KR100248111B1 - N-말단 폴리에틸렌 글리콜화된 g-csf 또는 그의 유사체 조성물 및 그 제조방법 - Google Patents
N-말단 폴리에틸렌 글리콜화된 g-csf 또는 그의 유사체 조성물 및 그 제조방법 Download PDFInfo
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- KR100248111B1 KR100248111B1 KR1019960703099A KR19960703099A KR100248111B1 KR 100248111 B1 KR100248111 B1 KR 100248111B1 KR 1019960703099 A KR1019960703099 A KR 1019960703099A KR 19960703099 A KR19960703099 A KR 19960703099A KR 100248111 B1 KR100248111 B1 KR 100248111B1
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/321,510 US5824784A (en) | 1994-10-12 | 1994-10-12 | N-terminally chemically modified protein compositions and methods |
| US8/321510 | 1994-10-12 | ||
| PCT/US1995/001729 WO1996011953A1 (en) | 1994-10-12 | 1995-02-08 | N-terminally chemically modified protein compositions and methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR100248111B1 true KR100248111B1 (ko) | 2000-03-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019960703099A Expired - Lifetime KR100248111B1 (ko) | 1994-10-12 | 1995-02-08 | N-말단 폴리에틸렌 글리콜화된 g-csf 또는 그의 유사체 조성물 및 그 제조방법 |
| KR1019997009836A Expired - Lifetime KR100261030B1 (en) | 1994-10-12 | 1999-10-23 | N-terminally chemically modified protein compositions and methods |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019997009836A Expired - Lifetime KR100261030B1 (en) | 1994-10-12 | 1999-10-23 | N-terminally chemically modified protein compositions and methods |
Country Status (19)
| Country | Link |
|---|---|
| US (7) | US5824784A (https=) |
| EP (5) | EP2392594A1 (https=) |
| JP (8) | JP3177251B2 (https=) |
| KR (2) | KR100248111B1 (https=) |
| CN (4) | CN1071760C (https=) |
| AT (2) | ATE179991T1 (https=) |
| CA (3) | CA2472085A1 (https=) |
| DE (3) | DE69533556T2 (https=) |
| DK (1) | DK0733067T3 (https=) |
| ES (2) | ES2131811T3 (https=) |
| GR (1) | GR3030526T3 (https=) |
| IL (3) | IL134754A (https=) |
| LU (1) | LU91006I2 (https=) |
| MX (1) | MX9602259A (https=) |
| NL (1) | NL300106I2 (https=) |
| NZ (1) | NZ281469A (https=) |
| PT (1) | PT822199E (https=) |
| WO (1) | WO1996011953A1 (https=) |
| ZA (1) | ZA951008B (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329191B2 (en) | 2006-11-17 | 2012-12-11 | Dong-A-Pharm. Co., Ltd. | Three-branched polyethylene glycol-G-CSF conjugate |
| WO2019088608A1 (ko) | 2017-10-30 | 2019-05-09 | 한국코러스 주식회사 | 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법 |
Families Citing this family (565)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| WO1990006952A1 (fr) * | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5951974A (en) * | 1993-11-10 | 1999-09-14 | Enzon, Inc. | Interferon polymer conjugates |
| DE69521880T2 (de) * | 1994-02-08 | 2002-01-03 | Amgen Inc., Thousand Oaks | Orales verabreichungssystem von chemischmodifizierten proteinen g-csf |
| US6429290B1 (en) | 1994-08-17 | 2002-08-06 | The Rockefeller University | OB polypeptides, modified forms and derivatives |
| US6001968A (en) | 1994-08-17 | 1999-12-14 | The Rockefeller University | OB polypeptides, modified forms and compositions |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| CA2204726A1 (en) * | 1994-11-09 | 1996-12-27 | Robin E. Offord | Functionalized polymers for site-specific attachment |
| US6008202A (en) * | 1995-01-23 | 1999-12-28 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5795587A (en) | 1995-01-23 | 1998-08-18 | University Of Pittsburgh | Stable lipid-comprising drug delivery complexes and methods for their production |
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| DE69632062T2 (de) | 1995-11-02 | 2004-11-18 | Schering Corp. | Kontinuierliche, niedrigdosierte zytokine-infusionstherapie |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| ES2312179T3 (es) | 1996-12-06 | 2009-02-16 | Amgen Inc. | Terapia combinada que utiliza un inhibidor del il-1 para el tratamiento de enfermedades mediadas por el il-1. |
| WO1998032466A1 (en) * | 1997-01-29 | 1998-07-30 | Polymasc Pharmaceuticals Plc | Pegylation process |
| JP4011124B2 (ja) | 1997-06-06 | 2007-11-21 | 協和醗酵工業株式会社 | 化学修飾ポリペプチド |
| US20080076706A1 (en) | 1997-07-14 | 2008-03-27 | Bolder Biotechnology, Inc. | Derivatives of Growth Hormone and Related Proteins, and Methods of Use Thereof |
| US6753165B1 (en) * | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
| ES2297889T3 (es) * | 1997-07-14 | 2008-05-01 | Bolder Biotechnology, Inc. | Derivados de hormona de crecimiento y proteinas relacionadas. |
| US6017876A (en) * | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| US5981709A (en) * | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
| US5985263A (en) * | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
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1994
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1995
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- 1995-02-08 CA CA002472085A patent/CA2472085A1/en not_active Abandoned
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- 1995-02-08 PT PT97117514T patent/PT822199E/pt unknown
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- 1995-02-08 AT AT97117514T patent/ATE277078T1/de active
- 1995-02-08 CN CNA2005101137680A patent/CN1896103A/zh active Pending
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- 1995-02-08 EP EP97117514A patent/EP0822199B1/en not_active Revoked
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1996
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1997
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- 1999-10-23 KR KR1019997009836A patent/KR100261030B1/ko not_active Expired - Lifetime
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2001
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2002
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- 2002-11-04 NL NL300106C patent/NL300106I2/nl unknown
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2003
- 2003-01-29 LU LU91006C patent/LU91006I2/fr unknown
- 2003-04-10 JP JP2003106520A patent/JP2003327600A/ja active Pending
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2005
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2006
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2009
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2010
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2012
- 2012-08-02 US US13/565,447 patent/US20120296072A1/en not_active Abandoned
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8329191B2 (en) | 2006-11-17 | 2012-12-11 | Dong-A-Pharm. Co., Ltd. | Three-branched polyethylene glycol-G-CSF conjugate |
| WO2019088608A1 (ko) | 2017-10-30 | 2019-05-09 | 한국코러스 주식회사 | 콜로니자극인자와 폴리올이 접합된 접합물을 고수율로 제조하는 방법 |
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