JPS6467186A - Modified superoxide dismutase - Google Patents

Modified superoxide dismutase

Info

Publication number
JPS6467186A
JPS6467186A JP62222773A JP22277387A JPS6467186A JP S6467186 A JPS6467186 A JP S6467186A JP 62222773 A JP62222773 A JP 62222773A JP 22277387 A JP22277387 A JP 22277387A JP S6467186 A JPS6467186 A JP S6467186A
Authority
JP
Japan
Prior art keywords
superoxide dismutase
polysaccharides
active
carry out
cellulose
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62222773A
Other languages
Japanese (ja)
Inventor
Hiroshi Nakayama
Yasumitsu Fujino
Hiroshi Jinno
Kosuke Tomita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Unitika Ltd
Original Assignee
Kanebo Ltd
Unitika Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd, Unitika Ltd filed Critical Kanebo Ltd
Priority to JP62222773A priority Critical patent/JPS6467186A/en
Publication of JPS6467186A publication Critical patent/JPS6467186A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PURPOSE:To obtain a modified superoxide dismutase having high activity and excellent thermal stability, by linking a manganese type superoxide dismutase produced by a bacterium belonging to the genus Bacillus to polysaccharides. CONSTITUTION:Polysaccharides, such as pectin, carrageenan, alginic acid, agar, mannan, xanthan gum, dextran, pullulan, inulin, gum arabic, chitosan, carboxymethyl cellulose, methyl cellulose and aminoethyl cellulose, having >=2,000 average molecular weight are activated with a suitable reagent or binder and then active parts of the above-mentioned polysaccharides are linked to amino groups of superoxide dismutase in a neutral or weak alkaline solution at ambient temperature to carry out modification of the superoxide dismutase. The excessive active groups in the active polysaccharides are subsequently reacted with a compound having amino group to carry out post-treatment and the residual unreacted reagents, etc., are removed by ultrafiltration, etc., to afford the aimed modified superoxide dismutase.
JP62222773A 1987-09-04 1987-09-04 Modified superoxide dismutase Pending JPS6467186A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62222773A JPS6467186A (en) 1987-09-04 1987-09-04 Modified superoxide dismutase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62222773A JPS6467186A (en) 1987-09-04 1987-09-04 Modified superoxide dismutase

Publications (1)

Publication Number Publication Date
JPS6467186A true JPS6467186A (en) 1989-03-13

Family

ID=16787663

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62222773A Pending JPS6467186A (en) 1987-09-04 1987-09-04 Modified superoxide dismutase

Country Status (1)

Country Link
JP (1) JPS6467186A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02273176A (en) * 1989-04-13 1990-11-07 Seikagaku Kogyo Co Ltd Superoxide dismutase modified with glycosaminoglycan and production thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5816680A (en) * 1981-07-07 1983-01-31 ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Soluble liver uricase, production thereof and measuring of uric acid
JPS62115280A (en) * 1985-07-05 1987-05-26 Takeda Chem Ind Ltd Modifying enzyme, production and use thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5816680A (en) * 1981-07-07 1983-01-31 ベ−リンガ−・マンハイム・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング Soluble liver uricase, production thereof and measuring of uric acid
JPS62115280A (en) * 1985-07-05 1987-05-26 Takeda Chem Ind Ltd Modifying enzyme, production and use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02273176A (en) * 1989-04-13 1990-11-07 Seikagaku Kogyo Co Ltd Superoxide dismutase modified with glycosaminoglycan and production thereof

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