DE60323936D1 - Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung - Google Patents
Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendungInfo
- Publication number
- DE60323936D1 DE60323936D1 DE60323936T DE60323936T DE60323936D1 DE 60323936 D1 DE60323936 D1 DE 60323936D1 DE 60323936 T DE60323936 T DE 60323936T DE 60323936 T DE60323936 T DE 60323936T DE 60323936 D1 DE60323936 D1 DE 60323936D1
- Authority
- DE
- Germany
- Prior art keywords
- chiral
- polyketals
- methods
- biodegradable biocompatible
- polyketal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G16/00—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00
- C08G16/02—Condensation polymers of aldehydes or ketones with monomers not provided for in the groups C08G4/00 - C08G14/00 of aldehydes
- C08G16/04—Chemically modified polycondensates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G4/00—Condensation polymers of aldehydes or ketones with polyalcohols; Addition polymers of heterocyclic oxygen compounds containing in the ring at least once the grouping —O—C—O—
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L59/00—Compositions of polyacetals; Compositions of derivatives of polyacetals
- C08L59/02—Polyacetals containing polyoxymethylene sequences only
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Materials For Medical Uses (AREA)
- Compounds Of Unknown Constitution (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Biological Depolymerization Polymers (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34833302P | 2002-01-14 | 2002-01-14 | |
PCT/US2003/001017 WO2003059988A2 (en) | 2002-01-14 | 2003-01-14 | Biodegradable polyketal polymers and methods for their formation and use |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60323936D1 true DE60323936D1 (de) | 2008-11-20 |
Family
ID=23367539
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60323936T Expired - Lifetime DE60323936D1 (de) | 2002-01-14 | 2003-01-14 | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
Country Status (6)
Country | Link |
---|---|
US (3) | US7838619B2 (de) |
EP (1) | EP1468036B1 (de) |
AT (1) | ATE410459T1 (de) |
AU (1) | AU2003209227A1 (de) |
DE (1) | DE60323936D1 (de) |
WO (1) | WO2003059988A2 (de) |
Families Citing this family (65)
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JP4698843B2 (ja) * | 1999-05-17 | 2011-06-08 | エーザイ インコーポレイテッド | 生体活性剤の改良された細胞取り込み |
US8106098B2 (en) * | 1999-08-09 | 2012-01-31 | The General Hospital Corporation | Protein conjugates with a water-soluble biocompatible, biodegradable polymer |
DE60323936D1 (de) | 2002-01-14 | 2008-11-20 | Gen Hospital Corp | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
EP1585817B1 (de) * | 2002-02-20 | 2009-09-02 | The General Hospital Corporation | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
NZ538405A (en) * | 2002-08-01 | 2007-12-21 | Aesgen Inc | Improved treatment of cancer with glutamine and carbohydrate |
US7790150B2 (en) * | 2003-09-05 | 2010-09-07 | The General Hospital Corporation | Dual phase drug release system |
JP2008540558A (ja) * | 2005-05-10 | 2008-11-20 | エモリー・ユニバーシティ | ミセルおよび粒子を用いた、活性物質の送達のための新規の戦略 |
MY166613A (en) * | 2005-11-22 | 2018-07-17 | Gfbiochemicals Ltd | Glycerol levulinate ketals and their use |
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US7850382B2 (en) * | 2007-01-18 | 2010-12-14 | Sanford, L.P. | Valve made from two materials and writing utensil with retractable tip incorporating same |
US7488130B2 (en) * | 2007-02-01 | 2009-02-10 | Sanford, L.P. | Seal assembly for retractable instrument |
US20090004243A1 (en) | 2007-06-29 | 2009-01-01 | Pacetti Stephen D | Biodegradable triblock copolymers for implantable devices |
WO2009032905A1 (en) | 2007-09-04 | 2009-03-12 | Segetis, Inc. | Ketal compounds from polyols and oxocarboxylates |
MX2010005857A (es) * | 2007-11-28 | 2010-11-22 | Mersana Therapeutics Inc | Conjugados de analogos de fumagillina biodegradables biocompatibles. |
US8226312B2 (en) * | 2008-03-28 | 2012-07-24 | Sanford, L.P. | Valve door having a force directing component and retractable instruments comprising same |
US8653223B2 (en) * | 2008-04-16 | 2014-02-18 | Segetis, Inc. | Transketalized compositions, synthesis, and applications |
WO2010017075A1 (en) * | 2008-08-07 | 2010-02-11 | Sigma-Aldrich Co. | Preparation of low molecular weight polylysine and polyornithine in high yield |
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US8221012B2 (en) * | 2008-11-07 | 2012-07-17 | Sanford, L.P. | Retractable instruments comprising a one-piece valve door actuating assembly |
PA8853201A1 (es) | 2008-12-10 | 2010-07-27 | Mersana Therapeutics Inc | Formulaciones farmaceuticas de conjugados de camtotecina-polimero biocompatibles biodegradables |
US8393814B2 (en) | 2009-01-30 | 2013-03-12 | Sanford, L.P. | Retractable instrument having a two stage protraction/retraction sequence |
KR101808867B1 (ko) | 2009-06-22 | 2018-01-18 | 세게티스, 인코포레이티드. | 케탈 화합물 및 이의 용도 |
WO2011038117A2 (en) | 2009-09-23 | 2011-03-31 | The Regents Of The University Of California | Chemically amplified response strategies for medical sciences |
WO2011041487A1 (en) | 2009-09-30 | 2011-04-07 | Innovotech, Llc | Biocompatible and biodegradable polymers from renewable natural polyphenols |
JP2013528665A (ja) | 2010-03-26 | 2013-07-11 | メルサナ セラピューティックス, インコーポレイテッド | ポリヌクレオチドの送達のための修飾ポリマー、その製造方法、およびその使用方法 |
CA2792018A1 (en) | 2010-05-10 | 2011-11-17 | Segetis, Inc. | Fragrant formulations, methods of manufacture thereof and articles comprising the same |
US9074065B2 (en) | 2010-08-12 | 2015-07-07 | Segetis, Inc. | Latex coating compositions including carboxy ester ketal coalescents, methods of manufacture, and uses thereof |
US8828917B2 (en) | 2010-08-12 | 2014-09-09 | Segetis, Inc. | Carboxy ester ketal removal compositions, methods of manufacture, and uses thereof |
CN103097604A (zh) | 2010-09-13 | 2013-05-08 | 赛格提斯有限公司 | 织物软化剂组合物及其制造方法 |
US8758778B2 (en) | 2010-09-16 | 2014-06-24 | The Regents Of The University Of California | Polymeric nano-carriers with a linear dual response mechanism and uses thereof |
KR20130131323A (ko) | 2010-10-18 | 2013-12-03 | 세게티스, 인코포레이티드. | 카복시 에스터 케탈을 포함하는 수희석성 코팅 조성물, 그리고 그의 제조방법 및 용도 |
US8507718B2 (en) | 2010-11-11 | 2013-08-13 | Segetis, Inc. | Ketocarboxylic acids, methods of manufacture and uses thereof |
US9212176B2 (en) | 2010-11-11 | 2015-12-15 | Segetis, Inc. | Polyketal adducts, methods of manufacture and uses thereof |
BR112013010073A2 (pt) | 2010-11-11 | 2016-07-05 | Segetis Inc | adutos de éster polihidróxi cetálico, métodos de fabricação e seus usos |
US8728453B2 (en) | 2011-02-28 | 2014-05-20 | Innovotech, Llc | Combinatorial polymeric compositions for drug delivery |
EP3228325A1 (de) | 2011-06-10 | 2017-10-11 | Mersana Therapeutics, Inc. | Protein-polymer-wirkstoffkonjugate |
WO2013037708A1 (en) * | 2011-09-16 | 2013-03-21 | Ferring B.V. | A fast dissolving pharmaceutical composition |
CN104768538A (zh) | 2012-08-28 | 2015-07-08 | 加利福尼亚大学董事会 | 具有光触发释放机制的聚合物纳米载体 |
US9458414B2 (en) | 2012-09-21 | 2016-10-04 | Gfbiochemicals Limited | Cleaning, surfactant, and personal care compositions |
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CA2892863C (en) | 2012-12-10 | 2022-03-15 | Mersana Therapeutics, Inc. | Polymeric scaffold based on phf for targeted drug delivery |
US10226535B2 (en) | 2012-12-10 | 2019-03-12 | Mersana Therapeutics, Inc. | Auristatin compounds and conjugates thereof |
KR102505172B1 (ko) | 2013-09-19 | 2023-02-28 | 마이크로벤션, 인코포레이티드 | 중합체 필름 |
CA2923753C (en) | 2013-09-19 | 2021-10-12 | Terumo Corporation | Polymer particles |
JP6427564B2 (ja) | 2013-10-11 | 2018-11-21 | アサナ・バイオサイエンシズ,リミテッド・ライアビリティ・カンパニー | タンパク質−ポリマー−薬物共役体 |
EP3054991B1 (de) | 2013-10-11 | 2019-04-03 | Mersana Therapeutics, Inc. | Protein-polymer-wirkstoffkonjugate |
US9688788B2 (en) | 2013-11-08 | 2017-06-27 | Terumo Corporation | Polymer particles |
CA2931547A1 (en) | 2013-12-09 | 2015-06-18 | Durect Corporation | Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same |
WO2015179572A1 (en) | 2014-05-20 | 2015-11-26 | The Regents Of The University Of California | Layerless bioprinting via dynamic optical projection and uses thereof |
TWI695011B (zh) | 2014-06-18 | 2020-06-01 | 美商梅爾莎納醫療公司 | 抗her2表位之單株抗體及其使用之方法 |
US9919058B2 (en) | 2014-07-15 | 2018-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Polyketal particles including a CpG oligodeoxynucleotide for the treatment of lung cancer |
US11324827B2 (en) | 2014-10-01 | 2022-05-10 | Xiamen Sinopeg Biotech Co., Ltd. | Multifunctionalized polyethylene glycol derivative and preparation method therefor |
CN104877127B (zh) | 2015-06-23 | 2017-11-10 | 厦门赛诺邦格生物科技股份有限公司 | 一种八臂聚乙二醇衍生物、制备方法及其修饰的生物相关物质 |
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EP4302782A3 (de) | 2016-03-15 | 2024-03-27 | Mersana Therapeutics, Inc. | Gegen napi2b gerichtete antikörper-wirkstoff-konjugate und verfahren zur verwendung davon |
US11071714B2 (en) | 2016-04-29 | 2021-07-27 | Children's Medical Center Corporation | Poly(ketals) and related compositions and methods |
JP6548843B1 (ja) * | 2016-06-03 | 2019-07-24 | ノバサイト インコーポレイテッド | ポリマーリンカーおよびそれらの使用法 |
KR102162370B1 (ko) | 2016-09-28 | 2020-10-06 | 테루모 가부시키가이샤 | 중합체 입자 |
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CN111545148B (zh) * | 2020-04-07 | 2022-06-07 | 华东交通大学 | 一种手性催化方法及其催化装置 |
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BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
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DE60323936D1 (de) * | 2002-01-14 | 2008-11-20 | Gen Hospital Corp | Bioabbaubare polyketale, verfahren zu ihrer herstellung sowie ihre verwendung |
EP1585817B1 (de) | 2002-02-20 | 2009-09-02 | The General Hospital Corporation | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
CA2492803C (en) | 2002-07-19 | 2013-11-05 | The General Hospital Corporation | Oxime conjugates and methods for their formation and use |
WO2004009774A2 (en) | 2002-07-19 | 2004-01-29 | Amgen Inc. | Protein conjugates with a water-soluble biocompatible, biogradable polymer |
MX367615B (es) | 2002-09-06 | 2019-08-28 | Cerulean Pharma Inc | Polimeros a base de ciclodextrina para el suministro de agentes terapeuticos. |
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-
2003
- 2003-01-14 DE DE60323936T patent/DE60323936D1/de not_active Expired - Lifetime
- 2003-01-14 EP EP03707375A patent/EP1468036B1/de not_active Expired - Lifetime
- 2003-01-14 AU AU2003209227A patent/AU2003209227A1/en not_active Abandoned
- 2003-01-14 AT AT03707375T patent/ATE410459T1/de not_active IP Right Cessation
- 2003-01-14 US US10/501,565 patent/US7838619B2/en not_active Expired - Fee Related
- 2003-01-14 WO PCT/US2003/001017 patent/WO2003059988A2/en not_active Application Discontinuation
-
2009
- 2009-11-18 US US12/620,855 patent/US7951898B2/en not_active Expired - Fee Related
-
2011
- 2011-04-26 US US13/093,951 patent/US8383758B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7838619B2 (en) | 2010-11-23 |
US20060069230A1 (en) | 2006-03-30 |
EP1468036B1 (de) | 2008-10-08 |
WO2003059988A3 (en) | 2003-12-18 |
ATE410459T1 (de) | 2008-10-15 |
US20100150832A1 (en) | 2010-06-17 |
US8383758B2 (en) | 2013-02-26 |
AU2003209227A1 (en) | 2003-07-30 |
US20110275700A1 (en) | 2011-11-10 |
WO2003059988A2 (en) | 2003-07-24 |
US7951898B2 (en) | 2011-05-31 |
EP1468036A2 (de) | 2004-10-20 |
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