (en) 2001-07-18 2003-11-06 Mault James R Closed loop glycemic index system
US6833441B2 (en) 2001-08-01 2004-12-21 Abmaxis, Inc. Compositions and methods for generating chimeric heteromultimers
CN1279357C (zh) * 2001-08-10 2006-10-11 松下电器产业株式会社 生物传感器及使用它的血液成分分析方法
CN101684161A (zh) 2001-08-10 2010-03-31 阿赫姆生物系统公司 蛋白酶检测系统
US6636623B2 (en) * 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
JP3775263B2 (ja) 2001-08-10 2006-05-17 ニプロ株式会社 記録媒体およびこの記録媒体を用いた血糖測定システム
US6751491B2 (en) 2001-09-01 2004-06-15 M Biotech Inc Analyte measuring biosensor chip using image scanning system
US20030052074A1 (en) 2001-09-17 2003-03-20 Chang Min Shuan Closure for container for holding biological samples
US7854896B2 (en) 2001-09-25 2010-12-21 Becton, Dickinson And Company Closed system storage plates
JP4754746B2 (ja) 2001-09-28 2011-08-24 オリンパス株式会社 棒状担体およびこれを具備するシリンダー反応容器
US6805842B1 (en) 2001-10-12 2004-10-19 Mds Sciex Repuncturable self-sealing sample container with internal collapsible bag
US20060121502A1 (en) 2001-11-09 2006-06-08 Robert Cain Microfluidics apparatus for cantilevers and methods of use therefor
JP2003222611A (ja) 2001-11-20 2003-08-08 Nec Corp 分離装置、分離方法および分離装置の製造方法
US7635588B2 (en) 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
JP2003166910A (ja) 2001-11-30 2003-06-13 Asahi Kasei Corp 送液機構及び該送液機構を備える分析装置
JP2003167960A (ja) 2001-12-04 2003-06-13 Ikuo Kondo 健康管理システム
US20050027182A1 (en) 2001-12-27 2005-02-03 Uzair Siddiqui System for monitoring physiological characteristics
US6583879B1 (en) 2002-01-11 2003-06-24 X-Rite, Incorporated Benchtop spectrophotometer with improved targeting
JP2003207454A (ja) 2002-01-15 2003-07-25 Minolta Co Ltd 透過光検出装置
US7133547B2 (en) * 2002-01-24 2006-11-07 Tripath Imaging, Inc. Method for quantitative video-microscopy and associated system and computer software program product
US20030175164A1 (en) 2002-01-25 2003-09-18 Irm, Llc Devices, systems, and methods of manifolding materials
FI112093B (fi) 2002-01-30 2003-10-31 Boreal Plant Breeding Ltd Menetelmä ja testipakkaus geneettisen identiteetin osoittamiseksi
US20040109793A1 (en) 2002-02-07 2004-06-10 Mcneely Michael R Three-dimensional microfluidics incorporating passive fluid control structures
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
US20030212379A1 (en) 2002-02-26 2003-11-13 Bylund Adam David Systems and methods for remotely controlling medication infusion and analyte monitoring
CA2419200C (en) 2002-03-05 2015-06-30 Bayer Healthcare Llc Fluid collection apparatus having an integrated lance and reaction area
JP2003315348A (ja) 2002-04-22 2003-11-06 Hitachi High-Technologies Corp 検体処理システム及びそれを用いた検体検査自動化システム
WO2003090614A1 (fr) 2002-04-25 2003-11-06 Matsushita Electric Industrial Co., Ltd. Dispositif de determination de dose, injecteur et systeme de gestion sanitaire
JP2003322653A (ja) 2002-05-07 2003-11-14 Toshiba Corp プローブ固定支持体及びプローブ固定担体
US20030143113A2 (en) 2002-05-09 2003-07-31 Lifescan, Inc. Physiological sample collection devices and methods of using the same
JP3839349B2 (ja) 2002-05-15 2006-11-01 株式会社堀場製作所 化学発光酵素免疫測定装置
KR20050008720A (ko) 2002-05-17 2005-01-21 벡톤 디킨슨 앤드 컴퍼니 표적 핵산 서열의 분리, 증폭 및 검출을 위한 자동화 시스템
US7055368B2 (en) 2002-05-21 2006-06-06 Kendro Laboratory Products, Inc. Automatic calibration of an imbalance detector
AU2003232169B8 (en) 2002-06-11 2008-05-08 Koninklijke Philips Electronics N.V. A disposable cartridge for characterizing particles suspended in a liquid
US7272252B2 (en) 2002-06-12 2007-09-18 Clarient, Inc. Automated system for combining bright field and fluorescent microscopy
FR2841249A1 (fr) 2002-06-19 2003-12-26 Genfit S A Compositions et methodes pour le dosage de l'apo b48 et de l'apo b100
JP4106977B2 (ja) 2002-06-21 2008-06-25 株式会社日立製作所 分析チップ及び分析装置
US6730510B2 (en) 2002-07-02 2004-05-04 Organogenesis, Inc. Culture dish and bioreactor system
WO2004008112A1 (de) * 2002-07-12 2004-01-22 Abb Research Ltd Hochauflösendes absorptionsspektrometer und entsprechendes messverfahren
EP1539352B1 (en) 2002-07-23 2009-12-23 Protedyne Corporation Liquid handling tool having hollow plunger
FR2842912B1 (fr) 2002-07-25 2004-09-10 Junior Instruments Procede et dispositf pour le pretraitement par centrifugeage d'echantillons.
US20040029266A1 (en) 2002-08-09 2004-02-12 Emilio Barbera-Guillem Cell and tissue culture device
US8200438B2 (en) 2002-08-19 2012-06-12 Escreen, Inc. Method and computer program for creating electronic custody and control forms for human assay test samples
US6780645B2 (en) 2002-08-21 2004-08-24 Lifescan, Inc. Diagnostic kit with a memory storing test strip calibration codes and related methods
CN2559986Y (zh) 2002-08-23 2003-07-09 上海博昇微晶科技有限公司 集成微流体和微阵列探针的微芯片
US7188731B2 (en) 2002-08-26 2007-03-13 The Regents Of The University Of California Variable flexure-based fluid filter
US20070166725A1 (en) 2006-01-18 2007-07-19 The Regents Of The University Of California Multiplexed diagnostic platform for point-of care pathogen detection
US20040038385A1 (en) 2002-08-26 2004-02-26 Langlois Richard G. System for autonomous monitoring of bioagents
JP2004101381A (ja) * 2002-09-10 2004-04-02 Nittec Co Ltd 自動分析装置用の複光路セル及びこの複光路セルを用いた分析方法
EP1539979B1 (en) 2002-09-20 2008-11-19 New England Biolabs, Inc. Helicase dependent amplification of nucleic acids
US7177767B2 (en) 2002-10-18 2007-02-13 Abaxis, Inc. Systems and methods for the detection of short and long samples
US20040086872A1 (en) 2002-10-31 2004-05-06 Childers Winthrop D. Microfluidic system for analysis of nucleic acids
US7390457B2 (en) 2002-10-31 2008-06-24 Agilent Technologies, Inc. Integrated microfluidic array device
JP2006505283A (ja) 2002-11-08 2006-02-16 フアルマシア・コーポレーシヨン 高速処理自動化核酸単離及び定量法
US6915919B2 (en) 2002-11-21 2005-07-12 American Bio Medica Corporation Container closure cap with self-sealing slot
JP3799323B2 (ja) 2002-11-29 2006-07-19 Ｎｅｃインフロンティア株式会社 情報端末装置及びｐｃカード
WO2004055198A2 (en) 2002-12-12 2004-07-01 Chiron Corporation Device and method for in-line blood testing using biochips
CN1173182C (zh) 2002-12-18 2004-10-27 陕西超英生物医学研究开发有限公司 糖尿病自身免疫抗体检测蛋白芯片、其制备及检测方法
US20040120848A1 (en) 2002-12-20 2004-06-24 Maria Teodorczyk Method for manufacturing a sterilized and calibrated biosensor-based medical device
US7110107B2 (en) 2002-12-20 2006-09-19 Corning Incorporated Capillary assay device and method
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
US20060094108A1 (en) 2002-12-20 2006-05-04 Karl Yoder Thermal cycler for microfluidic array assays
CA3171720C (en) 2002-12-26 2024-01-09 Meso Scale Technologies, Llc. Methods for conducting electrochemiluminescence measurements
DE10307030A1 (de) 2003-02-20 2004-09-09 Eppendorf Ag Dosiersystem
GB0303913D0 (en) * 2003-02-21 2003-03-26 Sophion Bioscience As Robot centrifugation device
DE10312197A1 (de) 2003-03-19 2004-09-30 Roche Diagnostics Gmbh Probenbehandlungsgerät, insbesondere automatisches Analysegerät
JP4464172B2 (ja) 2003-03-31 2010-05-19 キヤノン株式会社 生化学反応カートリッジ及びその使用方法
WO2004087322A2 (en) 2003-04-04 2004-10-14 Koninklijke Philips Electronics N.V. Fluid partitioning in multiple microchannels
US20050010098A1 (en) 2003-04-11 2005-01-13 Sigmund Frigstad Method and apparatus for knowledge based diagnostic imaging
JP4260541B2 (ja) 2003-05-12 2009-04-30 旭化成ファーマ株式会社 糖化タンパク質測定用試験片
US20040230400A1 (en) 2003-05-13 2004-11-18 Tomasso David Angelo Analyzer having concentric rotors
US20040228766A1 (en) 2003-05-14 2004-11-18 Witty Thomas R. Point of care diagnostic platform
AU2003902422A0 (en) 2003-05-19 2003-06-05 Intellirad Solutions Pty. Ltd Access security system
US7185551B2 (en) 2003-05-22 2007-03-06 Schwartz H Donald Pipetting module
US20040241048A1 (en) 2003-05-30 2004-12-02 Applera Corporation Thermal cycling apparatus and method for providing thermal uniformity
CA2527342A1 (en) 2003-06-05 2004-12-16 Bioprocessors Corp. System and method for process automation
US7258673B2 (en) 2003-06-06 2007-08-21 Lifescan, Inc Devices, systems and methods for extracting bodily fluid and monitoring an analyte therein
US7604592B2 (en) 2003-06-13 2009-10-20 Pelikan Technologies, Inc. Method and apparatus for a point of care device
US7702524B1 (en) 2003-06-16 2010-04-20 Scheduling.Com, Inc. Method and system for online secure patient referral system
EP1637881B1 (en) * 2003-06-20 2012-05-02 Universal Bio Research Co., Ltd. Sample arraying/assembling device, its method, and apparatus using sample assembly
JP3918178B2 (ja) 2003-06-23 2007-05-23 大阪瓦斯株式会社 高純度ナノスケールカーボンチューブ含有炭素質材料の製造法
JP3566277B1 (ja) * 2003-06-23 2004-09-15 株式会社日立製作所 血糖値測定装置
US7824623B2 (en) 2003-06-24 2010-11-02 Millipore Corporation Multifunctional vacuum manifold
US20050009191A1 (en) 2003-07-08 2005-01-13 Swenson Kirk D. Point of care information management system
JP2005030983A (ja) 2003-07-09 2005-02-03 Matsushita Electric Ind Co Ltd 測定装置
JP4087302B2 (ja) 2003-07-10 2008-05-21 日本電子株式会社 検査装置
JP4531698B2 (ja) 2003-07-17 2010-08-25 三菱化学メディエンス株式会社 自動測定用カートリッジおよびそれを用いる測定装置
US7860727B2 (en) 2003-07-17 2010-12-28 Ventana Medical Systems, Inc. Laboratory instrumentation information management and control network
US7381370B2 (en) 2003-07-18 2008-06-03 Dade Behring Inc. Automated multi-detector analyzer
JP3888342B2 (ja) 2003-08-29 2007-02-28 ブラザー工業株式会社 ネットワーク装置
EP1670356A1 (en) 2003-09-03 2006-06-21 Life Patch International, Inc. Personal diagnostic devices and related methods
JPWO2005024437A1 (ja) 2003-09-05 2007-11-08 日本電気株式会社 測定システム
US20050074873A1 (en) 2003-09-09 2005-04-07 Shanler Michael S. Tissue culture vessel
EP2486980B1 (en) 2003-09-09 2014-12-03 BioGenex Laboratories Sample processing system
US7682833B2 (en) 2003-09-10 2010-03-23 Abbott Point Of Care Inc. Immunoassay device with improved sample closure
KR101556457B1 (ko) 2003-09-11 2015-10-01 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기
US20060115384A1 (en) 2003-09-16 2006-06-01 Vici Gig Harbor Group, Inc. Pipette tip surface sorption extraction
US20050225751A1 (en) 2003-09-19 2005-10-13 Donald Sandell Two-piece high density plate
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
DE10344700A1 (de) 2003-09-26 2005-04-14 Hirschmann Laborgeräte GmbH & Co. KG Mehrkanal-Pipettiervorrichtung
JP2005104750A (ja) 2003-09-29 2005-04-21 Matsushita Electric Ind Co Ltd ナノチューブの精製方法
WO2005030399A1 (ja) * 2003-09-30 2005-04-07 Kabushiki Kaisha Kitazato Supply 遠心分離用沈殿管および生体細胞採取用チューブ
EP1520514A1 (en) * 2003-10-02 2005-04-06 Matsushita Electric Industrial Co., Ltd. Optical biological information measuring apparatus and method
JP4441618B2 (ja) 2003-10-06 2010-03-31 独立行政法人産業技術総合研究所 インフルエンザウイルスの検出方法
WO2005037293A1 (en) 2003-10-16 2005-04-28 Univ Monash Immunomodulating compositions and uses therefor
DE602004013176T2 (de) 2003-10-28 2009-06-18 Diesse Diagnostica Senese S.P.A. Vorrichtung zur durchführung von analysen in biologischen flüssigkeiten und damit verbundenes verfahren
JP4073023B2 (ja) 2003-11-07 2008-04-09 財団法人新産業創造研究機構 微小流路デバイスおよびその作製方法
US8615282B2 (en) 2004-07-13 2013-12-24 Dexcom, Inc. Analyte sensor
EP1694210B1 (en) 2003-11-26 2012-03-28 Koninklijke Philips Electronics N.V. Workflow optimization for high throughput imaging environment
WO2005121780A2 (en) 2003-12-09 2005-12-22 Board Of Regents, The University Of Texas System Methods and apparatus for characterizing, measuring, and dispensing fluids
EP1702211A2 (en) 2003-12-23 2006-09-20 Fastraq, Inc. Point of care diagnostic platform
JP4646809B2 (ja) 2003-12-26 2011-03-09 パナソニック株式会社 生体サンプル判別装置、生体サンプル判別方法、及び生体サンプル判別用プレート
JP4057539B2 (ja) * 2004-01-09 2008-03-05 浜松ホトニクス株式会社 シースフローセルキュベット及びその製造方法
US7150995B2 (en) 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
US20050164204A1 (en) 2004-01-27 2005-07-28 Reed Thomas D. Single use lyophilized rnase reagents, and kits and methods for using same
HUE037253T2 (hu) 2004-01-27 2018-08-28 Altivera L L C Diagnosztikus rádiófrekvenciás azonosító szenzorok és ezek alkalmazásai
US20050227370A1 (en) 2004-03-08 2005-10-13 Ramel Urs A Body fluid analyte meter & cartridge system for performing combined general chemical and specific binding assays
JP2005291954A (ja) 2004-03-31 2005-10-20 Olympus Corp 使い捨て試薬パックとその試薬パックを用いる分析装置
DE602004014898D1 (de) 2004-03-31 2008-08-21 Roche Diagnostics Gmbh Modulare Analysevorrichtung
JP2007532878A (ja) 2004-04-06 2007-11-15 バイオ／データ・コーポレイション 使い捨て試験装置と検体量測定／混合方法
US20080166753A1 (en) 2004-04-12 2008-07-10 University Technologies International Inc. Microbial Growth Assay
US20050236317A1 (en) 2004-04-23 2005-10-27 Millipore Corporation Pendant drop control in a multiwell plate
US7887750B2 (en) 2004-05-05 2011-02-15 Bayer Healthcare Llc Analytical systems, devices, and cartridges therefor
US7494791B2 (en) 2004-05-13 2009-02-24 Nanobiosym, Inc. Nano-PCR: methods and devices for nucleic acid amplification and detection
US8323564B2 (en) 2004-05-14 2012-12-04 Honeywell International Inc. Portable sample analyzer system
FR2871150B1 (fr) 2004-06-04 2006-09-22 Univ Lille Sciences Tech Dispositif de manipulation de gouttes destine a l'analyse biochimique, procede de fabrication du dispositif, et systeme d'analyse microfluidique
US8211386B2 (en) 2004-06-08 2012-07-03 Biokit, S.A. Tapered cuvette and method of collecting magnetic particles
TWI547431B (zh) * 2004-06-09 2016-09-01 史密斯克萊美占公司 生產藥物之裝置及方法
WO2005124366A1 (en) 2004-06-14 2005-12-29 Parker-Hannifin Corporation Robotic handling system and method with independently operable detachable tools
US20060057559A1 (en) 2004-06-23 2006-03-16 Rigel Pharmaceuticals, Inc. High-throughput cell migration screening assay
JP4416579B2 (ja) 2004-06-23 2010-02-17 株式会社日立ハイテクノロジーズ 自動分析装置
US7609654B2 (en) 2004-07-01 2009-10-27 Mcdata Corporation Method of evaluating network connectivity between network resources
WO2006003551A1 (en) 2004-07-02 2006-01-12 Koninklijke Philips Electronics N.V. Spectroscopic system with multiple probes
US7196719B2 (en) 2004-07-16 2007-03-27 Vision Robotics Corporation Angled axis machine vision system and method
CN101010579A (zh) * 2004-07-27 2007-08-01 株式会社三菱化学药得论 被检试样的自动判别方法
US20060026040A1 (en) 2004-07-28 2006-02-02 Reeves Anthony P System and method for providing remote analysis of medical data
EP1626281A1 (en) 2004-08-03 2006-02-15 The Automation Partnership (Cambridge) Limited Pipetting device
TWI392863B (zh) * 2004-08-05 2013-04-11 Universal Bio Research Co Ltd 反應容器、反應容器液體導入裝置、液體導入反應測定裝置及液體導入裝置
US7690275B1 (en) 2004-08-26 2010-04-06 Elemental Scientific, Inc. Automated sampling device
WO2006025703A1 (en) 2004-09-02 2006-03-09 Bioneer Corporation Miniaturized apparatus for real-time monitoring
CN1311239C (zh) 2004-09-07 2007-04-18 李人 免疫层析测试条及其制造方法
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
US7744821B2 (en) 2004-09-21 2010-06-29 Andreas Hettich Gmbh & Co. Kg Blood bag cup for centrifuges
AT500882A3 (de) 2004-10-06 2009-12-15 Greiner Bio One Gmbh In-vitro diagnostikum zur speichelvolumsbestimmung
JP2006125855A (ja) 2004-10-26 2006-05-18 Kusano Kagaku:Kk 分注装置
US20060095429A1 (en) 2004-10-29 2006-05-04 Eastman Kodak Company Networked system for routing medical images
JP4424158B2 (ja) * 2004-11-04 2010-03-03 ソニー株式会社 バイオアッセイ装置とバイオアッセイ方法
US7604985B2 (en) 2004-11-10 2009-10-20 Becton, Dickinson And Company System and method for determining fill volume in a container
US20120053068A1 (en) 2004-11-18 2012-03-01 Eppendorf Array Technologies Real-time pcr of targets on a micro-array
US20060111620A1 (en) 2004-11-23 2006-05-25 Squilla John R Providing medical services at a kiosk
CN101099104B (zh) * 2004-11-24 2010-10-27 巴特尔纪念研究所 用于细胞成像的光学系统
KR100601974B1 (ko) 2004-11-25 2006-07-18 삼성전자주식회사 비드의 상이한 레이저 흡수에 의한 핵산의 정제 장치 및방법
KR100581356B1 (ko) 2004-11-25 2006-05-17 재단법인서울대학교산학협력재단 싸이토메트리, 빌로시메트리 및 세포 분류에 사용하기위한 폴리전해질 염다리를 사용하는 마이크로칩
US20060121491A1 (en) 2004-12-02 2006-06-08 Wolber Paul K Partially degenerate oligonucleotide standards and methods for generating the same
US7479391B2 (en) * 2004-12-10 2009-01-20 Tecan Trading Ag Pipetting apparatus with integrated liquid level and/or gas bubble detection
US7978665B1 (en) 2004-12-13 2011-07-12 Verizon Laboratories Inc. Systems and methods for providing connection status and location information in a wireless networking environment
DE602005027907D1 (de) * 2004-12-13 2011-06-16 Bayer Healthcare Llc Transmissionspektroskopiesystem zur verwendung bei der bestimmung von analyten in körperflüssigkeit
ITMI20042434A1 (it) 2004-12-21 2005-03-21 Paolo Giordano Metodo e dispositivo per l'estrazione rapida di antigeni
JP4203469B2 (ja) 2004-12-24 2009-01-07 アロカ株式会社 液体試料の攪拌装置
WO2006079814A2 (en) 2005-01-26 2006-08-03 Enigma Diagnostics Ltd Method for carrying out a multi-step reaction, breakable container for storing reagents and method for transferring solid reagent using an electrostatically charged wand
US8614101B2 (en) 2008-05-20 2013-12-24 Rapid Pathogen Screening, Inc. In situ lysis of cells in lateral flow immunoassays
US7481787B2 (en) 2005-02-14 2009-01-27 Optiscan Biomedical Corporation Fluid handling cassette having a spectroscopic sample cell
WO2006087574A2 (en) 2005-02-19 2006-08-24 Geneform Technologies Limited Isothermal nucleic acid amplification
GB0503836D0 (en) 2005-02-24 2005-04-06 Axis Shield Asa Method
JP2006276003A (ja) 2005-03-03 2006-10-12 Juki Corp 分注装置
CA2600934A1 (en) 2005-03-07 2006-09-14 Novx Systems Inc. Automated analyzer
EP2322940B1 (en) 2005-03-10 2014-10-29 Gen-Probe Incorporated Systems amd methods to perform assays for detecting or quantifing analytes within samples
US7650395B2 (en) 2005-03-18 2010-01-19 Microsoft Corporation Network connectivity management
US20060223178A1 (en) 2005-04-05 2006-10-05 Tom Barber Devices and methods for magnetic enrichment of cells and other particles
WO2006116718A2 (en) 2005-04-28 2006-11-02 Proteus Biomedical, Inc. Pharma-informatics system
CN101535499B (zh) 2005-05-09 2017-04-19 赛拉诺斯股份有限公司 点护理流体系统及其应用
EP3714979A1 (en) 2005-05-09 2020-09-30 BioFire Diagnostics, LLC Self-contained biological analysis
GB2425974A (en) 2005-05-09 2006-11-15 Orion Diagnostica Oy Sonication of a medium
IES20050304A2 (en) 2005-05-11 2006-11-15 Haemoglobal Biotech Ltd A mobile chemistry and haematology analyser with an intergrated diagnostic databank
JP4520359B2 (ja) 2005-05-13 2010-08-04 日立ソフトウエアエンジニアリング株式会社 粒子捕捉装置、並びに粒子配列方法及び粒子配列装置
JP4657803B2 (ja) 2005-05-19 2011-03-23 富士フイルム株式会社 送液システム及びその送液方法並びに流路ユニット。
GB0510362D0 (en) * 2005-05-20 2005-06-29 Univ Greenwich Device for detecting mycotoxins
WO2007002579A2 (en) 2005-06-23 2007-01-04 Bioveris Corporation Assay cartridges and methods for point of care instruments
AU2006261953B2 (en) 2005-06-24 2012-02-23 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
WO2007000966A1 (ja) * 2005-06-27 2007-01-04 Sekisui Chemical Co., Ltd. 検体採取容器
US20070004577A1 (en) 2005-06-29 2007-01-04 Gabor Lederer Centrifuge assembly
US7663750B2 (en) 2005-06-30 2010-02-16 Applied Biosystems, Llc Two-dimensional spectral imaging system
JP2007017354A (ja) 2005-07-08 2007-01-25 Sumitomo Bakelite Co Ltd 化学反応検出システム
JP2007024851A (ja) 2005-07-16 2007-02-01 Adobic:Kk 検体分析チップおよび検体分析チップの使用方法
US7422554B2 (en) 2005-08-10 2008-09-09 The Drucker Company, Inc. Centrifuge with aerodynamic rotor and bucket design
BRPI0621957A2 (pt) 2005-08-24 2011-12-27 Telechemistry Oy mÉtodo para testar uma amostra lÍquida, unidade de teste e um sistema automatizado de uma pluralidade de unidades de teste
WO2007037410A1 (ja) * 2005-09-30 2007-04-05 Pulse-Immunotech Corporation 血球成分を破壊する工程を含む試料中の親和性物質の測定方法
FR2891625B1 (fr) 2005-10-03 2007-12-21 Francois Melet Analyseur compact de biochimie seche pour l'analyse d'echantillons sanguins.
US7733224B2 (en) 2006-06-30 2010-06-08 Bao Tran Mesh network personal emergency response appliance
US8652421B2 (en) 2005-11-03 2014-02-18 Emd Millipore Corporation Immunoassay product and process
US7581660B2 (en) 2005-11-09 2009-09-01 Hamilton Bonaduz Ag Drip-resistant pipetting device and drip-resistant pipetting method
GB0523231D0 (en) * 2005-11-15 2005-12-21 Redfern Jonathan Liquid photometer using disposable pipette tip vessel
US20070118399A1 (en) 2005-11-22 2007-05-24 Avinash Gopal B System and method for integrated learning and understanding of healthcare informatics
EP1969153A2 (en) 2005-11-28 2008-09-17 Pacific Biosciences of California, Inc. Uniform surfaces for hybrid material substrates and methods for making and using same
GB2432660A (en) 2005-11-29 2007-05-30 Bacterioscan Ltd System for counting bacteria and determining their susceptibility to antibiotics
JP2007152157A (ja) 2005-11-30 2007-06-21 Hitachi Koki Co Ltd 遠心機
US20070125677A1 (en) 2005-12-06 2007-06-07 Neil Oronsky Thermal and/or light protective container assemblies and their methods of use
WO2007067999A2 (en) 2005-12-09 2007-06-14 Amnis Corporation Extended depth of field imaging for high speed object analysis
CN102841195B (zh) 2005-12-21 2016-02-03 梅索斯卡莱科技公司 具有分析试剂的分析模块及其制备和使用方法
CN101379404A (zh) * 2005-12-22 2009-03-04 霍尼韦尔国际公司 具有活动式盒的血液学分析仪系统
JP2007178328A (ja) 2005-12-28 2007-07-12 Shimadzu Corp 反応容器キット及び反応容器処理装置
WO2007078850A2 (en) 2005-12-29 2007-07-12 I-Stat Corporation Molecular diagnostics amplification system and methods
AU2007282135C1 (en) 2006-01-18 2012-05-24 Coimmune, Inc. Systems and methods for processing samples in a closed container, and related devices
US7876935B2 (en) 2006-01-30 2011-01-25 Protedyne Corporation Sample processing apparatus with a vision system
US7711800B2 (en) 2006-01-31 2010-05-04 Microsoft Corporation Network connectivity determination
WO2007092713A2 (en) 2006-02-02 2007-08-16 Trustees Of The University Of Pennsylvania Microfluidic system and method for analysis of gene expression in cell-containing samples and detection of disease
US20070192138A1 (en) 2006-02-16 2007-08-16 Motoaki Saito Medical record system in a wide-area network environment
EP1993434A2 (en) 2006-03-10 2008-11-26 Hadas Lewy Automated sampling and analysis using a personal sampler device
WO2007105726A1 (ja) 2006-03-14 2007-09-20 Nemoto Kyorindo Co., Ltd. 医療画像システム
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
DK2001990T3 (en) 2006-03-24 2016-10-03 Handylab Inc Integrated microfluidic sample processing system and method for its use
BRPI0710289A2 (pt) 2006-04-24 2011-08-09 Richard Fuisz analizador de fluido corporal, e sistema de inclusão do mesmo e método para programação do mesmo
JP2009535635A (ja) 2006-05-03 2009-10-01 エヌツェーエル ニュー コンセプト ラブ ゲーエムベーハー 化学的、生化学的、生物学的および物理学的分析、反応、アッセイなどのためのデバイスおよび方法
US8007999B2 (en) 2006-05-10 2011-08-30 Theranos, Inc. Real-time detection of influenza virus
CA2657970A1 (en) 2006-05-17 2007-11-29 Luminex Corporation Chip-based flow cytometer type systems for analyzing fluorescently tagged particles
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
JP2007309889A (ja) 2006-05-22 2007-11-29 Olympus Corp 異物検出装置及び異物検出方法
JP2007322324A (ja) 2006-06-02 2007-12-13 Olympus Corp 分析装置
ATE452336T1 (de) 2006-06-06 2010-01-15 Hoffmann La Roche Gebrauchsfertiges sammelgefäss für vollblut
KR100772969B1 (ko) * 2006-06-08 2007-11-02 양현진 원심분리기 및 원심분리방법
US20080026483A1 (en) 2006-06-14 2008-01-31 Oldenburg Kevin R Thermal-cycling devices and methods of using the same
JP2008002897A (ja) * 2006-06-21 2008-01-10 Olympus Corp 分注装置および自動分析装置
AU2007269654B2 (en) * 2006-06-30 2013-01-10 University Of Southern California Quantifiable internal reference standards for immunohistochemistry and uses thereof
US7972786B2 (en) 2006-07-07 2011-07-05 Brandeis University Detection and analysis of influenza virus
CA2657652C (en) 2006-07-13 2015-05-12 Jody Ann Tirinato Medical data acquisition and patient management system and method
SE531041C2 (sv) * 2006-07-17 2008-11-25 Hemocue Ab Räkning av trombocyter
SE530192C2 (sv) 2006-07-19 2008-03-25 Hemocue Ab Apparat för avbildning av prov där provhållaren är flyttbar medelst magnetisk växelverkan
DE102006034245C5 (de) 2006-07-21 2014-05-28 Stratec Biomedical Systems Ag Positioniereinrichtung zur Positionierung von Pipetten
EP1882948A2 (de) 2006-07-28 2008-01-30 Qiagen GmbH Vorrichtung zur Probenverarbeitung
EP1892531B1 (en) * 2006-08-22 2017-04-05 Sysmex Corporation Sample analyzer
JP4979305B2 (ja) 2006-08-22 2012-07-18 シスメックス株式会社 分析装置
US7787681B2 (en) * 2006-08-25 2010-08-31 The Trustees Of Columbia University In The City Of New York Systems and methods for robotic transport
JP2008064701A (ja) 2006-09-11 2008-03-21 Matsushita Electric Ind Co Ltd 回転分析デバイス及び計量方法及び検査方法
US20100240544A1 (en) 2006-09-29 2010-09-23 Liu David J Aptamer biochip for multiplexed detection of biomolecules
US9128084B2 (en) 2006-10-12 2015-09-08 Koninklijke Philips N.V. Fast biosensor with reagent layer
US7662344B2 (en) 2006-10-24 2010-02-16 Viaflo Corporation Locking pipette tip and mounting shaft
US20110001036A1 (en) 2006-10-24 2011-01-06 Koninklijke Philips Electronics N.V. system for imaging an object
US7312042B1 (en) 2006-10-24 2007-12-25 Abbott Diabetes Care, Inc. Embossed cell analyte sensor and methods of manufacture
US7662343B2 (en) 2006-10-24 2010-02-16 Viaflo Corporation Locking pipette tip and mounting shaft
WO2008070352A2 (en) 2006-10-27 2008-06-12 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
US20080153096A1 (en) 2006-11-02 2008-06-26 Vectrant Technologies Inc. Cartridge for conducting diagnostic assays
US8012349B2 (en) * 2006-11-20 2011-09-06 Orbital Biosciences, Llc Small volume unitary molded filters and supports for adsorbent beds
DE102006057300A1 (de) 2006-12-05 2008-06-19 Siemens Ag Anordnung zur Aufbereitung einer Mehrzahl von Proben für eine Analyse
WO2008077007A1 (en) * 2006-12-19 2008-06-26 Cytyc Corporation Method for analyzing blood content of cytological specimens
GB0625595D0 (en) 2006-12-21 2007-01-31 Oxford Gene Tech Ip Ltd Sample analyser
US7955867B2 (en) 2007-01-31 2011-06-07 Millipore Corporation High throughput cell-based assays, methods of use and kits
WO2008115632A2 (en) 2007-02-09 2008-09-25 The Regents Of The University Of California Method for recombining dna sequences and compositions related thereto
US20090137047A1 (en) 2007-03-02 2009-05-28 John Frederick Regan Automated Diagnostic Kiosk for Diagnosing Diseases
US20080228107A1 (en) 2007-03-12 2008-09-18 Venkateshwara N Reddy Bio-testing booth
US8143554B2 (en) 2007-03-16 2012-03-27 Amerigon Incorporated Air warmer
US8557588B2 (en) * 2007-03-27 2013-10-15 Schlumberger Technology Corporation Methods and apparatus for sampling and diluting concentrated emulsions
US20090227005A1 (en) 2007-03-27 2009-09-10 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Methods for pathogen detection
US20080243394A1 (en) 2007-03-27 2008-10-02 Theranostics Llc System, method and computer program product for manipulating theranostic assays
GB0706281D0 (en) 2007-03-30 2007-05-09 Guy S And St Thomas Nhs Founda Apparatus and method for recovering fluid from a fluid absorbing element
US8877507B2 (en) 2007-04-06 2014-11-04 Qiagen Gaithersburg, Inc. Ensuring sample adequacy using turbidity light scattering techniques
WO2008127949A1 (en) * 2007-04-13 2008-10-23 Waters Investments Limited Vessel, dispensing devices, kits and methods for containing fluids
US8387811B2 (en) 2007-04-16 2013-03-05 Bd Diagnostics Pierceable cap having piercing extensions
WO2008130178A1 (en) 2007-04-23 2008-10-30 Jae Chern Yoo Remote medical-diagnosis system and method
US7999084B2 (en) * 2007-05-16 2011-08-16 Agilent Technologies, Inc. Devices and methods for reducing matrix effects
JP4876027B2 (ja) 2007-05-30 2012-02-15 株式会社日立ハイテクノロジーズ 分注装置
US20100174181A1 (en) 2007-05-30 2010-07-08 Nemoto Kyorindo Co., Ltd. Liquid injector, fluoroscopic imaging system, and computer program
EP2000528A1 (en) 2007-06-04 2008-12-10 The Automation Partnership (Cambridge) Limited Shaking apparatus for cell culture incubator or the like
CN103418295B (zh) 2007-06-21 2015-11-18 简.探针公司 用于混合检测腔室的内容物的仪器和方法
JP4982266B2 (ja) 2007-06-22 2012-07-25 株式会社日立ハイテクノロジーズ 分注処理装置
US20090004754A1 (en) 2007-06-26 2009-01-01 Oldenburg Kevin R Multi-well reservoir plate and methods of using same
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US9186677B2 (en) 2007-07-13 2015-11-17 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8287820B2 (en) 2007-07-13 2012-10-16 Handylab, Inc. Automated pipetting apparatus having a combined liquid pump and pipette head system
US20090148941A1 (en) 2007-07-30 2009-06-11 Peter Florez Disposable mini-bioreactor device and method
GB0715171D0 (en) 2007-08-03 2007-09-12 Enigma Diagnostics Ltd Sample processor
US8158430B1 (en) 2007-08-06 2012-04-17 Theranos, Inc. Systems and methods of fluidic sample processing
CN101802182A (zh) 2007-08-21 2010-08-11 诺达利蒂公司 用于诊断、预后和治疗方法的方法
US7843560B2 (en) 2007-08-31 2010-11-30 Dow Global Technologies Inc. Stable turbidity calibration standards
US8783484B2 (en) 2007-08-31 2014-07-22 Saint-Gobain Performance Plastics Corporation Septa
DK2657699T3 (en) * 2007-10-02 2017-07-10 Theranos Inc Modular point-of-care devices and their applications
WO2009046183A1 (en) * 2007-10-03 2009-04-09 3M Innovative Properties Company Microorganism concentration process
US9083722B2 (en) 2007-10-05 2015-07-14 Qualcomm Incorporated Session initiation protocol registration with ping
EP3192876A1 (en) 2007-10-10 2017-07-19 Pocared Diagnostics Ltd. System for conducting the identification of bacteria in urine
US7947234B2 (en) 2007-10-17 2011-05-24 Rainin Instrument, Llc Liquid end assembly for a handheld multichannel pipette with adjustable nozzle spacing
EP2212414A4 (en) 2007-10-23 2011-07-20 Lotus Bio Nymphaea Ltd TEST DEVICE FOR BIOLOGICAL SAMPLES
WO2009055052A2 (en) 2007-10-24 2009-04-30 Biomarker Strategies, Llc Improved methods and devices for cellular analysis
US20090117009A1 (en) 2007-11-02 2009-05-07 Richard Cote Multi-channel electronic pipettor
US20090124284A1 (en) 2007-11-14 2009-05-14 Shimon Scherzer System and method for providing seamless broadband internet access to web applications
US8057376B2 (en) * 2007-12-18 2011-11-15 Caridianbct, Inc. Blood processing apparatus with sealed diffuser in optical control apparatus
WO2009093306A1 (ja) 2008-01-22 2009-07-30 Shimadzu Corporation 液体採取装置、測定装置並びにそれらを備えた液体採取測定システム
US20090204435A1 (en) 2008-01-31 2009-08-13 Brian Gale System for automating medical imaging diagnostic service delivery
US8486333B2 (en) * 2008-02-04 2013-07-16 Micropoint Biosciences, Inc. Centrifugal fluid analyzer rotor
JP5309160B2 (ja) 2008-02-05 2013-10-09 ポカード・ディアグノスティクス・リミテッド 生体サンプル中のバクテリアの同定を行うシステム
US20090203531A1 (en) 2008-02-12 2009-08-13 Nurith Kurn Method for Archiving and Clonal Expansion
CN102027367B (zh) 2008-02-29 2016-03-23 西北大学 促进生物反应的屏障
JP5198094B2 (ja) 2008-03-07 2013-05-15 シスメックス株式会社 分析装置
US7850917B2 (en) 2008-03-11 2010-12-14 Ortho-Clinical Diagnostics, Inc. Particle agglutination in a tip
JP5511095B2 (ja) 2008-03-20 2014-06-04 アバクシス， インコーポレイテッド ゾル粒子特異的結合アッセイの多波長分析
CN102047255B (zh) 2008-03-26 2016-08-03 赛拉诺斯股份有限公司 医疗信息系统
WO2009120372A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Compositions and methods for nucleic acid sequencing
WO2009123000A1 (ja) * 2008-03-31 2009-10-08 シスメックス株式会社 細胞処理装置、試料調製装置および細胞分析装置
CN102046809A (zh) 2008-04-05 2011-05-04 单细胞科技公司 筛选产生生物活性剂的单细胞的方法
EP2112514A1 (en) * 2008-04-24 2009-10-28 bioMérieux BV Method and apparatus for checking the fluid in a pipet tip
US20090274348A1 (en) 2008-04-30 2009-11-05 Ortho-Clinical Diagnostics, Inc. Immunodiagnostic test apparatus having at least one imager to provide agglutination evaluations during centrifugration cycle
US8029742B2 (en) 2008-05-05 2011-10-04 Integra Biosciences Corp. Multi-channel pipettor with repositionable tips
JP2010133924A (ja) * 2008-10-28 2010-06-17 Sysmex Corp 液体吸引機構および試料分析装置
EP2304436A1 (en) 2008-07-10 2011-04-06 Nodality, Inc. Methods for diagnosis, prognosis and treatment
EP2313767B1 (en) * 2008-07-16 2014-02-26 International Technidyne Corporation Cuvette-based apparatus for blood coagulation measurement and testing
US20100015690A1 (en) 2008-07-16 2010-01-21 Ortho-Clinical Diagnostics, Inc. Use of fluid aspiration/dispensing tip as a microcentrifuge tube
US9779213B2 (en) 2008-07-25 2017-10-03 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud System for evaluating a pathological stage of prostate cancer
EP2214011B1 (en) * 2008-08-01 2019-01-02 Sysmex Corporation Blood sample analyzing apparatus
US9034257B2 (en) 2008-10-27 2015-05-19 Nodality, Inc. High throughput flow cytometry system and method
GB2467704B (en) 2008-11-07 2011-08-24 Mlc Dx Inc A method for determining a profile of recombined DNA sequences in T-cells and/or B-cells
US8309306B2 (en) 2008-11-12 2012-11-13 Nodality, Inc. Detection composition
US8644547B2 (en) * 2008-11-14 2014-02-04 The Scripps Research Institute Image analysis platform for identifying artifacts in samples and laboratory consumables
US8900878B2 (en) 2008-11-28 2014-12-02 Roche Molecular Systems Inc. Pipetting device, modular pipetting unit, pipetting system and method for pipetting of fluid samples
JP2012511144A (ja) 2008-12-05 2012-05-17 エフ．ホフマン−ラ ロシュ アーゲー 試薬容器集合体の製造方法及び試薬容器集合体
JP2010145252A (ja) * 2008-12-18 2010-07-01 Nippon Soken Inc 液体燃料性状検出装置
WO2010069080A1 (en) 2008-12-19 2010-06-24 Stemcell Technologies Inc. Filter apparatus and filter plate system
DE202008017181U1 (de) * 2008-12-30 2009-03-26 Schmiedl, Dieter, Dr. Aliquotiereinrichtung
EP2389452A2 (en) 2009-01-21 2011-11-30 Vertex Pharmaceuticals Incorporated Methods for amplifying hepatitis c virus nucleic acids
JP2010175342A (ja) * 2009-01-28 2010-08-12 Hitachi High-Technologies Corp 自動分析装置及び反応容器
US20100215644A1 (en) 2009-02-25 2010-08-26 Nodality, Inc. A Delaware Corporation Analysis of nodes in cellular pathways
US20100246416A1 (en) 2009-03-25 2010-09-30 Amit Sinha Systems and methods for remote testing of wireless lan access points
US8320985B2 (en) 2009-04-02 2012-11-27 Empire Technology Development Llc Touch screen interfaces with pulse oximetry
US9080973B2 (en) 2009-04-22 2015-07-14 Wisconsin Alumni Research Foundation Analyte detection using liquid crystals
GB2473868A (en) 2009-09-28 2011-03-30 Invitrogen Dynal As Apparatus and method of automated processing of biological samples
EP2253958B1 (en) 2009-05-18 2013-04-17 F. Hoffmann-La Roche AG Centrifugal force based microfluidic system and method for the automated analysis of samples
JP2010281604A (ja) * 2009-06-02 2010-12-16 Aoi Seiki Kk 検体処理装置及び検体処理方法
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
CN102753977B (zh) 2009-07-27 2016-05-25 梅索磅秤技术有限公司 化验装置、耗材和方法
EP2311563A1 (en) 2009-08-07 2011-04-20 F. Hoffmann-La Roche AG Processing units and methods for the processing of liquid samples
US7982201B2 (en) * 2009-09-08 2011-07-19 Jadak, Llc System and method for detection of liquid level in a vessel
CN105740641A (zh) 2009-10-19 2016-07-06 提拉诺斯公司 集成的健康数据采集和分析系统
SG170703A1 (en) 2009-10-20 2011-05-30 Agency Science Tech & Res Microfluidic system for detecting a biological entity in a sample
EP2490814B1 (en) 2009-10-22 2015-01-14 Brian Page Pipette, apparatus and kit for light measurement and method
US9521055B2 (en) 2009-11-13 2016-12-13 Verizon Patent And Licensing Inc. Network connectivity management
US20120206587A1 (en) 2009-12-04 2012-08-16 Orscan Technologies Ltd System and method for scanning a human body
CA2994889C (en) 2009-12-07 2019-01-22 Meso Scale Technologies, Llc Assay cartridges and methods of using the same
US8748186B2 (en) 2009-12-22 2014-06-10 Abbott Laboratories Method for performing a blood count and determining the morphology of a blood smear
US9486803B2 (en) 2010-01-22 2016-11-08 Biotix, Inc. Pipette tips
EP2539719B1 (en) 2010-02-23 2019-12-25 Rheonix, Inc. Self-contained biological assay apparatus, methods, and applications
JP5564980B2 (ja) 2010-02-23 2014-08-06 日本電気株式会社 セキュリティスクリーニングシステムおよびセキュリティスクリーニング方法
US20110213579A1 (en) 2010-02-26 2011-09-01 Henke Tom L Method and apparatus for verifying test results
EP2539842A1 (en) 2010-02-26 2013-01-02 Quickcheck Health Inc. Method and apparatus for code verified testing
US20110213564A1 (en) 2010-02-26 2011-09-01 Henke Tom L Method and apparatus for code verified testing
US20110213619A1 (en) 2010-02-26 2011-09-01 Henke Tom L Method and system for online medical diagnosis
US20110218428A1 (en) 2010-03-04 2011-09-08 Medical Scan Technologies, Inc. System and Method for Three Dimensional Medical Imaging with Structured Light
US8588807B2 (en) 2010-04-28 2013-11-19 Palm, Inc. System and method for dynamically managing connections using a coverage database
BR112012031132B1 (pt) * 2010-06-07 2019-08-06 L'oreal Dispositivo para embalar e distribuir
EP2752668A3 (en) * 2010-07-23 2014-10-15 Beckman Coulter, Inc. System Or Method Of Including Analytical Units
US20120059664A1 (en) 2010-09-07 2012-03-08 Emil Markov Georgiev System and method for management of personal health and wellness
TW201219400A (en) 2010-09-24 2012-05-16 Array Biopharma Inc Compounds for treating neurodegenerative diseases
US8804114B2 (en) * 2010-11-03 2014-08-12 Pocared Diagnostics Ltd. Optical cup
EP2453233A1 (en) * 2010-11-16 2012-05-16 Roche Diagnostics GmbH Method and apparatus for detecting foam on a liquid surface in a vessel
JP6104810B2 (ja) 2010-11-23 2017-03-29 アンドリュー・アライアンス・ソシエテ・アノニムＡｎｄｒｅｗ Ａｌｌｉａｎｃｅ Ｓ．Ａ． ピペットのプログラミング可能な操作のための装置及び方法
WO2012075506A2 (en) 2010-12-03 2012-06-07 Beth Israel Deaconess Medical Center, Inc. Methods for predicting and treating infection-induced illnesses and predicting the severity of infection-induced illnesses
CN103282124B (zh) 2010-12-03 2016-05-18 雅培医护站股份有限公司 具有整合的样品稀释的样品计量装置和测定装置
WO2012094459A2 (en) 2011-01-06 2012-07-12 Glezer Eli N Assay cartridges and methods of using the same
CN106290159A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
EP2709762B1 (en) 2011-05-18 2021-03-31 DiaSorin S.p.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
US8809069B2 (en) 2011-05-20 2014-08-19 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
US20130039589A1 (en) * 2011-08-11 2013-02-14 I. R. I. S. Pattern recognition process, computer program product and mobile terminal
WO2013035875A1 (ja) 2011-09-08 2013-03-14 独立行政法人理化学研究所 プライマーセット及びそれを用いた標的核酸配列の増幅方法並びに変異核酸の検出方法
US20130074614A1 (en) 2011-09-25 2013-03-28 Theranos, Inc., a Delaware Corporation Container configurations
US20130080071A1 (en) 2011-09-25 2013-03-28 Theranos, Inc., a Delaware Corporation Systems and methods for sample processing and analysis
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
WO2013043203A2 (en) 2011-09-25 2013-03-28 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US20160320381A1 (en) 2011-09-25 2016-11-03 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
KR20140082756A (ko) 2011-09-25 2014-07-02 테라노스, 인코포레이티드 다중분석을 위한 시스템과 방법
US20140308661A1 (en) 2011-09-25 2014-10-16 Theranos, Inc. Systems and methods for multi-analysis
US20160077015A1 (en) 2011-09-25 2016-03-17 Theranos, Inc. Systems and methods for multi-analysis
US8392585B1 (en) 2011-09-26 2013-03-05 Theranos, Inc. Methods and systems for facilitating network connectivity
US20140335505A1 (en) 2011-09-25 2014-11-13 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US11249799B2 (en) 2011-09-26 2022-02-15 Labrador Diagnostics Llc Methods, systems, and devices for real time execution and optimization of concurrent test protocols on a single device
US20160069919A1 (en) 2011-09-25 2016-03-10 Theranos, Inc. Systems and methods for multi-analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
CN104066849B (zh) 2011-10-11 2017-04-19 凯杰有限公司 样品处理方法和样品处理盒
WO2013083822A1 (en) * 2011-12-08 2013-06-13 Biosurfit S.A. Sequential aliqoting and determination of an indicator of sedimentation rate
US9073052B2 (en) 2012-03-30 2015-07-07 Perkinelmer Health Sciences, Inc. Lab members and liquid handling systems and methods including same
US9389229B2 (en) 2012-07-18 2016-07-12 Theranos, Inc. Methods for detecting and measuring aggregation
SG11201500343VA (en) 2012-07-18 2015-02-27 Theranos Inc High speed, compact centrifuge for use with small sample volumes
KR20150055002A (ko) 2012-09-11 2015-05-20 테라노스, 인코포레이티드 생물학적 서명을 이용한 정보 관리 시스템 및 방법
US20140342371A1 (en) 2012-12-05 2014-11-20 Theranos, Inc. Bodily Fluid Sample Collection and Transport
US9051599B2 (en) 2012-12-10 2015-06-09 Theranos, Inc. Rapid, low-sample-volume cholesterol and triglyceride assays
US20140170678A1 (en) 2012-12-17 2014-06-19 Leukodx Ltd. Kits, compositions and methods for detecting a biological condition
US20160054343A1 (en) 2013-02-18 2016-02-25 Theranos, Inc. Systems and methods for multi-analysis
JP2016510418A (ja) 2013-02-18 2016-04-07 セラノス， インコーポレイテッド 多重分析のためのシステム及び方法
SG11201507273SA (en) 2013-03-15 2015-10-29 Theranos Inc Nucleic acid amplification
JP2016521120A (ja) 2013-03-15 2016-07-21 セラノス， インコーポレイテッド 核酸増幅
US9359632B2 (en) 2013-03-15 2016-06-07 Theranos, Inc. Devices, systems and methods for sample preparation
EP3674422A3 (en) 2013-09-06 2020-09-16 Labrador Diagnostics LLC Systems and methods for detecting infectious diseases
EP3042196A4 (en) 2013-09-06 2017-04-05 Theranos, Inc. Devices, systems, methods and kits for receiving a swab
TWI502067B (zh) 2013-12-10 2015-10-01 Nat Univ Tsing Hua 臨床檢體採樣器具及其方法
US10828636B2 (en) 2016-10-25 2020-11-10 Fannin Partners Llc Automated remotely instructed driving of an assay
DE102018007614B4 (de) 2018-09-25 2023-04-27 Otto-Von-Guericke-Universität Magdeburg Injektor und Verfahren zur Einspritzung von Kraftstoff und einer Zusatzflüssigkeit sowie Verwendung des Injektors

Also Published As

Publication number Publication date
NZ706352A (en) 2016-12-23
CN106323876A (zh) 2017-01-11
JP2018141798A (ja) 2018-09-13
AR085087A1 (es) 2013-09-11
JP2014504731A (ja) 2014-02-24
KR20140003553A (ko) 2014-01-09
ES2895518T3 (es) 2022-02-21
CA2825196C (en) 2021-01-05
CN103477197B (zh) 2016-08-17
CN106323876B (zh) 2020-02-14
TW201802245A (zh) 2018-01-16
US20160047834A1 (en) 2016-02-18
TWI639703B (zh) 2018-11-01
CN106290160A (zh) 2017-01-04
EP4024029A2 (en) 2022-07-06
SG192069A1 (en) 2013-08-30
US9464981B2 (en) 2016-10-11
EP2666008A2 (en) 2013-11-27
TWI690594B (zh) 2020-04-11
AU2012207090B2 (en) 2015-04-23
JP2016197106A (ja) 2016-11-24
BR112013018656B1 (pt) 2021-03-02
AU2012207090A1 (en) 2013-05-02
US9677993B2 (en) 2017-06-13
US20150185234A1 (en) 2015-07-02
BR112013018656A2 (pt) 2016-10-18
HK1232292A1 (zh) 2018-01-05
EP2666008A4 (en) 2015-06-03
US20160334403A1 (en) 2016-11-17
SG10201600463YA (en) 2016-02-26
CN106290159A (zh) 2017-01-04
CN106323875B (zh) 2019-07-09
WO2012100235A2 (en) 2012-07-26
CN106323875A (zh) 2017-01-11
WO2012100235A3 (en) 2012-10-18
EP2666008B1 (en) 2021-08-11
RU2620922C2 (ru) 2017-05-30
US11644410B2 (en) 2023-05-09
CA2825196A1 (en) 2012-07-26
US10557786B2 (en) 2020-02-11
CN111982829A (zh) 2020-11-24
MX349288B (es) 2017-07-21
CN103477197A (zh) 2013-12-25
US10876956B2 (en) 2020-12-29
JP5945282B2 (ja) 2016-07-05
CN106248582A (zh) 2016-12-21
US11199489B2 (en) 2021-12-14
TW201243056A (en) 2012-11-01
ZA201305478B (en) 2016-08-31
NZ613457A (en) 2015-04-24
US20170363536A1 (en) 2017-12-21
CN106248582B (zh) 2020-10-20
CA3097861A1 (en) 2012-07-26
US20210223163A1 (en) 2021-07-22
IL227579A0 (en) 2013-09-30
MX2013008339A (es) 2014-02-11
US20220252503A1 (en) 2022-08-11
US20120309636A1 (en) 2012-12-06
KR101909764B1 (ko) 2018-12-10
JP2021175982A (ja) 2021-11-04
JP6400630B2 (ja) 2018-10-03
TW202208825A (zh) 2022-03-01
EP4024029A3 (en) 2022-09-14
US20160006928A1 (en) 2016-01-07
IL227579B (en) 2019-05-30
TWI748368B (zh) 2021-12-01
TW202041677A (zh) 2020-11-16

Similar Documents

Publication Publication Date Title
RU2013137661A (ru) Системы и методы оптимизации использования образца
JP2014504731A5 (ru)
AU2010282784B2 (en) Methods and apparatus for ascertaining interferents and physical dimensions in liquid samples and containers to be analyzed by a clinical analyzer
US9915675B2 (en) Methods and apparatus for determining aspiration and/or dispensing volume and/or pipette positioning
JP2018141798A5 (ru)
JP5082010B2 (ja) 赤血球中に含まれるヘモグロビンの固有色素を利用して血液試料のヘマトクリットを測定する方法及び装置
KR101922718B1 (ko) 응집반응 결과 판정방법 및 응집반응물 판정용 마이크로플레이트
EP1186893A2 (en) Analyzer with sample quality measurement, and method
JP2007298445A (ja) 液面検知装置
JP5274436B2 (ja) 自動分析装置
JP6407895B2 (ja) 自動分析装置
US11125696B2 (en) Colorimetric analyzer with de-bubbling
JP2010190588A (ja) 自動分析装置
US11567097B2 (en) Apparatus for optically monitoring a dosing of a liquid to be pipetted
KR102360717B1 (ko) 반사형 포토센서를 이용한 전혈, 혈장 및 미흡입 자동구분방법
CN111337696B (zh) 一种体外诊断设备及其样本分析方法
CN110567900A (zh) 试样反应中抗原过量的判断方法、装置及光学检测系统
JP6929467B2 (ja) 液面検知装置
KR101181898B1 (ko) 평행이동 면역크로마토그래피를 이용한 생체물질의 정밀 분석 장치
CN105445231B (zh) 分析物的浊度测定方法
JP6895014B2 (ja) 便検体検査装置、便検体検査方法
JPH05307042A (ja) 自動血液分析装置

Legal Events

Date Code Title Description
PD4A Correction of name of patent owner
MM4A The patent is invalid due to non-payment of fees

Effective date: 20210121