AU7383387A - Amino acid derivatives - Google Patents

Amino acid derivatives

Info

Publication number
AU7383387A
AU7383387A AU73833/87A AU7383387A AU7383387A AU 7383387 A AU7383387 A AU 7383387A AU 73833/87 A AU73833/87 A AU 73833/87A AU 7383387 A AU7383387 A AU 7383387A AU 7383387 A AU7383387 A AU 7383387A
Authority
AU
Australia
Prior art keywords
amino acid
acid derivatives
chr
activity
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU73833/87A
Other versions
AU613869B2 (en
Inventor
Joachim Dr. Gante
Gunter Dr. Holzemann
Alfred Dr. Jonczyk
Klaus Otto Dr. Minck
Peter Dr. Raddatz
Claus J. Dr. Schmitges
Johannes Dr. Sombroek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19863619508 external-priority patent/DE3619508A1/en
Priority claimed from DE19863638425 external-priority patent/DE3638425A1/en
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of AU7383387A publication Critical patent/AU7383387A/en
Application granted granted Critical
Publication of AU613869B2 publication Critical patent/AU613869B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel amino acid derivatives of the formula I X-(NR<1>-HR<2>-CO)k-Z-(CH2)m-CO-NR<3>-CHR<4>-CR<5>-(CHR<6>)n-CO-E-Q-Y where X, Z, E, Q, Y, R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, k, m and n are as defined in patent claim 1, and their salts inhibit the activity of human plasma renin.
AU73833/87A 1986-06-10 1987-06-04 Amino acid derivatives Ceased AU613869B2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19863619508 DE3619508A1 (en) 1986-06-10 1986-06-10 Amino acid derivatives
DE3619508 1986-06-10
DE19863638425 DE3638425A1 (en) 1986-11-11 1986-11-11 Amino-acid derivatives
DE3638425 1986-11-11

Publications (2)

Publication Number Publication Date
AU7383387A true AU7383387A (en) 1987-12-17
AU613869B2 AU613869B2 (en) 1991-08-15

Family

ID=25844524

Family Applications (1)

Application Number Title Priority Date Filing Date
AU73833/87A Ceased AU613869B2 (en) 1986-06-10 1987-06-04 Amino acid derivatives

Country Status (6)

Country Link
EP (1) EP0249096B1 (en)
KR (1) KR880000468A (en)
AT (1) ATE116994T1 (en)
AU (1) AU613869B2 (en)
ES (1) ES2066755T3 (en)
HU (1) HUT46294A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623631B2 (en) * 1988-02-19 1992-05-21 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives
AU626835B2 (en) * 1988-03-18 1992-08-13 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3717631A1 (en) * 1987-05-26 1988-12-15 Merck Patent Gmbh AMINO ACID DERIVATIVES
US5162527A (en) * 1987-10-26 1992-11-10 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
EP0314060A3 (en) * 1987-10-26 1991-06-19 Warner-Lambert Company Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
EP0327877A3 (en) * 1988-02-06 1991-08-14 MERCK PATENT GmbH Peptide-renininhibitors
DE3812328A1 (en) * 1988-04-14 1989-10-26 Merck Patent Gmbh AMINOSAEUREDERIVATE
US5036053A (en) * 1988-05-27 1991-07-30 Warner-Lambert Company Diol-containing renin inhibitors
DE3840289A1 (en) * 1988-11-30 1990-05-31 Merck Patent Gmbh AMINOSAEUREDERIVATE
DE4033062A1 (en) * 1990-10-18 1992-04-23 Merck Patent Gmbh AMINOSAEUREDERIVATE
DE4008403A1 (en) * 1990-03-16 1991-09-19 Merck Patent Gmbh GLYKOLSAEUREDERIVATE
DE4027457A1 (en) * 1990-08-30 1992-03-05 Merck Patent Gmbh AMINO ACID DERIVATIVES

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3418491A1 (en) * 1984-05-18 1985-11-21 Merck Patent Gmbh, 6100 Darmstadt DIAMINO ACID DERIVATIVES
FI88400C (en) * 1984-08-06 1993-05-10 Upjohn Co FRAMEWORK FOR THE FRAME STATION INHIBITION OF PEPTIDER

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623631B2 (en) * 1988-02-19 1992-05-21 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives
AU626835B2 (en) * 1988-03-18 1992-08-13 Merck Patent Gesellschaft Mit Beschrankter Haftung Amino acid derivatives

Also Published As

Publication number Publication date
EP0249096B1 (en) 1995-01-11
EP0249096A2 (en) 1987-12-16
HUT46294A (en) 1988-10-28
EP0249096A3 (en) 1990-04-18
ES2066755T3 (en) 1995-03-16
ATE116994T1 (en) 1995-01-15
AU613869B2 (en) 1991-08-15
KR880000468A (en) 1988-03-26

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