ES8800982A1 - Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina. - Google Patents

Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina.

Info

Publication number
ES8800982A1
ES8800982A1 ES556436A ES556436A ES8800982A1 ES 8800982 A1 ES8800982 A1 ES 8800982A1 ES 556436 A ES556436 A ES 556436A ES 556436 A ES556436 A ES 556436A ES 8800982 A1 ES8800982 A1 ES 8800982A1
Authority
ES
Spain
Prior art keywords
equal
different
same
present
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES556436A
Other languages
English (en)
Other versions
ES556436A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of ES556436A0 publication Critical patent/ES556436A0/es
Publication of ES8800982A1 publication Critical patent/ES8800982A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA ENZIMA SUPEROXIDO-DISMUTASA, DE FORMULA (I). COMPRENDE LA REACCION DE SUPEROXIDO-DISMUTASA CON UN COMPUESTO DE FORMULA (II), PARA OBTENER EL COMPUESTO DE FORMULA (I), EN LA QUE SOD ES LA SUPEROXIDO-DISMUTASA, QUE CONTIENE MANGANESO, R1 Y R2 REPRESENTAN GRUPOS PROTECTORES DE HIDROXI, M Y N VALEN 7-700 Y X VALE 1 A 30. LA REACCION SE EFECTUA EN BENCENO O TOLUENO, A UNA TEMPERATURA COMPRENDIDA ENTRE 50JC Y 80JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIINFLAMATORIOS.
ES556436A 1985-07-05 1986-06-23 Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina. Expired ES8800982A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14892285 1985-07-05

Publications (2)

Publication Number Publication Date
ES556436A0 ES556436A0 (es) 1987-12-01
ES8800982A1 true ES8800982A1 (es) 1987-12-01

Family

ID=15463658

Family Applications (1)

Application Number Title Priority Date Filing Date
ES556436A Expired ES8800982A1 (es) 1985-07-05 1986-06-23 Un metodo para producir la enzima superoxido-dismutasa modificada con derivados de polietilenglicol y triazina.

Country Status (5)

Country Link
EP (1) EP0210761A1 (es)
JP (1) JPS62115280A (es)
ES (1) ES8800982A1 (es)
GR (1) GR861717B (es)
PT (1) PT82917B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5214132A (en) * 1986-12-23 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Polypeptide derivatives of human granulocyte colony stimulating factor
AU607764B2 (en) * 1987-05-21 1991-03-14 Masayasu Inoue Acylated derivative of superoxide dismutase and composition containing same
JPS6467186A (en) * 1987-09-04 1989-03-13 Kanebo Ltd Modified superoxide dismutase
JPH0796558B2 (ja) * 1988-03-31 1995-10-18 協和醗酵工業株式会社 修飾ポリペプチド
JP2989002B2 (ja) * 1988-12-22 1999-12-13 キリン―アムジエン・インコーポレーテツド 化学修飾顆粒球コロニー刺激因子
US6166183A (en) * 1992-11-30 2000-12-26 Kirin-Amgen, Inc. Chemically-modified G-CSF
ATE136315T1 (de) * 1989-05-27 1996-04-15 Sumitomo Pharma Verfahren für die herstellung von polyethylenglykolderivate und modifizierte proteine.
US5342940A (en) * 1989-05-27 1994-08-30 Sumitomo Pharmaceuticals Company, Limited Polyethylene glycol derivatives, process for preparing the same
JPH04218000A (ja) * 1990-02-13 1992-08-07 Kirin Amgen Inc 修飾ポリペプチド
DE4013142C2 (de) * 1990-04-25 1998-08-27 Solvay Enzymes Gmbh & Co Kg Verfahren zur gezielten Veränderung der Eigenschaften von Enzymen durch chemische Modifizierung und chemisch modifizierte Enzyme
JP3051145B2 (ja) * 1990-08-28 2000-06-12 住友製薬株式会社 新規なポリエチレングリコール誘導体修飾ペプチド
JP2620728B2 (ja) * 1990-10-23 1997-06-18 富士写真フイルム株式会社 ペプチド含有ポリエチレングリコール誘導体とその用途
US5414135A (en) * 1991-12-30 1995-05-09 Sterling Winthrop Inc. Vinyl sulfone coupling of polyoxyalkylenes to proteins
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
US20030053982A1 (en) 1994-09-26 2003-03-20 Kinstler Olaf B. N-terminally chemically modified protein compositions and methods
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JP4142569B2 (ja) * 2001-06-22 2008-09-03 協和醗酵工業株式会社 軟膏剤
ZA200610134B (en) * 2004-06-18 2008-06-25 Genentech Inc Use of Apo2L receptor agonists and NK cells or NK cell activators
AU2005326226B2 (en) 2005-01-31 2010-11-11 Eci, Inc. Immunopotentiating agent
CN117551625B (zh) * 2024-01-12 2024-03-08 山东爱维德生物科技有限公司 一种用于木立芦荟sod胶的聚乙二醇二胺-海藻酸改性sod酶及其应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5729285A (en) * 1980-07-30 1982-02-17 Takeda Chem Ind Ltd Superoxide dismutase and its preparation
DE3273448D1 (en) * 1981-07-22 1986-10-30 Takeda Chemical Industries Ltd Immobilized superoxide dismutase, its production and pharmaceutical composition

Also Published As

Publication number Publication date
JPS62115280A (ja) 1987-05-26
ES556436A0 (es) 1987-12-01
GR861717B (en) 1986-11-04
PT82917A (en) 1986-08-01
PT82917B (pt) 1989-01-30
EP0210761A1 (en) 1987-02-04

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