ES8505405A1 - Un procedimiento para producir un activador de plasminogeno purificado. - Google Patents
Un procedimiento para producir un activador de plasminogeno purificado.Info
- Publication number
- ES8505405A1 ES8505405A1 ES524652A ES524652A ES8505405A1 ES 8505405 A1 ES8505405 A1 ES 8505405A1 ES 524652 A ES524652 A ES 524652A ES 524652 A ES524652 A ES 524652A ES 8505405 A1 ES8505405 A1 ES 8505405A1
- Authority
- ES
- Spain
- Prior art keywords
- plasminogen activator
- production
- composition containing
- derived cells
- thrombolytic composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
PROCEDIMIENTO PARA LA PRODUCCION DE UN ACTIVADOR DE PLASMINOGENO PURIFICADO.CONSISTE EN SEPARAR UNA FRACCION, QUE CONTIENE EL ACTIVADOR DE PLASMINOGENO, DE UN LIQUIDO DE TRATAMIENTO CULTIVADO DE TEJIDO DE CELULAS DERIVADAS DE TEJIDO NORMAL HUMANO, EN PARTICULAR DE RIN/ON DE EMBRION, INTESTINOS, PULMONES, CORAZON, URETER, PIEL O PREPUCIO, Y EN PURIFICAR LA FRACCION SEPARADA.DE APLICACION EN MEDICINA COMO INGREDIENTE ACTIVO EN UNA COMPOSICION TROMBOLITICA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP57133633A JPS5951220A (ja) | 1982-08-02 | 1982-08-02 | 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES524652A0 ES524652A0 (es) | 1985-05-16 |
ES8505405A1 true ES8505405A1 (es) | 1985-05-16 |
Family
ID=15109380
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES524652A Expired ES8505405A1 (es) | 1982-08-02 | 1983-08-01 | Un procedimiento para producir un activador de plasminogeno purificado. |
Country Status (6)
Country | Link |
---|---|
US (1) | US4505893A (es) |
EP (1) | EP0100982B2 (es) |
JP (1) | JPS5951220A (es) |
CA (1) | CA1209940A (es) |
DE (1) | DE3374417D1 (es) |
ES (1) | ES8505405A1 (es) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA831399B (en) * | 1982-03-05 | 1984-02-29 | Health Lab Service Board | New fibrinolytic enzymes and methods for their production and pharmaceutical compositions containing them |
GT198302091A (es) * | 1982-05-05 | 1984-10-25 | Activador de plasminogeno de tejido humano a),b),c). | |
FI831484L (fi) | 1982-05-05 | 1983-11-06 | Genentech Inc | Plasminogen aktivator foer maenskovaevnad |
US4766075A (en) * | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US6001355A (en) * | 1982-12-14 | 1999-12-14 | Dowdle; Eugene Bernard Davey | Pro-tPA for the treatment of thrombosis, embolism and related conditions |
JPS59196824A (ja) * | 1983-04-21 | 1984-11-08 | Kowa Co | 吸着防止剤 |
EP0151996B1 (en) * | 1984-01-30 | 1991-04-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for the preparation of a double-chain plasminogen activator |
JPS60158115A (ja) * | 1984-01-30 | 1985-08-19 | Meiji Milk Prod Co Ltd | プラズミノーゲンアクチベーターの製造法 |
EP0156169B1 (en) * | 1984-02-29 | 1991-12-18 | Asahi Kasei Kogyo Kabushiki Kaisha | An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method |
US4757005A (en) * | 1984-04-19 | 1988-07-12 | Miles Inc. | Method and cell line for obtaining plasminogen activators |
DE3479814D1 (en) * | 1984-06-05 | 1989-10-26 | Asahi Chemical Ind | Process for the preparation of a plasminogen activator |
US4550080A (en) * | 1984-06-05 | 1985-10-29 | Asahi Kasei Kogyo Kabushiki Kaisha | Process for the preparation of a plasminogen activator |
US4753879A (en) * | 1984-08-27 | 1988-06-28 | Biogen N.V. | Modified tissue plasminogen activators |
JPS61176600A (ja) * | 1985-01-31 | 1986-08-08 | Asahi Chem Ind Co Ltd | 人正常細胞由来の新規な組織型プラスミノ−ゲンアクチベ−タ−に対するモノクロナル抗体 |
DE3663030D1 (en) * | 1985-02-07 | 1989-06-01 | Kowa Co | Monoclonal antibodies to tissue plasminogen activator derived from human normal cells |
JPS61221128A (ja) * | 1985-03-26 | 1986-10-01 | Snow Brand Milk Prod Co Ltd | プラスミノ−ゲン活性化因子に対するモノクロ−ナル抗体とその調製方法及び該モノクロ−ナル抗体の使用方法 |
DE3512910A1 (de) * | 1985-04-11 | 1986-10-16 | Behringwerke Ag, 3550 Marburg | Verfahren zur reinigung von plasminogenaktivatoren |
NO171344C (no) * | 1985-05-28 | 1993-03-03 | Wellcome Found | Fremgangsmaate for fremstilling av farmasoeytiske preparater inneholdende vevsplasminogenaktivator |
US4929444A (en) * | 1985-05-28 | 1990-05-29 | Burroughs Wellcome Co. | Low pH pharmaceutical formulation containing t-PA |
US4889808A (en) * | 1985-10-01 | 1989-12-26 | American Home Products | Method of enchancing t-PA and SCU-PA production |
JPH0672105B2 (ja) * | 1985-10-02 | 1994-09-14 | 持田製薬株式会社 | 血栓溶解剤及びその製法 |
NL8503097A (nl) * | 1985-11-11 | 1987-06-01 | Leuven Res & Dev Vzw | Geneesmiddel met thrombolytische werking. |
US5034225A (en) * | 1985-12-17 | 1991-07-23 | Genentech Inc. | Stabilized human tissue plasminogen activator compositions |
US4851517A (en) * | 1986-02-26 | 1989-07-25 | Monsanto Company | Tissue plasminogen activator oligosaccharide from normal human colon cells |
US4927630A (en) * | 1986-02-26 | 1990-05-22 | Monsanto Company | Tissue plasminogen activator from normal human colon cells |
US5132214A (en) * | 1986-04-09 | 1992-07-21 | Monsanto Company | Large scale production of plasminogen activator from normal human colon cells |
US4751084A (en) * | 1986-02-26 | 1988-06-14 | Monsanto Company | Tissue plasminogen activator from normal human colon cells |
US4976959A (en) * | 1986-05-12 | 1990-12-11 | Burroughs Wellcome Co. | T-PA and SOD in limiting tissue damage |
PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
JPH0789951B2 (ja) * | 1986-06-18 | 1995-10-04 | 財団法人阪大微生物病研究会 | 遺伝子発現産物の精製法 |
US4857320A (en) * | 1987-02-19 | 1989-08-15 | Monsanto Company | Method of enhancing the solubility of tissue plasminogen activator |
US4929560A (en) * | 1988-02-03 | 1990-05-29 | Damon Biotech, Inc. | Recovery of tissue plasminogen activator |
US5997856A (en) * | 1988-10-05 | 1999-12-07 | Chiron Corporation | Method and compositions for solubilization and stabilization of polypeptides, especially proteins |
US4980165A (en) * | 1989-01-27 | 1990-12-25 | Genetics Institute, Inc. | Pharmaceutical formulations of plasminogen activator proteins |
DE3942143A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | T-pa pro stabilisierung |
DE3942141A1 (de) * | 1989-12-20 | 1991-06-27 | Boehringer Mannheim Gmbh | K2p pro-stabilisierung |
US5889293A (en) * | 1997-04-04 | 1999-03-30 | International Business Machines Corporation | Electrical contact to buried SOI structures |
GB9907553D0 (en) * | 1999-04-01 | 1999-05-26 | Cantab Pharma Res | Purification of biological preparations |
US20090130714A1 (en) * | 2007-09-24 | 2009-05-21 | Reliance Life Sciences Pvt.Ltd. | Process for purifying recombinanat tissue plasminogen activator (TPA) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3015699C2 (de) * | 1979-04-26 | 1982-07-15 | Asahi Kasei Kogyo K.K., Osaka | Herstellung eines Plasminogen-Aktivators |
EP0040238B1 (en) * | 1979-11-13 | 1984-07-11 | HUSAIN, Syed Shaukat | Plasminogen activators useful as therapeutic and diagnostic agents and their isolation |
NL8003402A (nl) * | 1980-06-11 | 1982-01-04 | Leuven Res & Dev Vzw | Nieuwe plasminogeen-activator en farmaceutisch preparaat met trombolytische werking. |
IL63317A (en) * | 1981-07-15 | 1985-05-31 | Yeda Res & Dev | Production of plasminogen activator |
-
1982
- 1982-08-02 JP JP57133633A patent/JPS5951220A/ja active Granted
-
1983
- 1983-07-30 DE DE8383107531T patent/DE3374417D1/de not_active Expired
- 1983-07-30 EP EP83107531A patent/EP0100982B2/en not_active Expired - Lifetime
- 1983-08-01 ES ES524652A patent/ES8505405A1/es not_active Expired
- 1983-08-01 US US06/519,347 patent/US4505893A/en not_active Expired - Lifetime
- 1983-08-02 CA CA000433716A patent/CA1209940A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
EP0100982A3 (en) | 1984-07-25 |
EP0100982A2 (en) | 1984-02-22 |
EP0100982B1 (en) | 1987-11-11 |
JPH0357749B2 (es) | 1991-09-03 |
EP0100982B2 (en) | 1991-05-29 |
JPS5951220A (ja) | 1984-03-24 |
CA1209940A (en) | 1986-08-19 |
ES524652A0 (es) | 1985-05-16 |
DE3374417D1 (en) | 1987-12-17 |
US4505893A (en) | 1985-03-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000201 |