ATE521718T1 - Prozess zur synthetisierung von nukleinsäure - Google Patents

Prozess zur synthetisierung von nukleinsäure

Info

Publication number
ATE521718T1
ATE521718T1 AT09000525T AT09000525T ATE521718T1 AT E521718 T1 ATE521718 T1 AT E521718T1 AT 09000525 T AT09000525 T AT 09000525T AT 09000525 T AT09000525 T AT 09000525T AT E521718 T1 ATE521718 T1 AT E521718T1
Authority
AT
Austria
Prior art keywords
nucleic acid
primer
synthesizing
synthesizing nucleic
oligonucleotide
Prior art date
Application number
AT09000525T
Other languages
English (en)
Inventor
Tsugunori Notomi
Tetsu Hase
Original Assignee
Eiken Chemical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18088663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE521718(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eiken Chemical filed Critical Eiken Chemical
Application granted granted Critical
Publication of ATE521718T1 publication Critical patent/ATE521718T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/125—Specific component of sample, medium or buffer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/119—Strand displacement amplification [SDA]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT09000525T 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsäure ATE521718T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31747698 1998-11-09

Publications (1)

Publication Number Publication Date
ATE521718T1 true ATE521718T1 (de) 2011-09-15

Family

ID=18088663

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99954435T ATE374833T1 (de) 1998-11-09 1999-11-08 Verfahren zur synthese von nukleinsäuren
AT07014809T ATE426045T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsaure
AT09000525T ATE521718T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsäure

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT99954435T ATE374833T1 (de) 1998-11-09 1999-11-08 Verfahren zur synthese von nukleinsäuren
AT07014809T ATE426045T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsaure

Country Status (9)

Country Link
US (5) US6410278B1 (de)
EP (4) EP1873260B1 (de)
JP (2) JP3313358B2 (de)
AT (3) ATE374833T1 (de)
DE (3) DE1020534T1 (de)
ES (4) ES2393056T3 (de)
HK (3) HK1029378A1 (de)
MY (3) MY137889A (de)
WO (1) WO2000028082A1 (de)

Families Citing this family (388)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US8445664B2 (en) * 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
EP1873260B1 (de) * 1998-11-09 2009-03-18 Eiken Kagaku Kabushiki Kaisha Prozess zur Synthetisierung von Nukleinsäure
BR0014182A (pt) 1999-09-13 2002-05-21 Nugen Technologies Inc Processos e composições para amplificação isotérmica linear de sequências polinucleotìdicas
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
AU1057801A (en) * 1999-11-08 2001-06-06 Eiken Kagaku Kabushiki Kaisha Method of detecting variation or polymorphism
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
WO2001077317A1 (en) * 2000-04-07 2001-10-18 Eiken Kagaku Kabushiki Kaisha Method of amplifying nucleic acid by using double-stranded nucleic acid as template
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ES2390242T3 (es) 2000-09-19 2012-11-07 Eiken Kagaku Kabushiki Kaisha Procedimiento para sintetizar polinucleótidos
JPWO2002034907A1 (ja) * 2000-10-27 2004-03-04 栄研化学株式会社 １本鎖核酸の合成方法
JP2002171999A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
JP2002171998A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
JP2002171997A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
CA2430329A1 (en) * 2000-12-13 2002-06-20 Nugen Technologies, Inc. Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof
JP2002186481A (ja) * 2000-12-18 2002-07-02 Eiken Chem Co Ltd 光学的特性の測定による核酸増幅産物の検出方法
KR20030071854A (ko) * 2001-02-06 2003-09-06 다카라 바이오 가부시키가이샤 증폭 핵산 및 그의 고정화물
ATE361996T1 (de) * 2001-03-09 2007-06-15 Nugen Technologies Inc Methoden und zusammensetzungen zur vervielfältigung von rna sequenzen
JP2002272475A (ja) * 2001-03-22 2002-09-24 Eiken Chem Co Ltd 蛍光偏光法による核酸増幅産物の検出方法
WO2002090538A1 (fr) * 2001-05-08 2002-11-14 Eiken Kagaku Kabushiki Kaisha Procede de synthese d'acide nucleique
US8137911B2 (en) 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
US7838270B2 (en) 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
JP2002345499A (ja) * 2001-05-29 2002-12-03 Eiken Chem Co Ltd 核酸配列を検出する方法及びその方法に使用するキット
JPWO2002101042A1 (ja) * 2001-06-12 2005-04-07 タカラバイオ株式会社 核酸増幅又は検出反応用試薬の安定化方法ならびに保存方法
JP2005052002A (ja) * 2001-07-06 2005-03-03 Wakunaga Pharmaceut Co Ltd 非環状核酸断片の増幅方法
KR20040028991A (ko) 2001-08-20 2004-04-03 다카라 바이오 가부시키가이샤 핵산 증폭 방법
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
ATE425263T1 (de) 2001-11-19 2009-03-15 Parallele Bioscience Inc Multiplex-oligonukleotidaddition und zielamplifikation
ATE554164T1 (de) 2002-02-20 2012-05-15 Sysmex Corp Primer für nukleinsäureamplifikation bei der detektion von haushaltsgen-mrna und testverfahren unter verwendung der primer
WO2003097878A1 (fr) 2002-05-21 2003-11-27 Sysmex Corporation Amorces d'amplification d'acide nucleique destinees a detecter des cytokeratines et technique d'examen utilisant ces amorces
GB0218215D0 (en) * 2002-08-06 2002-09-11 Tepnel Medical Ltd Amplification of nucleic acids
WO2004016755A2 (en) * 2002-08-16 2004-02-26 Geneohm Sciences Amplification of target nucleotide sequence without polymerase chain reaction
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
JP4560285B2 (ja) * 2002-10-02 2010-10-13 栄研化学株式会社 核酸沈澱剤を利用した核酸増幅産物のハイブリダイゼーションアッセイ
WO2004040019A1 (ja) * 2002-10-29 2004-05-13 Riken 核酸の増幅法
JP2004154088A (ja) * 2002-11-08 2004-06-03 Sysmex Corp Ｃｅａ検出のための核酸増幅用プライマーおよび該プライマーを用いた検査方法
EP1567675A4 (de) 2002-11-21 2006-05-10 Epict Technologies Verfahren zur verwendung von primern,die für einen strang eines doppelsträngigen promotors codieren
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
US7851150B2 (en) 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
JP4280519B2 (ja) * 2003-03-07 2009-06-17 アークレイ株式会社 Ｄｎａ増幅法およびそのためのキット
CA2521084A1 (en) 2003-04-14 2004-10-28 Nugen Technologies, Inc. Global amplification using a randomly primed composite primer
EP1633893B1 (de) 2003-05-19 2012-01-25 Gen-Probe Incorporated Zusammensetzungen, verfahren und kits zur bestimmung des vorhandenseins von trichomonas vaginalis in einer testprobe
CN1813064B (zh) * 2003-06-27 2011-11-02 荣研化学株式会社 检测sars冠状病毒的方法
EP1710587B1 (de) * 2003-08-20 2016-08-03 Sysmex Corporation Nukleinsäuredetekionsverfahren
US20050042145A1 (en) * 2003-08-22 2005-02-24 Sysmex Corporation Container for analyzer, detection container, reaction container and packing container for storing detection container
KR100968901B1 (ko) 2003-12-10 2010-07-14 다카라 바이오 가부시키가이샤 핵산의 증폭방법
TW200525026A (en) 2003-12-25 2005-08-01 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
JP4542345B2 (ja) * 2004-01-15 2010-09-15 シスメックス株式会社 分析装置
JP4505230B2 (ja) * 2004-01-20 2010-07-21 シスメックス株式会社 分析装置
JP4632670B2 (ja) * 2004-01-21 2011-02-16 シスメックス株式会社 濁度検出用光学装置及びそれを用いた濁度検出装置
JP4320266B2 (ja) * 2004-01-22 2009-08-26 シスメックス株式会社 分注装置およびそれを備えた分析装置
US20050164375A1 (en) * 2004-01-23 2005-07-28 Sysmex Corporation Nucleic acid detection apparatus
CA2558266C (en) 2004-03-05 2017-10-17 Gen-Probe Incorporated Reagents, methods and kits for use in deactivating nucleic acids
WO2005093059A1 (ja) * 2004-03-25 2005-10-06 Sapporo Breweries Limited 酵母、乳酸菌及び偏性嫌気性菌検出・識別のためのプライマー及びプライマーセット並びにそれらを用いた検出・識別方法
WO2005113816A2 (en) 2004-05-07 2005-12-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer
US20090226892A1 (en) 2004-08-31 2009-09-10 Eiken Kagaku Kabushiki Kaisha Nucleic acid analysis method
JP2008000002A (ja) * 2004-09-30 2008-01-10 Sysmex Corp リブロース２リン酸カルボキシラーゼスモールチェーン１Ａ（ＲＢＣＳ−１Ａ）遺伝子及び／又は該遺伝子のｍＲＮＡを検出するための核酸増幅用プライマ、及び内部標準として該遺伝子及び／又は該遺伝子のｍＲＮＡを用いた検査方法。
JP5019431B2 (ja) * 2004-10-19 2012-09-05 学校法人日本大学 インフルエンザ菌の検出方法、インフルエンザ菌検出用プライマーセット及びインフルエンザ菌検出用キット
WO2006049061A1 (ja) 2004-11-01 2006-05-11 Eiken Kagaku Kabushiki Kaisha Ｈ５型又はｈ７型トリインフルエンザウイルスの検出方法
JP5160725B2 (ja) * 2004-11-02 2013-03-13 シスメックス株式会社 チップラックおよびチップ組立品
US20080305142A1 (en) * 2004-12-11 2008-12-11 Cytogenix, Inc. Cell Free Biosynthesis of High-Quality Nucleic Acid and Uses Thereof
EP2333561A3 (de) 2005-03-10 2014-06-11 Gen-Probe Incorporated System zum Durchführen von Tests in mehreren Formaten
EP2348320B1 (de) 2005-03-10 2024-05-01 Gen-Probe Incorporated Verfahren und Systeme zur Erkennung mehrerer Fluoreszenzemissionssignale
FR2885140B1 (fr) 2005-04-29 2010-12-31 Millipore Corp Procede de detection et de caracterisation de microorgarnismes sur une membrane.
JP2008544214A (ja) 2005-05-09 2008-12-04 セラノス， インコーポレイテッド ポイントオブケア流体システムおよびその使用
WO2006123423A1 (ja) * 2005-05-20 2006-11-23 Sapporo Breweries Limited フザリウム属菌検出用プライマー
JP4733456B2 (ja) * 2005-07-26 2011-07-27 シスメックス株式会社 前処理の外部精度管理方法、核酸検出処理の外部精度管理方法、検量線作成処理の外部精度管理方法、前処理の外部精度管理コンピュータ、核酸検出処理の外部精度管理コンピュータ、検量線作成処理の外部精度管理コンピュータ、前処理装置、及び核酸検出装置
WO2007018257A1 (ja) 2005-08-10 2007-02-15 Hamamatsu Foundation For Science And Technology Promotion 大腸癌マーカー検出方法
JP2007043997A (ja) * 2005-08-11 2007-02-22 Tosoh Corp 新規な標的核酸の増幅キット
US20100203505A1 (en) 2005-08-18 2010-08-12 Eisai R&D Management Co., Ltd. DOPAMINERGIC NEURON PROLIFERATIVE PROGENITOR CELL MARKER Msx1/2
ATE550441T1 (de) * 2005-09-06 2012-04-15 Gen Probe Inc Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren
WO2007030759A2 (en) 2005-09-07 2007-03-15 Nugen Technologies, Inc. Improved nucleic acid amplification procedure
US8831887B2 (en) * 2005-10-12 2014-09-09 The Research Foundation For The State University Of New York Absolute PCR quantification
US7910719B2 (en) * 2005-12-08 2011-03-22 Kabushiki Kaisha Toshiba Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier
JP4989493B2 (ja) * 2006-01-20 2012-08-01 オリンパス株式会社 分子内プローブによる核酸配列の検出方法
JP4516032B2 (ja) * 2006-01-20 2010-08-04 株式会社東芝 ハイブリダイゼーションによる核酸の検出方法およびアッセイキット
JP4580875B2 (ja) 2006-01-20 2010-11-17 株式会社東芝 核酸検出法のためのプライマーの設計方法
JP4881623B2 (ja) * 2006-01-27 2012-02-22 シスメックス株式会社 Ｃｅａ核酸増幅用プライマー、プライマーセット、及びがんの診断支援方法
US7488581B2 (en) 2006-03-20 2009-02-10 Kabushiki Kaisha Toshiba Method for detecting a target nucleic acid sequence
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
EP2006382B1 (de) 2006-04-11 2016-08-03 Eisai R&D Management Co., Ltd. Dopamin produzierender neuronenvorläuferzellmarker 187a5
JPWO2007123265A1 (ja) * 2006-04-19 2009-09-10 学校法人日本大学 各有莢膜型インフルエンザ菌の検出方法、検出用プライマーセット、及び検出用キット
AU2007244658B2 (en) 2006-04-28 2014-02-13 Igor Kutyavin Use of base-modified deoxynucleoside triphosphates
EP2021506B1 (de) * 2006-04-28 2016-03-16 Igor Kutyavin Verwendung von pcr-amplifikationsprodukten mit elementen sekundärer struktur für verbesserten pcr-basierten nukleinsäurenachweis
RU2404255C2 (ru) 2006-05-16 2010-11-20 Кирин Бир Кабусики Кайся Набор праймеров для использования при детекции дрожжей рода dekkera и дрожжей рода brettanomyces
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
ATE536424T1 (de) 2006-06-06 2011-12-15 Gen Probe Inc Markierte oligonukleotide und ihre verwendung in nukleinsäureverstärkungsverfahren
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
JP2009545316A (ja) * 2006-07-31 2009-12-24 ワンリ ビ 可逆的に修飾されたオリゴヌクレオチドを使用する核酸増幅
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
AU2007284651B2 (en) 2006-08-09 2014-03-20 Institute For Systems Biology Organ-specific proteins and methods of their use
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
US7939299B2 (en) 2006-08-31 2011-05-10 Toyo Seikan Kaisha, Ltd. Nucleic acid amplification method
EP2079754B1 (de) * 2006-10-04 2017-03-15 Third Wave Technologies, Inc. Snap-back primer und nachweisbare hairpin-strukturen
WO2008044358A1 (fr) * 2006-10-05 2008-04-17 Kirin Beer Kabushiki Kaisha Ensemble d'amorces destiné à la détection d'une levure saccharomyces
US8338109B2 (en) 2006-11-02 2012-12-25 Mayo Foundation For Medical Education And Research Predicting cancer outcome
JP2008136389A (ja) * 2006-11-30 2008-06-19 Sapporo Breweries Ltd アップルモザイクウイルスの検出方法、検出用プライマーセット及び検出用キット
JP2008136386A (ja) * 2006-11-30 2008-06-19 Sapporo Breweries Ltd ホップ潜在ウイルスの検出方法、検出用プライマーセット及び検出用キット
JP2008194028A (ja) 2007-01-15 2008-08-28 Sysmex Corp 胃がんのリンパ節転移判定方法
AU2008206221A1 (en) 2007-01-17 2008-07-24 Meridian Bioscience, Inc. Stable reagents and kits useful in loop-mediated isothermal amplification (LAMP)
JP4331216B2 (ja) 2007-02-09 2009-09-16 株式会社東芝 遺伝子変異の検出方法
JP2008212009A (ja) 2007-02-28 2008-09-18 Sysmex Corp Ｄｎａメチル化検出用試料の調製方法
JPWO2008111466A1 (ja) 2007-03-05 2010-06-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 遺伝子の発現量減少を指標とする抗ガン剤の作用検定方法
WO2008111464A1 (ja) 2007-03-05 2008-09-18 Eisai R & D Management Co., Ltd. スプライシング異常を指標とする抗ガン剤の作用検定方法
CA2622649C (en) 2007-03-09 2018-04-24 Riken Nucleic acid amplification method using primer exhibiting exciton effect
US8153064B2 (en) 2007-03-22 2012-04-10 Doebler Ii Robert W Systems and devices for isothermal biochemical reactions and/or analysis
JP4410268B2 (ja) * 2007-03-28 2010-02-03 株式会社東芝 メチレンテトラヒドロ葉酸還元酵素（ｍｔｈｆｒ）の遺伝子型を検出するための核酸プライマーセット及び核酸プローブ
JP4410269B2 (ja) 2007-03-28 2010-02-03 株式会社東芝 Ｎ−アセチルトランスフェラーゼ２（ｎａｔ２）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法
JP4490988B2 (ja) * 2007-04-26 2010-06-30 株式会社東芝 血清アミロイドａ１（ｓａａ１）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法
ES2542407T3 (es) 2007-05-28 2015-08-05 Ehime University Cebadores para detectar Plasmodium
EP2465609B1 (de) 2007-06-21 2016-12-28 Gen-Probe Incorporated Verfahren zum Mischen der Inhalte einer Nachweiskammer
JP2009000044A (ja) * 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
JP4551917B2 (ja) * 2007-07-18 2010-09-29 株式会社東芝 ヒトチトクロームｐ４５０（ｃｙｐ）２ｄ６遺伝子変異の検出方法
US8143006B2 (en) * 2007-08-03 2012-03-27 Igor Kutyavin Accelerated cascade amplification (ACA) of nucleic acids comprising strand and sequence specific DNA nicking
CA3138078C (en) 2007-10-02 2024-02-13 Labrador Diagnostics Llc Modular point-of-care devices and uses thereof
US20100221787A1 (en) 2007-10-25 2010-09-02 Riken Isothermal amplification method and dna polymerase used in the same
EP2058406A3 (de) * 2007-11-06 2009-10-28 Fujifilm Corporation RNA-Detektionsverfahren
EP2232259B1 (de) 2008-01-09 2016-10-12 Keck Graduate Institute System, vorrichtung und verfahren zur materialvorbereitung und/oder -handhabung
US8034568B2 (en) * 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090215050A1 (en) * 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
WO2009117698A2 (en) 2008-03-21 2009-09-24 Nugen Technologies, Inc. Methods of rna amplification in the presence of dna
US20110053168A1 (en) * 2008-03-28 2011-03-03 Sysmex Corporation REAGENT COMPRISING PRIMER FOR DETECTION OF mRNA FOR CYTOKERATIN-7
WO2009140374A2 (en) 2008-05-13 2009-11-19 Gen-Probe Incorporated Inactivatable target capture oligomers for use in the selective hybridization and capture of target nucleic acid sequences
EP2806054A1 (de) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systeme und Verfahren zur expressionsbasierten Unterscheidung verschiedener klinischer Krankheitszustände bei Prostatakrebs
WO2009145279A1 (ja) 2008-05-28 2009-12-03 花王株式会社 耐熱性菌類の検出方法
US9102987B2 (en) 2008-05-29 2015-08-11 Kao Corporation Method of detecting paecilomyces variotii
EP2298885A4 (de) * 2008-05-29 2012-12-19 Sysmex Corp Primer zum nachweis von tyrosinase-mrna
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
JP5383105B2 (ja) * 2008-06-30 2014-01-08 キユーピー株式会社 オリゴヌクレオチド及びこれをプライマーとして用いたバチルス・コアグランスの検出法
WO2010030716A1 (en) * 2008-09-10 2010-03-18 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
WO2010048605A1 (en) 2008-10-24 2010-04-29 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
US9080211B2 (en) * 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
EP2371951A4 (de) 2008-11-27 2012-07-18 Riken NEUARTIGES MutS-PROTEIN UND SEINE VERWENDUNG ZUR BESTIMMUNG VON MUTATIONEN
KR101805927B1 (ko) 2008-12-25 2017-12-06 유니바사루 바이오 리사치 가부시키가이샤 검체의 전처리 방법, 및 생체 관련 물질의 측정 방법
AU2010208386B2 (en) * 2009-01-27 2016-08-11 Qiagen Gaithersburg Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
US8368882B2 (en) 2009-01-30 2013-02-05 Gen-Probe Incorporated Systems and methods for detecting a signal and applying thermal energy to a signal transmission element
US8409805B2 (en) * 2009-02-13 2013-04-02 Asuragen, Inc. Method of amplification of GC-rich DNA templates
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
EP2411532B1 (de) 2009-03-24 2017-04-05 Asuragen, Inc. Pcr-verfahren zur charakterisierung des 5 -nichttranslatierten bereichs der gene fmr1 und fmr2
WO2010129934A2 (en) 2009-05-07 2010-11-11 Veracyte, Inc. Methods and compositions for diagnosis of thyroid conditions
JP5711227B2 (ja) 2009-06-26 2015-04-30 クレアモント バイオソリューソンズ エルエルシー 試料破壊用ビーズを利用した生物検体の捕捉および溶出
EP2272980A1 (de) * 2009-07-09 2011-01-12 Bioesplora SRL Molekulare Sonden zum Nachweis und zur Quantifizierung von Target-Nukleinsäure
EP2272978B1 (de) 2009-07-10 2012-04-18 Biotrin International Limited Hochsensibles schnelles isothermisches Verfahren zur Detektion von Punktmutationen und SNPs
WO2011007889A1 (ja) 2009-07-17 2011-01-20 東洋製罐株式会社 核酸の増幅方法
EP2287335A1 (de) 2009-08-05 2011-02-23 DiaSorin S.p.A. Hoch empfindliches schnelles isothermisches Verfahren zur Erkennung von Methylierungsstrukturen
US8598327B2 (en) 2009-08-18 2013-12-03 Baxter International Inc. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
SG178408A1 (en) * 2009-08-18 2012-03-29 Baxter Int Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
JP6057460B2 (ja) 2009-08-31 2017-01-11 ジェン−プローブ・インコーポレーテッド デングウイルスアッセイ
WO2011037802A2 (en) 2009-09-28 2011-03-31 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
EP2531515B1 (de) 2010-01-22 2015-10-21 Gen-Probe Incorporated Sonden zur erkennung des vorhandenseins von trichomonas vaginalis in einer probe
JP2012000031A (ja) 2010-06-15 2012-01-05 Sysmex Corp 肺がんのリンパ節転移の検査方法、肺がんのリンパ節転移判定装置およびコンピュータプログラム
AU2011272868B2 (en) 2010-06-30 2015-09-17 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
WO2012029993A1 (en) 2010-09-02 2012-03-08 Riken Method of detecting type ii diabetes
CA3155334A1 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. NMR SYSTEMS AND METHODS FOR RAPID ANALYTE DETECTION
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012061283A1 (en) 2010-11-04 2012-05-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rapid molecular assays for specific detection and quantitation of loa loa microfilaremia
TWI435935B (zh) * 2010-12-06 2014-05-01 Univ Nat Cheng Kung 快速檢測標靶核酸片段之套組及方法
US9845495B2 (en) 2010-12-10 2017-12-19 Abbott Laboratories Method and kit for detecting target nucleic acid
CN106290160A (zh) 2011-01-21 2017-01-04 提拉诺斯公司 样品使用最大化的系统和方法
ES2617599T3 (es) 2011-04-15 2017-06-19 Becton, Dickinson And Company Termociclador microfluídico de exploración en tiempo real y métodos para termociclado sincronizado y detección óptica de exploración
US9518901B2 (en) 2011-06-29 2016-12-13 Kabushiki Kaisha Dnaform Pretreatment method of biological sample, detection method of RNA, and pretreatment kit
GB201112140D0 (en) 2011-07-14 2011-08-31 Dna Electronics Nucleic acid amplification
US9586987B2 (en) 2011-09-08 2017-03-07 Kabushiki Kaisha Dnaform Primer set for isothermal amplication of a target nucleic acid sequence
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US9175337B2 (en) 2011-09-21 2015-11-03 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
RU2627927C2 (ru) 2011-09-25 2017-08-14 Теранос, Инк. Системы и способы многостороннего анализа
CA2857308C (en) 2011-10-31 2019-10-01 Eiken Kagaku Kabushiki Kaisha Method for detecting target nucleic acid
US20140295415A1 (en) * 2011-11-04 2014-10-02 Diagnostics For All, Inc. Low cost, disposable molecular diagnostic devices
US10513737B2 (en) 2011-12-13 2019-12-24 Decipher Biosciences, Inc. Cancer diagnostics using non-coding transcripts
WO2013129542A1 (ja) 2012-02-29 2013-09-06 独立行政法人理化学研究所 Ｈｌａ－ａ＊３１：０１アレルの検出方法
CA2869033C (en) 2012-03-29 2021-06-01 Becton, Dickinson And Company Nucleic acids for nucleic acid amplification
CA2869717C (en) 2012-04-13 2022-09-06 Becton, Dickinson And Company Reflex testing of samples using residual materials from a prior test
EP2876160B1 (de) 2012-07-06 2020-05-13 Kyoto Prefectural Public University Corporation Differenzierungsmarker und differenzierungskontrolle für augenzellen
US20140038182A1 (en) * 2012-07-17 2014-02-06 Dna Logix, Inc. Cooperative primers, probes, and applications thereof
ES2759023T3 (es) 2012-07-20 2020-05-07 Asuragen Inc Genotipificación completa de FMR1
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
DK3435084T3 (da) 2012-08-16 2023-05-30 Mayo Found Medical Education & Res Prostatakræftprognose under anvendelse af biomarkører
US20140081665A1 (en) 2012-09-11 2014-03-20 Theranos, Inc. Information management systems and methods using a biological signature
JP2015536672A (ja) 2012-11-28 2015-12-24 エービーウィズ バイオ，インク． 単一プライマー増幅における使用のための遺伝子特異的なテンプレートの調製
JP6200281B2 (ja) 2012-11-29 2017-09-20 シスメックス株式会社 甲状腺腫瘍の性状の判別を補助する方法およびその方法に用いるマーカーセット
MX354033B (es) 2013-02-18 2018-02-09 Theranos Ip Co Llc Sistemas y métodos para recolectar y transmitir resultados de ensayos.
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
US9789483B2 (en) 2013-03-11 2017-10-17 Cue Inc. System for portable and easy-to-use detection of analytes with mobile computing device
AU2013202788B2 (en) 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
AU2013202778A1 (en) 2013-03-14 2014-10-02 Gen-Probe Incorporated Systems, methods, and apparatuses for performing automated reagent-based assays
ES2671745T3 (es) 2013-03-15 2018-06-08 Becton, Dickinson And Company Detección de Neisseria gonorrhoeae
US11976329B2 (en) 2013-03-15 2024-05-07 Veracyte, Inc. Methods and systems for detecting usual interstitial pneumonia
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
ES2881080T3 (es) 2013-03-15 2021-11-26 Labrador Diagnostics Llc Amplificación de ácidos nucleicos
WO2014145269A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Thermostable blunt-end ligase and methods of use
AU2014233152A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
US9677981B2 (en) 2013-03-15 2017-06-13 3M Innovative Properties Company Sample concentrator and method of use
CA2906484A1 (en) 2013-03-15 2014-09-25 Theranos, Inc. Devices, systems and methods for sample preparation
ES2738602T3 (es) 2013-03-15 2020-01-24 Theranos Ip Co Llc Amplificación de ácidos nucleicos
EP3012326A4 (de) 2013-03-26 2016-12-21 Nippon Gene Co Ltd Primer und sondenset zur identifizierung von genpolymorphismus und verwendung davon
JP5951545B2 (ja) 2013-03-29 2016-07-13 シスメックス株式会社 検体分析装置、検体分析方法、及びコンピュータプログラム
US20160138013A1 (en) 2013-05-30 2016-05-19 The Regents Of The University Of California Substantially unbiased amplification of genomes
CN103276083B (zh) * 2013-05-30 2014-11-19 首都医科大学附属北京友谊医院 肺炎支原体检测试剂盒
WO2015013465A2 (en) 2013-07-25 2015-01-29 Dch Molecular Diagnostics, Inc. Methods and compositions for detecting bacterial contamination
EP3029140A4 (de) 2013-07-30 2017-06-28 Kyoto Prefectural Public University Corporation Hornhautendothel-zellmarker
KR102398399B1 (ko) 2013-08-09 2022-05-16 루미넥스 코포레이션 핵산 에세이에서의 향상된 용융 식별 및 복합화를 위한 프로브
WO2015019247A1 (en) * 2013-08-09 2015-02-12 Genebio Systems, Inc. Dna amplification via scissor-like structures (dasl)
KR20160053979A (ko) 2013-09-06 2016-05-13 테라노스, 인코포레이티드 전염성 질환의 검출을 위한 시스템 및 방법
JP6118223B2 (ja) 2013-09-27 2017-04-19 シスメックス株式会社 液体吸引装置、検体分析装置、およびチップ収容容器
JP6339787B2 (ja) * 2013-10-09 2018-06-06 株式会社日立ハイテクノロジーズ 核酸の分析方法
US10196684B2 (en) 2013-10-18 2019-02-05 California Institute Of Technology Enhanced nucleic acid identification and detection
EP3063272A2 (de) 2013-10-30 2016-09-07 Green Life Biotech, LLC Pathogenesequantifizierungssysteme und behandlungsverfahren für mehltau von zitrusgewächsen
JP2015087329A (ja) 2013-10-31 2015-05-07 シスメックス株式会社 吸引部の位置調整方法及び検体処理装置
EP3628747B1 (de) 2013-12-05 2022-10-05 Centrillion Technology Holdings Corporation Herstellung von gemusterten anordnungen
CN107002117B (zh) 2013-12-05 2021-12-10 生捷科技控股公司 核酸测序方法
EP3077430A4 (de) 2013-12-05 2017-08-16 Centrillion Technology Holdings Corporation Modifizierte oberfläche
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
US10767222B2 (en) 2013-12-11 2020-09-08 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
ES2754251T3 (es) 2014-01-15 2020-04-16 Abbott Lab Secuencia cubierta de conversión de ADN y métodos de detección
CN103789436B (zh) * 2014-01-30 2015-09-30 思博奥科生物信息科技（北京）有限公司 一种基于人工修饰引物的定量突变检测系统
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
WO2015152024A1 (ja) 2014-03-31 2015-10-08 独立行政法人理化学研究所 蛍光性標識一本鎖核酸及びその用途
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015183837A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
WO2015183836A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
WO2015187849A2 (en) 2014-06-04 2015-12-10 Lucigen Corporation Sample collection and analysis devices
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
EP3169793B1 (de) 2014-07-16 2022-07-06 Tangen Biosciences Inc. Isothermische verfahren zur amplifizierung von nukleinsäureproben
JP6664381B2 (ja) 2014-08-11 2020-03-13 ルミネックス コーポレーション 核酸アッセイにおける改善された融解識別と多重化のためのプローブ
WO2016059473A2 (en) 2014-10-14 2016-04-21 Abbott Japan Co., Ltd Sequence conversion and signal amplifier dna having locked nucleic acids and detection methods using same
JP6491458B2 (ja) 2014-10-31 2019-03-27 シスメックス株式会社 核酸増幅方法
US11559801B2 (en) 2014-11-03 2023-01-24 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
EP3770274A1 (de) 2014-11-05 2021-01-27 Veracyte, Inc. Systeme und verfahren zur diagnose von idiopathischer pulmonaler fibrose auf transbronchialen biopsien mit maschinellem lernen und hochdimensionalen transkriptionsdaten
EP3218513B1 (de) 2014-11-11 2018-10-31 Illumina, Inc. Polynukleotidamplifikation mit crispr-cas-systemen
CN108064312B (zh) 2014-12-24 2022-04-08 雅培实验室 基于具有靶扩增的信号放大dna级联反应的检测方法
US11326213B2 (en) 2015-01-21 2022-05-10 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of tick-borne pathogens
US10724091B1 (en) 2015-02-10 2020-07-28 National Technology & Engineering Solutions Of Sandia, Llc Endpoint detection of amplified nucleic acids
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
JP6518110B2 (ja) * 2015-03-31 2019-05-22 株式会社カネカ クレブシエラ・ニューモニエ（Ｋｌｅｂｓｉｅｌｌａｐｎｅｕｍｏｎｉａｅ）を検出するためのプライマー及び方法
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
EP4435119A2 (de) 2015-04-24 2024-09-25 Becton, Dickinson and Company Multiplex-nachweis von vulvovaginaler candidose, trichomoniasis und bakterieller vaginose
CA2983819A1 (en) 2015-04-24 2016-10-27 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
CN107636164B (zh) 2015-05-29 2022-02-18 豪夫迈·罗氏有限公司 用柠康酸酐灭活微生物的方法
US10260090B2 (en) 2015-07-16 2019-04-16 Arizona Board Of Regents On Behalf Of Arizona State University Accelerated isothermal amplification of DNA
BR112018000851B1 (pt) 2015-07-17 2022-10-18 Cue Health Inc Cartucho de análise de amostras, placas de circuito para o mesmo e método de amplificação
CA2992616C (en) 2015-07-23 2023-01-03 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating a/t-rich segments
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
CN114807323A (zh) 2015-10-09 2022-07-29 安可济控股有限公司 用于富集扩增产物的方法及组合物
CN108699505A (zh) 2015-12-03 2018-10-23 安可济控股有限公司 用于形成连接产物的方法和组合物
WO2017127727A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
EP3416658B1 (de) 2016-02-15 2023-03-22 Kyoto Prefectural Public University Corporation Menschliche funktionelle hornhautendothelzelle und anwendung davon
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
WO2017173342A1 (en) 2016-03-31 2017-10-05 William Beaumont Hospital Methods for detecting, diagnosing and treating ulcerative interstitial cystitis
AU2017250205A1 (en) 2016-04-14 2018-11-22 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
EP4269611A3 (de) 2016-05-11 2024-01-17 Illumina, Inc. Polynukleotidanreicherung und -amplifikation unter verwendung von argonautensystemen
EP3458586B1 (de) 2016-05-16 2022-12-28 Accuragen Holdings Limited Verfahren zur verbesserten sequenzierung durch strangidentifizierung
WO2017212904A1 (ja) * 2016-06-06 2017-12-14 国立大学法人 宮崎大学 複数のプライマーセットを組み合わせたｌａｍｐ法を用いたアフリカ豚コレラウイルスの迅速検出法
WO2018035170A1 (en) 2016-08-15 2018-02-22 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
EP3504348B1 (de) 2016-08-24 2022-12-14 Decipher Biosciences, Inc. Verwendung von genomischen signaturen zur vorhersage des ansprechens von patienten mit prostatakrebs auf postoperative strahlentherapie
US11578358B2 (en) 2016-09-15 2023-02-14 Abbott Laboratories Devices and methods for sample analysis
US10724089B2 (en) 2016-10-06 2020-07-28 The Board Of Trustees Of The University Of Illinois Spatial molecular analysis of tissue
EP4095263A1 (de) 2017-01-06 2022-11-30 Editas Medicine, Inc. Verfahren zur beurteilung der nukleasespaltung
US11208697B2 (en) 2017-01-20 2021-12-28 Decipher Biosciences, Inc. Molecular subtyping, prognosis, and treatment of bladder cancer
US11237161B2 (en) 2017-01-25 2022-02-01 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
US11873532B2 (en) 2017-03-09 2024-01-16 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
JP6924600B2 (ja) 2017-04-10 2021-08-25 シスメックス株式会社 測定方法、測定装置、プログラム、演算式の取得方法および定性判定結果の表示方法
US11366116B1 (en) 2017-04-12 2022-06-21 National Technology & Engineering Solutions Of Sandia, Llc Real time autonomous surveillance of pathogens
CN110809495A (zh) 2017-04-26 2020-02-18 伯克利之光生命科技公司 使用具有优化电润湿表面的微流体装置的生物处理系统和方法
WO2018202864A1 (fr) 2017-05-05 2018-11-08 bioMérieux Procédé de détection d'une réponse cellulaire immune
WO2018205035A1 (en) 2017-05-12 2018-11-15 Genomedx Biosciences, Inc Genetic signatures to predict prostate cancer metastasis and identify tumor agressiveness
US10914729B2 (en) 2017-05-22 2021-02-09 The Trustees Of Princeton University Methods for detecting protein binding sequences and tagging nucleic acids
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
JP7127023B2 (ja) 2017-06-23 2022-08-29 栄研化学株式会社 核酸検出方法、核酸検出用プライマー及び核酸検出用キット
WO2019073049A1 (en) 2017-10-12 2019-04-18 Danmarks Tekniske Universitet ISOTHERMIC AMPLIFICATION IN SOLID PHASE
AU2018355575A1 (en) 2017-10-27 2020-05-21 Juno Diagnostics, Inc. Devices, systems and methods for ultra-low volume liquid biopsy
US10689629B1 (en) 2017-12-06 2020-06-23 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
US10724017B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
US10724083B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
CA3123182A1 (en) 2017-12-14 2019-06-20 Medicinal Genomics Corporation Methods and kits for classifying cannabinoid production in cannabis plants
WO2019149963A1 (en) 2018-02-05 2019-08-08 Syngenta Participations Ag Methods for detecting fungi in turf grass with a lamp assay having novel primer sets
JP7176682B2 (ja) 2018-02-22 2022-11-22 佐藤製薬株式会社 白癬菌の遺伝子をｌａｍｐ法により検出するためのプライマーセット及びそれを含むキット並びにそれらを用いて白癬菌を検出する方法
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
EP3789504A4 (de) 2018-04-20 2021-12-29 Epigeneron, Inc. Verfahren zur detektion von unterschieden in einer referenzsequenz in einem zielnukleinsäurebereich
US12049665B2 (en) 2018-06-12 2024-07-30 Accuragen Holdings Limited Methods and compositions for forming ligation products
FR3085689A1 (fr) 2018-09-12 2020-03-13 Biomerieux Procede pour determiner in vitro ou ex vivo le statut immunitaire d'un individu
US12071670B2 (en) 2018-06-29 2024-08-27 bioMérieux Method for determining in vitro or ex vivo the immune status of an individual
US20210310059A1 (en) 2018-08-08 2021-10-07 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
AU2019390691A1 (en) 2018-11-28 2021-05-13 Keygene N.V. Targeted enrichment by endonuclease protection
GB2588716B (en) 2018-12-07 2023-11-01 Element Biosciences Inc Flow cell device and use thereof
CN113302314A (zh) 2019-01-15 2021-08-24 3M创新有限公司 用于产志贺毒素大肠杆菌(stec)检测的环介导的等温扩增引物
WO2020169830A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
EP3937780A4 (de) 2019-03-14 2022-12-07 InSilixa, Inc. Verfahren und systeme zur zeitgesteuerten fluoreszenzbasierten detektion
EP3708678A1 (de) 2019-03-15 2020-09-16 Adisseo France S.A.S. Verfahren zur identifizierung eines stresszustands in einer person
JP2022525953A (ja) 2019-03-27 2022-05-20 ジュノ ダイアグノスティックス，インク． 最適化された超微量リキッドバイオプシーの方法、システム、およびデバイス
JP7413362B2 (ja) 2019-03-29 2024-01-15 シスメックス株式会社 新規人工核酸、その製造方法及び用途
AR120629A1 (es) 2019-07-23 2022-03-02 Laboratorio Pablo Cassara S R L Kit de diagnóstico de fundamento molecular para la detección de secuencias nucleotídicas, y métodos para detectar agentes infecciosos usando dicho kit
WO2021026228A1 (en) 2019-08-05 2021-02-11 Mission Bio, Inc. Method and apparatus for single-cell analysis for determining a cell trajectory
US20220298548A1 (en) 2019-08-23 2022-09-22 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
FR3101358A1 (fr) 2019-09-27 2021-04-02 Bioaster Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
EP4038202A1 (de) 2019-10-01 2022-08-10 Biomérieux Verfahren zum bestimmen der ansprechbarkeit eines individuums auf einen stimulus
FR3101423A1 (fr) 2019-10-01 2021-04-02 bioMérieux Procédé pour déterminer la capacité d’un individu à répondre à un stimulus
SG10201910254YA (en) * 2019-11-04 2021-06-29 Denka Company Ltd Nucleic Acid Detection Method Using Lamp And Probe Detection
EP4060039A4 (de) * 2019-11-15 2024-01-03 Public University Corporation Yokohama City University Sensitives nachweisverfahren für undifferenzierte markergene
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
JP2023506631A (ja) 2019-12-20 2023-02-17 キージーン ナムローゼ フェンノートシャップ 共有結合で閉端された核酸分子末端を使用したｎｇｓライブラリー調製
FR3107282A1 (fr) 2020-02-14 2021-08-20 Enalees Trousses et procédés pour l’extraction d’acides nucléiques à partir d’échantillons complexes
JP2023515397A (ja) 2020-02-17 2023-04-13 スリーエム イノベイティブ プロパティズ カンパニー ビブリオ・パラヘモリティカス検出のためのループ介在等温増幅プライマー及びその使用
CN115151656A (zh) 2020-02-27 2022-10-04 荣研化学株式会社 检测单链rna病毒的方法
CN115176036A (zh) 2020-03-05 2022-10-11 荣研化学株式会社 冠状病毒(SARS-CoV-2)的检测方法
FR3108124A1 (fr) 2020-03-10 2021-09-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé pour détecter et éventuellement quantifier un analyte avec un oligonucléotide à double structure tige-boucle et ledit oligonucléotide
EP3878971A1 (de) 2020-03-10 2021-09-15 Commissariat à l'énergie atomique et aux énergies alternatives Verfahren zum nachweis und gegebenenfalls zur quantifizierung eines analyten mit einem oligonukleotid mit doppelter haarnadelstruktur und dieses oligonukleotid
US11345970B2 (en) 2020-03-12 2022-05-31 New England Biolabs, Inc. Rapid diagnostic test for LAMP
US11732315B2 (en) 2020-03-12 2023-08-22 New England Biolabs, Inc. Rapid diagnostic test for lamp
WO2021183921A1 (en) 2020-03-12 2021-09-16 New England Biolabs, Inc. A rapid diagnostic test for lamp
US10968493B1 (en) 2020-03-12 2021-04-06 New England Biolabs, Inc. Rapid diagnostic test using colorimetric LAMP
WO2021183941A1 (en) 2020-03-13 2021-09-16 Uh-Oh Labs Inc. Looped primer and loop-de-loop method for detecting target nucleic acid
AU2021240092A1 (en) 2020-03-20 2022-10-27 Mission Bio, Inc. Single cell workflow for whole genome amplification
US11149320B1 (en) 2020-03-31 2021-10-19 Diasorin S.P.A. Assays for the detection of SARS-CoV-2
BR112022021086A2 (pt) 2020-04-30 2022-12-13 Stab Vida Investig E Servicos Em Ciencias Biologicas Lda Sistema integrado para a detecção e identificação de sequências específicas de ácidos nucleicos e método de utilização do sistema integrado
US20240279750A1 (en) 2020-05-05 2024-08-22 Genomtec Sa Diagnostic Primers, Kits and Methods for Viral Detection
EP4165218A1 (de) 2020-06-12 2023-04-19 Sherlock Biosciences, Inc. Sars-cov-2-detektion auf crispr-basis
FR3112208A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112211A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112207A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112209A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de complication chez un patient
FR3112210A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
US11904314B2 (en) 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
US11898197B2 (en) 2020-07-30 2024-02-13 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
WO2022040443A2 (en) 2020-08-21 2022-02-24 New England Biolabs, Inc. A rapid diagnostic test for lamp
US12110542B2 (en) 2020-09-10 2024-10-08 University Of Connecticut Isothermal amplification
WO2022065413A1 (ja) 2020-09-25 2022-03-31 株式会社理研ジェネシス 新規人工核酸、その製造方法及び用途
WO2022074058A1 (en) 2020-10-06 2022-04-14 Keygene N.V. Targeted sequence addition
JPWO2022075403A1 (de) 2020-10-08 2022-04-14
EP3992300A1 (de) 2020-10-30 2022-05-04 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Probenvorbehandlung zur isothermen amplifikation
WO2022095924A1 (en) 2020-11-05 2022-05-12 Becton, Dickinson And Company Multiplex detection of bacterial respiratory pathogens
EP4240876A1 (de) 2020-11-05 2023-09-13 Becton, Dickinson and Company Multiplex-nachweis und typisierung von vibrio cholerae
JP2023547535A (ja) 2020-11-05 2023-11-10 ベクトン・ディキンソン・アンド・カンパニー ビブリオ・パラヘモリティクスの迅速な同定及び分類
EP4244385A1 (de) 2020-11-10 2023-09-20 MultiplexDX, s.r.o. Loop-vermittelte isothermale nukleinsäureamplifikation (lamp) mit lna-modifizierten primern und ein metallbasiertes kolorimetrisches verfahren zum nachweis eines amplifikationsprodukts
WO2022106795A1 (fr) 2020-11-20 2022-05-27 bioMérieux Procédé de classification d'un individu
WO2022112316A1 (en) 2020-11-24 2022-06-02 Keygene N.V. Targeted enrichment using nanopore selective sequencing
WO2022112394A1 (en) 2020-11-25 2022-06-02 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
JP6972291B1 (ja) 2020-12-24 2021-11-24 栄研化学株式会社 核酸増幅方法、核酸増幅方法用プライマーセット、プローブ、及びキット
WO2022159874A1 (en) 2021-01-25 2022-07-28 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
US11788129B2 (en) 2021-02-23 2023-10-17 Industrial Technology Research Institute Nucleic acid detection kit and nucleic acid detection method
AU2022232600A1 (en) 2021-03-09 2023-09-14 Illumina, Inc. Analyzing expression of protein-coding variants in cells
CA3209074A1 (en) 2021-03-09 2022-09-15 Andrew Kennedy Genomic library preparation and targeted epigenetic assays using cas-grna ribonucleoproteins
EP4314350A1 (de) 2021-03-23 2024-02-07 Life Technologies Corporation Zusammensetzungen, kits und verfahren für den variantenresistenten nachweis von zielvirussequenzen
WO2022226870A1 (zh) * 2021-04-29 2022-11-03 中国科学院大学宁波生命与健康产业研究院 恒温条件下合成核酸的方法及试剂盒和应用
FR3125065A1 (fr) 2021-07-08 2023-01-13 bioMérieux Procédé et kit de détection d’un virus respiratoire réplicatif
CN118339310A (zh) 2021-08-02 2024-07-12 生命科技股份有限公司 用于检测核酸序列负荷的组合物、试剂盒和方法
EP4381094A1 (de) 2021-08-03 2024-06-12 Wageningen Universiteit Argonautenbasiertes nukleinsäurenachweissystem
CA3223731A1 (en) 2021-08-11 2023-02-16 Illumina, Inc. Detection of analytes using targeted epigenetic assays, proximity-induced tagmentation, strand invasion, restriction, or ligation
FR3126983A1 (fr) 2021-09-15 2023-03-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Oligonucléotide à double structure tige-boucle et utilisation dans la détection d’analytes d’intérêt
WO2023069604A1 (en) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
EP4426854A1 (de) 2021-11-02 2024-09-11 Life Technologies Corporation Zusammensetzungen und verfahren zur verringerung der verunreinigung von mastergemischen
KR20230078548A (ko) 2021-11-24 2023-06-02 주식회사 위즈바이오솔루션 루프-매개 등온 증폭 방법에서 다중 검출을 위한 형광 표지 물질 프라이머 셋트 및 이를 이용한 분자 진단 방법
CN118434883A (zh) 2021-12-24 2024-08-02 豪夫迈·罗氏有限公司 Lamp扩增产物的改进检测
FR3131315A1 (fr) 2021-12-27 2023-06-30 Commissariat A L'energie Atomique Et Aux Energies Alternatives Oligonucléotide linéaire et utilisation dans la détection d’analytes d’intérêt
WO2023127857A1 (ja) 2021-12-27 2023-07-06 株式会社理研ジェネシス 新規人工核酸、その製造方法及び用途
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
FR3139579A1 (fr) 2022-09-09 2024-03-15 bioMérieux Procédé de détection in vitro ou ex vivo d’un statut immunodéprimé chez un sujet
WO2024110392A1 (en) 2022-11-22 2024-05-30 bioMérieux New nucleic acid binding compounds and uses
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
WO2024133893A1 (en) 2022-12-22 2024-06-27 Keygene N.V. Nucleotide sequencing data compression
FR3144165A1 (fr) 2022-12-27 2024-06-28 Commissariat A L'energie Atomique Et Aux Energies Alternatives Méthode pour contrôler la qualité d’une amplification lamp et kit utilisé a cet effet
WO2024148013A1 (en) 2023-01-02 2024-07-11 Life Technologies Corporation Compositions, kits and methods for detection of viral sequences
US20240254568A1 (en) 2023-01-27 2024-08-01 Life Technologies Corporation Compositions, kits, and methods for detecting sti pathogen sequences
WO2024170798A1 (fr) 2023-02-17 2024-08-22 Naos Institute Of Life Science Procede de selection d'un compose ecobiologique apte a augmenter le seuil de tolerance de la peau
WO2024209000A1 (en) 2023-04-04 2024-10-10 Keygene N.V. Linkers for duplex sequencing

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6197563B1 (en) * 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5104791A (en) * 1988-02-09 1992-04-14 E. I. Du Pont De Nemours And Company Particle counting nucleic acid hybridization assays
JP2650159B2 (ja) * 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
DE4010465A1 (de) 1990-03-31 1991-10-02 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleinsaeuretemplates und zur bestimmung von nukleinsaeuren
US5595891A (en) 1990-07-19 1997-01-21 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5525462A (en) 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5714323A (en) * 1991-08-30 1998-02-03 The University Of Medecine And Dentistry Of New Jersey Over expression of single-stranded molecules
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
CA2080305A1 (en) 1991-10-11 1993-04-12 Linda M. Western Method for producing a polynucleotide for use in single primer amplification and phosphorothioate-containing oligonucleotides as primers in nucleic acid amplification
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
JPH08503843A (ja) 1992-04-27 1996-04-30 リサーチ コーポレーション テクノロジーズ インコーポレーテッド ウレアプラズマウレアリチカムの検出用オリゴヌクレオチド及び核酸
AU689789B2 (en) * 1993-07-23 1998-04-09 Gen-Probe Incorporated Methods for enhancing nucleic acid amplification
FR2708288B1 (fr) * 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
JPH09505556A (ja) 1993-08-18 1997-06-03 クロマジェン インク 蛍光性ｎ−ヌクレオシド及び蛍光性ｎ−ヌクレオシド構造類似体の応用
US5547861A (en) * 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5686271A (en) 1994-06-09 1997-11-11 Gamera Bioscience Corporation Apparatus for performing magnetic cycle reaction
FR2721945B1 (fr) * 1994-07-04 1996-10-18 David Fabrice Accroissement genique, un procede d'amplicication genique isotherme et ses applications
FR2726277B1 (fr) * 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5665545A (en) 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
US6270962B1 (en) * 1995-01-30 2001-08-07 The Regents Of The University Of California Methods for the elimination of DNA sequencing artifacts
US5674683A (en) 1995-03-21 1997-10-07 Research Corporation Technologies, Inc. Stem-loop and circular oligonucleotides and method of using
GB9507238D0 (en) * 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
WO1997004131A1 (en) * 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
US5866331A (en) 1995-10-20 1999-02-02 University Of Massachusetts Single molecule detection by in situ hybridization
JPH09168400A (ja) * 1995-12-20 1997-06-30 Sekisui Chem Co Ltd 核酸の定量方法
US5972618A (en) * 1997-08-28 1999-10-26 Bloch; Will Detection of mutations in nucleic acids by chemical cleavage
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6794133B1 (en) * 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
JP3115270B2 (ja) * 1997-12-19 2000-12-04 コナミ株式会社 ゲームシステムおよびゲーム用プログラムが記録されたコンピュータ読み取り可能な記録媒体
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
EP1873260B1 (de) * 1998-11-09 2009-03-18 Eiken Kagaku Kabushiki Kaisha Prozess zur Synthetisierung von Nukleinsäure
WO2001077317A1 (en) * 2000-04-07 2001-10-18 Eiken Kagaku Kabushiki Kaisha Method of amplifying nucleic acid by using double-stranded nucleic acid as template
WO2004040019A1 (ja) * 2002-10-29 2004-05-13 Riken 核酸の増幅法

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EP1873260B1 (de) 2009-03-18
JP4139424B2 (ja) 2008-08-27
EP1020534A4 (de) 2004-12-08
EP1020534B2 (de) 2011-01-05
US20040132144A1 (en) 2004-07-08
DE69937223D1 (de) 2007-11-15
US20170107568A1 (en) 2017-04-20
US20020168676A1 (en) 2002-11-14
ES2393056T3 (es) 2012-12-18
US20090098566A1 (en) 2009-04-16
WO2000028082A1 (fr) 2000-05-18
US6974670B2 (en) 2005-12-13

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