ES8707553A1 - Procedimiento para la obtencion de un peptido. - Google Patents

Procedimiento para la obtencion de un peptido.

Info

Publication number
ES8707553A1
ES8707553A1 ES553691A ES553691A ES8707553A1 ES 8707553 A1 ES8707553 A1 ES 8707553A1 ES 553691 A ES553691 A ES 553691A ES 553691 A ES553691 A ES 553691A ES 8707553 A1 ES8707553 A1 ES 8707553A1
Authority
ES
Spain
Prior art keywords
peptides
activity
formula
human plasma
plasma renin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553691A
Other languages
English (en)
Other versions
ES553691A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES8707553A1 publication Critical patent/ES8707553A1/es
Publication of ES553691A0 publication Critical patent/ES553691A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEIDMIENTO PARA LA OBTENCION DE PEPTIDOS DE FORMULA (I) Y DE SUS SALES. CONSISTE EN EL TRATAMIENTO DE UN DERIVADO FUNCIONAL DE UN COMPUESTO DE FORMULA (I), CON UN AGENTE SOLVOLIZANTE O HIDROGENOLIZANTE A UNA TEMPERATURA COMPRENDIDA ENTRE 0JC Y 50JC, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE TODOS LOS SIMBOLOS PUEDEN SER VARIOS TIPOS DE RADICALES. TAMBIEN SE PUEDE OBTENER POR REDUCCION O AMINACION DEL COMPUESTO ADECUADO. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ENFERMEDADES CARDIACAS, CIRCULATORIAS Y VASCULARES.
ES553691A 1985-04-03 1986-04-03 Procedimiento para la obtencion de un peptido. Expired ES8707553A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853512128 DE3512128A1 (de) 1985-04-03 1985-04-03 Peptide

Publications (2)

Publication Number Publication Date
ES8707553A1 true ES8707553A1 (es) 1987-08-01
ES553691A0 ES553691A0 (es) 1987-08-01

Family

ID=6267170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553691A Expired ES8707553A1 (es) 1985-04-03 1986-04-03 Procedimiento para la obtencion de un peptido.

Country Status (10)

Country Link
US (1) US4755592A (es)
EP (1) EP0198271B1 (es)
JP (1) JPS61229851A (es)
AT (1) ATE90359T1 (es)
AU (1) AU591892B2 (es)
CA (1) CA1276390C (es)
DE (2) DE3512128A1 (es)
ES (1) ES8707553A1 (es)
HU (1) HU201776B (es)
ZA (1) ZA862484B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4729985A (en) * 1985-08-09 1988-03-08 Pfizer Inc. Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
DE3619508A1 (de) * 1986-06-10 1987-12-17 Merck Patent Gmbh Aminosaeurederivate
DE3640535A1 (de) * 1986-11-27 1988-06-01 Merck Patent Gmbh Peptide
US5268374A (en) * 1988-10-04 1993-12-07 Abbott Laboratories Non-peptide renin inhibitors
US5164388A (en) * 1988-10-19 1992-11-17 Abbott Laboratories Heterocyclic peptide renin inhibitors
IL92011A0 (en) * 1988-10-19 1990-07-12 Abbott Lab Heterocyclic peptide renin inhibitors
US5972719A (en) * 1996-11-05 1999-10-26 Pharmacopeia, Inc. Combinatorial hydroxy-amino acid amide libraries
WO2001032162A1 (en) * 1999-11-03 2001-05-10 Howard J. Smith & Associates Pty Ltd Liver selective therapy
BR112013020025A2 (pt) 2011-02-08 2017-03-21 Merck Patent Gmbh derivados de aminoestatina para o tratamento de artrose
US9624264B2 (en) 2012-07-24 2017-04-18 Merck Patent Gmbh Hydroxystatin derivatives for the treatment of arthrosis

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4384994A (en) 1981-10-08 1983-05-24 Merck & Co., Inc. Renin inhibitory peptides
CA1258748A (en) 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
CA1245217A (en) 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
FR2531951A1 (fr) * 1982-08-17 1984-02-24 Sanofi Sa Derives peptidiques inhibiteurs de proteases acides, procede pour leur preparation et medicaments qui en contiennent
US4595677A (en) * 1982-12-03 1986-06-17 Ciba-Geigy Corporation Substituted tetrapeptides
WO1984003044A1 (en) * 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
GB8305985D0 (en) * 1983-03-04 1983-04-07 Szelke M Enzyme inhibition
FI850948L (fi) * 1984-03-12 1985-09-13 Pfizer Renin inhibitorer som innehaoller statin eller dess derivat.
DE3418491A1 (de) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt Diaminosaeurederivate
FR2564844A1 (fr) * 1984-05-25 1985-11-29 Sanofi Sa Nouveaux peptides derives de la statine, procede d'obtention et compositions pharmaceutiques les contenant

Also Published As

Publication number Publication date
ZA862484B (en) 1986-11-26
EP0198271B1 (de) 1993-06-09
DE3512128A1 (de) 1986-10-09
AU5530286A (en) 1986-10-09
ES553691A0 (es) 1987-08-01
ATE90359T1 (de) 1993-06-15
US4755592A (en) 1988-07-05
AU591892B2 (en) 1989-12-21
HU201776B (en) 1990-12-28
HUT42102A (en) 1987-06-29
EP0198271A2 (de) 1986-10-22
CA1276390C (en) 1990-11-13
JPS61229851A (ja) 1986-10-14
EP0198271A3 (en) 1990-02-28
DE3688536D1 (en) 1993-07-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970505