ATE374833T1 - Verfahren zur synthese von nukleinsäuren - Google Patents

Verfahren zur synthese von nukleinsäuren

Info

Publication number
ATE374833T1
ATE374833T1 AT99954435T AT99954435T ATE374833T1 AT E374833 T1 ATE374833 T1 AT E374833T1 AT 99954435 T AT99954435 T AT 99954435T AT 99954435 T AT99954435 T AT 99954435T AT E374833 T1 ATE374833 T1 AT E374833T1
Authority
AT
Austria
Prior art keywords
nucleic acid
synthesis
primer
synthesizing
nucleic acids
Prior art date
Application number
AT99954435T
Other languages
English (en)
Inventor
Tsugunori Notomi
Tetsu Hase
Original Assignee
Eiken Chemical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18088663&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE374833(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eiken Chemical filed Critical Eiken Chemical
Application granted granted Critical
Publication of ATE374833T1 publication Critical patent/ATE374833T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/161—Modifications characterised by incorporating target specific and non-target specific sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/125—Specific component of sample, medium or buffer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/119—Strand displacement amplification [SDA]
AT99954435T 1998-11-09 1999-11-08 Verfahren zur synthese von nukleinsäuren ATE374833T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP31747698 1998-11-09

Publications (1)

Publication Number Publication Date
ATE374833T1 true ATE374833T1 (de) 2007-10-15

Family

ID=18088663

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99954435T ATE374833T1 (de) 1998-11-09 1999-11-08 Verfahren zur synthese von nukleinsäuren
AT07014809T ATE426045T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsaure
AT09000525T ATE521718T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsäure

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT07014809T ATE426045T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsaure
AT09000525T ATE521718T1 (de) 1998-11-09 1999-11-08 Prozess zur synthetisierung von nukleinsäure

Country Status (9)

Country Link
US (5) US6410278B1 (de)
EP (4) EP1873260B1 (de)
JP (2) JP3313358B2 (de)
AT (3) ATE374833T1 (de)
DE (3) DE69937223T3 (de)
ES (4) ES2320814T3 (de)
HK (3) HK1029378A1 (de)
MY (3) MY117621A (de)
WO (1) WO2000028082A1 (de)

Families Citing this family (373)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003624A1 (en) * 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US6261808B1 (en) 1992-08-04 2001-07-17 Replicon, Inc. Amplification of nucleic acid molecules via circular replicons
US7256020B2 (en) * 1996-11-29 2007-08-14 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
US8445664B2 (en) * 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
EP1873260B1 (de) * 1998-11-09 2009-03-18 Eiken Kagaku Kabushiki Kaisha Prozess zur Synthetisierung von Nukleinsäure
US6692918B2 (en) 1999-09-13 2004-02-17 Nugen Technologies, Inc. Methods and compositions for linear isothermal amplification of polynucleotide sequences
NZ517121A (en) 1999-09-13 2004-05-28 Nugen Technologies Inc Methods and compositions for linear isothermal amplification of polynucleotide sequences
EP1231281B1 (de) 1999-11-08 2006-02-01 Eiken Kagaku Kabushiki Kaisha Methode zum nachweis von variationen oder polymorphismen
JP4721603B2 (ja) * 1999-11-08 2011-07-13 栄研化学株式会社 変異および／または多型の検出方法
JP4726381B2 (ja) * 2000-04-07 2011-07-20 栄研化学株式会社 ２本鎖核酸を鋳型とする核酸の増幅方法
US7846733B2 (en) 2000-06-26 2010-12-07 Nugen Technologies, Inc. Methods and compositions for transcription-based nucleic acid amplification
ATE437225T1 (de) 2000-09-19 2009-08-15 Eiken Chemical Verfahren zur polynukleotidsynthese
AU2001296015A1 (en) * 2000-10-27 2002-05-06 Eiken Kagaku Kabushiki Kaisha Method of synthesizing single-stranded nucleic acid
JP2002171999A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
JP2002171998A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
JP2002171997A (ja) * 2000-12-08 2002-06-18 Olympus Optical Co Ltd 核酸増幅反応測定方法及び装置
DE60142709D1 (de) 2000-12-13 2010-09-09 Nugen Technologies Inc Methoden und zusammensetzungen zur generierung einer vielzahl von kopien von nukleinsäuresequenzen und methoden zur detektion derselben
JP2002186481A (ja) * 2000-12-18 2002-07-02 Eiken Chem Co Ltd 光学的特性の測定による核酸増幅産物の検出方法
WO2002062993A1 (fr) * 2001-02-06 2002-08-15 Takara Bio Inc. Acides nucleiques amplifies et produits immobilises de ces derniers
BR0205268A (pt) * 2001-03-09 2004-11-30 Nugen Technologies Inc Processos e composições para a mplificação de sequências de rna
JP2002272475A (ja) * 2001-03-22 2002-09-24 Eiken Chem Co Ltd 蛍光偏光法による核酸増幅産物の検出方法
WO2002090538A1 (fr) * 2001-05-08 2002-11-14 Eiken Kagaku Kabushiki Kaisha Procede de synthese d'acide nucleique
US8137911B2 (en) 2001-05-22 2012-03-20 Cellscript, Inc. Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
US7838270B2 (en) 2001-05-22 2010-11-23 The University Of Chicago Target-dependent transcription using deletion mutants of N4 RNA polymerase
JP2002345499A (ja) * 2001-05-29 2002-12-03 Eiken Chem Co Ltd 核酸配列を検出する方法及びその方法に使用するキット
EA006679B1 (ru) * 2001-06-12 2006-02-24 Такара Био Инк. Способ стабилизации реагента для амплификации или детекции нуклеиновой кислоты и способ хранения
JP2005052002A (ja) * 2001-07-06 2005-03-03 Wakunaga Pharmaceut Co Ltd 非環状核酸断片の増幅方法
US7056671B2 (en) 2001-08-20 2006-06-06 Takara Bio Inc. Isothermal chimeric primer nucleic acid amplification methods using blocking oglionucleotide
EP1453979B1 (de) 2001-11-19 2012-01-04 Affymetrix, Inc. Multiplex pcr
US20110151438A9 (en) 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
EP2107113B1 (de) 2002-02-20 2012-04-18 Sysmex Corporation Primer für Nukleinsäureamplifikation bei der Detektion von Haushaltsgen-mRNA und Testverfahren unter Verwendung der Primer
WO2003097878A1 (fr) 2002-05-21 2003-11-27 Sysmex Corporation Amorces d'amplification d'acide nucleique destinees a detecter des cytokeratines et technique d'examen utilisant ces amorces
GB0218215D0 (en) * 2002-08-06 2002-09-11 Tepnel Medical Ltd Amplification of nucleic acids
US20050118616A1 (en) * 2002-08-16 2005-06-02 Kawashima Tadashi R. Amplification of target nucleotide sequence without polymerase chain reaction
AU2003258242A1 (en) * 2002-08-16 2004-03-03 Geneohm Sciences Amplification of target nucleotide sequence without polymerase chain reaction
JP4560285B2 (ja) * 2002-10-02 2010-10-13 栄研化学株式会社 核酸沈澱剤を利用した核酸増幅産物のハイブリダイゼーションアッセイ
EP1564301A4 (de) 2002-10-29 2007-07-11 Riken Verfahren für nukleinsäureamplifikation
JP2004154088A (ja) * 2002-11-08 2004-06-03 Sysmex Corp Ｃｅａ検出のための核酸増幅用プライマーおよび該プライマーを用いた検査方法
AU2003294447A1 (en) 2002-11-21 2004-06-18 Epicentre Technologies Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences
US7851150B2 (en) * 2002-12-18 2010-12-14 Third Wave Technologies, Inc. Detection of small nucleic acids
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
JP4280519B2 (ja) 2003-03-07 2009-06-17 アークレイ株式会社 Ｄｎａ増幅法およびそのためのキット
US7402386B2 (en) * 2003-04-14 2008-07-22 Nugen Technologies, Inc. Global amplification using random priming by a composite primer
EP2292792B1 (de) 2003-05-19 2013-11-20 Gen-Probe Incorporated Zusammensetzungen, Verfahren und Kits zur Bestimmung des Vorliegens von Trichomonas Vaginalis in einer Testprobe
JP4603979B2 (ja) 2003-06-27 2010-12-22 栄研化学株式会社 Ｓａｒｓコロナウイルスの検出法
EP1783497B1 (de) * 2003-08-20 2016-05-11 Sysmex Corporation Behalter für ein Probenanalysegerät
US20050042145A1 (en) * 2003-08-22 2005-02-24 Sysmex Corporation Container for analyzer, detection container, reaction container and packing container for storing detection container
JP4249186B2 (ja) 2003-12-10 2009-04-02 タカラバイオ株式会社 核酸の増幅方法
US8206902B2 (en) 2003-12-25 2012-06-26 Riken Method of amplifying nucleic acid and method of detecting mutated nucleic acid using the same
JP4542345B2 (ja) * 2004-01-15 2010-09-15 シスメックス株式会社 分析装置
JP4505230B2 (ja) * 2004-01-20 2010-07-21 シスメックス株式会社 分析装置
JP4632670B2 (ja) * 2004-01-21 2011-02-16 シスメックス株式会社 濁度検出用光学装置及びそれを用いた濁度検出装置
JP4320266B2 (ja) * 2004-01-22 2009-08-26 シスメックス株式会社 分注装置およびそれを備えた分析装置
US20050164375A1 (en) * 2004-01-23 2005-07-28 Sysmex Corporation Nucleic acid detection apparatus
JP4929153B2 (ja) 2004-03-05 2012-05-09 ジェン−プロウブ インコーポレイテッド 核酸を不活化する際に使用するための試薬、方法、およびキット
WO2005093059A1 (ja) * 2004-03-25 2005-10-06 Sapporo Breweries Limited 酵母、乳酸菌及び偏性嫌気性菌検出・識別のためのプライマー及びプライマーセット並びにそれらを用いた検出・識別方法
AU2005245815B2 (en) 2004-05-07 2011-06-09 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer
ES2401879T3 (es) 2004-08-31 2013-04-25 Eiken Kagaku Kabushiki Kaisha Método de análisis de ácidos nucleicos
JP2008000002A (ja) * 2004-09-30 2008-01-10 Sysmex Corp リブロース２リン酸カルボキシラーゼスモールチェーン１Ａ（ＲＢＣＳ−１Ａ）遺伝子及び／又は該遺伝子のｍＲＮＡを検出するための核酸増幅用プライマ、及び内部標準として該遺伝子及び／又は該遺伝子のｍＲＮＡを用いた検査方法。
US7888014B2 (en) * 2004-10-19 2011-02-15 Nihon University Method of detecting Haemophilus influenzae type b, primer set and kit for the use in the method
ES2382446T3 (es) 2004-11-01 2012-06-08 Eiken Kagaku Kabushiki Kaisha Método de detección del virus de la gripe aviar H5
JP5160725B2 (ja) * 2004-11-02 2013-03-13 シスメックス株式会社 チップラックおよびチップ組立品
EP1819828A2 (de) * 2004-12-11 2007-08-22 CytoGenix, Inc. Zellfreie biosynthese einer hochqualitativen nukleinsäure und verwendungen dafür
EP2348320A3 (de) 2005-03-10 2014-06-25 Gen-Probe Incorporated Systeme und Verfahren zur Erkennung mehrerer optischer Signale
EP2322940B1 (de) 2005-03-10 2014-10-29 Gen-Probe Incorporated Systeme und Verfahren zur Durchführung von Tests zum Nachweis oder zur Quantifizierung von Analyten in Proben
FR2885140B1 (fr) 2005-04-29 2010-12-31 Millipore Corp Procede de detection et de caracterisation de microorgarnismes sur une membrane.
US8679407B2 (en) 2005-05-09 2014-03-25 Theranos, Inc. Systems and methods for improving medical treatments
WO2006123423A1 (ja) * 2005-05-20 2006-11-23 Sapporo Breweries Limited フザリウム属菌検出用プライマー
JP4733456B2 (ja) * 2005-07-26 2011-07-27 シスメックス株式会社 前処理の外部精度管理方法、核酸検出処理の外部精度管理方法、検量線作成処理の外部精度管理方法、前処理の外部精度管理コンピュータ、核酸検出処理の外部精度管理コンピュータ、検量線作成処理の外部精度管理コンピュータ、前処理装置、及び核酸検出装置
JP4798514B2 (ja) 2005-08-10 2011-10-19 国立大学法人浜松医科大学 大腸癌マーカー検出方法
JP2007043997A (ja) * 2005-08-11 2007-02-22 Tosoh Corp 新規な標的核酸の増幅キット
WO2007021004A1 (ja) 2005-08-18 2007-02-22 Eisai R & D Management Co., Ltd. ドーパミン産生ニューロン増殖前駆細胞マーカーＭｓｘ１／２
EP1929045B9 (de) 2005-09-06 2012-06-20 Gen-Probe Incorporated Verfahren, zusammensetzungen und kits zur isothermischen amplifikation von nukleinsäuren
US7939258B2 (en) 2005-09-07 2011-05-10 Nugen Technologies, Inc. Nucleic acid amplification procedure using RNA and DNA composite primers
WO2007044974A2 (en) * 2005-10-12 2007-04-19 The Research Foundation Of State University Of New York Absolute pcr quantification
US7910719B2 (en) * 2005-12-08 2011-03-22 Kabushiki Kaisha Toshiba Method of detecting human papilloma virus by using nucleic acid amplification method and nucleic acid chain-immobilized carrier
JP4516032B2 (ja) * 2006-01-20 2010-08-04 株式会社東芝 ハイブリダイゼーションによる核酸の検出方法およびアッセイキット
JP4580875B2 (ja) 2006-01-20 2010-11-17 株式会社東芝 核酸検出法のためのプライマーの設計方法
WO2007083766A1 (ja) * 2006-01-20 2007-07-26 Olympus Corporation 分子内プローブによる核酸配列の検出方法
JP4881623B2 (ja) 2006-01-27 2012-02-22 シスメックス株式会社 Ｃｅａ核酸増幅用プライマー、プライマーセット、及びがんの診断支援方法
US7488581B2 (en) 2006-03-20 2009-02-10 Kabushiki Kaisha Toshiba Method for detecting a target nucleic acid sequence
US8741230B2 (en) 2006-03-24 2014-06-03 Theranos, Inc. Systems and methods of sample processing and fluid control in a fluidic system
US11287421B2 (en) 2006-03-24 2022-03-29 Labrador Diagnostics Llc Systems and methods of sample processing and fluid control in a fluidic system
US8198081B2 (en) 2006-04-11 2012-06-12 Eisai R&D Management Co., Ltd. Dopaminergic neuron progenitor cell marker 187A5
WO2007123265A1 (ja) * 2006-04-19 2007-11-01 Nihon University 各有莢膜型インフルエンザ菌の検出方法、検出用プライマーセット、 及び検出用キット
US9121056B2 (en) * 2006-04-28 2015-09-01 Igor Kutyavin Use of products of PCR amplification carrying elements of secondary structure to improve PCR-based nucleic acid detection
EP2021488B1 (de) 2006-04-28 2018-09-12 Igor Kutyavin Verwendung von basenmodifizierten deoxynukleosidtriphosphaten für verbesserten nukleinsäurenachweis
AU2007251096A1 (en) 2006-05-16 2007-11-22 Kirin Beer Kabushiki Kaisha Primer set for detection of Dekkera yeast or Brettanomyces yeast
US11001881B2 (en) 2006-08-24 2021-05-11 California Institute Of Technology Methods for detecting analytes
EP2345740B1 (de) 2006-06-06 2015-09-30 Gen-Probe Incorporated Markierte Oligonukleotide und ihre Verwendung in Nukleinsäureverstärkungsverfahren
JP4918409B2 (ja) 2006-07-26 2012-04-18 西川ゴム工業株式会社 核酸配列の増幅方法
US11525156B2 (en) 2006-07-28 2022-12-13 California Institute Of Technology Multiplex Q-PCR arrays
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
EP2049689B1 (de) * 2006-07-31 2011-12-21 Wanli Bi Nukleinsäureverstärkung mithilfe eines reversibel modifizierten oligonukleotids
EP2520935A3 (de) 2006-08-09 2013-02-13 Homestead Clinical Corporation Organspezifische Proteine und Verfahren zu deren Verwendung
US11560588B2 (en) 2006-08-24 2023-01-24 California Institute Of Technology Multiplex Q-PCR arrays
KR20090046876A (ko) * 2006-08-31 2009-05-11 도요 세이칸 가부시키가이샤 핵산의 증폭방법
EP2079754B1 (de) 2006-10-04 2017-03-15 Third Wave Technologies, Inc. Snap-back primer und nachweisbare hairpin-strukturen
US20100216127A1 (en) * 2006-10-05 2010-08-26 Kirin Beer Kabushiki Kaisha Primer set for use in detection of yeast of genus saccharomyces
WO2008058018A2 (en) 2006-11-02 2008-05-15 Mayo Foundation For Medical Education And Research Predicting cancer outcome
JP2008136386A (ja) * 2006-11-30 2008-06-19 Sapporo Breweries Ltd ホップ潜在ウイルスの検出方法、検出用プライマーセット及び検出用キット
JP2008136389A (ja) * 2006-11-30 2008-06-19 Sapporo Breweries Ltd アップルモザイクウイルスの検出方法、検出用プライマーセット及び検出用キット
JP2008194028A (ja) 2007-01-15 2008-08-28 Sysmex Corp 胃がんのリンパ節転移判定方法
CN101605911A (zh) 2007-01-17 2009-12-16 梅里第安生物科学公司 有效用于核酸的环-介导的等温扩增(lamp)的稳定试剂和试剂盒
JP4331216B2 (ja) 2007-02-09 2009-09-16 株式会社東芝 遺伝子変異の検出方法
JP2008212009A (ja) 2007-02-28 2008-09-18 Sysmex Corp Ｄｎａメチル化検出用試料の調製方法
EP2131193A4 (de) 2007-03-05 2010-10-20 Eisai R&D Man Co Ltd Verfahren zur untersuchung der aktivität eines antikrebsmittels mit verwendung einer verringerung des genexpressionsniveaus als mass
JPWO2008111464A1 (ja) 2007-03-05 2010-06-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 スプライシング異常を指標とする抗ガン剤の作用検定方法
CA2622649C (en) 2007-03-09 2018-04-24 Riken Nucleic acid amplification method using primer exhibiting exciton effect
WO2008116186A1 (en) 2007-03-22 2008-09-25 Keck Graduate Institute Systems and devices for isothermal biochemical reactions and/or analysis
JP4410269B2 (ja) * 2007-03-28 2010-02-03 株式会社東芝 Ｎ−アセチルトランスフェラーゼ２（ｎａｔ２）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法
JP4410268B2 (ja) * 2007-03-28 2010-02-03 株式会社東芝 メチレンテトラヒドロ葉酸還元酵素（ｍｔｈｆｒ）の遺伝子型を検出するための核酸プライマーセット及び核酸プローブ
JP4490988B2 (ja) 2007-04-26 2010-06-30 株式会社東芝 血清アミロイドａ１（ｓａａ１）の遺伝子型を検出するための核酸プライマーセット、キット、及び該プライマーセットを用いた検出方法
ES2397115T3 (es) 2007-05-28 2013-03-04 Ehime University Cebadores para detectar Plasmodium
JP2009000044A (ja) * 2007-06-21 2009-01-08 Hitachi High-Technologies Corp 核酸増幅法
EP2191897B1 (de) 2007-06-21 2014-02-26 Gen-Probe Incorporated Instrument und Behälter zur Durchführung von Verfahren
JP4551917B2 (ja) * 2007-07-18 2010-09-29 株式会社東芝 ヒトチトクロームｐ４５０（ｃｙｐ）２ｄ６遺伝子変異の検出方法
WO2009042291A2 (en) * 2007-08-03 2009-04-02 Igor Kutyavin Accelerated cascade amplification (aca) of nucleic acids comprising strand and sequence specific dna nicking
NZ584963A (en) 2007-10-02 2012-11-30 Theranos Inc Modular Point-of-care devices as addressible assay units with tips of assay units having interior to immobilize reagents by capillary action
WO2009054510A1 (ja) 2007-10-25 2009-04-30 Riken 等温増幅方法およびそれに用いるｄｎａポリメラーゼ
EP2058406A3 (de) * 2007-11-06 2009-10-28 Fujifilm Corporation RNA-Detektionsverfahren
EP2232259B1 (de) 2008-01-09 2016-10-12 Keck Graduate Institute System, vorrichtung und verfahren zur materialvorbereitung und/oder -handhabung
US8034568B2 (en) 2008-02-12 2011-10-11 Nugen Technologies, Inc. Isothermal nucleic acid amplification methods and compositions
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US7846666B2 (en) 2008-03-21 2010-12-07 Nugen Technologies, Inc. Methods of RNA amplification in the presence of DNA
JPWO2009119331A1 (ja) 2008-03-28 2011-07-21 シスメックス株式会社 サイトケラチン７のｍＲＮＡの検出用プライマを含む試薬
EP2806037B1 (de) 2008-05-13 2016-09-21 Gen-Probe Incorporated Inaktivierbare Target-Capture-Oligomere zur Verwendung bei der selektiven Hybridisierung und beim Fangen von Zielnukleinsäuresequenzen
EP2806054A1 (de) 2008-05-28 2014-11-26 Genomedx Biosciences Inc. Systeme und Verfahren zur expressionsbasierten Unterscheidung verschiedener klinischer Krankheitszustände bei Prostatakrebs
CN103923991B (zh) 2008-05-28 2016-04-20 花王株式会社 耐热菌类的检测方法
EP2298885A4 (de) * 2008-05-29 2012-12-19 Sysmex Corp Primer zum nachweis von tyrosinase-mrna
EP2325309B1 (de) 2008-05-29 2014-10-22 Kao Corporation Verfahren zum nachweis von paecilomyces variotii
US10407731B2 (en) 2008-05-30 2019-09-10 Mayo Foundation For Medical Education And Research Biomarker panels for predicting prostate cancer outcomes
JP5383105B2 (ja) * 2008-06-30 2014-01-08 キユーピー株式会社 オリゴヌクレオチド及びこれをプライマーとして用いたバチルス・コアグランスの検出法
WO2010030716A1 (en) * 2008-09-10 2010-03-18 Igor Kutyavin Detection of nucleic acids by oligonucleotide probes cleaved in presence of endonuclease v
US9080211B2 (en) 2008-10-24 2015-07-14 Epicentre Technologies Corporation Transposon end compositions and methods for modifying nucleic acids
DK2376517T3 (da) 2008-10-24 2013-02-11 Epict Technologies Corp Transposon-ende-sammensætninger og fremgangsmåder til at modificere nukleinsyrer
US9495515B1 (en) 2009-12-09 2016-11-15 Veracyte, Inc. Algorithms for disease diagnostics
US10236078B2 (en) 2008-11-17 2019-03-19 Veracyte, Inc. Methods for processing or analyzing a sample of thyroid tissue
US20110236900A1 (en) 2008-11-27 2011-09-29 Riken Novel muts protein and method for determing mutation using the same
CA2748364C (en) 2008-12-25 2018-04-17 Universal Bio Research Co., Ltd. Method for pretreating specimen and method for assaying biological substance
US20100285473A1 (en) * 2009-01-27 2010-11-11 John Wolff Thermophilic helicase dependent amplification technology with endpoint homogenous fluorescent detection
JP5586631B2 (ja) 2009-01-30 2014-09-10 ジェン−プローブ・インコーポレーテッド 信号を検出し、信号伝送要素に熱エネルギーを加えるためのシステム及び方法
US8409805B2 (en) * 2009-02-13 2013-04-02 Asuragen, Inc. Method of amplification of GC-rich DNA templates
US9074258B2 (en) 2009-03-04 2015-07-07 Genomedx Biosciences Inc. Compositions and methods for classifying thyroid nodule disease
ES2629400T3 (es) * 2009-03-24 2017-08-09 Asuragen, Inc. Métodos de PCR para caracterizar la región 5' no traducida de los genes FMR1 y FMR2
JP6078339B2 (ja) 2009-05-07 2017-02-08 ベラサイト インコーポレイテッド 甲状腺状態の診断のための方法および組成物
CA2766517A1 (en) 2009-06-26 2010-12-29 Claremont Biosolutions Llc Capture and elution of bio-analytes via beads that are used to disrupt specimens
EP2272980A1 (de) * 2009-07-09 2011-01-12 Bioesplora SRL Molekulare Sonden zum Nachweis und zur Quantifizierung von Target-Nukleinsäure
ATE554189T1 (de) 2009-07-10 2012-05-15 Biotrin Internat Ltd Hochsensibles schnelles isothermisches verfahren zur detektion von punktmutationen und snps
CN102549154A (zh) 2009-07-17 2012-07-04 东洋制罐株式会社 核酸扩增方法
EP2287335A1 (de) 2009-08-05 2011-02-23 DiaSorin S.p.A. Hoch empfindliches schnelles isothermisches Verfahren zur Erkennung von Methylierungsstrukturen
CN102869385A (zh) * 2009-08-18 2013-01-09 巴克斯特国际公司 针对组织因子途径抑制物的适体和其作为出血病症治疗剂的用途
US8598327B2 (en) 2009-08-18 2013-12-03 Baxter International Inc. Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
EP2473624B1 (de) 2009-08-31 2019-05-01 Gen-Probe Incorporated Test für dengue-virus
WO2011037802A2 (en) 2009-09-28 2011-03-31 Igor Kutyavin Methods and compositions for detection of nucleic acids based on stabilized oligonucleotide probe complexes
US10446272B2 (en) 2009-12-09 2019-10-15 Veracyte, Inc. Methods and compositions for classification of samples
CA2896129C (en) 2010-01-22 2015-12-29 Gen-Probe Incorporated Probes for detecting the presence of trichomonas vaginalis in a sample
JP2012000031A (ja) 2010-06-15 2012-01-05 Sysmex Corp 肺がんのリンパ節転移の検査方法、肺がんのリンパ節転移判定装置およびコンピュータプログラム
AU2011272868B2 (en) 2010-06-30 2015-09-17 Gen-Probe Incorporated Method and apparatus for identifying analyte-containing samples using single-read determination of analyte and process control signals
US20130236893A1 (en) 2010-09-02 2013-09-12 Tokushukai Method of detecting type ii diabetes
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
AU2011317073B2 (en) 2010-10-22 2016-04-07 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012061283A1 (en) 2010-11-04 2012-05-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rapid molecular assays for specific detection and quantitation of loa loa microfilaremia
TWI435935B (zh) * 2010-12-06 2014-05-01 Univ Nat Cheng Kung 快速檢測標靶核酸片段之套組及方法
JP6126381B2 (ja) 2010-12-10 2017-05-10 国立大学法人東京工業大学 標的核酸の検出方法及びキット
JP5945282B2 (ja) 2011-01-21 2016-07-05 セラノス， インコーポレイテッド 試料使用の極大化のためのシステム及び方法
CA3082652A1 (en) 2011-04-15 2012-10-18 Becton, Dickinson And Company Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection
WO2013002354A1 (ja) 2011-06-29 2013-01-03 株式会社ダナフォーム 生体試料の前処理方法、ｒｎａの検出方法及び前処理キット
GB201112140D0 (en) 2011-07-14 2011-08-31 Dna Electronics Nucleic acid amplification
JP5299981B1 (ja) * 2011-09-08 2013-09-25 独立行政法人理化学研究所 プライマーセット及びそれを用いた標的核酸配列の増幅方法並びに変異核酸の検出方法
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9175337B2 (en) 2011-09-21 2015-11-03 Gen-Probe Incorporated Methods for amplifying nucleic acid using tag-mediated displacement
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
CA2849104A1 (en) 2011-09-25 2013-04-11 Theranos, Inc. Systems and methods for multi-analysis
EP2787077B1 (de) 2011-10-31 2019-10-23 Eiken Kagaku Kabushiki Kaisha Verfahren zum nachweis einer zielnukleinsäure
WO2013067272A1 (en) * 2011-11-04 2013-05-10 Diagnostics For All, Inc. Low cost, disposable molecular diagnostic devices
CA2858581A1 (en) 2011-12-13 2013-06-20 Genomedx Biosciences, Inc. Cancer diagnostics using non-coding transcripts
WO2013129542A1 (ja) 2012-02-29 2013-09-06 独立行政法人理化学研究所 Ｈｌａ－ａ＊３１：０１アレルの検出方法
ES2948896T3 (es) 2012-03-29 2023-09-21 Becton Dickinson Co Acidos nucleicos para la amplificación de ácidos nucleicos
IN2014DN09302A (de) 2012-04-13 2015-07-10 Becton Dickinson Co
EP2876160B1 (de) 2012-07-06 2020-05-13 Kyoto Prefectural Public University Corporation Differenzierungsmarker und differenzierungskontrolle für augenzellen
US20140038182A1 (en) 2012-07-17 2014-02-06 Dna Logix, Inc. Cooperative primers, probes, and applications thereof
EP2888688B1 (de) 2012-07-20 2019-09-04 Asuragen, INC. Umfassende fmr1-genotypisierung
AU2013202793B2 (en) 2012-07-31 2014-09-18 Gen-Probe Incorporated System, method and apparatus for automated incubation
EP3435084B1 (de) 2012-08-16 2023-02-22 Decipher Biosciences, Inc. Prostatakrebsprognose unter verwendung von biomarkern
KR20150055002A (ko) 2012-09-11 2015-05-20 테라노스, 인코포레이티드 생물학적 서명을 이용한 정보 관리 시스템 및 방법
CA2892818A1 (en) 2012-11-28 2014-06-05 Abwiz Bio, Inc. Preparation of gene-specific templates for the use in single primer amplification
JP6200281B2 (ja) 2012-11-29 2017-09-20 シスメックス株式会社 甲状腺腫瘍の性状の判別を補助する方法およびその方法に用いるマーカーセット
EP2956755A4 (de) 2013-02-18 2016-03-30 Theranos Inc Systeme und verfahren zum sammeln und übertragen von testergebnissen
US10545161B2 (en) 2013-03-11 2020-01-28 Cue Health Inc. Systems and methods for detection and quantification of analytes
WO2017015172A1 (en) 2015-07-17 2017-01-26 Cue Inc. Systems and methods for enhanced detection and quantification of analytes
KR101613104B1 (ko) 2013-03-11 2016-04-18 큐 인코퍼레이티드 분석물의 검출 및 정량을 위한 시스템 및 방법
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
AU2013202778A1 (en) 2013-03-14 2014-10-02 Gen-Probe Incorporated Systems, methods, and apparatuses for performing automated reagent-based assays
AU2013202788B2 (en) 2013-03-14 2015-10-01 Gen-Probe Incorporated Indexing signal detection module
AU2014233152A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
EP3360958B1 (de) 2013-03-15 2021-12-22 Labrador Diagnostics LLC Wärmestabile offenendige ligase und verfahren zur verwendung
US9677981B2 (en) 2013-03-15 2017-06-13 3M Innovative Properties Company Sample concentrator and method of use
AU2014237563B2 (en) 2013-03-15 2020-06-11 Becton, Dickinson And Company Detection of neisseria gonorrhoeaes
EP2970961B1 (de) 2013-03-15 2019-04-24 Theranos IP Company, LLC Nukleinsäureamplifikation
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
WO2014150290A1 (en) 2013-03-15 2014-09-25 Theranos, Inc. Devices, systems and methods for sample preparation
MX365323B (es) 2013-03-15 2019-05-29 Theranos Ip Co Llc Amplificación de ácidos nucléicos.
JP6286419B2 (ja) 2013-03-26 2018-02-28 株式会社ニッポンジーン 遺伝子多型の識別に用いるプライマーとプローブのセットおよびその利用
JP5951545B2 (ja) 2013-03-29 2016-07-13 シスメックス株式会社 検体分析装置、検体分析方法、及びコンピュータプログラム
US20160138013A1 (en) 2013-05-30 2016-05-19 The Regents Of The University Of California Substantially unbiased amplification of genomes
CN103276083B (zh) * 2013-05-30 2014-11-19 首都医科大学附属北京友谊医院 肺炎支原体检测试剂盒
MX2016000997A (es) 2013-07-25 2016-04-19 Dch Molecular Diagnostics Inc Metodos y composiciones para detectar contaminacion bacteriana.
JP6548576B2 (ja) 2013-07-30 2019-07-24 京都府公立大学法人 角膜内皮細胞マーカー
KR102398399B1 (ko) 2013-08-09 2022-05-16 루미넥스 코포레이션 핵산 에세이에서의 향상된 용융 식별 및 복합화를 위한 프로브
CA2917206C (en) * 2013-08-09 2021-09-21 Genebio Systems, Inc. Dna amplification via scissor-like structures (dasl)
AU2014317990A1 (en) 2013-09-06 2016-02-25 Theranos Ip Company, Llc Systems and methods for detecting infectious diseases
JP6118223B2 (ja) 2013-09-27 2017-04-19 シスメックス株式会社 液体吸引装置、検体分析装置、およびチップ収容容器
JP6339787B2 (ja) * 2013-10-09 2018-06-06 株式会社日立ハイテクノロジーズ 核酸の分析方法
US10196684B2 (en) 2013-10-18 2019-02-05 California Institute Of Technology Enhanced nucleic acid identification and detection
EP3063272A2 (de) 2013-10-30 2016-09-07 Green Life Biotech, LLC Pathogenesequantifizierungssysteme und behandlungsverfahren für mehltau von zitrusgewächsen
JP2015087329A (ja) 2013-10-31 2015-05-07 シスメックス株式会社 吸引部の位置調整方法及び検体処理装置
CN105940024B (zh) 2013-12-05 2019-03-15 生捷科技控股公司 修饰的表面
CN111118121A (zh) 2013-12-05 2020-05-08 生捷科技控股公司 图案化阵列的制备
EP3077545B1 (de) 2013-12-05 2020-09-16 Centrillion Technology Holdings Corporation Verfahren zur sequenzierung von nukleinsäuren
US11286519B2 (en) 2013-12-11 2022-03-29 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
SG11201604737VA (en) 2013-12-11 2016-07-28 Accuragen Inc Compositions and methods for detecting rare sequence variants
US11859246B2 (en) 2013-12-11 2024-01-02 Accuragen Holdings Limited Methods and compositions for enrichment of amplification products
CA2936157C (en) 2014-01-15 2021-08-24 Tokyo Institute Of Technology Covered sequence conversion dna and detection methods
CN103789436B (zh) * 2014-01-30 2015-09-30 思博奥科生物信息科技（北京）有限公司 一种基于人工修饰引物的定量突变检测系统
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
EA037029B1 (ru) 2014-03-31 2021-01-28 КАБУСИКИ КАЙСЯ ДиЭнЭйФОРМ Флуоресцентно меченная одноцепочечная нуклеиновая кислота и ее применение
USD745423S1 (en) 2014-05-12 2015-12-15 Cue Inc. Automated analyzer test cartridge and sample collection device for analyte detection
WO2015183837A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
WO2015183836A1 (en) 2014-05-27 2015-12-03 Brian Haynes Compositions, methods, and uses related to ntrk2-tert fusions
WO2015187849A2 (en) 2014-06-04 2015-12-10 Lucigen Corporation Sample collection and analysis devices
US10017759B2 (en) 2014-06-26 2018-07-10 Illumina, Inc. Library preparation of tagged nucleic acid
WO2016011280A1 (en) 2014-07-16 2016-01-21 Tangen Biosciences, Inc. Isothermal methods for amplifying nucleic acid samples
CN113637728A (zh) 2014-08-11 2021-11-12 卢米耐克斯公司 用于在核酸测定中改善解链分辨和多重性的探针
EP3207159B1 (de) 2014-10-14 2019-11-20 Abbott Laboratories Sequenzumwandlungs- und signalverstärker-dna mit poly-dna-spacer-sequenzen und nachweisverfahren damit
JP6491458B2 (ja) 2014-10-31 2019-03-27 シスメックス株式会社 核酸増幅方法
WO2016073353A1 (en) 2014-11-03 2016-05-12 Tangen Biosciences, Inc. Apparatus and method for cell, spore, or virus capture and disruption
CN114606309A (zh) 2014-11-05 2022-06-10 威拉赛特公司 使用机器学习和高维转录数据的诊断系统和方法
ES2706531T3 (es) 2014-11-11 2019-03-29 Illumina Inc Amplificación de polinucleótidos empleando sistemas CRISPR-Cas
US10604790B2 (en) 2014-12-24 2020-03-31 Abbott Laboratories Sequence conversion and signal amplifier DNA cascade reactions and detection methods using same
US10724091B1 (en) 2015-02-10 2020-07-28 National Technology & Engineering Solutions Of Sandia, Llc Endpoint detection of amplified nucleic acids
US9708647B2 (en) 2015-03-23 2017-07-18 Insilixa, Inc. Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays
JP6518110B2 (ja) * 2015-03-31 2019-05-22 株式会社カネカ クレブシエラ・ニューモニエ（Ｋｌｅｂｓｉｅｌｌａｐｎｅｕｍｏｎｉａｅ）を検出するためのプライマー及び方法
US10125198B2 (en) 2015-04-17 2018-11-13 Distributed Bio, Inc. Method for mass humanization of non-human antibodies
US11091799B2 (en) 2015-04-24 2021-08-17 Atila Biosystems Incorporated Amplification with primers of limited nucleotide composition
DK3286323T3 (da) 2015-04-24 2023-03-13 Becton Dickinson Co Multipleks detektion af bakteriel vaginose
WO2016193070A1 (en) 2015-05-29 2016-12-08 Roche Diagnostics Gmbh A method of inactivating microbes by citraconic anhydride
US10260090B2 (en) 2015-07-16 2019-04-16 Arizona Board Of Regents On Behalf Of Arizona State University Accelerated isothermal amplification of DNA
AU2016297631B2 (en) 2015-07-23 2022-08-04 Asuragen, Inc. Methods, compositions, kits, and uses for analysis of nucleic acids comprising repeating A/T-rich segments
US9499861B1 (en) 2015-09-10 2016-11-22 Insilixa, Inc. Methods and systems for multiplex quantitative nucleic acid amplification
EP3359693A4 (de) 2015-10-09 2019-03-06 Accuragen Holdings Limited Verfahren und zusammensetzungen zur anreicherung von amplifikationsprodukten
US20180363039A1 (en) 2015-12-03 2018-12-20 Accuragen Holdings Limited Methods and compositions for forming ligation products
US20190032104A1 (en) 2016-01-21 2019-01-31 T2 Biosystems, Inc. Rapid antimicrobial susceptibility testing using high-sensitivity direct detection methods
EP4218773A1 (de) 2016-02-15 2023-08-02 Kyoto Prefectural Public University Corporation Menschliche funktionelle hornhautendothelzelle und anwendung davon
WO2017155858A1 (en) 2016-03-07 2017-09-14 Insilixa, Inc. Nucleic acid sequence identification using solid-phase cyclic single base extension
US10859579B2 (en) 2016-03-31 2020-12-08 William Beaumont Hospital Methods for detecting, diagnosing and treating ulcerative interstitial cystitis
US20210002715A1 (en) 2016-04-14 2021-01-07 T2 Biosystems, Inc. Methods and systems for amplification in complex samples
EP3455372B1 (de) 2016-05-11 2019-10-30 Illumina, Inc. Polynukleotidanreicherung und -amplifikation unter verwendung von argonautensystemen
WO2017201102A1 (en) 2016-05-16 2017-11-23 Accuragen Holdings Limited Method of improved sequencing by strand identification
JPWO2017212904A1 (ja) * 2016-06-06 2019-04-11 国立大学法人 宮崎大学 複数のプライマーセットを組み合わせたｌａｍｐ法を用いたアフリカ豚コレラウイルスの迅速検出法
CA3033749A1 (en) 2016-08-15 2018-02-22 Accuragen Holdings Limited Compositions and methods for detecting rare sequence variants
US11414708B2 (en) 2016-08-24 2022-08-16 Decipher Biosciences, Inc. Use of genomic signatures to predict responsiveness of patients with prostate cancer to post-operative radiation therapy
JP2019528678A (ja) 2016-09-15 2019-10-17 アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ 試料分析のための装置および方法
US10724089B2 (en) 2016-10-06 2020-07-28 The Board Of Trustees Of The University Of Illinois Spatial molecular analysis of tissue
WO2018129368A2 (en) 2017-01-06 2018-07-12 Editas Medicine, Inc. Methods of assessing nuclease cleavage
EP3571322B9 (de) 2017-01-20 2023-10-04 VERACYTE SD, Inc. Molekulare untertypisierung, prognose und behandlung von blasenkrebs
WO2018140540A1 (en) 2017-01-25 2018-08-02 Cue Health Inc. Systems and methods for enhanced detection and quantification of analytes
AU2018230784A1 (en) 2017-03-09 2019-10-10 Decipher Biosciences, Inc. Subtyping prostate cancer to predict response to hormone therapy
JP6924600B2 (ja) 2017-04-10 2021-08-25 シスメックス株式会社 測定方法、測定装置、プログラム、演算式の取得方法および定性判定結果の表示方法
US11366116B1 (en) 2017-04-12 2022-06-21 National Technology & Engineering Solutions Of Sandia, Llc Real time autonomous surveillance of pathogens
WO2018200872A1 (en) 2017-04-26 2018-11-01 Berkeley Lights, Inc. Biological process systems and methods using microfluidic apparatus having an optimized electrowetting surface
ES2933132T3 (es) 2017-05-05 2023-02-01 Biomerieux Sa Procedimiento para detectar una respuesta celular inmune
AU2018266733A1 (en) 2017-05-12 2020-01-16 Veracyte, Inc. Genetic signatures to predict prostate cancer metastasis and identify tumor aggressiveness
US10914729B2 (en) 2017-05-22 2021-02-09 The Trustees Of Princeton University Methods for detecting protein binding sequences and tagging nucleic acids
US11217329B1 (en) 2017-06-23 2022-01-04 Veracyte, Inc. Methods and systems for determining biological sample integrity
EP3643790A4 (de) 2017-06-23 2021-03-24 Eiken Kagaku Kabushiki Kaisha Verfahren zur nukleinsäuredetektion, primer zur nukleinsäuredetektion und kit zur nukleinsäuredetektion
WO2019073049A1 (en) 2017-10-12 2019-04-18 Danmarks Tekniske Universitet ISOTHERMIC AMPLIFICATION IN SOLID PHASE
WO2019084489A1 (en) 2017-10-27 2019-05-02 Juno Diagnostics, Inc. DEVICES, SYSTEMS AND METHODS FOR ULTRA-LOW VOLUMES LIQUID BIOPSY
US10689629B1 (en) 2017-12-06 2020-06-23 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable circular oligonucleotide ligands
US10724083B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of nucleic acid polymerases by endonuclease V-cleavable oligonucleotide ligands
US10724017B1 (en) 2017-12-06 2020-07-28 Cepheid Inhibition of DNA polymerases by uracil-DNA glycosylase-cleavable oligonucleotide ligands
WO2019118912A1 (en) 2017-12-14 2019-06-20 Medicinal Genomics Corporation Methods and kits for classifying cannabinoid production in cannabis plants
KR20200118071A (ko) 2018-02-05 2020-10-14 신젠타 파티서페이션즈 아게 신규한 프라이머 세트를 갖는 lamp 검정으로 터프 그래스에서 진균을 검출하기 위한 방법
JP7176682B2 (ja) 2018-02-22 2022-11-22 佐藤製薬株式会社 白癬菌の遺伝子をｌａｍｐ法により検出するためのプライマーセット及びそれを含むキット並びにそれらを用いて白癬菌を検出する方法
US11203782B2 (en) 2018-03-29 2021-12-21 Accuragen Holdings Limited Compositions and methods comprising asymmetric barcoding
FR3080185A1 (fr) 2018-04-16 2019-10-18 Biomerieux Evaluation du risque de complication chez un patient suspecte d'avoir une infection ayant un score sofa inferieur a deux
CN111989408A (zh) 2018-04-20 2020-11-24 株式会社艾匹基乃龙 检测靶核酸区域内的与参考序列的差异的方法
FR3085689A1 (fr) 2018-09-12 2020-03-13 Biomerieux Procede pour determiner in vitro ou ex vivo le statut immunitaire d'un individu
WO2020002602A1 (fr) 2018-06-29 2020-01-02 bioMérieux Procédé pour déterminer in vitro ou ex vivo le statut immunitaire d'un individu
JP2021532808A (ja) 2018-08-08 2021-12-02 ジェン−プローブ・インコーポレーテッド Ｍｙｃｏｐｌａｓｍａ ｇｅｎｉｔａｌｉｕｍを検出するための組成物、方法、およびキット
US20220033879A1 (en) 2018-11-28 2022-02-03 Keygene N.V. Targeted enrichment by endonuclease protection
EP3890887A4 (de) 2018-12-07 2022-10-12 Element Biosciences, Inc. Durchflusszellenvorrichtung und deren verwendung
CN113302314A (zh) 2019-01-15 2021-08-24 3M创新有限公司 用于产志贺毒素大肠杆菌(stec)检测的环介导的等温扩增引物
AU2020225760A1 (en) 2019-02-21 2021-08-19 Keygene N.V. Genotyping of polyploids
JP2022525322A (ja) 2019-03-14 2022-05-12 インシリクサ， インコーポレイテッド 時間ゲート蛍光ベースの検出のための方法およびシステム
EP3708678A1 (de) 2019-03-15 2020-09-16 Adisseo France S.A.S. Verfahren zur identifizierung eines stresszustands in einer person
US20220162591A1 (en) 2019-03-27 2022-05-26 Juno Diagnostics, Inc. Optimized ultra-low volume liquid biopsy methods, systems, and devices
CN113646007A (zh) 2019-03-29 2021-11-12 希森美康株式会社 新人工核酸、其制造方法及用途
AR120629A1 (es) 2019-07-23 2022-03-02 Laboratorio Pablo Cassara S R L Kit de diagnóstico de fundamento molecular para la detección de secuencias nucleotídicas, y métodos para detectar agentes infecciosos usando dicho kit
JP2022545280A (ja) 2019-08-23 2022-10-26 ジェン－プローブ・インコーポレーテッド Ｔｒｅｐｏｎｅｍａ ｐａｌｌｉｄｕｍを検出するための組成物、方法、およびキット
FR3101358A1 (fr) 2019-09-27 2021-04-02 Bioaster Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3101423A1 (fr) 2019-10-01 2021-04-02 bioMérieux Procédé pour déterminer la capacité d’un individu à répondre à un stimulus
US20220381791A1 (en) 2019-10-01 2022-12-01 bioMérieux Method for determining an individual ability to respond to a stimulus
SG10201910254YA (en) 2019-11-04 2021-06-29 Denka Company Ltd Nucleic Acid Detection Method Using Lamp And Probe Detection
JP7138841B2 (ja) * 2019-11-15 2022-09-20 公立大学法人横浜市立大学 未分化マーカー遺伝子高感度検出法
JP2023505712A (ja) 2019-12-12 2023-02-10 キージーン ナムローゼ フェンノートシャップ 半固体状態での核酸操作
JP2023506631A (ja) 2019-12-20 2023-02-17 キージーン ナムローゼ フェンノートシャップ 共有結合で閉端された核酸分子末端を使用したｎｇｓライブラリー調製
FR3107282A1 (fr) 2020-02-14 2021-08-20 Enalees Trousses et procédés pour l’extraction d’acides nucléiques à partir d’échantillons complexes
WO2021165828A1 (en) 2020-02-17 2021-08-26 3M Innovative Properties Company Loop-mediated isothermal amplification primers for vibrio parahaemolyticus detection and uses thereof
WO2021172370A1 (ja) 2020-02-27 2021-09-02 栄研化学株式会社 一本鎖ｒｎａウイルスを検出する方法
JP7313537B2 (ja) * 2020-03-05 2023-07-24 栄研化学株式会社 コロナウイルス（ＳＡＲＳ－ＣｏＶ－２）の検出方法
EP3878971A1 (de) 2020-03-10 2021-09-15 Commissariat à l'énergie atomique et aux énergies alternatives Verfahren zum nachweis und gegebenenfalls zur quantifizierung eines analyten mit einem oligonukleotid mit doppelter haarnadelstruktur und dieses oligonukleotid
FR3108124A1 (fr) 2020-03-10 2021-09-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé pour détecter et éventuellement quantifier un analyte avec un oligonucléotide à double structure tige-boucle et ledit oligonucléotide
US11732315B2 (en) 2020-03-12 2023-08-22 New England Biolabs, Inc. Rapid diagnostic test for lamp
US11345970B2 (en) 2020-03-12 2022-05-31 New England Biolabs, Inc. Rapid diagnostic test for LAMP
WO2021183921A1 (en) 2020-03-12 2021-09-16 New England Biolabs, Inc. A rapid diagnostic test for lamp
US10968493B1 (en) 2020-03-12 2021-04-06 New England Biolabs, Inc. Rapid diagnostic test using colorimetric LAMP
BR112022018015A2 (pt) 2020-03-13 2022-12-06 Uh Oh Labs Inc Iniciador em loop e método loop a loop para detectar ácido nucleico alvo
US11149320B1 (en) 2020-03-31 2021-10-19 Diasorin S.P.A. Assays for the detection of SARS-CoV-2
CA3175648A1 (en) 2020-04-30 2021-11-04 Alcino Orfeu De Leao E Flores Method and portable device for detection of nucleic sequences in suspected coronavirus samples
CA3177886A1 (en) 2020-05-05 2021-11-11 Miron TOKARSKI Diagnostic primers, kits and methods for viral detection
CA3186580A1 (en) 2020-06-12 2021-12-16 Sherlock Biosciences, Inc. Crispr-based sars-cov-2 detection
FR3112211A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112207A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112210A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
FR3112209A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de complication chez un patient
FR3112208A1 (fr) 2020-07-06 2022-01-07 bioMérieux Procédé pour déterminer le risque de survenue d’une infection associée aux soins chez un patient
US11898197B2 (en) 2020-07-30 2024-02-13 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
US11904314B2 (en) 2020-07-30 2024-02-20 Wainamics, Inc. System and self-metering cartridges for point of care bioassays
EP4110945A2 (de) 2020-08-21 2023-01-04 New England Biolabs, Inc. Schneller diagnosetest für lampe
CN116322706A (zh) 2020-09-25 2023-06-23 株式会社理真思 新人工核酸、其制造方法和用途
WO2022074058A1 (en) 2020-10-06 2022-04-14 Keygene N.V. Targeted sequence addition
EP4227395A1 (de) 2020-10-08 2023-08-16 National Center for Global Health and Medicine Ein oder mehrere hla-genprimer
EP3992300A1 (de) 2020-10-30 2022-05-04 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO Probenvorbehandlung zur isothermen amplifikation
JP2023547536A (ja) 2020-11-05 2023-11-10 ベクトン・ディキンソン・アンド・カンパニー 細菌性呼吸器病原体のマルチプレックス検出
US20240011106A1 (en) 2020-11-05 2024-01-11 Becton, Dickinson And Company Multiplex detection and typing of vibrio cholerae
AU2021376490A1 (en) 2020-11-05 2023-05-11 Becton, Dickinson And Company Rapid identification and typing of vibrio parahaemolyticus
AU2021378475A1 (en) 2020-11-10 2023-06-15 MultiplexDX, s.r.o. Loop mediated isothermal nucleic acid amplification (lamp) using lna-modified primers and a metal-based colorimetric method for detecting an amplification product
WO2022106795A1 (fr) 2020-11-20 2022-05-27 bioMérieux Procédé de classification d'un individu
EP4251761A1 (de) 2020-11-24 2023-10-04 Keygene N.V. Gezielte anreicherung mittels nanoporenselektiver sequenzierung
US20240093288A1 (en) 2020-11-25 2024-03-21 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
JP6972291B1 (ja) 2020-12-24 2021-11-24 栄研化学株式会社 核酸増幅方法、核酸増幅方法用プライマーセット、プローブ、及びキット
WO2022159874A1 (en) 2021-01-25 2022-07-28 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
US11788129B2 (en) 2021-02-23 2023-10-17 Industrial Technology Research Institute Nucleic acid detection kit and nucleic acid detection method
AU2022234741A1 (en) 2021-03-09 2023-09-14 Illumina Cambridge Limited Genomic library preparation and targeted epigenetic assays using cas-grna ribonucleoproteins
AU2022232600A1 (en) 2021-03-09 2023-09-14 Illumina, Inc. Analyzing expression of protein-coding variants in cells
EP4314350A1 (de) 2021-03-23 2024-02-07 Life Technologies Corporation Zusammensetzungen, kits und verfahren für den variantenresistenten nachweis von zielvirussequenzen
EP4105327A4 (de) * 2021-04-29 2023-01-18 Ningbo Institute of Life and Health Industry University of Chinese Academy of Sciences Verfahren zur herstellung von nukleinsäuren mit konstanter temperatur und kit und verwendung davon
FR3125065A1 (fr) 2021-07-08 2023-01-13 bioMérieux Procédé et kit de détection d’un virus respiratoire réplicatif
WO2023014729A1 (en) 2021-08-02 2023-02-09 Life Technologies Corporation Compositions, kits, and methods for detection of nucleic acid sequence loads
WO2023014222A1 (en) 2021-08-03 2023-02-09 Wageningen Universiteit Argonaute-based nucleic acid detection system
AU2022328378A1 (en) 2021-08-11 2024-01-18 Illumina, Inc. Detection of analytes using targeted epigenetic assays, proximity-induced tagmentation, strand invasion, restriction, or ligation
FR3126983A1 (fr) 2021-09-15 2023-03-17 Commissariat A L'energie Atomique Et Aux Energies Alternatives Oligonucléotide à double structure tige-boucle et utilisation dans la détection d’analytes d’intérêt
WO2023069604A1 (en) 2021-10-20 2023-04-27 Life Technologies Corporation Compositions, kits, and methods for quantification of nucleic acid sequences using an internal quantitative standard
WO2023081221A1 (en) 2021-11-02 2023-05-11 Life Technologies Corporation Compositions and methods for reducing master mix contamination
KR20230078548A (ko) 2021-11-24 2023-06-02 주식회사 위즈바이오솔루션 루프-매개 등온 증폭 방법에서 다중 검출을 위한 형광 표지 물질 프라이머 셋트 및 이를 이용한 분자 진단 방법
WO2023118399A1 (en) 2021-12-24 2023-06-29 F. Hoffmann-La Roche Ag Improved detection of lamp amplification products
FR3131315A1 (fr) 2021-12-27 2023-06-30 Commissariat A L'energie Atomique Et Aux Energies Alternatives Oligonucléotide linéaire et utilisation dans la détection d’analytes d’intérêt
WO2024003114A1 (en) 2022-06-29 2024-01-04 Actome Gmbh Detection of biomolecules in single cells
WO2024054925A1 (en) 2022-09-09 2024-03-14 Life Technologies Corporation Compositions, kits and methods for detection of viral variant sequences
FR3139579A1 (fr) 2022-09-09 2024-03-15 bioMérieux Procédé de détection in vitro ou ex vivo d’un statut immunodéprimé chez un sujet

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6197563B1 (en) * 1985-03-28 2001-03-06 Roche Molecular Systems, Inc. Kits for amplifying and detecting nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5104791A (en) * 1988-02-09 1992-04-14 E. I. Du Pont De Nemours And Company Particle counting nucleic acid hybridization assays
JP2650159B2 (ja) * 1988-02-24 1997-09-03 アクゾ・ノベル・エヌ・ベー 核酸増幅方法
DE4010465A1 (de) 1990-03-31 1991-10-02 Boehringer Mannheim Gmbh Verfahren zur spezifischen vervielfaeltigung von nukleinsaeuretemplates und zur bestimmung von nukleinsaeuren
US5595891A (en) 1990-07-19 1997-01-21 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5455166A (en) * 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5525462A (en) 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5714323A (en) * 1991-08-30 1998-02-03 The University Of Medecine And Dentistry Of New Jersey Over expression of single-stranded molecules
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
ATE161586T1 (de) * 1991-10-11 1998-01-15 Behringwerke Ag Verfahren zur herstellung eines polynukleotids zum gebrauch in ''single-primer'' amplifizierung und phosphorothioat-enthaltende oligonukleotide als primer in nukleinsäureamplifizierung
US5612199A (en) 1991-10-11 1997-03-18 Behringwerke Ag Method for producing a polynucleotide for use in single primer amplification
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
JPH08503843A (ja) 1992-04-27 1996-04-30 リサーチ コーポレーション テクノロジーズ インコーポレーテッド ウレアプラズマウレアリチカムの検出用オリゴヌクレオチド及び核酸
KR100189229B1 (ko) * 1993-07-23 1999-06-01 다니엘 엘. 캐시앙, 헨리 엘. 노르호프 핵산 증폭을 강화하는 방법
FR2708288B1 (fr) * 1993-07-26 1995-09-01 Bio Merieux Procédé d'amplification d'acides nucléiques par transcription utilisant le déplacement, réactifs et nécessaire pour la mise en Óoeuvre de ce procédé.
CA2145750A1 (en) 1993-08-18 1995-02-23 Michael J. Conrad Applications of fluorescent n-nucleosides and fluorescent structural analogs of n-nucleosides
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
US5648211A (en) * 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5686271A (en) * 1994-06-09 1997-11-11 Gamera Bioscience Corporation Apparatus for performing magnetic cycle reaction
FR2721945B1 (fr) 1994-07-04 1996-10-18 David Fabrice Accroissement genique, un procede d'amplicication genique isotherme et ses applications
FR2726277B1 (fr) * 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
US5665545A (en) 1994-11-28 1997-09-09 Akzo Nobel N.V. Terminal repeat amplification method
US6270962B1 (en) * 1995-01-30 2001-08-07 The Regents Of The University Of California Methods for the elimination of DNA sequencing artifacts
US5674683A (en) 1995-03-21 1997-10-07 Research Corporation Technologies, Inc. Stem-loop and circular oligonucleotides and method of using
GB9507238D0 (en) * 1995-04-07 1995-05-31 Isis Innovation Detecting dna sequence variations
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
WO1997004131A1 (en) * 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
US5888731A (en) * 1995-08-30 1999-03-30 Visible Genetics Inc. Method for identification of mutations using ligation of multiple oligonucleotide probes
US5866331A (en) 1995-10-20 1999-02-02 University Of Massachusetts Single molecule detection by in situ hybridization
JPH09168400A (ja) * 1995-12-20 1997-06-30 Sekisui Chem Co Ltd 核酸の定量方法
CA2268368A1 (en) * 1997-08-28 1999-03-11 The Perkin-Elmer Corporation Improved detection of mutations in nucleic acids by chemical cleavage
US7067117B1 (en) 1997-09-11 2006-06-27 Cambridge University Technical Services, Ltd. Compounds and methods to inhibit or augment an inflammatory response
US6794133B1 (en) * 1997-12-11 2004-09-21 The General Hospital Corporation Broad range PCR amplification techniques
JP3115270B2 (ja) * 1997-12-19 2000-12-04 コナミ株式会社 ゲームシステムおよびゲーム用プログラムが記録されたコンピュータ読み取り可能な記録媒体
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6743605B1 (en) * 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
EP1873260B1 (de) * 1998-11-09 2009-03-18 Eiken Kagaku Kabushiki Kaisha Prozess zur Synthetisierung von Nukleinsäure
JP4726381B2 (ja) * 2000-04-07 2011-07-20 栄研化学株式会社 ２本鎖核酸を鋳型とする核酸の増幅方法
EP1564301A4 (de) * 2002-10-29 2007-07-11 Riken Verfahren für nukleinsäureamplifikation

Also Published As

Publication number Publication date
DE69940623D1 (de) 2009-04-30
ATE521718T1 (de) 2011-09-15
US20040132144A1 (en) 2004-07-08
EP1020534B2 (de) 2011-01-05
HK1029378A1 (en) 2001-03-30
JP3313358B2 (ja) 2002-08-12
DE69937223D1 (de) 2007-11-15
ES2369818T3 (es) 2011-12-07
EP1873260B1 (de) 2009-03-18
US7494790B2 (en) 2009-02-24
JP4139424B2 (ja) 2008-08-27
US20090098566A1 (en) 2009-04-16
HK1110902A1 (en) 2008-07-25
EP2045337B1 (de) 2011-08-24
EP1873260A1 (de) 2008-01-02
EP1020534B1 (de) 2007-10-03
JP2007236392A (ja) 2007-09-20
EP2287338B1 (de) 2012-09-05
EP1020534A4 (de) 2004-12-08
MY157626A (en) 2016-06-30
US9909168B2 (en) 2018-03-06
HK1154635A1 (en) 2012-04-27
EP2045337A1 (de) 2009-04-08
US6974670B2 (en) 2005-12-13
MY117621A (en) 2004-07-31
EP2287338A1 (de) 2011-02-23
DE69937223T2 (de) 2008-01-24
ATE426045T1 (de) 2009-04-15
DE1020534T1 (de) 2001-03-01
US6410278B1 (en) 2002-06-25
ES2320814T3 (es) 2009-05-28
US20170107568A1 (en) 2017-04-20
DE69937223T3 (de) 2011-05-05
WO2000028082A1 (fr) 2000-05-18
ES2393056T3 (es) 2012-12-18
MY137889A (en) 2009-03-31
ES2294862T5 (es) 2011-04-12
ES2294862T3 (es) 2008-04-01
EP1020534A1 (de) 2000-07-19
US20020168676A1 (en) 2002-11-14

Similar Documents

Publication Publication Date Title
ATE374833T1 (de) Verfahren zur synthese von nukleinsäuren
ATE118549T1 (de) Verfahren zur synthese von ribonukleinsäure (rns).
CA2355816A1 (en) A system and methods for nucleic acid sequencing of single molecules by polymerase synthesis
AU1057801A (en) Method of detecting variation or polymorphism
ATE282716T1 (de) Verfahren zur amplifikation von nukleinsäuresequenzen
EP1072678A4 (de) Verfahren zum synthetisieren von dna
ATE257861T1 (de) Methoden und zusammensetzungen zur effizienten nukleinsaeuresequenzierung
ATE116327T1 (de) Modifiziertes phosphoramidit-verfahren zur herstellung von modifizierten nukleinsäuren.
ATE301723T1 (de) Verfahren zur herstellung von nukleosid- verbindung
DE60109739D1 (de) Verfahren zur herstellung und immobilisierung von nukleinsäure auf einem silan-modifizierten festträger
EP1061130A4 (de) Transkriptions-promoteren für rna-polymerase und verfahren zur bestimmung einer basensequenz.
DK0857220T3 (da) Sekvensmodifikation af oligonucleotidprimere til manipulering af ikke-templateret nucleotidaddition
WO2002092615A3 (en) Compositions and methods for array-based genomic nucleic acid analysis of biological molecules
DE59809481D1 (de) Verfahren zur Herstellung von Aminocyanacetamid
DE19882538T1 (de) Verfahren zur Isomerisierung von Tilidin Derivaten davon
WO2000008211A3 (en) Methods and compositions for modulating 'marginally indiscriminant' hybridizations

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties